3PIQ

crystal structure of human 2909 fab, a quaternary structure-specific antibody against hiv-1

• Total interactions analyzed: 66
• Total true interactions: 28
• Strongest Interaction:
  • Chains: G-K
  • Int. Res.: 23
  • Norm. En. per Res.: -3.0359
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
H-L	-46.2941	-47.0111	-407.273	-500.5782	173	22	11	17385	4	25	25
H-E	-19.0744	1.351	-106.764	-124.4874	55	12	1	4492	0	12	25
H-F	-8.8154	-5.3631	-33.9232	-48.1016	27	1	0	1729	0	7	3
H-I	0.0	-3.7462	-5.2125	-8.9587	9	3	0	211	0	1	1
L-E	-8.9622	-6.284	-38.4209	-53.6671	27	1	0	1815	0	6	3
L-F	0.0	0.0	-0.1582	-0.1582	6	0	0	67	0	0	1
L-I	0.0	0.0	-29.1566	-29.1566	43	2	0	2075	0	5	3
A-B	-38.7662	-39.927	-368.522	-447.2152	168	10	10	16023	4	23	25
A-G	-15.6717	4.8775	-94.9442	-105.7384	51	3	1	4102	0	13	23
A-I	-7.5928	-4.8323	-33.1152	-45.5402	28	1	0	1661	0	7	3
A-J	0.0	0.0	-21.4273	-21.4273	27	3	0	1181	0	0	0
B-G	-8.2465	-4.8952	-46.9423	-60.084	28	3	0	1918	0	7	3
B-I	0.0	0.0	-0.0385	-0.0385	6	0	0	26	0	0	1
C-D	-49.5953	-47.8066	-406.179	-503.5809	169	17	10	16661	5	22	23
C-F	0.0	0.0	-0.6477	-0.6477	9	0	0	110	0	0	0
D-E	0.0	0.0	-1.1845	-1.1845	11	0	0	153	0	1	1
D-F	0.0	0.0	-10.7965	-10.7965	32	0	0	986	0	5	4
D-G	-11.8807	-9.9213	-73.1052	-94.9072	48	2	0	2982	0	12	8
D-J	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
E-F	-37.6856	-47.7081	-395.861	-481.2546	170	13	12	16969	4	25	23
F-G	0.0	0.0	-10.2569	-10.2569	22	1	1	665	0	4	5
F-I	0.0	1.1113	-6.2523	-5.141	12	0	0	454	0	5	3
G-I	-51.7734	-43.9235	-392.14	-487.8368	173	23	12	16708	4	20	23
G-J	0.0	0.0	-9.4599	-9.4599	22	0	0	620	0	0	0
G-K	-16.7163	0.0	-53.1092	-69.8255	23	5	0	1721	0	1	0
I-J	0.0	0.0	-2.2611	-2.2611	8	0	0	158	0	0	0
I-K	0.0	0.0	-0.1688	-0.1688	2	0	0	18	0	1	0
J-K	-55.0155	-47.5007	-413.003	-515.5192	170	19	10	17035	4	24	24

Interface residues

• H-L: ALA125H, ALA127L, ALA130L, ALA136H, ALA137H, ALA168H, ALA173L, ALA174L, ALA43L, ALA60H, ALA93H, ARG210H, ARG38H, ARG56H, ASN128L, ASN169L, ASN32L, ASP100H, ASP101H, ASP138L, ASP144H, ASP53L, ASP61H, ASP85L, ASP92L, ASP95H, ASP95L, ASP98H, CYS134L, CYS140H, CYS88L, GLN103L, GLN126L, GLN167L, GLN171H, GLN37L, GLN38L, GLN39H, GLN42L, GLN46H, GLN89L, GLU123L, GLU124L, GLU160L, GLU6H, GLY100L, GLY101L, GLY102H, GLY104H, GLY106H, GLY139H, GLY158L, GLY162H, GLY41L, GLY42H, GLY44H, GLY97H, GLY99L, HIS164H, HIS34L, HIS35H, HIS95L, ILE136L, ILE48L, LEU117L, LEU124H, LEU125L, LEU132L, LEU135L, LEU138H, LEU141H, LEU170H, LEU175H, LEU178H, LEU178L, LEU180L, LEU45H, LEU46L, LEU4H, LEU50H, LYS105H, LYS129L, LYS143H, LYS166L, LYS171L, LYS209H, LYS214H, LYS43H, LYS64H, LYS94H, LYS96H, MET100H, PHE100H, PHE118L, PHE122H, PHE139L, PHE166H, PHE89H, PHE91H, PHE98L, PRO119L, PRO120L, PRO123H, PRO126H, PRO164L, PRO167H, PRO44L, PRO55L, SER100H, SER114L, SER120H, SER121L, SER122L, SER137L, SER161H, SER165L, SER168L, SER172H, SER173H, SER175L, SER176L, SER177H, SER179H, SER179L, SER180H, SER49H, SER62H, SER93L, SER95L, SER99H, THR116L, THR131L, THR135H, THR160H, THR161L, THR162L, THR163L, THR165H, THR183H, THR57H, TRP103H, TRP35L, TRP36H, TRP47H, TRP91L, TYR100H, TYR145H, TYR172L, TYR177L, TYR36L, TYR49L, TYR50L, TYR58H, TYR59H, TYR86L, TYR87L, VAL121H, VAL133L, VAL142H, VAL159L, VAL163H, VAL169H, VAL181H, VAL182H, VAL211H, VAL33L, VAL37H, VAL45L, VAL48H, VAL63H, VAL90L, VAL96L, VAL97L
• H-E: ARG210E, ARG210H, ASN197E, ASN197H, ASN199E, ASN199H, ASN204E, ASN204H, ASP208E, ASP208H, CYS196E, CYS196H, GLU212E, GLU212H, GLY118E, GLY118H, HIS200E, HIS200H, ILE195E, ILE195H, LYS117E, LYS117H, LYS201E, LYS201H, LYS206E, LYS206H, LYS209E, LYS209H, PHE122E, PHE122H, PRO119E, PRO119H, PRO123E, PRO123H, PRO202E, PRO202H, SER120E, SER120H, SER203E, SER203H, THR116E, THR116H, THR193E, THR193H, THR205E, THR205H, TYR194E, VAL121E, VAL121H, VAL198E, VAL198H, VAL207E, VAL207H, VAL211E, VAL211H
• H-F: ALA114H, ALA127F, ASN128F, ASP144H, GLN126F, GLU123F, GLU124F, GLY118H, GLY174H, HIS200H, LEU125F, LEU175H, LYS117H, LYS129F, PHE146H, PRO119H, PRO202H, SER112H, SER113H, SER115H, SER120H, SER122F, SER173H, SER203H, THR116H, THR205H, TYR145H
• H-I: ALA157I, ASN26I, ASN27I, ASP61H, GLN171H, GLY174H, LYS156I, SER172H, SER173H
• L-E: ALA114E, ALA127L, ASN128L, ASP144E, GLN126L, GLU123L, GLU124L, GLY118E, GLY174E, HIS200E, LEU125L, LEU175E, LYS117E, LYS129L, PHE146E, PRO119E, SER112E, SER113E, SER115E, SER120E, SER121L, SER122L, SER173E, SER203E, THR116E, THR205E, TYR145E
• L-F: ALA127F, ALA127L, ASN128F, ASN128L, LYS129F, LYS129L
• L-I: ALA150I, ALA157I, ALA157L, ALA29I, ARG189I, ASN26I, ASN26L, ASN27I, ASN27L, ASN30I, ASN30L, ASN69I, ASN94L, ASP151I, ASP92L, GLN184I, GLN184L, GLY158L, GLY68I, HIS188I, HIS95L, ILE28I, LYS129L, LYS149I, LYS156I, LYS156L, LYS31L, PRO154I, SER152I, SER153I, SER179L, SER187I, SER67I, SER93L, SER95L, THR181L, THR70I, TYR191I, TYR2L, VAL155I, VAL159L, VAL3L, VAL97L
