3P5J

the structure of the human rnase h2 complex defines key interaction interfaces relevant to enzyme function and human disease

• Total interactions analyzed: 3
• Total true interactions: 3
• Strongest Interaction:
  • Chains: B-C
  • Int. Res.: 190
  • Norm. En. per Res.: -5.1123
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-46.4485	-9.5341	-206.99	-262.9726	83	6	10	8090	0	30	24
A-C	-94.3722	-30.3988	-457.85	-582.621	116	21	8	15857	3	27	23
B-C	-238.6951	-30.2942	-702.356	-971.3453	190	40	29	27046	1	25	30

Interface residues

• A-B: ALA209B, ALA295A, ALA296A, ALA49B, ARG13B, ARG207B, ARG286A, ARG291A, ASN178B, ASN179B, ASN181B, ASN42B, ASN76B, ASP215B, ASP252A, ASP257A, GLN289A, GLN77B, GLU251A, GLU256A, GLU290A, GLU294A, GLU47B, GLU62B, GLU68B, GLY211B, GLY292A, GLY46B, GLY48B, HIS210B, HIS285A, HIS44B, HIS70B, HIS71B, HIS86B, ILE213B, ILE254A, ILE63B, LEU15B, LEU175B, LEU18B, LEU212B, LEU293A, LEU299A, LEU40B, LEU52B, LEU84B, LEU85B, LYS39B, LYS64B, LYS67B, LYS69B, PHE17B, PHE229A, PHE288A, PHE37B, PHE66B, PHE74B, PHE87B, PRO227A, PRO284A, PRO43B, SER214B, SER258A, SER297A, SER298A, SER45B, SER72B, SER78B, SER81B, THR50B, THR89B, TRP255A, TYR208B, TYR216B, TYR287A, TYR51B, VAL180B, VAL228A, VAL253A, VAL38B, VAL65B, VAL79B
• A-C: ALA144C, ALA149C, ALA156C, ALA250A, ALA42C, ALA51C, ALA61C, ARG109A, ARG148C, ARG236A, ARG286A, ARG291A, ARG40C, ARG46C, ARG53C, ARG64C, ARG66C, ARG69C, ASN100A, ASP143C, ASP226A, ASP252A, ASP257A, ASP35C, ASP45C, ASP55C, CYS34C, GLN233A, GLN243A, GLN289A, GLN60C, GLU137C, GLU247A, GLU249A, GLU251A, GLU256A, GLU290A, GLY108A, GLY12A, GLY135C, GLY151C, GLY230A, GLY292A, GLY65C, GLY67C, HIS147C, HIS160C, HIS224A, HIS30C, ILE102A, ILE122C, ILE14C, ILE159C, ILE254A, LEU101A, LEU107A, LEU136C, LEU150C, LEU155C, LEU203A, LEU246A, LEU293A, LEU299A, LEU32C, LEU37C, LEU68C, LYS111A, LYS145C, MET106A, MET84C, PHE229A, PHE231A, PHE237A, PHE288A, PHE47C, PHE48C, PHE63C, PRO140C, PRO153C, PRO227A, PRO232A, PRO284A, PRO33C, PRO41C, PRO43C, PRO50C, PRO99A, SER103A, SER105A, SER154C, SER238A, SER258A, SER298A, SER39C, SER62C, THR104A, THR11A, THR138C, THR49C, THR86C, TRP134C, TRP152C, TRP239A, TRP255A, TYR112A, TYR287A, VAL110A, VAL139C, VAL146C, VAL225A, VAL228A, VAL235A, VAL253A, VAL36C, VAL38C, VAL44C
• B-C: ALA11B, ALA124C, ALA12B, ALA144C, ALA149C, ALA156C, ALA157C, ALA158C, ALA161C, ALA174B, ALA177B, ALA209B, ALA24C, ALA25C, ALA26B, ALA27C, ALA42C, ALA61C, ALA74C, ALA80C, ALA88B, ARG120C, ARG13B, ARG148C, ARG17C, ARG22C, ARG40C, ARG46C, ARG64C, ASN169B, ASN178B, ASN179B, ASN181B, ASN76B, ASP124B, ASP143C, ASP215B, ASP25B, ASP35C, ASP45C, ASP92B, CYS34C, CYS56B, GLN14B, GLN162C, GLN170B, GLN77B, GLN80B, GLU133B, GLU21B, GLU62B, GLU68B, GLY123C, GLY126C, GLY135C, GLY151C, GLY19C, GLY23C, GLY78C, GLY81C, GLY82B, GLY83B, HIS130C, HIS140B, HIS147C, HIS15C, HIS160C, HIS22B, HIS30C, HIS70B, HIS71B, HIS86B, ILE122C, ILE14C, ILE159C, ILE213B, ILE53B, ILE63B, ILE75B, LEU121C, LEU133C, LEU134B, LEU136C, LEU150C, LEU155C, LEU15B, LEU16C, LEU175B, LEU18B, LEU19B, LEU212B, LEU21C, LEU23B, LEU29C, LEU31C, LEU32C, LEU35B, LEU36B, LEU37C, LEU52B, LEU60B, LEU68C, LEU84B, LEU85B, LEU94B, LEU96B, LYS136B, LYS145C, LYS167B, LYS176B, LYS24B, LYS28C, LYS39B, LYS64B, LYS67B, LYS69B, MET55B, MET84C, MET91B, PHE128C, PHE131C, PHE17B, PHE37B, PHE47C, PHE48C, PHE61B, PHE63C, PHE66B, PHE74B, PHE79C, PHE82C, PHE87B, PHE95B, PRO132B, PRO140C, PRO153C, PRO18C, PRO20B, PRO26C, PRO33C, PRO41C, PRO43B, PRO43C, PRO76C, PRO77C, PRO90B, PRO93B, SER127C, SER129C, SER137B, SER154C, SER20C, SER27B, SER34B, SER39C, SER62C, SER72B, SER78B, SER81B, THR125C, THR132C, THR171B, THR49C, THR50B, THR86C, THR89B, TRP134C, TRP152C, TRP163B, TRP73B, TYR208B, TYR216B, TYR51B, VAL146C, VAL168B, VAL16B, VAL172B, VAL173B, VAL180B, VAL36C, VAL38B, VAL38C, VAL44C, VAL52C, VAL65B, VAL73C, VAL75C, VAL79B, VAL83C, VAL85C