3P93

crystal structure of d-mannonate dehydratase from chromohalobacter salexigens complexed with mg,d-mannonate and 2-keto-3-deoxy-d- gluconate

• Total interactions analyzed: 28
• Total true interactions: 20
• Strongest Interaction:
  • Chains: E-F
  • Int. Res.: 223
  • Norm. En. per Res.: -4.3111
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-68.1803	-28.7891	-227.886	-324.8554	112	11	0	9335	3	54	56
A-D	-88.3017	27.7538	-336.598	-397.146	128	21	3	14336	2	36	49
A-E	-70.0776	-37.5421	-230.403	-338.0226	113	13	0	9513	3	53	56
A-G	0.0	5.5376	0.0	5.5376	2	0	0	0	0	6	2
A-H	-74.2741	-150.1329	-701.286	-925.693	222	25	23	27428	18	68	94
B-C	-75.0053	18.011	-334.076	-391.0703	130	13	5	13916	1	36	49
B-D	-73.5394	-145.7261	-717.064	-936.3296	223	30	23	27865	16	69	94
B-E	0.0	5.5072	0.0	5.5072	2	0	0	0	0	6	2
B-G	-79.7454	-32.232	-225.887	-337.8644	110	10	0	9455	3	53	56
C-D	-80.6495	-34.8105	-229.886	-345.346	112	13	0	9411	4	52	57
C-F	-70.4497	-34.3721	-228.18	-333.0018	112	13	0	9381	4	55	58
C-G	-66.1242	-159.118	-723.562	-948.8042	221	27	23	27718	18	68	95
C-H	0.0	5.4816	0.0	5.4816	2	0	0	0	0	6	2
D-F	0.0	5.8229	0.0	5.8229	2	0	0	0	0	6	2
D-H	-68.4245	-26.3069	-224.72	-319.4513	110	12	0	9449	3	54	56
E-F	-84.8956	-157.0824	-719.388	-961.366	223	30	23	27796	17	68	97
E-G	-62.7532	-26.0324	-218.277	-307.0626	111	13	0	9270	3	53	57
E-H	-68.1258	28.7616	-326.025	-365.3892	131	18	2	14143	1	37	49
F-G	-66.0878	12.5687	-357.604	-411.123	128	16	4	14580	2	39	49
F-H	-64.8766	-36.6759	-225.004	-326.5565	107	17	0	9427	3	55	56

Interface residues

• A-B: ALA223B, ALA224B, ALA229B, ALA244B, ARG116A, ARG118A, ARG146A, ARG201A, ARG217B, ARG225B, ARG251A, ARG251B, ARG254A, ARG311A, ARG396B, ASN191B, ASN246B, ASN279A, ASN337A, ASP206A, ASP207A, ASP283A, ASP332A, ASP399B, GLN247B, GLN278A, GLN280A, GLU117A, GLU187B, GLU222B, GLU231A, GLU245B, GLU248B, GLU255A, GLU255B, GLU398B, GLY156B, GLY205A, GLY227A, GLY227B, GLY339A, GLY400B, HIS192B, HIS209A, HIS216B, HIS234A, HIS256A, HIS256B, HIS309A, HIS364A, HIS404B, ILE221B, ILE253A, ILE253B, ILE277A, ILE282A, ILE340A, LEU190B, LEU208A, LEU218B, LEU226B, LEU235A, LEU250B, LEU252A, LEU252B, LEU261A, LEU304A, LEU307A, LEU397B, LEU402B, LYS114A, LYS188B, LYS195B, LYS228A, LYS228B, MET120A, PHE236A, PHE338A, PRO155B, PRO194B, PRO220B, PRO232A, PRO243B, PRO260A, PRO336A, SER115A, SER185B, SER249B, SER306A, THR186B, THR219B, THR257A, THR257B, THR258A, THR259A, THR333A, THR401B, TRP184B, TRP237A, TRP281A, TRP281B, TRP334A, TRP403B, TYR233A, TYR284A, TYR308A, VAL119A, VAL183B, VAL210A, VAL242B, VAL310A, VAL335A
