3OPV

crystal structure of e. coli purine nucleoside phosphorylase arg24ala mutant

• Total interactions analyzed: 66
• Total true interactions: 35
• Strongest Interaction:
  • Chains: B-D
  • Int. Res.: 147
  • Norm. En. per Res.: -5.1719
• Hub Node: A(7)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	0.0	5.7863	-14.4196	-8.6333	17	1	0	637	0	13	18
A-C	0.0	5.8301	-15.4507	-9.6206	17	1	0	643	0	13	17
A-D	-5.9822	-1.8612	-377.01	-384.8533	139	13	6	16509	0	54	32
A-F	-96.0733	-136.9443	-496.809	-729.8266	147	24	19	17926	13	68	62
A-H	0.0	-10.2503	-19.2365	-29.4868	25	0	0	1001	0	18	14
A-I	-7.0629	-4.2589	-9.0198	-20.3417	18	1	0	571	1	14	15
A-K	0.0	14.0412	-1.0819	12.9593	17	0	0	139	0	8	8
B-C	0.0	6.438	-15.8064	-9.3684	17	1	0	658	0	13	17
B-D	-95.2289	-152.4156	-512.628	-760.2725	147	30	20	18163	15	69	62
B-E	-6.0088	-2.3623	-364.213	-372.5841	136	7	5	16291	0	54	31
B-G	0.0	-24.4831	-49.1274	-73.6105	33	0	0	2276	0	19	20
B-J	-7.2969	-15.0977	-76.6866	-99.0812	41	5	0	3154	0	22	22
C-E	-96.3814	-109.5024	-505.534	-711.4178	146	34	20	17865	13	66	60
C-F	-8.8503	0.8825	-385.908	-393.8758	137	7	5	16578	0	54	33
C-G	0.0	5.7683	-2.7153	3.0531	15	0	0	411	0	14	14
C-L	-6.1256	-9.7803	-46.8595	-62.7654	34	1	0	1954	1	21	20
D-E	-4.0209	4.8726	-11.2043	-10.3527	16	1	0	632	0	13	17
D-F	-4.7186	6.5148	-14.8374	-13.0412	18	1	0	625	0	13	17
D-H	-12.3994	10.3575	-66.5192	-68.5611	39	4	0	2856	0	21	17
E-F	-5.5044	5.9486	-15.8333	-15.3891	18	1	0	666	0	13	17
E-G	0.0	31.0122	-10.0971	20.9151	23	0	0	653	0	10	9
F-I	0.0	-6.0754	-12.568	-18.6434	32	3	0	1681	0	17	16
F-L	0.0	0.0	-0.0624	-0.0624	4	0	0	21	0	0	2
G-H	0.0	5.1177	-10.6085	-5.4908	17	1	0	600	0	13	17
G-I	-4.8237	6.4126	-15.17	-13.581	17	1	0	620	0	13	17
G-J	-7.7381	1.1633	-379.059	-385.6338	135	11	5	16458	0	54	31
G-L	-112.9201	-108.8451	-496.188	-717.9532	148	44	20	17753	12	68	62
H-I	0.0	5.4823	-14.4918	-9.0095	17	1	0	643	0	13	17
H-J	-90.7058	-148.8866	-508.278	-747.8704	146	32	20	18013	11	70	62
H-K	-5.0593	-2.5883	-381.905	-389.5526	136	10	6	16444	0	53	30
I-K	-90.4588	-134.7937	-516.967	-742.2194	145	26	20	17967	12	69	61
I-L	-7.978	0.0008	-379.809	-387.7862	134	9	6	16415	0	53	31
J-K	0.0	7.339	-14.0823	-6.7433	18	1	0	647	0	13	17
J-L	-3.6679	5.0475	-12.6123	-11.2327	17	0	0	610	0	13	17
K-L	-4.5995	5.2816	-14.7761	-14.094	17	1	0	639	0	13	17

Interface residues

• A-B: ARG117A, ARG117B, ASP122A, ASP122B, ASP124B, ASP163A, HIS123B, ILE118A, LEU158A, LYS114A, LYS121B, LYS172B, PHE120B, PRO162A, SER161A, TYR173B, VAL115A
• A-C: ARG117A, ARG117C, ASP122A, ASP122C, ASP124A, ASP163C, HIS123A, ILE118C, LEU158C, LYS114C, LYS121A, LYS172A, PHE120A, PRO162C, SER161C, TYR173A, VAL115C
