3OPY

crystal structure of pichia pastoris phosphofructokinase in the t- state

• Total interactions analyzed: 66
• Total true interactions: 30
• Strongest Interaction:
  • Chains: C-H
  • Int. Res.: 2
  • Norm. En. per Res.: -8.9206
• Hub Node: A(7)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-101.5257	13.4942	-897.23	-985.2615	383	43	16	35418	7	125	148
A-C	0.0	0.0	-0.1739	-0.1739	18	0	0	89	0	12	12
A-D	-164.0828	-12.4606	-610.501	-787.0444	237	37	26	25028	1	28	25
A-E	-33.5138	-27.8091	-274.461	-335.7838	89	11	4	9630	2	32	15
A-F	0.0	-15.9571	-16.8	-32.757	12	2	0	418	1	3	3
A-J	-21.0878	16.4816			14
A-K	-23.838	-23.8879			10
B-C	-161.3826	-11.856	-622.433	-795.6716	242	26	28	25034	1	27	25
B-D	0.0	0.0	-40.5316	-40.5316	50	9	3	3074	0	4	4
B-E	0.0	-17.5426	-17.6952	-35.2378	12	1	0	433	1	3	4
B-I	-25.5034	-60.0892			16
C-D	-90.8062	13.9636	-876.2	-953.0426	373	42	17	35026	8	125	147
C-G	-22.2248	-27.1779	-274.724	-324.1266	88	12	4	9635	2	32	16
C-H	0.0	-17.8412	0.0	-17.8412	2	0	0	0	0	0	0
C-I	-18.633	2.4841			16
C-L	-24.5828	-4.9745			12
D-G	0.0	-15.4072	-17.8054	-33.2126	12	1	0	429	1	3	4
D-J	-24.9894	-62.2659			16
E-F	-93.1035	10.9166	-887.511	-969.6979	381	44	16	35287	7	122	148
E-G	0.0	0.0	-0.1366	-0.1366	18	0	0	72	0	12	11
E-H	-139.9978	-13.8286	-484.456	-638.2824	187	23	19	19229	0	16	18
E-I	-16.5815	-6.2853			11
E-L	-13.7622	13.2964			16
F-G	-157.3904	-10.7844	-630.376	-798.5509	239	30	28	25366	1	28	25
F-H	0.0	0.0	-15.9639	-15.9639	25	4	1	1508	0	2	2
F-K	-27.5919	-68.6711			16
G-H	-101.0203	10.8297	-180.791	-270.9815	142	10	3	6989	2	41	47
G-J	-26.8833	-9.0619			14
G-K	-15.2808	18.8444			16
H-L	-40.5362	-61.5162			20

Interface residues

• A-B: ALA222A, ALA254B, ALA282A, ALA355B, ALA361B, ALA363B, ALA369B, ALA36A, ALA389A, ALA391A, ALA392A, ALA397A, ALA473B, ALA499A, ALA581B, ALA583B, ALA606B, ALA608A, ALA615B, ALA655B, ALA684B, ALA733B, ALA734B, ALA735B, ALA74A, ALA754A, ALA759A, ALA834B, ALA860A, ALA94A, ARG255B, ARG283A, ARG351B, ARG354B, ARG368B, ARG377B, ARG379A, ARG38A, ARG396A, ARG405A, ARG421B, ARG424B, ARG45A, ARG460B, ARG469B, ARG478B, ARG487A, ARG490A, ARG496A, ARG571B, ARG616B, ARG621B, ARG635A, ARG643A, ARG643B, ARG670A, ARG683B, ARG685B, ARG692B, ARG739B, ARG763A, ARG764A, ARG78A, ARG81A, ARG823A, ARG828B, ARG858A, ARG881B, ASN197B, ASN226A, ASN250B, ASN27A, ASN44A, ASN578B, ASN587B, ASN614A, ASN624B, ASN636A, ASN642B, ASN647B, ASN660A, ASN669A, ASN687B, ASN738B, ASN876B, ASP192B, ASP221A, ASP350B, ASP357B, ASP360B, ASP385A, ASP388A, ASP445B, ASP47A, ASP485A, ASP650B, ASP727B, ASP753A, ASP792B, ASP841A, CYS444B, CYS726B, CYS752A, GLN102A, GLN468B, GLN495A, GLN731B, GLN746B, GLN757A, GLN772A, GLN793B, GLN840B, GLN841B, GLN85A, GLN866A, GLN867A, GLN882B, GLU219B, GLU222B, GLU23A, GLU246B, GLU248A, GLU373B, GLU378A, GLU382A, GLU401A, GLU432B, GLU460A, GLU473A, GLU49A, GLU60A, GLU618B, GLU638B, GLU64A, GLU659B, GLU665A, GLU673B, GLU724B, GLU770A, GLU79A, GLU806B, GLU815B, GLU856A, GLU86A, GLU93A, GLY104A, GLY105A, GLY191B, GLY195B, GLY219A, GLY220A, GLY247B, GLY248B, GLY252B, GLY275A, GLY276A, GLY280A, GLY376B, GLY404A, GLY465B, GLY470B, GLY471B, GLY492A, GLY497A, GLY498A, GLY580B, GLY584B, GLY601B, GLY607A, GLY