3PCQ

femtosecond x-ray protein nanocrystallography

• Total interactions analyzed: 66
• Total true interactions: 28
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 129
  • Norm. En. per Res.: -5.2149
• Hub Node: A(9)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-99.5618	-45.8423	-1039.35	-1184.7541	329	53	24	39393	6	50	50
A-C	-35.8182	-29.6879	-112.008	-177.514	45	5	0	4378	6	8	8
A-D	-40.9693	-40.5399	-217.846	-299.3553	76	11	3	8141	4	17	12
A-E	-27.3505	0.0	-121.323	-148.6735	67	9	1	5068	0	6	8
A-F	-55.0986	-16.2371	-220.81	-292.1457	85	17	3	9129	1	21	11
A-I	0.0	0.0	-0.0009	-0.0009	2	0	0	3	0	0	0
A-J	0.0	-2.6195	-81.041	-83.6605	43	1	4	3529	0	2	5
A-K	0.0	0.0	-45.3302	-45.3302	48	1	4	2230	0	6	7
A-L	-18.44	-19.5551	-45.5136	-83.5087	48	7	2	2595	1	7	12
B-C	-57.045	-89.697	-186.976	-333.7179	86	10	3	8319	6	24	19
B-D	-54.2645	-22.1279	-133.491	-209.8833	80	14	1	6041	3	24	19
B-E	-25.4803	4.9964	-86.7806	-107.2646	34	3	1	3112	0	7	8
B-F	-46.3364	-28.9455	-268.601	-343.8829	116	13	9	11859	6	29	33
B-I	-32.4788	14.9296	-242.169	-259.7182	72	6	5	8179	3	11	4
B-J	-7.3463	-4.1594	-22.353	-33.8587	17	0	0	1050	1	2	2
B-L	-29.6894	12.685	-102.785	-119.7894	60	4	3	4684	0	8	11
B-M	-17.1654	6.3959	-239.151	-249.9205	94	8	14	10671	0	8	5
B-X	0.0	0.0	-89.298	-89.298	48	3	2	3141	0	3	3
C-D	-103.0216	-121.3335	-448.371	-672.7261	129	26	13	17044	6	45	37
C-E	-48.8335	-22.2981	-123.979	-195.1105	60	4	0	4948	1	12	10
D-E	-10.5442	0.0	-21.3263	-31.8705	18	3	0	1006	0	2	3
D-F	0.0	0.0	-0.1419	-0.1419	5	0	0	31	0	0	0
D-L	-26.5177	0.0	-121.277	-147.7947	46	3	4	4296	0	4	2
E-F	-4.8945	-3.2956	-62.3625	-70.5527	28	1	1	2389	0	12	9
F-J	-62.1492	-37.694	-187.305	-287.1482	83	13	7	7733	1	8	10
F-X	0.0	0.0	-18.3084	-18.3084	14	3	0	780	0	0	0
I-L	-16.7852	-7.6118	-51.2353	-75.6322	33	1	4	2108	0	2	0
I-M	-9.5204	0.0	-43.9956	-53.5159	24	2	4	1776	0	2	0

Interface residues

• A-B: ALA102B, ALA420B, ALA439A, ALA448B, ALA467A, ALA544B, ALA547B, ALA560A, ALA578B, ALA581B, ALA585B, ALA640A, ALA643A, ALA653B, ALA656A, ALA658A, ALA664B, ALA668A, ALA671A, ALA684A, ALA687B, ALA705B, ALA707A, ALA721A, ALA745A, ALA98B, ALA99B, ARG18B, ARG437A, ARG466A, ARG470A, ARG564A, ARG570B, ARG583A, ARG627B, ARG651A, ARG674B, ARG690B, ARG694A, ARG712B, ARG720A, ARG728A, ASN443B, ASN445A, ASN462A, ASN591B, ASN633B, ASN638A, ASN639B, ASN642B, ASN647A, ASN647B, ASN709A, ASP101B, ASP438A, ASP444B, ASP463A, ASP473A, ASP546B, ASP566B, ASP575B, ASP579A, ASP580B, ASP593A, ASP628B, ASP652A, ASP92B, CYS448A, CYS565B, CYS574B, CYS578A, CYS587A, GLN123A, GLN416B, GLN472A, GLN588A, GLN636B, GLN641A, GLN657A, GLN660A, GLN678B, GLN698A, GLN718A, GLN94B, GLU419B, GLU679B, GLU682B, GLU689B, GLU699A, GLU702A, GLY122A, GLY124A, GLY450B, GLY469A, GLY543B, GLY549B, GLY556A, GLY567B, GLY569B, GLY571B, GLY572B, GLY580A, GLY582A, GLY584A, GLY585A, GLY598A, GLY624B, GLY640B, GLY645B, GLY648A, GLY663A, GLY666A, GLY666B, GLY673A, GLY675B, GLY678A, GLY693A, GLY695A, GLY727A, GLY731A, GLY96B, HIS417B, HIS424B, HIS436A, HIS442B, HIS443A, HIS461A, HIS594A, HIS660B, HIS680A, HIS688B, HIS708A, ILE120A, ILE125A, ILE421B, ILE422B, ILE440A, ILE441A, ILE449A, ILE539B, ILE552A, ILE566A, ILE576B, ILE638B, ILE644A, ILE646A, ILE662A, ILE671B, ILE681B, ILE701A, ILE704A, ILE708B, ILE724A, ILE725A, ILE90B, LEU126A, LEU425B, LEU430B, LEU437B, LEU444A, LEU538B, LEU540B, LEU545B, LEU551A, LEU552B, LEU553A, LEU558A, LEU565A, LEU572A, LEU584B, LEU597A, LEU622B, LEU626B, LEU630B, LEU632B, LEU637B, LEU649B, LEU650A, LEU654A, LEU657B, LEU661B, LEU669A, LEU670B, LEU674A, LEU675A, LEU677A, LEU680B, LEU684B, LEU687A, LEU690A, LEU700A, LEU706B, LEU711A, LEU716B, LEU722A, LYS418B, LYS454B, LYS542B, LYS551B, LYS555A, LYS556B, LYS569A, LYS710A, LYS97B, MET465A, MET474A, MET553B, MET623B, MET655B, MET668B, MET688A, PHE103B, PHE449B, PHE456A, PHE468A, PHE559A, PHE559B, PHE563B, PHE576A, PHE582B, PHE587B, PHE596A, PHE600A, PHE644B, PHE656B, PHE658B, PHE667B, PHE669B, PHE676A, PHE681A, PHE685A, PHE689A, PHE691A, PHE719B, PHE95B, PRO452B, PRO471A, PRO554B, PRO564B, PRO568B, PRO577A, PRO581A, PRO643B, PRO93B, SER423B, SER426B, SER429B, SER442A, SER550B, SER562A, SER563A, SER577B, SER590A, SER634B, SER635B, SER642A, SER650B, SER659A, SER664A, SER667A, SER670A, SER672B, SER686A, SER692A, SER703A, SER707B, SER723A, THR16B, THR451B, THR464A, THR46A, THR535B, THR573B, THR586A, THR645A, THR646B, THR665B, THR683B, THR691B, THR726B, THR742A, TRP427B, TRP446A, TRP588B, TRP595B, TRP601A, TRP615A, TRP625B, TRP631B, TRP649A, TRP654B, TRP655A, TRP663B, TRP673B, TRP677B, TRP683A, TRP686B, TRP697A, TRP706A, TYR22B, TYR440B, TYR459A, TYR583B, TYR621B, TYR629B, TYR641B, TYR665A, TYR672A, TYR676B, TYR696A, TYR735A, VAL100B, VAL117A, VAL121A, VAL441B, VAL445B, VAL446B, VAL447B, VAL460A, VAL541B, VAL548A, VAL589A, VAL651B, VAL661A, VAL685B, VAL704B, VAL705A, VAL709B, VAL732A