• A-D: ALA156A, ALA156D, ALA24A, ALA24D, ALA25A, ARG117A, ARG117D, ARG119A, ARG119D, ARG217A, ARG43A, ARG43D, ARG87A, ARG87D, ASN116A, ASN116D, ASN41A, ASN41D, ASP112A, ASP112D, ASP122A, ASP122D, ASP157A, ASP157D, ASP163A, ASP163D, ASP204D, ASP21A, ASP21D, ASP79A, ASP79D, CYS69A, CYS69D, GLN211A, GLN211D, GLU181A, GLU181D, GLU191A, GLU191D, GLU75A, GLU75D, GLY184A, GLY184D, GLY187A, GLY187D, GLY20A, GLY20D, GLY44A, GLY44D, GLY61A, GLY61D, GLY63A, GLY63D, GLY65A, GLY65D, GLY89A, GLY89D, HIS4A, HIS4D, HIS62A, HIS62D, ILE118A, ILE118D, ILE5A, ILE5D, ILE66A, ILE66D, ILE71A, ILE71D, LEU158A, LEU158D, LEU23A, LEU23D, LEU46A, LEU46D, LEU76A, LEU76D, LYS114A, LYS114D, LYS121A, LYS121D, LYS74A, LYS74D, MET166A, MET166D, MET180A, MET180D, MET45A, MET45D, MET60A, MET60D, MET64A, MET64D, PHE120A, PHE120D, PHE154A, PHE154D, PHE159A, PHE159D, PHE192A, PHE192D, PRO162A, PRO162D, PRO19A, PRO19D, PRO22A, PRO22D, PRO3A, PRO3D, PRO67A, PRO67D, SER113A, SER113D, SER161A, SER161D, SER68A, SER68D, SER70A, SER70D, SER90A, SER90D, THR111A, THR111D, THR2A, THR2D, THR73A, THR73D, THR78A, THR78D, TYR160A, TYR160D, TYR72A, TYR72D, VAL115A, VAL115D, VAL188A, VAL188D, VAL42A, VAL42D
• A-F: ALA109A, ALA109F, ALA126A, ALA126F, ALA127A, ALA127F, ALA129A, ALA129F, ALA137A, ALA137F, ALA140F, ALA148A, ALA148F, ALA183A, ALA183F, ALA189A, ALA189F, ALA190A, ALA190F, ARG117A, ARG117F, ARG119A, ARG119F, ARG135A, ARG135F, ARG149A, ARG149F, ASN116A, ASN116F, ASN136A, ASN136F, ASN152A, ASN152F, ASP112A, ASP112F, ASP122A, ASP122F, ASP124A, ASP124F, ASP130A, ASP130F, ASP132A, ASP132F, ASP139A, ASP139F, ASP157A, ASP157F, ASP163A, ASP163F, ASP168A, ASP168F, CYS110A, CYS110F, GLU165A, GLU165F, GLU171A, GLU171F, GLU191A, GLU191F, GLY106A, GLY106F, GLY108A, GLY108F, GLY151A, GLY151F, GLY164A, GLY164F, GLY174A, GLY174F, GLY187A, GLY187F, GLY193A, GLY193F, HIS123A, HIS123F, ILE105A, ILE105F, ILE118A, ILE118F, ILE128A, ILE128F, ILE175A, ILE175F, LEU153A, LEU153F, LEU176A, LEU176F, LYS114A, LYS114F, LYS121A, LYS121F, LYS142A, LYS142F, LYS172A, LYS172F, LYS195F, LYS237A, LYS237F, MET107A, MET107F, MET133A, MET133F, MET166A, MET166F, MET170A, MET170F, PHE120A, PHE120F, PHE125A, PHE125F, PHE131A, PHE131F, PHE154A, PHE154F, PHE167A, PHE167F, PHE192A, PHE192F, PRO162F, SER113A, SER113F, SER155A, SER155F, SER161A, SER161F, THR111A, THR111F, TYR173A, TYR173F, TYR186A, TYR186F, VAL115A, VAL115F, VAL134A, VAL134F, VAL138A, VAL138F, VAL150A, VAL150F, VAL169A, VAL169F, VAL178A, VAL178F, VAL188A, VAL188F, VAL94A, VAL94F
• A-H: ALA214A, ARG207A, ARG207H, ASP163H, ASP168H, ASP204H, GLN211A, GLN211H, GLU165H, GLU210A, GLY164H, HIS205A, HIS205H, HIS209A, HIS209H, ILE206A, ILE206H, MET166H, PHE167H, PRO162H, SER161H, THR208A, THR208H, THR212A, TYR160H
