3P57

crystal structure of the p300 taz2 domain bound to mef2 on dna

• Total interactions analyzed: 78
• Total true interactions: 10
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 166
  • Norm. En. per Res.: -8.1845
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-269.8182	-154.6835	-934.124	-1358.6257	166	41	30	36070	14	70	46
A-J	0.0	0.0	-0.0131	-0.0131	2	0	0	9	0	0	1
A-P	0.0	-42.3281	-71.3783	-113.7064	36	2	2	3552	4	12	5
B-P	0.0	-47.1562	-71.8562	-119.0124	35	2	2	3231	2	12	6
C-D	-217.5508	-138.8873	-903.995	-1260.4332	167	43	27	35465	9	69	47
C-P	-14.3546	-2.0033	-63.6219	-79.9798	31	1	1	2660	0	9	6
D-P	-13.0133	-50.0512	-63.0855	-126.1501	31	6	1	3045	5	15	11
I-J	-239.7231	-140.5242	-896.06	-1276.3073	166	38	28	35444	11	69	45
I-P	0.0	-1.3763	-58.9626	-60.3389	45	2	0	2761	0	11	11
J-P	-2.6031	-24.2902	-47.8512	-74.7445	39	4	1	2615	2	16	7

Interface residues

• A-B: ALA32A, ALA32B, ALA44A, ALA44B, ALA58A, ALA58B, ALA87A, ALA87B, ARG10A, ARG10B, ARG17A, ARG17B, ARG24A, ARG24B, ARG79A, ARG79B, ASN16A, ASN16B, ASN49A, ASN49B, ASN52A, ASN52B, ASN73A, ASN73B, ASN81A, ASN81B, ASN89A, ASN89B, ASP40A, ASP40B, ASP61A, ASP61B, ASP63A, ASP63B, ASP83A, ASP83B, CYS39A, CYS39B, CYS41A, CYS41B, GLN18A, GLN18B, GLN56A, GLN56B, GLN7A, GLN7B, GLU14B, GLU34A, GLU34B, GLU42A, GLU42B, GLU71A, GLU71B, GLU74A, GLU74B, GLU77A, GLU77B, GLU86A, GLU86B, GLY27A, GLY27B, HIS76A, HIS76B, ILE11A, ILE11B, ILE43A, ILE43B, ILE46A, ILE46B, ILE47A, ILE47B, ILE6A, ILE6B, ILE84A, ILE84B, ILE8A, ILE8B, LEU28A, LEU28B, LEU35A, LEU35B, LEU38A, LEU38B, LEU45A, LEU45B, LEU54A, LEU54B, LEU66A, LEU66B, LEU67A, LEU67B, LEU88A, LEU88B, LYS23A, LYS23B, LYS25A, LYS25B, LYS30A, LYS30B, LYS31A, LYS31B, LYS53A, LYS53B, LYS5A, LYS64A, LYS64B, LYS68A, LYS68B, LYS91A, LYS91B, MET12A, MET12B, MET29A, MET29B, MET62A, MET62B, PHE21A, PHE21B, PHE26A, PHE26B, PHE48A, PHE48B, PHE55A, PHE55B, PRO75A, PRO75B, SER36A, SER36B, SER50A, SER50B, SER51A, SER51B, SER59A, SER59B, SER78A, SER78B, SER82A, SER82B, THR20A, THR20B, THR22A, THR22B, THR60A, THR60B, THR70A, THR70B, THR80A, THR80B, THR9A, THR9B, TYR33A, TYR33B, TYR57A, TYR57B, TYR69A, TYR69B, TYR72A, TYR72B, VAL19A, VAL19B, VAL37A, VAL37B, VAL65A, VAL65B, VAL85A, VAL85B
• A-J: ASN73A, LYS64J
