3OOQ

crystal structure of amidohydrolase from thermotoga maritima msb8

• Total interactions analyzed: 45
• Total true interactions: 25
• Strongest Interaction:
  • Chains: A-F
  • Int. Res.: 129
  • Norm. En. per Res.: -3.8765
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-72.5268	-24.6111	-400.825	-497.9629	149	12	5	15309	6	52	38
A-C	-57.7554	-86.363	-299.026	-443.1444	132	14	8	12843	6	77	66
A-D	0.0	0.0	-0.4961	-0.4961	4	0	0	87	0	2	2
A-F	-68.3054	-116.9699	-314.799	-500.0743	129	15	7	13127	9	77	69
A-G	-5.5661	0.0	-11.0511	-16.6172	12	0	1	548	0	0	0
B-C	0.0	0.0	-12.3239	-12.3239	12	0	0	531	0	0	0
B-D	-51.3187	-96.3181	-306.001	-453.6378	130	11	7	13028	8	78	68
B-F	0.0	0.0	-0.3288	-0.3288	4	0	0	78	0	2	2
B-G	-59.355	-81.1036	-306.826	-447.2846	130	15	7	13185	8	78	68
C-D	-68.1893	-21.1789	-413.194	-502.5622	149	11	5	15623	5	52	40
C-H	0.0	0.0	-0.3868	-0.3868	4	0	0	88	0	2	2
C-J	-57.8853	-89.311	-317.473	-464.6693	134	12	7	13507	7	79	68
D-H	-62.8287	-85.0238	-315.139	-462.9916	129	14	7	13437	7	80	68
D-J	-2.7947	0.0	-13.0146	-15.8093	12	0	0	556	0	0	0
E-F	-9.5719	0.0	-13.2824	-22.8543	12	0	1	612	0	0	0
E-G	-61.1965	-98.2945	-316.67	-476.161	131	17	7	13196	9	78	67
E-H	-73.3464	-93.5478	-314.467	-481.3612	127	16	6	13034	8	78	67
E-I	-75.6611	-21.8569	-405.914	-503.432	149	13	5	15380	6	49	37
E-J	0.0	0.0	-0.5899	-0.5899	4	0	0	111	0	2	2
F-G	-65.506	-24.145	-396.883	-486.5339	147	11	6	15203	6	51	38
F-I	-66.7843	-117.2508	-300.843	-484.878	133	12	7	13257	11	77	66
G-I	0.0	0.0	-0.4803	-0.4803	4	0	0	116	0	2	2
H-I	-9.8662	0.0	-10.9815	-20.8477	12	1	1	589	0	0	0
H-J	-71.977	-25.2437	-410.817	-508.0377	149	14	5	15583	6	51	38
I-J	-59.0672	-103.9056	-318.254	-481.2268	128	12	7	13346	8	77	69

Interface residues

• A-B: ALA103A, ALA103B, ALA109A, ALA109B, ALA315A, ALA315B, ALA320A, ALA320B, ALA322A, ALA322B, ALA327A, ALA327B, ARG106A, ARG106B, ARG160A, ARG160B, ARG278A, ARG278B, ARG324A, ARG324B, ARG388A, ARG388B, ASP101A, ASP101B, ASP285A, ASP285B, ASP370A, ASP370B, GLN318A, GLN318B, GLU156A, GLU156B, GLU282A, GLU282B, GLU289A, GLU289B, GLU313A, GLU313B, GLU329A, GLU329B, GLU330A, GLU330B, GLU70A, GLU70B, GLU71A, GLU71B, GLY110A, GLY110B, GLY111A, GLY111B, GLY326A, GLY326B, GLY366A, GLY366B, GLY67A, GLY67B, GLY72A, GLY72B, GLY74A, GLY74B, HIS307A, HIS307B, HIS367A, HIS367B, HIS65A, HIS65B, ILE104B, ILE310A, ILE310B, ILE66A, ILE66B, LEU274A, LEU274B, LEU275A, LEU275B, LEU281A, LEU281B, LEU283A, LEU283B, LEU286A, LEU286B, LEU312A, LEU312B, LEU332A, LEU332B, LEU68A, LEU68B, LYS280A, LYS280B, LYS284A, LYS284B, LYS328A, LYS328B, LYS372A, LYS372