• A-I: ARG207A, ARG207I, ASP168A, ASP168I, GLU165I, GLU171A, GLU171I, HIS205I, HIS97A, HIS97I, LEU95A, LEU95I, LYS172I, PRO96A, PRO96I, THR208A, VAL169I, VAL94I
• A-K: ALA1K, ALA215A, ARG101A, ASP79K, GLN211A, GLU191K, GLU210A, GLU216A, LYS74K, MET9K, PHE192K, PRO3K, THR208A, THR212A, THR213A, THR2K, THR78K
• B-C: ARG117B, ARG117C, ASP122B, ASP122C, ASP124C, ASP163B, HIS123C, ILE118B, LEU158B, LYS114B, LYS121C, LYS172C, PHE120C, PRO162B, SER161B, TYR173C, VAL115B
• B-D: ALA109B, ALA109D, ALA126B, ALA126D, ALA127B, ALA127D, ALA129B, ALA129D, ALA137B, ALA137D, ALA148D, ALA183B, ALA183D, ALA189B, ALA189D, ALA190B, ALA190D, ALA196B, ARG117B, ARG117D, ARG119B, ARG119D, ARG135B, ARG135D, ARG149B, ARG149D, ASN116B, ASN116D, ASN136B, ASN136D, ASN152B, ASN152D, ASP112B, ASP112D, ASP122B, ASP122D, ASP124B, ASP124D, ASP130B, ASP130D, ASP132B, ASP132D, ASP139B, ASP139D, ASP157B, ASP157D, ASP163B, ASP163D, ASP168B, ASP168D, CYS110B, CYS110D, GLU165B, GLU165D, GLU171B, GLU171D, GLU191B, GLU191D, GLY106B, GLY106D, GLY108B, GLY108D, GLY151B, GLY151D, GLY164B, GLY164D, GLY174B, GLY174D, GLY187B, GLY187D, GLY193B, GLY193D, HIS123B, HIS123D, ILE105B, ILE105D, ILE118B, ILE118D, ILE128B, ILE128D, ILE175B, ILE175D, LEU153B, LEU153D, LEU176B, LEU176D, LYS114B, LYS114D, LYS121B, LYS121D, LYS142B, LYS142D, LYS172B, LYS172D, LYS195B, LYS237B, LYS237D, MET107B, MET107D, MET133B, MET133D, MET166B, MET166D, MET170B, MET170D, PHE120B, PHE120D, PHE125B, PHE125D, PHE131B, PHE131D, PHE154B, PHE154D, PHE167B, PHE167D, PHE192B, PHE192D, PRO162B, PRO162D, SER113B, SER113D, SER155B, SER155D, SER161B, SER161D, THR111B, THR111D, TYR173B, TYR173D, TYR186B, TYR186D, VAL115B, VAL115D, VAL134B, VAL134D, VAL138B, VAL138D, VAL150B, VAL150D, VAL169B, VAL169D, VAL178B, VAL178D, VAL188B, VAL188D, VAL94B, VAL94D
• B-E: ALA156B, ALA156E, ALA24B, ALA24E, ALA25B, ARG117B, ARG117E, ARG119B, ARG119E, ARG43B, ARG43E, ARG87B, ARG87E, ASN116B, ASN116E, ASN40E, ASN41B, ASN41E, ASP112B, ASP112E, ASP122B, ASP122E, ASP157B, ASP157E, ASP163B, ASP163E, ASP21B, ASP21E, ASP79B, ASP79E, CYS69B, CYS69E, GLU181B, GLU181E, GLU191B, GLU191E, GLU75B, GLU75E, GLY184B, GLY184E, GLY187B, GLY187E, GLY20B, GLY20E, GLY44B, GLY44E, GLY61B, GLY61E, GLY63B, GLY63E, GLY65B, GLY65E, GLY89B, GLY89E, HIS209B, HIS4B, HIS4E, HIS62B, HIS62E, ILE118B, ILE118E, ILE5B, ILE5E, ILE66B, ILE66E, ILE71B, ILE71E, LEU158B, LEU158E, LEU23B, LEU23E, LEU46B, LEU46E, LEU76B, LEU76E, LYS114B, LYS114E, LYS121B, LYS74B, LYS74E, MET166B, MET166E, MET180B, MET180E, MET45B, MET45E, MET60B, MET60E, MET64B, MET64E, PHE120B, PHE120E, PHE154B, PHE154E, PHE159B, PHE159E, PHE192B, PHE192E, PRO162B, PRO162E, PRO19B, PRO19E, PRO22B, PRO22E, PRO3B, PRO3E, PRO67B, PRO67E, SER113B, SER113E, SER161B, SER161E, SER68B, SER68E, SER70B, SER70E, SER90B, SER90E, THR111B, THR111E, THR2B, THR2E, THR73B, THR73E, THR78B, THR78E, TYR160B, TYR160E, TYR72B, TYR72E, VAL115B, VAL115E, VAL188B, VAL188E, VAL42B, VAL42E
