3PHF

crystal structure of the epstein-barr virus gh and gl complex

• Total interactions analyzed: 496
• Total true interactions: 34
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 177
  • Norm. En. per Res.: -4.4309
• Hub Node: G(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-100.0329	-46.2958	-591.272	-737.6007	170	35	23	25687	4	31	22
B-M	0.0	0.0	-0.0005	-0.0005	2	0	0	1	0	0	0
C-D	-83.8762	-54.3733	-646.015	-784.2645	177	52	27	27389	5	33	23
E-F	-88.0119	-38.6944	-609.745	-736.4514	174	34	23	26693	2	32	21
E-K	-46.3594	-12.8139	-169.319	-228.4923	86	15	0	6853	4	19	15
G-H	-100.7935	-31.4666	-599.888	-732.1482	177	49	25	26522	3	35	24
G-U	-19.4988	-2.7902			10
G-V	-11.5282	0.0			3
H-V	0.0	54.0328			4
I-J	-76.3665	-23.4497	-590.881	-690.6972	174	51	27	26610	3	35	25
I-S	-19.8229	1.4854			5
I-T	0.0	-0.8261			2
J-S	-11.9663	0.0			4
J-T	0.0	56.3575			4
K-L	-109.8367	-28.768	-570.316	-708.9207	173	45	22	25621	3	31	23
M-N	-70.453	-31.2816	-617.402	-719.1367	175	47	28	27053	3	33	23
M-Q	-41.6017	-18.2749	0.0	-59.8766	16	0	0	0	0	0	0
O-P	-56.276	-47.4827	-579.296	-683.0547	175	37	26	26418	2	34	22
O-1	-33.019	-29.2363			13
Q-R	-72.7401	-52.9534			24
S-T	-73.4179	-40.4858			24
U-V	-71.829	-44.847			22
W-X	-82.7727	-36.3808			28
Y-Z	-75.0804	-39.3466			22
Y-1	0.0	1.3185			4
Y-2	0.0	-0.8255			2
Z-1	0.0	-0.8339			2
Z-2	0.0	56.3065			4
1-2	-123.5044	-44.493			29
3-4	-60.9977	-30.5555			21
3-5	-24.6976	1.7988			6
3-6	-6.3285	0.0			2
4-6	0.0	55.0354			4
5-6	-57.4782	-35.6256			25

Interface residues

• A-B: ALA126B, ALA25B, ALA33A, ALA41B, ALA45A, ALA54A, ALA59A, ALA62B, ALA66A, ALA80B, ALA99B, ARG105B, ARG130B, ARG152A, ARG208A, ARG57A, ARG71A, ARG78B, ARG95B, ASN127B, ASN129B, ASN44B, ASN53B, ASN60A, ASN65B, ASN70A, ASN72B, ASN81B, ASN84B, ASP122B, ASP203A, ASP206A, ASP28A, ASP47B, ASP57B, ASP64A, CYS28B, CYS29B, CYS79B, GLN150A, GLN33B, GLN54B, GLU106B, GLU121B, GLU22A, GLU30A, GLU42A, GLU43B, GLU53A, GLU58A, GLU63A, GLY102B, GLY116B, GLY125B, GLY209A, GLY31A, GLY49A, GLY58B, GLY82B, HIS103B, HIS26A, HIS30B, HIS32A, HIS35A, HIS38B, ILE29A, ILE38A, ILE45B, ILE48B, ILE75A, ILE90B, ILE92B, LEU100B, LEU104B, LEU107B, LEU108B, LEU111B, LEU114B, LEU123B, LEU128B, LEU138A, LEU151A, LEU204A, LEU207A, LEU20A, LEU25A, LEU27A, LEU34B, LEU39B, LEU40B, LEU42B, LEU43A, LEU50A, LEU50B, LEU55A, LEU61B, LEU64B, LEU65A, LEU69A, LEU74