3P56

the structure of the human rnase h2 complex defines key interaction interfaces relevant to enzyme function and human disease

• Total interactions analyzed: 15
• Total true interactions: 6
• Strongest Interaction:
  • Chains: E-F
  • Int. Res.: 176
  • Norm. En. per Res.: -4.3812
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	0.0	-16.2215	-145.899	-162.1205	78	6	8	6441	0	23	18
A-C	-36.3625	-27.8316	-368.506	-432.7001	106	11	5	13210	3	19	23
B-C	-147.2905	-25.5705	-581.855	-754.716	179	27	25	23248	1	19	25
D-E	0.0	-13.9828	-136.305	-150.2878	77	3	9	6134	0	22	15
D-F	-30.5431	-28.5444	-342.2	-401.2876	105	9	6	12584	3	18	23
E-F	-155.9878	-25.4068	-589.696	-771.0905	176	24	26	23448	1	19	25

Interface residues

• A-B: ALA212B, ALA296A, ARG14B, ARG210B, ARG286A, ARG291A, ASN181B, ASN182B, ASN184B, ASN42B, ASN76B, ASP218B, ASP251A, ASP256A, CYS44B, GLN15B, GLN77B, GLN80B, GLU250A, GLU255A, GLU290A, GLU294A, GLU62B, GLU68B, GLY214B, GLY292A, HIS16B, HIS213B, HIS285A, HIS70B, HIS71B, HIS86B, ILE216B, ILE253A, ILE50B, LEU215B, LEU289A, LEU293A, LEU299A, LEU52B, LEU84B, LEU85B, LYS39B, LYS64B, LYS67B, LYS69B, PHE18B, PHE228A, PHE288A, PHE37B, PHE66B, PHE74B, PHE87B, PRO226A, PRO43B, SER217B, SER257A, SER284A, SER295A, SER298A, SER72B, SER78B, SER81B, THR297A, TRP254A, TRP73B, TYR211B, TYR219B, TYR287A, TYR51B, VAL17B, VAL183B, VAL227A, VAL252A, VAL38B, VAL63B, VAL65B, VAL79B
• A-C: ALA142C, ALA147C, ALA154C, ALA249A, ALA37C, ALA42C, ALA51C, ARG108A, ARG145C, ARG235A, ARG286A, ARG291A, ARG46C, ARG53C, ARG64C, ARG66C, ASN99A, ASP141C, ASP251A, ASP256A, ASP39C, CYS34C, CYS67C, GLN232A, GLN242A, GLU135C, GLU225A, GLU246A, GLU248A, GLU250A, GLU255A, GLU290A, GLU35C, GLU60C, GLY107A, GLY133C, GLY146C, GLY229A, GLY292A, GLY40C, GLY45C, GLY65C, HIS158C, HIS223A, HIS30C, ILE101A, ILE120C, ILE157C, ILE253A, LEU100A, LEU106A, LEU134C, LEU148C, LEU153C, LEU245A, LEU289A, LEU293A, LEU299A, LEU32C, LEU68C, LYS110A, LYS143C, MET105A, MET84C, PHE228A, PHE230A, PHE236A, PHE288A, PHE47C, PHE48C, PHE63C, PRO138C, PRO151C, PRO226A, PRO231A, PRO33C, PRO41C, PRO43C, PRO50C, PRO98A, SER102A, SER104A, SER237A, SER257A, SER62C, THR103A, THR11A, THR136C, THR149C, THR49C, THR86C, TRP132C, TRP150C, TRP254A, TYR287A, VAL109A, VAL144C, VAL14C, VAL224A, VAL227A, VAL234A, VAL252A, VAL36C, VAL38C, VAL44C, VAL61C