B, PHE277A, PHE277B, PHE314A, PHE314B, PHE369A, PHE369B, PHE59A, PHE59B, PHE69A, PHE69B, PRO102A, PRO102B, PRO308A, PRO308B, PRO311A, PRO311B, PRO368A, PRO368B, SER365A, SER365B, SER373A, SER373B, SER78A, SER78B, THR276A, THR276B, THR279A, THR279B, THR287A, THR287B, THR316A, THR316B, THR321A, THR321B, TRP364A, TRP364B, TYR325A, TYR325B, TYR75A, TYR75B, TYR76A, TYR76B, TYR77A, TYR77B, VAL309A, VAL309B, VAL317A, VAL317B, VAL374A, VAL374B, VAL375A, VAL375B, VAL73A, VAL73B
• A-C: ALA176A, ALA196A, ALA230A, ALA83C, ALA93C, ARG160A, ARG165A, ARG165C, ARG172A, ARG180A, ARG229A, ARG238A, ASN123C, ASN157A, ASN188A, ASN81C, ASN98C, ASP101C, ASP146C, ASP181A, ASP207C, ASP231A, ASP232A, ASP285A, ASP79C, ASP85C, ASP95C, GLN100C, GLN128C, GLN167A, GLN167C, GLU140C, GLU141C, GLU156A, GLU164A, GLU164C, GLU194A, GLU199A, GLU202C, GLU205C, GLU211C, GLU241A, GLU242A, GLU254A, GLU282A, GLU70C, GLU71C, GLU82C, GLY120C, GLY126C, GLY155A, GLY163A, GLY174A, GLY177A, GLY200C, GLY67C, GLY72C, GLY74C, GLY80C, GLY96C, HIS228A, HIS90C, ILE137C, ILE138C, ILE143C, ILE179A, ILE233A, ILE237A, ILE239A, ILE258A, LEU195A, LEU208C, LEU234A, LEU281A, LEU68C, LEU94C, LYS159A, LYS166A, LYS185A, LYS187A, LYS191A, LYS192A, LYS193A, LYS198A, LYS201C, LYS209C, LYS257A, LYS260A, LYS265A, LYS280A, LYS284A, LYS92C, PHE154A, PHE183A, PHE203C, PHE243A, PHE69C, PHE97C, PRO102C, PRO119C, PRO169A, PRO99C, SER136C, SER170A, SER259A, SER78C, THR168A, THR171A, THR175A, THR184A, THR204C, THR206C, THR235A, THR279A, THR84C, THR88C, TYR162A, TYR162C, TYR182A, TYR189A, TYR189C, TYR256A, TYR75C, TYR76C, TYR77C, VAL139C, VAL161A, VAL178A, VAL212C, VAL261A, VAL73C, VAL91C
• A-D: LEU281A, LEU281D, LYS284A, LYS284D
• A-F: ALA176F, ALA196F, ALA230F, ALA83A, ALA93A, ARG160F, ARG165A, ARG165F, ARG172F, ARG180F, ARG229F, ARG238F, ASN123A, ASN188F, ASN81A, ASN98A, ASP101A, ASP146A, ASP181F, ASP207A, ASP231F, ASP232F, ASP285F, ASP79A, ASP85A, ASP95A, GLN100A, GLN128A, GLN167A, GLN167F, GLU140A, GLU141A, GLU156F, GLU164A, GLU164F, GLU194F, GLU199F, GLU202A, GLU205A, GLU211A, GLU241F, GLU242F, GLU254F, GLU282F, GLU70A, GLU71A, GLU82A, GLY120A, GLY155F, GLY163F, GLY174F, GLY177F, GLY200A, GLY67A, GLY72A, GLY74A, GLY80A, GLY96A, HIS228F, HIS90A, ILE137A, ILE138A, ILE143A, ILE179F, ILE233F, ILE237F, ILE239F, ILE258F, LEU195F, LEU208A, LEU234F, LEU262F, LEU281F, LEU68A, LEU94A, LYS159F, LYS166F, LYS185F, LYS187F, LYS191F, LYS192F, LYS193F, LYS198F, LYS201A, LYS209A, LYS257F, LYS260F, LYS265F, LYS280F, LYS284F, LYS92A, PHE154F, PHE183F, PHE203A, PHE243F, PHE97A, PRO102A, PRO119A, PRO169F, PRO99A, SER136A, SER170F, SER259F, SER78A, THR168F, THR171F, THR175F, THR184F, THR204A, THR206A, THR235F, THR279F, THR84A, THR88A, TYR162A, TYR162F, TYR182F, TYR189A, TYR189F, TYR256F, TYR75A, TYR76A, TYR77A, VAL139A, VAL161F, VAL178F, VAL261F, VAL73A, VAL91A
