3P45

crystal structure of apo-caspase-6 at physiological ph

• Total interactions analyzed: 120
• Total true interactions: 28
• Strongest Interaction:
  • Chains: K-L
  • Int. Res.: 127
  • Norm. En. per Res.: -4.9067
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-135.0117	-24.233	-472.052	-631.2968	139	17	7	18741	2	35	33
A-D	-6.6632	-21.2691	-50.9034	-78.8357	24	8	0	2088	0	9	6
A-E	-41.1355	58.015	-142.899	-126.0195	70	16	4	6230	5	39	34
A-M	0.0	12.0467	-16.3924	-4.3457	9	0	0	587	0	1	5
B-C	-7.5177	-16.401	-50.9049	-74.8235	25	3	0	1993	1	9	6
B-D	-44.1832	-4.234	-241.889	-290.3062	85	23	6	10466	4	18	13
C-D	-127.7649	-28.1542	-448.034	-603.9531	133	20	6	17681	2	34	32
C-G	-39.0018	77.2829	-152.792	-114.5109	68	14	6	6594	6	38	34
E-F	-132.1239	-20.5881	-454.869	-607.581	129	21	8	17687	2	34	32
E-H	-10.1287	-21.7362	-48.4029	-80.2678	26	8	0	2046	0	8	7
E-I	-9.1706	-15.3261	-8.2137	-32.7104	14	1	0	479	2	5	7
E-M	-10.4916	-16.6715	-61.2161	-88.3792	43	4	1	2915	1	24	30
F-G	-7.1373	-11.924	-30.3039	-49.3651	23	5	0	1218	0	7	7
F-H	-34.8459	5.1052	-207.401	-237.1417	80	12	3	8877	1	17	13
G-H	-143.6081	-22.4971	-445.585	-611.6902	127	23	7	17194	2	34	32
I-J	-120.4455	-17.8937	-447.218	-585.5572	132	24	7	17750	0	35	33
I-L	0.0	-29.5065	-57.3226	-86.8291	25	6	0	2117	1	8	6
I-M	-41.9364	54.5216	-125.927	-113.3417	71	18	5	6424	6	38	33
J-K	-4.5736	-23.3024	-62.026	-89.902	27	3	0	2239	2	9	10
J-L	-44.4504	-0.116	-208.023	-252.5894	80	11	5	8515	3	19	13
K-L	-148.4894	-30.4087	-444.249	-623.1472	127	25	6	17352	2	35	32
K-O	-30.8219	57.6821	-151.91	-125.0498	69	16	5	6451	6	36	32
M-N	-140.4735	-31.1348	-438.97	-610.5783	129	31	6	17762	3	35	33
M-O	0.0	0.0	-0.007	-0.007	2	0	0	7	0	0	0
M-P	-5.5074	-21.601	-58.1729	-85.2813	24	4	0	2199	0	8	6
N-O	0.0	-15.4471	-50.6142	-66.0613	25	1	0	2107	1	8	7
N-P	-64.2268	-2.9495	-218.39	-285.5663	78	29	3	8884	3	17	13
O-P	-118.5118	-24.235	-444.385	-587.1319	126	19	7	17389	3	32	32

Interface residues

• A-B: ALA111A, ALA162A, ALA202B, ALA204B, ALA279B, ALA34A, ALA69A, ARG42A, ARG43A, ARG44A, ARG64A, ARG65A, ARG71A, ARG76A, ARG77A, ASN125A, ASN224B, ASN51A, ASN73A, ASP110A, ASP112A, ASP146A, ASP205B, ASP231B, ASP32A, ASP40A, ASP70A, ASP72A, ASP80A, CYS113A, CYS116A, CYS148A, CYS163A, CYS209B, CYS233B, CYS277B, CYS68A, GLN137A, GLN161A, GLN230B, GLN274B, GLU123A, GLU135A, GLU234B, GLU244B, GLU35A, GLY122A, GLY124