• B-C: ALA122C, ALA124C, ALA13B, ALA142C, ALA147C, ALA154C, ALA155C, ALA156C, ALA159C, ALA176B, ALA177B, ALA19C, ALA212B, ALA24C, ALA27B, ALA27C, ALA37C, ALA42C, ALA74C, ALA88B, ARG118C, ARG128C, ARG145C, ARG14B, ARG17C, ARG22C, ARG46C, ARG64C, ASN124B, ASN125C, ASN181B, ASN182B, ASN76B, ASP218B, ASP23C, ASP26B, ASP39C, ASP92B, CYS34C, GLN15B, GLN160C, GLN173B, GLN77B, GLN80B, GLU22B, GLU35C, GLU62B, GLU68B, GLY121C, GLY12B, GLY133B, GLY133C, GLY146C, GLY40C, GLY45C, GLY78C, GLY81C, GLY82B, GLY83B, HIS140B, HIS158C, HIS15C, HIS16B, HIS30C, HIS70B, HIS71B, HIS86B, ILE120C, ILE157C, ILE216B, ILE50B, ILE75B, LEU131C, LEU134C, LEU137B, LEU148C, LEU153C, LEU16C, LEU178B, LEU19B, LEU215B, LEU21C, LEU24B, LEU29C, LEU31C, LEU32C, LEU35B, LEU52B, LEU60B, LEU68C, LEU79C, LEU84B, LEU85B, LYS136B, LYS143C, LYS170B, LYS179B, LYS25B, LYS39B, LYS64B, LYS67B, LYS69B, MET36B, MET55B, MET84C, PHE119C, PHE126C, PHE129C, PHE18B, PHE37B, PHE47C, PHE48C, PHE53B, PHE61B, PHE63C, PHE66B, PHE74B, PHE87B, PHE95B, PRO138C, PRO151C, PRO26C, PRO33C, PRO41C, PRO43C, PRO50C, PRO76C, PRO77C, PRO90B, PRO93B, SER127C, SER152C, SER18C, SER21B, SER28B, SER62C, SER72B, SER78B, SER81B, THR123C, THR130C, THR149C, THR174B, THR180B, THR20C, THR28C, THR49C, THR86C, THR89B, TRP132C, TRP150C, TRP166B, TRP73B, TYR211B, TYR219B, TYR23B, TYR51B, TYR82C, VAL144C, VAL14C, VAL171B, VAL175B, VAL17B, VAL183B, VAL20B, VAL25C, VAL36C, VAL38B, VAL38C, VAL44C, VAL61C, VAL65B, VAL73C, VAL75C, VAL79B, VAL80C, VAL83C, VAL85C, VAL91B
• D-E: ALA212E, ALA296D, ALA49E, ARG14E, ARG210E, ARG286D, ARG291D, ASN182E, ASN184E, ASN42E, ASN76E, ASP218E, ASP251D, ASP256D, CYS44E, GLN15E, GLN77E, GLN80E, GLU250D, GLU255D, GLU290D, GLU294D, GLU62E, GLU68E, GLY214E, GLY292D, HIS16E, HIS213E, HIS285D, HIS70E, HIS71E, HIS86E, ILE216E, ILE253D, ILE50E, LEU215E, LEU289D, LEU293D, LEU299D, LEU52E, LEU84E, LEU85E, LYS39E, LYS64E, LYS67E, LYS69E, PHE18E, PHE228D, PHE288D, PHE37E, PHE66E, PHE74E, PHE87E, PRO226D, PRO43E, SER217E, SER257D, SER284D, SER295D, SER298D, SER72E, SER78E, SER81E, THR297D, TRP254D, TRP73E, TYR211E, TYR287D, TYR51E, VAL17E, VAL183E, VAL227D, VAL252D, VAL38E, VAL63E, VAL65E, VAL79E
