3P9D

the crystal structure of yeast cct reveals intrinsic asymmetry of eukaryotic cytosolic chaperonins

• Total interactions analyzed: 120
• Total true interactions: 53
• Strongest Interaction:
  • Chains: A-E
  • Int. Res.: 249
  • Norm. En. per Res.: -2.1841
• Hub Node: A(8)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-D	0.0	0.0	-0.4077	-0.4077	11	0	0	118	0	3	6
A-E	-58.3136	24.1713	-509.703	-543.8453	249	51	16	22392	1	101	107
A-F	0.0	2.6507	-0.6551	1.9957	12	0	0	126	0	2	4
A-G	-71.4782	-73.3948	-391.206	-536.0789	247	41	18	18657	9	124	131
A-H	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	2	0
A-J	-7.1138	7.5313	16.0543	16.4718	25	8	0	509	0	12	18
A-K	-4.7146	-9.4096	-81.51	-95.6343	71	7	0	4025	1	29	35
A-N	0.0	0.0	-12.3976	-12.3976	13	0	0	767	0	0	0
B-C	-58.3604	5.3245	-372.701	-425.7369	249	58	20	20470	3	126	115
B-E	0.0	0.0	-0.4578	-0.4578	7	0	0	115	0	2	13
B-F	-130.1008	26.5743	-431.024	-534.5505	280	82	17	22897	0	108	102
B-H	0.0	0.0	-1.0098	-1.0098	12	0	0	207	0	0	1
B-I	0.0	7.0498	6.7053	13.7551	25	8	0	536	0	12	17
B-M	0.0	38.7986	-65.1446	-26.346	98	3	2	4170	0	50	42
B-N	0.0	0.0	-0.001	-0.001	2	0	0	3	0	0	3
C-D	0.0	0.0	-0.6377	-0.6377	10	0	0	124	0	0	2
C-F	0.0	0.0	-9.8235	-9.8235	9	4	0	361	0	0	0
C-H	-71.9196	36.4971	-359.182	-394.6046	244	43	14	19391	1	105	104
C-I	-11.0098	-12.4566	-73.0321	-96.4985	72	7	0	3896	1	31	34
C-M	0.0	0.0	-0.0217	-0.0217	4	0	0	4	0	2	2
C-O	0.0	0.0	-0.0976	-0.0976	6	0	0	32	0	3	4
D-G	-88.8202	-59.9343	-368.486	-517.2405	265	80	26	22610	6	97	108
D-H	-85.3422	14.4328	-322.992	-393.9014	212	46	7	16388	0	61	62
D-L	0.0	0.0	-32.9204	-32.9204	67	0	0	2690	0	32	28
E-F	-56.9619	10.8903	-442.947	-489.0185	259	39	11	21476	1	146	143
E-G	0.0	0.0	-0.5643	-0.5643	6	0	0	85	0	4	7
E-J	0.0	40.8223	-68.9784	-28.1561	100	3	2	4349	0	51	42
E-K	0.0	0.0	-0.0216	-0.0216	4	0	0	4	0	1	1
E-N	-9.7319	-14.0753	-81.9506	-105.7578	51	21	0	3903	1	27	38
F-I	0.0	0.0	-10.9276	-10.9276	13	0	0	724	0	0	0
F-J	0.0	0.0	-0.0004	-0.0004	2	0	0	1	0	0	3
F-M	-11.8749	-15.3744	-54.9817	-82.231	50	29	0	4133	1	27	38
F-N	0.0	22.5975	-45.3529	-22.7554	62	0	0	2736	0	28	34
G-H	0.0	0.0	-0.1016	-0.1016	10	0	0	61	0	4	4
G-K	0.0	0.0	-0.1021	-0.1021	6	0	0	30	0	5	3
G-L	0.0	0.0	-1.0588	-1.0588	6	0	0	75	0	0	0
G-P	-27.6031	3.7102			5
H-I	0.0	0.0	-2.4146	-2.4146	8	0	0	214	0	9	6
H-L	0.0	0.0	126.722	126.722	39	16	1	2343	0	2	5
H-O	-27.4492	3.5966	-34.8315	-58.6841	56	7	0	1972	0	16	25
I-L	0.0	0.0	-0.5979	-0.5979	11	0	0	143	0	3	7
I-M	-40.3831	23.3127	-515.866	-532.9364	251	56	17	22711	1	102	107
I-N	0.0	2.5258	-0.579	1.9468	11	0	0	113	0	2	4
I-O	-78.1122	-77.2719	-113.148	-268.5321	130	11	2	5707	5	50	46
J-K	-57.2926	9.9328	-403.256	-450.6158	248	59	21	20880	3	129	117
J-M	0.0	0.0	-0.3547	-0.3547	7	0	0	105	0	2	12
J-N	-149.5157	26.4191	-435.285	-558.3815	278	81	18	23190	0	107	101
K-L	0.0	0.0	-0.1881	-0.1881	7	0	0	47	0	0	1
K-N	0.0	0.0	-16.6465	-16.6465	9	8	0	430	0	0	1
K-P	-60.5399	25.9807			21
L-O	-83.8857	-56.1261	-97.9034	-237.9152	140	62	14	10238	1	29	30
L-P	-41.5271	13.6924			13
M-N	-67.913	8.5962	-433.493	-492.8098	263	43	11	21161	1	143	144

Interface residues

• A-D: ASN250D, ASN251D, ASN263A, ASP265A, GLU249D, ILE253D, ILE262A, ILE264A, LEU270A, PRO246D, THR248D
• A-E: ALA101E, ALA254A, ALA257A, ALA331E, ALA419E, ALA422E, ALA534A, ALA537A, ALA53E, ALA54E, ALA79A, ALA87A, ARG130A, ARG255A, ARG26A, ARG274A, ARG276A, ARG327A, ARG409E, ARG443A, ARG540A, ARG55E, ARG68E, ARG92A, ARG9A, ASN263A, ASN29A, ASN332E, ASN338E, ASN343A, ASN412E, ASN486E, ASN85E, ASN98E, ASP11A, ASP196E, ASP236E, ASP248A, ASP265A, ASP266A, ASP288E, ASP304E, ASP311E, ASP329E, ASP390E, ASP542A, ASP548A, ASP71E, ASP78E, ASP91A, ASP97E, CYS514E, GLN253E, GLN261A, GLN269A, GLN272A, GLN296E, GLN299E, GLN303E, GLN337E, GLN383E, GLN88A, GLN89A, GLN90A, GLN93E, GLU18A, GLU195A, GLU262E, GLU268A, GLU271A, GLU277A, GLU283A, GLU293E, GLU294E, GLU302E, GLU308E, GLU324A, GLU330E, GLU345A, GLU347A, GLU382E, GLU384E, GLU414A, GLU418E, GLU485E, GLU533A, GLU550A, GLU80E, GLU85A, GLU93A, GLU95E, GLU99E, GLY16A, GLY17A, GLY189E, GLY22A, GLY231E, GLY232E, GLY259A, GLY263E, GLY346A, GLY386E, GLY410E, GLY488E, GLY66E, GLY69E, GLY79E, HIS121A, HIS197E, HIS285E, HIS333E, HIS77A, ILE120A, ILE125A, ILE126A, ILE192E, ILE20A, ILE234E, ILE25A, ILE262A, ILE264A, ILE273A, ILE280A, ILE289E, ILE310E, ILE380E, ILE415E, ILE522A, ILE538A, ILE541A, ILE545A, ILE60E, ILE61E, ILE73E, ILE75E, ILE81E, ILE82A, ILE83E, ILE90E, ILE94A, LEU13A, LEU15A, LEU188E, LEU270A, LEU287E, LEU298E, LEU334E, LEU336E, LEU337A, LEU344A, LEU515E, LEU52E, LEU532A, LEU539A, LEU70E, LEU74E, LEU83A, LEU86A, LEU91E, LEU96E, LYS102E, LYS191E, LYS193A, LYS195E, LYS197A, LYS19A, LYS201A, LYS261E, LYS286E, LYS305E, LYS307E, LYS314E, LYS323A, LYS389E, LYS413E, LYS526A, LYS529A, LYS72E, LYS81A, MET254E, MET256A, MET258A, MET341A, MET414E, MET544A, MET94E, PHE14A, PHE385E, PRO122A, PRO252E, PRO255E, PRO267A, PRO278E, PRO549A, PRO551A, PRO67E, PRO77E, PRO78A, SER10A, SER190E, SER192A, SER194E, SER21A, SER233E, SER235E, SER290E, SER291E, SER339A, SER340A, SER342A, SER411E, SER487E, SER49E, SER530A, SER56E, SER59E, SER64E, SER76E, SER92E, THR123A, THR124A, THR127A, THR12A, THR300E, THR336A, THR349A, THR387E, THR388E, THR543A, THR546A, THR63E, THR82E, THR84E, TYR295E, TYR301E, TYR354A, TYR381E, VAL105E, VAL116A, VAL131A, VAL193E, VAL200A, VAL230E, VAL260A, VAL292E, VAL338A, VAL536A, VAL547A, VAL57E