• A-P: ALA103P, ARG107P, ARG108P, ARG92P, ARG99P, ASN73A, ASN86P, ASP61A, ASP63A, GLN101P, GLN102P, GLN104P, GLN89P, GLN93P, GLN94P, GLN95P, GLN97P, GLU71A, GLU74A, HIS76A, HIS98P, ILE46A, LEU100P, LEU66A, LEU67A, LEU96P, LYS64A, LYS68A, LYS90P, MET62A, PRO75A, SER78A, THR70A, TYR69A, TYR72A, VAL65A
• B-P: ALA103P, ARG107P, ARG92P, ARG99P, ASN73B, ASN77P, ASP61B, ASP63B, GLN101P, GLN102P, GLN56B, GLN89P, GLN93P, GLN94P, GLN95P, GLN97P, GLU71B, HIS98P, ILE46B, LEU100P, LEU106P, LEU54B, LEU66B, LEU67B, LEU91P, LEU96P, LYS64B, LYS68B, LYS88P, LYS90P, MET62B, THR70B, TYR69B, TYR72B, VAL65B
• C-D: ALA32C, ALA32D, ALA44C, ALA44D, ALA58C, ALA58D, ALA87C, ALA87D, ARG10C, ARG10D, ARG17C, ARG17D, ARG24C, ARG24D, ARG79C, ARG79D, ASN16C, ASN16D, ASN49C, ASN49D, ASN52C, ASN52D, ASN73C, ASN73D, ASN81C, ASN81D, ASN89C, ASN89D, ASP13D, ASP40C, ASP40D, ASP61C, ASP61D, ASP63C, ASP63D, ASP83C, ASP83D, CYS39C, CYS39D, CYS41C, CYS41D, GLN18C, GLN18D, GLN56C, GLN56D, GLN7C, GLN7D, GLU14D, GLU34C, GLU34D, GLU42C, GLU42D, GLU71C, GLU71D, GLU74C, GLU74D, GLU77C, GLU77D, GLU86D, GLY27C, GLY27D, HIS76C, HIS76D, ILE11C, ILE11D, ILE43C, ILE43D, ILE46C, ILE46D, ILE47C, ILE47D, ILE6C, ILE6D, ILE84C, ILE84D, ILE8C, ILE8D, LEU28C, LEU28D, LEU35C, LEU35D, LEU38C, LEU38D, LEU45C, LEU45D, LEU54C, LEU54D, LEU66C, LEU66D, LEU67C, LEU67D, LEU88C, LEU88D, LYS23C, LYS23D, LYS25C, LYS25D, LYS30C, LYS30D, LYS31C, LYS31D, LYS53C, LYS53D, LYS5C, LYS5D, LYS64C, LYS64D, LYS68C, LYS68D, LYS91C, LYS91D, MET12C, MET12D, MET29C, MET29D, MET62C, MET62D, PHE21C, PHE21D, PHE26C, PHE26D, PHE48C, PHE48D, PHE55C, PHE55D, PRO75C, PRO75D, SER36C, SER36D, SER50C, SER50D, SER51C, SER51D, SER59C, SER59D, SER78C, SER78D, SER82C, SER82D, THR20C, THR20D, THR22C, THR22D, THR60C, THR60D, THR70C, THR70D, THR80C, THR80D, THR9C, THR9D, TYR33C, TYR33D, TYR57C, TYR57D, TYR69C, TYR69D, TYR72C, TYR72D, VAL19C, VAL19D, VAL37C, VAL37D, VAL65C, VAL65D, VAL85C, VAL85D
• C-P: ALA23P, ARG15P, ASN73C, ASP63C, CYS16P, CYS26P, CYS36P, GLN14P, GLN18P, GLN25P, GLU71C, HIS22P, ILE17P, LEU11P, LEU20P, LEU33P, LEU66C, LEU67C, LYS64C, LYS68C, MET39P, PRO34P, SER12P, SER19P, SER32P, SER35P, THR70C, TYR69C, TYR72C, VAL21P, VAL65C