• A-G: GLY72A, GLY72G, GLY74A, GLY74G, TYR75A, TYR75G, TYR76A, TYR76G, TYR77A, TYR77G, VAL73A, VAL73G
• B-C: GLY72B, GLY72C, GLY74B, GLY74C, TYR75B, TYR75C, TYR76B, TYR76C, TYR77B, TYR77C, VAL73B, VAL73C
• B-D: ALA176D, ALA196D, ALA230D, ALA83B, ALA93B, ARG160D, ARG165B, ARG165D, ARG172D, ARG180D, ARG229D, ARG238D, ASN123B, ASN157D, ASN188D, ASN81B, ASN98B, ASP101B, ASP146B, ASP181D, ASP207B, ASP231D, ASP232D, ASP285D, ASP79B, ASP85B, ASP95B, GLN100B, GLN128B, GLN167B, GLN167D, GLU140B, GLU141B, GLU156D, GLU164B, GLU164D, GLU194D, GLU199D, GLU202B, GLU205B, GLU205D, GLU211B, GLU241D, GLU242D, GLU254D, GLU282D, GLU70B, GLU71B, GLU82B, GLY120B, GLY155D, GLY163D, GLY174D, GLY177D, GLY200B, GLY67B, GLY72B, GLY74B, GLY80B, GLY96B, HIS228D, HIS90B, ILE137B, ILE138B, ILE143B, ILE179D, ILE233D, ILE237D, ILE239D, ILE258D, LEU195D, LEU208B, LEU234D, LEU262D, LEU281D, LEU68B, LEU94B, LYS159D, LYS166D, LYS185D, LYS187D, LYS191D, LYS192D, LYS193D, LYS198D, LYS201B, LYS209B, LYS257D, LYS260D, LYS265D, LYS280D, LYS284D, LYS92B, PHE154D, PHE183D, PHE203B, PHE243D, PHE97B, PRO102B, PRO119B, PRO169D, PRO99B, SER136B, SER170D, SER259D, SER78B, THR168D, THR171D, THR175D, THR184D, THR204B, THR206B, THR235D, THR279D, THR84B, THR88B, TYR162D, TYR182D, TYR189B, TYR189D, TYR256D, TYR75B, TYR76B, TYR77B, VAL139B, VAL161D, VAL178D, VAL261D, VAL73B, VAL91B
• B-F: LEU281B, LEU281F, LYS284B, LYS284F
• B-G: ALA176B, ALA196B, ALA230B, ALA83G, ALA93G, ARG160B, ARG165B, ARG165G, ARG172B, ARG180B, ARG229B, ARG238B, ASN123G, ASN157B, ASN188B, ASN81G, ASN98G, ASP101G, ASP146G, ASP181B, ASP207G, ASP231B, ASP232B, ASP285B, ASP79G, ASP85G, ASP95G, GLN100G, GLN128G, GLN167B, GLN167G, GLU140G, GLU141G, GLU156B, GLU164B, GLU164G, GLU194B, GLU199B, GLU202G, GLU205G, GLU211G, GLU241B, GLU242B, GLU254B, GLU282B, GLU70G, GLU71G, GLU82G, GLY120G, GLY155B, GLY163B, GLY174B, GLY177B, GLY200G, GLY67G, GLY72G, GLY74G, GLY80G, GLY96G, HIS228B, HIS90G, ILE137G, ILE138G, ILE143G, ILE179B, ILE233B, ILE237B, ILE239B, ILE258B, LEU195B, LEU208G, LEU234B, LEU262B, LEU281B, LEU68G, LEU94G, LYS159B, LYS166B, LYS185B, LYS187B, LYS191B, LYS192B, LYS193B, LYS198B, LYS201G, LYS209G, LYS257B, LYS260B, LYS265B, LYS280B, LYS284B, LYS92G, PHE154B, PHE183B, PHE203G, PHE243B, PHE97G, PRO102G, PRO119G, PRO169B, PRO99G, SER136G, SER170B, SER259B, SER78G, THR168B, THR171B, THR175B, THR184B, THR204G, THR206G, THR235B, THR279B, THR84G, THR88G, TYR162B, TYR162G, TYR182B, TYR189B, TYR189G, TYR256B, TYR75G, TYR76G, TYR77G, VAL139G, VAL161B, VAL178B, VAL261B, VAL73G, VAL91G