• A-F: ALA256F, ASP257F, HIS557A, LEU541F, LYS542F, PRO556A, SER255F, SER539F, THR540F, THR544F, TYR253F, VAL260A
• A-G: ALA105G, ALA171A, ALA19G, ALA208A, ALA213A, ALA229A, ALA232A, ALA252G, ALA254A, ALA257A, ALA257G, ALA269G, ALA273G, ALA278A, ALA320G, ALA364A, ALA390A, ALA466A, ALA467A, ALA510G, ALA513G, ALA79G, ALA80G, ALA89G, ALA92G, ARG130G, ARG191G, ARG255A, ARG260G, ARG274A, ARG325G, ARG388A, ARG506A, ARG88G, ASN245G, ASN256G, ASN263A, ASN29G, ASN324G, ASN391A, ASN465A, ASN505G, ASN508G, ASN515G, ASN526G, ASN64A, ASP172A, ASP18G, ASP193G, ASP195G, ASP255G, ASP265A, ASP266A, ASP266G, ASP272G, ASP303A, ASP304A, ASP321G, ASP340G, ASP368A, ASP369A, ASP392A, ASP50A, ASP521G, ASP55A, ASP56A, ASP59A, ASP74A, ASP74G, ASP85G, ASP91G, CYS306A, GLN21G, GLN231A, GLN261A, GLN269A, GLN272A, GLN276G, GLN335G, GLN363A, GLN76A, GLN88A, GLN90G, GLU117G, GLU215A, GLU253G, GLU258G, GLU262G, GLU265G, GLU268A, GLU271A, GLU274G, GLU277A, GLU280G, GLU309A, GLU312A, GLU344G, GLU370A, GLU397A, GLU512G, GLU522G, GLU530G, GLU93G, GLY119G, GLY128G, GLY16G, GLY170A, GLY210A, GLY22G, GLY259A, GLY279A, GLY332G, GLY389A, GLY48A, GLY528G, GLY58A, HIS123G, HIS209A, HIS263G, HIS345G, HIS77G, ILE120G, ILE125G, ILE168A, ILE169A, ILE262A, ILE264A, ILE26G, ILE270G, ILE273A, ILE327G, ILE334G, ILE504G, ILE505A, ILE517G, ILE524G, ILE57A, ILE69A, ILE86G, LEU116G, LEU124G, LEU198G, LEU250G, LEU270A, LEU277G, LEU282A, LEU305A, LEU307A, LEU395A, LEU49A, LEU501G, LEU504A, LEU516G, LEU518G, LEU53A, LEU70A, LEU72A, LEU73A, LEU83G, LYS127G, LYS131G, LYS167A, LYS197G, LYS211A, LYS235A, LYS23G, LYS251G, LYS253A, LYS254G, LYS275A, LYS308A, LYS342G, LYS365A, LYS401G, LYS468A, LYS51A, LYS527G, LYS81G, MET126G, MET233A, MET256A, MET258A, MET323G, MET398A, MET398G, MET52A, PHE175A, PHE176A, PHE366A, PHE60A, PRO267A, PRO46A, PRO78G, SER121G, SER122G, SER134G, SER166A, SER173A, SER20G, SER212A, SER230A, SER333G, SER336G, SER339G, SER367A, SER394A, SER42A, SER43A, SER509G, SER519G, SER529G, SER71A, SER87G, THR17G, THR214A, THR337G, THR511G, THR514G, THR523G, THR525G, THR61A, THR63A, THR68A, THR82G, TYR129G, TYR393A, VAL101G, VAL133G, VAL137G, VAL246G, VAL259G, VAL260A, VAL261G, VAL264G, VAL311A, VAL39A, VAL40A, VAL47A, VAL520G, VAL54A, VAL62A, VAL75A, VAL75G, VAL76G, VAL84A, VAL84G, VAL94G
• A-H: ASN263A, LEU266H
• A-J: ALA15J, ALA18J, ALA22J, ARG14J, ARG19J, ARG9A, ASN17J, ASN71J, ASP11A, ASP23A, ASP24A, GLU12J, GLU13J, GLU16J, GLY22A, GLY25J, LEU20J, PRO72J, SER10A, SER21A, SER21J, SER8A, THR11J, THR543A, VAL24J
• A-K: ALA463A, ALA466A, ALA467A, ALA475A, ARG18K, ARG443A, ARG454K, ARG466K, ARG472K, ASN113A, ASN115K, ASN118A, ASN27A, ASN38A, ASN459K, ASN465A, ASP23A, ASP33K, ASP463K, ASP469A, GLN106K, GLN458K, GLU107A, GLU113K, GLU114A, GLU472A, GLY436K, GLY461K, GLY462K, HIS117K, ILE112K, ILE116K, ILE120A, ILE120K, ILE22K, ILE437K, ILE457A, ILE457K, ILE465K, LEU111K, LEU115A, LEU31A, LEU446A, LEU456A, LEU456K, LEU468K, LEU473A, LYS114K, LYS117A, LYS119A, LYS29K, LYS460A, LYS468A, MET34A, PRO109K, PRO459A, PRO464K, SER42A, SER442A, SER469K, SER470A, SER471A, THR26K, THR37K, THR455K, THR461A, TYR110K, VAL116A, VAL30A, VAL464A, VAL474A
• A-N: ARG9A, ASP11A, GLN4N, LEU13A, LEU15A, LEU3N, LEU5N, MET1N, PHE14A, SER10A, SER2N, SER8A, THR12A
• B-C: ALA129B, ALA15B, ALA256B, ALA259B, ALA27C, ALA28C, ALA305C, ALA309B, ALA30C, ALA318B, ALA43C, ALA460C, ALA496B, ALA501B, ALA504B, ALA505B, ALA517B, ALA71C, ALA73B, ALA74B, ALA74C, ALA75C, ARG125B, ARG14B, ARG19B, ARG236C, ARG271C, ARG287B, ARG316B, ARG382C, ARG495B, ARG510B, ARG516B, ARG518B, ARG66C, ASN189B, ASN235B, ASN260C, ASN270C, ASN286B, ASN390C, ASN459C, ASN513B, ASN59C, ASN71B, ASN79B, ASP213C, ASP216C, ASP241B, ASP253B, ASP268C, ASP303C, ASP310B, ASP330B, ASP33C, ASP362C, ASP387C, ASP50C, ASP512B, ASP69C, ASP70B, ASP85B, ASP86B, CYS335B, CYS38C, GLN118B, GLN258C, GLN260B, GLN274C, GLN279C, GLN281C, GLN306C, GLN458C, GLN4B, GLN84B, GLU122B, GLU12B, GLU13B, GLU191B, GLU251C, GLU262C, GLU264C, GLU266C, GLU267B, GLU267C, GLU276C, GLU277C, GLU315B, GLU324B, GLU358C, GLU363C, GLU391C, GLU503B, GLU506B, GLU67C, GLU87B, GLY123B, GLY211C, GLY212C, GLY247B, GLY255C, GLY313B, GLY322B, GLY323B, GLY361C, GLY383C, GLY384C, GLY40C, GLY461C, GLY53C, GLY54C, GLY7B, HIS116B, HIS166C, HIS192B, HIS231C, HIS237C, HIS307C, HIS308B, HIS72C, ILE121B, ILE165C, ILE209C, ILE233B, ILE245B, ILE261C, ILE263C, ILE272C, ILE275C, ILE35C, ILE360C, ILE388C, ILE392C, ILE514B, ILE515B, ILE5B, ILE64C, ILE68C, ILE80B, LEU126B, LEU132B, LEU190B, LEU215C, LEU258B, LEU273C, LEU304C, LEU310C, LEU317B, LEU319B, LEU389C, LEU45C, LEU48C, LEU49C, LEU508B, LEU509B, LEU55C, LEU57C, LEU69B, LEU77B, LYS162C, LYS185B, LYS233C, LYS242B, LYS244B, LYS249B, LYS251B, LYS253C, LYS254C, LYS257B, LYS263B, LYS265C, LYS311C, LYS386C, LYS42C, LYS46C, LYS492B, LYS75B, LYS76C, LYS82B, MET234C, MET359C, MET44C, MET47C, MET52C, PHE246B, PHE250B, PHE311B, PHE329B, PHE365C, PHE6B, PRO117B, PRO210C, PRO232C, PRO41C, PRO51C, PRO72B, PRO73C, SER187B, SER23C, SER302C, SER327B, SER385C, SER499B, SER500B, SER502B, SER81B, THR119B, THR11B, THR161C, THR188B, THR236B, THR240B, THR248B, THR255B, THR259C, THR321B, THR37C, THR58C, TRP167C, TRP269C, TYR124B, TYR163C, TYR252C, TYR308C, TYR364C, VAL10B, VAL164C, VAL214C, VAL229C, VAL230C, VAL243B, VAL252B, VAL280C, VAL314B, VAL31C, VAL320B, VAL325B, VAL326B, VAL34C, VAL357C, VAL3B, VAL507B, VAL511B, VAL56C, VAL70C, VAL76B, VAL78B, VAL83B, VAL88B