613B, GLY635B, GLY636B, GLY640B, GLY652B, GLY662A, GLY662B, GLY663A, GLY667A, GLY750A, GLY77A, GLY794B, GLY827B, GLY837B, GLY842B, GLY843B, GLY863A, GLY868A, GLY97A, HIS35A, HIS366B, HIS394A, HIS466B, HIS493A, HIS605A, HIS608B, HIS617B, HIS644A, HIS838B, HIS864A, ILE251B, ILE274A, ILE278A, ILE279A, ILE332B, ILE352B, ILE356B, ILE359B, ILE360A, ILE371B, ILE380A, ILE387A, ILE427B, ILE488A, ILE607B, ILE61A, ILE623B, ILE651B, ILE666A, ILE686B, ILE702B, ILE729B, ILE827A, ILE835B, ILE844B, ILE878B, LEU244B, LEU383A, LEU464B, LEU491A, LEU50A, LEU566B, LEU568B, LEU613A, LEU614B, LEU634B, LEU63A, LEU68A, LEU691B, LEU80A, LEU84A, LEU95A, LEU96A, LYS425B, LYS453A, LYS573B, LYS59A, LYS660B, LYS730B, LYS756A, LYS795B, LYS797B, LYS82A, LYS832B, LYS869A, LYS875B, MET196B, MET225A, MET375B, MET403A, MET586B, MET653B, MET723B, PHE22A, PHE26A, PHE34A, PHE370B, PHE398A, PHE48A, PHE657B, PHE658B, PHE663B, PHE66A, PHE741B, PHE767A, PHE880B, PRO100A, PRO194B, PRO223A, PRO563B, PRO564B, PRO567B, PRO582B, PRO604B, PRO609A, PRO67A, PRO689B, PRO836B, PRO83A, PRO845B, PRO862A, PRO871A, SER193B, SER273A, SER347B, SER365B, SER367B, SER375A, SER393A, SER39A, SER46A, SER565B, SER611A, SER612B, SER619B, SER622B, SER637B, SER65A, SER664A, SER671A, SER690B, SER69A, SER721B, SER732B, SER758A, SER760A, SER762A, SER870A, SER877B, SER879B, SER87A, SER92A, THR217A, THR249B, THR253B, THR277A, THR281A, THR30A, THR362B, THR37A, THR390A, THR459B, THR462B, THR463B, THR472B, THR486A, THR489A, THR610A, THR641B, THR644B, THR661A, THR668A, THR717B, THR736B, THR743A, THR747A, THR796B, THR833B, THR859A, TRP62A, TYR358B, TYR386A, TYR40A, TYR605B, TYR656B, TYR661B, TYR688B, TYR725B, TYR751A, TYR90A, VAL245B, VAL372B, VAL384A, VAL399A, VAL400A, VAL402A, VAL41A, VAL461B, VAL467B, VAL474B, VAL494A, VAL562B, VAL579B, VAL603B, VAL620B, VAL71A, VAL728B, VAL72A, VAL743B, VAL755A, VAL769A, VAL839B, VAL861A, VAL865A
• A-C: ARG45A, ARG45C, ASN44A, ASN44C, ASP56A, ASP56C, GLU49A, GLU49C, ILE53A, ILE53C, ILE58A, ILE58C, LEU112A, LEU112C, LYS42A, LYS42C, SER113A, SER113C
• A-D: ALA132A, ALA139A, ALA151D, ALA17D, ALA69D, ALA776D, ALA808D, ALA844A, ALA845A, ALA850A, ALA94A, ALA99D, ARG111A, ARG38A, ARG80D, ASN114A, ASN120A, ASN121A, ASN148D, ASN153D, ASN17A, ASN56D, ASN57D, ASN783D, ASN78D, ASN800A, ASN81D, ASN8D, ASN97D, ASP122A, ASP135A, ASP135D, ASP166A, ASP56A, ASP76D, ASP781D, ASP822D, ASP823D, ASP841A, ASP8A, GLN102A, GLN120D, GLN55D, GLN61D, GLN74D, GLN777D, GLN77D, GLN802A, GLN805A, GLN95D, GLU118A, GLU126A, GLU130D, GLU154D, GLU157A, GLU49A, GLU52D, GLU53D, GLU64A, GLU67D, GLU779D, GLU806A, GLU815D, GLU824D, GLU849A, GLY104A, GLY105A, GLY125A, GLY142D, GLY145D, GLY165A, GLY33A, GLY35D, GLY52A, GLY848A, GLY853A, GLY9D, HIS35A, HIS68D, ILE134A, ILE13D, ILE141D, ILE168A, ILE53A, ILE60D, ILE63D, ILE6A, ILE75D, ILE773D, ILE782D, ILE799A, ILE79D, ILE808A, ILE817D, ILE820D, ILE821D, ILE843A, ILE846A, ILE847A, ILE94D, ILE98D, LEU108D, LEU110A, LEU112A, LEU123A, LEU137A, LEU137D, LEU140D, LEU141A, LEU155A, LEU15D, LEU176A, LEU32A, LEU34D, LEU49D, LEU50A, LEU51D, LEU68A, LEU6D, LEU775D, LEU778D, LEU801A, LEU812D, LEU82D, LEU842A, LEU941D, LEU95A, LEU96A, LEU9A, LYS101D, LYS107D, LYS109A, LYS119A, LYS136A, LYS138A, LYS140A, LYS147D, LYS152A, LYS180A, LYS31A, LYS786D, LYS810D, LYS836A, MET164A, MET780D, PHE100D, PHE11A, PHE129A, PHE12D, PHE130A, PHE143D, PHE146D, PHE14A, PHE150D, PHE158A, PHE16D, PHE170A, PHE28A, PHE33D, PHE34A, PHE36D, PHE48A, PHE66A, PHE7D, PRO100A, PRO124A, PRO128D, PRO136D, PRO149D, PRO67A, PRO798A, SER102D, SER103D, SER104D, SER10A, SER11D, SER122D, SER127D, SER133A, SER139D, SER13A, SER151A, SER169A, SER171A, SER172A, SER178A, SER54A, SER57A, SER59D, SER5A, SER5D, SER65A, SER69A, SER73D, SER774D, SER7A, SER809D, SER818D, SER835A, SER857A, SER96D, THR10D, THR128A, THR12A, THR131A, THR133D, THR14D, THR160A, THR16A, THR37A, THR51A, THR803A, THR813D, THR819D, THR839A, THR83D, TRP62A, TYR101A, TYR173A, TYR29A, TYR767D, TYR838A, TYR98A, VAL106A, VAL107A, VAL127A, VAL134D, VAL152D, VAL156A, VAL15A, VAL167A, VAL58D, VAL72D, VAL804A, VAL811D, VAL816D, VAL837A
• A-E: ALA639A, ALA639E, ALA681A, ALA681E, ALA710A, ALA710E, ALA712A, ALA712E, ALA905A, ALA905E, ARG643A, ARG643E, ARG711A, ARG711E, ARG908A, ARG908E, ARG911A, ARG911E, ASP675A, ASP675E, ASP676A, ASP676E, ASP906A, ASP906E, ASP915A, ASP915E, ASP916A, ASP916E, GLN685A, GLN685E, GLN686A, GLN686E, GLN713A, GLN713E, GLU907A, GLU907E, GLY645A, GLY645E, GLY678A, GLY678E, GLY917A, GLY917E, HIS644A, HIS644E, HIS909A, HIS909E, ILE642A, ILE642E, ILE716A, ILE716E, LEU641A, LEU641E, LEU910A, LEU910E, LYS688A, LYS688E, LYS919A, LYS919E, MET677A, MET677E, PHE684A, PHE684E, PHE912A, PHE912E, PHE913A, PHE913E, PRO715A, PRO715E, SER904A, SER904E, THR679A, THR679E, TYR682A, TYR682E, TYR683A, TYR683E, TYR687A, TYR687E, TYR714A, TYR714E, TYR914A, TYR914E, VAL647A, VAL680A, VAL680E, VAL918A, VAL918E, VAL929A, VAL929E
• A-F: ALA790F, ARG828F, ASN902A, ASP915A, ASP916A, GLN793F, GLY827F, GLY917A, LYS786F, SER826F, TYR914A, VAL918A
• A-J: ARG212J, ARG517A, ARG813A, ARG987A, ASP211J, ASP229J, ASP318J, ASP514A, GLU213J, GLU521A, GLU806A, GLU809A, SER219J, THR988A
• A-K: ASN900A, ASP117K, ASP915A, ASP916A, GLN116K, HIS899A, LYS238K, LYS239K, LYS270K, LYS898A
• B-C: ALA132C, ALA139C, ALA151B, ALA17B, ALA69B, ALA776B, ALA808B, ALA844C, ALA845C, ALA850C, ALA94C, ALA99B, ARG111C, ARG155B, ARG38C, ARG80B, ASN120C, ASN121C, ASN148B, ASN153B, ASN17C, ASN56B, ASN57B, ASN783B, ASN78B, ASN800C, ASN807B, ASN81B, ASN8B, ASN97B, ASP122C, ASP135B, ASP135C, ASP166C, ASP56C, ASP76B, ASP781B, ASP822B, ASP823B, ASP841C, ASP8C, GLN102C, GLN120B, GLN55B, GLN61B, GLN74B, GLN777B, GLN77B, GLN802C, GLN805C, GLN95B, GLU118C, GLU126C, GLU130B, GLU154B, GLU157C, GLU49C, GLU52B, GLU53B, GLU64C, GLU67B, GLU779B, GLU806C, GLU815B, GLU824B, GLU849C, GLY104C, GLY105C, GLY125C, GLY142B, GLY145B, GLY165C, GLY33C, GLY35B, GLY52C, GLY772B, GLY848C, GLY853C, GLY9B, HIS35C, HIS68B, ILE108C, ILE134C, ILE13B, ILE141B, ILE168C, ILE53C, ILE60B, ILE63B, ILE6C, ILE75B, ILE773B, ILE782B, ILE799C, ILE79B, ILE808C, ILE817B, ILE820B, ILE821B, ILE843C, ILE846C, ILE847C, ILE94B, ILE98B, LEU105B, LEU108B, LEU110C, LEU112C, LEU123C, LEU137B, LEU137C, LEU140B, LEU141C, LEU155C, LEU15B, LEU176C, LEU32C, LEU34B, LEU49B, LEU50C, LEU51B, LEU68C, LEU6B, LEU775B, LEU778B, LEU801C, LEU812B, LEU82B, LEU842C, LEU941B, LEU95