3OFL

crystal structure of humanpapillomavirus18 (hpv18) capsid l1 pentamers bound to heparin oligosaccharides

• Total interactions analyzed: 105
• Total true interactions: 41
• Strongest Interaction:
  • Chains: M-N
  • Int. Res.: 294
  • Norm. En. per Res.: -3.6401
• Hub Node: F(7)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-109.3337	-18.4609	-863.034	-990.8286	292	55	16	36740	7	69	72
A-C	-6.9025	0.0	-20.835	-27.7375	17	4	1	1292	0	2	1
A-D	0.0	0.0	-28.8077	-28.8077	15	0	1	1186	0	2	1
A-E	-123.1718	-47.0098	-881.283	-1051.4645	291	38	16	36653	8	70	70
B-C	-139.5014	-36.9466	-891.164	-1067.612	298	49	16	37147	9	71	71
B-D	0.0	0.0	-21.3291	-21.3291	15	0	1	1067	0	2	2
B-E	0.0	0.0	-25.3626	-25.3626	16	0	1	1090	0	2	1
B-H	0.0	0.0	-0.1208	-0.1208	5	0	0	37	0	0	1
B-I	0.0	11.1178	-0.532	10.5859	11	0	0	89	0	1	4
B-J	-2.3758	-12.6991	-26.6136	-41.6886	29	11	0	1862	0	2	2
C-D	-112.6067	-27.566	-875.888	-1016.0606	295	38	17	36614	7	70	72
C-E	0.0	0.0	-21.5023	-21.5023	16	0	1	1038	0	2	1
C-G	0.0	0.0	-3.3181	-3.3181	9	4	0	171	0	0	1
C-I	0.0	-2.219	-6.195	-8.414	10	0	0	366	0	2	0
D-E	-117.3653	-44.1998	-850.136	-1011.7011	291	33	17	35541	7	71	69
F-G	-146.9142	-31.1854	-887.703	-1065.8027	298	64	18	37680	8	71	75
F-H	-8.3742	0.0	-28.2605	-36.6347	17	5	1	1527	0	2	1
F-I	-8.1563	0.0	-26.8225	-34.9788	16	5	1	1267	0	2	1
F-J	-92.9958	-39.9468	-818.071	-951.0136	287	57	16	36009	7	71	66
F-M	0.0	0.0	-0.0477	-0.0477	8	0	0	28	0	0	1
F-N	0.0	16.6229	-4.3332	12.2897	13	0	0	387	0	1	3
F-O	-2.278	-11.6303	-38.9752	-52.8834	27	9	0	1994	0	2	1
G-H	-136.0686	-29.2437	-861.449	-1026.7613	293	37	16	36022	7	70	70
G-I	0.0	0.0	-24.7788	-24.7788	15	2	1	1136	0	2	1
G-J	0.0	0.0	-27.6127	-27.6127	16	2	1	1231	0	2	1
G-L	0.0	0.0	-1.1325	-1.1325	11	8	0	411	0	0	1
G-M	0.0	0.0	-0.0019	-0.0019	2	0	0	1	0	0	2
G-N	0.0	-3.0674	-7.6064	-10.6738	13	1	0	451	0	2	0
H-I	-120.7471	-56.9327	-844.789	-1022.4689	291	45	16	36201	10	69	70
H-J	0.0	0.0	-23.8581	-23.8581	15	2	1	1155	0	2	1
I-J	-129.1432	-27.5052	-886.21	-1042.8584	293	42	16	36559	7	71	71
K-L	-117.425	-27.4892	-875.294	-1020.2082	296	43	16	36771	10	71	71
K-M	0.0	0.0	-28.0167	-28.0167	16	2	1	1219	0	2	1
K-N	0.0	0.0	-31.273	-31.273	16	1	1	1239	0	2	1
K-O	-116.3867	-24.7993	-866.697	-1007.883	291	35	17	35879	9	70	71
L-M	-129.0617	-44.4831	-859.836	-1033.3808	292	31	16	36007	8	70	70
L-N	0.0	0.0	-22.1809	-22.1809	15	0	1	1107	0	2	1
L-O	-8.2662	0.0	-30.7099	-38.9761	17	1	1	1247	0	2	2
M-N	-127.8528	-46.4814	-895.861	-1070.1952	294	47	16	36935	9	70	70
M-O	0.0	0.0	-26.8744	-26.8744	16	1	1	1146	0	2	2
