3OW1

crystal structure of d-mannonate dehydratase from chromohalobacter salexigens complexed with mg

• Total interactions analyzed: 28
• Total true interactions: 20
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 222
  • Norm. En. per Res.: -4.3323
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-86.2251	-143.1682	-719.818	-949.2113	225	27	23	27629	17	68	94
A-C	-86.7484	5.7707	-312.781	-393.7587	127	25	2	14096	3	37	49
A-D	-77.98	-40.0855	-226.426	-344.4914	111	12	0	9484	3	55	56
A-F	0.0	4.7385	0.0	4.7385	2	0	0	0	0	6	2
A-G	-64.5052	-29.1002	-219.358	-312.9635	110	10	0	9246	4	53	57
B-C	-60.0217	-41.6227	-222.307	-323.9514	111	12	0	9303	4	55	59
B-E	0.0	4.9396	0.0	4.9396	2	0	0	0	0	6	2
B-G	-79.8384	7.5632	-316.521	-388.7962	129	20	2	13834	4	37	49
B-H	-73.9183	-40.4708	-231.079	-345.4681	112	13	0	9417	4	56	57
C-D	-82.3234	-146.4145	-733.027	-961.7649	222	26	23	28014	19	69	95
C-E	-62.9048	-36.1192	-227.117	-326.141	111	13	0	9388	4	56	56
C-H	0.0	5.0061	0.0	5.0061	2	0	0	0	0	6	2
D-E	-89.0526	-1.7379	-327.727	-418.5175	130	24	2	14247	4	38	49
D-F	-69.173	-28.7295	-225.967	-323.8694	110	13	0	9397	4	54	58
D-G	0.0	5.1941	0.0	5.1941	2	0	0	0	0	6	2
E-F	-78.9071	-148.4887	-712.524	-939.9199	222	28	23	27857	18	68	96
E-H	-66.8137	-26.6723	-223.615	-317.1011	111	10	0	9289	3	54	57
F-G	-74.5867	-27.9396	-231.687	-334.2133	111	14	0	9486	3	55	57
F-H	-80.2736	0.1558	-331.363	-411.4809	126	22	3	14189	4	36	49
G-H	-77.1396	-155.9384	-719.133	-952.211	221	21	22	27748	18	68	95

Interface residues

• A-B: ALA174B, ALA180A, ALA180B, ALA244A, ALA244B, ALA390A, ALA390B, ALA44A, ALA44B, ALA46A, ALA46B, ALA47A, ALA47B, ALA56A, ALA56B, ALA76A, ALA76B, ALA87A, ALA87B, ARG149A, ARG17A, ARG17B, ARG217A, ARG217B, ARG274A, ARG274B, ARG286A, ARG286B, ARG389A, ARG389B, ARG396A, ARG396B, ARG41A, ARG41B, ARG60A, ARG60B, ARG64A, ARG64B, ARG74A, ARG74B, ARG79A, ARG79B, ARG80A, ARG80B, ASN18A, ASN18B, ASN246A, ASN246B, ASN268A, ASN268B, ASN279A, ASN279B, ASN395A, ASN395B, ASN39A, ASN39B, ASP213A, ASP213B, ASP240A, ASP240B, ASP272A, ASP272B, ASP319A, ASP319B, ASP399A, ASP399B, ASP50A, ASP50B, ASP61A, ASP61B, ASP67A, ASP67B, CYS273A, CYS273B, GLN247A, GLN247B, GLN278A, GLN278B, GLN70A, GLN70B, GLU181A, GLU181B, GLU239A, GLU239B, GLU245A, GLU245B, GLU248A, GLU248B, GLU265A, GLU265B, GLU275A, GLU275B, GLU388A, GLU388B, GLU42A, GLU42B, GLU51A, GLU51B, GLU66A, GLU66B, GLY264A, GLY264B, GLY400A, GLY400B, GLY40A, GLY40B, GLY75A, GLY75B, GLY81A, GLY81B, HIS215A, HIS215B, HIS216A, HIS216B, HIS271A, HIS271B, HIS291A, HIS291B, HIS315A, HIS315B, HIS404A, HIS404B, HIS52A, HIS52B, ILE263B, ILE270A, ILE270B, ILE58A, ILE58B, ILE88A, ILE88B, LEU178A, LEU178B, LEU320A, LEU320B, LEU38A, LEU38B, LEU392A, LEU392B, LEU397A, LEU397