A, LEU83B, LEU93B, LYS202A, LYS24A, LYS46A, LYS73A, LYS77A, LYS94B, MET44A, MET68A, PHE118B, PHE124B, PHE148A, PHE211A, PHE232A, PHE59B, PHE88B, PHE89B, PRO205A, PRO210A, PRO214A, PRO39A, PRO48A, PRO52A, PRO67B, SER119B, SER212A, SER215A, SER21A, SER34A, SER46B, SER51A, SER52B, SER60B, SER63B, SER66B, SER67A, SER87B, SER91B, SER96B, SER97B, SER98B, THR101B, THR110B, THR113B, THR201A, THR32B, THR37A, THR55B, THR62A, TRP24B, TRP40A, TRP56A, TYR115B, TYR131B, TYR149A, TYR213A, TYR26B, TYR36A, TYR49B, TYR72A, VAL120B, VAL147A, VAL23A, VAL31B, VAL47A, VAL51B, VAL61A, VAL85B, VAL86B
• B-M: ARG130B, ARG406M
• C-D: ALA126D, ALA25D, ALA33C, ALA41D, ALA45C, ALA54C, ALA59C, ALA62D, ALA66C, ALA80D, ALA99D, ARG105D, ARG130D, ARG152C, ARG208C, ARG35D, ARG57C, ARG71C, ARG78D, ARG95D, ASN127D, ASN129D, ASN44D, ASN53D, ASN60C, ASN65D, ASN70C, ASN72D, ASN81D, ASN84D, ASP122D, ASP203C, ASP206C, ASP28C, ASP47D, ASP57D, ASP64C, CYS153C, CYS28D, CYS29D, CYS79D, GLN150C, GLN33D, GLN37D, GLN54D, GLU106D, GLU112D, GLU121D, GLU22C, GLU30C, GLU42C, GLU43D, GLU53C, GLU58C, GLU63C, GLY102D, GLY116D, GLY125D, GLY209C, GLY31C, GLY49C, GLY58D, GLY82D, HIS103D, HIS26C, HIS30D, HIS32C, HIS35C, HIS38D, ILE29C, ILE38C, ILE45D, ILE48D, ILE90D, ILE92D, LEU100D, LEU104D, LEU107D, LEU108D, LEU111D, LEU114D, LEU123D, LEU128D, LEU138C, LEU151C, LEU204C, LEU207C, LEU20C, LEU25C, LEU27C, LEU34D, LEU39D, LEU40D, LEU42D, LEU43C, LEU50C, LEU50D, LEU55C, LEU61D, LEU64D, LEU65C, LEU69C, LEU74C, LEU83D, LEU93D, LYS176C, LYS202C, LYS24C, LYS46C, LYS73C, LYS77C, LYS94D, MET137C, MET44C, MET68C, PHE118D, PHE124D, PHE148C, PHE211C, PHE232C, PHE59D, PHE88D, PHE89D, PRO205C, PRO210C, PRO214C, PRO39C, PRO48C, PRO52C, PRO67D, SER117D, SER119D, SER212C, SER215C, SER21C, SER34C, SER46D, SER51C, SER52D, SER60D, SER63D, SER66D, SER67C, SER87D, SER91D, SER96D, SER97D, SER98D, THR101D, THR109D, THR110D, THR113D, THR201C, THR32D, THR37C, THR55D, THR62C, TRP24D, TRP40C, TRP56C, TYR115D, TYR131D, TYR149C, TYR213C, TYR26D, TYR36C, TYR49D, TYR72C, VAL120D, VAL147C, VAL23C, VAL31D, VAL47C, VAL51D, VAL61C, VAL85D, VAL86D