• B-E: LYS249B, LYS251B, LYS284E, LYS286E, PHE250B, THR248B, THR283E
• B-F: ALA10F, ALA184F, ALA186F, ALA18F, ALA263F, ALA264B, ALA264F, ALA26B, ALA272F, ALA28B, ALA336F, ALA372B, ALA448B, ALA49B, ALA520F, ALA524F, ALA536F, ALA73B, ALA73F, ALA74B, ALA77F, ALA79F, ALA80F, ALA81F, ALA82F, ARG116F, ARG126F, ARG14F, ARG15F, ARG259F, ARG322F, ARG323F, ARG370B, ARG400F, ARG511F, ARG514F, ARG535F, ARG538F, ARG78F, ASN188F, ASN220B, ASN221B, ASN22F, ASN237F, ASN248F, ASN338F, ASN404F, ASN447B, ASN475B, ASN515F, ASN526F, ASN52B, ASN58B, ASN71B, ASN7F, ASP120F, ASP187F, ASP190F, ASP205B, ASP239B, ASP241B, ASP253B, ASP260F, ASP292B, ASP300B, ASP31B, ASP342F, ASP374B, ASP43B, ASP446B, ASP531F, ASP70B, ASP84F, CYS530F, CYS54B, GLN168B, GLN185F, GLN222B, GLN258F, GLN260B, GLN296B, GLN298F, GLN329F, GLN337F, GLN346F, GLN351B, GLN375B, GLN47B, GLN4F, GLN69F, GLN83F, GLU11F, GLU123F, GLU246F, GLU262B, GLU265B, GLU266F, GLU267B, GLU295B, GLU326F, GLU335F, GLU341F, GLU344B, GLU345B, GLU350B, GLU379B, GLU532F, GLU85F, GLY121F, GLY200B, GLY201B, GLY219B, GLY247B, GLY250F, GLY25B, GLY333F, GLY334F, GLY349B, GLY371B, GLY38B, GLY41B, GLY449B, GLY519F, GLY522F, GLY537F, HIS114F, HIS192F, ILE117F, ILE118F, ILE124F, ILE165B, ILE198B, ILE235F, ILE27B, ILE290B, ILE343B, ILE346B, ILE347F, ILE517F, ILE523F, ILE63B, ILE67B, ILE68F, ILE76F, ILE86F, LEU13F, LEU166B, LEU189F, LEU191F, LEU199B, LEU19F, LEU203B, LEU238B, LEU258B, LEU261B, LEU262F, LEU297B, LEU301B, LEU32B, LEU330F, LEU343F, LEU348B, LEU369B, LEU377B, LEU37B, LEU3F, LEU45B, LEU46B, LEU527F, LEU528F, LEU529F, LEU533F, LEU534F, LEU5F, LEU64B, LEU69B, LEU6F, LEU75F, LYS127F, LYS164B, LYS170B, LYS202B, LYS217B, LYS224B, LYS242B, LYS244B, LYS244F, LYS249B, LYS251B, LYS257B, LYS261F, LYS263B, LYS268B, LYS268F, LYS34B, LYS407F, LYS40B, LYS44B, LYS75B, LYS9F, MET193F, MET269B, MET325F, MET347B, MET42B, MET55B, PHE122F, PHE246B, PHE250B, PHE251F, PHE252F, PHE269F, PHE298B, PRO115F, PRO223B, PRO294B, PRO345F, PRO352B, PRO39B, PRO68B, PRO71F, PRO72B, PRO8F, SER12F, SER162B, SER163B, SER167B, SER204B, SER21B, SER239F, SER249F, SER254B, SER254F, SER255F, SER265F, SER2F, SER339F, SER344F, SER35B, SER48B, SER50B, SER51B, SER525F, SER539F, SER66B, SER70F, THR119F, THR240B, THR245F, THR248B, THR255B, THR299B, THR36B, THR373B, THR376B, THR440F, THR518F, THR521F, THR53B, THR57B, THR72F, THR87F, TYR253F, TYR291B, TYR293B, VAL113F, VAL21F, VAL238F, VAL243B, VAL247F, VAL24B, VAL252B, VAL29B, VAL33B, VAL340F, VAL56B, VAL74F, VAL78B, VAL94F, VAL98F
• B-H: ALA270H, GLY247B, ILE245B, LEU266H, LEU267H, MET273H, PHE246B, PHE276H, SER277H, THR248B, VAL243B, VAL265H
• B-I: ALA15B, ALA18B, ALA22B, ARG14B, ARG19B, ARG9I, ASN17B, ASN71B, ASP11I, ASP23I, ASP24I, GLU12B, GLU13B, GLU16B, GLY22I, GLY25B, LEU20B, PRO72B, SER10I, SER21B, SER21I, SER8I, THR11B, THR543I, VAL24B
• B-M: ALA28B, ALA429B, ALA448B, ARG104B, ARG435B, ARG438B, ARG55M, ASN17B, ASN37M, ASN447B, ASN475B, ASN476B, ASP111B, ASP131M, ASP31B, ASP34M, ASP423B, ASP446B, ASP451B, ASP473B, ASP477M, ASP490M, GLN132M, GLN138M, GLN35M, GLN41M, GLN439B, GLN466M, GLN474M, GLU107B, GLU135M, GLU16B, GLU454B, GLU45M, GLU485M, GLY140M, GLY36M, GLY424B, GLY449B, GLY463M, GLY477B, GLY493M, HIS116B, ILE110B, ILE115B, ILE137M, ILE141M, ILE27B, ILE31M, ILE443B, ILE464M, ILE492M, ILE51M, ILE60M, LEU109B, LEU134M, LEU136M, LEU20B, LEU32B, LEU428B, LEU44M, LEU455B, LEU474B, LEU495M, LEU52M, LYS108B, LYS139M, LYS33M, LYS38M, LYS40B, LYS425B, LYS426B, LYS458B, LYS48M, MET42B, MET481M, PHE23B, PHE450B, PRO39B, PRO491M, SER21B, SER35B, SER427B, SER452B, SER453B, SER457B, SER496M, SER56M, SER59M, THR442B, THR478B, THR478M, THR482M, THR63M, TYR467M, VAL24B, VAL32M, VAL456B
• B-N: ASP451B, LEU467N
• C-D: ASN260C, GLN258C, GLU256C, GLU262C, ILE252D, ILE253D, MET260D, SER257C, THR259C, VAL254D
• C-F: ASN248F, GLU246F, GLY250F, ILE263C, PHE252F, SER249F, THR245F, TRP269C, VAL247F