B, LEU402A, LEU402B, LEU49A, LEU49B, LEU57A, LEU57B, LEU72A, LEU72B, MET287A, MET287B, MET43A, MET43B, MET85A, MET85B, PHE267A, PHE267B, PRO179A, PRO179B, PRO243A, PRO243B, PRO288A, PRO288B, PRO317A, PRO317B, PRO393A, PRO393B, PRO55A, PRO55B, PRO82A, PRO82B, SER177A, SER177B, SER249A, SER249B, SER269A, SER269B, SER391A, SER391B, THR37A, THR37B, THR401A, THR401B, THR68A, THR68B, THR84A, THR84B, THR86A, THR86B, TRP281A, TRP281B, TRP403A, TRP403B, TRP405A, TRP405B, TRP69A, TRP69B, TRP78A, TRP78B, TYR387A, TYR387B, TYR48A, TYR48B, TYR71A, TYR71B, TYR73A, TYR73B, TYR77A, TYR77B, VAL20A, VAL20B, VAL242A, VAL242B, VAL266A, VAL266B, VAL394A, VAL394B, VAL45A, VAL45B, VAL53A, VAL53B, VAL54A, VAL54B, VAL83A, VAL83B
• A-C: ALA100A, ALA100C, ALA102A, ALA102C, ALA103A, ALA103C, ALA302A, ALA302C, ALA62A, ALA62C, ARG116A, ARG116C, ARG118A, ARG118C, ARG274A, ARG274C, ARG299A, ARG299C, ARG300A, ARG300C, ARG60A, ARG60C, ARG64A, ARG64C, ARG74A, ARG74C, ARG79A, ARG79C, ASN279A, ASN279C, ASN337A, ASN337C, ASP303A, ASP303C, ASP61A, ASP61C, ASP67A, ASP67C, GLN109A, GLN109C, GLN278A, GLN278C, GLN280A, GLN280C, GLN70A, GLN70C, GLU117A, GLU117C, GLU275A, GLU275C, GLU66A, GLU66C, GLY104A, GLY104C, GLY112A, GLY112C, GLY113A, GLY113C, GLY63A, GLY63C, HIS271A, HIS271C, HIS309A, HIS309C, ILE270A, ILE270C, ILE277A, ILE277C, ILE295A, ILE295C, ILE65A, ILE65C, ILE98A, ILE98C, LEU107A, LEU107C, LEU110A, LEU110C, LEU111A, LEU111C, LEU304A, LEU304C, LEU307A, LEU307C, LEU3A, LEU3C, LEU95A, LEU95C, LYS101A, LYS101C, LYS114A, LYS114C, LYS99A, LYS99C, MET105A, MET105C, PHE338A, PRO106A, PRO106C, PRO336A, PRO336C, SER115A, SER115C, SER269A, SER269C, SER306A, SER306C, THR296A, THR296C, THR333A, THR333C, THR68A, THR68C, TRP334A, TRP334C, TRP69A, TRP69C, TRP96A, TRP96C, TYR108A, TYR108C, TYR308A, TYR308C, VAL301A, VAL301C, VAL335A, VAL335C
• A-D: ALA223D, ALA224D, ALA229D, ALA244D, ARG116A, ARG118A, ARG146A, ARG201A, ARG217D, ARG225D, ARG251A, ARG251D, ARG254A, ARG311A, ARG396D, ASN191D, ASN246D, ASN279A, ASN337A, ASP206A, ASP207A, ASP283A, ASP332A, ASP399D, GLN247D, GLN278A, GLN280A, GLU117A, GLU187D, GLU222D, GLU231A, GLU245D, GLU248D, GLU255A, GLU255D, GLU398D, GLY156D, GLY205A, GLY227A, GLY227D, GLY339A, GLY400D, HIS192D, HIS209A, HIS216D, HIS234A, HIS256A, HIS256D, HIS309A, HIS364A, HIS404D, ILE221D, ILE253A, ILE253D, ILE277A, ILE282A, LEU190D, LEU208A, LEU218D, LEU226D, LEU235A, LEU250D, LEU252A, LEU252D, LEU261A, LEU304A, LEU307A, LEU397D, LEU402D, LYS114A, LYS188D, LYS195D, LYS228A, LYS228D, MET120A, PHE236A, PHE338A, PRO155D, PRO194D, PRO220D, PRO232A, PRO243D, PRO260A, PRO336A, SER115A, SER185D, SER249D, SER306A, THR186D, THR219D, THR257A, THR257D, THR258A, THR259A, THR333A, THR401D, TRP184D, TRP237A, TRP281A, TRP281D, TRP334A, TRP403D, TYR233A, TYR284A, TYR308A, VAL119A, VAL183D, VAL210A, VAL242D, VAL310A, VAL335A
