3OOJ

c1a mutant of e. coli glms in complex with glucose-6p and glutamate

• Total interactions analyzed: 28
• Total true interactions: 15
• Strongest Interaction:
  • Chains: B-H
  • Int. Res.: 147
  • Norm. En. per Res.: -3.4001
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-144.79	87.074	-714.343	-772.059	244	35	11	26990	23	134	121
A-C	0.0	-6.5811	-26.0501	-32.6312	24	0	2	1104	0	19	17
A-D	-97.3859	-39.0943	-284.298	-420.7782	144	17	1	10973	12	60	57
A-H	0.0	-4.7834	-26.1811	-30.9645	26	1	2	1081	0	16	15
B-D	0.0	-6.5016	-21.7083	-28.2099	22	0	1	915	0	14	14
B-F	-8.4489	25.0792	-135.878	-119.2477	103	3	4	6855	0	36	40
B-G	0.0	-6.1802	-20.562	-26.7422	21	0	1	914	0	14	14
B-H	-116.765	-54.3771	-328.676	-499.818	147	14	2	12729	19	61	57
C-D	-142.2782	72.2516	-714.047	-784.0736	242	31	11	26969	24	134	119
C-G	-79.2721	-51.2704	-264.869	-395.4115	134	13	0	9961	12	61	61
C-H	-2.2803	-8.3187	-28.1615	-38.7605	29	0	2	1174	0	17	16
D-G	0.0	-6.0523	-19.5265	-25.5788	21	0	1	892	0	15	14
E-F	-151.1573	71.3749	-717.293	-797.0754	249	33	12	26996	25	132	122
F-H	0.0	-3.0426	-2.6117	-5.6543	18	0	0	327	0	5	5
G-H	-155.9928	30.5976	-694.695	-820.0902	243	32	12	26392	20	136	121

Interface residues

• A-B: ALA299A, ALA299B, ALA318A, ALA318B, ALA327A, ALA327B, ALA336A, ALA336B, ALA353A, ALA353B, ALA467A, ALA467B, ALA483A, ALA483B, ALA494A, ALA494B, ALA496A, ALA496B, ALA498A, ALA498B, ALA499A, ALA499B, ALA508A, ALA508B, ALA512A, ALA512B, ALA538A, ALA538B, ALA602A, ALA602B, ARG311A, ARG311B, ARG331A, ARG331B, ARG333A, ARG333B, ARG338A, ARG338B, ARG339A, ARG339B, ARG421A, ARG421B, ARG472A, ARG472B, ARG537A, ARG537B, ARG539A, ARG539B, ARG599A, ARG599B, ASN305A, ASN305B, ASN340A, ASN340B, ASN522A, ASN522B, ASN532A, ASN532B, ASN600A, ASN600B, ASP323A, ASP323B, ASP354A, ASP354B, ASP426A, ASP474A, ASP474B, ASP511A, ASP511B, ASP513A, ASP513B, CYS300A, CYS300B, CYS322A, CYS322B, GLN296A, GLN296B, GLN475A, GLN475B, GLU293A, GLU293B, GLU315A, GLU315B, GLU325A, GLU325B, GLU329A, GLU329B, GLU488A, GLU488B, GLU495A, GLU495B, GLU501A, GLU501B, GLU524A, GLU524B, GLU527A, GLU534A, GLU534B, GLU535A, GLU535B, GLU608A, GLU608B, GLY301A, GLY301B, GLY319A, GLY319B, GLY471A, GLY471B, GLY473A, GLY473B, GLY500A, GLY500B, GLY505A, GLY505B, HIS294A, HIS294B, HIS465A, HIS465B, HIS466A, HIS466B, HIS493A, HIS493B, HIS504A, HIS504B, ILE295A, ILE295B, ILE320A, ILE320B, ILE326A, ILE326B, ILE429A, ILE429B, ILE489A, ILE489B, ILE492A, ILE492B, ILE510A, ILE510B, ILE533A, ILE533B, LEU298A, LEU298B, LEU317A, LEU317B, LEU422A, LEU422B, LEU425B, LEU468A, LEU468B, LEU480A, LEU480B, LEU484A, LEU484B, LEU486A, LEU486B, LEU502A, LEU502B, LEU507A, LEU507B, LEU509A, LEU509B, LEU525A, LEU525B, LEU601A, LEU601B, LYS334A, LYS334B, LYS423A, LYS464A, LYS464B, LYS487A, LYS487B, LYS503A, LYS503B, LYS528A, LYS528B, LYS603A, LYS603B, MET308A, MET308B, MET514A, MET514B, PHE314A, PHE314B, PHE330A, PHE330B, PHE469A, PHE469B, PRO321A, PRO321B, PRO477A, PRO477B, PRO506A, PRO506B, PRO598A, PRO598B, SER303A, SER303B, SER316A, SER316B, SER328A, SER328B, SER335A, SER335B, SER349A, SER490A, SER490B, SER531A, SER604A, SER604B, THR302A, THR302B, THR352A, THR352B, THR355A, THR355B, THR606A, THR606B, TRP313A, TRP313B, TYR304A, TYR304B, TYR312A, TYR312B, TYR332A, TYR332B, TYR476A, TYR476B, TYR491A, TYR491B, TYR497A, TYR497B, VAL324A, VAL324B, VAL337A, VAL337B, VAL399A, VAL399B, VAL536A, VAL536B, VAL605A, VAL605B, VAL607A, VAL607B
• A-C: ALA456A, ALA458A, ALA508C, ALA538C, ARG249A, ARG537C, ARG539C, ASP460A, ASP463A, ASP511C, GLU455A, GLU459A, GLU535C, GLY540C, GLY592A, HIS586A, ILE510C, ILE590A, LEU589A, LYS503C, LYS591A, SER462A, VAL536C, VAL587A
• A-D: ALA13A, ALA13D, ALA195A, ALA242A, ALA242D, ALA588A, ALA588D, ALA602A, ALA602D, ALA8A, ALA8D, ARG10A, ARG10D, ARG201A, ARG201D, ARG202A, ARG202D, ARG216A, ARG216D, ARG217A, ARG217D, ARG21A, ARG21D, ARG22A, ARG22D, ARG249A, ARG249D, ARG599A, ARG599D, ASN187A, ASN187D, ASN237A, ASN600A, ASN600D, ASP11A, ASP11D, ASP233A, ASP241A, ASP244A, ASP244D, ASP594A, ASP594D, ASP596A, ASP596D, GLN232A, GLN239A, GLN597A, GLN597D, GLN9A, GLN9D, GLU14A, GLU14D, GLU186A, GLU186D, GLU18A, GLU18D, GLU235A, GLU235D, GLU608D, GLY183A, GLY183D, GLY185A, GLY185D, GLY19A, GLY19D, GLY243A, GLY243D, GLY592A, GLY592D, GLY65A, GLY65D, GLY66A, GLY66D, HIS250A, HIS250D, HIS64A, HIS64D, ILE15A, ILE15D, ILE234A, ILE397A, ILE397D, ILE489A, ILE489D, ILE590A, ILE590D, LEU16A, LEU16D, LEU17A, LEU17D, LEU182A, LEU182D, LEU196A, LEU197A, LEU197D, LEU238A, LEU589A, LEU589D, LEU601A, LEU601D, LEU63A, LYS245A, LYS245D, LYS591A, LYS591D, LYS603A, LYS603D, MET184A, MET184D, PHE188A, PHE188D, PRO198A, PRO198D, PRO598A, PRO598D, PRO62A, SER236A, SER462A, SER462D, SER490A, SER490D, THR200A, THR200D, THR593A, THR593D, THR606D, TYR240A, TYR248A, TYR248D, TYR251A, TYR251D, TYR491A, TYR491D, TYR585A, TYR585D, VAL12A, VAL12D, VAL199A, VAL199D, VAL399A, VAL399D, VAL595A, VAL595D, VAL607D
• A-H: ALA456H, ALA458H, ALA508A, ALA512A, ALA538A, ARG249H, ARG537A, ARG539A, ASP460H, ASP463H, ASP511A, GLN232H, GLU455H, GLU459H, GLU535A, GLY540A, GLY592H, HIS586H, ILE590H, LEU589H, LYS503A, LYS591H, SER462H, SER531A, VAL536A, VAL587H
• B-D: ALA456D, ALA458D, ALA508B, ALA538B, ARG249D, ARG537B, ARG539B, ASP463D, ASP511B, GLU455D, GLU459D, GLU535B, GLY540B, GLY592D, HIS586D, ILE590D, LEU589D, LYS503B, LYS591D, SER462D, VAL536B, VAL587D