• B-G: ALA214G, ARG207B, ARG207G, ARG217G, ASP163B, ASP168B, ASP204B, ASP204G, GLN211B, GLN211G, GLU165B, GLU210B, GLU210G, GLY164B, GLY92G, HIS205G, HIS209B, HIS209G, ILE206B, ILE206G, MET166B, PHE159B, PHE159G, PHE167B, PRO162B, SER161B, SER203G, THR208B, THR208G, THR212G, THR213G, TYR160B, TYR160G
• B-J: ALA1J, ALA7J, ARG101B, ARG149B, ARG207B, ASN41J, ASN6J, ASP102B, ASP11J, ASP204B, ASP79J, GLN211B, GLU171B, GLU210B, GLU216B, GLU75J, GLU8J, GLY10J, GLY81J, HIS205B, HIS209B, HIS4J, HIS97B, ILE5J, ILE77J, LEU100B, LEU76J, LEU95B, LYS74J, LYS99B, MET9J, PHE80J, PRO3J, PRO96B, THR208B, THR2J, THR78J, VAL202B, VAL42J, VAL82J, VAL98B
• C-E: ALA109C, ALA109E, ALA126C, ALA126E, ALA127C, ALA127E, ALA129C, ALA129E, ALA137C, ALA137E, ALA140E, ALA148C, ALA183C, ALA183E, ALA189C, ALA189E, ALA190C, ALA190E, ALA196C, ALA196E, ARG117C, ARG117E, ARG119C, ARG119E, ARG135C, ARG135E, ARG149C, ARG149E, ASN116C, ASN116E, ASN136C, ASN136E, ASN152C, ASN152E, ASP112C, ASP112E, ASP122C, ASP122E, ASP124C, ASP124E, ASP130C, ASP130E, ASP132C, ASP132E, ASP139C, ASP139E, ASP157C, ASP157E, ASP163C, ASP163E, ASP168C, ASP168E, CYS110C, CYS110E, GLU165C, GLU165E, GLU171C, GLU171E, GLU191C, GLU191E, GLY106C, GLY106E, GLY108C, GLY108E, GLY151C, GLY151E, GLY164C, GLY164E, GLY174C, GLY174E, GLY187C, GLY187E, GLY193C, GLY193E, HIS123C, HIS123E, ILE105C, ILE105E, ILE118C, ILE118E, ILE128C, ILE128E, ILE175C, ILE175E, LEU153C, LEU153E, LEU176C, LEU176E, LEU197E, LEU234E, LYS114C, LYS114E, LYS121C, LYS121E, LYS142C, LYS142E, LYS172C, LYS172E, LYS237C, MET107C, MET107E, MET133C, MET133E, MET166C, MET166E, MET170C, MET170E, PHE120C, PHE120E, PHE125C, PHE125E, PHE131C, PHE131E, PHE154C, PHE154E, PHE167C, PHE167E, PHE192C, PHE192E, PRO162C, SER113C, SER113E, SER155C, SER155E, SER161C, SER161E, THR111C, THR111E, TYR173C, TYR173E, TYR186C, TYR186E, VAL115C, VAL115E, VAL134C, VAL134E, VAL138C, VAL138E, VAL150C, VAL150E, VAL169C, VAL169E, VAL178E, VAL188C, VAL188E, VAL94E
• C-F: ALA156C, ALA156F, ALA24C, ALA24F, ALA25C, ALA25F, ARG117C, ARG117F, ARG119C, ARG119F, ARG43C, ARG43F, ARG87C, ARG87F, ASN116C, ASN116F, ASN41C, ASN41F, ASP112C, ASP112F, ASP122C, ASP122F, ASP157C, ASP157F, ASP163C, ASP163F, ASP21C, ASP21F, ASP79C, ASP79F, CYS69C, CYS69F, GLN211C, GLU181C, GLU181F, GLU191C, GLU191F, GLU75C, GLU75F, GLY184C, GLY184F, GLY187C, GLY187F, GLY20C, GLY20F, GLY44C, GLY44F, GLY61C, GLY61F, GLY63C, GLY63F, GLY65C, GLY65F, GLY89C, GLY89F, HIS4C, HIS4F, HIS62C, HIS62F, ILE118C, ILE118F, ILE5C, ILE5F, ILE66C, ILE66F, ILE71C, ILE71F, LEU158C, LEU158F, LEU23C, LEU23F, LEU46C, LEU46F, LEU76C, LEU76F, LYS114C, LYS114F, LYS121C, LYS121F, LYS74C, LYS74F, MET166C, MET166F, MET180C, MET180F, MET45C, MET45F, MET60C, MET60F, MET64C, MET64F, PHE120C, PHE120F, PHE154C, PHE154F, PHE159C, PHE159F, PHE192C, PHE192F, PRO162C, PRO162F, PRO19C, PRO19F, PRO22C, PRO22F, PRO3C, PRO3F, PRO67C, PRO67F, SER113C, SER113F, SER161C, SER161F, SER203C, SER68C, SER68F, SER70C, SER70F, SER90C, SER90F, THR111C, THR111F, THR2C, THR2F, THR73C, THR78C, THR78F, TYR160C, TYR160F, TYR72C, TYR72F, VAL115C, VAL115F, VAL188C, VAL188F, VAL42C, VAL42F
• C-G: ARG207C, ARG207G, ASP168C, ASP168G, GLU165C, GLU171C, GLU171G, GLU210G, HIS205G, HIS97G, LYS172C, PRO96C, PRO96G, THR208G, VAL169C
• C-L: ALA194L, ALA214C, ARG207C, ARG217C, ARG37L, ASP11L, ASP14L, ASP204C, ASP79L, GLN211C, GLU191L, GLU210C, GLU8L, GLY10L, GLY193L, GLY81L, HIS205C, HIS209C, ILE77L, LEU100C, LEU76L, LYS195L, LYS56L, LYS83L, LYS99C, MET9L, PHE192L, PHE80L, PRO96C, THR208C, THR212C, THR213C, THR78L, VAL82L
• D-E: ARG117D, ARG117E, ASP122D, ASP122E, ASP124D, ASP163E, HIS123D, ILE118E, LEU158E, LYS114E, LYS121D, LYS172D, PHE120D, PRO162E, TYR173D, VAL115E
• D-F: ARG117D, ARG117F, ASP122D, ASP122F, ASP124F, ASP163D, HIS123F, ILE118D, LEU158D, LYS114D, LYS121D, LYS121F, LYS172F, PHE120F, PRO162D, SER161D, TYR173F, VAL115D
• D-H: ALA1D, ALA7D, ARG101H, ARG149H, ARG207H, ASN6D, ASP102H, ASP11D, ASP204H, ASP79D, GLN211H, GLU171H, GLU210H, GLU75D, GLU8D, GLY10D, GLY81D, HIS205H, HIS209H, HIS4D, HIS97H, ILE5D, ILE77D, LEU100H, LEU76D, LEU95H, LYS74D, LYS99H, MET9D, PHE80D, PRO3D, PRO96H, THR208H, THR2D, THR78D, VAL202H, VAL42D, VAL82D, VAL98H
• E-F: ARG117E, ARG117F, ASP122E, ASP122F, ASP124E, ASP163F, HIS123E, ILE118F, LEU158F, LYS114F, LYS121E, LYS121F, LYS172E, PHE120E, PRO162F, SER161F, TYR173E, VAL115F
• E-G: ALA1E, ALA214G, ALA215G, ARG101G, ASP79E, GLN211G, GLU191E, GLU210G, GLU216G, GLU75E, GLU8E, HIS4E, LEU100G, LYS74E, MET9E, PHE192E, PHE80E, PRO3E, THR208G, THR212G, THR213G, THR2E, THR78E
• F-I: ALA13F, ALA194F, ARG207I, ARG217I, ASP11F, ASP14F, ASP204I, ASP79F, GLN211I, GLU210I, GLU8F, GLY10F, GLY193F, GLY81F, HIS205I, HIS209I, ILE77F, LEU100I, LEU76F, LYS56F, LYS83F, LYS99I, MET9F, PHE12F, PHE192F, PHE80F, THR208I, THR212I, THR213I, THR78F, VAL15F, VAL82F
• F-L: ALA1F, ALA1L, GLU8F, GLU8L
• G-H: ARG117G, ARG117H, ASP122G, ASP122H, ASP124H, ASP163G, HIS123H, ILE118G, LEU158G, LYS114G, LYS121H, LYS172H, PHE120H, PRO162G, SER161G, TYR173H, VAL115G
• G-I: ARG117G, ARG117I, ASP122G, ASP122I, ASP124G, ASP163I, HIS123G, ILE118I, LEU158I, LYS114I, LYS121G, LYS172G, PHE120G, PRO162I, SER161I, TYR173G, VAL115I
• G-J: ALA156G, ALA156J, ALA24G, ALA24J, ALA25G, ARG117G, ARG117J, ARG119G, ARG119J, ARG43G, ARG43J, ARG87G, ARG87J, ASN116G, ASN116J, ASN40J, ASN41G, ASN41J, ASP112G, ASP112J, ASP122G, ASP122J, ASP157G, ASP157J, ASP163G, ASP163J, ASP21G, ASP21J, ASP79G, ASP79J, CYS69G, CYS69J, GLU181G, GLU181J, GLU191G, GLU191J, GLU75G, GLU75J, GLY184G, GLY184J, GLY187G, GLY187J, GLY20G, GLY20J, GLY44G, GLY44J, GLY61G, GLY61J, GLY63G, GLY63J, GLY65G, GLY65J, GLY89G, GLY89J, HIS4G, HIS4J, HIS62G, HIS62J, ILE118G, ILE118J, ILE5G, ILE5J, ILE66G, ILE66J, ILE71G, ILE71J, LEU158G, LEU158J, LEU23G, LEU23J, LEU46G, LEU46J, LEU76G, LEU76J, LYS114G, LYS114J, LYS121G, LYS121J, LYS74G, LYS74J, MET166G, MET166J, MET180G, MET180J, MET45G, MET45J, MET60G, MET64G, MET64J, PHE120G, PHE120J, PHE154G, PHE154J, PHE159G, PHE159J, PHE192G, PHE192J, PRO162G, PRO162J, PRO19G, PRO19J, PRO22G, PRO22J, PRO3G, PRO3J, PRO67G, PRO67J, SER113G, SER113J, SER161G, SER161J, SER68G, SER68J, SER70G, SER70J, SER90G, SER90J, THR111G, THR111J, THR2G, THR2J, THR73G, THR73J, THR78G, THR78J, TYR160G, TYR160J, TYR72G, TYR72J, VAL115G, VAL115J, VAL188G, VAL188J, VAL42G, VAL42J
• G-L: ALA109G, ALA109L, ALA126G, ALA126L, ALA127G, ALA127L, ALA129G, ALA129L, ALA137G, ALA137L, ALA140L, ALA148G, ALA148L, ALA183G, ALA183L, ALA189G, ALA189L, ALA190G, ALA190L, ALA196G, ALA196L, ARG117G, ARG117L, ARG119G, ARG119L, ARG135G, ARG135L, ARG149G, ARG149L, ASN116G, ASN116L, ASN136G, ASN136L, ASN152G, ASN152L, ASP112G, ASP112L, ASP122G, ASP122L, ASP124G, ASP124L, ASP130G, ASP130L, ASP132G, ASP132L, ASP139G, ASP139L, ASP157G, ASP157L, ASP163G, ASP163L, ASP168G, ASP168L, CYS110G, CYS110L, GLU165G, GLU165L, GLU171G, GLU171L, GLU191G, GLU191L, GLY106G, GLY106L, GLY108G, GLY108L, GLY151G, GLY151L, GLY164G, GLY164L, GLY174G, GLY174L, GLY187G, GLY187L, GLY193G, GLY193L, HIS123G, HIS123L, ILE105G, ILE105L, ILE118G, ILE118L, ILE128G, ILE128L, ILE175G, ILE175L, LEU153G, LEU153L, LEU176G, LEU176L, LEU234L, LYS114G, LYS114L, LYS121G, LYS121L, LYS142G, LYS142L, LYS172G, LYS172L, LYS195G, LYS237L, MET107G, MET107L, MET133G, MET133L, MET166G, MET166L, MET170G, MET170L, PHE120G, PHE120L, PHE125G, PHE125L, PHE131G, PHE131L, PHE154G, PHE154L, PHE167G, PHE167L, PHE192G, PHE192L, PRO162G, PRO162L, SER113G, SER113L, SER155G, SER155L, SER161G, SER161L, THR111G, THR111L, TYR173G, TYR173L, TYR186G, TYR186L, VAL115G, VAL115L, VAL134G, VAL134L, VAL138G, VAL138L, VAL150G, VAL150L, VAL169G, VAL169L, VAL178G, VAL178L, VAL188G, VAL188L
• H-I: ARG117H, ARG117I, ASP122H, ASP122I, ASP124I, ASP163H, HIS123I, ILE118H, LEU158H, LYS114H, LYS121I, LYS172I, PHE120I, PRO162H, SER161H, TYR173I, VAL115H