N-O	-142.5318	-23.3436	-883.745	-1049.6204	297	41	18	36823	7	71	71

Interface residues

• A-B: ALA134A, ALA134B, ALA135B, ALA170B, ALA207B, ALA20B, ALA239B, ALA257B, ALA264B, ALA284B, ALA316B, ALA346A, ALA358A, ALA54A, ARG109A, ARG144A, ARG144B, ARG178B, ARG251B, ARG252B, ARG258A, ARG258B, ARG263B, ARG283B, ARG338A, ARG366A, ARG41A, ARG467A, ARG51A, ASN124B, ASN138B, ASN146A, ASN192B, ASN23B, ASN262B, ASN308A, ASN320B, ASN341A, ASN58A, ASP127A, ASP127B, ASP128A, ASP128B, ASP142A, ASP142B, ASP145A, ASP150A, ASP184B, ASP202B, ASP209B, ASP215A, ASP215B, ASP223A, ASP233B, ASP240B, ASP269B, ASP26B, ASP303A, ASP357A, ASP372A, ASP459A, ASP461A, ASP47A, CYS185B, CYS218A, CYS218B, CYS225A, CYS229B, CYS289B, CYS345A, GLN111A, GLN153A, GLN153B, GLN155B, GLN182B, GLN214A, GLN214B, GLN226A, GLN226B, GLN236B, GLN254B, GLN273B, GLN305A, GLN317B, GLN349A, GLN355A, GLN363A, GLN374A, GLN462A, GLN60A, GLU106A, GLU130B, GLU141A, GLU141B, GLU167B, GLU189B, GLU219B, GLU253B, GLU369A, GLU370A, GLY108A, GLY110A, GLY114A, GLY116A, GLY119A, GLY166B, GLY183B, GLY204B, GLY206B, GLY243B, GLY265B, GLY268B, GLY279B, GLY281B, GLY287B, GLY297A, GLY297B, GLY318B, GLY354A, GLY46A, GLY55A, GLY56A, GLY57A, HIS120A, HIS133A, HIS133B, HIS168B, HIS259A, HIS259B, HIS314B, HIS319B, HIS367A, ILE107A, ILE165B, ILE224A, ILE277B, ILE299A, ILE299B, ILE344A, ILE62A, LEU113A, LEU117A, LEU126B, LEU180B, LEU188B, LEU190B, LEU213B, LEU222A, LEU235B, LEU255B, LEU275B, LEU306B, LEU342A, LEU373A, LEU42A, LEU43A, LEU460A, LEU465A, LEU470A, LYS125A, LYS125B, LYS152B, LYS171B, LYS191B, LYS217A, LYS217B, LYS230B, LYS278B, LYS309A, LYS315B, LYS360A, LYS362A, LYS468A, LYS59A, LYS64A, MET208B, MET237B, MET246B, MET267B, MET282B, PHE122A, PHE122B, PHE210B, PHE256A, PHE256B, PHE260B, PHE307A, PHE361A, PHE50A, PRO112A, PRO121A, PRO179B, PRO186B, PRO187B, PRO221A, PRO232B, PRO241B, PRO272B, PRO286B, PRO293B, PRO295A, PRO295B, PRO351A, PRO353A, PRO464A, PRO48A, PRO53A, SER118A, SER131B, SER132A, SER132B, SER137A, SER140B, SER148A, SER175B, SER177B, SER181B, SER227A, SER238B, SER274B, SER285B, SER288B, SER292B, SER294A, SER294B, SER296A, SER296B, SER298A, SER298B, SER302A, SER304A, SER304B, SER339A, SER347A, SER350A, SER365A, SER40A, THR129B, THR136A, THR136B, THR154B, THR203B, THR212B, THR216A, THR216B, THR266B, THR270B, THR280B, THR301A, THR337A, THR340A, THR343A, THR348A, THR359A, THR44A, TRP169B, TRP261A, TRP261B, TYR123A, TYR123B, TYR205B, TYR231B, TYR234B, TYR242B, TYR276B, TYR291B, TYR356A, TYR364A, TYR371A, TYR391B, TYR463A, TYR49A, TYR70B, VAL115A, VAL139B, VAL143A, VAL143B, VAL147A, VAL149A, VAL201B, VAL21B, VAL220A, VAL220B, VAL22B, VAL271B, VAL290B, VAL300A, VAL352A, VAL368A, VAL45A, VAL471A, VAL52A