• E-F: ALA126F, ALA25F, ALA33E, ALA41F, ALA45E, ALA54E, ALA59E, ALA62F, ALA66E, ALA80F, ALA99F, ARG105F, ARG130F, ARG152E, ARG208E, ARG35F, ARG57E, ARG71E, ARG78F, ARG95F, ASN127F, ASN129F, ASN44F, ASN53F, ASN60E, ASN65F, ASN70E, ASN81F, ASN84F, ASP122F, ASP203E, ASP206E, ASP28E, ASP47F, ASP57F, ASP64E, CYS153E, CYS28F, CYS29F, CYS56F, CYS79F, GLN150E, GLN33F, GLN54F, GLU106F, GLU112F, GLU121F, GLU22E, GLU30E, GLU42E, GLU43F, GLU53E, GLU58E, GLU63E, GLY102F, GLY116F, GLY125F, GLY209E, GLY31E, GLY49E, GLY58F, GLY82F, HIS103F, HIS26E, HIS30F, HIS32E, HIS35E, HIS38F, ILE29E, ILE38E, ILE45F, ILE48F, ILE90F, ILE92F, LEU100F, LEU104F, LEU107F, LEU108F, LEU111F, LEU114F, LEU123F, LEU128F, LEU138E, LEU151E, LEU204E, LEU207E, LEU20E, LEU25E, LEU27E, LEU34F, LEU39F, LEU40F, LEU42F, LEU43E, LEU50E, LEU50F, LEU55E, LEU61F, LEU64F, LEU65E, LEU69E, LEU74E, LEU83F, LEU93F, LYS176E, LYS202E, LYS24E, LYS46E, LYS73E, LYS77E, LYS94F, MET44E, MET68E, PHE118F, PHE124F, PHE148E, PHE211E, PHE232E, PHE59F, PHE88F, PHE89F, PRO205E, PRO210E, PRO214E, PRO39E, PRO48E, PRO52E, SER117F, SER119F, SER212E, SER215E, SER21E, SER34E, SER46F, SER51E, SER52F, SER60F, SER63F, SER66F, SER67E, SER87F, SER91F, SER96F, SER97F, SER98F, THR101F, THR109F, THR110F, THR113F, THR201E, THR32F, THR37E, THR55F, THR62E, TRP24F, TRP40E, TRP56E, TYR115F, TYR131F, TYR149E, TYR213E, TYR26F, TYR36E, TYR49F, TYR72E, VAL120F, VAL147E, VAL23E, VAL31F, VAL47E, VAL51F, VAL61E, VAL85F, VAL86F
• E-K: ALA54E, ALA564K, ALA568K, ALA593K, ARG152E, ARG350E, ARG430E, ARG558K, ARG597K, ASN140E, ASN435E, ASN653K, CYS153E, GLN129E, GLN150E, GLN344E, GLN589K, GLN598K, GLU349E, GLU567K, GLU595K, GLU624K, GLU669K, GLY135E, GLY342E, GLY347E, GLY49E, GLY590K, GLY594K, HIS154E, HIS655K, HIS657K, ILE134E, ILE599K, LEU130E, LEU138E, LEU151E, LEU155E, LEU50E, LEU565K, LEU573K, LEU577K, LEU579K, LEU654K, LEU659K, LYS128E, LYS329E, LYS341E, LYS385E, LYS601K, LYS625K, MET137E, MET343E, PHE131E, PHE578K, PRO139E, PRO384E, PRO48E, PRO596K, PRO600K, SER105E, SER156E, SER345E, SER51E, SER569K, SER574K, SER575K, SER576K, THR136E, THR339E, THR570K, THR571K, TYR132E, TYR133E, TYR157E, TYR346E, TYR383E, TYR566K, TYR572K, TYR622K, VAL340E, VAL388E, VAL436E, VAL47E, VAL592K, VAL656K
• G-H: ALA126H, ALA25H, ALA33G, ALA41H, ALA45G, ALA54G, ALA59G, ALA62H, ALA66G, ALA80H, ALA99H, ARG105H, ARG130H, ARG152G, ARG208G, ARG35H, ARG57G, ARG71G, ARG78H, ARG95H, ASN127H, ASN129H, ASN44H, ASN53H, ASN60G, ASN65H, ASN70G, ASN72H, ASN81H, ASN84H, ASP122H, ASP203G, ASP206G, ASP28G, ASP47H, ASP57H, ASP64G, CYS153G, CYS29H, CYS79H, GLN150G, GLN33H, GLN37H, GLN54H, GLU106H, GLU