• A-D: ALA100A, ALA100D, ALA102A, ALA102D, ALA103A, ALA103D, ALA297A, ALA302A, ALA302D, ALA305A, ALA305D, ALA62A, ALA62D, ARG116A, ARG116D, ARG118A, ARG118D, ARG274A, ARG274D, ARG299A, ARG299D, ARG300A, ARG300D, ARG311D, ARG60A, ARG60D, ARG64A, ARG64D, ARG74A, ARG74D, ARG79A, ARG79D, ASN279A, ASN279D, ASN337A, ASN337D, ASP303A, ASP303D, ASP61A, ASP61D, ASP67A, ASP67D, GLN109A, GLN109D, GLN278A, GLN278D, GLN280A, GLN280D, GLN70A, GLN70D, GLU117A, GLU117D, GLU275A, GLU275D, GLU66A, GLU66D, GLY104A, GLY104D, GLY112A, GLY112D, GLY113A, GLY113D, GLY63A, GLY63D, HIS271A, HIS271D, HIS309A, HIS309D, ILE270A, ILE270D, ILE277A, ILE277D, ILE295D, ILE65A, ILE65D, ILE98A, ILE98D, LEU107A, LEU107D, LEU110A, LEU110D, LEU111A, LEU111D, LEU304A, LEU304D, LEU307A, LEU307D, LEU3A, LEU3D, LEU95A, LEU95D, LYS101A, LYS101D, LYS114A, LYS114D, LYS99A, LYS99D, MET105A, MET105D, PRO106A, PRO106D, PRO336A, PRO336D, SER115A, SER115D, SER269D, SER306A, SER306D, THR296A, THR296D, THR333A, THR333D, THR68A, THR68D, TRP334A, TRP334D, TRP69A, TRP69D, TRP96A, TRP96D, TYR108A, TYR108D, TYR308A, TYR308D, VAL301A, VAL301D, VAL335A, VAL335D
• A-E: ALA223A, ALA224A, ALA229A, ALA244A, ARG116E, ARG118E, ARG146E, ARG201E, ARG217A, ARG225A, ARG251A, ARG251E, ARG254E, ARG311E, ARG396A, ASN191A, ASN246A, ASN279E, ASN337E, ASP206E, ASP207E, ASP283E, ASP332E, ASP399A, CYS241A, GLN247A, GLN278E, GLN280E, GLU117E, GLU187A, GLU222A, GLU231E, GLU245A, GLU248A, GLU255A, GLU255E, GLU398A, GLY156A, GLY205E, GLY227A, GLY227E, GLY339E, GLY400A, HIS209E, HIS216A, HIS234E, HIS256A, HIS256E, HIS309E, HIS364E, HIS404A, ILE221A, ILE253A, ILE253E, ILE277E, ILE282E, ILE340E, LEU190A, LEU208E, LEU218A, LEU226A, LEU235E, LEU250A, LEU252A, LEU252E, LEU261E, LEU276E, LEU304E, LEU307E, LEU397A, LEU402A, LYS114E, LYS188A, LYS195A, LYS228A, LYS228E, MET120E, PHE236E, PHE338E, PRO155A, PRO194A, PRO220A, PRO232E, PRO243A, PRO260E, PRO336E, SER115E, SER185A, SER249A, SER306E, THR186A, THR219A, THR257A, THR257E, THR258E, THR259E, THR333E, THR401A, TRP184A, TRP237E, TRP281A, TRP281E, TRP334E, TRP403A, TYR233E, TYR284E, TYR308E, VAL119E, VAL183A, VAL210E, VAL242A, VAL310E, VAL335E
• A-G: GLU255A, GLU255G
• A-H: ALA180A, ALA180H, ALA244A, ALA244H, ALA390A, ALA390H, ALA44A, ALA44H, ALA46A, ALA46H, ALA47A, ALA47H, ALA56A, ALA56H, ALA76A, ALA76H, ALA87A, ALA87H, ARG149H, ARG17A, ARG17H, ARG217A, ARG217H, ARG274A, ARG274H, ARG286H, ARG389A, ARG389H, ARG396A, ARG396H, ARG41A, ARG41H, ARG60A, ARG60H, ARG64A, ARG64H, ARG74A, ARG74H, ARG79A, ARG79H, ARG80A, ARG80H, ASN18A, ASN18H, ASN246A, ASN246H, ASN268A, ASN268H, ASN279A, ASN279H, ASN395A, ASN395H, ASN39A, ASN39H, ASP213A, ASP213H, ASP240A, ASP240H, ASP272A, ASP272H, ASP319A, ASP319H, ASP399A, ASP399H, ASP50A, ASP50H, ASP61A, ASP61H, ASP67A, ASP67H, CYS273A, CYS273H, GLN247A, GLN247H, GLN278A, GLN278H, GLN70A, GLN70H, GLU181A, GLU181H, GLU239A, GLU239H, GLU245A, GLU245H, GLU248A, GLU248H, GLU265A, GLU265H, GLU275A, GLU275H, GLU388A, GLU388H, GLU42A, GLU42H, GLU51A, GLU51H, GLU66A, GLU66H, GLY264A, GLY264H, GLY400A, GLY400H, GLY40A, GLY40H, GLY75A, GLY75H, GLY81A, GLY81H, HIS215A, HIS215H, HIS216A, HIS216H, HIS271A, HIS271H, HIS291A, HIS291H, HIS315A, HIS315H, HIS404A, HIS404H, HIS52A, HIS52H, ILE270A, ILE270H, ILE58A, ILE58H, ILE88A, ILE88H, LEU178A, LEU178H, LEU320A, LEU320H, LEU38A, LEU38H, LEU392A, LEU392H, LEU397A, LEU397H, LEU402A, LEU402H, LEU49A, LEU49H, LEU57A, LEU57H, LEU72A, LEU72H, MET287A, MET287H, MET43A, MET43H, MET85A, MET85H, PHE267A, PHE267H, PRO179A, PRO179H, PRO243A, PRO243H, PRO288A, PRO288H, PRO317A, PRO317H, PRO393A, PRO393H, PRO55A, PRO55H, PRO82A, PRO82H, SER177A, SER177H, SER249A, SER249H, SER269A, SER269H, SER391A, SER391H, THR37A, THR37H, THR401A, THR401H, THR68A, THR68H, THR84A, THR84H, THR86A, THR86H, TRP281A, TRP281H, TRP403A, TRP403H, TRP405A, TRP405H, TRP69A, TRP69H, TRP78A, TRP78H, TYR387A, TYR387H, TYR48A, TYR48H, TYR71A, TYR71H, TYR73A, TYR73H, TYR77A, TYR77H, VAL20A, VAL20H, VAL242A, VAL242H, VAL266A, VAL266H, VAL394A, VAL394H, VAL45A, VAL45H, VAL53A, VAL53H, VAL54A, VAL54H, VAL83A, VAL83H
• B-C: ALA100B, ALA100C, ALA102B, ALA102C, ALA103B, ALA103C, ALA297B, ALA297C, ALA302B, ALA302C, ALA305B, ALA305C, ALA62B, ALA62C, ARG116B, ARG116C, ARG118B, ARG118C, ARG274B, ARG274C, ARG299B, ARG299C, ARG300B, ARG300C, ARG60B, ARG60C, ARG64B, ARG64C, ARG74B, ARG74C, ARG79B, ARG79C, ASN279B, ASN279C, ASN337B, ASN337C, ASP303B, ASP303C, ASP61B, ASP61C, ASP67B, ASP67C, GLN109B, GLN109C, GLN278B, GLN278C, GLN280B, GLN280C, GLN70B, GLN70C, GLU117B, GLU117C, GLU275B, GLU275C, GLU66B, GLU66C, GLY104B, GLY104C, GLY112B, GLY112C, GLY113B, GLY113C, GLY63B, GLY63C, HIS271B, HIS271C, HIS309B, HIS309C, ILE270B, ILE270C, ILE277B, ILE277C, ILE295B, ILE295C, ILE65B, ILE65C, ILE98B, ILE98C, LEU107B, LEU107C, LEU110B, LEU110C, LEU111B, LEU111C, LEU304B, LEU304C, LEU307B, LEU307C, LEU3B, LEU3C, LEU95B, LEU95C, LYS101B, LYS101C, LYS114B, LYS114C, LYS99B, LYS99C, MET105B, MET105C, PRO106B, PRO106C, PRO336B, PRO336C, SER115B, SER115C, SER269C, SER306B, SER306C, THR296B, THR296C, THR333B, THR333C, THR68B, THR68C, TRP334B, TRP334C, TRP69B, TRP69C, TRP96B, TRP96C, TYR108B, TYR108C, TYR308B, TYR308C, TYR73C, VAL301B, VAL301C, VAL335B, VAL335C
• B-D: ALA174B, ALA180B, ALA180D, ALA244B, ALA244D, ALA390B, ALA390D, ALA44B, ALA44D, ALA46B, ALA46D, ALA47B, ALA47D, ALA56B, ALA56D, ALA76B, ALA76D, ALA87B, ALA87D, ARG149D, ARG17B, ARG17D, ARG217B, ARG217D, ARG274B, ARG274D, ARG286D, ARG389B, ARG389D, ARG396B, ARG396D, ARG41B, ARG41D, ARG60B, ARG60D, ARG64B, ARG64D, ARG74B, ARG74D, ARG79B, ARG79D, ARG80B, ARG80D, ASN18B, ASN18D, ASN246B, ASN246D, ASN268B, ASN268D, ASN279B, ASN279D, ASN395B, ASN395D, ASN39B, ASN39D, ASP213B, ASP213D, ASP240B, ASP240D, ASP272B, ASP272D, ASP319B, ASP319D, ASP399B, ASP399D, ASP50B, ASP50D, ASP61B, ASP61D, ASP67B, ASP67D, CYS273B, CYS273D, GLN247B, GLN247D, GLN278B, GLN278D, GLN70B, GLN70D, GLU181B, GLU181D, GLU239B, GLU239D, GLU245B, GLU245D, GLU248B, GLU248D, GLU265B, GLU265D, GLU275B, GLU275D, GLU388B, GLU388D, GLU42B, GLU42D, GLU51B, GLU51D, GLU66B, GLU66D, GLY264B, GLY264D, GLY400B, GLY400D, GLY40B, GLY40D, GLY75B, GLY75D, GLY81B, GLY81D, HIS215B, HIS215D, HIS216B, HIS216D, HIS271B, HIS271D, HIS291B, HIS291D, HIS315B, HIS315D, HIS404B, HIS404D, HIS52B, HIS52D, ILE270B, ILE270D, ILE58B, ILE58D, ILE88B, ILE88D, LEU178B, LEU178D, LEU320B, LEU320D, LEU38B, LEU38D, LEU392B, LEU392D, LEU397B, LEU397D, LEU402B, LEU402D, LEU49B, LEU49D, LEU57B, LEU57D, LEU72B, LEU72D, MET287B, MET287D, MET43B, MET43D, MET85B, MET85D, PHE267B, PHE267D, PRO179B, PRO179D, PRO243B, PRO243D, PRO288B, PRO288D, PRO317B, PRO317D, PRO393B, PRO393D, PRO55B, PRO55D, PRO82B, PRO82D, SER177B, SER177D, SER249B, SER249D, SER269B, SER269D, SER391B, SER391D, THR37B, THR37D, THR401B, THR401D, THR68B, THR68D, THR84B, THR84D, THR86B, THR86D, TRP281B, TRP281D, TRP403B, TRP403D, TRP405B, TRP405D, TRP69B, TRP69D, TRP78B, TRP78D, TYR387B, TYR387D, TYR48B, TYR48D, TYR71B, TYR71D, TYR73B, TYR73D, TYR77B, TYR77D, VAL20B, VAL20D, VAL242B, VAL242D, VAL266B, VAL266D, VAL394B, VAL394D, VAL45B, VAL45D, VAL53B, VAL53D, VAL54B, VAL54D, VAL83B, VAL83D
• B-E: GLU255B, GLU255E
• B-G: ALA223G, ALA224G, ALA229G, ALA244G, ARG116B, ARG118B, ARG146B, ARG201B, ARG217G, ARG225G, ARG251B, ARG251G, ARG254B, ARG311B, ARG396G, ASN191G, ASN246G, ASN279B, ASN337B, ASP206B, ASP207B, ASP283B, ASP332B, ASP399G, GLN247G, GLN278B, GLN280B, GLU117B, GLU187G, GLU222G, GLU231B, GLU245G, GLU248G, GLU255B, GLU255G, GLU398G, GLY156G, GLY205B, GLY227B, GLY227G, GLY339B, GLY400G, HIS209B, HIS216G, HIS234B, HIS256B, HIS256G, HIS309B, HIS364B, HIS404G, ILE221G, ILE253B, ILE253G, ILE277B, ILE282B, LEU190G, LEU208B, LEU218G, LEU226G, LEU235B, LEU250G, LEU252B, LEU252G, LEU261B, LEU276B, LEU307B, LEU397G, LEU402G, LYS114B, LYS188G, LYS195G, LYS228B, LYS228G, MET120B, PHE236B, PHE338B, PRO155G, PRO194G, PRO220G, PRO232B, PRO243G, PRO260B, PRO336B, SER115B, SER185G, SER249G, SER306B, THR186G, THR219G, THR257B, THR257G, THR258B, THR259B, THR333B, THR401G, TRP184G, TRP237B, TRP281B, TRP281G, TRP334B, TRP403G, TYR233B, TYR284B, TYR308B, VAL119B, VAL183G, VAL210B, VAL242G, VAL310B, VAL335B