C, LEU96C, LEU9C, LYS101B, LYS107B, LYS109C, LYS119C, LYS136C, LYS138C, LYS140C, LYS147B, LYS152C, LYS180C, LYS31C, LYS786B, LYS810B, LYS836C, LYS852C, MET164C, MET780B, PHE100B, PHE11C, PHE129C, PHE12B, PHE130C, PHE143B, PHE146B, PHE14C, PHE150B, PHE158C, PHE16B, PHE170C, PHE28C, PHE33B, PHE34C, PHE36B, PHE48C, PHE66C, PHE7B, PRO100C, PRO124C, PRO128B, PRO136B, PRO149B, PRO67C, PRO798C, SER102B, SER103B, SER104B, SER10C, SER11B, SER122B, SER127B, SER133C, SER139B, SER13C, SER151C, SER169C, SER171C, SER172C, SER178C, SER54C, SER57C, SER59B, SER5B, SER5C, SER65C, SER69C, SER73B, SER774B, SER7C, SER809B, SER818B, SER835C, SER857C, SER96B, THR10B, THR128C, THR12C, THR131C, THR133B, THR14B, THR160C, THR16C, THR37C, THR51C, THR803C, THR813B, THR819B, THR839C, THR83B, TRP62C, TYR101C, TYR173C, TYR29C, TYR767B, TYR838C, TYR98C, VAL106C, VAL107C, VAL127C, VAL134B, VAL152B, VAL156C, VAL15C, VAL167C, VAL58B, VAL72B, VAL804C, VAL811B, VAL816B, VAL837C
• B-D: ALA615B, ALA615D, ALA649B, ALA649D, ALA655B, ALA655D, ARG616B, ARG616D, ASN148B, ASN148D, ASN647B, ASN647D, ASP648B, ASP648D, ASP650B, ASP650D, GLY145B, GLY145D, GLY652B, GLY652D, HIS617B, HIS617D, ILE651B, ILE651D, ILE654B, ILE654D, LEU614B, LEU614D, LYS147B, LYS147D, MET653B, MET653D, PHE143B, PHE143D, PHE146B, PHE146D, PHE150B, PHE150D, PHE611B, PHE611D, PHE657B, PHE657D, PRO149B, PRO149D, SER612B, SER612D, TYR656B, TYR656D, TYR688B, TYR688D
• B-E: ALA790B, ARG828B, ASN902E, ASP915E, ASP916E, GLN793B, GLY827B, GLY917E, LYS786B, SER826B, TYR914E, VAL918E
• B-I: ALA298I, ARG241B, ARG301I, ARG327I, ARG800B, ARG938B, ASP351I, ASP792B, ASP933B, GLU264I, GLU787B, GLU930B, HIS238B, LYS795B, MET780B, TYR209B
• C-D: ALA222C, ALA254D, ALA282C, ALA355D, ALA361D, ALA363D, ALA369D, ALA36C, ALA389C, ALA391C, ALA392C, ALA397C, ALA499C, ALA581D, ALA583D, ALA606D, ALA608C, ALA615D, ALA655D, ALA684D, ALA733D, ALA734D, ALA735D, ALA74C, ALA754C, ALA759C, ALA834D, ALA860C, ALA94C, ARG255D, ARG283C, ARG351D, ARG354D, ARG368D, ARG377D, ARG379C, ARG38C, ARG396C, ARG405C, ARG421D, ARG424D, ARG45C, ARG460D, ARG469D, ARG478D, ARG487C, ARG490C, ARG496C, ARG571D, ARG616D, ARG621D, ARG635C, ARG643C, ARG643D, ARG670C, ARG683D, ARG685D, ARG692D, ARG739D, ARG763C, ARG764C, ARG78C, ARG81C, ARG823C, ARG828D, ARG858C, ARG881D, ASN197D, ASN226C, ASN250D, ASN27C, ASN44C, ASN587D, ASN614C, ASN624D, ASN636C, ASN642D, ASN647D, ASN660C, ASN669C, ASN687D, ASN738D, ASN876D, ASP192D, ASP221C, ASP350D, ASP357D, ASP360D, ASP385C, ASP388C, ASP445D, ASP47C, ASP485C, ASP650D, ASP727D, ASP753C, ASP792D, ASP841C, CYS444D, CYS726D, CYS752C, GLN102C, GLN468D, GLN495C, GLN731D, GLN746D, GLN757C, GLN772C, GLN793D, GLN840D, GLN841D, GLN85C, GLN866C, GLN867C, GLN882D, GLU219D, GLU222D, GLU23C, GLU246D, GLU248C, GLU373D, GLU378C, GLU382C, GLU401C, GLU432D, GLU460C, GLU49C, GLU60C, GLU618D, GLU638D, GLU64C, GLU659D, GLU665C, GLU673D, GLU724D, GLU79C, GLU806D, GLU815D, GLU856C, GLU86C, GLU93C, GLY104C, GLY105C, GLY191D, GLY219C, GLY220C, GLY247D, GLY248D, GLY252D, GLY275C, GLY276C, GLY280C, GLY376D, GLY404C, GLY465D, GLY470D, GLY471D, GLY492C, GLY497C, GLY498C, GLY580D, GLY584D, GLY601D, GLY607C, GLY613D, GLY635D, GLY636D, GLY640D, GLY652D, GLY662C, GLY662D, GLY663C, GLY667C, GLY750C, GLY77C, GLY794D, GLY827D, GLY837D, GLY842D, GLY843D, GLY863C, GLY868C, GLY97C, HIS35C, HIS366D, HIS394C, HIS466D, HIS493C, HIS605C, HIS608D, HIS617D, HIS644C, HIS838D, HIS864C, ILE251D, ILE274C, ILE278C, ILE279C, ILE332D, ILE352D, ILE356D, ILE359D, ILE360C, ILE371D, ILE380C, ILE381C, ILE387C, ILE427D, ILE488C, ILE607D, ILE61C, ILE623D, ILE651D, ILE666C, ILE686D, ILE702D, ILE729D, ILE835D, ILE844D, ILE878D, LEU244D, LEU383C, LEU464D, LEU491C, LEU50C, LEU566D, LEU568D, LEU613C, LEU614D, LEU634D, LEU63C, LEU68C, LEU691D, LEU80C, LEU84C, LEU95C, LEU96C, LYS425D, LYS453C, LYS573D, LYS59C, LYS660D, LYS730D, LYS756C, LYS795D, LYS797D, LYS82C, LYS832D, LYS869C, LYS875D, MET196D, MET375D, MET403C, MET586D, MET653D, MET723D, PHE22C, PHE26C, PHE34C, PHE370D, PHE398C, PHE48C, PHE657D, PHE658D, PHE663D, PHE66C, PHE741D, PHE767C, PHE880D, PRO100C, PRO194D, PRO223C, PRO563D, PRO564D, PRO567D, PRO582D, PRO604D, PRO609C, PRO67C, PRO689D, PRO836D, PRO83C, PRO845D, PRO862C, PRO871C, SER193D, SER347D, SER365D, SER393C, SER39C, SER46C, SER565D, SER611C, SER612D, SER619D, SER622D, SER637D, SER65C, SER664C, SER671C, SER690D, SER69C, SER721D, SER732D, SER758C, SER760C, SER762C, SER870C, SER877D, SER879D, SER87C, SER92C, THR217C, THR249D, THR253D, THR277C, THR281C, THR30C, THR362D, THR37C, THR390C, THR459D, THR462D, THR463D, THR472D, THR486C, THR489C, THR610C, THR641D, THR644D, THR661C, THR668C, THR717D, THR736D, THR747C, THR796D, THR833D, THR859C, TRP62C, TYR358D, TYR386C, TYR40C, TYR605D, TYR656D, TYR661D, TYR688D, TYR725D, TYR751C, TYR90C, VAL245D, VAL372D, VAL384C, VAL399C, VAL400C, VAL402C, VAL41C, VAL461D, VAL467D, VAL474D, VAL494C, VAL562D, VAL579D, VAL603D, VAL620D, VAL71C, VAL728D, VAL72C, VAL743D, VAL755C, VAL769C, VAL839D, VAL861C, VAL865C
• C-G: ALA639C, ALA639G, ALA681C, ALA681G, ALA710C, ALA710G, ALA712C, ALA712G, ALA905C, ALA905G, ARG643C, ARG643G, ARG711C, ARG711G, ARG908C, ARG908G, ARG911C, ARG911G, ASP675C, ASP675G, ASP676C, ASP676G, ASP906C, ASP906G, ASP915C, ASP915G, ASP916C, ASP916G, GLN685C, GLN685G, GLN686C, GLN686G, GLN713C, GLN713G, GLU907C, GLU907G, GLY645C, GLY645G, GLY678C, GLY678G, GLY917C, GLY917G, HIS644C, HIS644G, HIS909C, HIS909G, ILE642C, ILE642G, ILE716C, ILE716G, LEU641C, LEU641G, LEU910C, LEU910G, LYS688C, LYS688G, LYS919C, LYS919G, MET677C, MET677G, PHE684C, PHE684G, PHE912C, PHE912G, PHE913C, PHE913G, PRO715C, PRO715G, SER904C, SER904G, THR679C, THR679G, TYR682C, TYR682G, TYR683C, TYR683G, TYR687C, TYR687G, TYR714C, TYR714G, TYR914C, TYR914G, VAL680C, VAL680G, VAL918C, VAL918G, VAL929C, VAL929G
• C-H: ARG828H, ASP916C
• C-I: ARG212I, ARG517C, ARG813C, ARG987C, ASP211I, ASP229I, ASP318I, ASP514C, GLN802C, GLU213I, GLU521C, GLU806C, GLU809C, SER219I, THR988C, TYR324I
• C-L: ASN900C, ASP117L, ASP915C, ASP916C, GLN116L, GLU84L, HIS899C, LYS238L, LYS239L, LYS270L, LYS898C, SER114L
• D-G: ALA790D, ARG828D, ASN902G, ASP915G, ASP916G, GLN793D, GLY827D, GLY917G, LYS786D, SER826D, TYR914G, VAL918G
• D-J: ALA298J, ARG241D, ARG301J, ARG327J, ARG800D, ARG938D, ASP351J, ASP792D, ASP933D, GLU264J, GLU787D, GLU930D, HIS238D, LYS795D, MET780D, TYR209D