• A-C: ALA284C, ARG283C, ASP357A, GLN273C, GLN355A, GLY279C, GLY281C, GLY354A, ILE277C, LYS278C, PHE361A, PRO353A, SER347A, THR280C, TYR276C, TYR356A, VAL352A
• A-D: ALA284A, ARG283A, ASP357D, GLN355D, GLY279A, GLY281A, GLY354D, ILE277A, LYS278A, PHE361D, PRO353D, THR280A, TYR276A, TYR356D, VAL352D
• A-E: ALA134A, ALA134E, ALA135A, ALA135E, ALA170A, ALA207A, ALA20A, ALA239A, ALA257A, ALA264A, ALA284A, ALA316A, ALA346E, ALA358E, ALA54E, ARG109E, ARG144A, ARG144E, ARG178A, ARG251A, ARG252A, ARG258A, ARG258E, ARG263A, ARG283A, ARG338E, ARG366E, ARG41E, ARG467E, ARG51E, ASN124A, ASN146E, ASN192A, ASN23A, ASN262A, ASN308E, ASN320A, ASN341E, ASN58E, ASP127A, ASP127E, ASP128A, ASP128E, ASP142A, ASP142E, ASP145E, ASP150E, ASP184A, ASP202A, ASP209A, ASP215A, ASP215E, ASP223E, ASP233A, ASP240A, ASP269A, ASP26A, ASP303E, ASP357E, ASP372E, ASP459E, ASP461E, ASP47E, CYS185A, CYS218A, CYS218E, CYS225E, CYS229A, CYS289A, CYS345E, GLN111E, GLN153A, GLN153E, GLN182A, GLN214A, GLN214E, GLN226E, GLN236A, GLN254A, GLN254E, GLN273A, GLN305E, GLN317A, GLN349E, GLN355E, GLN363E, GLN374E, GLN462E, GLN60E, GLU106E, GLU130A, GLU141A, GLU141E, GLU167A, GLU189A, GLU219A, GLU253A, GLU369E, GLU370E, GLY108E, GLY110E, GLY114E, GLY116E, GLY119E, GLY183A, GLY204A, GLY206A, GLY243A, GLY265A, GLY268A, GLY279A, GLY281A, GLY287A, GLY297A, GLY297E, GLY318A, GLY354E, GLY46E, GLY55E, GLY56E, GLY57E, HIS120E, HIS133A, HIS133E, HIS168A, HIS259A, HIS259E, HIS314A, HIS319A, HIS367E, ILE107E, ILE165A, ILE224E, ILE277A, ILE299A, ILE299E, ILE344E, ILE62E, LEU113E, LEU117E, LEU126A, LEU126E, LEU180A, LEU188A, LEU190A, LEU213A, LEU222E, LEU235A, LEU255A, LEU275A, LEU306A, LEU342E, LEU373E, LEU42E, LEU43E, LEU460E, LEU465E, LEU470E, LYS125A, LYS125E, LYS152A, LYS171A, LYS191A, LYS217A, LYS217E, LYS230A, LYS278A, LYS309E, LYS315A, LYS360E, LYS362E, LYS468E, LYS59E, LYS64E, MET208A, MET237A, MET267A, MET282A, PHE122A, PHE122E, PHE210A, PHE256A, PHE256E, PHE260A, PHE260E, PHE307E, PHE361E, PHE50E, PRO112E, PRO121E, PRO179A, PRO186A, PRO187A, PRO221E, PRO232A, PRO241A, PRO272A, PRO286A, PRO293A, PRO295A, PRO295E, PRO351E, PRO353E, PRO464E, PRO48E, PRO53E, SER118E, SER131A, SER132A, SER132E, SER137E, SER140A, SER148E, SER175A, SER177A, SER181A, SER227E, SER238A, SER274A, SER285A, SER288A, SER292A, SER294A, SER294E, SER296A, SER296E, SER298A, SER298E, SER302E, SER304A, SER304E, SER339E, SER347E, SER350E, SER365E, SER40E, THR129A, THR136A, THR136E, THR154A, THR203A, THR212A, THR216A, THR216E, THR266A, THR270A, THR280A, THR301E, THR337E, THR340E, THR343E, THR348E, THR359E, THR44E, TRP169A, TRP261A, TRP261E, TYR123A, TYR123E, TYR151E, TYR205A, TYR231A, TYR234A, TYR242A, TYR276A, TYR291A, TYR356E, TYR364E, TYR371E, TYR463E, TYR49E, TYR70A, VAL115E, VAL139A, VAL143A, VAL143E, VAL147E, VAL149E, VAL201A, VAL21A, VAL220A, VAL220E, VAL22A, VAL271A, VAL290A, VAL300E, VAL352E, VAL368E, VAL45E, VAL471E, VAL52E
• B-C: ALA134B, ALA134C, ALA135B, ALA135C, ALA170C, ALA207C, ALA20C, ALA239C, ALA257C, ALA264C, ALA284C, ALA316C, ALA346B, ALA358B, ALA54B, ARG109B, ARG144B, ARG144C, ARG178C, ARG251C, ARG252C, ARG258B, ARG258C, ARG263C, ARG283C, ARG338B, ARG366B, ARG41B, ARG467B, ARG51B, ASN124C, ASN146B, ASN192C, ASN23C, ASN262C, ASN308B, ASN320C, ASN341B, ASN58B, ASP127B, ASP127C, ASP128B, ASP128C, ASP142B, ASP142C, ASP145B, ASP150B, ASP184C, ASP202C, ASP209C, ASP215B, ASP215C, ASP223B, ASP233C, ASP240C, ASP269C, ASP26C, ASP303B, ASP357B, ASP372B, ASP459B, ASP461B, ASP47B, CYS185C, CYS218B, CYS218C, CYS225B, CYS229C, CYS289C, CYS345B, GLN111B, GLN153B, GLN153C, GLN155C, GLN182C, GLN214B, GLN214C, GLN226B, GLN236C, GLN254B, GLN254C, GLN273C, GLN305B, GLN317C, GLN349B, GLN355B, GLN363B, GLN374B, GLN462B, GLN60B, GLU106B, GLU130B, GLU130C, GLU141B, GLU141C, GLU167C, GLU189C, GLU219C, GLU253C, GLU369B, GLU370B, GLY108B, GLY110B, GLY114B, GLY116B, GLY119B, GLY166C, GLY183C, GLY204C, GLY206C, GLY243C, GLY265C, GLY268C, GLY279C, GLY281C, GLY287C, GLY297B, GLY297C, GLY318C, GLY354B, GLY46B, GLY55B, GLY56B, GLY57B, HIS120B, HIS133B, HIS133C, HIS168C, HIS259B, HIS259C, HIS314C, HIS319C, HIS367B, ILE107B, ILE165C, ILE224B, ILE277C, ILE299B, ILE299C, ILE344B, ILE62B, LEU113B, LEU117B, LEU126B, LEU126C, LEU180C, LEU188C, LEU190C, LEU213C, LEU222B, LEU235C, LEU255C, LEU275C, LEU306C, LEU342B, LEU373B, LEU42B, LEU43B, LEU460B, LEU465B, LEU470B, LYS125B, LYS125C, LYS152C, LYS171C, LYS191C, LYS217B, LYS217C, LYS230C, LYS278C, LYS309B, LYS315C, LYS360B, LYS362B, LYS468B, LYS59B, LYS64B, MET208C, MET237C, MET246C, MET267C, MET282C, PHE122B, PHE122C, PHE210C, PHE247C, PHE256B, PHE256C, PHE260B, PHE260C, PHE307B, PHE361B, PHE50B, PRO112B, PRO121B, PRO179C, PRO186C, PRO187C, PRO221B, PRO232C, PRO241C, PRO272C, PRO286C, PRO293C, PRO295B, PRO295C, PRO351B, PRO353B, PRO464B, PRO48B, PRO53B, SER118B, SER131C, SER132B, SER132C, SER137B, SER140B, SER140C, SER148B, SER175C, SER177C, SER181C, SER227B, SER238C, SER274C, SER285C, SER288C, SER292C, SER294