3OJV

crystal structure of fgf1 complexed with the ectodomain of fgfr1c exhibiting an ordered ligand specificity-determining betac'-betae loop

• Total interactions analyzed: 6
• Total true interactions: 5
• Strongest Interaction:
  • Chains: A-C
  • Int. Res.: 122
  • Norm. En. per Res.: -3.3739
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	0.0	0.0	-0.114	-0.114	7	0	0	61	0	0	6
A-C	-55.1319	-20.67	-335.818	-411.6199	122	14	7	13647	1	43	43
A-D	0.0	0.0	-2.6536	-2.6536	20	0	0	283	0	7	5
B-C	0.0	0.0	-2.8293	-2.8293	19	0	0	293	0	8	5
B-D	-49.7451	-24.1123	-334.002	-407.8595	125	20	7	13867	2	42	44

Interface residues

• A-B: ARG137B, ASN129A, ASN129B, LYS127A, LYS127B, LYS128A, LYS128B
• A-C: ALA167C, ALA170C, ALA171C, ALA314C, ALA343C, ALA63A, ARG103A, ARG250C, ARG50A, ARG52A, ASN107A, ASN110A, ASN22A, ASN317C, ASN33A, ASN345C, ASN95A, ASP246C, ASP282C, ASP320C, CYS277C, CYS31A, CYS98A, GLN244C, GLN258C, GLN284C, GLN288C, GLN60A, GLU102A, GLU105A, GLU106A, GLU159C, GLU162C, GLU249C, GLU322C, GLU324C, GLU64A, GLU68A, GLY21A, GLY315C, GLY344C, GLY348C, GLY34A, GLY35A, GLY67A, HIS108A, HIS166C, HIS253C, HIS286C, HIS36A, ILE256C, ILE287C, ILE347C, ILE71A, LEU101A, LEU104A, LEU146A, LEU148A, LEU150A, LEU165C, LEU257C, LEU28A, LEU29A, LEU342C, LEU349C, LEU61A, LEU99A, LYS128A, LYS143A, LYS160C, LYS163C, LYS164C, LYS172C, LYS225C, LYS24A, LYS25A, LYS278C, LYS27A, LYS321C, LYS72A, MET161C, MET323C, PHE147A, PHE37A, PRO149A, PRO151A, PRO169C, PRO252C, PRO255C, PRO283C, PRO285C, PRO94A, SER153A, SER251C, SER281C, SER32A, SER346C, SER62A, SER65A, THR111A, THR173C, THR313C, THR318C, THR319C, THR49A, THR93A, TYR109A, TYR112A, TYR23A, TYR280C, TYR30A, TYR70A, TYR79A, VAL168C, VAL174C, VAL220C, VAL247C, VAL248C, VAL279C, VAL316C, VAL66A, VAL69A
• A-D: ARG134A, ARG148D, ASN129A, ASP43A, ASP47A, GLU159D, GLY182D, LEU41A, LYS127A, LYS160D, PRO42A, SER131A, SER157D, SER181D, THR156D, THR183D, THR212D, THR45A, TYR154D, VAL151D
• B-C: ARG134B, ASN129B, ASP43B, ASP47B, GLU159C, GLY182C, LEU41B, LYS127B, LYS160C, PRO42B, SER131B, SER157C, SER181C, THR156C, THR183C, THR212C, THR45B, TYR154C, VAL151C
• B-D: ALA167D, ALA170D, ALA171D, ALA314D, ALA343D, ALA63B, ARG103B, ARG250D, ARG50B, ARG52B, ASN107B, ASN110B, ASN22B, ASN317D, ASN33B, ASN345D, ASN95B, ASP246D, ASP282D, ASP320D, CYS277D, CYS31B, CYS98B, GLN244D, GLN258D, GLN284D, GLN288D, GLN60B, GLU102B, GLU105B, GLU106B, GLU159D, GLU162D, GLU249D, GLU322D, GLU324D, GLU64B, GLU68B, GLY21B, GLY315D, GLY344D, GLY348D, GLY34B, GLY35B, GLY67B, HIS108B, HIS166D, HIS253D, HIS286D, HIS36B, ILE256D, ILE287D, ILE347D, ILE71B, LEU101B, LEU104B, LEU146B, LEU148B, LEU150B, LEU165D, LEU245D, LEU257D, LEU28B, LEU29B, LEU342D, LEU349D, LEU59B, LEU61B, LEU99B, LYS128B, LYS143B, LYS160D, LYS163D, LYS164D, LYS172D, LYS225D, LYS24B, LYS25B, LYS278D, LYS27B, LYS321D, LYS72B, MET161D, MET323D, PHE147B, PHE37B, PRO149B, PRO151B, PRO169D, PRO252D, PRO255D, PRO283D, PRO285D, PRO94B, SER153B, SER251D, SER281D, SER32B, SER346D, SER62B, SER65B, THR111B, THR173D, THR313D, THR318D, THR319D, THR49B, THR93B, TYR109B, TYR112B, TYR23B, TYR280D, TYR30B, TYR70B, TYR79B, VAL168D, VAL174D, VAL220D, VAL247D, VAL248D, VAL279D, VAL316D, VAL325D, VAL66B, VAL69B