• E-F: ALA222E, ALA254F, ALA282E, ALA355F, ALA361F, ALA363F, ALA369F, ALA36E, ALA389E, ALA391E, ALA392E, ALA397E, ALA499E, ALA581F, ALA583F, ALA606F, ALA608E, ALA615F, ALA655F, ALA684F, ALA733F, ALA734F, ALA735F, ALA74E, ALA754E, ALA759E, ALA834F, ALA860E, ALA94E, ARG255F, ARG283E, ARG351F, ARG354F, ARG368F, ARG377F, ARG379E, ARG38E, ARG396E, ARG405E, ARG421F, ARG424F, ARG45E, ARG460F, ARG469F, ARG478F, ARG487E, ARG490E, ARG496E, ARG571F, ARG616F, ARG621F, ARG635E, ARG643E, ARG643F, ARG670E, ARG683F, ARG685F, ARG692F, ARG739F, ARG763E, ARG764E, ARG78E, ARG81E, ARG823E, ARG828F, ARG858E, ARG881F, ASN197F, ASN226E, ASN250F, ASN27E, ASN44E, ASN587F, ASN614E, ASN624F, ASN636E, ASN642F, ASN647F, ASN660E, ASN669E, ASN687F, ASN738F, ASN876F, ASP192F, ASP221E, ASP350F, ASP357F, ASP360F, ASP385E, ASP388E, ASP445F, ASP47E, ASP485E, ASP560F, ASP650F, ASP727F, ASP753E, ASP792F, ASP841E, CYS444F, CYS726F, CYS752E, GLN102E, GLN468F, GLN495E, GLN731F, GLN746F, GLN757E, GLN772E, GLN793F, GLN840F, GLN841F, GLN85E, GLN866E, GLN867E, GLN882F, GLU219F, GLU222F, GLU23E, GLU246F, GLU248E, GLU373F, GLU378E, GLU382E, GLU401E, GLU432F, GLU460E, GLU49E, GLU60E, GLU618F, GLU638F, GLU64E, GLU659F, GLU665E, GLU673F, GLU724F, GLU770E, GLU79E, GLU806F, GLU815F, GLU856E, GLU86E, GLU93E, GLY104E, GLY105E, GLY191F, GLY219E, GLY220E, GLY247F, GLY248F, GLY252F, GLY275E, GLY276E, GLY280E, GLY376F, GLY404E, GLY465F, GLY470F, GLY471F, GLY492E, GLY497E, GLY498E, GLY580F, GLY584F, GLY601F, GLY607E, GLY613F, GLY635F, GLY636F, GLY640F, GLY652F, GLY662E, GLY662F, GLY663E, GLY667E, GLY747F, GLY750E, GLY77E, GLY794F, GLY827F, GLY837F, GLY842F, GLY843F, GLY863E, GLY868E, GLY97E, HIS35E, HIS366F, HIS394E, HIS466F, HIS493E, HIS605E, HIS608F, HIS617F, HIS644E, HIS838F, HIS864E, ILE251F, ILE274E, ILE278E, ILE279E, ILE332F, ILE352F, ILE356F, ILE359F, ILE360E, ILE371F, ILE380E, ILE381E, ILE387E, ILE427F, ILE488E, ILE607F, ILE61E, ILE623F, ILE651F, ILE666E, ILE686F, ILE702F, ILE729F, ILE827E, ILE835F, ILE844F, ILE878F, LEU244F, LEU383E, LEU464F, LEU491E, LEU50E, LEU566F, LEU568F, LEU613E, LEU614F, LEU634F, LEU63E, LEU68E, LEU691F, LEU80E, LEU84E, LEU95E, LEU96E, LYS425F, LYS453E, LYS573F, LYS59E, LYS660F, LYS730F, LYS756E, LYS795F, LYS797F, LYS82E, LYS832F, LYS869E, LYS875F, MET196F, MET375F, MET403E, MET586F, MET653F, MET723F, PHE22E, PHE26E, PHE34E, PHE370F, PHE398E, PHE48E, PHE657F, PHE658F, PHE663F, PHE66E, PHE741F, PHE767E, PHE880F, PRO100E, PRO194F, PRO223E, PRO563F, PRO564F, PRO567F, PRO582F, PRO604F, PRO609E, PRO67E, PRO689F, PRO836F, PRO83E, PRO845F, PRO862E, PRO871E, SER193F, SER273E, SER347F, SER365F, SER367F, SER393E, SER39E, SER46E, SER472E, SER565F, SER611E, SER612F, SER619F, SER622F, SER637F, SER65E, SER664E, SER671E, SER690F, SER69E, SER721F, SER732F, SER758E, SER760E, SER762E, SER870E, SER877F, SER879F, SER87E, SER92E, THR217E, THR249F, THR253F, THR277E, THR281E, THR30E, THR362F, THR37E, THR390E, THR459F, THR462F, THR463F, THR472F, THR486E, THR489E, THR610E, THR641F, THR644F, THR661E, THR668E, THR717F, THR736F, THR743E, THR747E, THR796F, THR833F, THR859E, TRP62E, TYR358F, TYR386E, TYR40E, TYR605F, TYR656F, TYR661F, TYR688F, TYR725F, TYR751E, TYR90E, VAL245F, VAL372F, VAL384E, VAL399E, VAL400E, VAL402E, VAL41E, VAL461F, VAL467F, VAL474F, VAL494E, VAL562F, VAL579F, VAL603F, VAL620F, VAL71E, VAL728F, VAL72E, VAL743F, VAL755E, VAL769E, VAL839F, VAL861E, VAL865E