• A-C: ALA19C, ALA79C, ARG52C, ARG564A, ARG583A, ARG65C, ARG74C, ASN571A, ASP568A, ASP579A, CYS20C, CYS47C, CYS50C, CYS578A, GLU54C, GLU71C, GLY49C, GLY580A, GLY582A, GLY584A, GLY585A, GLY77C, HIS2C, ILE566A, LEU565A, LEU572A, LEU68C, LEU78C, LYS51C, LYS569A, MET76C, PHE576A, PRO21C, PRO567A, PRO581A, SER563A, SER75C, THR22C, THR55C, THR586A, THR72C, THR73C, TYR80C, VAL48C, VAL66C
• A-D: ALA423A, ALA439A, ALA44D, ALA46D, ALA47D, ALA570A, ALA59D, ALA66D, ALA69D, ARG432A, ARG435A, ARG437A, ARG561A, ARG564A, ARG583A, ARG60D, ARG75D, ASN425A, ASN427A, ASN428A, ASN571A, ASP421A, ASP431A, ASP438A, ASP568A, ASP579A, CYS64D, GLN37D, GLN426A, GLN63D, GLN70D, GLN71D, GLU40D, GLU62D, GLY11D, GLY12D, GLY15D, GLY16D, GLY45D, HIS436A, ILE440A, ILE441A, ILE566A, LEU17D, LEU18D, LEU430A, LEU434A, LEU558A, LEU565A, LEU572A, LEU65D, LEU67D, LEU9D, LYS569A, LYS61D, MET416A, MET41D, MET424A, MET49D, PHE39D, PHE559A, PHE58D, PRO422A, PRO42D, PRO567A, SER13D, SER19D, SER562A, SER563A, THR14D, THR43D, TYR10D, TYR420A, VAL38D, VAL433A, VAL48D
• A-E: ALA39A, ALA52E, ALA714A, ALA716A, ALA721A, ARG39E, ARG40A, ARG575A, ARG694A, ARG720A, ARG728A, ASN44E, ASN50A, ASN56E, ASN709A, ASP41E, ASP579A, CYS578A, GLN43A, GLN698A, GLN718A, GLN726A, GLU19E, GLU699A, GLU702A, GLY41A, GLY47E, GLY50E, GLY54E, GLY580A, GLY727A, ILE48A, ILE701A, ILE717A, ILE724A, ILE725A, LEU38A, LEU51A, LEU54A, LEU572A, LEU722A, LYS42E, PHE576A, PRO42A, PRO577A, PRO715A, PRO719A, SER49E, SER51E, SER53E, SER590A, SER723A, THR37A, THR44A, THR45A, THR46A, THR46E, THR586A, TRP16E, TRP47A, TRP49A, TYR15E, TYR45E, TYR48E, VAL43E, VAL55E, VAL705A
• A-F: ALA131F, ALA26F, ALA29A, ALA707A, ALA714A, ALA716A, ALA83F, ALA94F, ARG141F, ARG34F, ARG40A, ARG82F, ARG89F, ASN134F, ASN23F, ASN709A, ASN90F, ASN95F, ASP133F, ASP27F, GLN123A, GLN43A, GLN718A, GLU123F, GLU128F, GLU135F, GLU699A, GLU702A, GLU93F, GLU96F, GLU98F, GLY122A, GLY124A, GLY127F, GLY32A, GLY41A, GLY666A, GLY78F, GLY81F, HIS708A, ILE100F, ILE120A, ILE125A, ILE136F, ILE48A, ILE717A, ILE86F, ILE99F, LEU124F, LEU129F, LEU51A, LEU711A, LEU85F, LYS132F, LYS30A, LYS710A, LYS712A, LYS97F, PRO119A, PRO31A, PRO42A, PRO715A, PRO719A, SER126F, SER139F, SER30F, SER703A, SER91F, THR130F, THR137F, THR24F, THR25F, THR44A, THR45A, TRP118A, TRP28A, TRP47A, TRP706A, TRP79F, VAL121A, VAL138F, VAL22F, VAL705A, VAL713A, VAL88F
• A-I: MET1I, PHE468A