A, GLY141A, GLY145A, GLY153A, GLY203B, GLY225B, GLY237B, GLY240B, GLY45A, GLY66A, GLY82A, HIS126A, HIS287B, HIS41A, ILE136A, ILE157A, ILE159A, ILE160A, ILE229B, ILE49A, LEU119A, LEU139A, LEU142A, LEU151A, LEU200B, LEU207B, LEU232B, LEU236B, LEU248B, LEU249B, LEU282B, LEU286B, LEU74A, LEU81A, LYS144A, LYS147A, LYS154A, LYS156A, LYS238B, LYS284B, LYS285B, LYS291B, LYS36A, LYS38A, MET208B, MET235B, MET281B, MET39A, PHE114A, PHE118A, PHE143A, PHE158A, PHE206B, PHE245B, PHE278B, PHE288B, PHE289B, PHE31A, PHE78A, PHE83A, PRO155A, PRO201B, PRO276B, PRO290B, PRO33A, SER211B, SER226B, SER241B, SER242B, SER280B, SER79A, THR138A, THR140A, THR199B, THR222B, THR246B, THR283B, THR67A, THR75A, TRP227B, TYR198B, TYR210B, TYR228B, TYR239B, TYR37A, VAL115A, VAL117A, VAL152A, VAL212B, VAL223B, VAL252B, VAL256B
• A-D: ALA34A, ARG254D, ASN253D, ASP32A, GLN258D, GLU247D, GLU35A, LEU243D, LEU248D, LEU251D, LYS144A, LYS238D, LYS255D, LYS36A, MET235D, PHE31A, PRO33A, SER257D, THR250D, TYR239D, TYR37A, VAL252D, VAL256D, VAL275D
• A-E: ALA129A, ALA129E, ALA132A, ALA132E, ALA93A, ALA93E, ASN125A, ASN125E, ASP131A, ASP131E, GLU102A, GLU102E, GLU123A, GLU123E, GLU135A, GLU135E, GLU94A, GLU94E, GLU95A, GLU95E, GLY124A, GLY124E, HIS101A, HIS101E, HIS126A, HIS126E, HIS58A, HIS58E, ILE100A, ILE100E, ILE134A, ILE134E, ILE136A, ILE136E, LEU139A, LEU139E, LEU142A, LEU142E, LEU59A, LEU59E, LEU96A, LEU96E, LEU97A, LEU97E, LEU98A, LEU98E, LYS133A, LYS133E, LYS147E, LYS92A, LYS92E, LYS99A, LYS99E, PHE55A, PHE56A, PHE56E, SER104A, SER104E, THR105A, THR105E, THR138A, THR138E, THR60A, THR60E, TRP57A, TRP57E, TYR128A, TYR128E, TYR130A, TYR130E
• A-M: ALA109M, ARG42M, ARG43M, ASP110M, ASP40M, HIS41M, HIS58A, PHE56A, TRP57A
• B-C: ALA34C, ARG254B, ASN125C, ASN253B, ASP32C, GLN137C, GLN258B, GLU247B, GLU35C, LEU243B, LEU248B, LEU251B, LYS238B, LYS255B, LYS36C, MET235B, PHE31C, PRO33C, SER257B, THR250B, TYR198B, TYR239B, TYR37C, VAL252B, VAL256B
• B-D: ALA202B, ALA202D, ALA204B, ALA204D, ALA279B, ALA279D, ARG254B, ARG254D, ASN253B, ASN253D, ASP205B, ASP205D, CYS209B, CYS209D, CYS277B, CYS277D, GLN258B, GLN258D, GLN274B, GLN274D, GLU244B, GLU244D, GLU247B, GLU247D, GLY203B, GLY203D, HIS287B, LEU200B, LEU200D, LEU207B, LEU207D, LEU243B, LEU243D, LEU248B, LEU248D, LEU249B, LEU249D, LEU251B, LEU251D, LEU282B, LEU282D, LEU286B, LEU286D, LYS255B, LYS255D, LYS284B, LYS284D, LYS285B, LYS285D, MET208B, MET208D, MET281B, MET281D, PHE206B, PHE206D, PHE278B, PHE278D, PRO201B, PRO201D, PRO276B, PRO276D, SER211B, SER211D, SER257B, SER257D, SER280B, SER280D, THR199B, THR246B, THR246D, THR250B, THR250D, THR283B, THR283D, TYR198B, TYR210B, TYR210D, VAL212B, VAL212D, VAL252B, VAL252D, VAL256B, VAL256D, VAL275B, VAL275D