• E-G: ARG45E, ARG45G, ASN44E, ASN44G, ASP56E, ASP56G, GLU49E, GLU49G, ILE53E, ILE53G, ILE58E, ILE58G, LEU112E, LEU112G, LYS42E, LYS42G, SER113E, SER113G
• E-H: ALA132E, ALA139E, ALA151H, ALA17H, ALA69H, ALA94E, ALA99H, ARG111E, ARG155H, ARG38E, ARG80H, ASN114E, ASN120E, ASN121E, ASN148H, ASN153H, ASN17E, ASN56H, ASN57H, ASN78H, ASN81H, ASN8H, ASN97H, ASP122E, ASP135E, ASP135H, ASP166E, ASP54H, ASP56E, ASP76H, ASP822H, ASP823H, ASP8E, GLN102E, GLN120H, GLN55H, GLN61H, GLN74H, GLN77H, GLN95H, GLU118E, GLU126E, GLU130H, GLU154H, GLU157E, GLU49E, GLU52H, GLU53H, GLU64E, GLU67H, GLU849E, GLY104E, GLY105E, GLY125E, GLY142H, GLY145H, GLY33E, GLY35H, GLY52E, GLY9H, HIS35E, HIS68H, ILE134E, ILE13H, ILE141H, ILE168E, ILE53E, ILE60H, ILE63H, ILE6E, ILE75H, ILE79H, ILE94H, ILE98H, LEU105H, LEU108H, LEU110E, LEU112E, LEU123E, LEU137E, LEU137H, LEU140H, LEU141E, LEU155E, LEU15H, LEU176E, LEU32E, LEU34H, LEU49H, LEU50E, LEU51H, LEU68E, LEU6H, LEU82H, LEU95E, LEU96E, LEU9E, LYS101H, LYS107H, LYS109E, LYS119E, LYS136E, LYS138E, LYS140E, LYS147H, LYS152E, LYS180E, LYS31E, LYS810H, LYS836E, MET164E, PHE100H, PHE11E, PHE129E, PHE12H, PHE130E, PHE143H, PHE146H, PHE14E, PHE150H, PHE158E, PHE16H, PHE170E, PHE28E, PHE33H, PHE34E, PHE36H, PHE48E, PHE66E, PHE7H, PRO100E, PRO124E, PRO128H, PRO136H, PRO149H, PRO67E, SER102H, SER103H, SER104H, SER10E, SER11H, SER122H, SER127H, SER133E, SER139H, SER13E, SER151E, SER169E, SER171E, SER172E, SER178E, SER54E, SER57E, SER59H, SER5E, SER5H, SER65E, SER69E, SER73H, SER7E, SER96H, THR10H, THR128E, THR12E, THR131E, THR133H, THR14H, THR160E, THR16E, THR37E, THR51E, THR83H, TRP62E, TYR101E, TYR173E, TYR29E, TYR98E, VAL106E, VAL107E, VAL127E, VAL134H, VAL152H, VAL156E, VAL15E, VAL167E, VAL58H, VAL72H
• E-I: ASN900E, ASP117I, ASP915E, ASP916E, GLN116I, GLU84I, LYS238I, LYS239I, LYS270I, LYS898E, SER114I
• E-L: ARG212L, ARG517E, ARG813E, ARG987E, ASP211L, ASP229L, ASP318L, ASP514E, GLN802E, GLU213L, GLU521E, GLU806E, GLU809E, SER219L, THR988E, TYR324L
• F-G: ALA132G, ALA139G, ALA151F, ALA17F, ALA69F, ALA776F, ALA808F, ALA844G, ALA845G, ALA850G, ALA94G, ALA99F, ARG111G, ARG38G, ARG80F, ASN114G, ASN120G, ASN121G, ASN148F, ASN153F, ASN17G, ASN56F, ASN57F, ASN783F, ASN78F, ASN800G, ASN81F, ASN8F, ASN97F, ASP122G, ASP135F, ASP135G, ASP166G, ASP54F, ASP56G, ASP76F, ASP781F, ASP822F, ASP823F, ASP841G, ASP8G, GLN102G, GLN120F, GLN55F, GLN61F, GLN74F, GLN777F, GLN77F, GLN802G, GLN805G, GLN95F, GLU118G, GLU126G, GLU130F, GLU154F, GLU157G, GLU49G, GLU52F, GLU53F, GLU64G, GLU67F, GLU779F, GLU806G, GLU809G, GLU815F, GLU824F, GLU849G, GLY104G, GLY105G, GLY125G, GLY142F, GLY145F, GLY33G, GLY35F, GLY52G, GLY772F, GLY848G, GLY853G, GLY9F, HIS35G, HIS68F, ILE134G, ILE13F, ILE141F, ILE168G, ILE53G, ILE60F, ILE63F, ILE6G, ILE75F, ILE773F, ILE782F, ILE799G, ILE79F, ILE808G, ILE817F, ILE820F, ILE821F, ILE843G, ILE846G, ILE847G, ILE94F, ILE98F, LEU105F, LEU108F, LEU112G, LEU123G, LEU137F, LEU137G, LEU140F, LEU141G, LEU155G, LEU15F, LEU176G, LEU32G, LEU34