• C-D: ALA103C, ALA103D, ALA109C, ALA109D, ALA315C, ALA315D, ALA320C, ALA320D, ALA322C, ALA322D, ALA327C, ALA327D, ARG106C, ARG106D, ARG160C, ARG160D, ARG278C, ARG278D, ARG324C, ARG324D, ARG388C, ARG388D, ASP101C, ASP101D, ASP285C, ASP285D, ASP370C, ASP370D, GLN318C, GLN318D, GLU156C, GLU156D, GLU282C, GLU282D, GLU289C, GLU289D, GLU313C, GLU313D, GLU329C, GLU329D, GLU330C, GLU389C, GLU70C, GLU70D, GLU71C, GLU71D, GLY110C, GLY110D, GLY111C, GLY111D, GLY326C, GLY326D, GLY366C, GLY366D, GLY67C, GLY67D, GLY72C, GLY72D, GLY74C, GLY74D, HIS307C, HIS307D, HIS367C, HIS367D, HIS65C, HIS65D, ILE104C, ILE310C, ILE310D, ILE66C, ILE66D, LEU274C, LEU274D, LEU275C, LEU275D, LEU281C, LEU281D, LEU283C, LEU283D, LEU286C, LEU286D, LEU312C, LEU312D, LEU332C, LEU332D, LEU68C, LEU68D, LYS280C, LYS280D, LYS284C, LYS284D, LYS328C, LYS328D, LYS372C, LYS372D, PHE277C, PHE277D, PHE314C, PHE314D, PHE369C, PHE369D, PHE59C, PHE59D, PHE69C, PHE69D, PRO102C, PRO102D, PRO308C, PRO308D, PRO311C, PRO311D, PRO368C, PRO368D, SER365C, SER365D, SER373C, SER373D, SER78C, SER78D, THR276C, THR276D, THR279C, THR279D, THR287C, THR287D, THR316C, THR316D, THR321C, THR321D, TRP364C, TRP364D, TYR325C, TYR325D, TYR75C, TYR75D, TYR76C, TYR76D, TYR77C, TYR77D, VAL309C, VAL309D, VAL317C, VAL317D, VAL374C, VAL374D, VAL375C, VAL375D, VAL73C, VAL73D
• C-H: LEU281C, LEU281H, LYS284C, LYS284H
• C-J: ALA176C, ALA196C, ALA196J, ALA230C, ALA83J, ALA93J, ARG160C, ARG165C, ARG165J, ARG172C, ARG180C, ARG229C, ARG238C, ASN123J, ASN157C, ASN188C, ASN81J, ASN98J, ASP101J, ASP146J, ASP181C, ASP207J, ASP231C, ASP232C, ASP285C, ASP79J, ASP85J, ASP95J, GLN100J, GLN128J, GLN167C, GLN167J, GLU140J, GLU141J, GLU156C, GLU164C, GLU164J, GLU194C, GLU199C, GLU199J, GLU202J, GLU205J, GLU211J, GLU241C, GLU242C, GLU254C, GLU282C, GLU70J, GLU71J, GLU82J, GLY120J, GLY155C, GLY163C, GLY174C, GLY177C, GLY200J, GLY67J, GLY72J, GLY74J, GLY80J, GLY96J, HIS228C, HIS90J, ILE137J, ILE138J, ILE143J, ILE179C, ILE233C, ILE237C, ILE239C, ILE258C, LEU195C, LEU208J, LEU234C, LEU262C, LEU281C, LEU68J, LEU94J, LYS159C, LYS166C, LYS185C, LYS187C, LYS191C, LYS192C, LYS193C, LYS198C, LYS201C, LYS201J, LYS209J, LYS257C, LYS260C, LYS265C, LYS280C, LYS284C, LYS92J, PHE154C, PHE183C, PHE203C, PHE203J, PHE243C, PHE97J, PRO102J, PRO119J, PRO169C, PRO99J, SER136J, SER170C, SER259C, SER78J, THR168C, THR171C, THR175C, THR184C, THR204J, THR206J, THR235C, THR279C, THR84J, THR88J, TYR162C, TYR162J, TYR182C, TYR189C, TYR189J, TYR256C, TYR75J, TYR76J, TYR77J, VAL139J, VAL161C, VAL178C, VAL261C, VAL73J, VAL91J