• C-H: ALA10C, ALA20C, ALA270H, ALA309H, ALA329C, ALA334C, ALA34H, ALA389H, ALA467H, ALA513C, ALA71C, ALA74C, ALA75C, ARG202C, ARG271C, ARG315H, ARG327C, ARG330C, ARG339C, ARG367H, ARG387H, ARG51H, ARG522C, ARG531C, ARG83C, ASN115C, ASN219H, ASN24C, ASN258H, ASN260C, ASN269H, ASN270C, ASN314H, ASN325C, ASN326C, ASN338C, ASN392H, ASN393H, ASN52H, ASN57H, ASN66H, ASN9C, ASP199C, ASP247C, ASP255H, ASP268C, ASP275H, ASP285H, ASP342C, ASP347C, ASP366H, ASP395H, ASP396H, ASP493H, ASP524C, ASP525C, ASP76H, ASP86C, CYS49H, CYS518C, GLN123C, GLN12C, GLN258C, GLN271H, GLN274C, GLN279C, GLN281C, GLN286C, GLN391H, GLN397C, GLN40H, GLN507C, GLN508C, GLN85C, GLU13C, GLU231H, GLU256C, GLU262C, GLU264C, GLU267C, GLU272H, GLU276C, GLU277C, GLU278C, GLU280H, GLU281H, GLU298C, GLU307H, GLU341C, GLU362H, GLU37H, GLU465H, GLU515C, GLU74H, GLU80C, GLU87C, GLU88C, GLY173H, GLY214H, GLY215H, GLY234H, GLY255C, GLY263H, GLY279H, GLY364H, GLY365H, GLY388H, GLY468H, GLY47H, GLY50H, GLY529C, GLY60H, HIS117C, HIS235H, HIS268H, HIS311H, HIS494H, HIS58H, HIS72C, HIS79H, ILE116C, ILE120C, ILE122C, ILE198C, ILE200C, ILE212H, ILE256H, ILE261C, ILE263C, ILE272C, ILE275C, ILE284H, ILE336C, ILE35H, ILE363H, ILE397H, ILE514C, ILE526C, ILE54H, ILE55H, ILE62H, ILE63H, ILE64H, ILE77H, LEU129C, LEU133C, LEU178H, LEU217H, LEU245C, LEU266H, LEU267H, LEU273C, LEU274H, LEU282C, LEU308H, LEU310H, LEU343C, LEU38H, LEU394H, LEU469H, LEU519C, LEU520C, LEU521C, LEU59H, LEU75H, LEU79C, LEU81C, LYS126C, LYS170H, LYS171H, LYS201C, LYS237H, LYS265C, LYS278H, LYS282H, LYS30H, LYS322C, LYS344C, LYS359H, LYS511C, LYS53H, LYS61H, LYS76C, LYS83H, MET213H, MET273H, MET283C, MET361H, MET41H, MET71H, MET78C, MET8C, PHE276H, PHE7C, PRO118C, PRO48H, PRO73C, PRO80H, SER174H, SER216H, SER218H, SER238H, SER257C, SER277H, SER31H, SER45H, SER509C, SER516C, SER528C, SER77C, SER82C, THR130C, THR16C, THR259C, THR259H, THR264H, THR335C, THR360H, THR390H, THR44H, THR466H, THR512C, THR65H, THR84C, TRP269C, TYR172H, TYR312H, VAL119C, VAL236H, VAL265H, VAL280C, VAL337C, VAL340C, VAL504C, VAL510C, VAL523C, VAL527C, VAL530C, VAL56H, VAL6C, VAL78H, VAL82H, VAL89C, VAL96C
• C-I: ALA463I, ALA466I, ALA467I, ALA475I, ARG18C, ARG443I, ARG454C, ARG466C, ARG472C, ASN113I, ASN115C, ASN118I, ASN27I, ASN38I, ASN459C, ASN465I, ASP23I, ASP33C, ASP463C, ASP469I, GLN106C, GLN458C, GLU107I, GLU113C, GLU114I, GLU472I, GLY436C, GLY461C, GLY462C, HIS117C, ILE112C, ILE116C, ILE120C, ILE120I, ILE22C, ILE437C, ILE457C, ILE457I, ILE465C, LEU111C, LEU115I, LEU31I, LEU446I, LEU456C, LEU456I, LEU468C, LEU473I, LYS110I, LYS114C, LYS117I, LYS119I, LYS29C, LYS41I, LYS460I, LYS468I, MET34I, PRO109C, PRO459I, PRO464C, SER42I, SER442I, SER469C, SER470I, SER471I, THR26C, THR37C, THR455C, THR461I, TYR110C, VAL30I, VAL464I, VAL474I
• C-M: ASP490M, GLY461C, GLY462C, GLY488M
• C-O: ARG18C, GLN21O, GLY17C, GLY22O, GLY24O, THR16C
• D-G: ALA121D, ALA128D, ALA175G, ALA208G, ALA227G, ALA23D, ALA252G, ALA257G, ALA269D, ALA269G, ALA303G, ALA308G, ALA32G, ALA334D, ALA35G, ALA382G, ALA387G, ALA39G, ALA457G, ALA507D, ALA511D, ALA525D, ALA75D, ALA80G, ALA83D, ALA84D, ALA89D, ALA9D, ARG258D, ARG260G, ARG268D, ARG310G, ARG318D, ARG343D, ARG361G, ARG379G, ARG520D, ARG528D, ARG76D, ASN13D, ASN173G, ASN174G, ASN185D, ASN188D, ASN192D, ASN24D, ASN250D, ASN251D, ASN255D, ASN256G, ASN273D, ASN31G, ASN456G, ASN57G, ASN64G, ASN8D, ASP122D, ASP176G, ASP190D, ASP193D, ASP247D, ASP255G, ASP261D, ASP266G, ASP272G, ASP301G, ASP309G, ASP335D, ASP50G, ASP522D, ASP523D, ASP74G, ASP86D, CYS330D, CYS33G, CYS399D, CYS514D, GLN125D, GLN231G, GLN238D, GLN259D, GLN268G, GLN289D, GLN305G, GLN356G, GLN37G, GLN384G, GLN58G, GLN85D, GLU15D, GLU210G, GLU211G, GLU230G, GLU249D, GLU249G, GLU253G, GLU258G, GLU262G, GLU265G, GLU266D, GLU267D, GLU274G, GLU319D, GLU322D, GLU337D, GLU354G, GLU360G, GLU383G, GLU388G, GLU38G, GLU513D, GLU80D, GLU88D, GLY206G, GLY207G, GLY228G, GLY300G, GLY329D, GLY358G, GLY380G, GLY381G, GLY458G, GLY48G, GLY90D, HIS116D, HIS172G, HIS263G, HIS395D, HIS72D, HIS77G, ILE119D, ILE194D, ILE204G, ILE237D, ILE252D, ILE253D, ILE263D, ILE270G, ILE274D, ILE299G, ILE321D, ILE333D, ILE336D, ILE357G, ILE386G, ILE518D, ILE51G, ILE521D, ILE524D, ILE53G, ILE62G, ILE69G, ILE70D, LEU170G, LEU191D, LEU236D, LEU250G, LEU264D, LEU271D, LEU272D, LEU302G, LEU324D, LEU338D, LEU47G, LEU502D, LEU510D, LEU519D, LEU52G, LEU70G, LEU71D, LEU72G, LEU73G, LEU78D, LYS129D, LYS12D, LYS14D, LYS169G, LYS234G, LYS245D, LYS251G, LYS262D, LYS265D, LYS290D, LYS326D, LYS331D, LYS41G, LYS516D, LYS59G, LYS71G, LYS81G, MET209G, MET355G, MET77D, PHE11D, PHE124D, PHE178G, PHE224G, PHE229G, PHE239D, PHE279G, PHE306G, PHE307G, PHE323D, PHE339D, PHE526D, PRO117D, PRO17D, PRO205G, PRO243D, PRO244D, PRO246D, PRO332D, PRO42G, PRO46G, PRO73D, SER126D, SER325D, SER359G, SER49G, SER506D, SER512D, SER517D, SER527D, SER56G, SER63G, SER7D, SER82D, SER87D, THR10D, THR118D, THR223G, THR248D, THR304G, THR43G, THR505D, THR509D, THR55G, THR60G, THR61G, TRP275G, TYR226G, TYR267G, TYR270D, VAL132D, VAL189D, VAL20D, VAL254D, VAL259G, VAL261G, VAL264G, VAL271G, VAL34G, VAL36G, VAL385G, VAL389G, VAL503D, VAL515D, VAL54G, VAL74D, VAL75G, VAL76G, VAL79D, VAL81D, VAL84G, VAL96D