• C-D: ALA111C, ALA162C, ALA202D, ALA204D, ALA279D, ALA34C, ALA69C, ARG42C, ARG43C, ARG44C, ARG64C, ARG65C, ARG71C, ARG76C, ARG77C, ASN125C, ASN224D, ASN73C, ASP110C, ASP112C, ASP146C, ASP205D, ASP231D, ASP32C, ASP40C, ASP70C, ASP72C, ASP80C, CYS113C, CYS116C, CYS148C, CYS209D, CYS233D, CYS277D, CYS68C, GLN137C, GLN161C, GLN230D, GLN274D, GLU234D, GLU244D, GLU35C, GLU53C, GLU63C, GLY141C, GLY145C, GLY153C, GLY203D, GLY225D, GLY237D, GLY240D, GLY45C, GLY66C, GLY82C, HIS287D, HIS41C, ILE127C, ILE136C, ILE157C, ILE159C, ILE160C, ILE229D, ILE49C, LEU119C, LEU139C, LEU142C, LEU151C, LEU200D, LEU207D, LEU232D, LEU236D, LEU243D, LEU248D, LEU249D, LEU282D, LEU286D, LEU74C, LEU81C, LYS144C, LYS147C, LYS154C, LYS156C, LYS238D, LYS284D, LYS285D, LYS291D, LYS36C, LYS38C, MET208D, MET235D, MET281D, MET39C, PHE114C, PHE118C, PHE143C, PHE158C, PHE206D, PHE245D, PHE278D, PHE288D, PHE289D, PHE31C, PHE78C, PHE83C, PRO155C, PRO201D, PRO276D, PRO290D, PRO33C, SER211D, SER226D, SER241D, SER242D, SER280D, SER79C, THR138C, THR140C, THR222D, THR246D, THR283D, THR67C, THR75C, TRP227D, TYR210D, TYR228D, TYR239D, TYR37C, VAL115C, VAL117C, VAL152C, VAL212D, VAL223D, VAL256D
• C-G: ALA129C, ALA129G, ALA132C, ALA132G, ALA93C, ALA93G, ASN125C, ASN125G, ASP131C, ASP131G, GLU102C, GLU102G, GLU123C, GLU123G, GLU135C, GLU135G, GLU94C, GLU94G, GLU95C, GLU95G, GLY124C, GLY124G, HIS101C, HIS101G, HIS126C, HIS126G, HIS58C, HIS58G, ILE100C, ILE100G, ILE134C, ILE134G, ILE136C, LEU139C, LEU139G, LEU142C, LEU142G, LEU59C, LEU59G, LEU96C, LEU96G, LEU97C, LEU97G, LEU98C, LEU98G, LYS133C, LYS133G, LYS147C, LYS147G, LYS92C, LYS92G, LYS99C, LYS99G, PHE56C, PHE56G, SER104G, THR105C, THR105G, THR138C, THR138G, THR60C, THR60G, TRP57C, TRP57G, TYR128C, TYR128G, TYR130C, TYR130G