• D-H: ALA176H, ALA196H, ALA230H, ALA83D, ALA93D, ARG160H, ARG165D, ARG165H, ARG172H, ARG180H, ARG229H, ARG238H, ASN123D, ASN188H, ASN81D, ASN98D, ASP101D, ASP146D, ASP181H, ASP207D, ASP231H, ASP232H, ASP285H, ASP79D, ASP85D, ASP95D, GLN100D, GLN128D, GLN167D, GLN167H, GLU140D, GLU141D, GLU156H, GLU164D, GLU164H, GLU194H, GLU199H, GLU202D, GLU205D, GLU211D, GLU241H, GLU242H, GLU254H, GLU282H, GLU70D, GLU71D, GLU82D, GLY120D, GLY155H, GLY163H, GLY174H, GLY177H, GLY200D, GLY67D, GLY72D, GLY74D, GLY80D, GLY96D, HIS228H, HIS90D, ILE137D, ILE138D, ILE143D, ILE179H, ILE233H, ILE237H, ILE239H, ILE258H, LEU195H, LEU208D, LEU234H, LEU262H, LEU281H, LEU68D, LEU94D, LYS159H, LYS166H, LYS185H, LYS187H, LYS191H, LYS192H, LYS193H, LYS198H, LYS201D, LYS201H, LYS209D, LYS257H, LYS260H, LYS265H, LYS280H, LYS284H, LYS92D, PHE154H, PHE183H, PHE203D, PHE243H, PHE97D, PRO102D, PRO119D, PRO169H, PRO99D, SER136D, SER170H, SER259H, SER78D, THR168H, THR171H, THR175H, THR184H, THR204D, THR206D, THR235H, THR279H, THR84D, THR88D, TYR162H, TYR182H, TYR189D, TYR189H, TYR256H, TYR75D, TYR76D, TYR77D, VAL139D, VAL161H, VAL178H, VAL261H, VAL73D, VAL91D
• D-J: GLY72D, GLY72J, GLY74D, GLY74J, TYR75D, TYR75J, TYR76D, TYR76J, TYR77D, TYR77J, VAL73D, VAL73J
• E-F: GLY72E, GLY72F, GLY74E, GLY74F, TYR75E, TYR75F, TYR76E, TYR76F, TYR77E, TYR77F, VAL73E, VAL73F
• E-G: ALA176G, ALA196G, ALA230G, ALA83E, ALA93E, ARG160G, ARG165E, ARG165G, ARG172G, ARG180G, ARG229G, ARG238G, ASN123E, ASN157G, ASN188G, ASN81E, ASN98E, ASP101E, ASP146E, ASP181G, ASP207E, ASP231G, ASP232G, ASP285G, ASP79E, ASP85E, ASP95E, CYS142E, GLN100E, GLN128E, GLN167E, GLN167G, GLU140E, GLU141E, GLU156G, GLU164E, GLU164G, GLU194G, GLU199G, GLU202E, GLU205E, GLU211E, GLU241G, GLU242G, GLU254G, GLU264G, GLU282G, GLU70E, GLU71E, GLU82E, GLY120E, GLY155G, GLY163G, GLY174G, GLY177G, GLY67E, GLY72E, GLY74E, GLY80E, GLY96E, HIS228G, HIS90E, ILE137E, ILE138E, ILE143E, ILE179G, ILE233G, ILE237G, ILE239G, ILE258G, LEU195G, LEU208E, LEU234G, LEU262G, LEU281G, LEU68E, LEU94E, LYS159G, LYS166G, LYS185G, LYS187G, LYS191G, LYS192G, LYS193G, LYS198G, LYS201E, LYS209E, LYS257G, LYS260G, LYS265G, LYS280G, LYS284G, LYS92E, PHE154G, PHE183G, PHE203E, PHE243G, PHE97E, PRO102E, PRO119E, PRO169G, PRO99E, SER136E, SER170G, SER259G, SER78E, THR168G, THR171G, THR175G, THR184G, THR204E, THR206E, THR235G, THR279G, THR84E, THR88E, TYR162E, TYR162G, TYR182G, TYR189E, TYR189G, TYR256G, TYR75E, TYR76E, TYR77E, VAL139E, VAL161G, VAL178G, VAL261G, VAL73E, VAL91E