• B-F: ALA227B, ALA227F, ALA242B, ALA262B, ALA262F, ALA393B, ALA439B, ALA439F, ARG249F, ARG270B, ARG443B, ARG443F, ASN261B, ASN261F, ASN265B, ASN392B, ASP223B, ASP223F, ASP241B, ASP244B, ASP277B, ASP451B, ASP451F, GLN253F, GLN259B, GLN259F, GLN275B, GLN438B, GLN438F, GLN446B, GLN446F, GLN450F, GLN549F, GLU228B, GLU228F, GLU258B, GLU258F, GLU445B, GLU445F, GLU568F, GLY226B, GLY243B, GLY246B, GLY246F, GLY269B, GLY274B, GLY274F, GLY394B, GLY436F, HIS273B, HIS435B, HIS435F, HIS566F, ILE247B, ILE247F, ILE256F, ILE263B, ILE271B, ILE271F, ILE444B, ILE444F, ILE571F, LEU267B, LEU267F, LEU437B, LEU437F, LEU440B, LEU440F, LEU448B, LEU448F, LYS230F, LYS245B, LYS245F, LYS254B, LYS254F, LYS264B, LYS264F, LYS403B, LYS452B, LYS452F, MET447F, PHE575F, PRO260B, PRO260F, PRO441B, PRO441F, PRO565F, SER272B, SER442B, SER442F, SER449B, SER449F, THR225B, THR225F, THR268B, TYR248B, TYR248F, TYR257B, TYR257F, VAL229F, VAL434B, VAL434F, VAL567F
• B-G: ALA456B, ALA458B, ALA508G, ALA538G, ARG249B, ARG537G, ARG539G, ASP463B, ASP511G, GLU455B, GLU459B, GLY540G, GLY592B, HIS586B, ILE590B, LEU589B, LYS503G, LYS591B, SER462B, VAL536G, VAL587B
• B-H: ALA13H, ALA242B, ALA242H, ALA588B, ALA588H, ALA602B, ALA602H, ALA8B, ALA8H, ARG10B, ARG10H, ARG201B, ARG201H, ARG202B, ARG202H, ARG216B, ARG216H, ARG217B, ARG217H, ARG21B, ARG21H, ARG22B, ARG22H, ARG249B, ARG249H, ARG599B, ARG599H, ASN187B, ASN187H, ASN237B, ASN237H, ASN600B, ASN600H, ASP11B, ASP11H, ASP241B, ASP241H, ASP244H, ASP594B, ASP594H, ASP596B, ASP596H, GLN239B, GLN239H, GLN253H, GLN597B, GLN597H, GLN9B, GLN9H, GLU14B, GLU14H, GLU186B, GLU186H, GLU18B, GLU18H, GLU235B, GLU235H, GLY183B, GLY183H, GLY185B, GLY185H, GLY19B, GLY19H, GLY243B, GLY243H, GLY246H, GLY592B, GLY592H, GLY65B, GLY65H, GLY66B, GLY66H, HIS250B, HIS250H, HIS64B, HIS64H, ILE15B, ILE15H, ILE234B, ILE234H, ILE247H, ILE397B, ILE397H, ILE489B, ILE489H, ILE590B, ILE590H, LEU16H, LEU17H, LEU182B, LEU182H, LEU196B, LEU196H, LEU197B, LEU197H, LEU238B, LEU238H, LEU589B, LEU589H, LEU601B, LEU601H, LYS245B, LYS245H, LYS254H, LYS591B, LYS591H, LYS603B, MET184B, MET184H, PHE188B, PHE188H, PHE203B, PRO198B, PRO198H, PRO598B, PRO598H, SER236B, SER236H, SER462B, SER462H, SER490B, SER490H, SER604B, THR200B, THR200H, THR593B, THR593H, THR606B, TYR240B, TYR240H, TYR248B, TYR248H, TYR251B, TYR251H, TYR491B, TYR491H, TYR585B, TYR585H, VAL12B, VAL12H, VAL199B, VAL199H, VAL399B, VAL399H, VAL595B, VAL595H, VAL607B