• E-F: ALA111E, ALA162E, ALA202F, ALA204F, ALA279F, ALA34E, ALA69E, ARG42E, ARG43E, ARG44E, ARG64E, ARG65E, ARG71E, ARG76E, ARG77E, ASN125E, ASN224F, ASN73E, ASP110E, ASP112E, ASP146E, ASP205F, ASP231F, ASP32E, ASP40E, ASP70E, ASP72E, ASP80E, CYS113E, CYS116E, CYS148E, CYS209F, CYS233F, CYS277F, CYS68E, GLN137E, GLN161E, GLN230F, GLN274F, GLU234F, GLU244F, GLU35E, GLY141E, GLY145E, GLY153E, GLY203F, GLY225F, GLY237F, GLY240F, GLY45E, GLY66E, GLY82E, HIS287F, HIS41E, ILE127E, ILE136E, ILE157E, ILE159E, ILE160E, ILE229F, ILE49E, LEU119E, LEU139E, LEU142E, LEU151E, LEU207F, LEU232F, LEU236F, LEU243F, LEU248F, LEU249F, LEU282F, LEU286F, LEU74E, LEU81E, LYS144E, LYS147E, LYS154E, LYS156E, LYS238F, LYS284F, LYS285F, LYS291F, LYS36E, LYS38E, MET208F, MET235F, MET281F, MET39E, PHE114E, PHE118E, PHE143E, PHE158E, PHE206F, PHE245F, PHE278F, PHE288F, PHE289F, PHE31E, PHE78E, PHE83E, PRO155E, PRO276F, PRO290F, PRO33E, SER120E, SER211F, SER226F, SER241F, SER242F, SER280F, SER292F, SER79E, THR140E, THR246F, THR283F, THR67E, THR75E, TRP227F, TYR210F, TYR228F, TYR239F, TYR37E, VAL115E, VAL117E, VAL152E, VAL212F, VAL223F, VAL252F
• E-H: ALA34E, ARG254H, ASN253H, ASP32E, GLN258H, GLU234H, GLU247H, GLU35E, LEU243H, LEU248H, LEU251H, LYS144E, LYS238H, LYS255H, LYS36E, MET235H, PHE31E, PRO33E, SER242H, SER257H, THR250H, TYR239H, TYR37E, VAL252H, VAL256H, VAL275H
• E-I: ALA109E, ARG42E, ARG43E, ASP110E, ASP40E, HIS41E, HIS58I, LYS154E, LYS38E, LYS92I, PHE56I, SER107E, TRP57I, TYR130I
• E-M: ALA109E, ALA109M, ALA111E, ARG42E, ARG42M, ARG43E, ARG43M, ASP110E, ASP110M, ASP146E, CYS148E, CYS148M, GLU102E, GLU102M, GLU94M, GLU95M, HIS101E, HIS101M, HIS108E, HIS108M, HIS149E, HIS149M, ILE46M, LEU151E, LEU97E, LEU98E, LEU98M, LYS147E, LYS147M, LYS154E, LYS86M, LYS99M, SER104E, SER104M, SER107E, SER107M, SER150E, SER150M, THR105E, THR105M, VAL103M, VAL106E, VAL106M
• F-G: ALA34G, ARG254F, ASN253F, ASP32G, GLN258F, GLU247F, GLU35G, GLY153G, LEU243F, LEU248F, LEU251F, LYS144G, LYS238F, LYS255F, LYS36G, MET235F, PRO33G, SER242F, SER257F, THR250F, TYR239F, TYR37G, VAL275F
• F-H: ALA202F, ALA202H, ALA204F, ALA204H, ALA279F, ALA279H, ARG254F, ARG254H, ASN253F, ASN253H, ASP205F, ASP205H, CYS209F, CYS277F, CYS277H, GLN258F, GLN258H, GLN274F, GLN274H, GLU244F, GLU244H, GLU247F, GLU247H, GLY203F, GLY203H, HIS287F, LEU200H, LEU207F, LEU207H, LEU243F, LEU243H, LEU248F, LEU248H, LEU249F, LEU249H, LEU251F, LEU251H, LEU282F, LEU282H, LEU286F, LEU286H, LYS255F, LYS255H, LYS284F, LYS284H, LYS285F, LYS285H, MET208F, MET208H, MET281F, MET281H, PHE206F, PHE206H, PHE278F, PHE278H, PRO201H, PRO276F, PRO276H, SER211F, SER211H, SER257F, SER257H, SER280F, SER280H, THR246F, THR246H, THR250F, THR250H, THR283F, THR283H, TYR210F, TYR210H, VAL212F, VAL212H, VAL252F, VAL252H, VAL256F, VAL256H, VAL275F, VAL275H