112H, GLU121H, GLU22G, GLU30G, GLU42G, GLU43H, GLU53G, GLU58G, GLU63G, GLY102H, GLY116H, GLY125H, GLY209G, GLY31G, GLY49G, GLY58H, GLY82H, HIS103H, HIS26G, HIS30H, HIS32G, HIS35G, HIS38H, ILE29G, ILE38G, ILE45H, ILE48H, ILE75G, ILE90H, ILE92H, LEU100H, LEU104H, LEU107H, LEU108H, LEU111H, LEU114H, LEU123H, LEU128H, LEU138G, LEU151G, LEU204G, LEU207G, LEU20G, LEU25G, LEU27G, LEU34H, LEU39H, LEU40H, LEU42H, LEU43G, LEU50G, LEU50H, LEU55G, LEU61H, LEU64H, LEU65G, LEU69G, LEU74G, LEU83H, LEU93H, LYS176G, LYS202G, LYS24G, LYS46G, LYS73G, LYS77G, LYS94H, MET137G, MET44G, MET68G, PHE118H, PHE124H, PHE148G, PHE211G, PHE232G, PHE59H, PHE88H, PHE89H, PRO205G, PRO210G, PRO214G, PRO39G, PRO48G, PRO52G, PRO67H, SER117H, SER119H, SER212G, SER215G, SER21G, SER34G, SER46H, SER51G, SER52H, SER60H, SER63H, SER66H, SER67G, SER87H, SER91H, SER96H, SER97H, SER98H, THR101H, THR110H, THR113H, THR201G, THR32H, THR37G, THR41G, THR55H, THR62G, TRP24H, TRP40G, TRP56G, TYR115H, TYR131H, TYR149G, TYR213G, TYR26H, TYR36G, TYR49H, TYR72G, VAL120H, VAL147G, VAL23G, VAL31H, VAL47G, VAL51H, VAL61G, VAL85H, VAL86H
• G-U: GLU187G, GLU187U, LYS188G, LYS188U, LYS73G, LYS73U, LYS77G, LYS77U, SER79U, TYR76U
• G-V: GLY80G, PHE124V, THR81G
• H-V: ASP122H, ASP122V, GLU121H, GLU121V
• I-J: ALA126J, ALA25J, ALA33I, ALA36J, ALA41J, ALA45I, ALA54I, ALA59I, ALA62J, ALA66I, ALA80J, ALA99J, ARG105J, ARG130J, ARG152I, ARG208I, ARG35J, ARG57I, ARG71I, ARG78J, ARG95J, ASN127J, ASN129J, ASN44J, ASN53J, ASN60I, ASN65J, ASN70I, ASN72J, ASN81J, ASN84J, ASP122J, ASP203I, ASP206I, ASP28I, ASP47J, ASP57J, ASP64I, CYS153I, CYS29J, CYS79J, GLN150I, GLN33J, GLN37J, GLN54J, GLU106J, GLU112J, GLU121J, GLU22I, GLU30I, GLU42I, GLU43J, GLU53I, GLU58I, GLU63I, GLY102J, GLY116J, GLY125J, GLY209I, GLY31I, GLY49I, GLY58J, GLY82J, HIS103J, HIS26I, HIS30J, HIS32I, HIS35I, HIS38J, ILE29I, ILE38I, ILE45J, ILE48J, ILE90J, ILE92J, LEU100J, LEU104J, LEU107J, LEU108J, LEU111J, LEU114J, LEU123J, LEU128J, LEU138I, LEU151I, LEU204I, LEU207I, LEU20I, LEU25I, LEU27I, LEU34J, LEU39J, LEU40J, LEU42J, LEU43I, LEU50I, LEU50J, LEU55I, LEU61J, LEU64J, LEU65I, LEU69I, LEU74I, LEU83J, LEU93J, LYS176I, LYS202I, LYS24I, LYS46I, LYS73I, LYS77I, LYS94J, MET137I, MET44I, MET68I, PHE118J, PHE124J, PHE148I, PHE211I, PHE232I, PHE59J, PHE88J, PHE89J, PRO205I, PRO210I, PRO214I, PRO39I, PRO48I, PRO52I, PRO67J, SER119J, SER212I, SER215I, SER21I, SER34I, SER46J, SER51I, SER52J, SER60J, SER63J, SER67I, SER87J, SER91J, SER96J, SER97J, SER98J, THR101J, THR110J, THR113J, THR201I, THR32J, THR37I, THR55J, THR62I, TRP24J, TRP40I, TRP56I, TYR115J, TYR131J, TYR149I, TYR213I, TYR26J, TYR36I, TYR49J, TYR72I, VAL120J, VAL147I, VAL23I, VAL31J, VAL47I, VAL51J, VAL61I, VAL85J, VAL86J
• I-S: LYS73I, LYS73S, LYS77I, LYS77S, SER79S
• I-T: GLU121T, LYS77I
• J-S: ALA126J, GLY80S, PHE124J, THR81S
• J-T: ASP122J, ASP122T, GLU121J, GLU121T
• K-L: ALA126L, ALA25L, ALA33K, ALA36L, ALA41L, ALA45K, ALA54K, ALA59K, ALA62L, ALA66K, ALA80L, ALA99L, ARG105L, ARG130L, ARG152K, ARG208K, ARG35L, ARG57K, ARG71K, ARG78L, ARG95L, ASN127L, ASN129L, ASN44L, ASN53L, ASN60K, ASN65L, ASN70K, ASN72L, ASN81L, ASN84L, ASP122L, ASP203K, ASP206K, ASP28K, ASP47L, ASP57L, ASP64K, CYS153K, CYS28L, CYS29L, CYS79L, GLN150K, GLN33L, GLN37L, GLN54L, GLU106L, GLU121L, GLU22K, GLU30K, GLU42K, GLU43L, GLU53K, GLU58K, GLU63K, GLY102L, GLY116L, GLY125L, GLY209K, GLY31K, GLY49K, GLY58L, GLY82L, HIS103L, HIS26K, HIS30L, HIS32K, HIS35K, HIS38L, ILE29K, ILE38K, ILE45L, ILE48L, ILE90L, ILE92L, LEU100L, LEU104L, LEU107L, LEU108L, LEU111L, LEU114L, LEU123L, LEU128L, LEU138K, LEU151K, LEU204K, LEU207K, LEU20K, LEU25K, LEU27K, LEU34L, LEU39L, LEU40L, LEU42L, LEU43K, LEU50K, LEU50L, LEU55K, LEU61L, LEU64L, LEU65K, LEU69K, LEU74K, LEU83L, LEU93L, LYS176K, LYS202K, LYS24K, LYS46K, LYS73K, LYS77K, LYS94L, MET44K, MET68K, PHE118L, PHE124L, PHE148K, PHE211K, PHE232K, PHE59L, PHE88L, PHE89L, PRO205K, PRO210K, PRO214K, PRO39K, PRO48K, PRO52K, SER117L, SER119L, SER212K, SER215K, SER21K, SER34K, SER46L, SER51K, SER52L, SER60L, SER63L, SER66L, SER67K, SER87L, SER91L, SER96L, SER97L, SER98L, THR101L, THR110L, THR113L, THR201K, THR32L, THR37K, THR55L, THR62K, TRP24L, TRP40K, TRP56K, TYR115L, TYR131L, TYR149K, TYR213K, TYR26L, TYR36K, TYR49L, TYR72K, VAL120L, VAL23K, VAL31L, VAL47K, VAL51L, VAL61K, VAL85L, VAL86L
• M-N: ALA126N, ALA25N, ALA33M, ALA36N, ALA41N, ALA45M, ALA54M, ALA59M, ALA62N, ALA66M, ALA80N, ALA99N, ARG105N, ARG130N, ARG152M, ARG208M, ARG35N, ARG57M, ARG71M, ARG78N, ARG95N, ASN129N, ASN44N, ASN53N, ASN60M, ASN65N, ASN70M, ASN81N, ASN84N, ASP122N, ASP203M, ASP206M, ASP28M, ASP47N, ASP64M, CYS153M, CYS29N, CYS56N, CYS79N, GLN150M, GLN33N, GLN37N, GLN54N, GLU106N, GLU112N, GLU121N, GLU