• H-J: ALA109H, ALA109J, ALA126H, ALA126J, ALA127H, ALA127J, ALA129H, ALA129J, ALA137H, ALA137J, ALA148H, ALA148J, ALA156J, ALA183H, ALA183J, ALA189H, ALA189J, ALA190H, ALA190J, ALA196H, ARG117H, ARG117J, ARG119H, ARG119J, ARG135H, ARG135J, ARG149H, ARG149J, ASN116H, ASN116J, ASN136H, ASN136J, ASN152H, ASN152J, ASP112H, ASP112J, ASP122H, ASP122J, ASP124H, ASP124J, ASP130H, ASP130J, ASP132H, ASP132J, ASP139H, ASP139J, ASP157J, ASP163H, ASP163J, ASP168H, ASP168J, CYS110H, CYS110J, GLU165H, GLU165J, GLU171H, GLU171J, GLU191H, GLU191J, GLY106H, GLY106J, GLY108H, GLY108J, GLY151H, GLY151J, GLY164H, GLY164J, GLY174H, GLY174J, GLY187H, GLY187J, GLY193H, GLY193J, HIS123H, HIS123J, ILE105H, ILE105J, ILE118H, ILE118J, ILE128H, ILE128J, ILE175H, ILE175J, LEU153H, LEU153J, LEU176H, LEU176J, LYS114H, LYS114J, LYS121H, LYS121J, LYS142H, LYS142J, LYS172H, LYS172J, LYS195H, LYS237H, LYS237J, MET107H, MET107J, MET133H, MET133J, MET166H, MET166J, MET170H, MET170J, PHE120H, PHE120J, PHE125H, PHE125J, PHE131H, PHE131J, PHE154H, PHE154J, PHE167H, PHE167J, PHE192H, PHE192J, PRO162J, SER113H, SER113J, SER155H, SER155J, SER161H, SER161J, THR111H, THR111J, TYR173H, TYR173J, TYR186H, TYR186J, VAL115H, VAL115J, VAL134H, VAL134J, VAL138H, VAL138J, VAL150H, VAL150J, VAL169H, VAL169J, VAL178H, VAL178J, VAL188H, VAL188J, VAL94J
• H-K: ALA156H, ALA156K, ALA24H, ALA24K, ALA25K, ARG117H, ARG117K, ARG119H, ARG119K, ARG43H, ARG43K, ARG87H, ARG87K, ASN116H, ASN116K, ASN41H, ASN41K, ASP112H, ASP112K, ASP122H, ASP122K, ASP157H, ASP157K, ASP163H, ASP163K, ASP21H, ASP21K, ASP79H, ASP79K, CYS69H, CYS69K, GLU181H, GLU181K, GLU191H, GLU191K, GLU75H, GLU75K, GLY184H, GLY184K, GLY187H, GLY187K, GLY20H, GLY20K, GLY44H, GLY44K, GLY61H, GLY61K, GLY63H, GLY63K, GLY65H, GLY65K, GLY89H, GLY89K, HIS4H, HIS4K, HIS62H, HIS62K, ILE118H, ILE118K, ILE5H, ILE5K, ILE66H, ILE66K, ILE71H, ILE71K, LEU158H, LEU158K, LEU23H, LEU23K, LEU46H, LEU46K, LEU76H, LEU76K, LYS114H, LYS114K, LYS121H, LYS121K, LYS74H, LYS74K, MET166H, MET166K, MET180H, MET180K, MET45H, MET45K, MET60H, MET60K, MET64H, MET64K, PHE120H, PHE120K, PHE154H, PHE154K, PHE159H, PHE159K, PHE192H, PHE192K, PRO162H, PRO162K, PRO19H, PRO19K, PRO22H, PRO22K, PRO3H, PRO3K, PRO67H, PRO67K, SER113H, SER113K, SER161H, SER161K, SER203K, SER68H, SER68K, SER70H, SER70K, SER90H, SER90K, THR111H, THR111K, THR2H, THR2K, THR73H, THR73K, THR78H, THR78K, TYR160H, TYR160K, TYR72H, TYR72K, VAL115H, VAL115K, VAL188H, VAL188K, VAL42H, VAL42K
