3OP0

crystal structure of cbl-c (cbl-3) tkb domain in complex with egfr py1069 peptide

• Total interactions analyzed: 6
• Total true interactions: 3
• Strongest Interaction:
  • Chains: B-D
  • Int. Res.: 50
  • Norm. En. per Res.: -2.5208
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-33.6761	18.2901	-114.357	-129.743	92	5	0	5776	6	36	47
A-C	-8.3057	-1.0243	-101.37	-110.7	51	6	0	3782	1	7	4
B-D	-15.987	-1.0417	-109.01	-126.0388	50	6	0	3903	1	6	4

Interface residues

• A-B: ALA113A, ALA113B, ALA173A, ALA173B, ALA191A, ALA191B, ALA193A, ALA193B, ALA253B, ALA95A, ALA95B, ALA96A, ALA96B, ARG112A, ARG112B, ARG116A, ARG116B, ARG118A, ARG118B, ARG119A, ARG119B, ARG195A, ARG195B, ARG250A, ARG250B, ARG92A, ARG92B, ASN107A, ASN234A, ASN234B, ASP108A, ASP108B, ASP199A, ASP199B, ASP311A, ASP311B, GLN120A, GLN120B, GLU109A, GLU109B, GLU174A, GLU174B, GLU176A, GLU176B, GLU186A, GLU186B, GLU246A, GLU246B, GLU249A, GLU249B, GLY114A, GLY114B, GLY188A, GLY188B, GLY204A, GLY204B, HIS205A, HIS205B, LEU117A, LEU117B, LEU192A, LEU192B, LEU242A, LEU242B, LEU97A, LEU97B, LEU98A, LEU98B, LYS313A, LYS313B, MET239A, MET239B, PRO100A, PRO100B, PRO171A, PRO171B, PRO187A, PRO187B, PRO236A, PRO236B, PRO99A, PRO99B, SER115A, SER115B, SER203A, SER203B, THR190A, THR190B, THR196A, THR196B, TRP172A, TRP172B
• A-C: ALA274A, ALA290A, ARG1068C, ARG264A, ARG269A, ASP1072C, ASP245A, ASP304A, CYS267A, GLN1067C, GLN248A, GLN286A, GLN296A, GLN302A, GLU246A, GLU300A, GLY1075C, GLY276A, GLY301A, GLY305A, ILE275A, ILE284A, ILE288A, LEU1066C, LEU285A, LEU298A, LEU299A, LYS292A, LYS303A, PHE306A, PRO1073C, PRO289A, PRO41A, PRO42A, SER1070C, SER1071C, SER266A, SER279A, SER283A, SER40A, SER43A, THR1074C, THR243A, THR268A, THR287A, TYR244A, TYR277A, TYR307A, VAL247A, VAL297A, VAL39A
• B-D: ALA274B, ALA290B, ARG1068D, ARG264B, ARG269B, ASP1072D, ASP245B, ASP304B, CYS267B, GLN1067D, GLN248B, GLN286B, GLN296B, GLN302B, GLU246B, GLU300B, GLY1075D, GLY276B, GLY301B, GLY305B, ILE275B, ILE284B, ILE288B, LEU1066D, LEU285B, LEU298B, LEU299B, LYS292B, LYS303B, PHE306B, PRO1073D, PRO289B, PRO41B, PRO42B, SER1070D, SER1071D, SER266B, SER279B, SER283B, SER40B, SER43B, THR1074D, THR243B, THR268B, THR287B, TYR244B, TYR277B, TYR307B, VAL297B, VAL39B