• A-F: GLU255A, GLU255F
• A-G: ALA223A, ALA224A, ALA229A, ALA244A, ARG116G, ARG118G, ARG146G, ARG201G, ARG217A, ARG225A, ARG251A, ARG251G, ARG254G, ARG311G, ARG396A, ASN191A, ASN246A, ASN279G, ASN337G, ASP206G, ASP207G, ASP283G, ASP332G, ASP399A, GLN247A, GLN278G, GLN280G, GLU117G, GLU187A, GLU222A, GLU231G, GLU245A, GLU248A, GLU255A, GLU255G, GLU398A, GLY156A, GLY205G, GLY227A, GLY227G, GLY339G, GLY400A, HIS192A, HIS209G, HIS216A, HIS234G, HIS256A, HIS256G, HIS309G, HIS364G, HIS404A, ILE221A, ILE253A, ILE253G, ILE277G, ILE282G, LEU190A, LEU208G, LEU218A, LEU226A, LEU235G, LEU250A, LEU252A, LEU252G, LEU261G, LEU276G, LEU304G, LEU307G, LEU397A, LEU402A, LYS114G, LYS188A, LYS195A, LYS228A, LYS228G, MET120G, PHE236G, PHE338G, PRO155A, PRO194A, PRO220A, PRO232G, PRO243A, PRO260G, PRO336G, SER115G, SER185A, SER249A, SER306G, THR186A, THR219A, THR257A, THR257G, THR258G, THR259G, THR401A, TRP184A, TRP237G, TRP281A, TRP281G, TRP334G, TRP403A, TYR233G, TYR284G, TYR308G, VAL119G, VAL210G, VAL242A, VAL310G, VAL335G
• B-C: ALA223B, ALA224B, ALA229B, ALA244B, ARG116C, ARG118C, ARG146C, ARG201C, ARG217B, ARG225B, ARG251B, ARG251C, ARG254C, ARG311C, ARG396B, ASN191B, ASN246B, ASN279C, ASN337C, ASP206C, ASP207C, ASP283C, ASP332C, ASP399B, GLN247B, GLN278C, GLN280C, GLU117C, GLU187B, GLU222B, GLU231C, GLU245B, GLU248B, GLU255B, GLU255C, GLU398B, GLY156B, GLY205C, GLY227B, GLY227C, GLY339C, GLY400B, HIS192B, HIS209C, HIS216B, HIS234C, HIS256B, HIS256C, HIS309C, HIS364C, HIS404B, ILE221B, ILE253B, ILE253C, ILE277C, ILE282C, ILE340C, LEU190B, LEU208C, LEU218B, LEU226B, LEU235C, LEU250B, LEU252B, LEU252C, LEU261C, LEU304C, LEU307C, LEU397B, LEU402B, LYS114C, LYS188B, LYS195B, LYS228B, LYS228C, MET120C, PHE236C, PHE338C, PRO155B, PRO194B, PRO220B, PRO232C, PRO243B, PRO260C, PRO336C, SER115C, SER185B, SER249B, SER306C, THR186B, THR219B, THR257B, THR257C, THR258C, THR259C, THR333C, THR401B, TRP237C, TRP281B, TRP281C, TRP334C, TRP403B, TYR233C, TYR284C, TYR308C, VAL119C, VAL183B, VAL210C, VAL242B, VAL310C, VAL335C
• B-E: GLU255B, GLU255E
• B-G: ALA100B, ALA100G, ALA102B, ALA102G, ALA103B, ALA103G, ALA302B, ALA302G, ALA305G, ALA62B, ALA62G, ARG116B, ARG116G, ARG118B, ARG118G, ARG274B, ARG274G, ARG299B, ARG299G, ARG300B, ARG300G, ARG311G, ARG60B, ARG60G, ARG64B, ARG64G, ARG74B, ARG74G, ARG79B, ARG79G, ASN279B, ASN279G, ASN337B, ASN337G, ASP303B, ASP303G, ASP61B, ASP61G, ASP67B, ASP67G, GLN109B, GLN109G, GLN278B, GLN278G, GLN280B, GLN280G, GLN70B, GLN70G, GLU117B, GLU117G, GLU275B, GLU275G, GLU66B, GLU66G, GLY104B, GLY104G, GLY112B, GLY112G, GLY113B, GLY113G, GLY63B, GLY63G, HIS271B, HIS271G, HIS309B, HIS309G, ILE270B, ILE270G, ILE277B, ILE277G, ILE295B, ILE295G, ILE65B, ILE65G, ILE98B, ILE98G, LEU107B, LEU107G, LEU110B, LEU110G, LEU111B, LEU111G, LEU304B, LEU304G, LEU307B, LEU307G, LEU3B, LEU3G, LEU95B, LEU95G, LYS101B, LYS101G, LYS114B, LYS114G, LYS99B, LYS99G, MET105B, MET105G, PHE338G, PRO106B, PRO106G, PRO336B, PRO336G, SER115B, SER115G, SER269G, SER306B, SER306G, THR296B, THR296G, THR333B, THR333G, THR68B, THR68G, TRP334B, TRP334G, TRP69B, TRP69G, TRP96B, TRP96G, TYR108B, TYR108G, TYR308B, TYR308G, TYR73G, VAL301B, VAL301G, VAL335B, VAL335G
• B-H: ALA223H, ALA224H, ALA229H, ALA244H, ARG116B, ARG118B, ARG146B, ARG201B, ARG217H, ARG225H, ARG251B, ARG251H, ARG254B, ARG311B, ARG396H, ASN191H, ASN246H, ASN279B, ASN337B, ASP206B, ASP207B, ASP283B, ASP332B, ASP399H, GLN247H, GLN278B, GLN280B, GLU117B, GLU187H, GLU222H, GLU231B, GLU245H, GLU248H, GLU255B, GLU255H, GLU398H, GLY156H, GLY205B, GLY227B, GLY227H, GLY339B, GLY400H, HIS192H, HIS209B, HIS216H, HIS234B, HIS256B, HIS256H, HIS309B, HIS364B, HIS404H, ILE221H, ILE253B, ILE253H, ILE277B, ILE282B, LEU190H, LEU208B, LEU218H, LEU226H, LEU235B, LEU250H, LEU252B, LEU252H, LEU261B, LEU276B, LEU304B, LEU307B, LEU397H, LEU402H, LYS114B, LYS188H, LYS195H, LYS228B, LYS228H, MET120B, PHE236B, PHE338B, PRO155H, PRO194H, PRO220H, PRO232B, PRO243H, PRO260B, PRO336B, SER115B, SER185H, SER249H, SER306B, THR186H, THR219H, THR257B, THR257H, THR258B, THR259B, THR333B, THR401H, TRP184H, TRP237B, TRP281B, TRP281H, TRP334B, TRP403H, TYR233B, TYR284B, TYR308B, VAL119B, VAL183H, VAL210B, VAL242H, VAL310B, VAL335B
• C-D: ALA180C, ALA180D, ALA244C, ALA244D, ALA390C, ALA390D, ALA44C, ALA44D, ALA46C, ALA46D, ALA47C, ALA47D, ALA56C, ALA56D, ALA76C, ALA76D, ALA87C, ALA87D, ARG149D, ARG17C, ARG17D, ARG217C, ARG217D, ARG274C, ARG274D, ARG389C, ARG389D, ARG396C, ARG396D, ARG41C, ARG41D, ARG60C, ARG60D, ARG64C, ARG64D, ARG74C, ARG74D, ARG79C, ARG79D, ARG80C, ARG80D, ASN18C, ASN18D, ASN246C, ASN246D, ASN268C, ASN268D, ASN279C, ASN279D, ASN395C, ASN395D, ASN39C, ASN39D, ASP213C, ASP213D, ASP240C, ASP240D, ASP272C, ASP272D, ASP319C, ASP319D, ASP399C, ASP399D, ASP50C, ASP50D, ASP61C, ASP61D, ASP67C, ASP67D, CYS273C, CYS273D, GLN247C, GLN247D, GLN278C, GLN278D, GLN70C, GLN70D, GLU181C, GLU181D, GLU239C, GLU239D, GLU245C, GLU245D, GLU248C, GLU248D, GLU265C, GLU265D, GLU275C, GLU275D, GLU388C, GLU388D, GLU42C, GLU42D, GLU51C, GLU51D, GLU66C, GLU66D, GLY264C, GLY264D, GLY400C, GLY400D, GLY40C, GLY40D, GLY75C, GLY75D, GLY81C, GLY81D, HIS215C, HIS215D, HIS216C, HIS216D, HIS271C, HIS271D, HIS291C, HIS291D, HIS315C, HIS315D, HIS404C, HIS404D, HIS52C, HIS52D, ILE270C, ILE270D, ILE58C, ILE58D, ILE88C, ILE88D, LEU178C, LEU178D, LEU320C, LEU320