• A-J: ALA11J, ALA29A, ARG31J, ASN30J, ASP35J, GLN123A, GLU26A, GLU28J, GLY122A, HIS3J, HIS52A, ILE120A, ILE27J, ILE48A, ILE717A, LEU26J, LEU36J, LEU51A, LEU5J, LEU8J, LYS27A, LYS2J, LYS30A, MET1J, PHE25A, PHE29J, PHE32J, PHE4J, PRO119A, PRO12J, PRO31A, PRO34J, SER24A, SER9J, THR10J, THR6J, TRP118A, TRP28A, TRP47A, TYR33J, TYR7J, VAL121A, VAL13J
• A-K: ALA61K, ALA70K, ALA71K, ARG316A, ARG37K, ASN318A, GLN35K, GLU327A, GLU58K, GLY320A, GLY322A, GLY38K, GLY40K, GLY42K, GLY66K, GLY72K, HIS313A, HIS323A, HIS67K, ILE20K, ILE310A, ILE321A, LEU21K, LEU24K, LEU43K, LEU56K, LEU59K, LEU60K, LEU68K, LEU69K, LYS39K, PHE270A, PHE65K, PRO41K, PRO57K, SER324A, SER36K, SER64K, SER75K, THR269A, THR317A, THR62K, TRP272A, TRP319A, TYR32K, VAL306A, VAL73K, VAL74K
• A-L: ALA439A, ARG432A, ARG435A, ARG437A, ARG470A, ARG564A, ARG69L, ASN427A, ASP438A, ASP473A, ASP70L, GLN472A, GLN481A, GLY15L, GLY334A, GLY338A, GLY479A, GLY66L, HIS16L, HIS436A, HIS443A, HIS461A, ILE21L, ILE480A, LEU17L, LEU434A, LEU482A, LEU4L, LEU65L, LEU68L, LYS64L, LYS6L, MET465A, MET474A, PHE13L, PHE336A, PHE475A, PRO12L, PRO20L, PRO335A, PRO471A, PRO67L, PRO7L, THR19L, THR337A, VAL14L, VAL433A, VAL5L
• B-C: ALA12B, ALA1C, ALA56C, ALA705B, ALA70C, ALA79C, ARG18B, ARG19B, ARG52C, ARG570B, ARG65C, ARG674B, ARG74C, ASP10B, ASP14B, ASP555B, ASP558B, ASP566B, ASP60C, ASP701B, CYS50C, CYS565B, CYS57C, GLN13B, GLN678B, GLN9B, GLU54C, GLU679B, GLU682B, GLU689B, GLU71C, GLY49C, GLY560B, GLY567B, GLY569B, GLY571B, GLY572B, GLY69C, GLY77C, HIS2C, ILE64C, ILE681B, ILE708B, LEU11B, LEU552B, LEU62C, LEU68C, LEU706B, LEU78C, LYS51C, LYS551B, LYS556B, LYS557B, LYS702B, MET553B, MET76C, PHE559B, PHE563B, PHE61C, PRO15B, PRO554B, PRO564B, PRO568B, PRO703B, SER550B, SER707B, SER75C, SER8B, THR16B, THR17B, THR3C, THR55C, THR573B, THR59C, THR683B, THR72C, THR73C, TRP686B, TRP699B, TYR22B, TYR67C, TYR7C, TYR80C, VAL66C, VAL685B, VAL704B
• B-D: ALA20D, ALA21D, ALA404B, ALA687B, ARG117D, ARG399B, ARG548B, ARG60D, ARG690B, ARG698B, ASN122D, ASN124D, ASN331B, ASN40B, ASP10B, ASP22D, ASP400B, ASP402B, ASP555B, ASP558B, GLN121D, GLN127D, GLN405B, GLU24D, GLU25D, GLU31B, GLU38B, GLU39B, GLU682B, GLU689B, GLY120D, GLY15D, GLY16D, GLY35B, GLY560B, HIS334B, HIS33B, HIS688B, ILE119D, LEU128D, LEU164B, LEU17D, LEU18D, LEU333B, LEU397B, LEU41B, LYS129D, LYS134D, LYS168B, LYS556B, LYS557B, LYS702B, MET36B, MET553B, PHE130D, PHE30B, PHE396B, PHE559B, PRO123D, PRO125D, PRO135D, PRO15B, PRO403B, PRO554B, SER126D, SER13D, SER19D, SER32B, SER332B, THR14D, THR23D, THR37B, THR683B, TRP686B, TRP699B, TYR136D, TYR401B, TYR42B, VAL398B, VAL685B