• D-H: ALA124H, ALA223D, ALA24H, ALA257H, ALA27D, ALA286H, ALA296D, ALA301D, ALA338H, ALA346H, ALA34D, ALA382D, ALA522H, ALA527H, ALA531H, ALA534H, ALA535H, ALA69D, ALA75D, ALA81H, ALA88H, ARG135H, ARG258D, ARG268D, ARG330H, ARG331H, ARG334H, ARG343H, ARG380H, ARG52D, ARG76D, ASN132H, ASN19H, ASN203H, ASN250D, ASN251D, ASN255D, ASN258H, ASN298D, ASN383D, ASN384D, ASN529H, ASN59D, ASP205D, ASP205H, ASP256D, ASP25H, ASP261D, ASP275H, ASP295D, ASP299D, ASP33D, ASP354D, ASP356D, ASP45D, ASP519H, ASP95H, CYS252H, CYS333H, GLN129H, GLN165D, GLN16H, GLN259D, GLN27H, GLN283H, GLN67D, GLN91H, GLN92H, GLU249D, GLU260H, GLU266D, GLU267D, GLU272H, GLU280H, GLU281H, GLU351H, GLU389D, GLU515H, GLU533H, GLU54D, GLU90H, GLY12H, GLY17H, GLY201D, GLY202D, GLY224D, GLY263H, GLY279H, GLY345H, GLY357D, GLY381D, GLY43D, GLY53D, HIS268H, HIS303D, HIS72D, HIS79H, ILE128H, ILE162D, ILE204D, ILE220D, ILE252D, ILE253D, ILE256H, ILE263D, ILE26D, ILE284H, ILE28H, ILE35H, ILE386D, ILE48D, ILE528H, ILE55D, ILE56D, ILE57D, ILE64D, ILE70D, ILE77H, ILE94H, LEU13H, LEU264D, LEU266H, LEU267H, LEU271D, LEU300D, LEU302D, LEU329H, LEU341H, LEU344H, LEU65D, LEU71D, LEU85H, LYS15H, LYS221D, LYS245D, LYS262D, LYS262H, LYS265D, LYS278H, LYS282H, LYS307D, LYS326H, LYS42D, LYS46D, LYS49D, LYS525H, LYS83H, MET260D, MET273H, MET287H, MET385D, MET44D, MET47D, MET68D, MET87H, PHE14H, PHE276H, PHE304D, PHE526H, PRO243D, PRO244D, PRO246D, PRO340H, PRO342H, PRO73D, PRO80H, SER123H, SER164D, SER20H, SER222D, SER22H, SER277H, SER30D, SER31H, SER355D, SER51D, SER58D, THR203D, THR227D, THR251H, THR259H, THR261H, THR264H, THR339H, THR37D, THR390D, THR50D, THR523H, THR532H, THR536H, THR537H, TYR166D, TYR18H, TYR201H, TYR21H, TYR257D, TYR270D, TYR518H, VAL125H, VAL163D, VAL200D, VAL204H, VAL254D, VAL265H, VAL297D, VAL31D, VAL530H, VAL538H, VAL78H, VAL79D, VAL82H, VAL84H
• D-L: ALA102D, ALA102L, ALA106D, ALA106L, ALA446D, ALA446L, ARG109D, ARG109L, ARG29D, ARG29L, ARG36D, ARG36L, ASN112D, ASN112L, ASN461D, ASN461L, ASP33D, ASP33L, GLN18D, GLN18L, GLU448D, GLU448L, GLU456D, GLU456L, GLY105D, GLY105L, GLY114D, GLY114L, HIS116D, HIS116L, ILE115D, ILE115L, ILE119D, ILE119L, ILE26D, ILE26L, ILE439D, ILE439L, ILE463D, ILE463L, LEU110D, LEU110L, LEU111D, LEU111L, LYS113D, LYS113L, LYS22D, LYS22L, LYS464D, LYS464L, PHE438L, SER30D, SER30L, SER445D, SER445L, SER462D, SER462L, THR452D, THR452L, THR453D, THR453L, VAL435D, VAL435L, VAL449D, VAL449L, VAL466D, VAL466L
• E-F: ALA101E, ALA147E, ALA154E, ALA256F, ALA263F, ALA264F, ALA310F, ALA355E, ALA387F, ALA389F, ALA471F, ALA50F, ALA541E, ARG103F, ARG220F, ARG259F, ARG267F, ARG361E, ARG365E, ARG40E, ARG431E, ARG546E, ASN148E, ASN248F, ASN359E, ASN37E, ASN432E, ASN461F, ASN494F, ASN52F, ASN553E, ASN98E, ASP112E, ASP113E, ASP151E, ASP165F, ASP206F, ASP218E, ASP220E, ASP222E, ASP223F, ASP257F, ASP260F, ASP288E, ASP302F, ASP304E, ASP307F, ASP34E, ASP368E, ASP372E, ASP436E, ASP465F, ASP48F, ASP552E, ASP97E, CYS274E, CYS545E, GLN106E, GLN111E, GLN200F, GLN258F, GLN296E, GLN299E, GLN303E, GLN324E, GLN349E, GLN35E, GLN367E, GLN390F, GLN536E, GLN537E, GLN543E, GLN67F, GLU114E, GLU241F, GLU243F, GLU266F, GLU293E, GLU294E, GLU302E, GLU308E, GLU34F, GLU350E, GLU352E, GLU357F, GLU361F, GLU362F, GLU65F, GLU99E, GLY149E, GLY219F, GLY250F, GLY348E, GLY360E, GLY360F, GLY36E, GLY382F, GLY38F, GLY41F, GLY43E, GLY463F, GLY49F, GLY51F, GLY558E, HIS142E, HIS201F, HIS221F, HIS285E, HIS312F, HIS353E, HIS385F, HIS50E, ILE100E, ILE115E, ILE144E, ILE271E, ILE289E, ILE31E, ILE354E, ILE356E, ILE359F, ILE362E, ILE532E, ILE538E, ILE53F, ILE548E, ILE551E, ILE555E, ILE556E, ILE68F, LEU103E, LEU104E, LEU107E, LEU166F, LEU202F, LEU262F, LEU287E, LEU298E, LEU306F, LEU351E, LEU369E, LEU388F, LEU43F, LEU467F, LEU46F, LEU470F, LEU539E, LEU540E, LEU544E, LEU549E, LEU55F, LEU62F, LEU63F, LEU96E, LYS102E, LYS109E, LYS145E, LYS155E, LYS161F, LYS205F, LYS244F, LYS261F, LYS268F, LYS280E, LYS282E, LYS284E, LYS286E, LYS297E, LYS305E, LYS311F, LYS363F, LYS373E, LYS381F, LYS38E, LYS39E, LYS402E, LYS40F, LYS435E, LYS44F, LYS460F, LYS47E, LYS535E, LYS54F, LYS550E, LYS559E, LYS57F, MET199F, MET304F, MET45F, MET472F, MET547E, MET66F, PHE221E, PHE251F, PHE252F, PHE306E, PHE309F, PHE366E, PHE464F, PRO143E, PRO204F, PRO222F, PRO275E, PRO278E, PRO279E, PRO281E, PRO303F, PRO364E, PRO39F, PRO466F, SER108E, SER110E, SER203F, SER249F, SER254F, SER255F, SER265F, SER290E, SER291E, SER305F, SER31F, SER357E, SER370E, SER383F, SER462F, SER557E, THR160F, THR245F, THR273E, THR283E, THR300E, THR358F, THR35F, THR384F, THR391F, THR42F, THR457F, THR542E, THR56F, THR64F, TRP325E, TYR242F, TYR253F, TYR295E, TYR301E, TYR386F, VAL105E, VAL122E, VAL162F, VAL219E, VAL247F, VAL308F, VAL32F, VAL363E, VAL469F, VAL473F, VAL47F, VAL554E, VAL61F
• E-G: ALA257G, ASP255G, GLU253G, GLU258G, ILE289E, TYR295E
• E-J: ALA28J, ALA429J, ALA448J, ARG104J, ARG435J, ARG438J, ARG55E, ASN17J, ASN37E, ASN447J, ASN475J, ASN476J, ASP111J, ASP131E, ASP31J, ASP34E, ASP423J, ASP446J, ASP451J, ASP473J, ASP477E, ASP490E, GLN132E, GLN138E, GLN35E, GLN41E, GLN439J, GLN466E, GLN474E, GLU107J, GLU135E, GLU16J, GLU454J, GLU45E, GLU485E, GLY140E, GLY36E, GLY424J, GLY449J, GLY463E, GLY477J, GLY493E, HIS116J, ILE110J, ILE115J, ILE137E, ILE141E, ILE27J, ILE31E, ILE443J, ILE464E, ILE492E, ILE51E, ILE60E, LEU109J, LEU134E, LEU136E, LEU20J, LEU32J, LEU428J, LEU44E, LEU455J, LEU474J, LEU489E, LEU495E, LEU52E, LYS108J, LYS139E, LYS33E, LYS38E, LYS40J, LYS425J, LYS426J, LYS458J, LYS48E, LYS62E, MET42J, MET481E, PHE23J, PHE450J, PRO39J, PRO491E, SER21J, SER35J, SER427J, SER452J, SER453J, SER457J, SER496E, SER56E, SER59E, THR442J, THR478E, THR478J, THR482E, THR63E, TYR467E, VAL24J, VAL32E, VAL456J
