3PFV

crystal structure of cbl-b tkb domain in complex with egfr py1069 peptide

• Total interactions analyzed: 6
• Total true interactions: 3
• Strongest Interaction:
  • Chains: B-D
  • Int. Res.: 50
  • Norm. En. per Res.: -2.9987
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-23.9619	15.9851	-146.163	-154.1398	119	9	7	7426	0	52	63
A-C	-19.1343	-4.3351	-109.449	-132.9183	48	11	0	3882	1	6	6
B-D	-20.0534	-18.4573	-111.422	-149.9327	50	6	0	4022	1	6	6

Interface residues

• A-B: ALA213A, ALA213B, ALA215A, ALA215B, ALA254A, ALA254B, ALA262A, ALA262B, ALA40B, ARG120A, ARG120B, ARG123A, ARG123B, ARG131A, ARG131B, ARG198A, ARG198B, ARG272A, ARG272B, ARG335A, ARG335B, ASN142A, ASN142B, ASN251A, ASN251B, ASP112A, ASP112B, ASP226A, ASP226B, ASP333A, ASP333B, GLN136B, GLN138A, GLN138B, GLN199A, GLN199B, GLN206A, GLN206B, GLU127A, GLU127B, GLU212A, GLU212B, GLY210A, GLY210B, GLY259A, GLY259B, HIS202A, HIS202B, HIS205A, HIS205B, HIS257A, HIS257B, ILE207A, ILE207B, LEU124B, LEU211A, LEU211B, LEU216A, LEU216B, LEU253A, LEU253B, LYS108B, LYS116A, LYS116B, LYS119A, LYS119B, LYS126A, LYS126B, LYS145A, LYS145B, LYS195A, LYS195B, LYS217A, LYS217B, LYS275A, LYS275B, MET115A, MET115B, MET214A, MET214B, MET261A, MET261B, PHE240A, PHE240B, PHE263A, PHE263B, PRO193A, PRO193B, PRO258A, PRO258B, PRO332A, PRO332B, PRO339A, PRO339B, SER137B, SER208A, SER208B, SER209A, SER209B, SER218A, SER218B, SER336A, SER336B, THR219A, THR219B, THR256A, THR256B, TRP194A, TRP194B, TRP250A, TRP250B, TYR227A, TYR227B, TYR260A, TYR260B, TYR337A, TYR337B, VAL255A, VAL255B
• A-C: ALA319A, ARG1068C, ARG286A, ARG291A, ARG325A, ASN69A, ASP1072C, ASP267A, ASP322A, CYS289A, GLN1067C, GLN308A, GLN318A, GLU268A, GLU326A, GLY1075C, GLY298A, GLY323A, GLY327A, HIS312A, ILE297A, ILE306A, ILE310A, ILE321A, LEU1066C, LEU307A, LEU320A, LYS270A, LYS314A, LYS68A, PHE328A, PRO1073C, PRO311A, PRO71A, PRO72A, SER1070C, SER1071C, SER324A, SER70A, THR1074C, THR265A, THR290A, THR301A, THR309A, TYR266A, TYR299A, TYR329A, TYR73A
• B-D: ALA1076D, ALA319B, ARG1068D, ARG286B, ARG291B, ARG325B, ASN313B, ASN69B, ASP1072D, ASP267B, ASP322B, CYS289B, GLN1067D, GLN308B, GLN318B, GLU268B, GLU326B, GLY1075D, GLY298B, GLY323B, GLY327B, HIS312B, ILE297B, ILE306B, ILE310B, ILE321B, LEU307B, LEU320B, LYS270B, LYS314B, LYS68B, PHE328B, PRO1073D, PRO311B, PRO71B, PRO72B, SER1070D, SER1071D, SER288B, SER324B, SER70B, THR1074D, THR265B, THR290B, THR301B, THR309B, TYR266B, TYR299B, TYR329B, TYR73B