B, SER294C, SER296B, SER296C, SER298B, SER298C, SER302B, SER304B, SER304C, SER339B, SER347B, SER350B, SER365B, SER40B, THR129C, THR136B, THR136C, THR154C, THR203C, THR212C, THR216B, THR216C, THR266C, THR270C, THR280C, THR301B, THR337B, THR340B, THR343B, THR348B, THR359B, THR44B, TRP169C, TRP261B, TRP261C, TYR123B, TYR123C, TYR151B, TYR205C, TYR231C, TYR234C, TYR242C, TYR276C, TYR291C, TYR356B, TYR364B, TYR371B, TYR391C, TYR463B, TYR49B, TYR70C, VAL115B, VAL139C, VAL143B, VAL143C, VAL147B, VAL149B, VAL201C, VAL21C, VAL220B, VAL220C, VAL22C, VAL271C, VAL290C, VAL300B, VAL352B, VAL368B, VAL45B, VAL471B, VAL52B
• B-D: ALA284D, ARG283D, ASP357B, GLN273D, GLN355B, GLY279D, GLY354B, ILE277D, LYS278D, PHE361B, PRO353B, THR280D, TYR276D, TYR356B, VAL352B
• B-E: ALA284B, ARG283B, ASP357E, GLN273B, GLN355E, GLY279B, GLY281B, GLY354E, ILE277B, LYS278B, PHE361E, PRO353E, THR280B, TYR276B, TYR356E, VAL352E
• B-H: ARG30B, GLN355H, ILE33B, SER32B, THR31B
• B-I: ASN138I, ASP142I, ASP87B, GLU141I, ILE33B, ILE90B, PRO86B, SER140I, SER32B, SER89B, VAL143I
• B-J: ALA135J, ALA284J, ARG283J, ARG30B, ASN138J, ASN92B, ASP87B, GLN96B, GLU141J, GLU94B, GLY279J, GLY281J, ILE33B, ILE90B, LEU98B, MET282J, PRO93B, SER140J, SER285J, SER32B, SER89B, THR280J, THR29B, THR31B, THR381B, THR88B, THR95B, TYR91B, VAL139J
• C-D: ALA134C, ALA134D, ALA135C, ALA135D, ALA170D, ALA207D, ALA20D, ALA239D, ALA257D, ALA264D, ALA284D, ALA316D, ALA346C, ALA358C, ALA54C, ARG109C, ARG144C, ARG144D, ARG178D, ARG251D, ARG252D, ARG258C, ARG258D, ARG263D, ARG283D, ARG338C, ARG366C, ARG41C, ARG467C, ARG51C, ASN124D, ASN146C, ASN192D, ASN23D, ASN262D, ASN308C, ASN320D, ASN341C, ASN58C, ASP127C, ASP127D, ASP128C, ASP128D, ASP142C, ASP142D, ASP145C, ASP150C, ASP184D, ASP202D, ASP209D, ASP215C, ASP215D, ASP223C, ASP233D, ASP240D, ASP269D, ASP26D, ASP303C, ASP357C, ASP372C, ASP459C, ASP461C, ASP47C, CYS185D, CYS218C, CYS218D, CYS225C, CYS229D, CYS289D, CYS345C, GLN111C, GLN153C, GLN153D, GLN155D, GLN182D, GLN214C, GLN214D, GLN226C, GLN236D, GLN254C, GLN254D, GLN273D, GLN305C, GLN317D, GLN349C, GLN355C, GLN363C, GLN374C, GLN462C, GLN60C, GLU106C, GLU130C, GLU130D, GLU141C, GLU141D, GLU167D, GLU189D, GLU219D, GLU253D, GLU369C, GLU370C, GLY108C, GLY110C, GLY114C, GLY116C, GLY119C, GLY183D, GLY204D, GLY206D, GLY243D, GLY265D, GLY268D, GLY279D, GLY281D, GLY287D, GLY297C, GLY297D, GLY318D, GLY354C, GLY46C, GLY55C, GLY56C, GLY57C, HIS120C, HIS133C, HIS133D, HIS168D, HIS259C, HIS259D, HIS314D, HIS319D, HIS367C, ILE107C, ILE165D, ILE224C, ILE277D, ILE299C, ILE299