• E-K: ASP490E, GLY461K, GLY462K, GLY488E
• E-N: ALA105N, ALA17N, ALA18N, ARG107N, ARG116N, ARG14N, ARG15N, ARG40E, ASN37E, ASN98E, ASP120N, ASP16N, ASP34E, ASP531N, ASP97E, GLN110N, GLN35E, GLN41E, GLN4N, GLU111N, GLU45E, GLU532N, GLY112N, GLY121N, GLY36E, GLY438N, GLY43E, HIS106N, HIS114N, HIS42E, ILE109N, ILE117N, ILE118N, ILE124N, LEU19N, LEU44E, LEU52E, LYS33E, LYS38E, LYS39E, LYS437N, LYS439N, LYS441N, MET1N, PHE108N, PRO115N, SER49E, THR119N, THR440N, VAL113N, VAL32E
• F-I: ARG9I, ASP11I, GLN4F, LEU13I, LEU15I, LEU3F, LEU5F, MET1F, PHE14I, SER10I, SER2F, SER8I, THR12I
• F-J: ASP451J, LEU467F
• F-M: ALA105F, ALA17F, ALA18F, ARG107F, ARG116F, ARG14F, ARG15F, ARG40M, ASN37M, ASP120F, ASP16F, ASP34M, ASP531F, ASP97M, GLN110F, GLN35M, GLN41M, GLN4F, GLU111F, GLU45M, GLU532F, GLY112F, GLY121F, GLY36M, GLY438F, GLY43M, HIS106F, HIS114F, HIS42M, ILE109F, ILE117F, ILE118F, ILE124F, LEU19F, LEU44M, LEU52M, LYS33M, LYS38M, LYS39M, LYS437F, LYS439F, LYS441F, MET1F, PHE108F, PRO115F, SER49M, THR119F, THR440F, VAL113F, VAL32M
• F-N: ALA471F, ALA471N, ARG103F, ARG103N, ARG107F, ARG107N, ASN461F, ASN461N, ASP475F, ASP475N, GLN104F, GLN104N, GLN110F, GLN110N, GLU100F, GLU100N, GLU111F, GLU111N, GLU34F, GLU34N, GLU543F, GLU543N, GLY112F, GLY112N, GLY438F, GLY438N, ILE109F, ILE109N, ILE117F, ILE117N, LEU434F, LEU434N, LEU470F, LEU470N, LYS439F, LYS439N, LYS441F, LYS441N, LYS456F, LYS456N, LYS460F, LYS460N, MET472F, MET472N, PHE108F, PHE108N, THR440F, THR440N, THR442F, THR442N, THR457F, THR457N, THR544F, THR544N, VAL113F, VAL113N, VAL453F, VAL453N, VAL469F, VAL469N, VAL473F, VAL473N
• G-H: ARG260G, GLU262G, GLY263H, HIS268H, LEU266H, LYS262H, THR261H, TYR267G, VAL259G, VAL261G
• G-K: ARG18K, GLN21G, GLY17K, GLY22G, GLY24G, THR16K
• G-L: ALA458L, ASN461L, GLU456L, GLY459L, LEU460L, PHE459G
• G-P: GLN58G, GLN7P, GLU118G, GLU457P, PRO6P
• H-I: ALA467H, ALA467I, ASP469I, ASP470H, GLY468H, LEU469H, LYS468I, VAL471H
• H-L: ALA11H, ALA23L, ALA27L, ALA525L, ALA69L, ARG528L, ARG76L, ASN10H, ASN13L, ASN23H, ASN8H, GLN7H, GLU15L, GLU19L, GLY12H, GLY26H, HIS72L, ILE26L, ILE29H, ILE524L, ILE70L, LEU13H, LEU5H, LEU71L, LYS12L, LYS14L, LYS16L, LYS22L, LYS30H, PHE526L, PRO17L, PRO6H, PRO73L, PRO9H, SER527L, SER7L, TYR21H, VAL20L, VAL74L
• H-O: ALA33H, ALA35O, ARG36H, ARG461H, ASN10H, ASN112H, ASN31O, ASN472H, ASN57O, ASN8H, ASP470H, GLN37O, GLN40H, GLN58O, GLN7H, GLU107O, GLU109H, GLU111O, GLU115H, GLU117O, GLU118O, GLU37H, GLU38O, GLU457H, GLU465H, GLU473H, GLY119O, GLY24O, GLY26H, ILE120O, ILE27O, ILE29H, ILE53O, LEU124O, LEU43H, LEU475H, LEU52O, LEU5H, LYS110O, LYS116H, LYS23O, LYS30H, LYS59O, PRO114O, PRO6H, PRO9H, SER119H, SER121O, SER56O, THR55O, THR60O, THR61O, VAL113H, VAL34O, VAL471H, VAL54O
• I-L: ASN250L, ASN251L, ASN263I, ASP265I, GLU249L, ILE253L, ILE262I, ILE264I, ILE273I, LEU270I, THR248L
• I-M: ALA101M, ALA254I, ALA257I, ALA278I, ALA331M, ALA419M, ALA422M, ALA534I, ALA537I, ALA53M, ALA54M, ALA79I, ALA87I, ARG130I, ARG255I, ARG26I, ARG274I, ARG276I, ARG327I, ARG409M, ARG540I, ARG55M, ARG68M, ARG92I, ARG9I, ASN263I, ASN29I, ASN332M, ASN338M, ASN343I, ASN412M, ASN486M, ASN85M, ASN98M, ASP11I, ASP196M, ASP236M, ASP248I, ASP265I, ASP266I, ASP288M, ASP304M, ASP311M, ASP329M, ASP390M, ASP542I, ASP548I, ASP71M, ASP78M, ASP91I, ASP97M, CYS514M, GLN253M, GLN261I, GLN269I, GLN272I, GLN296M, GLN299M, GLN303M, GLN337M, GLN383M, GLN88I, GLN89I, GLN90I, GLN93M, GLU18I, GLU195I, GLU262M, GLU268I, GLU271I, GLU277I, GLU283I, GLU293M, GLU294M, GLU302M, GLU308M, GLU324I, GLU330M, GLU345I, GLU347I, GLU382M, GLU384M, GLU414I, GLU418M, GLU485M, GLU533I, GLU550I, GLU80M, GLU85I, GLU93I, GLU95M, GLU99M, GLY16I, GLY17I, GLY189M, GLY22I, GLY231M, GLY232M, GLY259I, GLY263M, GLY346I, GLY386M, GLY410M, GLY488M, GLY66M, GLY69M, GLY79M, HIS121I, HIS197M, HIS285M, HIS333M, HIS50M, HIS77I, ILE120I, ILE125I, ILE126I, ILE192M, ILE20I, ILE234M, ILE25I, ILE262I, ILE264I, ILE273I, ILE280I, ILE289M, ILE310M, ILE380M, ILE415M, ILE522I, ILE538I, ILE541I, ILE545I, ILE60M, ILE61M, ILE73M, ILE75M, ILE81M, ILE82I, ILE83M, ILE90M, ILE94I, LEU13I, LEU15I, LEU188M, LEU270I, LEU287M, LEU298M, LEU334M, LEU336M, LEU337I, LEU344I, LEU515M, LEU52M, LEU532I, LEU539I, LEU70M, LEU74M, LEU83I, LEU86I, LEU91M, LEU96M, LYS102M, LYS191M, LYS193I, LYS195M, LYS197I, LYS19I, LYS201I, LYS261M, LYS280M, LYS286M, LYS305M, LYS307M, LYS314M, LYS323I, LYS389M, LYS413M, LYS526I, LYS529I, LYS72M, LYS81I, MET254M, MET256I, MET258I, MET341I, MET414M, MET544I, MET94M, PHE14I, PHE385M, PRO122I, PRO252M, PRO255M, PRO267I, PRO278M, PRO549I, PRO551I, PRO67M, PRO77M, PRO78I, SER10I, SER190M, SER192I, SER194M, SER21I, SER233M, SER235M, SER290M, SER291M, SER339I, SER340I, SER342I, SER411M, SER487M, SER49M, SER530I, SER56M, SER59M, SER64M, SER76M, SER92M, THR123I, THR124I, THR127I, THR12I, THR300M, THR336I, THR349I, THR387M, THR388M, THR543I, THR546I, THR63M, THR82M, THR84M, TYR295M, TYR301M, TYR354I, TYR381M, VAL105M, VAL116I, VAL131I, VAL193M, VAL200I, VAL230M, VAL260I, VAL292M, VAL338I, VAL536I, VAL547I, VAL57M