• G-H: ALA111G, ALA162G, ALA202H, ALA204H, ALA279H, ALA34G, ALA69G, ARG42G, ARG43G, ARG44G, ARG64G, ARG65G, ARG71G, ARG76G, ARG77G, ASN125G, ASN73G, ASP110G, ASP112G, ASP146G, ASP205H, ASP231H, ASP32G, ASP40G, ASP70G, ASP72G, ASP80G, CYS113G, CYS116G, CYS148G, CYS209H, CYS233H, CYS277H, CYS68G, GLN137G, GLN161G, GLN230H, GLN274H, GLU234H, GLU244H, GLU35G, GLY122G, GLY141G, GLY145G, GLY153G, GLY203H, GLY225H, GLY237H, GLY240H, GLY45G, GLY66G, GLY82G, HIS287H, HIS41G, ILE127G, ILE136G, ILE157G, ILE159G, ILE160G, ILE229H, ILE49G, LEU119G, LEU139G, LEU142G, LEU151G, LEU200H, LEU207H, LEU232H, LEU236H, LEU243H, LEU248H, LEU249H, LEU282H, LEU286H, LEU74G, LEU81G, LYS144G, LYS147G, LYS154G, LYS156G, LYS238H, LYS284H, LYS285H, LYS291H, LYS36G, LYS38G, MET208H, MET235H, MET281H, MET39G, PHE114G, PHE118G, PHE143G, PHE158G, PHE206H, PHE245H, PHE278H, PHE288H, PHE289H, PHE78G, PHE83G, PRO155G, PRO201H, PRO276H, PRO290H, PRO33G, SER211H, SER226H, SER241H, SER242H, SER280H, SER79G, THR138G, THR140G, THR246H, THR283H, THR67G, THR75G, TRP227H, TYR210H, TYR228H, TYR239H, TYR37G, VAL115G, VAL117G, VAL152G, VAL212H
• I-J: ALA111I, ALA162I, ALA202J, ALA204J, ALA279J, ALA34I, ALA69I, ARG42I, ARG43I, ARG44I, ARG64I, ARG65I, ARG71I, ARG76I, ARG77I, ASN125I, ASN224J, ASN51I, ASN73I, ASP110I, ASP112I, ASP146I, ASP205J, ASP231J, ASP32I, ASP40I, ASP70I, ASP72I, ASP80I, CYS113I, CYS116I, CYS148I, CYS163I, CYS209J, CYS233J, CYS277J, CYS68I, GLN137I, GLN161I, GLN230J, GLN274J, GLU234J, GLU244J, GLU35I, GLY124I, GLY141I, GLY145I, GLY153I, GLY203J, GLY225J, GLY237J, GLY240J, GLY45I, GLY66I, GLY82I, HIS287J, HIS41I, ILE127I, ILE136I, ILE157I, ILE159I, ILE160I, ILE229J, ILE49I, LEU119I, LEU139I, LEU142I, LEU151I, LEU207J, LEU232J, LEU236J, LEU248J, LEU249J, LEU282J, LEU286J, LEU74I, LEU81I, LYS144I, LYS147I, LYS154I, LYS156I, LYS238J, LYS284J, LYS285J, LYS291J, LYS36I, LYS38I, MET208J, MET235J, MET281J, MET39I, PHE114I, PHE118I, PHE143I, PHE158I, PHE206J, PHE245J, PHE278J, PHE288J, PHE289J, PHE31I, PHE78I, PHE83I, PRO155I, PRO201J, PRO276J, PRO290J, PRO33I, SER211J, SER226J, SER241J, SER242J, SER280J, SER292J, SER79I, THR140I, THR222J, THR246J, THR283J, THR67I, THR75I, TRP227J, TYR210J, TYR228J, TYR239J, TYR37I, VAL115I, VAL117I, VAL152I, VAL212J, VAL223J, VAL252J
