3P6Z

structural basis of thrombin mediated factor v activation: essential role of the hirudin-like sequence glu666-glu672 for processing at the heavy chain-b domain junction

• Total interactions analyzed: 15
• Total true interactions: 5
• Strongest Interaction:
  • Chains: H-I
  • Int. Res.: 33
  • Norm. En. per Res.: -7.7069
• Hub Node: B(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-117.3843	-118.6164	377.709	141.7083	92	18	2	13496	10	44	33
B-C	-33.3918	-66.1934	-118.282	-217.8672	32	6	0	3849	3	13	6
B-H	-27.8749	-51.0867	-78.0365	-156.998	44	7	0	3472	3	30	29
G-H	-84.5785	-110.3546	114.473	-80.4601	86	22	2	12873	6	40	29
H-I	-51.2775	-82.9884	-120.063	-254.3289	33	5	0	3688	5	15	6

Interface residues

• A-B: ALA334A, ALA370B, ALA495B, ARG339A, ARG353A, ARG399B, ARG500B, ARG581B, ASN527B, ASN579B, ASN580B, ASP335A, ASP349A, ASP361A, ASP369B, ASP398B, ASP476B, CB8.1348532.25386, CYS336A, CYS482B, GLN494B, GLN584B, GLU333A, GLU333A5, GLU343A, GLU348A, GLU352A, GLU354A, GLU357A, GLU371B, GLY337A, GLY362A, GLY373B, GLY496B, GLY499B, HIS479B, ILE360A, ILE372B, ILE396B, ILE438B, ILE478B, ILE530B, ILE617B, LEU338A, LEU341A, LEU347A, LEU355A, LEU356A, LEU395B, LEU483B, LEU492B, LEU528B, LYS344A, LYS345A, LYS350A, LYS498B, LYS559B, LYS575B, LYS610B, MET374B, MET574B, MET585B, PHE342A, PHE474B, PHE572B, PHE578B, PRO340A, PRO376B, PRO480B, PRO529B, PRO577B, SER346A, SER358A, SER368B, SER375B, SER397B, SER475B, SER491B, SER576B, THR351A, TRP377B, TRP582B, TYR359A, TYR477B, TYR497B, TYR553B, TYR583B, VAL481B, VAL501B, VAL525B, VAL526B, VAL573B
• B-C: ARG383B, ARG425B, ARG431B, ARG433B, ARG436B, ASN437B, GLN387B, GLN519B, GLU388B, GLU435B, GLU439B, GLU666C, GLU669C, GLU672C, ILE441B, ILE667C, LEU389B, LEU390B, LEU423B, LYS428B, MET380B, PHE382B, PHE668C, PRO386B, PRO520B, PRO670C, PRO671C, SER430B, SER521B, THR432B, TRP504B, TYR434B
• B-H: ARG399B, ARG452H, ARG461H, ARG486H, ARG533H, ARG543H, ARG608H, ASN454H, ASN458H, ASN547H, ASP398B, ASP460H, ASP546H, ASP618B, GLN614B, GLN619B, GLU445B, GLU457H, GLU622B, GLY621B, HIS450H, ILE463H, ILE544H, ILE613H, ILE617B, LEU468B, LEU609H, LYS467B, LYS469B, LYS470B, LYS610H, LYS611H, LYS615B, LYS615H, PHE607H, PHE620B, PRO451H, PRO471B, SER397B, THR545H, TRP400B, TRP612H, TYR448B, VAL616B
• G-H: ALA334G, ALA370H, ALA495H, ARG339G, ARG353G, ARG500H, ARG581H, ASN527H, ASN579H, ASN580H, ASP335G, ASP349G, ASP361G, ASP369H, ASP476H, CYS336G, CYS482H, GLN494H, GLN584H, GLU343G, GLU348G, GLU352G, GLU354G, GLU357G, GLU371H, GLY337G, GLY362G, GLY373H, GLY496H, GLY499H, HIS479H, ILE360G, ILE372H, ILE396H, ILE438H, ILE478H, ILE530H, LEU338G, LEU341G, LEU347G, LEU355G, LEU356G, LEU395H, LEU483H, LEU492H, LEU528H, LYS344G, LYS345G, LYS350G, LYS498H, LYS559H, LYS575H, MET374H, MET574H, MET585H, PHE342G, PHE474H, PHE572H, PHE578H, PRO340G, PRO376H, PRO480H, PRO484H, PRO529H, PRO577H, SER346G, SER358G, SER368H, SER375H, SER397H, SER475H, SER491H, SER576H, THR351G, TRP377H, TRP582H, TYR359G, TYR477H, TYR497H, TYR553H, TYR583H, VAL481H, VAL501H, VAL525H, VAL526H, VAL573H
• H-I: ARG383H, ARG425H, ARG431H, ARG433H, ARG436H, ASN437H, GLN387H, GLN519H, GLU388H, GLU435H, GLU439H, GLU666I, GLU669I, GLU672I, ILE438H, ILE441H, ILE667I, LEU389H, LEU390H, LEU423H, LYS428H, MET380H, PHE382H, PHE668I, PRO386H, PRO520H, PRO670I, PRO671I, SER430H, SER673I, THR432H, TRP504H, TYR434H