• A-B: ALA125A, ALA127B, ALA130B, ALA136A, ALA137A, ALA168A, ALA173B, ALA174B, ALA40A, ALA43B, ALA60A, ALA93A, ARG210A, ARG38A, ARG56A, ASN128B, ASN169B, ASN32B, ASP101A, ASP138B, ASP144A, ASP51B, ASP53B, ASP61A, ASP85B, ASP92B, ASP95A, ASP95B, ASP98A, CYS140A, CYS88B, GLN103B, GLN126B, GLN167B, GLN171A, GLN37B, GLN38B, GLN39A, GLN42B, GLN46A, GLN89B, GLU123B, GLU124B, GLU160B, GLU6A, GLY100B, GLY101B, GLY102A, GLY104A, GLY106A, GLY139A, GLY158B, GLY162A, GLY41B, GLY42A, GLY44A, GLY97A, GLY99B, HIS164A, HIS34B, HIS35A, HIS95B, ILE136B, ILE48B, LEU117B, LEU124A, LEU125B, LEU132B, LEU135B, LEU138A, LEU141A, LEU170A, LEU175A, LEU178A, LEU178B, LEU180B, LEU45A, LEU46B, LEU50A, LYS105A, LYS129B, LYS143A, LYS166B, LYS171B, LYS209A, LYS214A, LYS43A, LYS64A, LYS94A, LYS96A, MET100A, PHE100A, PHE118B, PHE122A, PHE139B, PHE166A, PHE89A, PHE91A, PHE98B, PRO119B, PRO120B, PRO123A, PRO126A, PRO164B, PRO167A, PRO44B, PRO55B, SER120A, SER121B, SER122B, SER137B, SER161A, SER165B, SER168B, SER172A, SER173A, SER175B, SER176B, SER177A, SER179A, SER179B, SER180A, SER49A, SER62A, SER93B, SER95B, SER99A, THR102B, THR116B, THR131B, THR160A, THR161B, THR162B, THR163B, THR165A, THR183A, TRP103A, TRP35B, TRP36A, TRP47A, TRP91B, TYR100A, TYR172B, TYR177B, TYR36B, TYR49B, TYR50B, TYR58A, TYR59A, TYR87B, VAL121A, VAL133B, VAL142A, VAL159B, VAL163A, VAL169A, VAL181A, VAL182A, VAL211A, VAL33B, VAL37A, VAL45B, VAL47B, VAL48A, VAL63A, VAL90B, VAL96B, VAL97B
• A-G: ARG210A, ARG210G, ASN197A, ASN197G, ASN199A, ASN199G, ASN204A, ASN204G, ASP208A, ASP208G, CYS196A, CYS196G, GLU212A, GLU212G, GLY118A, GLY118G, HIS200A, HIS200G, ILE195A, ILE195G, LYS117A, LYS117G, LYS201A, LYS201G, LYS206A, LYS206G, LYS209A, LYS209G, PHE122A, PHE122G, PRO119A, PRO119G, PRO123A, PRO123G, PRO202A, PRO202G, SER120A, SER120G, SER203A, SER203G, THR116A, THR205A, THR205G, VAL121A, VAL121G, VAL198A, VAL198G, VAL207A, VAL207G, VAL211A, VAL211G
• A-I: ALA114A, ALA127I, ASN128I, ASN204A, ASP144A, GLN126I, GLU123I, GLU124I, GLY118A, GLY174A, HIS200A, LEU125I, LEU175A, LYS117A, LYS129I, PHE146A, PRO119A, PRO202A, SER112A, SER113A, SER115A, SER120A, SER122I, SER173A, SER203A, THR116A, THR205A, TYR145A
• A-J: ALA158A, ALA24J, ARG210A, ASN155A, ASN73J, ASN76J, ASP30J, ASP31J, ASP72J, GLN192A, GLN3J, GLY190A, GLY26J, ILE195A, LEU159A, LEU189A, LYS75J, PHE27J, PHE29J, SER187A, SER188A, SER25J, SER28J, SER74J, THR191A, THR193A, VAL2J
• B-G: ALA114G, ALA127B, ASN128B, ASN204G, ASP144G, GLN126B, GLU123B, GLU124B, GLY118G, GLY174G, HIS200G, LEU125B, LEU175G, LYS117G, LYS129B, PHE146G, PRO119G, PRO202G, SER112G, SER113G, SER115G, SER120G, SER122B, SER173G, SER203G, THR116G, THR205G, TYR145G
• B-I: ALA127B, ALA127I, ASN128B, ASN128I, LYS129B, LYS129I