• E-H: ALA176E, ALA196E, ALA230E, ALA83H, ALA93H, ARG160E, ARG165E, ARG165H, ARG172E, ARG180E, ARG229E, ARG238E, ASN123H, ASN188E, ASN81H, ASN98H, ASP101H, ASP146H, ASP181E, ASP207H, ASP231E, ASP232E, ASP285E, ASP79H, ASP85H, ASP95H, GLN100H, GLN128H, GLN167E, GLN167H, GLU140H, GLU141H, GLU156E, GLU164E, GLU194E, GLU199E, GLU202H, GLU205E, GLU205H, GLU211H, GLU241E, GLU242E, GLU254E, GLU282E, GLU70H, GLU71H, GLU82H, GLY120H, GLY155E, GLY163E, GLY174E, GLY177E, GLY67H, GLY72H, GLY74H, GLY80H, GLY96H, HIS228E, HIS90H, ILE137H, ILE138H, ILE143H, ILE179E, ILE233E, ILE237E, ILE239E, ILE258E, LEU195E, LEU208H, LEU234E, LEU262E, LEU281E, LEU68H, LEU94H, LYS159E, LYS166E, LYS185E, LYS187E, LYS191E, LYS192E, LYS193E, LYS198E, LYS201H, LYS209H, LYS257E, LYS260E, LYS265E, LYS280E, LYS284E, LYS92H, PHE154E, PHE183E, PHE203H, PHE243E, PHE97H, PRO102H, PRO119H, PRO169E, PRO99H, SER136H, SER170E, SER259E, SER78H, THR168E, THR171E, THR175E, THR184E, THR204H, THR206H, THR235E, THR279E, THR84H, THR88H, TYR162E, TYR182E, TYR189E, TYR189H, TYR256E, TYR75H, TYR76H, TYR77H, VAL139H, VAL161E, VAL178E, VAL261E, VAL73H, VAL91H
• E-I: ALA103E, ALA103I, ALA109E, ALA109I, ALA315E, ALA315I, ALA320E, ALA320I, ALA322E, ALA322I, ALA327E, ALA327I, ARG106E, ARG106I, ARG160E, ARG160I, ARG278E, ARG278I, ARG324E, ARG324I, ARG388E, ARG388I, ASP101E, ASP101I, ASP285E, ASP285I, ASP370E, ASP370I, GLN318E, GLN318I, GLU156E, GLU156I, GLU282E, GLU282I, GLU289E, GLU289I, GLU313E, GLU313I, GLU329E, GLU329I, GLU330E, GLU70E, GLU70I, GLU71E, GLU71I, GLY110E, GLY110I, GLY111E, GLY111I, GLY326E, GLY326I, GLY366E, GLY366I, GLY67E, GLY67I, GLY72E, GLY72I, GLY74E, GLY74I, HIS307E, HIS307I, HIS367E, HIS367I, HIS65E, HIS65I, ILE104E, ILE104I, ILE310E, ILE310I, ILE66E, ILE66I, LEU274E, LEU274I, LEU275E, LEU275I, LEU281E, LEU281I, LEU283E, LEU283I, LEU286E, LEU286I, LEU312E, LEU312I, LEU332E, LEU332I, LEU68E, LEU68I, LYS280E, LYS280I, LYS284E, LYS284I, LYS328E, LYS328I, LYS372E, LYS372I, PHE277E, PHE277I, PHE314E, PHE314I, PHE369E, PHE369I, PHE59E, PHE59I, PHE69E, PHE69I, PRO102E, PRO102I, PRO308E, PRO308I, PRO311E, PRO311I, PRO368E, PRO368I, SER365E, SER365I, SER373E, SER373I, SER78E, SER78I, THR276E, THR276I, THR279E, THR279I, THR287E, THR287I, THR316E, THR316I, THR321E, THR321I, TRP364E, TRP364I, TYR325E, TYR325I, TYR75E, TYR75I, TYR76E, TYR76I, TYR77E, TYR77I, VAL309E, VAL309I, VAL317E, VAL317I, VAL374E, VAL374I, VAL375E, VAL375I, VAL73E, VAL73I