• I-L: ALA34I, ARG254L, ASN253L, ASP32I, GLN258L, GLU247L, GLU35I, LEU243L, LEU248L, LEU251L, LYS144I, LYS238L, LYS255L, LYS36I, MET235L, PHE31I, PRO33I, SER242L, SER257L, THR250L, TYR239L, TYR37I, VAL252L, VAL256L, VAL275L
• I-M: ALA129I, ALA129M, ALA132I, ALA132M, ALA93I, ALA93M, ASN125I, ASN125M, ASP131I, ASP131M, GLN137I, GLU102I, GLU102M, GLU123I, GLU123M, GLU135I, GLU135M, GLU94I, GLU94M, GLU95I, GLU95M, GLY124I, GLY124M, HIS101I, HIS101M, HIS126I, HIS126M, HIS58I, HIS58M, ILE100I, ILE100M, ILE127M, ILE134I, ILE134M, ILE136I, ILE136M, LEU139I, LEU139M, LEU142I, LEU142M, LEU59I, LEU59M, LEU96I, LEU96M, LEU97I, LEU97M, LEU98I, LEU98M, LYS133I, LYS133M, LYS147I, LYS147M, LYS92I, LYS92M, LYS99I, LYS99M, PHE56I, PHE56M, SER104I, THR105I, THR105M, THR138I, THR138M, THR60I, THR60M, TRP57I, TRP57M, TYR128I, TYR128M, TYR130I, TYR130M
• J-K: ALA34K, ARG254J, ASN253J, ASP32K, GLN258J, GLU234J, GLU247J, GLU35K, GLY153K, LEU243J, LEU248J, LEU251J, LYS144K, LYS238J, LYS255J, LYS36K, MET235J, PHE31K, PRO33K, SER242J, SER257J, THR250J, TYR239J, TYR37K, VAL252J, VAL256J, VAL275J
• J-L: ALA202J, ALA202L, ALA204J, ALA204L, ALA279J, ALA279L, ARG254J, ARG254L, ASN253J, ASN253L, ASP205J, ASP205L, CYS209J, CYS209L, CYS277J, CYS277L, GLN258J, GLN258L, GLN274J, GLN274L, GLU244J, GLU244L, GLU247J, GLU247L, GLY203J, GLY203L, HIS287J, LEU207J, LEU207L, LEU243J, LEU243L, LEU248J, LEU248L, LEU249J, LEU249L, LEU251J, LEU251L, LEU282J, LEU282L, LEU286J, LEU286L, LYS255J, LYS255L, LYS273J, LYS284J, LYS284L, LYS285J, LYS285L, MET208J, MET208L, MET281J, MET281L, PHE206J, PHE206L, PHE278J, PHE278L, PRO201J, PRO276J, PRO276L, SER211J, SER257J, SER257L, SER280J, SER280L, THR246J, THR246L, THR250J, THR250L, THR283J, THR283L, TYR210J, TYR210L, VAL212J, VAL212L, VAL252J, VAL252L, VAL256J, VAL256L, VAL275J, VAL275L
• K-L: ALA111K, ALA162K, ALA202L, ALA204L, ALA279L, ALA34K, ALA69K, ARG42K, ARG43K, ARG44K, ARG64K, ARG65K, ARG71K, ARG76K, ARG77K, ASN125K, ASN224L, ASN73K, ASP110K, ASP112K, ASP146K, ASP205L, ASP231L, ASP32K, ASP40K, ASP70K, ASP72K, ASP80K, CYS113K, CYS116K, CYS148K, CYS163K, CYS209L, CYS233L, CYS277L, CYS68K, GLN137K, GLN161K, GLN230L, GLU234L, GLU244L, GLU35K, GLY141K, GLY145K, GLY153K, GLY203L, GLY225L, GLY237L, GLY240L, GLY45K, GLY66K, GLY82K, HIS287L, HIS41K, ILE127K, ILE136K, ILE157K, ILE159K, ILE160K, ILE229L, ILE49K, LEU119K, LEU139K, LEU142K, LEU151K, LEU207L, LEU232L, LEU236L, LEU243L, LEU248L, LEU249L, LEU282L, LEU286L, LEU74K, LEU81K, LYS144K, LYS147K, LYS154K, LYS156K, LYS238L, LYS284L, LYS285L, LYS291L, LYS36K, LYS38K, MET208L, MET235L, MET281L, MET39K, PHE114K, PHE118K, PHE143K, PHE158K, PHE206L, PHE245L, PHE278L, PHE288L, PHE289L, PHE31K, PHE78K, PHE83K, PRO155K, PRO276L, PRO290L, PRO33K, SER211L, SER226L, SER241L, SER242L, SER280L, SER79K, THR138K, THR140K, THR246L, THR283L, THR67K, THR75K, TRP227L, TYR210L, TYR228L, TYR239L, TYR37K, VAL115K, VAL117K, VAL152K, VAL212L, VAL256L
• K-O: ALA129K, ALA129O, ALA132K, ALA132O, ALA93K, ALA93O, ASN125K, ASN125O, ASP131K, ASP131O, GLN137O, GLU102K, GLU102O, GLU123K, GLU123O, GLU135K, GLU135O, GLU94K, GLU94O, GLU95K, GLU95O, GLY124K, HIS101K, HIS101O, HIS126K, HIS126O, HIS58K, HIS58O, ILE100K, ILE100O, ILE134K, ILE134O, ILE136K, ILE136O, LEU139K, LEU139O, LEU142K, LEU142O, LEU59K, LEU59O, LEU96K, LEU96O, LEU97K, LEU97O, LEU98K, LEU98O, LYS133K, LYS133O, LYS147K, LYS147O, LYS92K, LYS92O, LYS99K, LYS99O, PHE56K, PHE56O, SER104K, THR105K, THR105O, THR138K, THR138O, THR60K, THR60O, TRP57K, TRP57O, TYR128K, TYR128O, TYR130K, TYR130O
• M-N: ALA111M, ALA162M, ALA202N, ALA204N, ALA279N, ALA34M, ALA69M, ARG42M, ARG43M, ARG44M, ARG64M, ARG65M, ARG71M, ARG76M, ARG77M, ASN125M, ASN224N, ASN73M, ASP110M, ASP112M, ASP146M, ASP205N, ASP231N, ASP32M, ASP40M, ASP70M, ASP72M, ASP80M, CYS113M, CYS116M, CYS148M, CYS163M, CYS209N, CYS233N, CYS277N, CYS68M, GLN137M, GLN161M, GLN230N, GLU234N, GLU244N, GLU35M, GLU53M, GLU63M, GLY141M, GLY145M, GLY153M, GLY203N, GLY225N, GLY237N, GLY240N, GLY45M, GLY66M, GLY82M, HIS287N, HIS41M, ILE136M, ILE157M, ILE159M, ILE160M, ILE229N, ILE49M, LEU119M, LEU139M, LEU142M, LEU151M, LEU207N, LEU232N, LEU236N, LEU243N, LEU248N, LEU249N, LEU282N, LEU286N, LEU74M, LEU81M, LYS144M, LYS147M, LYS154M, LYS156M, LYS238N, LYS284N, LYS285N, LYS291N, LYS36M, LYS38M, MET208N, MET235N, MET281N, MET39M, PHE114M, PHE118M, PHE143M, PHE158M, PHE206N, PHE245N, PHE278N, PHE288N, PHE289N, PHE31M, PHE78M, PHE83M, PRO155M, PRO276N, PRO290N, PRO33M, SER211N, SER226N, SER241N, SER242N, SER280N, SER292N, THR140M, THR222N, THR246N, THR283N, THR67M, THR75M, TRP227N, TYR210N, TYR228N, TYR239N, TYR37M, VAL115M, VAL117M, VAL152M, VAL212N, VAL223N, VAL252N