• D-F: ALA142F, ALA147F, ALA154F, ALA249D, ALA37F, ALA42F, ALA51F, ARG108D, ARG145F, ARG235D, ARG291D, ARG46F, ARG53F, ARG64F, ARG66F, ARG69F, ASN99D, ASP141F, ASP251D, ASP256D, ASP39F, CYS34F, CYS67F, GLN232D, GLN242D, GLU135F, GLU222D, GLU225D, GLU246D, GLU248D, GLU250D, GLU255D, GLU290D, GLU35F, GLU60F, GLY107D, GLY133F, GLY146F, GLY229D, GLY292D, GLY40F, GLY45F, GLY65F, HIS223D, HIS30F, ILE101D, ILE120F, ILE157F, ILE253D, LEU100D, LEU106D, LEU134F, LEU148F, LEU153F, LEU245D, LEU289D, LEU293D, LEU299D, LEU32F, LEU68F, LYS143F, MET105D, MET84F, PHE228D, PHE230D, PHE236D, PHE288D, PHE47F, PHE48F, PHE63F, PRO138F, PRO151F, PRO226D, PRO231D, PRO33F, PRO41F, PRO43F, PRO50F, PRO98D, SER102D, SER104D, SER237D, SER257D, SER62F, THR103D, THR11D, THR136F, THR149F, THR49F, THR86F, TRP132F, TRP150F, TRP254D, TYR287D, VAL109D, VAL144F, VAL14F, VAL224D, VAL227D, VAL234D, VAL252D, VAL36F, VAL38F, VAL44F, VAL61F
• E-F: ALA122F, ALA124F, ALA13E, ALA142F, ALA147F, ALA154F, ALA155F, ALA156F, ALA159F, ALA176E, ALA177E, ALA19F, ALA212E, ALA24F, ALA27E, ALA27F, ALA37F, ALA42F, ALA74F, ALA88E, ARG118F, ARG128F, ARG145F, ARG14E, ARG17F, ARG22F, ARG46F, ARG64F, ASN124E, ASN125F, ASN181E, ASN182E, ASN54E, ASN76E, ASP218E, ASP23F, ASP26E, ASP39F, ASP92E, CYS34F, GLN15E, GLN160F, GLN173E, GLN77E, GLN80E, GLU22E, GLU35F, GLU62E, GLU68E, GLY121F, GLY12E, GLY133E, GLY133F, GLY146F, GLY34E, GLY40F, GLY45F, GLY78F, GLY81F, GLY82E, GLY83E, HIS158F, HIS15F, HIS16E, HIS30F, HIS70E, HIS71E, HIS86E, ILE120F, ILE157F, ILE216E, ILE50E, ILE75E, LEU131F, LEU137E, LEU148F, LEU153F, LEU16F, LEU178E, LEU19E, LEU215E, LEU21F, LEU24E, LEU29F, LEU31F, LEU32F, LEU35E, LEU52E, LEU60E, LEU68F, LEU79F, LEU84E, LEU85E, LYS143F, LYS170E, LYS179E, LYS25E, LYS39E, LYS64E, LYS67E, LYS69E, MET36E, MET55E, MET84F, PHE119F, PHE126F, PHE129F, PHE18E, PHE37E, PHE47F, PHE48F, PHE53E, PHE63F, PHE66E, PHE74E, PHE87E, PHE95E, PRO138F, PRO151F, PRO26F, PRO33F, PRO41F, PRO43F, PRO76F, PRO77F, PRO90E, PRO93E, SER127F, SER152F, SER18F, SER21E, SER28E, SER62F, SER72E, SER78E, SER81E, THR123F, THR130F, THR149F, THR174E, THR180E, THR20F, THR28F, THR49F, THR86F, THR89E, TRP132F, TRP150F, TRP73E, TYR208E, TYR211E, TYR219E, TYR23E, TYR51E, TYR82F, VAL144F, VAL14F, VAL171E, VAL175E, VAL17E, VAL183E, VAL20E, VAL25F, VAL36F, VAL38E, VAL38F, VAL44F, VAL61F, VAL65E, VAL73F, VAL75F, VAL79E, VAL80F, VAL83F, VAL85F, VAL91E