F, LEU49F, LEU50G, LEU51F, LEU68G, LEU6F, LEU775F, LEU778F, LEU801G, LEU812F, LEU82F, LEU842G, LEU941F, LEU95G, LEU96G, LEU9G, LYS101F, LYS107F, LYS109G, LYS119G, LYS136G, LYS138G, LYS140G, LYS147F, LYS152G, LYS180G, LYS31G, LYS786F, LYS810F, LYS836G, MET164G, MET780F, PHE100F, PHE11G, PHE129G, PHE12F, PHE130G, PHE143F, PHE146F, PHE14G, PHE150F, PHE158G, PHE16F, PHE170G, PHE28G, PHE33F, PHE34G, PHE36F, PHE48G, PHE66G, PHE7F, PRO100G, PRO124G, PRO128F, PRO136F, PRO149F, PRO18F, PRO67G, PRO798G, SER102F, SER103F, SER104F, SER10G, SER11F, SER122F, SER127F, SER133G, SER139F, SER13G, SER151G, SER169G, SER171G, SER172G, SER178G, SER54G, SER57G, SER59F, SER5F, SER5G, SER65G, SER69G, SER73F, SER774F, SER7G, SER809F, SER818F, SER835G, SER857G, SER96F, THR10F, THR128G, THR12G, THR131G, THR133F, THR14F, THR160G, THR16G, THR37G, THR51G, THR803G, THR813F, THR819F, THR839G, THR83F, TRP62G, TYR101G, TYR173G, TYR29G, TYR838G, TYR98G, VAL106G, VAL107G, VAL127G, VAL134F, VAL152F, VAL156G, VAL15G, VAL167G, VAL58F, VAL72F, VAL804G, VAL811F, VAL816F, VAL837G
• F-H: ALA615F, ALA649F, ALA655F, ARG616F, ASN148H, ASN647F, ASP648F, ASP650F, GLY145H, GLY652F, HIS617F, ILE651F, ILE654F, LEU614F, LYS147H, MET653F, PHE143H, PHE146H, PHE150H, PHE611F, PHE657F, PRO149H, SER612F, TYR656F, TYR688F
• F-K: ALA298K, ARG241F, ARG301K, ARG327K, ARG800F, ARG938F, ASP351K, ASP792F, ASP933F, GLU264K, GLU787F, GLU930F, HIS238F, LYS795F, MET780F, TYR209F
• G-H: ALA222G, ALA254H, ALA282G, ALA355H, ALA361H, ALA363H, ALA369H, ALA389G, ALA391G, ALA392G, ALA499G, ALA735H, ALA74G, ARG255H, ARG283G, ARG351H, ARG354H, ARG368H, ARG377H, ARG379G, ARG396G, ARG421H, ARG424H, ARG460H, ARG469H, ARG487G, ARG490G, ARG496G, ARG571H, ARG621H, ARG635G, ARG643H, ARG739H, ARG763G, ARG78G, ARG858G, ASN197H, ASN226G, ASN250H, ASN687H, ASP192H, ASP221G, ASP350H, ASP357H, ASP360H, ASP388G, ASP485G, ASP727H, GLN495G, GLN757G, GLN867G, GLU219H, GLU222H, GLU246H, GLU248G, GLU373H, GLU378G, GLU382G, GLU64G, GLU659H, GLU724H, GLU856G, GLU86G, GLU93G, GLY191H, GLY219G, GLY220G, GLY247H, GLY248H, GLY252H, GLY275G, GLY276G, GLY280G, GLY376H, GLY471H, GLY492G, GLY497G, GLY498G, GLY842H, HIS35G, HIS366H, HIS394G, HIS466H, HIS493G, HIS617H, HIS838H, HIS864G, ILE251H, ILE274G, ILE278G, ILE279G, ILE332H, ILE352H, ILE356H, ILE359H, ILE371H, ILE387G, ILE427H, ILE488G, LEU244H, LEU383G, LEU491G, LYS425H, LYS453G, LYS660H, LYS797H, LYS832H, LYS869G, MET196H, MET375H, MET403G, PHE370H, PHE398G, PHE48G, PRO194H, PRO223G, SER193H, SER273G, SER347H, SER365H, SER393G, SER395G, SER39G, SER622H, SER732H, THR217G, THR249H, THR253H, THR277G, THR281G, THR362H, THR390G, THR462H, THR463H, THR489G, THR661G, THR668G, TYR358H, TYR386G, VAL245H, VAL372H, VAL494G
• G-J: ALA901G, ASN900G, ASP117J, ASP915G, ASP916G, GLN116J, GLU84J, HIS899G, LYS238J, LYS239J, LYS270J, LYS898G, SER114J, TYR78J
• G-K: ARG212K, ARG517G, ARG813G, ARG987G, ASP211K, ASP229K, ASP318K, ASP514G, GLN802G, GLU213K, GLU521G, GLU806G, GLU809G, SER219K, THR988G, TYR324K
• H-L: ALA298L, ARG241H, ARG301L, ARG327L, ARG800H, ARG938H, ASN329L, ASP351L, ASP792H, ASP933H, GLU264L, GLU779H, GLU787H, GLU930H, GLY937H, HIS238H, LYS323L, LYS795H, MET780H, TYR209H