• I-N: ALA256N, ASP257N, HIS557I, LYS542N, PRO556I, SER255N, SER539N, THR540N, THR544N, TYR253N, VAL260I
• I-O: ALA105O, ALA171I, ALA19O, ALA208I, ALA213I, ALA232I, ALA364I, ALA390I, ALA466I, ALA467I, ALA79O, ALA80O, ALA89O, ALA92O, ARG130O, ARG191O, ARG388I, ARG506I, ARG88O, ASN29O, ASN391I, ASN465I, ASP172I, ASP18O, ASP193O, ASP195O, ASP265I, ASP266I, ASP368I, ASP369I, ASP392I, ASP50I, ASP521O, ASP55I, ASP56I, ASP59I, ASP74I, ASP74O, ASP85O, ASP91O, GLN21O, GLN231I, GLN363I, GLN76I, GLN90O, GLU117O, GLU215I, GLU258O, GLU370I, GLU522O, GLU93O, GLY119O, GLY128O, GLY16O, GLY170I, GLY210I, GLY22O, GLY389I, GLY48I, GLY58I, HIS123O, HIS209I, HIS263O, HIS77O, ILE120O, ILE125O, ILE168I, ILE169I, ILE262I, ILE26O, ILE505I, ILE524O, ILE57I, ILE86O, LEU116O, LEU124O, LEU198O, LEU49I, LEU504I, LEU53I, LEU73I, LEU83O, LYS127O, LYS131O, LYS167I, LYS211I, LYS235I, LYS23O, LYS365I, LYS468I, LYS51I, LYS527O, LYS81O, MET126O, MET52I, PHE175I, PHE176I, PHE366I, PHE60I, PRO46I, PRO78O, SER121O, SER122O, SER134O, SER166I, SER173I, SER20O, SER212I, SER367I, SER394I, SER42I, SER519O, SER87O, THR17O, THR214I, THR61I, THR82O, TYR129O, TYR393I, VAL101O, VAL133O, VAL137O, VAL39I, VAL47I, VAL54I, VAL62I, VAL75O, VAL76O, VAL84O, VAL94O
• J-K: ALA129J, ALA15J, ALA256J, ALA259J, ALA27K, ALA28K, ALA305K, ALA309J, ALA30K, ALA318J, ALA43K, ALA460K, ALA496J, ALA501J, ALA504J, ALA505J, ALA517J, ALA71K, ALA73J, ALA74J, ALA74K, ALA75K, ARG125J, ARG19J, ARG236K, ARG271K, ARG287J, ARG316J, ARG382K, ARG495J, ARG510J, ARG516J, ARG518J, ARG66K, ASN189J, ASN235J, ASN260K, ASN270K, ASN286J, ASN395K, ASN459K, ASN513J, ASN59K, ASN71J, ASN79J, ASP213K, ASP216K, ASP239J, ASP241J, ASP253J, ASP268K, ASP303K, ASP310J, ASP330J, ASP362K, ASP387K, ASP50K, ASP512J, ASP69K, ASP70J, ASP85J, ASP86J, CYS335J, CYS38K, GLN118J, GLN258K, GLN260J, GLN274K, GLN279K, GLN281K, GLN306K, GLN458K, GLN4J, GLN84J, GLU122J, GLU12J, GLU13J, GLU191J, GLU251K, GLU262K, GLU264K, GLU266K, GLU267J, GLU267K, GLU276K, GLU277K, GLU278K, GLU315J, GLU324J, GLU358K, GLU363K, GLU391K, GLU503J, GLU506J, GLU67K, GLU87J, GLY123J, GLY211K, GLY212K, GLY247J, GLY255K, GLY313J, GLY322J, GLY323J, GLY361K, GLY383K, GLY384K, GLY461K, GLY53K, GLY54K, GLY7J, HIS116J, HIS166K, HIS192J, HIS231K, HIS237K, HIS307K, HIS308J, HIS72K, ILE121J, ILE165K, ILE209K, ILE233J, ILE245J, ILE261K, ILE263K, ILE272K, ILE275K, ILE35K, ILE360K, ILE388K, ILE392K, ILE514J, ILE515J, ILE5J, ILE64K, ILE68K, ILE80J, LEU126J, LEU132J, LEU190J, LEU215K, LEU258J, LEU261J, LEU273K, LEU304K, LEU310K, LEU317J, LEU319J, LEU389K, LEU45K, LEU48K, LEU49K, LEU508J, LEU509J, LEU55K, LEU57K, LEU69J, LEU77J, LYS162K, LYS185J, LYS233K, LYS242J, LYS244J, LYS249J, LYS251J, LYS253K, LYS254K, LYS257J, LYS263J, LYS265K, LYS311K, LYS386K, LYS42K, LYS46K, LYS492J, LYS75J, LYS76K, LYS82J, MET234K, MET359K, MET44K, MET47K, MET52K, PHE246J, PHE250J, PHE311J, PHE329J, PHE365K, PHE6J, PRO117J, PRO210K, PRO232K, PRO41K, PRO51K, PRO72J, PRO73K, SER187J, SER23K, SER302K, SER327J, SER385K, SER499J, SER500J, SER502J, SER81J, THR119J, THR11J, THR161K, THR188J, THR236J, THR240J, THR248J, THR255J, THR259K, THR321J, THR37K, TRP167K, TRP269K, TYR124J, TYR163K, TYR252K, TYR308K, TYR364K, VAL10J, VAL164K, VAL214K, VAL229K, VAL230K, VAL243J, VAL252J, VAL280K, VAL314J, VAL31K, VAL320J, VAL325J, VAL326J, VAL34K, VAL357K, VAL3J, VAL507J, VAL511J, VAL56K, VAL70K, VAL76J, VAL78J, VAL83J, VAL88J
• J-M: LYS249J, LYS251J, LYS284M, LYS286M, PHE250J, THR248J, THR283M
• J-N: ALA10N, ALA184N, ALA186N, ALA18N, ALA263N, ALA264J, ALA264N, ALA26J, ALA272N, ALA28J, ALA336N, ALA372J, ALA448J, ALA49J, ALA520N, ALA524N, ALA536N, ALA73J, ALA73N, ALA74J, ALA77N, ALA79N, ALA80N, ALA81N, ALA82N, ARG116N, ARG14N, ARG15N, ARG259N, ARG322N, ARG323N, ARG370J, ARG511N, ARG514N, ARG535N, ARG538N, ARG78N, ASN188N, ASN220J, ASN221J, ASN22N, ASN237N, ASN248N, ASN338N, ASN404N, ASN447J, ASN475J, ASN515N, ASN526N, ASN52J, ASN58J, ASN71J, ASN7N, ASP120N, ASP187N, ASP190N, ASP205J, ASP239J, ASP241J, ASP253J, ASP260N, ASP292J, ASP300J, ASP31J, ASP342N, ASP374J, ASP43J, ASP446J, ASP531N, ASP70J, ASP84N, CYS530N, CYS54J, GLN168J, GLN185N, GLN222J, GLN258N, GLN260J, GLN296J, GLN298N, GLN329N, GLN337N, GLN346N, GLN351J, GLN375J, GLN47J, GLN4N, GLN69N, GLN83N, GLU11N, GLU123N, GLU246N, GLU262J, GLU265J, GLU266N, GLU267J, GLU295J, GLU326N, GLU335N, GLU341N, GLU344J, GLU345J, GLU350J, GLU379J, GLU532N, GLU85N, GLY121N, GLY200J, GLY201J, GLY219J, GLY247J, GLY250N, GLY25J, GLY333N, GLY334N, GLY349J, GLY371J, GLY38J, GLY41J, GLY449J, GLY519N, GLY522N, GLY537N, HIS114N, HIS192N, ILE117N, ILE118N, ILE124N, ILE165J, ILE198J, ILE235N, ILE27J, ILE290J, ILE343J, ILE346J, ILE347N, ILE517N, ILE523N, ILE63J, ILE67J, ILE68N, ILE76N, ILE86N, LEU13N, LEU166J, LEU189N, LEU191N, LEU199J, LEU19N, LEU203J, LEU238J, LEU258J, LEU261J, LEU262N, LEU