• B-E: ARG11E, ARG570B, ASN18E, ASN44E, ASP555B, CYS574B, GLU13E, GLU19E, GLY47E, GLY50E, GLY567B, GLY569B, GLY571B, GLY572B, ILE576B, LEU552B, LYS42E, LYS551B, LYS557B, MET553B, PRO12E, PRO554B, PRO568B, SER14E, SER49E, SER51E, SER550B, THR46E, THR573B, TRP16E, TYR15E, TYR17E, TYR45E, TYR48E
• B-F: ALA13F, ALA18F, ALA20F, ALA21F, ALA3F, ALA420B, ALA468B, ALA547B, ALA613B, ARG141F, ARG17F, ARG34F, ARG413B, ARG548B, ARG56F, ARG59F, ASN23F, ASN616B, ASP133F, ASP1F, ASP412B, ASP46F, ASP546B, ASP54F, ASP555B, ASP62F, CYS43F, CYS8F, GLN416B, GLN455B, GLN464B, GLU419B, GLU453B, GLU459B, GLU45F, GLU617B, GLY31F, GLY44F, GLY450B, GLY476B, GLY47F, GLY4F, GLY519B, GLY521B, GLY549B, GLY55F, HIS417B, HIS435B, HIS442B, HIS50F, HIS527B, ILE136F, ILE422B, ILE456B, ILE458B, ILE518B, LEU397B, LEU411B, LEU415B, LEU42F, LEU439B, LEU457B, LEU473B, LEU474B, LEU48F, LEU51F, LEU545B, LEU552B, LEU5F, LEU71F, LYS418B, LYS454B, LYS551B, LYS556B, LYS557B, MET553B, PHE14F, PHE35F, PHE431B, PHE449B, PHE462B, PHE465B, PHE477B, PHE523B, PHE63F, PHE70F, PRO140F, PRO403B, PRO452B, PRO460B, PRO49F, PRO520B, PRO554B, SER139F, SER30F, SER550B, THR137F, THR24F, THR25F, THR451B, THR517B, THR620B, TYR38F, TYR401B, TYR475B, TYR621B, VAL138F, VAL22F, VAL2F, VAL414B, VAL446B, VAL447B, VAL461B, VAL52F, VAL53F, VAL612B
• B-I: ALA108B, ALA12B, ALA1B, ALA23B, ALA38I, ALA68B, ALA6I, ALA7I, ALA89B, ALA99B, ARG19B, ASN110B, ASP101B, ASP701B, ASP92B, CYS19I, GLN70B, GLN94B, GLN9B, GLU35I, GLU37I, GLY36I, GLY3I, GLY71B, GLY96B, HIS66B, HIS88B, ILE13I, ILE15I, ILE20B, ILE24B, ILE34I, ILE86B, ILE90B, LEU10I, LEU30I, LEU32I, LYS3B, LYS6B, LYS700B, LYS97B, MET1I, MET2I, PHE103B, PHE14I, PHE31I, PHE4B, PHE65B, PHE7B, PHE95B, PHE9I, PRO111B, PRO11I, PRO16I, PRO5B, PRO93B, SER109B, SER4I, SER8I, THR104B, THR17B, THR2B, TRP12I, TRP20I, TRP21B, TRP699B, TRP69B, TRP91B, TYR33I, TYR5I, VAL100B, VAL112B
• B-J: ASN30J, ASN443B, ASP35J, GLN455B, GLU453B, HIS442B, ILE456B, ILE458B, LEU36J, LEU37J, LEU457B, LYS454B, PHE38J, PRO34J, PRO452B, THR451B, VAL446B
• B-L: ALA1B, ALA36L, ALA687B, ALA694B, ARG19B, ARG46L, ARG690B, ARG698B, ASN695B, ASN9L, ASP109L, ASP701B, GLN102L, GLN94B, GLU689B, GLY15L, GLY32L, HIS16L, HIS54L, HIS688B, ILE21L, ILE31L, LEU111L, LEU17L, LEU34L, LEU693B, LEU696B, LEU93L, LEU98L, LYS103L, LYS112L, LYS28L, LYS3B, LYS700B, LYS702B, PHE101L, PHE120L, PHE13L, PHE30L, PRO15B, PRO35L, PRO67L, PRO692B, PRO93B, SER100L, SER22L, THR19L, THR2B, THR691B, TRP117L, TRP686B, TRP699B, TYR37L, TYR8L, TYR96L, VAL14L, VAL27L, VAL50L, VAL697B, VAL99L