• C-D: ALA223D, ALA224D, ALA229D, ALA244D, ARG116C, ARG118C, ARG146C, ARG201C, ARG217D, ARG225D, ARG251C, ARG251D, ARG254C, ARG311C, ARG396D, ASN191D, ASN246D, ASN279C, ASN337C, ASP206C, ASP207C, ASP283C, ASP332C, ASP399D, GLN247D, GLN278C, GLN280C, GLU117C, GLU187D, GLU222D, GLU231C, GLU245D, GLU248D, GLU255C, GLU255D, GLU398D, GLY156D, GLY205C, GLY227C, GLY227D, GLY339C, GLY400D, HIS192D, HIS209C, HIS216D, HIS234C, HIS256C, HIS256D, HIS309C, HIS364C, HIS404D, ILE221D, ILE253C, ILE253D, ILE277C, ILE282C, LEU190D, LEU208C, LEU218D, LEU226D, LEU235C, LEU250D, LEU252C, LEU252D, LEU261C, LEU276C, LEU304C, LEU307C, LEU397D, LEU402D, LYS114C, LYS188D, LYS195D, LYS228C, LYS228D, MET120C, PHE236C, PHE338C, PRO155D, PRO194D, PRO220D, PRO232C, PRO243D, PRO260C, PRO336C, SER115C, SER185D, SER249D, SER306C, THR186D, THR219D, THR257C, THR257D, THR258C, THR259C, THR333C, THR401D, TRP184D, TRP237C, TRP281C, TRP281D, TRP334C, TRP403D, TYR233C, TYR284C, TYR308C, VAL119C, VAL183D, VAL210C, VAL242D, VAL310C, VAL335C
• C-F: ALA223C, ALA224C, ALA229C, ALA244C, ARG116F, ARG118F, ARG146F, ARG201F, ARG217C, ARG225C, ARG251C, ARG251F, ARG254F, ARG311F, ARG396C, ASN191C, ASN246C, ASN279F, ASN337F, ASP206F, ASP207F, ASP283F, ASP332F, ASP399C, GLN247C, GLN278F, GLN280F, GLU117F, GLU187C, GLU222C, GLU231F, GLU245C, GLU248C, GLU255C, GLU255F, GLU398C, GLY156C, GLY205F, GLY227C, GLY227F, GLY339F, GLY400C, HIS209F, HIS216C, HIS234F, HIS256C, HIS256F, HIS309F, HIS364F, HIS404C, ILE221C, ILE253C, ILE253F, ILE277F, ILE282F, ILE340F, LEU190C, LEU208F, LEU218C, LEU226C, LEU235F, LEU250C, LEU252C, LEU252F, LEU261F, LEU276F, LEU304F, LEU307F, LEU397C, LEU402C, LYS114F, LYS188C, LYS195C, LYS228C, LYS228F, MET120F, PHE236F, PHE338F, PRO155C, PRO194C, PRO220C, PRO232F, PRO243C, PRO260F, PRO336F, SER115F, SER185C, SER249C, SER306F, THR186C, THR219C, THR257C, THR257F, THR258F, THR259F, THR333F, THR401C, TRP184C, TRP237F, TRP281C, TRP281F, TRP334F, TRP403C, TYR233F, TYR284F, TYR308F, VAL119F, VAL183C, VAL210F, VAL242C, VAL310F, VAL335F
• C-G: ALA180C, ALA180G, ALA244C, ALA244G, ALA390C, ALA390G, ALA44C, ALA44G, ALA46C, ALA46G, ALA47C, ALA47G, ALA56C, ALA56G, ALA76C, ALA76G, ALA87C, ALA87G, ARG149C, ARG17C, ARG17G, ARG217C, ARG217G, ARG274C, ARG274G, ARG286C, ARG389C, ARG389G, ARG396C, ARG396G, ARG41C, ARG41G, ARG60C, ARG60G, ARG64C, ARG64G, ARG74C, ARG74G, ARG79C, ARG79G, ARG80C, ARG80G, ASN18C, ASN18G, ASN246C, ASN246G, ASN268C, ASN268G, ASN279G, ASN395C, ASN395G, ASN39C, ASN39G, ASP213C, ASP213G, ASP240C, ASP240G, ASP272C, ASP272G, ASP319C, ASP319G, ASP399C, ASP399G, ASP50C, ASP50G, ASP61C, ASP61G, ASP67C, ASP67G, CYS273C, CYS273G, GLN247C, GLN247G, GLN278C, GLN278G, GLN70C, GLN70G, GLU181C, GLU181G, GLU239C, GLU239G, GLU245C, GLU245G, GLU248C, GLU248G, GLU265C, GLU265G, GLU275C, GLU275G, GLU388C, GLU388G, GLU42C, GLU42G, GLU51C, GLU51G, GLU66C, GLU66G, GLY264C, GLY264G, GLY400C, GLY400G, GLY40C, GLY40G, GLY75C, GLY75G, GLY