• C-D: ALA299C, ALA299D, ALA318C, ALA318D, ALA327C, ALA327D, ALA336C, ALA336D, ALA353C, ALA353D, ALA400C, ALA400D, ALA467C, ALA467D, ALA483C, ALA483D, ALA494C, ALA494D, ALA496C, ALA496D, ALA498C, ALA498D, ALA499C, ALA499D, ALA508C, ALA508D, ALA512D, ALA538C, ALA538D, ALA602C, ALA602D, ARG311C, ARG311D, ARG331C, ARG331D, ARG333C, ARG333D, ARG338C, ARG338D, ARG339C, ARG339D, ARG421C, ARG421D, ARG472C, ARG472D, ARG537C, ARG537D, ARG539C, ARG539D, ARG599C, ARG599D, ASN305C, ASN305D, ASN340C, ASN522C, ASN522D, ASN532C, ASN532D, ASN600C, ASN600D, ASP323C, ASP323D, ASP354C, ASP354D, ASP474C, ASP474D, ASP511C, ASP511D, ASP513C, ASP513D, CYS300C, CYS300D, CYS322C, CYS322D, GLN296C, GLN296D, GLN475C, GLN475D, GLU293C, GLU293D, GLU315C, GLU315D, GLU325C, GLU325D, GLU329C, GLU329D, GLU488C, GLU488D, GLU495C, GLU495D, GLU501C, GLU501D, GLU524C, GLU524D, GLU534C, GLU534D, GLU535C, GLU535D, GLU608C, GLU608D, GLY301C, GLY301D, GLY319C, GLY319D, GLY471C, GLY471D, GLY473C, GLY473D, GLY500C, GLY500D, GLY505C, GLY505D, HIS294C, HIS294D, HIS465C, HIS465D, HIS466C, HIS466D, HIS493C, HIS493D, HIS504C, HIS504D, ILE295C, ILE295D, ILE320C, ILE320D, ILE326C, ILE326D, ILE429C, ILE429D, ILE489C, ILE489D, ILE492C, ILE492D, ILE510C, ILE510D, ILE533C, ILE533D, LEU317C, LEU317D, LEU422C, LEU422D, LEU425C, LEU425D, LEU468C, LEU468D, LEU480C, LEU480D, LEU484C, LEU484D, LEU486C, LEU486D, LEU502C, LEU502D, LEU507C, LEU507D, LEU509C, LEU509D, LEU525C, LEU525D, LEU601C, LEU601D, LYS334C, LYS334D, LYS423C, LYS464C, LYS464D, LYS487C, LYS487D, LYS503C, LYS503D, LYS528C, LYS528D, LYS591D, LYS603C, LYS603D, MET308C, MET308D, MET514C, MET514D, PHE314C, PHE314D, PHE330C, PHE330D, PHE469C, PHE469D, PRO321C, PRO321D, PRO477C, PRO477D, PRO506C, PRO506D, PRO598C, PRO598D, SER303C, SER303D, SER316C, SER316D, SER328C, SER328D, SER335C, SER335D, SER490C, SER490D, SER531C, SER531D, SER604C, SER604D, THR302C, THR302D, THR352C, THR352D, THR355C, THR355D, THR606C, THR606D, TRP313C, TRP313D, TYR304C, TYR304D, TYR312C, TYR312D, TYR332C, TYR332D, TYR476C, TYR476D, TYR491C, TYR491D, TYR497C, TYR497D, VAL324C, VAL324D, VAL337C, VAL337D, VAL399C, VAL399D, VAL536C, VAL536D, VAL605C, VAL605D, VAL607C, VAL607D
• C-G: ALA13C, ALA13G, ALA242G, ALA588C, ALA588G, ALA602C, ALA602G, ALA8C, ALA8G, ARG10C, ARG10G, ARG201C, ARG201G, ARG202C, ARG202G, ARG216C, ARG216G, ARG217C, ARG217G, ARG21C, ARG21G, ARG22C, ARG22G, ARG249C, ARG249G, ARG599C, ARG599G, ASN187C, ASN237G, ASN600C, ASN600G, ASP11C, ASP11G, ASP233C, ASP244C, ASP594C, ASP594G, ASP596C, ASP596G, GLN232C, GLN597C, GLN597G, GLN9C, GLN9G, GLU14C, GLU14G, GLU186C, GLU186G, GLU18C, GLU18G, GLU235C, GLU235G, GLU59C, GLU608G, GLY183C, GLY183G, GLY185C, GLY185G, GLY19C, GLY19G, GLY243G, GLY592C, GLY592G, GLY65C, GLY65G, GLY66C, HIS250C, HIS250G, HIS64C, HIS64G, ILE15C, ILE15G, ILE234C, ILE397C, ILE397G, ILE489C, ILE489G, ILE590C, ILE590G, LEU16C, LEU16G, LEU17C, LEU17G, LEU182C, LEU182G, LEU197C, LEU197G, LEU238G, LEU589C, LEU589G, LEU601C, LEU601G, LYS245C, LYS245G, LYS591C, LYS591G, LYS603C, LYS603G, MET184C, MET184G, PHE188C, PHE188G, PRO198C, PRO198G, PRO598C, PRO598G, PRO62C, SER236C, SER462C, SER462G, SER490C, SER490G, THR200C, THR200G, THR593C, THR593G, THR606G, TYR248C, TYR248G, TYR251C, TYR251G, TYR491C, TYR491G, TYR585C, TYR585G, VAL12C, VAL12G, VAL199C, VAL199G, VAL399C, VAL399G, VAL595C, VAL595G, VAL607G