• B-M: ALA11M, ALA138B, ALA145B, ALA148B, ALA151B, ALA15M, ALA19M, ALA22M, ALA2M, ALA47B, ALA54B, ALA68B, ARG129B, ARG161B, ARG24M, ASN131B, ASP133B, ASP5M, GLN136B, GLN157B, GLN43B, GLN70B, GLN75B, GLN7M, GLU28M, GLU74B, GLY132B, GLY152B, GLY51B, GLY71B, HIS155B, HIS28B, HIS49B, HIS52B, HIS66B, ILE139B, ILE143B, ILE14M, ILE45B, ILE55B, LEU12M, LEU134B, LEU141B, LEU142B, LEU144B, LEU147B, LEU149B, LEU154B, LEU156B, LEU16M, LEU17M, LEU21M, LEU25M, LEU29M, LEU3M, LEU53B, LEU58B, LEU64B, LYS159B, LYS31M, LYS3B, LYS44B, LYS6B, MET1M, PHE140B, PHE150B, PHE23M, PHE30B, PHE46B, PHE4B, PHE50B, PHE65B, PHE7B, PRO158B, PRO18M, PRO5B, SER146B, SER26M, SER48B, SER61B, THR130B, THR27M, THR4M, THR6M, TRP153B, TRP69B, TYR135B, TYR30M, TYR9M, VAL10M, VAL13M, VAL20M, VAL67B, VAL8M
• B-X: ALA27X, ALA28X, ALA463B, ALA468B, ALA469B, ALA488B, ARG12X, ARG413B, ASN319B, ASN483B, ASP478B, ASP485B, GLN464B, GLU315B, GLU459B, GLY316B, GLY32X, ILE33X, ILE466B, ILE487B, LEU18X, LEU19X, LEU25X, LEU34X, LEU480B, LEU481B, LYS35X, MET320B, PHE11X, PHE14X, PHE309B, PHE318B, PHE31X, PHE462B, PHE465B, PHE477B, PRO317B, PRO460B, PRO7X, SER486B, SER489B, THR479B, TRP15X, TYR29X, TYR30X, VAL26X, VAL314B, VAL461B
• C-D: ALA111D, ALA19C, ALA20D, ALA21D, ALA35C, ALA39C, ALA59D, ALA66D, ALA69D, ALA79C, ARG109D, ARG117D, ARG18C, ARG43C, ARG52C, ARG60D, ARG65C, ARG73D, ARG74C, ARG84D, ASN106D, ASN113D, ASN122D, ASP137D, ASP23C, ASP46C, ASP60C, ASP8C, ASP98D, CYS10C, CYS13C, CYS16C, CYS20C, CYS47C, CYS50C, CYS64D, GLN121D, GLN15C, GLN37C, GLN63D, GLN70D, GLU103D, GLU110D, GLU24D, GLU25D, GLU26C, GLU45C, GLU54C, GLU62D, GLY108D, GLY120D, GLY12C, GLY15D, GLY16D, GLY36C, GLY69C, GLY77C, HIS2C, HIS95D, ILE119D, ILE38C, ILE64C, ILE6C, ILE82D, ILE85D, ILE94D, LEU17D, LEU18D, LEU25C, LEU62C, LEU65D, LEU68C, LEU78C, LEU93D, LYS104D, LYS107D, LYS134D, LYS26D, LYS5C, LYS61D, LYS97D, MET27C, MET76C, PHE101D, PHE58D, PHE61C, PHE86D, PRO102D, PRO116D, PRO123D, PRO135D, PRO138D, PRO21C, PRO29C, PRO42C, PRO96D, SER114D, SER118D, SER19D, SER40C, SER41C, SER63C, SER75C, THR14C, THR22C, THR23D, THR3C, THR43D, THR44C, THR59C, THR73C, THR9C, TRP30C, TYR136D, TYR27D, TYR67C, TYR7C, TYR80C, TYR80D, VAL100D, VAL105D, VAL112D, VAL115D, VAL17C, VAL24C, VAL28C, VAL48C, VAL4C, VAL66C