81C, GLY81G, HIS215C, HIS215G, HIS216C, HIS216G, HIS271C, HIS271G, HIS291C, HIS291G, HIS315C, HIS315G, HIS404C, HIS404G, HIS52C, HIS52G, ILE270C, ILE270G, ILE58C, ILE58G, ILE88C, ILE88G, LEU178C, LEU178G, LEU320C, LEU320G, LEU38C, LEU38G, LEU392C, LEU392G, LEU397C, LEU397G, LEU402C, LEU402G, LEU49C, LEU49G, LEU57C, LEU57G, LEU72C, LEU72G, MET287C, MET287G, MET43C, MET43G, MET85C, MET85G, PHE267C, PHE267G, PRO179C, PRO179G, PRO243C, PRO243G, PRO288C, PRO288G, PRO317C, PRO317G, PRO393C, PRO393G, PRO55C, PRO55G, PRO82C, PRO82G, SER177C, SER177G, SER249C, SER249G, SER269C, SER269G, SER391C, SER391G, THR37C, THR37G, THR401C, THR401G, THR68C, THR68G, THR84C, THR84G, THR86C, THR86G, TRP281C, TRP281G, TRP403C, TRP403G, TRP405C, TRP405G, TRP69C, TRP69G, TRP78C, TRP78G, TYR387C, TYR387G, TYR48C, TYR48G, TYR71C, TYR71G, TYR73C, TYR73G, TYR77C, TYR77G, VAL20C, VAL20G, VAL242C, VAL242G, VAL266C, VAL266G, VAL394C, VAL394G, VAL45C, VAL45G, VAL53C, VAL53G, VAL54C, VAL54G, VAL83C, VAL83G
• C-H: GLU255C, GLU255H
• D-F: GLU255D, GLU255F
• D-H: ALA223H, ALA224H, ALA229H, ALA244H, ARG116D, ARG118D, ARG146D, ARG201D, ARG217H, ARG225H, ARG251D, ARG251H, ARG254D, ARG311D, ARG396H, ASN191H, ASN246H, ASN279D, ASN337D, ASP206D, ASP207D, ASP283D, ASP332D, ASP399H, GLN247H, GLN278D, GLN280D, GLU117D, GLU187H, GLU222H, GLU231D, GLU245H, GLU248H, GLU255D, GLU255H, GLU398H, GLY156H, GLY205D, GLY227D, GLY227H, GLY339D, GLY400H, HIS209D, HIS216H, HIS234D, HIS256D, HIS256H, HIS309D, HIS364D, HIS404H, ILE221H, ILE253D, ILE253H, ILE277D, ILE282D, LEU190H, LEU208D, LEU218H, LEU226H, LEU235D, LEU250H, LEU252D, LEU252H, LEU261D, LEU276D, LEU304D, LEU307D, LEU397H, LEU402H, LYS114D, LYS188H, LYS195H, LYS228D, LYS228H, MET120D, PHE236D, PHE338D, PRO155H, PRO194H, PRO220H, PRO232D, PRO243H, PRO260D, PRO336D, SER115D, SER185H, SER249H, SER306D, THR186H, THR219H, THR257D, THR257H, THR258D, THR259D, THR333D, THR401H, TRP184H, TRP237D, TRP281D, TRP281H, TRP334D, TRP403H, TYR233D, TYR284D, TYR308D, VAL119D, VAL210D, VAL242H, VAL310D, VAL335D
• E-F: ALA174E, ALA180E, ALA180F, ALA244E, ALA244F, ALA390E, ALA390F, ALA44E, ALA44F, ALA46E, ALA46F, ALA47E, ALA47F, ALA56E, ALA56F, ALA76E, ALA76F, ALA87E, ALA87F, ARG149F, ARG17E, ARG17F, ARG217E, ARG217F, ARG274E, ARG274F, ARG286F, ARG389E, ARG389F, ARG396E, ARG396F, ARG41E, ARG41F, ARG60E, ARG60F, ARG64E, ARG64F, ARG74E, ARG74F, ARG79E, ARG79F, ARG80E, ARG80F, ASN18E, ASN18F, ASN246E, ASN246F, ASN268E, ASN268F, ASN279E, ASN279F, ASN395E, ASN395F, ASN39E, ASN39F, ASP213E, ASP213F, ASP240E, ASP240F, ASP272E, ASP272F, ASP319E, ASP319F, ASP399E, ASP399F, ASP50E, ASP50F, ASP61E, ASP61F, ASP67E, ASP67F, CYS273E, CYS273F, GLN247E, GLN247F, GLN278E, GLN278F, GLN70E, GLN70F, GLU181E, GLU181F, GLU239E, GLU239F, GLU245E, GLU245F, GLU248E, GLU248F, GLU265E, GLU265F, GLU275E, GLU275F, GLU388E, GLU388F, GLU42E, GLU42F, GLU51E, GLU51F, GLU66E, GLU66F, GLY264E, GLY264F, GLY400E, GLY400F, GLY40E, GLY40F, GLY75E, GLY75F, GLY81E, GLY81F, HIS215E, HIS215F, HIS216E, HIS216F, HIS271E, HIS271F, HIS291E, HIS291F, HIS315E, HIS315F, HIS404E, HIS404F, HIS52E, HIS52F, ILE270E, ILE270F, ILE58E, ILE58F, ILE88E, ILE88F, LEU178E, LEU178F, LEU320E, LEU320F, LEU38E, LEU38F, LEU392E, LEU392F, LEU397E, LEU397F, LEU402E, LEU402F, LEU49E, LEU49F, LEU57E, LEU57F, LEU72E, LEU72F, MET287E, MET287F, MET43E, MET43F, MET85E, MET85F, PHE267E, PHE267F, PRO179E, PRO179F, PRO243E, PRO243F, PRO288E, PRO288F, PRO317E, PRO317F, PRO393E, PRO393F, PRO55E, PRO55F, PRO82E, PRO82F, SER177E, SER177F, SER249E, SER249F, SER269E, SER269F, SER391E, SER391F, THR37E, THR37F, THR401E, THR401F, THR68E, THR68F, THR84E, THR84F, THR86E, THR86F, TRP281E, TRP281F, TRP403E, TRP403F, TRP405E, TRP405F, TRP69E, TRP69F, TRP78E, TRP78F, TYR387E, TYR387F, TYR48E, TYR48F, TYR71E, TYR71F, TYR73E, TYR73F, TYR77E, TYR77F, VAL20E, VAL20F, VAL242E, VAL242F, VAL266E, VAL266F, VAL394E, VAL394F, VAL45E, VAL45F, VAL53E, VAL53F, VAL54E, VAL54F, VAL83E, VAL83F
• E-G: ALA223E, ALA224E, ALA229E, ALA244E, ARG116G, ARG118G, ARG146G, ARG201G, ARG217E, ARG225E, ARG251E, ARG251G, ARG254G, ARG311G, ARG396E, ASN191E, ASN246E, ASN279G, ASN337G, ASP206G, ASP207G, ASP283G, ASP332G, ASP399E, GLN247E, GLN278G, GLN280G, GLU117G, GLU187E, GLU222E, GLU231G, GLU245E, GLU248E, GLU255E, GLU255G, GLU398E, GLY156E, GLY205G, GLY227E, GLY227G, GLY339G, GLY400E, HIS209G, HIS216E, HIS234G, HIS256E, HIS256G, HIS309G, HIS364G, HIS404E, ILE221E, ILE253E, ILE253G, ILE277G, ILE282G, LEU190E, LEU208G, LEU218E, LEU226E, LEU235G, LEU250E, LEU252E, LEU252G, LEU261G, LEU276G, LEU304G, LEU307G, LEU397E, LEU402E, LYS114G, LYS188E, LYS195E, LYS228E, LYS228G, MET120G, PHE236G, PHE338G, PRO155E, PRO194E, PRO220E, PRO232G, PRO243E, PRO260G, PRO336G, SER115G, SER185E, SER249E, SER306G, THR186E, THR219E, THR257E, THR257G, THR258G, THR259G, THR333G, THR401E, TRP184E, TRP237G, TRP281E, TRP281G, TRP334G, TRP403E, TYR233G, TYR284G, TYR308G, VAL119G, VAL183E, VAL210G, VAL242E, VAL310G, VAL335G
• E-H: ALA100E, ALA100H, ALA102E, ALA102H, ALA103E, ALA103H, ALA297H, ALA302E, ALA302H, ALA305E, ALA305H, ALA62E, ALA62H, ARG116E, ARG116H, ARG118E, ARG118H, ARG274E, ARG274H, ARG299E, ARG299H, ARG300E, ARG300H, ARG311H, ARG60E, ARG60H, ARG64E, ARG64H, ARG74E, ARG74H, ARG79E, ARG79H, ASN279E, ASN279H, ASN337E, ASN337H, ASP303E, ASP303H, ASP61E, ASP61H, ASP67E, ASP67H, GLN109E, GLN109H, GLN278E, GLN278H, GLN280E, GLN280H, GLN70E, GLN70H, GLU117E, GLU117H, GLU275E, GLU275H, GLU66E, GLU66H, GLY104E, GLY104