• C-H: ALA456C, ALA458C, ALA508H, ALA512H, ALA538H, ALA588C, ARG249C, ARG537H, ARG539H, ASP460C, ASP463C, ASP511H, GLN232C, GLU455C, GLU459C, GLU535H, GLY540H, GLY592C, HIS586C, ILE510H, ILE590C, LEU589C, LYS503H, LYS591C, PHE461C, SER462C, SER531H, VAL536H, VAL587C
• D-G: ALA456G, ALA458G, ALA508D, ALA538D, ARG249G, ARG537D, ARG539D, ASP463G, ASP511D, GLU455G, GLU459G, GLY540D, GLY592G, HIS586G, ILE590G, LEU589G, LYS503D, LYS591G, SER462G, VAL536D, VAL587G
• E-F: ALA299E, ALA299F, ALA318E, ALA318F, ALA327E, ALA327F, ALA336E, ALA336F, ALA353E, ALA353F, ALA400E, ALA400F, ALA467E, ALA467F, ALA483E, ALA483F, ALA494E, ALA494F, ALA496E, ALA496F, ALA498E, ALA498F, ALA499E, ALA499F, ALA508E, ALA508F, ALA512F, ALA538E, ALA538F, ALA602E, ALA602F, ARG311E, ARG311F, ARG331E, ARG331F, ARG333E, ARG333F, ARG338E, ARG338F, ARG339E, ARG339F, ARG421E, ARG421F, ARG472E, ARG472F, ARG537E, ARG537F, ARG539E, ARG539F, ARG599E, ARG599F, ASN305E, ASN305F, ASN340E, ASN340F, ASN522E, ASN522F, ASN532E, ASN532F, ASN600E, ASN600F, ASP323E, ASP323F, ASP354E, ASP354F, ASP474E, ASP474F, ASP511E, ASP511F, ASP513E, ASP513F, CYS300E, CYS300F, CYS322E, CYS322F, GLN296E, GLN296F, GLN475E, GLN475F, GLU293E, GLU293F, GLU315E, GLU315F, GLU325E, GLU325F, GLU329E, GLU329F, GLU488E, GLU488F, GLU495E, GLU495F, GLU501E, GLU501F, GLU524E, GLU524F, GLU527E, GLU527F, GLU534E, GLU534F, GLU535E, GLU535F, GLU608E, GLU608F, GLY301E, GLY301F, GLY319E, GLY319F, GLY424E, GLY471E, GLY471F, GLY473E, GLY473F, GLY500E, GLY500F, GLY505E, GLY505F, HIS294E, HIS294F, HIS465E, HIS465F, HIS466E, HIS466F, HIS493E, HIS493F, HIS504E, HIS504F, ILE295E, ILE295F, ILE320E, ILE320F, ILE326E, ILE326F, ILE429E, ILE429F, ILE489E, ILE489F, ILE492E, ILE492F, ILE510E, ILE510F, ILE533E, ILE533F, LEU298E, LEU317E, LEU317F, LEU422E, LEU422F, LEU425E, LEU425F, LEU468E, LEU468F, LEU480E, LEU480F, LEU484E, LEU484F, LEU486E, LEU486F, LEU502E, LEU502F, LEU507E, LEU507F, LEU509E, LEU509F, LEU525E, LEU525F, LEU601E, LEU601F, LYS334E, LYS334F, LYS423E, LYS464E, LYS464F, LYS485E, LYS487E, LYS487F, LYS503E, LYS503F, LYS528E, LYS528F, LYS591E, LYS603E, LYS603F, MET308E, MET308F, MET514E, MET514F, PHE314E, PHE314F, PHE330E, PHE330F, PHE469E, PHE469F, PRO321E, PRO321F, PRO477E, PRO477F, PRO506E, PRO506F, PRO598E, PRO598F, SER303E, SER303F, SER316E, SER316F, SER328E, SER328F, SER335E, SER335F, SER349E, SER490E, SER490F, SER531E, SER531F, SER604E, SER604F, THR302E, THR302F, THR352E, THR352F, THR355E, THR355F, THR606E, THR606F, TRP313E, TRP313F, TYR304E, TYR304F, TYR312E, TYR312F, TYR332E, TYR332F, TYR476E, TYR476F, TYR491E, TYR491F, TYR497E, TYR497F, VAL324E, VAL324F, VAL337E, VAL337F, VAL399E, VAL399F, VAL536E, VAL536F, VAL605E, VAL605F, VAL607E, VAL607F