• D-P: ARG10P, ARG15P, ARG9P, ASN52D, ASN73D, ASP61D, ASP63D, ASP7P, GLN14P, GLN18P, GLU71D, GLY6P, HIS2P, HIS73P, ILE13P, ILE46D, LEU11P, LEU66D, LEU67D, LYS64D, LYS68D, MET3P, MET62D, SER12P, SER32P, SER4P, SER8P, THR60D, THR70D, TYR69D, VAL65D
• I-J: ALA32I, ALA32J, ALA44I, ALA44J, ALA58I, ALA58J, ALA87I, ALA87J, ARG10I, ARG10J, ARG17I, ARG17J, ARG24I, ARG24J, ARG79I, ARG79J, ASN16I, ASN16J, ASN49I, ASN49J, ASN52I, ASN52J, ASN73I, ASN73J, ASN81I, ASN81J, ASN89I, ASN89J, ASP40I, ASP40J, ASP61I, ASP61J, ASP63I, ASP63J, ASP83I, ASP83J, CYS39I, CYS39J, CYS41I, CYS41J, GLN18I, GLN18J, GLN56I, GLN56J, GLN7I, GLN7J, GLU14I, GLU34I, GLU34J, GLU42I, GLU42J, GLU71I, GLU71J, GLU74I, GLU74J, GLU77I, GLU77J, GLU86J, GLY27I, GLY27J, HIS76I, HIS76J, ILE11I, ILE11J, ILE43I, ILE43J, ILE46I, ILE46J, ILE47I, ILE47J, ILE6I, ILE6J, ILE84I, ILE84J, ILE8I, ILE8J, LEU28I, LEU28J, LEU35I, LEU35J, LEU38I, LEU38J, LEU45I, LEU45J, LEU54I, LEU54J, LEU66I, LEU66J, LEU67I, LEU67J, LEU88I, LEU88J, LYS23I, LYS23J, LYS25I, LYS25J, LYS30I, LYS30J, LYS31I, LYS31J, LYS53I, LYS53J, LYS5J, LYS64I, LYS64J, LYS68I, LYS68J, LYS90J, LYS91I, LYS91J, MET12I, MET12J, MET29I, MET29J, MET62I, MET62J, PHE21I, PHE21J, PHE26I, PHE26J, PHE48I, PHE48J, PHE55I, PHE55J, PRO75I, PRO75J, SER36I, SER36J, SER50I, SER50J, SER51I, SER51J, SER59I, SER59J, SER78I, SER78J, SER82I, SER82J, THR20I, THR20J, THR22I, THR22J, THR60I, THR60J, THR70I, THR70J, THR80I, THR80J, THR9I, THR9J, TYR33I, TYR33J, TYR57I, TYR57J, TYR69I, TYR69J, TYR72I, TYR72J, VAL19I, VAL19J, VAL37I, VAL37J, VAL65I, VAL65J, VAL85I, VAL85J
• I-P: ALA65P, ARG10P, ARG15P, ARG9P, ASN52I, ASN73I, ASP61I, ASP63I, ASP7P, CYS16P, GLN101P, GLN14P, GLN62P, GLN94P, GLN97P, GLU71I, GLU74I, GLY6P, HIS76I, HIS98P, ILE13P, ILE46I, ILE59P, LEU11P, LEU66I, LEU66P, LEU67I, LYS61P, LYS64I, LYS68I, MET3P, MET62I, PRO5P, PRO75I, SER12P, SER4P, SER51I, SER78I, SER8P, THR70I, THR80I, TYR69I, TYR69P, TYR72I, VAL65I
• J-P: ALA58J, ALA65P, ALA71P, ARG10P, ARG9P, ASP61J, ASP63J, CYS67P, CYS68P, GLN56J, GLN62P, GLN94P, GLU42J, GLU71J, GLY6P, HIS70P, HIS73P, HIS98P, ILE13P, ILE46J, ILE59P, ILE64P, ILE87P, LEU63P, LEU66J, LEU66P, LEU67J, LEU91P, LYS61P, LYS64J, LYS68J, LYS72P, LYS90P, MET62J, THR60J, THR70J, TYR69J, TYR69P, VAL65J