• C-D: ALA125C, ALA127D, ALA130D, ALA136C, ALA137C, ALA168C, ALA173D, ALA174D, ALA40C, ALA43D, ALA60C, ALA93C, ARG210C, ARG38C, ARG56C, ASN169D, ASN32D, ASP100C, ASP101C, ASP138D, ASP144C, ASP53D, ASP61C, ASP85D, ASP92D, ASP95C, ASP95D, ASP98C, CYS134D, CYS140C, CYS88D, GLN103D, GLN126D, GLN167D, GLN171C, GLN37D, GLN38D, GLN39C, GLN42D, GLN46C, GLN89D, GLU123D, GLU124D, GLU160D, GLU6C, GLY100D, GLY101D, GLY102C, GLY104C, GLY106C, GLY139C, GLY158D, GLY162C, GLY41D, GLY42C, GLY44C, GLY97C, GLY99D, HIS164C, HIS34D, HIS35C, HIS95D, ILE136D, ILE48D, LEU117D, LEU124C, LEU125D, LEU132D, LEU135D, LEU138C, LEU141C, LEU170C, LEU175C, LEU178C, LEU178D, LEU180D, LEU45C, LEU46D, LEU50C, LYS105C, LYS129D, LYS143C, LYS166D, LYS171D, LYS209C, LYS43C, LYS64C, LYS94C, LYS96C, MET100C, PHE100C, PHE118D, PHE122C, PHE139D, PHE166C, PHE89C, PHE91C, PHE98D, PRO119D, PRO120D, PRO123C, PRO126C, PRO164D, PRO167C, PRO44D, PRO55D, SER114D, SER120C, SER121D, SER122D, SER137D, SER161C, SER165D, SER168D, SER172C, SER173C, SER175D, SER176D, SER177C, SER179C, SER179D, SER180C, SER49C, SER62C, SER93D, SER95D, SER99C, THR116D, THR131D, THR160C, THR161D, THR162D, THR163D, THR165C, THR183C, THR57C, TRP103C, TRP35D, TRP36C, TRP47C, TRP91D, TYR100C, TYR172D, TYR177D, TYR36D, TYR49D, TYR50D, TYR58C, TYR59C, TYR86D, TYR87D, VAL121C, VAL133D, VAL142C, VAL159D, VAL163C, VAL169C, VAL181C, VAL182C, VAL211C, VAL33D, VAL37C, VAL45D, VAL47D, VAL48C, VAL63C, VAL90D, VAL96D, VAL97D
• C-F: ASN26F, ASN69F, ASP61C, LYS64C, THR57C, THR5F, TYR58C, TYR59C, VAL3F
• D-E: ALA29D, ASN26D, ASN27D, ASN30D, ASN69D, ASN94D, ASP61E, GLU85E, LYS83E, SER62E, SER93D
• D-F: ALA147D, ARG189F, ASN26F, ASN94D, ASP151F, ASP92D, ASP95D, GLN194D, GLN194F, GLU203F, GLY199D, HIS95D, HIS95F, LYS149D, LYS149F, LYS156D, LYS156F, PRO154F, SER152F, SER153F, SER200D, SER93D, SER95D, THR145D, THR196D, THR201D, THR201F, THR5D, THR5F, VAL146D, VAL3F, VAL97F
• D-G: ALA111D, ALA112D, ARG56G, ASN100G, ASN53G, ASN73G, ASP100G, ASP30G, ASP31G, ASP98G, GLN103D, GLN108D, GLU198D, GLY199D, GLY54G, GLY55G, GLY97G, HIS197D, LEU106D, LYS110D, LYS171D, LYS17D, LYS96G, PHE139D, PHE29G, PRO109D, PRO113D, PRO141D, PRO7D, PRO8D, SER12D, SER200D, SER28G, SER32G, SER52G, SER99G, SER9D, THR102D, THR201D, THR22D, THR33G, THR5D, TRP52G, TYR100G, TYR140D, VAL11D, VAL13D, VAL202D
• D-J: ARG77D, THR191J