D, LEU38C, LEU38D, LEU392C, LEU392D, LEU397C, LEU397D, LEU402C, LEU402D, LEU49C, LEU49D, LEU57C, LEU57D, LEU72C, LEU72D, MET287C, MET287D, MET43C, MET43D, MET85C, MET85D, PHE267C, PHE267D, PRO173D, PRO179C, PRO179D, PRO243C, PRO243D, PRO288C, PRO288D, PRO317C, PRO317D, PRO393C, PRO393D, PRO55C, PRO55D, PRO82C, PRO82D, SER177C, SER177D, SER249C, SER249D, SER269C, SER269D, SER391C, SER391D, THR37C, THR37D, THR401C, THR401D, THR68C, THR68D, THR84C, THR84D, THR86C, THR86D, TRP281C, TRP281D, TRP403C, TRP403D, TRP405C, TRP405D, TRP69C, TRP69D, TRP78C, TRP78D, TYR387C, TYR387D, TYR48C, TYR48D, TYR71C, TYR71D, TYR73C, TYR73D, TYR77C, TYR77D, VAL20C, VAL20D, VAL242C, VAL242D, VAL266C, VAL266D, VAL394C, VAL394D, VAL45C, VAL45D, VAL53C, VAL53D, VAL54C, VAL54D, VAL83C, VAL83D
• C-E: ALA223C, ALA224C, ALA229C, ALA244C, ARG116E, ARG118E, ARG146E, ARG201E, ARG217C, ARG225C, ARG251C, ARG251E, ARG254E, ARG311E, ARG396C, ASN191C, ASN246C, ASN279E, ASN337E, ASP206E, ASP207E, ASP283E, ASP332E, ASP399C, GLN247C, GLN278E, GLN280E, GLU117E, GLU187C, GLU222C, GLU231E, GLU245C, GLU248C, GLU255C, GLU255E, GLU398C, GLY156C, GLY205E, GLY227C, GLY227E, GLY339E, GLY400C, HIS192C, HIS209E, HIS216C, HIS234E, HIS256C, HIS256E, HIS309E, HIS364E, HIS404C, ILE221C, ILE253C, ILE253E, ILE277E, ILE282E, LEU190C, LEU208E, LEU218C, LEU226C, LEU235E, LEU250C, LEU252C, LEU252E, LEU261E, LEU276E, LEU304E, LEU307E, LEU397C, LEU402C, LYS114E, LYS188C, LYS195C, LYS228C, LYS228E, MET120E, PHE236E, PHE338E, PRO155C, PRO194C, PRO220C, PRO232E, PRO243C, PRO260E, PRO336E, SER115E, SER185C, SER249C, SER306E, THR186C, THR219C, THR257C, THR257E, THR258E, THR259E, THR333E, THR401C, TRP184C, TRP237E, TRP281C, TRP281E, TRP334E, TRP403C, TYR233E, TYR284E, TYR308E, VAL119E, VAL210E, VAL242C, VAL310E, VAL335E
• C-H: GLU255C, GLU255H
• D-E: ALA100D, ALA100E, ALA102D, ALA102E, ALA103D, ALA103E, ALA302D, ALA302E, ALA62D, ALA62E, ARG116D, ARG116E, ARG118D, ARG118E, ARG274D, ARG274E, ARG299D, ARG299E, ARG300D, ARG300E, ARG60D, ARG60E, ARG64D, ARG64E, ARG74D, ARG74E, ARG79D, ARG79E, ASN279D, ASN279E, ASN337D, ASN337E, ASP303D, ASP303E, ASP61D, ASP61E, ASP67D, ASP67E, GLN109D, GLN109E, GLN278D, GLN278E, GLN280D, GLN280E, GLN70D, GLN70E, GLU117D, GLU117E, GLU275D, GLU275E, GLU369D, GLU66D, GLU66E, GLY104D, GLY104E, GLY112D, GLY112E, GLY113D, GLY113E, GLY63D, GLY63E, HIS271D, HIS271E, HIS309D, HIS309E, ILE270D, ILE270E, ILE277D, ILE277E, ILE295D, ILE295E, ILE65D, ILE65E, ILE98D, ILE98E, LEU107D, LEU107E, LEU110D, LEU110E, LEU111D, LEU111E, LEU304D, LEU304E, LEU307D, LEU307E, LEU3D, LEU3E, LEU95D, LEU95E, LYS101D, LYS101E, LYS114D, LYS114E, LYS99D, LYS99E, MET105D, MET105E, PHE338D, PRO106D, PRO106E, PRO336D, PRO336E, SER115D, SER115E, SER269D, SER269E, SER2E, SER306D, SER306E, THR296D, THR296E, THR333D, THR333E, THR68D, THR68E, TRP334D, TRP334E, TRP69D, TRP69E, TRP96D, TRP96E, TYR108D, TYR108E, TYR308D, TYR308E, TYR71D, VAL301D, VAL301E, VAL335D, VAL335E
