3P11

anti-egfr/her3 fab dl11 in complex with domains i-iii of the her3 extracellular region

• Total interactions analyzed: 3
• Total true interactions: 3
• Strongest Interaction:
  • Chains: H-A
  • Int. Res.: 69
  • Norm. En. per Res.: -3.6191
• Hub Node: H(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
H-L	-10.9835	38.0304	-422.865	-395.8181	191	15	15	17730	0	21	27
H-A	-43.2088	-68.6643	-137.845	-249.7181	69	17	3	6443	7	29	19
L-A	-14.0505	-19.6297	-40.3506	-74.0309	28	8	0	1952	4	22	6

Interface residues

• H-L: ALA100H, ALA125H, ALA130L, ALA136H, ALA137H, ALA168H, ALA30L, ALA34L, ALA40H, ALA43L, ALA51L, ALA60H, ALA93H, ARG142L, ARG38H, ARG94H, ARG97H, ASN137L, ASN138L, ASN158L, ASN210L, ASP101H, ASP122L, ASP144H, ASP167L, ASP170L, ASP1L, ASP32L, ASP58H, ASP61H, CYS134L, CYS140H, CYS88L, CYS92H, GLN100L, GLN105H, GLN124L, GLN160L, GLN171H, GLN37L, GLN38L, GLN39H, GLN89L, GLN90L, GLU100H, GLU123L, GLU161L, GLU165L, GLU46H, GLU50H, GLU6H, GLU92L, GLU94L, GLU95H, GLY101L, GLY104H, GLY106H, GLY128L, GLY139H, GLY157L, GLY162H, GLY174H, GLY41L, GLY42H, GLY44H, GLY49H, GLY99L, HIS164H, HIS35H, ILE117L, ILE48L, LEU124H, LEU125L, LEU135L, LEU136L, LEU138H, LEU141H, LEU170H, LEU175H, LEU175L, LEU178H, LEU179L, LEU181L, LEU29L, LEU45H, LEU46L, LEU47L, LEU48H, LEU4H, LEU54L, LYS126L, LYS143H, LYS169L, LYS207L, LYS209H, LYS210H, LYS214H, LYS39L, LYS42L, LYS43H, LYS45L, LYS64H, MET100H, PHE100H, PHE116L, PHE118L, PHE122H, PHE139L, PHE166H, PHE209L, PHE53L, PHE98L, PRO119L, PRO120L, PRO123H, PRO126H, PRO167H, PRO40L, PRO44L, PRO93L, PRO95L, SER114L, SER120H, SER121L, SER127H, SER127L, SER128H, SER131L, SER159L, SER161H, SER162L, SER172H, SER173H, SER174L, SER176L, SER177H, SER177L, SER179H, SER180H, SER186H, SER208L, SER50L, SER52L, SER56L, SER62H, SER91L, SER96H, SER99H, THR129L, THR135H, THR164L, THR165H, THR172L, THR178L, THR180L, THR183H, THR31L, THR57H, THR85L, THR97L, TRP103H, TRP33H, TRP35L, TRP36H, TRP47H, TYR102H, TYR173L, TYR176H, TYR36L, TYR49L, TYR55L, TYR56H, TYR59H, TYR87L, TYR91H, TYR96L, VAL115L, VAL121H, VAL132L, VAL133L, VAL163H, VAL163L, VAL169H, VAL181H, VAL182H, VAL184H, VAL211H, VAL33L, VAL37H, VAL89H, VAL98H
• H-A: ALA100H, ALA439A, ALA52H, ALA53H, ARG407A, ARG434A, ARG441A, ARG462A, ARG469A, ARG471A, ARG472A, ARG94H, ARG97H, ASN379A, ASN406A, ASN440A, ASN468A, ASN76H, ASP32H, ASP464A, ASP473A, ASP58H, GLN381A, GLU100H, GLU460A, GLU461A, GLU50H, GLU95H, GLY31H, GLY408A, GLY54H, GLY55H, HIS35H, HIS446A, HIS447A, HIS467A, ILE34H, ILE435A, ILE437A, ILE465A, ILE51H, LEU29H, LEU412A, LEU417A, LEU463A, LYS415A, LYS466A, LYS64H, MET100H, MET414A, PHE100H, PHE27H, PHE409A, PRO470A, SER30H, SER438A, SER52H, SER74H, SER96H, SER99H, THR28H, THR459A, THR57H, THR73H, TRP33H, TRP47H, TYR405A, TYR436A, TYR56H
• L-A: ALA30L, ALA439A, ALA476A, ARG441A, ARG469A, ARG471A, ARG472A, ASN468A, ASP28L, ASP32L, ASP473A, GLN89L, GLU92L, GLU94L, GLY68L, HIS467A, LEU29L, LYS466A, PRO470A, PRO93L, PRO95L, SER50L, SER67L, SER91L, THR31L, TYR96L, VAL33L, VAL475A