• F-H: ALA427F, ARG383H, ASP244H, ASP426F, GLU351H, GLY274F, GLY378H, GLY424F, HIS273F, HIS431F, ILE429F, LEU425F, PRO377H, SER379H, SER380H, SER428F, THR395H, VAL376H
• G-H: ALA299G, ALA299H, ALA318G, ALA318H, ALA327G, ALA327H, ALA336G, ALA336H, ALA353G, ALA353H, ALA400G, ALA400H, ALA467G, ALA467H, ALA483G, ALA483H, ALA494G, ALA494H, ALA496G, ALA496H, ALA498G, ALA498H, ALA499G, ALA499H, ALA508G, ALA508H, ALA512G, ALA538G, ALA538H, ALA602G, ALA602H, ARG311G, ARG311H, ARG331G, ARG331H, ARG333G, ARG333H, ARG338G, ARG338H, ARG339G, ARG339H, ARG421G, ARG421H, ARG472G, ARG472H, ARG537G, ARG537H, ARG539G, ARG539H, ARG599G, ARG599H, ASN305G, ASN305H, ASN340H, ASN522G, ASN522H, ASN532G, ASN532H, ASN600G, ASN600H, ASP323G, ASP323H, ASP354G, ASP354H, ASP474G, ASP474H, ASP511G, ASP511H, ASP513G, ASP513H, CYS300G, CYS300H, CYS322G, CYS322H, GLN296G, GLN296H, GLN475G, GLN475H, GLU293G, GLU293H, GLU315G, GLU315H, GLU325G, GLU325H, GLU329G, GLU329H, GLU488G, GLU488H, GLU495G, GLU495H, GLU501G, GLU501H, GLU524G, GLU524H, GLU534G, GLU534H, GLU535G, GLU535H, GLU608G, GLU608H, GLY301G, GLY301H, GLY319G, GLY319H, GLY471G, GLY471H, GLY473G, GLY473H, GLY500G, GLY500H, GLY505G, GLY505H, HIS294G, HIS294H, HIS465G, HIS465H, HIS466G, HIS466H, HIS493G, HIS493H, HIS504G, HIS504H, ILE295G, ILE295H, ILE320G, ILE320H, ILE326G, ILE326H, ILE429G, ILE429H, ILE489G, ILE489H, ILE492G, ILE492H, ILE510G, ILE510H, ILE533G, ILE533H, LEU298G, LEU317G, LEU317H, LEU422G, LEU422H, LEU425G, LEU425H, LEU468G, LEU468H, LEU480G, LEU480H, LEU484G, LEU484H, LEU486G, LEU486H, LEU502G, LEU502H, LEU507G, LEU507H, LEU509G, LEU509H, LEU525G, LEU525H, LEU601G, LEU601H, LYS334G, LYS334H, LYS464G, LYS464H, LYS485H, LYS487G, LYS487H, LYS503G, LYS503H, LYS528G, LYS528H, LYS603G, LYS603H, MET308G, MET308H, MET514G, MET514H, PHE314G, PHE314H, PHE330G, PHE330H, PHE469G, PHE469H, PRO321G, PRO321H, PRO477G, PRO477H, PRO506G, PRO506H, PRO598G, PRO598H, SER303G, SER303H, SER316G, SER316H, SER328G, SER328H, SER335G, SER335H, SER349G, SER490G, SER490H, SER531G, SER531H, SER604G, SER604H, THR302G, THR302H, THR352G, THR352H, THR355G, THR355H, THR606G, THR606H, TRP313G, TRP313H, TYR304G, TYR304H, TYR312G, TYR312H, TYR332G, TYR332H, TYR476G, TYR476H, TYR491G, TYR491H, TYR497G, TYR497H, VAL324G, VAL324H, VAL337G, VAL337H, VAL399G, VAL399H, VAL536G, VAL536H, VAL605G, VAL605H, VAL607G, VAL607H