• D-F: ALA223F, ALA224F, ALA229F, ALA244F, ARG116D, ARG118D, ARG146D, ARG201D, ARG217F, ARG225F, ARG251D, ARG251F, ARG254D, ARG311D, ARG396F, ASN191F, ASN246F, ASN279D, ASN337D, ASP206D, ASP207D, ASP283D, ASP332D, ASP399F, GLN247F, GLN278D, GLN280D, GLU117D, GLU187F, GLU222F, GLU231D, GLU245F, GLU248F, GLU255D, GLU255F, GLU398F, GLY156F, GLY205D, GLY227D, GLY227F, GLY339D, GLY400F, HIS192F, HIS209D, HIS216F, HIS234D, HIS256D, HIS256F, HIS309D, HIS364D, HIS404F, ILE221F, ILE253D, ILE253F, ILE277D, ILE282D, LEU190F, LEU208D, LEU218F, LEU226F, LEU235D, LEU250F, LEU252D, LEU252F, LEU261D, LEU276D, LEU304D, LEU307D, LEU397F, LEU402F, LYS114D, LYS188F, LYS195F, LYS228D, LYS228F, MET120D, PHE236D, PHE338D, PRO155F, PRO194F, PRO220F, PRO232D, PRO243F, PRO260D, PRO336D, SER115D, SER185F, SER249F, SER306D, THR186F, THR219F, THR257D, THR257F, THR258D, THR259D, THR333D, THR401F, TRP237D, TRP281D, TRP281F, TRP334D, TRP403F, TYR233D, TYR284D, TYR308D, VAL119D, VAL210D, VAL242F, VAL310D, VAL335D
• D-G: GLU255D, GLU255G
• E-F: ALA174E, ALA180E, ALA180F, ALA244E, ALA244F, ALA390E, ALA390F, ALA44E, ALA44F, ALA46E, ALA46F, ALA47E, ALA47F, ALA56E, ALA56F, ALA76E, ALA76F, ALA87E, ALA87F, ARG149E, ARG17E, ARG17F, ARG217E, ARG217F, ARG274E, ARG274F, ARG389E, ARG389F, ARG396E, ARG396F, ARG41E, ARG41F, ARG60E, ARG60F, ARG64E, ARG64F, ARG74E, ARG74F, ARG79E, ARG79F, ARG80E, ARG80F, ASN18E, ASN18F, ASN246E, ASN246F, ASN268E, ASN268F, ASN279E, ASN279F, ASN395E, ASN395F, ASN39E, ASN39F, ASP213E, ASP213F, ASP240E, ASP240F, ASP272E, ASP272F, ASP319E, ASP319F, ASP399E, ASP399F, ASP50E, ASP50F, ASP61E, ASP67E, ASP67F, CYS273E, CYS273F, GLN247E, GLN247F, GLN278E, GLN278F, GLN70E, GLN70F, GLU181E, GLU181F, GLU239E, GLU239F, GLU245E, GLU245F, GLU248E, GLU248F, GLU265E, GLU265F, GLU275E, GLU275F, GLU388E, GLU42E, GLU42F, GLU51E, GLU51F, GLU66E, GLU66F, GLY264E, GLY264F, GLY400E, GLY400F, GLY40E, GLY40F, GLY75E, GLY75F, GLY81E, GLY81F, HIS215E, HIS215F, HIS216E, HIS216F, HIS271E, HIS271F, HIS291E, HIS291F, HIS315E, HIS315F, HIS404E, HIS404F, HIS52E, HIS52F, ILE270E, ILE270F, ILE58E, ILE58F, ILE88E, ILE88F, LEU178E, LEU178F, LEU320E, LEU320F, LEU38E, LEU38F, LEU392E, LEU392F, LEU397E, LEU397F, LEU402E, LEU402F, LEU49E, LEU49F, LEU57E, LEU57F, LEU72E, LEU72F, MET287E, MET287F, MET43E, MET43F, MET85E, MET85F, PHE267E, PHE267F, PRO173E, PRO173F, PRO179E, PRO179F, PRO243E, PRO243F, PRO288E, PRO288F, PRO317E, PRO317F, PRO393E, PRO393F, PRO55E, PRO55F, PRO82E, PRO82F, SER177E, SER177F, SER249E, SER249F, SER269E, SER269F, SER391E, SER391F, THR37E, THR37F, THR401E, THR401F, THR68E, THR68F, THR84E, THR84F, THR86E, THR86F, TRP281E, TRP281F, TRP403E, TRP403F, TRP405E, TRP405F, TRP69E, TRP69F, TRP78E, TRP78F, TYR387E, TYR387F, TYR48E, TYR48F, TYR71E, TYR71F, TYR73E, TYR73F, TYR77E, TYR77F, VAL20E, VAL20F, VAL242E, VAL242F, VAL266E, VAL266F, VAL394E, VAL394F, VAL45E, VAL45F, VAL53E, VAL53F, VAL54E, VAL54F, VAL83E, VAL83F
• E-H: ALA223E, ALA224E, ALA229E, ALA244E, ARG116H, ARG118H, ARG146H, ARG201H, ARG217E, ARG225E, ARG251E, ARG251H, ARG254H, ARG311H, ARG396E, ASN191E, ASN246E, ASN279H, ASN337H, ASP206H, ASP207H, ASP283H, ASP332H, ASP399E, GLN247E, GLN278H, GLN280H, GLU117H, GLU187E, GLU222E, GLU231H, GLU245E, GLU248E, GLU255E, GLU255H, GLU398E, GLY156E, GLY205H, GLY227E, GLY227H, GLY339H, GLY400E, HIS192E, HIS209H, HIS216E, HIS234H, HIS256E, HIS256H, HIS309H, HIS364H, HIS404E, ILE221E, ILE253E, ILE253H, ILE277H, ILE282H, LEU190E, LEU208H, LEU218E, LEU226E, LEU235H, LEU250E, LEU252E, LEU252H, LEU261H, LEU276H, LEU304H, LEU307H, LEU397E, LEU402E, LYS114H, LYS188E, LYS195E, LYS228E, LYS228H, MET120H, PHE236H, PHE338H, PRO155E, PRO194E, PRO220E, PRO232H, PRO243E, PRO260H, PRO336H, SER115H, SER185E, SER249E, SER306H, THR186E, THR219E, THR257E, THR257H, THR258H, THR259H, THR333H, THR401E, TRP184E, TRP237H, TRP281E, TRP281H, TRP334H, TRP403E, TYR233H, TYR284H, TYR308H, VAL119H, VAL210H, VAL242E, VAL310H, VAL335H
• F-G: ALA223G, ALA224G, ALA229G, ALA244G, ARG116F, ARG118F, ARG146F, ARG201F, ARG217G, ARG225G, ARG251F, ARG251G, ARG254F, ARG311F, ARG396G, ASN191G, ASN246G, ASN279F, ASN337F, ASP206F, ASP207F, ASP283F, ASP332F, ASP399G, GLN247G, GLN278F, GLN280F, GLU117F, GLU187G, GLU222G, GLU231F, GLU245G, GLU248G, GLU255F, GLU255G, GLU398G, GLY156G, GLY205F, GLY227F, GLY227G, GLY339F, GLY400G, HIS192G, HIS209F, HIS216G, HIS234F, HIS256F, HIS256G, HIS309F, HIS364F, HIS404G, ILE221G, ILE253F, ILE253G, ILE277F, ILE282F, LEU190G, LEU208F, LEU218G, LEU226G, LEU235F, LEU250G, LEU252F, LEU252G, LEU261F, LEU304F, LEU307F, LEU397G, LEU402G, LYS114F, LYS188G, LYS195G, LYS228F, LYS228G, MET120F, PHE236F, PHE338F, PRO155G, PRO194G, PRO220G, PRO232F, PRO243G, PRO260F, PRO336F, SER115F, SER185G, SER249G, SER306F, THR186G, THR219G, THR257F, THR257G, THR258F, THR259F, THR333F, THR401G, TRP184G, TRP237F, TRP281F, TRP281G, TRP334F, TRP403G, TYR233F, TYR284F, TYR308F, VAL119F, VAL183G, VAL210F, VAL242G, VAL310F, VAL335F