• E-F: ALA125E, ALA127F, ALA130F, ALA136E, ALA137E, ALA168E, ALA173F, ALA174F, ALA43F, ALA60E, ALA93E, ARG210E, ARG38E, ARG56E, ASN169F, ASN32F, ASP101E, ASP138F, ASP144E, ASP53F, ASP61E, ASP85F, ASP92F, ASP95E, ASP95F, ASP98E, CYS134F, CYS140E, CYS88F, GLN103F, GLN126F, GLN167F, GLN171E, GLN37F, GLN38F, GLN39E, GLN42F, GLN46E, GLN89F, GLU123F, GLU124F, GLU160F, GLU6E, GLY100F, GLY101F, GLY102E, GLY104E, GLY106E, GLY139E, GLY158F, GLY162E, GLY41F, GLY42E, GLY44E, GLY97E, GLY99F, HIS164E, HIS34F, HIS35E, HIS95F, ILE136F, ILE48F, LEU117F, LEU124E, LEU125F, LEU132F, LEU135F, LEU138E, LEU141E, LEU170E, LEU175E, LEU178E, LEU178F, LEU180F, LEU45E, LEU46F, LEU4E, LEU50E, LYS105E, LYS129F, LYS143E, LYS166F, LYS171F, LYS209E, LYS214E, LYS31F, LYS43E, LYS64E, LYS94E, LYS96E, MET100E, PHE100E, PHE118F, PHE122E, PHE139F, PHE166E, PHE89E, PHE91E, PHE98F, PRO119F, PRO120F, PRO123E, PRO126E, PRO164F, PRO167E, PRO44F, PRO55F, SER114F, SER120E, SER121F, SER122F, SER137F, SER161E, SER165F, SER168F, SER172E, SER175F, SER176F, SER177E, SER179E, SER179F, SER180E, SER49E, SER62E, SER93F, SER95F, SER99E, THR116F, THR131F, THR135E, THR160E, THR161F, THR162F, THR163F, THR165E, THR183E, TRP103E, TRP35F, TRP36E, TRP47E, TRP91F, TYR100E, TYR145E, TYR172F, TYR177F, TYR36F, TYR49F, TYR50F, TYR58E, TYR59E, TYR86F, TYR87F, VAL121E, VAL133F, VAL142E, VAL159F, VAL163E, VAL169E, VAL181E, VAL182E, VAL211E, VAL33F, VAL37E, VAL45F, VAL47F, VAL48E, VAL63E, VAL90F, VAL96F, VAL97F
• F-G: ALA157F, ARG189F, ARG56G, ASN100G, ASP100G, GLN184F, GLU183F, GLY100G, GLY158F, GLY55G, HIS188F, LEU100G, LEU180F, LYS156F, LYS186F, SER100G, SER153F, SER187F, THR181F, TYR100G, TYR58G, VAL155F
• F-I: ASN128F, ASN30I, ASN94I, ASP95I, GLU183F, LEU125F, LYS186F, PRO182F, SER187F, SER93I, SER95I, TRP91I
• G-I: ALA125G, ALA127I, ALA130I, ALA136G, ALA137G, ALA168G, ALA173I, ALA174I, ALA40G, ALA43I, ALA60G, ALA93G, ARG210G, ARG38G, ARG56G, ASN128I, ASN169I, ASN30I, ASN32I, ASP100G, ASP101G, ASP138I, ASP144G, ASP53I, ASP61G, ASP85I, ASP92I, ASP95G, ASP95I, ASP98G, CYS134I, CYS140G, CYS88I, GLN103I, GLN126I, GLN167I, GLN171G, GLN37I, GLN38I, GLN39G, GLN42I, GLN46G, GLN89I, GLU123I, GLU124I, GLU160I, GLU6G, GLY100I, GLY101I, GLY102G, GLY104G, GLY106G, GLY139G, GLY158I, GLY162G, GLY41I, GLY42G, GLY44G, GLY97G, GLY99I, HIS164G, HIS34I, HIS35G, HIS95I, ILE136I, ILE48I, LEU117I, LEU124G, LEU125I, LEU132I, LEU135I, LEU138G, LEU141G, LEU170G, LEU175G, LEU178G, LEU178I, LEU180I, LEU45G, LEU46I, LEU50G, LYS105G, LYS129I, LYS143G, LYS166I, LYS171I, LYS209G, LYS31I, LYS43G, LYS64G, LYS94G, LYS96G, MET100G, PHE100G, PHE118I, PHE122G, PHE139I, PHE166G, PHE89G, PHE91G, PHE98I, PRO119I, PRO120I, PRO123G, PRO126G, PRO164I, PRO167G, PRO40I, PRO41G, PRO44I, PRO55I, SER100G, SER114I, SER120G, SER121I, SER122I, SER137I, SER161G, SER165I, SER168I, SER172G, SER175I, SER176I, SER177G, SER179G, SER179I, SER180G, SER49G, SER62G, SER93I, SER95I, SER99G, THR116I, THR131I, THR160G, THR161I, THR162I, THR163I, THR165G, THR183G, THR57G, TRP103G, TRP35I, TRP36G, TRP47G, TRP91I, TYR100G, TYR172I, TYR177I, TYR36I, TYR49I, TYR50I, TYR58G, TYR59G, TYR86I, TYR87I, VAL121G, VAL133I, VAL142G, VAL159I, VAL163G, VAL169G, VAL181G, VAL182G, VAL211G, VAL33I, VAL37G, VAL45I, VAL48G, VAL63G, VAL90I, VAL96I, VAL97I
• G-J: ALA158J, ASN155J, ASN204G, GLN3G, GLN3J, GLY157J, GLY26G, GLY26J, LEU159J, LYS201G, LYS206G, LYS94G, PHE27G, SER153J, SER156J, SER25G, SER28G, THR151J, THR160J, TRP154J, VAL2G, VAL2J
• G-K: ALA158G, ARG54K, ARG61K, ARG77K, ASN155G, ASN197G, ASP60K, GLU79K, GLY157G, GLY162G, GLY57K, ILE58K, LEU159G, PHE62K, PRO55K, PRO59K, SER153G, SER156G, SER161G, SER56K, THR160G, TRP154G, VAL163G
• I-J: GLY162J, GLY57I, ILE58I, LEU159J, PRO185J, SER161J, SER56I, THR160J
• I-K: GLU79K, SER168I
• J-K: ALA125J, ALA127K, ALA130K, ALA136J, ALA137J, ALA168J, ALA173K, ALA174K, ALA43K, ALA60J, ALA93J, ARG210J, ARG38J, ARG56J, ASN128K, ASN169K, ASN32K, ASP101J, ASP138K, ASP144J, ASP61J, ASP85K, ASP92K, ASP95J, ASP95K, ASP98J, CYS134K, CYS140J, CYS88K, CYS92J, GLN103K, GLN126K, GLN167K, GLN171J, GLN37K, GLN38K, GLN39J, GLN42K, GLN46J, GLN89K, GLU123K, GLU124K, GLU160K, GLU6J, GLY100K, GLY101K, GLY102J, GLY104J, GLY106J, GLY139J, GLY158K, GLY162J, GLY41K, GLY42J, GLY44J, GLY97J, GLY99K, HIS164J, HIS34K, HIS35J, HIS95K, ILE136K, ILE48K, LEU117K, LEU124J, LEU125K, LEU132K, LEU135K, LEU138J, LEU141J, LEU170J, LEU178J, LEU178K, LEU180K, LEU45J, LEU46K, LEU4J, LEU50J, LYS105J, LYS129K, LYS143J, LYS166K, LYS171K, LYS209J, LYS214J, LYS43J, LYS64J, LYS94J, LYS96J, MET100J, PHE100J, PHE118K, PHE122J, PHE139K, PHE166J, PHE89J, PHE91J, PHE98K, PRO119K, PRO120K, PRO123J, PRO126J, PRO164K, PRO167J, PRO40K, PRO44K, PRO55K, SER100J, SER114K, SER120J, SER121K, SER122K, SER137K, SER165K, SER168K, SER172J, SER173J, SER175K, SER176K, SER177J, SER179J, SER179K, SER180J, SER49J, SER62J, SER93K, SER95K, SER99J, THR116K, THR131K, THR161K, THR162K, THR163K, THR165J, THR183J, THR57J, TRP103J, TRP35K, TRP36J, TRP47J, TRP91K, TYR100J, TYR145J, TYR172K, TYR177K, TYR36K, TYR49K, TYR50K, TYR58J, TYR59J, TYR86K, TYR87K, VAL121J, VAL133K, VAL142J, VAL159K, VAL163J, VAL169J, VAL181J, VAL182J, VAL211J, VAL33K, VAL37J, VAL45K, VAL47K, VAL48J, VAL63J, VAL90K, VAL96K, VAL97K