H, GLY112E, GLY112H, GLY113E, GLY113H, GLY63E, GLY63H, HIS271E, HIS271H, HIS309E, HIS309H, ILE270E, ILE270H, ILE277E, ILE277H, ILE295E, ILE295H, ILE65E, ILE65H, ILE98E, ILE98H, LEU107E, LEU107H, LEU110E, LEU110H, LEU111E, LEU111H, LEU304E, LEU304H, LEU307E, LEU307H, LEU3E, LEU3H, LEU95E, LEU95H, LYS101E, LYS101H, LYS114E, LYS114H, LYS99E, LYS99H, MET105E, MET105H, PHE338E, PRO106E, PRO106H, PRO336E, PRO336H, SER115E, SER115H, SER269E, SER269H, SER306E, SER306H, THR296E, THR296H, THR333E, THR333H, THR68E, THR68H, TRP334E, TRP334H, TRP69E, TRP69H, TRP96E, TRP96H, TYR108E, TYR108H, TYR308E, TYR308H, VAL301E, VAL301H, VAL335E, VAL335H
• F-G: ALA100F, ALA100G, ALA102F, ALA102G, ALA103F, ALA103G, ALA297F, ALA297G, ALA302F, ALA302G, ALA305G, ALA62F, ALA62G, ARG116F, ARG116G, ARG118F, ARG274F, ARG274G, ARG299F, ARG299G, ARG300F, ARG300G, ARG60F, ARG60G, ARG64F, ARG64G, ARG74F, ARG74G, ARG79F, ARG79G, ASN279F, ASN279G, ASN337F, ASN337G, ASP303F, ASP303G, ASP61F, ASP61G, ASP67F, ASP67G, GLN109F, GLN109G, GLN278F, GLN278G, GLN280F, GLN280G, GLN70F, GLN70G, GLU117F, GLU117G, GLU275F, GLU275G, GLU66F, GLU66G, GLY104F, GLY104G, GLY112F, GLY112G, GLY113F, GLY113G, GLY63F, GLY63G, HIS271F, HIS271G, HIS309F, HIS309G, ILE270F, ILE270G, ILE277F, ILE277G, ILE295F, ILE295G, ILE65F, ILE65G, ILE98F, ILE98G, LEU107F, LEU107G, LEU110F, LEU110G, LEU111F, LEU111G, LEU304F, LEU304G, LEU307F, LEU307G, LEU3F, LEU3G, LEU95F, LEU95G, LYS101F, LYS101G, LYS114F, LYS114G, LYS99F, LYS99G, MET105F, MET105G, PRO106F, PRO106G, PRO336F, PRO336G, SER115F, SER115G, SER269F, SER306F, SER306G, THR296F, THR296G, THR333F, THR333G, THR68F, THR68G, TRP334F, TRP334G, TRP69F, TRP69G, TRP96F, TRP96G, TYR108F, TYR108G, TYR308F, TYR308G, TYR73F, VAL301F, VAL301G, VAL335F, VAL335G
• F-H: ALA223F, ALA224F, ALA229F, ALA244F, ARG116H, ARG118H, ARG146H, ARG201H, ARG217F, ARG225F, ARG251F, ARG251H, ARG254H, ARG311H, ARG396F, ASN191F, ASN246F, ASN279H, ASN337H, ASP206H, ASP207H, ASP283H, ASP332H, ASP399F, GLN247F, GLN278H, GLN280H, GLU117H, GLU187F, GLU222F, GLU231H, GLU245F, GLU248F, GLU255F, GLU255H, GLU398F, GLY156F, GLY205H, GLY227F, GLY227H, GLY339H, GLY400F, HIS209H, HIS216F, HIS234H, HIS256F, HIS256H, HIS309H, HIS364H, HIS404F, ILE221F, ILE253F, ILE253H, ILE277H, ILE282H, LEU190F, LEU208H, LEU218F, LEU226F, LEU235H, LEU250F, LEU252F, LEU252H, LEU261H, LEU276H, LEU307H, LEU397F, LEU402F, LYS114H, LYS188F, LYS195F, LYS228F, LYS228H, MET120H, PHE236H, PHE338H, PRO155F, PRO194F, PRO220F, PRO232H, PRO243F, PRO260H, PRO336H, SER115H, SER185F, SER249F, SER306H, THR186F, THR219F, THR257F, THR257H, THR258H, THR259H, THR401F, TRP281F, TRP281H, TRP334H, TRP403F, TYR233H, TYR284H, TYR308H, VAL119H, VAL183F, VAL210H, VAL242F, VAL310H, VAL335H