• F-H: ALA100F, ALA100H, ALA102F, ALA102H, ALA103F, ALA103H, ALA302F, ALA302H, ALA62F, ALA62H, ARG116F, ARG116H, ARG118F, ARG118H, ARG274F, ARG274H, ARG299F, ARG299H, ARG300F, ARG300H, ARG60F, ARG60H, ARG64F, ARG64H, ARG74F, ARG74H, ARG79F, ARG79H, ASN279F, ASN279H, ASN337F, ASN337H, ASP303F, ASP303H, ASP61F, ASP61H, ASP67F, ASP67H, GLN109F, GLN109H, GLN278F, GLN278H, GLN280F, GLN280H, GLN70F, GLN70H, GLU117F, GLU117H, GLU275F, GLU275H, GLU66F, GLU66H, GLY104F, GLY104H, GLY112F, GLY112H, GLY113F, GLY113H, GLY63F, GLY63H, HIS271F, HIS271H, HIS309F, HIS309H, ILE270F, ILE270H, ILE277F, ILE277H, ILE295F, ILE295H, ILE65F, ILE65H, ILE98F, ILE98H, LEU107F, LEU107H, LEU110F, LEU110H, LEU111F, LEU111H, LEU304F, LEU304H, LEU307F, LEU307H, LEU3F, LEU3H, LEU95F, LEU95H, LYS101F, LYS101H, LYS114F, LYS114H, LYS99F, LYS99H, MET105F, MET105H, PHE338F, PRO106F, PRO106H, PRO336F, PRO336H, SER115F, SER115H, SER269F, SER306F, SER306H, THR296F, THR296H, THR333F, THR333H, THR68F, THR68H, TRP334F, TRP334H, TRP69F, TRP69H, TRP96F, TRP96H, TYR108F, TYR108H, TYR308F, TYR308H, VAL301F, VAL301H, VAL335F, VAL335H
• G-H: ALA180G, ALA180H, ALA244G, ALA244H, ALA390G, ALA390H, ALA44G, ALA44H, ALA46G, ALA46H, ALA47G, ALA47H, ALA56G, ALA56H, ALA76G, ALA76H, ALA87G, ALA87H, ARG17G, ARG17H, ARG217G, ARG217H, ARG274G, ARG274H, ARG286G, ARG286H, ARG389G, ARG389H, ARG396G, ARG396H, ARG41G, ARG41H, ARG60G, ARG60H, ARG64G, ARG64H, ARG74G, ARG74H, ARG79G, ARG79H, ARG80G, ARG80H, ASN18G, ASN18H, ASN246G, ASN246H, ASN268G, ASN268H, ASN279G, ASN279H, ASN395G, ASN395H, ASN39G, ASN39H, ASP213G, ASP213H, ASP240G, ASP240H, ASP272G, ASP272H, ASP319G, ASP319H, ASP399G, ASP399H, ASP50G, ASP50H, ASP61G, ASP67G, ASP67H, CYS273G, CYS273H, GLN247G, GLN247H, GLN278G, GLN278H, GLN70G, GLN70H, GLU181G, GLU181H, GLU239G, GLU239H, GLU245G, GLU245H, GLU248G, GLU248H, GLU265G, GLU265H, GLU275G, GLU275H, GLU388G, GLU388H, GLU42G, GLU42H, GLU51G, GLU51H, GLU66G, GLU66H, GLY264G, GLY264H, GLY400G, GLY400H, GLY40G, GLY40H, GLY75G, GLY75H, GLY81G, GLY81H, HIS215G, HIS215H, HIS216G, HIS216H, HIS271G, HIS271H, HIS291G, HIS291H, HIS315G, HIS315H, HIS404G, HIS404H, HIS52G, HIS52H, ILE270G, ILE270H, ILE58G, ILE58H, ILE88G, ILE88H, LEU178G, LEU178H, LEU320G, LEU320H, LEU38G, LEU38H, LEU392G, LEU392H, LEU397G, LEU397H, LEU402G, LEU402H, LEU49G, LEU49H, LEU57G, LEU57H, LEU72G, LEU72H, MET287G, MET287H, MET43G, MET43H, MET85G, MET85H, PHE267G, PHE267H, PRO179G, PRO179H, PRO243G, PRO243H, PRO288G, PRO288H, PRO317G, PRO317H, PRO393G, PRO393H, PRO55G, PRO55H, PRO82G, PRO82H, SER177G, SER177H, SER249G, SER249H, SER269G, SER269H, SER391G, SER391H, THR37G, THR37H, THR401G, THR401H, THR68G, THR68H, THR84G, THR84H, THR86G, THR86H, TRP281G, TRP281H, TRP403G, TRP403H, TRP405G, TRP405H, TRP69G, TRP69H, TRP78G, TRP78H, TYR387G, TYR387H, TYR48G, TYR48H, TYR71G, TYR71H, TYR73G, TYR73H, TYR77G, TYR77H, VAL20G, VAL20H, VAL242G, VAL242H, VAL266G, VAL266H, VAL394G, VAL394H, VAL45G, VAL45H, VAL53G, VAL53H, VAL54G, VAL54H, VAL83G, VAL83H