22M, GLU30M, GLU42M, GLU43N, GLU53M, GLU58M, GLU63M, GLY102N, GLY116N, GLY125N, GLY209M, GLY31M, GLY49M, GLY58N, GLY82N, HIS103N, HIS26M, HIS30N, HIS32M, HIS35M, HIS38N, ILE29M, ILE38M, ILE45N, ILE48N, ILE90N, ILE92N, LEU100N, LEU104N, LEU107N, LEU108N, LEU111N, LEU114N, LEU123N, LEU128N, LEU138M, LEU151M, LEU204M, LEU207M, LEU20M, LEU25M, LEU27M, LEU34N, LEU39N, LEU40N, LEU42N, LEU43M, LEU50M, LEU50N, LEU55M, LEU61N, LEU64N, LEU65M, LEU69M, LEU74M, LEU83N, LEU93N, LYS202M, LYS24M, LYS46M, LYS73M, LYS77M, LYS94N, MET137M, MET44M, MET68M, PHE118N, PHE124N, PHE148M, PHE211M, PHE232M, PHE59N, PHE88N, PHE89N, PRO205M, PRO210M, PRO214M, PRO27N, PRO39M, PRO48M, PRO52M, PRO67N, SER117N, SER119N, SER212M, SER215M, SER21M, SER34M, SER46N, SER51M, SER52N, SER60N, SER63N, SER66N, SER67M, SER87N, SER91N, SER96N, SER97N, SER98N, THR101N, THR109N, THR110N, THR113N, THR201M, THR32N, THR37M, THR55N, THR62M, TRP24N, TRP40M, TRP56M, TYR115N, TYR131N, TYR149M, TYR213M, TYR26N, TYR36M, TYR49N, TYR72M, VAL120N, VAL147M, VAL23M, VAL31N, VAL47M, VAL51N, VAL61M, VAL85N, VAL86N
• M-Q: ARG152M, ARG597Q, GLN344M, GLU349M, GLU567Q, GLU595Q, GLU624Q, GLY135M, HIS655Q, ILE134M, LYS128M, LYS341M, LYS385M, LYS601Q, SER569Q, TYR572Q
• O-P: ALA126P, ALA25P, ALA33O, ALA41P, ALA45O, ALA54O, ALA59O, ALA62P, ALA66O, ALA80P, ALA99P, ARG105P, ARG130P, ARG152O, ARG208O, ARG35P, ARG57O, ARG71O, ARG78P, ARG95P, ASN127P, ASN129P, ASN44P, ASN53P, ASN60O, ASN65P, ASN70O, ASN72P, ASN81P, ASN84P, ASP122P, ASP203O, ASP206O, ASP28O, ASP47P, ASP57P, ASP64O, CYS28P, CYS29P, CYS79P, GLN150O, GLN33P, GLN37P, GLN54P, GLU106P, GLU112P, GLU121P, GLU22O, GLU30O, GLU42O, GLU43P, GLU53O, GLU58O, GLU63O, GLY102P, GLY116P, GLY125P, GLY209O, GLY31O, GLY49O, GLY58P, GLY82P, HIS103P, HIS26O, HIS30P, HIS32O, HIS35O, HIS38P, ILE29O, ILE38O, ILE45P, ILE48P, ILE75O, ILE90P, ILE92P, LEU100P, LEU104P, LEU107P, LEU108P, LEU111P, LEU114P, LEU123P, LEU128P, LEU138O, LEU151O, LEU204O, LEU207O, LEU20O, LEU25O, LEU27O, LEU34P, LEU39P, LEU40P, LEU42P, LEU43O, LEU50O, LEU50P, LEU55O, LEU61P, LEU64P, LEU65O, LEU69O, LEU74O, LEU83P, LEU93P, LYS202O, LYS24O, LYS46O, LYS73O, LYS77O, LYS94P, MET44O, MET68O, PHE118P, PHE124P, PHE148O, PHE211O, PHE232O, PHE59P, PHE88P, PHE89P, PRO205O, PRO210O, PRO214O, PRO39O, PRO48O, PRO52O, PRO67P, SER119P, SER212O, SER215O, SER21O, SER34O, SER46P, SER51O, SER52P, SER60P, SER63P, SER66P, SER67O, SER87P, SER91P, SER96P, SER97P, SER98P, THR101P, THR109P, THR110P, THR113P, THR201O, THR32P, THR37O, THR55P, THR62O, TRP24P, TRP40O, TRP56O, TYR115P, TYR131P, TYR146O, TYR149O, TYR213O, TYR26P, TYR36O, TYR49P, TYR72O, VAL120P, VAL147O, VAL23O, VAL31P, VAL47O, VAL51P, VAL61O, VAL85P, VAL86P