• M-O: ASN125M, ASN125O
• M-P: ALA34M, ARG254P, ASN253P, ASP32M, GLN258P, GLU247P, GLU35M, LEU243P, LEU248P, LEU251P, LYS144M, LYS238P, LYS255P, LYS36M, MET235P, PHE31M, PRO33M, SER242P, THR250P, TYR239P, TYR37M, VAL252P, VAL256P, VAL275P
• N-O: ALA34O, ARG254N, ASN253N, ASP231N, ASP32O, GLN258N, GLU234N, GLU247N, GLU35O, LEU243N, LEU248N, LEU251N, LYS144O, LYS238N, LYS255N, LYS36O, MET235N, PHE31O, PRO33O, THR250N, TYR239N, TYR37O, VAL252N, VAL256N, VAL275N
• N-P: ALA202N, ALA202P, ALA204N, ALA204P, ALA279N, ALA279P, ARG254N, ARG254P, ASN253N, ASN253P, ASP205N, ASP205P, CYS209N, CYS277N, CYS277P, GLN258N, GLN258P, GLN274P, GLU244N, GLU244P, GLU247N, GLU247P, GLY203N, GLY203P, HIS287N, LEU207N, LEU207P, LEU243N, LEU243P, LEU248N, LEU248P, LEU249N, LEU249P, LEU251N, LEU251P, LEU282N, LEU282P, LEU286N, LEU286P, LYS255N, LYS255P, LYS284N, LYS284P, LYS285N, LYS285P, MET208N, MET208P, MET281N, MET281P, PHE206N, PHE206P, PHE278N, PHE278P, PRO201P, PRO276N, PRO276P, SER211N, SER211P, SER257N, SER257P, SER280N, SER280P, THR246N, THR246P, THR250N, THR250P, THR283N, THR283P, TYR210N, TYR210P, VAL212N, VAL212P, VAL252N, VAL252P, VAL256N, VAL256P, VAL275N, VAL275P
• O-P: ALA111O, ALA162O, ALA202P, ALA204P, ALA279P, ALA34O, ALA69O, ARG42O, ARG43O, ARG44O, ARG64O, ARG65O, ARG71O, ARG76O, ARG77O, ASN125O, ASN224P, ASN51O, ASN73O, ASP110O, ASP112O, ASP205P, ASP231P, ASP32O, ASP40O, ASP70O, ASP72O, ASP80O, CYS113O, CYS116O, CYS148O, CYS209P, CYS233P, CYS277P, CYS68O, GLN137O, GLN161O, GLN230P, GLN274P, GLU234P, GLU244P, GLU35O, GLY124O, GLY141O, GLY145O, GLY153O, GLY203P, GLY225P, GLY237P, GLY240P, GLY45O, GLY66O, GLY82O, HIS287P, HIS41O, ILE127O, ILE136O, ILE157O, ILE159O, ILE160O, ILE229P, ILE49O, LEU119O, LEU139O, LEU142O, LEU151O, LEU207P, LEU232P, LEU236P, LEU248P, LEU249P, LEU282P, LEU286P, LEU74O, LEU81O, LYS144O, LYS147O, LYS154O, LYS156O, LYS238P, LYS284P, LYS285P, LYS291P, LYS36O, LYS38O, MET208P, MET235P, MET281P, MET39O, PHE114O, PHE118O, PHE143O, PHE158O, PHE206P, PHE245P, PHE278P, PHE288P, PHE289P, PHE31O, PHE78O, PHE83O, PRO155O, PRO201P, PRO276P, PRO290P, PRO33O, SER211P, SER226P, SER241P, SER242P, SER280P, SER292P, THR140O, THR246P, THR283P, THR67O, THR75O, TRP227P, TYR210P, TYR228P, TYR239P, TYR37O, VAL115O, VAL117O, VAL152O, VAL212P