297J, LEU301J, LEU32J, LEU330N, LEU343N, LEU348J, LEU369J, LEU377J, LEU3N, LEU45J, LEU46J, LEU527N, LEU528N, LEU529N, LEU533N, LEU534N, LEU5N, LEU64J, LEU69J, LEU6N, LEU75N, LYS127N, LYS164J, LYS170J, LYS202J, LYS217J, LYS224J, LYS242J, LYS244J, LYS244N, LYS249J, LYS251J, LYS257J, LYS261N, LYS263J, LYS268J, LYS268N, LYS273N, LYS34J, LYS407N, LYS40J, LYS44J, LYS75J, LYS9N, MET193N, MET269J, MET325N, MET347J, MET42J, MET55J, PHE122N, PHE246J, PHE250J, PHE251N, PHE252N, PHE269N, PHE298J, PRO115N, PRO223J, PRO294J, PRO345N, PRO352J, PRO39J, PRO68J, PRO71N, PRO72J, PRO8N, SER12N, SER162J, SER163J, SER167J, SER204J, SER21J, SER239N, SER249N, SER254J, SER254N, SER255N, SER265N, SER2N, SER339N, SER344N, SER35J, SER48J, SER50J, SER51J, SER525N, SER539N, SER66J, SER70N, THR119N, THR240J, THR245N, THR248J, THR255J, THR299J, THR36J, THR373J, THR376J, THR440N, THR518N, THR521N, THR53J, THR57J, THR72N, THR87N, TYR253N, TYR291J, TYR293J, VAL113N, VAL21N, VAL238N, VAL243J, VAL247N, VAL24J, VAL252J, VAL29J, VAL33J, VAL340N, VAL56J, VAL74N, VAL78J, VAL94N, VAL98N
• K-L: ASN260K, GLN258K, ILE253L, MET260L, SER257K, THR259K, VAL254L
• K-N: ASN248N, GLU246N, GLY250N, ILE263K, PHE252N, SER249N, THR245N, TRP269K, VAL247N
• K-P: ALA389P, ARG202K, ARG522K, ASN52P, ASP199K, ASP268K, ASP396P, ASP524K, ASP76P, GLN12K, GLU281P, GLU341K, GLU362P, GLU515K, HIS268P, HIS311P, ILE54P, LYS265K, LYS278P, VAL527K, VAL56P
• L-O: ALA121L, ALA128L, ALA175O, ALA208O, ALA227O, ALA23L, ALA32O, ALA35O, ALA39O, ALA507L, ALA525L, ALA75L, ALA80O, ALA83L, ALA84L, ALA89L, ALA9L, ARG318L, ARG361O, ARG520L, ARG528L, ARG76L, ASN13L, ASN173O, ASN174O, ASN192L, ASN24L, ASN251L, ASN31O, ASN57O, ASN64O, ASN8L, ASP122L, ASP176O, ASP190L, ASP247L, ASP301O, ASP50O, ASP522L, ASP523L, ASP74O, CYS33O, CYS514L, GLN125L, GLN238L, GLN37O, GLN384O, GLN58O, GLN85L, GLU15L, GLU210O, GLU211O, GLU249L, GLU249O, GLU265O, GLU38O, GLU513L, GLU80L, GLU88L, GLY206O, GLY207O, GLY228O, GLY48O, HIS116L, HIS172O, HIS72L, HIS77O, ILE204O, ILE253L, ILE518L, ILE51O, ILE521L, ILE524L, ILE53O, ILE62O, ILE69O, ILE70L, LEU170O, LEU47O, LEU502L, LEU510L, LEU519L, LEU52O, LEU70O, LEU71L, LEU72O, LEU73O, LYS129L, LYS12L, LYS14L, LYS169O, LYS265L, LYS290L, LYS41O, LYS516L, LYS59O, LYS71O, LYS81O, MET209O, MET77L, PHE11L, PHE124L, PHE526L, PRO117L, PRO17L, PRO205O, PRO42O, PRO46O, PRO73L, SER126L, SER359O, SER49O, SER506L, SER512L, SER517L, SER527L, SER56O, SER63O, SER7L, SER87L, THR10L, THR118L, THR43O, THR505L, THR509L, THR55O, THR60O, THR61O, VAL132L, VAL20L, VAL259O, VAL261O, VAL34O, VAL36O, VAL54O, VAL74L, VAL75O, VAL76O, VAL81L, VAL84O
• L-P: ALA534P, ARG258L, ARG343P, GLN283P, HIS72L, LEU266P, LYS15P, LYS265L, LYS49L, MET47L, THR532P, THR536P, VAL254L
• M-N: ALA101M, ALA147M, ALA154M, ALA256N, ALA263N, ALA264N, ALA310N, ALA355M, ALA387N, ALA389N, ALA471N, ALA50N, ALA541M, ARG103N, ARG220N, ARG259N, ARG267N, ARG361M, ARG365M, ARG40M, ARG431M, ARG546M, ASN148M, ASN248N, ASN359M, ASN37M, ASN432M, ASN461N, ASN494N, ASN52N, ASN553M, ASN98M, ASP112M, ASP113M, ASP151M, ASP165N, ASP206N, ASP218M, ASP220M, ASP222M, ASP223N, ASP257N, ASP260N, ASP288M, ASP302N, ASP304M, ASP307N, ASP34M, ASP368M, ASP372M, ASP436M, ASP465N, ASP48N, ASP552M, ASP97M, CYS274M, CYS545M, GLN106M, GLN111M, GLN200N, GLN258N, GLN296M, GLN299M, GLN303M, GLN324M, GLN349M, GLN35M, GLN367M, GLN390N, GLN536M, GLN537M, GLN543M, GLN67N, GLU114M, GLU241N, GLU243N, GLU266N, GLU293M, GLU294M, GLU302M, GLU308M, GLU34N, GLU350M, GLU352M, GLU357N, GLU361N, GLU362N, GLU65N, GLU99M, GLY116M, GLY140M, GLY149M, GLY219N, GLY250N, GLY348M, GLY360M, GLY360N, GLY36M, GLY382N, GLY38N, GLY41N, GLY43M, GLY463N, GLY49N, GLY51N, GLY558M, HIS142M, HIS201N, HIS221N, HIS285M, HIS312N, HIS353M, HIS385N, HIS50M, ILE100M, ILE115M, ILE141M, ILE144M, ILE146M, ILE271M, ILE289M, ILE31M, ILE354M, ILE356M, ILE359N, ILE362M, ILE532M, ILE538M, ILE53N, ILE548M, ILE551M, ILE555M, ILE556M, ILE68N, LEU103M, LEU104M, LEU107M, LEU166N, LEU202N, LEU262N, LEU287M, LEU298M, LEU306N, LEU351M, LEU369M, LEU388N, LEU43N, LEU467N, LEU46N, LEU470N, LEU539M, LEU540M, LEU544M, LEU549M, LEU55N, LEU62N, LEU96M, LYS102M, LYS109M, LYS145M, LYS155M, LYS161N, LYS205N, LYS244N, LYS261N, LYS268N, LYS280M, LYS282M, LYS284M, LYS286M, LYS297M, LYS305M, LYS311N, LYS363N, LYS373M, LYS381N, LYS38M, LYS39M, LYS402M, LYS40N, LYS435M, LYS44N, LYS460N, LYS47M, LYS535M, LYS54N, LYS550M, LYS559M, LYS57N, MET199N, MET224N, MET304N, MET45N, MET472N, MET547M, MET66N, PHE221M, PHE251N, PHE252N, PHE306M, PHE309N, PHE366M, PHE464N, PRO143M, PRO204N, PRO222N, PRO275M, PRO278M, PRO279M, PRO281M, PRO303N, PRO364M, PRO39N, PRO466N, SER108M, SER110M, SER203N, SER249N, SER254N, SER255N, SER265N, SER290M, SER291M, SER305N, SER31N, SER357M, SER370M, SER383N, SER462N, SER557M, THR160N, THR245N, THR273M, THR283M, THR300M, THR358N, THR35N, THR384N, THR391N, THR42N, THR457N, THR542M, THR56N, THR64N, TRP325M, TYR242N, TYR253N, TYR295M, TYR301M, TYR386N, VAL105M, VAL122M, VAL162N, VAL219M, VAL247N, VAL308N, VAL32N, VAL363M, VAL469N, VAL473N, VAL47N, VAL554M, VAL61N