• O-1: ARG152O, GLU349O, GLU5671, GLU5951, GLU6241, HIS6551, ILE134O, LYS128O, LYS341O, LYS385O, LYS6011, LYS6251, SER5691
• Q-R: ARG35R, ARG71Q, ARG95R, ASN81R, ASN84R, ASP206Q, ASP47R, ASP64Q, GLU121R, GLU43R, GLU53Q, GLY209Q, HIS103R, HIS26Q, HIS30R, HIS35Q, ILE48R, LEU50R, LYS24Q, LYS77Q, LYS94R, PHE211Q, TYR115R, VAL61Q
• S-T: ARG95T, ASN81T, ASN84T, ASP206S, ASP47T, ASP64S, GLN54T, GLU121T, GLU30S, GLU43T, GLU53S, GLU63S, HIS103T, HIS26S, HIS30T, HIS35S, ILE48T, LEU50T, LYS24S, LYS77S, LYS94T, PHE211S, TYR115T, VAL61S
• U-V: ARG35V, ARG95V, ASN81V, ASP206U, ASP47V, ASP64U, GLU121V, GLU22U, GLU43V, GLU53U, HIS103V, HIS26U, HIS30V, HIS35U, ILE48V, LYS24U, LYS77U, LYS94V, PHE211U, TYR115V, TYR26V, VAL61U
• W-X: ARG35X, ARG71W, ARG95X, ASN60W, ASN84X, ASP206W, ASP47X, ASP64W, GLN150W, GLN33X, GLU121X, GLU22W, GLU43X, GLU53W, GLY209W, HIS103X, HIS26W, HIS30X, HIS35W, ILE48X, LEU20W, LEU42X, LEU50X, LYS24W, LYS77W, LYS94X, PHE211W, TYR115X
• Y-Z: ARG95Z, ASN60Y, ASN81Z, ASP206Y, ASP47Z, ASP64Y, GLN33Z, GLU121Z, GLU43Z, GLU53Y, HIS103Z, HIS26Y, HIS30Z, HIS35Y, ILE48Z, LEU42Z, LYS24Y, LYS77Y, LYS94Z, PHE211Y, TYR115Z, VAL61Y
• Y-1: LYS731, LYS73Y, LYS771, LYS77Y
• Y-2: GLU1212, LYS77Y
• Z-1: GLU121Z, LYS771
• Z-2: ASP1222, ASP122Z, GLU1212, GLU121Z
• 1-2: ARG352, ARG711, ARG952, ASN601, ASN812, ASN842, ASP2061, ASP472, ASP641, GLN332, GLN542, GLU1212, GLU301, GLU432, GLU531, HIS1032, HIS261, HIS302, HIS351, ILE482, LEU201, LEU502, LYS241, LYS771, LYS942, PHE2111, SER462, TYR1152, VAL611
• 3-4: ARG954, ASN814, ASP2063, ASP474, ASP643, GLN1503, GLU1214, GLU434, GLU533, HIS1034, HIS263, HIS304, HIS353, ILE484, LYS243, LYS773, LYS944, PHE2113, SER464, TYR1154, VAL613
• 3-5: ASN703, LYS733, LYS735, LYS773, LYS775, SER795
• 3-6: GLY803, PHE1246
• 4-6: ASP1224, ASP1226, GLU1214, GLU1216
• 5-6: ARG715, ARG956, ASN816, ASN846, ASP2065, ASP476, ASP645, GLN546, GLU1216, GLU305, GLU436, GLU535, GLU635, GLY2095, HIS1036, HIS265, HIS306, HIS355, ILE486, LYS245, LYS775, LYS946, PHE2115, TYR1156, VAL615