• C-E: ALA35C, ALA56C, ALA61E, ARG11E, ARG52C, ASN44E, ASN56E, ASN58E, ASN59E, ASP27E, ASP31C, ASP60C, ASP8C, CYS10C, CYS33C, CYS50C, CYS57C, GLN28E, GLU13E, GLU54C, GLU64E, GLY31E, GLY32C, GLY36C, GLY47E, ILE11C, ILE37E, ILE38C, ILE9E, LEU62C, LYS33E, LYS34C, LYS51C, PHE40E, PHE60E, PHE61C, PRO12E, PRO30E, PRO35E, PRO58C, SER14E, SER49E, SER63C, THR29E, THR46E, THR55C, THR57E, THR59C, THR9C, TRP16E, TRP30C, TYR15E, TYR17E, TYR34E, TYR45E, TYR48E, TYR7C, VAL26E, VAL32E, VAL55E
• D-E: ALA61E, ARG117D, ARG11E, ASN122D, GLN121D, GLU13E, GLU64E, GLY120D, HIS63E, ILE119D, LEU10E, LYS33E, PRO116D, PRO12E, SER118D, SER14E, TYR34E, VAL115D
• D-F: ARG141F, ASN124D, GLY120D, ILE119D, PRO140F
• D-L: ALA21D, ALA47D, ALA59D, ASN54D, ASP11L, ASP22D, GLN6D, GLU24D, GLY10L, GLY11D, GLY12D, GLY15D, GLY15L, GLY16D, HIS16L, LEU17D, LEU17L, LEU18D, LEU55D, LEU9D, LYS103L, LYS26D, LYS6L, MET41D, PHE13L, PHE39D, PHE58D, PRO12L, PRO42D, PRO7D, PRO7L, PRO8D, SER13D, SER18L, SER19D, THR14D, THR19L, THR43D, TRP31D, TYR10D, TYR27D, TYR57D, TYR8L, VAL14L, VAL56D, VAL5L
• E-F: ARG11E, ARG141F, ASN134F, ASN18E, ASN90F, ASN95F, ASP133F, ASP41E, GLU135F, GLU13E, GLU19E, ILE136F, ILE9E, LYS132F, LYS42E, LYS8E, PRO12E, PRO140F, SER139F, SER14E, THR137F, TRP16E, TYR15E, TYR17E, TYR45E, VAL138F, VAL20E, VAL43E
• F-J: ALA106F, ALA11J, ALA15J, ALA26F, ALA41F, ALA60F, ARG31J, ARG34F, ARG37F, ARG56F, ARG59F, ASN23F, ASN30J, ASP102F, ASP27F, ASP35J, ASP62F, CYS8F, GLN40F, GLU36F, GLU96F, GLU98F, GLY31F, GLY61F, HIS39J, HIS50F, ILE100F, ILE101F, ILE107F, ILE27J, ILE65F, ILE73F, ILE77F, ILE99F, LEU14J, LEU26J, LEU36J, LEU37J, LEU41J, LEU42F, LEU48F, LEU51F, LEU57F, LEU5J, LEU64F, LEU69F, LEU8J, LYS33F, LYS97F, MET110F, MET19J, PHE14F, PHE29J, PHE32J, PHE35F, PHE38J, PHE63F, PRO104F, PRO12J, PRO34J, PRO40J, PRO49F, PRO66F, SER30F, SER39F, SER58F, SER9J, THR10J, THR22J, THR24F, THR25F, THR6J, TRP18J, TRP76F, TYR33J, TYR38F, TYR7J, TYR84F, VAL103F, VAL13J, VAL22F, VAL52F, VAL80F
• F-X: ALA27X, ALA3F, ARG56F, ARG59F, ASP54F, GLY32X, GLY55F, LEU57F, PHE31X, SER58F, TYR30X, VAL2F, VAL52F, VAL53F
• I-L: ALA38I, ALA84L, ALA91L, ALA94L, ALA95L, CYS92L, GLN102L, GLU35I, GLU37I, GLY104L, GLY28I, GLY36I, GLY97L, ILE34I, LEU21I, LEU29I, LEU30I, LEU32I, LEU87L, LEU93L, LEU98L, LYS103L, MET27I, PHE101L, PHE31I, SER100L, THR24I, TRP20I, TYR33I, TYR96L, VAL25I, VAL88L, VAL99L
• I-M: ALA2M, ALA6I, ALA7I, ASP5M, GLN7M, LEU10I, LEU12M, LEU16M, LEU29I, LEU3M, LYS31M, PHE14I, PHE23M, PHE9I, PRO11I, SER4I, SER8I, THR4M, THR6M, TYR30M, TYR33I, TYR5I, TYR9M, VAL8M