• E-J: LEU281E, LEU281J, LYS284E, LYS284J
• F-G: ALA103F, ALA103G, ALA109F, ALA109G, ALA315F, ALA315G, ALA320F, ALA320G, ALA322F, ALA322G, ALA327F, ALA327G, ARG106F, ARG106G, ARG160F, ARG160G, ARG278F, ARG278G, ARG324F, ARG324G, ARG388F, ARG388G, ASP101F, ASP101G, ASP285F, ASP285G, ASP370F, ASP370G, GLN318F, GLN318G, GLU156F, GLU156G, GLU282F, GLU282G, GLU289F, GLU289G, GLU313F, GLU313G, GLU329F, GLU329G, GLU70F, GLU70G, GLU71F, GLU71G, GLY110F, GLY110G, GLY111F, GLY111G, GLY326F, GLY326G, GLY366F, GLY366G, GLY67F, GLY67G, GLY72F, GLY72G, GLY74F, GLY74G, HIS307F, HIS307G, HIS367F, HIS367G, HIS65F, HIS65G, ILE104G, ILE310F, ILE310G, ILE66F, ILE66G, LEU274F, LEU274G, LEU275F, LEU275G, LEU281F, LEU281G, LEU283F, LEU283G, LEU286F, LEU286G, LEU312F, LEU312G, LEU332F, LEU332G, LEU68F, LEU68G, LYS280F, LYS280G, LYS284F, LYS284G, LYS328F, LYS328G, LYS372F, LYS372G, PHE277F, PHE277G, PHE314F, PHE314G, PHE369F, PHE369G, PHE59F, PHE59G, PHE69F, PHE69G, PRO102F, PRO102G, PRO308F, PRO308G, PRO311F, PRO311G, PRO368F, PRO368G, SER365F, SER365G, SER373F, SER373G, SER78F, SER78G, THR276F, THR276G, THR279F, THR279G, THR287F, THR287G, THR316F, THR316G, THR321F, THR321G, TRP364F, TRP364G, TYR325F, TYR325G, TYR75F, TYR75G, TYR76F, TYR76G, TYR77F, TYR77G, VAL309F, VAL309G, VAL317F, VAL317G, VAL374F, VAL374G, VAL375F, VAL375G, VAL73F, VAL73G
• F-I: ALA176I, ALA196I, ALA230I, ALA83F, ALA93F, ARG160I, ARG165F, ARG165I, ARG172I, ARG180I, ARG229I, ARG238I, ASN123F, ASN157I, ASN188I, ASN81F, ASN98F, ASP101F, ASP146F, ASP181I, ASP207F, ASP231I, ASP232I, ASP285I, ASP79F, ASP85F, ASP95F, CYS142F, GLN100F, GLN128F, GLN167F, GLN167I, GLU140F, GLU141F, GLU156I, GLU164I, GLU194I, GLU199I, GLU202F, GLU205F, GLU211F, GLU241I, GLU242I, GLU254I, GLU264I, GLU282I, GLU70F, GLU71F, GLU82F, GLY120F, GLY155I, GLY163I, GLY174I, GLY177I, GLY200F, GLY67F, GLY72F, GLY74F, GLY80F, GLY96F, HIS228I, HIS90F, ILE137F, ILE138F, ILE143F, ILE179I, ILE233I, ILE237I, ILE239I, ILE258I, LEU195I, LEU208F, LEU234I, LEU262I, LEU281I, LEU68F, LEU94F, LYS159I, LYS166I, LYS185I, LYS187I, LYS191I, LYS192I, LYS193I, LYS198I, LYS201F, LYS201I, LYS209F, LYS257I, LYS260I, LYS265I, LYS280I, LYS284I, LYS92F, PHE154I, PHE183I, PHE203F, PHE243I, PHE97F, PRO102F, PRO119F, PRO169I, PRO99F, SER136F, SER170I, SER259I, SER78F, THR168I, THR171I, THR175I, THR184I, THR204F, THR206F, THR235I, THR279I, THR84F, THR88F, TYR162F, TYR162I, TYR182I, TYR189F, TYR189I, TYR256I, TYR75F, TYR76F, TYR77F, VAL139F, VAL161I, VAL178I, VAL261I, VAL73F, VAL87F, VAL91F
• G-I: LEU281G, LEU281I, LYS284G, LYS284I