D, ILE344C, ILE62C, LEU113C, LEU117C, LEU126C, LEU126D, LEU180D, LEU188D, LEU190D, LEU213D, LEU222C, LEU235D, LEU255D, LEU275D, LEU306D, LEU342C, LEU373C, LEU42C, LEU43C, LEU460C, LEU465C, LEU470C, LYS125C, LYS125D, LYS152D, LYS171D, LYS191D, LYS217C, LYS217D, LYS230D, LYS278D, LYS309C, LYS315D, LYS360C, LYS362C, LYS468C, LYS59C, LYS64C, MET208D, MET237D, MET246D, MET267D, MET282D, PHE122C, PHE122D, PHE210D, PHE256C, PHE256D, PHE260C, PHE260D, PHE307C, PHE361C, PHE50C, PRO112C, PRO121C, PRO179D, PRO186D, PRO187D, PRO221C, PRO232D, PRO241D, PRO272D, PRO286D, PRO293D, PRO295C, PRO295D, PRO351C, PRO353C, PRO464C, PRO48C, PRO53C, SER118C, SER131D, SER132C, SER132D, SER137C, SER140C, SER140D, SER148C, SER175D, SER177D, SER181D, SER227C, SER238D, SER274D, SER285D, SER288D, SER292D, SER294C, SER294D, SER296C, SER296D, SER298C, SER298D, SER302C, SER304C, SER304D, SER339C, SER347C, SER350C, SER365C, SER40C, THR129D, THR136C, THR136D, THR154D, THR203D, THR212D, THR216C, THR216D, THR266D, THR270D, THR280D, THR301C, THR337C, THR340C, THR343C, THR348C, THR359C, THR44C, TRP169D, TRP261C, TRP261D, TYR123C, TYR123D, TYR205D, TYR231D, TYR234D, TYR242D, TYR276D, TYR291D, TYR356C, TYR364C, TYR371C, TYR391D, TYR463C, TYR49C, TYR70D, VAL115C, VAL139D, VAL143C, VAL143D, VAL147C, VAL149C, VAL201D, VAL21D, VAL220C, VAL220D, VAL22D, VAL271D, VAL290D, VAL300C, VAL352C, VAL368C, VAL45C, VAL471C, VAL52C
• C-E: ALA284E, ARG283E, ASP357C, GLN273E, GLN355C, GLY279E, GLY281E, GLY354C, ILE277E, LYS278E, PHE361C, PRO353C, THR280E, TYR276E, TYR356C, VAL352C
• C-G: ALA386C, ASP387C, GLN355G, GLY354G, MET389C, SER390C, THR385C, TYR356G, VAL388C
• C-I: ALA284I, ALA386C, ASP387C, GLY279I, GLY281I, LYS278I, SER390C, THR280I, THR385C, VAL388C
• D-E: ALA134D, ALA134E, ALA135D, ALA135E, ALA170E, ALA207E, ALA20E, ALA239E, ALA257E, ALA264E, ALA284E, ALA316E, ALA346D, ALA358D, ALA54D, ARG109D, ARG144D, ARG144E, ARG178E, ARG251E, ARG252E, ARG258D, ARG258E, ARG263E, ARG283E, ARG338D, ARG366D, ARG41D, ARG467D, ARG51D, ASN124E, ASN146D, ASN192E, ASN23E, ASN262E, ASN308D, ASN320E, ASN341D, ASN58D, ASP127D, ASP127E, ASP128D, ASP128E, ASP142D, ASP142E, ASP145D, ASP150D, ASP184E, ASP202E, ASP209E, ASP215D, ASP215E, ASP223D, ASP233E, ASP240E, ASP269E, ASP26E, ASP303D, ASP357D, ASP372D, ASP459D, ASP461D, ASP47D, CYS185E, CYS218D, CYS218E, CYS225D, CYS229E, CYS289E, CYS345D, GLN111D, GLN153D, GLN153E, GLN182E, GLN214D, GLN214E, GLN226D, GLN226E, GLN236E, GLN254E, GLN273E, GLN305D, GLN317E, GLN349D, GLN355D, GLN363D, GLN374D, GLN462D, GLN60D, GLU106D, GLU130E, GLU141D, GLU141E, GLU167E, GLU189E, GLU219E, GLU253E, GLU369D, GLU370D, GLY108D, GLY110D, GLY114D, GLY116D, GLY119D, GLY183E, GLY204E, GLY206E, GLY243E, GLY265E, GLY268E, GLY279E, GLY281E, GLY287E, GLY297D, GLY297E, GLY318E, GLY354D, GLY46D, GLY55D, GLY56D, GLY57D, HIS120D, HIS133D, HIS133E, HIS168E, HIS259D, HIS259E, HIS314E, HIS319E, HIS367D, ILE107D, ILE165E, ILE224D, ILE277E, ILE299D, ILE299E, ILE344D, ILE62D, LEU113D, LEU117D, LEU126D, LEU126E, LEU180E, LEU188E, LEU190E, LEU213E, LEU222D, LEU235E, LEU255E, LEU275E, LEU306E, LEU342D, LEU373D, LEU42D, LEU43D, LEU460D, LEU465D, LEU470D, LYS125D, LYS125E, LYS152E, LYS171E, LYS191E, LYS217D, LYS217E, LYS230E, LYS278E, LYS309D, LYS315E, LYS360D, LYS362D, LYS468D, LYS59D, LYS64D, MET208E, MET237E, MET267E, MET282E, PHE122D, PHE122E, PHE210E, PHE256D, PHE256E, PHE260D, PHE260E, PHE307D, PHE361D, PHE50D, PRO112D, PRO121D, PRO179E, PRO186E, PRO187E, PRO221D, PRO232E, PRO241E, PRO272E, PRO286E, PRO293E, PRO295D, PRO295E, PRO351D, PRO353D, PRO464D, PRO48D, PRO53D, SER118D, SER131E, SER132D, SER132E, SER137D, SER140E, SER148D, SER175E, SER177E, SER181E, SER227D, SER238E, SER274E, SER285E, SER288E, SER292E, SER294D, SER294E, SER296D, SER296E, SER298D, SER298E, SER302D, SER304D, SER304E, SER339D, SER347D, SER350D, SER365D, SER40D, THR129E, THR136D, THR136E, THR154E, THR203E, THR212E, THR216D, THR216E, THR266E, THR270E, THR280E, THR301D, THR337D, THR340D, THR343D, THR348D, THR359D, THR44D, TRP169E, TRP261D, TRP261E, TYR123D, TYR123E, TYR151D, TYR205E, TYR231E, TYR234E, TYR242E, TYR276E, TYR291E, TYR356D, TYR364D, TYR371D, TYR463D, TYR49D, TYR70E, VAL115D, VAL139E, VAL143D, VAL143E, VAL147D, VAL149D, VAL201E, VAL21E, VAL220D, VAL220E, VAL22E, VAL271E, VAL290E, VAL300D, VAL352D, VAL368D, VAL45D, VAL471D, VAL52D
• F-G: ALA134F, ALA134G, ALA135F, ALA135G, ALA170G, ALA207G, ALA20G, ALA239G, ALA257G, ALA264G, ALA284G, ALA316G, ALA346F, ALA358F, ALA54F, ARG109F, ARG144F, ARG144G, ARG178G, ARG251G, ARG252G, ARG258F, ARG258G, ARG263G, ARG283G, ARG338F, ARG366F, ARG41F, ARG467F, ARG51F, ASN124G, ASN138G, ASN146F, ASN192G, ASN23G, ASN262G, ASN308F, ASN320G, ASN341F, ASN58F, ASP127F, ASP127G, ASP128F, ASP128G, ASP142F, ASP142G, ASP145F, ASP150F, ASP184G, ASP202G, ASP209G, ASP215F, ASP215G, ASP223F, ASP233G, ASP240G, ASP269G, ASP26G, ASP303F, ASP357F, ASP372F, ASP459F, ASP461F, ASP47F, CYS185G, CYS218F, CYS218G, CYS225F, CYS229G, CYS289G, CYS345F, GLN111F, GLN153F, GLN153G, GLN155G, GLN182G, GLN214F, GLN214G, GLN226F, GLN236G, GLN254F, GLN254G, GLN273G, GLN