3P5B

the structure of the ldlr/pcsk9 complex reveals the receptor in an extended conformation

• Total interactions analyzed: 3
• Total true interactions: 3
• Strongest Interaction:
  • Chains: P-A
  • Int. Res.: 135
  • Norm. En. per Res.: -3.9123
• Hub Node: P(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
P-A	-115.8543	-34.0762	-378.231	-528.1614	135	22	16	14748	1	17	14
P-L	0.0	0.0	-2.712	-2.712	10	0	0	226	0	3	1
A-L	-55.1868	-18.1285	-145.188	-218.5033	57	11	4	5993	2	8	14

Interface residues

• P-A: ALA151P, ALA290A, ALA299A, ALA300A, ALA305A, ALA307A, ALA314A, ALA315A, ALA328A, ALA338A, ALA388A, ALA389A, ALA62P, ALA68P, ARG272A, ARG295A, ARG303A, ARG306A, ARG66P, ARG73P, ASN207A, ASN254A, ASN298A, ASN317A, ASN354A, ASP141P, ASP146P, ASP186A, ASP212A, ASP320A, ASP321A, CYS301A, CYS323A, CYS67P, GLN152P, GLN256A, GLN275A, GLN302A, GLN382A, GLN387A, GLU144P, GLU145P, GLU210A, GLU269A, GLU84P, GLU85P, GLY117P, GLY121P, GLY227A, GLY257A, GLY259A, GLY263A, GLY267A, GLY291A, GLY292A, GLY316A, GLY352A, GLY384A, HIS113P, HIS116P, HIS226A, HIS65P, ILE143P, ILE266A, ILE271A, LEU112P, LEU118P, LEU119P, LEU123P, LEU185A, LEU230A, LEU253A, LEU265A, LEU268A, LEU276A, LEU287A, LEU289A, LEU297A, LEU304A, LEU311A, LEU324A, LEU348A, LEU351A, LEU74P, LEU82P, LEU88P, LYS125P, LYS258A, LYS273A, LYS69P, LYS83P, PHE115P, PHE122P, PHE150P, PHE205A, PHE270A, PHE318A, PHE64P, PRO120P, PRO209A, PRO288A, PRO327A, PRO71P, SER147P, SER148P, SER262A, SER294A, SER326A, SER383A, SER386A, THR187A, THR260A, THR264A, THR313A, THR353A, THR385A, THR61P, THR63P, THR77P, THR86P, TRP72P, TYR142P, TYR293A, TYR325A, TYR78P, VAL114P, VAL124P, VAL149P, VAL252A, VAL261A, VAL296A, VAL309A, VAL79P, VAL80P, VAL81P
• P-L: ARG385L, ASN404L, ASP129P, GLY106P, HIS386L, LEU108P, LEU626L, PRO75P, SER127P, TYR107P
• A-L: ALA239A, ALA371A, ARG194A, ARG237A, ARG329L, ASN157A, ASN295L, ASN300L, ASN301L, ASN309L, ASP238A, ASP299L, ASP310L, ASP321L, ASP367A, ASP374A, CYS297L, CYS304L, CYS308L, CYS317L, CYS319L, CYS375A, CYS378A, GLN382A, GLU195A, GLU296L, GLU316L, GLY240A, GLY302L, GLY303L, GLY370A, HIS193A, HIS229A, HIS306L, ILE154A, ILE368A, ILE369A, LEU158A, LEU298L, LEU311L, LEU318L, LYS243A, LYS312L, PHE379A, PRO155A, PRO320L, SER153A, SER305L, SER372A, SER373A, SER376A, SER381A, THR377A, TRP156A, TYR315L, VAL307L, VAL380A