3OJ2

crystal structure of fgf1 complexed with the ectodomain of fgfr2b harboring the a172f pfeiffer syndrome mutation

• Total interactions analyzed: 6
• Total true interactions: 5
• Strongest Interaction:
  • Chains: A-C
  • Int. Res.: 126
  • Norm. En. per Res.: -3.7239
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-C	-57.1243	-15.2413	-396.845	-469.2106	126	21	9	15422	3	38	39
A-D	-3.502	7.2523	-23.0656	-19.3154	14	0	0	702	0	5	2
B-C	0.0	2.5161	-15.8976	-13.3815	14	1	0	633	0	5	2
B-D	-72.5481	2.1058	-390.055	-460.4973	128	23	8	15436	3	38	39
C-D	-75.9473	3.601	-200.915	-273.2613	115	12	4	8386	0	20	17

Interface residues

• A-C: ALA168C, ALA171C, ALA284C, ALA322C, ALA63A, ARG103A, ARG165C, ARG251C, ARG50A, ARG52A, ASN107A, ASN110A, ASN129A, ASN173C, ASN22A, ASN318C, ASN321C, ASN33A, ASN344C, ASN95A, ASP247C, ASP283C, ASP51A, CYS278C, CYS31A, CYS98A, GLN259C, GLN285C, GLN289C, GLN348C, GLN60A, GLU102A, GLU105A, GLU106A, GLU160C, GLU163C, GLU250C, GLU323C, GLU64A, GLU68A, GLY21A, GLY316C, GLY347C, GLY34A, GLY35A, GLY67A, HIS108A, HIS167C, HIS245C, HIS254C, HIS287C, HIS314C, HIS36A, ILE257C, ILE288C, ILE317C, ILE346C, ILE71A, LEU101A, LEU104A, LEU146A, LEU148A, LEU150A, LEU166C, LEU246C, LEU258C, LEU262C, LEU28A, LEU29A, LEU61A, LEU99A, LYS128A, LYS143A, LYS161C, LYS164C, LYS226C, LYS24A, LYS25A, LYS279C, LYS27A, LYS341C, LYS72A, MET162C, PHE147A, PHE172C, PHE37A, PRO149A, PRO151A, PRO170C, PRO19A, PRO20A, PRO253C, PRO256C, PRO286C, PRO94A, SER153A, SER252C, SER282C, SER315C, SER319C, SER320C, SER32A, SER343C, SER62A, SER65A, THR111A, THR174C, THR49A, THR93A, TYR109A, TYR112A, TYR23A, TYR281C, TYR30A, TYR345C, TYR70A, TYR79A, VAL169C, VAL175C, VAL248C, VAL249C, VAL280C, VAL324C, VAL342C, VAL66A, VAL69A
• A-D: ALA349D, ARG255D, ASN107A, GLN348D, GLU105A, GLU106A, GLY347D, HIS108A, HIS254D, ILE257D, ILE346D, PRO253D, PRO256D, TYR109A
• B-C: ALA349C, ARG255C, ASN107B, GLN348C, GLU105B, GLU106B, GLY347C, HIS108B, HIS254C, ILE257C, ILE346C, PRO253C, PRO256C, TYR109B
• B-D: ALA168D, ALA171D, ALA284D, ALA322D, ALA63B, ARG103B, ARG165D, ARG251D, ARG50B, ARG52B, ASN107B, ASN110B, ASN173D, ASN22B, ASN318D, ASN321D, ASN33B, ASN344D, ASN95B, ASP247D, ASP283D, ASP51B, CYS278D, CYS31B, CYS98B, GLN259D, GLN285D, GLN289D, GLN348D, GLN60B, GLU102B, GLU105B, GLU106B, GLU160D, GLU163D, GLU250D, GLU323D, GLU64B, GLU68B, GLY21B, GLY316D, GLY347D, GLY34B, GLY35B, GLY67B, HIS108B, HIS167D, HIS245D, HIS254D, HIS287D, HIS314D, HIS36B, ILE257D, ILE288D, ILE317D, ILE346D, ILE71B, LEU101B, LEU104B, LEU146B, LEU148B, LEU150B, LEU166D, LEU246D, LEU258D, LEU262D, LEU28B, LEU29B, LEU61B, LEU99B, LYS128B, LYS143B, LYS161D, LYS164D, LYS226D, LYS24B, LYS25B, LYS279D, LYS27B, LYS341D, LYS72B, MET162D, PHE147B, PHE172D, PHE177D, PHE37B, PRO149B, PRO151B, PRO170D, PRO19B, PRO20B, PRO253D, PRO256D, PRO286D, PRO94B, SER153B, SER252D, SER282D, SER315D, SER319D, SER320D, SER32B, SER343D, SER62B, SER65B, THR111B, THR174D, THR49B, THR93B, TYR109B, TYR112B, TYR23B, TYR244D, TYR281D, TYR30B, TYR345D, TYR70B, TYR79B, VAL169D, VAL175D, VAL221D, VAL248D, VAL249D, VAL280D, VAL324D, VAL342D, VAL66B, VAL69B
• C-D: ALA171C, ALA171D, ALA260C, ALA260D, ALA264C, ALA264D, ALA349C, ALA349D, ALA353C, ALA353D, ARG203C, ARG203D, ARG210C, ARG210D, ARG251C, ARG251D, ARG255C, ARG255D, ASN173C, ASN173D, ASN211C, ASN211D, ASN265C, ASN265D, ASN350C, ASN350D, ASP225C, ASP225D, GLN200C, GLN200D, GLN212C, GLN212D, GLN259C, GLN259D, GLN351C, GLN351D, GLU219C, GLU219D, GLU250C, GLU250D, GLU337C, GLU337D, GLY205C, GLY205D, GLY206C, GLY206D, GLY261C, GLY261D, GLY336C, GLY336D, HIS213C, HIS213D, HIS254C, HIS254D, HIS293C, ILE204C, ILE204D, ILE217C, ILE217D, ILE257C, ILE257D, ILE339C, ILE346C, ILE346D, LEU258C, LEU258D, LEU262C, LEU262D, LEU355D, LYS176C, LYS176D, LYS208C, LYS208D, MET218C, MET218D, PHE172C, PHE172D, PHE276C, PHE276D, PRO170C, PRO170D, PRO253C, PRO253D, PRO256C, PRO256D, PRO263C, PRO263D, SER220C, SER220D, SER252C, SER252D, SER352C, SER352D, THR174C, THR174D, THR356D, TRP354C, TRP354D, TYR207C, TYR207D, TYR281C, TYR281D, TYR301C, TYR301D, TYR338C, TYR338D, VAL169C, VAL209C, VAL209D, VAL221C, VAL221D, VAL222C, VAL222D, VAL277C, VAL277D