• I-K: ALA109I, ALA109K, ALA126I, ALA126K, ALA127I, ALA127K, ALA129I, ALA129K, ALA137I, ALA137K, ALA148I, ALA183I, ALA183K, ALA189I, ALA189K, ALA190I, ALA190K, ALA196I, ALA196K, ARG117I, ARG117K, ARG119I, ARG119K, ARG135I, ARG135K, ARG149I, ARG149K, ASN116I, ASN116K, ASN136I, ASN136K, ASN152I, ASN152K, ASP112I, ASP112K, ASP122I, ASP122K, ASP124I, ASP124K, ASP130I, ASP130K, ASP132I, ASP132K, ASP139I, ASP139K, ASP157I, ASP157K, ASP163I, ASP163K, ASP168I, ASP168K, CYS110I, CYS110K, GLU165I, GLU165K, GLU171I, GLU171K, GLU191I, GLU191K, GLY106I, GLY106K, GLY108I, GLY108K, GLY151I, GLY151K, GLY164I, GLY164K, GLY174I, GLY174K, GLY187I, GLY187K, GLY193I, GLY193K, HIS123I, HIS123K, ILE105I, ILE105K, ILE118I, ILE118K, ILE128I, ILE128K, ILE175I, ILE175K, LEU153I, LEU153K, LEU176I, LEU176K, LEU197K, LYS114I, LYS114K, LYS121I, LYS121K, LYS142I, LYS142K, LYS172I, LYS172K, LYS237K, MET107I, MET107K, MET133I, MET133K, MET166I, MET166K, MET170I, MET170K, PHE120I, PHE120K, PHE125I, PHE125K, PHE131I, PHE131K, PHE154I, PHE154K, PHE167I, PHE167K, PHE192I, PHE192K, PRO162K, SER113I, SER113K, SER155I, SER155K, SER161I, SER161K, THR111I, THR111K, TYR173I, TYR173K, TYR186I, TYR186K, VAL115I, VAL115K, VAL134I, VAL134K, VAL138I, VAL138K, VAL150I, VAL150K, VAL169I, VAL169K, VAL178I, VAL178K, VAL188I, VAL188K, VAL94I
• I-L: ALA156I, ALA156L, ALA24I, ALA24L, ARG117I, ARG117L, ARG119I, ARG119L, ARG43I, ARG43L, ARG87I, ARG87L, ASN116I, ASN116L, ASN41I, ASN41L, ASP112I, ASP112L, ASP122I, ASP122L, ASP157I, ASP157L, ASP163I, ASP163L, ASP21I, ASP21L, ASP79I, ASP79L, CYS69I, CYS69L, GLU181I, GLU181L, GLU191I, GLU191L, GLU75I, GLU75L, GLY184I, GLY184L, GLY187I, GLY187L, GLY20I, GLY20L, GLY44I, GLY44L, GLY61I, GLY61L, GLY63I, GLY63L, GLY65I, GLY65L, GLY89I, GLY89L, HIS4I, HIS4L, HIS62I, HIS62L, ILE118I, ILE118L, ILE5I, ILE5L, ILE66I, ILE66L, ILE71I, ILE71L, LEU158I, LEU158L, LEU23I, LEU23L, LEU46I, LEU46L, LEU76I, LEU76L, LYS114I, LYS114L, LYS121L, LYS74I, LYS74L, MET166I, MET166L, MET180I, MET180L, MET45I, MET45L, MET60I, MET60L, MET64I, MET64L, PHE120I, PHE120L, PHE154I, PHE154L, PHE159I, PHE159L, PHE192I, PHE192L, PRO162I, PRO162L, PRO19I, PRO19L, PRO22I, PRO22L, PRO3I, PRO3L, PRO67I, PRO67L, SER113I, SER113L, SER161I, SER161L, SER203L, SER68I, SER68L, SER70I, SER70L, SER90I, SER90L, THR111I, THR111L, THR2I, THR2L, THR73I, THR73L, THR78I, THR78L, TYR160I, TYR160L, TYR72I, TYR72L, VAL115I, VAL115L, VAL188I, VAL188L, VAL42I, VAL42L
• J-K: ARG117J, ARG117K, ASP122J, ASP122K, ASP124J, ASP163K, HIS123J, ILE118K, LEU158K, LYS114K, LYS121J, LYS121K, LYS172J, PHE120J, PRO162K, SER161K, TYR173J, VAL115K
• J-L: ARG117J, ARG117L, ASP122J, ASP122L, ASP124L, ASP163J, HIS123L, ILE118J, LEU158J, LYS114J, LYS121J, LYS121L, LYS172L, PHE120L, PRO162J, TYR173L, VAL115J
• K-L: ARG117K, ARG117L, ASP122K, ASP122L, ASP124K, ASP163L, HIS123K, ILE118L, LEU158L, LYS114L, LYS121K, LYS172K, PHE120K, PRO162L, SER161L, TYR173K, VAL115L