3ONW

structure of a g-alpha-i1 mutant with enhanced affinity for the rgs14 goloco motif.

• Total interactions analyzed: 6
• Total true interactions: 5
• Strongest Interaction:
  • Chains: B-D
  • Int. Res.: 151
  • Norm. En. per Res.: -4.059
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-29.7362	21.7385	-157.035	-165.0327	78	7	2	6823	2	43	48
A-C	-101.0289	-14.7781	-482.521	-598.3279	156	18	15	19932	4	39	27
A-D	0.0	3.7384	-3.0038	0.7346	6	0	0	153	0	1	4
B-C	0.0	0.0	-0.0096	-0.0096	4	0	0	5	0	0	1
B-D	-81.9409	-54.0213	-476.953	-612.9152	151	18	15	19797	4	41	28

Interface residues

• A-B: ALA138A, ALA235A, ALA235B, ALA87A, ARG142A, ARG142B, ARG144A, ARG144B, ARG242A, ARG90A, ASN141A, ASN241A, ASN241B, ASN294A, ASN294B, ASP231A, ASP231B, ASP237A, ASP237B, ASP251B, ASP94A, CYS286A, CYS286B, GLN306B, GLU145A, GLU145B, GLU236A, GLU236B, GLU238A, GLU238B, GLU239A, GLU239B, GLU289B, GLY135A, GLY89A, GLY96A, HIS244A, HIS244B, ILE285A, ILE285B, ILE93A, LEU232A, LEU232B, LEU234A, LEU234B, LEU283A, LEU283B, LEU310B, LEU91A, LYS248B, LYS277B, LYS279B, LYS280A, LYS280B, LYS312B, LYS92A, MET240A, MET240B, MET243A, MET247B, MET88A, PRO282A, PRO282B, PRO288A, PRO288B, SER134A, SER281A, SER281B, THR284A, THR284B, TYR146A, TYR230A, TYR287A, TYR287B, TYR290B, TYR302B, VAL233A, VAL233B
• A-C: ALA101A, ALA104A, ALA111A, ALA113A, ALA114A, ALA152A, ALA235A, ALA41A, ALA512C, ALA71A, ALA83A, ALA87A, ARG100A, ARG105A, ARG176A, ARG178A, ARG205A, ARG208A, ARG242A, ARG506C, ARG516C, ARG520C, ARG86A, ARG90A, ASN149A, ASN241A, ASN255A, ASN256A, ASN505C, ASN76A, ASP102A, ASP103A, ASP150A, ASP200A, ASP229A, ASP237A, ASP251A, ASP514C, ASP523C, ASP94A, CYS214A, CYS224A, CYS254A, GLN106A, GLN204A, GLN508C, GLN515C, GLN531C, GLN68A, GLN79A, GLU116A, GLU207A, GLU238A, GLU239A, GLU245A, GLU43A, GLU498C, GLU502C, GLU522C, GLU528C, GLY112A, GLY117A, GLY202A, GLY203A, GLY40A, GLY42A, GLY45A, GLY499C, GLY511C, GLY517C, GLY89A, HIS244A, HIS513C, ILE127A, ILE212A, ILE221A, ILE253A, ILE497C, ILE78A, ILE81A, ILE82A, ILE84A, ILE85A, ILE93A, LEU107A, LEU110A, LEU123A, LEU130A, LEU147A, LEU148A, LEU232A, LEU249A, LEU37A, LEU38A, LEU39A, LEU500C, LEU503C, LEU504C, LEU518C, LEU519C, LEU524C, LEU526C, LEU530C, LYS180A, LYS209A, LYS210A, LYS248A, LYS257A, LYS270A, LYS46A, LYS51A, LYS521C, LYS70A, LYS92A, MET119A, MET240A, MET243A, MET247A, MET88A, PHE108A, PHE215A, PHE223A, PHE250A, PHE259A, PHE529C, PHE95A, PRO527C, SER151A, SER206A, SER246A, SER252A, SER44A, SER47A, SER509C, SER510C, SER75A, SER80A, THR177A, THR181A, THR48A, THR77A, TRP211A, TRP258A, TYR146A, TYR69A, TYR74A, VAL109A, VAL136A, VAL179A, VAL201A, VAL225A, VAL501C, VAL507C, VAL525C, VAL72A, VAL73A
• A-D: ARG506D, GLU289A, GLU502D, PRO288A, THR284A, TYR287A
• B-C: ASN294B, GLU528C, PHE529C, PRO282B
• B-D: ALA101B, ALA104B, ALA111B, ALA113B, ALA114B, ALA152B, ALA235B, ALA41B, ALA512D, ALA71B, ALA83B, ALA87B, ARG105B, ARG176B, ARG178B, ARG205B, ARG208B, ARG242B, ARG506D, ARG516D, ARG520D, ARG86B, ARG90B, ASN149B, ASN255B, ASN256B, ASN505D, ASN76B, ASP150B, ASP200B, ASP229B, ASP237B, ASP251B, ASP496D, ASP514D, ASP523D, ASP94B, CYS214B, CYS224B, CYS254B, GLN106B, GLN204B, GLN508D, GLN515D, GLN68B, GLN79B, GLU116B, GLU207B, GLU238B, GLU239B, GLU245B, GLU43B, GLU498D, GLU502D, GLU522D, GLU528D, GLY112B, GLY117B, GLY202B, GLY203B, GLY40B, GLY42B, GLY45B, GLY499D, GLY511D, GLY517D, GLY89B, HIS244B, HIS513D, ILE184B, ILE212B, ILE221B, ILE253B, ILE497D, ILE78B, ILE81B, ILE82B, ILE84B, ILE85B, ILE93B, LEU107B, LEU110B, LEU123B, LEU147B, LEU148B, LEU232B, LEU249B, LEU37B, LEU38B, LEU39B, LEU500D, LEU503D, LEU504D, LEU518D, LEU519D, LEU524D, LEU526D, LEU91B, LYS180B, LYS209B, LYS210B, LYS248B, LYS257B, LYS270B, LYS46B, LYS51B, LYS521D, LYS70B, LYS92B, MET119B, MET240B, MET247B, MET88B, PHE108B, PHE199B, PHE215B, PHE223B, PHE250B, PHE259B, PHE529D, PHE95B, PRO527D, SER151B, SER206B, SER246B, SER252B, SER44B, SER47B, SER509D, SER510D, SER75B, SER80B, THR177B, THR181B, THR182B, THR48B, THR77B, TRP211B, TRP258B, TYR146B, TYR69B, TYR74B, VAL109B, VAL179B, VAL201B, VAL225B, VAL501D, VAL507D, VAL525D, VAL72B, VAL73B