• H-I: GLY72H, GLY72I, GLY74H, GLY74I, TYR75H, TYR75I, TYR76H, TYR76I, TYR77H, TYR77I, VAL73H, VAL73I
• H-J: ALA103H, ALA103J, ALA109H, ALA109J, ALA315H, ALA315J, ALA320H, ALA320J, ALA322H, ALA322J, ALA327H, ALA327J, ARG106H, ARG106J, ARG160H, ARG160J, ARG278H, ARG278J, ARG324H, ARG324J, ARG388H, ARG388J, ASN157J, ASP101H, ASP101J, ASP285H, ASP285J, ASP370H, ASP370J, GLN318H, GLN318J, GLU156H, GLU156J, GLU282H, GLU282J, GLU289H, GLU289J, GLU313H, GLU313J, GLU329H, GLU329J, GLU70H, GLU70J, GLU71H, GLU71J, GLY110H, GLY110J, GLY111H, GLY111J, GLY326H, GLY326J, GLY366H, GLY366J, GLY67H, GLY67J, GLY72H, GLY72J, GLY74H, GLY74J, HIS307H, HIS307J, HIS367H, HIS367J, HIS65H, HIS65J, ILE104H, ILE104J, ILE310H, ILE310J, ILE66H, ILE66J, LEU274H, LEU274J, LEU275H, LEU275J, LEU281H, LEU281J, LEU283H, LEU283J, LEU286H, LEU286J, LEU312H, LEU312J, LEU332H, LEU332J, LEU68H, LEU68J, LYS280H, LYS280J, LYS284H, LYS284J, LYS328H, LYS328J, LYS372H, LYS372J, PHE277H, PHE277J, PHE314H, PHE314J, PHE369H, PHE369J, PHE59H, PHE59J, PHE69H, PHE69J, PRO102H, PRO102J, PRO308H, PRO308J, PRO311H, PRO311J, PRO368H, PRO368J, SER365H, SER365J, SER373H, SER373J, SER78H, SER78J, THR276H, THR276J, THR279H, THR279J, THR287H, THR287J, THR316H, THR316J, THR321H, THR321J, TRP364H, TRP364J, TYR325H, TYR325J, TYR75H, TYR75J, TYR76H, TYR76J, TYR77H, TYR77J, VAL309H, VAL309J, VAL317H, VAL317J, VAL374H, VAL374J, VAL375H, VAL375J, VAL73H, VAL73J
• I-J: ALA176J, ALA196J, ALA230J, ALA83I, ALA93I, ARG160J, ARG165I, ARG165J, ARG172J, ARG180J, ARG229J, ARG238J, ASN123I, ASN188J, ASN81I, ASN98I, ASP101I, ASP146I, ASP181J, ASP207I, ASP231J, ASP232J, ASP285J, ASP79I, ASP85I, ASP95I, GLN100I, GLN128I, GLN167I, GLN167J, GLU140I, GLU141I, GLU156J, GLU164I, GLU164J, GLU194J, GLU199J, GLU202I, GLU205I, GLU211I, GLU241J, GLU242J, GLU254J, GLU282J, GLU70I, GLU71I, GLU82I, GLY120I, GLY155J, GLY163J, GLY174J, GLY177J, GLY200I, GLY67I, GLY72I, GLY74I, GLY80I, GLY96I, HIS228J, HIS90I, ILE137I, ILE138I, ILE143I, ILE179J, ILE237J, ILE239J, ILE258J, LEU195J, LEU208I, LEU234J, LEU262J, LEU281J, LEU68I, LEU94I, LYS159J, LYS166J, LYS185J, LYS187J, LYS191J, LYS192J, LYS193J, LYS198J, LYS201I, LYS209I, LYS257J, LYS260J, LYS265J, LYS280J, LYS284J, LYS92I, PHE154J, PHE183J, PHE203I, PHE243J, PHE97I, PRO102I, PRO119I, PRO169J, PRO99I, SER136I, SER170J, SER259J, SER78I, THR168J, THR171J, THR175J, THR184J, THR204I, THR206I, THR235J, THR279J, THR84I, THR88I, TYR162J, TYR182J, TYR189I, TYR189J, TYR256J, TYR75I, TYR76I, TYR77I, VAL139I, VAL161J, VAL178J, VAL261J, VAL73I, VAL87I, VAL91I