305F, GLN317G, GLN349F, GLN355F, GLN363F, GLN374F, GLN462F, GLN60F, GLU106F, GLU130G, GLU141F, GLU141G, GLU167G, GLU189G, GLU219G, GLU253G, GLU369F, GLU370F, GLY108F, GLY110F, GLY114F, GLY116F, GLY119F, GLY166G, GLY183G, GLY204G, GLY206G, GLY243G, GLY265G, GLY268G, GLY279G, GLY281G, GLY287G, GLY297F, GLY297G, GLY318G, GLY354F, GLY46F, GLY55F, GLY56F, GLY57F, HIS120F, HIS133F, HIS133G, HIS168G, HIS259F, HIS259G, HIS314G, HIS319G, HIS367F, ILE107F, ILE165G, ILE224F, ILE277G, ILE299F, ILE299G, ILE344F, ILE62F, LEU113F, LEU117F, LEU126F, LEU126G, LEU180G, LEU188G, LEU190G, LEU213G, LEU222F, LEU235G, LEU255G, LEU275G, LEU306G, LEU342F, LEU373F, LEU42F, LEU43F, LEU460F, LEU465F, LEU470F, LYS125F, LYS125G, LYS152G, LYS171G, LYS191G, LYS217F, LYS217G, LYS230G, LYS278G, LYS309F, LYS315G, LYS360F, LYS362F, LYS468F, LYS59F, LYS64F, MET208G, MET237G, MET246G, MET267G, MET282G, PHE122F, PHE122G, PHE210G, PHE256F, PHE256G, PHE260F, PHE260G, PHE307F, PHE361F, PHE50F, PRO112F, PRO121F, PRO179G, PRO186G, PRO187G, PRO221F, PRO232G, PRO241G, PRO272G, PRO286G, PRO293G, PRO295F, PRO295G, PRO351F, PRO353F, PRO464F, PRO48F, PRO53F, SER118F, SER131G, SER132F, SER132G, SER137F, SER140F, SER140G, SER148F, SER175G, SER177G, SER181G, SER211F, SER227F, SER238G, SER274G, SER285G, SER288G, SER292G, SER294F, SER294G, SER296F, SER296G, SER298F, SER298G, SER302F, SER304F, SER304G, SER339F, SER347F, SER350F, SER365F, SER40F, THR129G, THR136F, THR136G, THR154G, THR203G, THR212G, THR216F, THR216G, THR266G, THR270G, THR280G, THR301F, THR337F, THR340F, THR343F, THR348F, THR359F, THR44F, TRP169G, TRP261F, TRP261G, TYR123F, TYR123G, TYR151F, TYR205G, TYR231G, TYR234G, TYR242G, TYR276G, TYR291G, TYR356F, TYR364F, TYR371F, TYR391G, TYR463F, TYR49F, TYR70G, VAL115F, VAL139G, VAL143F, VAL143G, VAL147F, VAL149F, VAL201G, VAL21G, VAL220F, VAL220G, VAL22G, VAL271G, VAL290G, VAL300F, VAL352F, VAL368F, VAL45F, VAL471F, VAL52F
• F-H: ALA284H, ARG283H, ASP357F, GLN273H, GLN355F, GLY279H, GLY281H, GLY354F, ILE277H, LYS278H, PHE361F, PRO353F, SER347F, THR280H, TYR276H, TYR356F, VAL352F
• F-I: ALA284F, ARG283F, ASP357I, GLN273F, GLN355I, GLY279F, GLY281F, GLY354I, ILE277F, LYS278F, PHE361I, PRO353I, THR280F, TYR276F, TYR356I, VAL352I
• F-J: ALA134F, ALA134J, ALA135F, ALA135J, ALA170F, ALA207F, ALA20F, ALA239F, ALA257F, ALA264F, ALA284F, ALA316F, ALA346J, ALA358J, ALA54J, ARG109J, ARG144F, ARG144J, ARG178F, ARG251F, ARG252F, ARG258F, ARG258J, ARG263F, ARG283F, ARG338J, ARG366J, ARG41J, ARG467J, ARG51J, ASN124F, ASN146J, ASN192F, ASN23F, ASN262F, ASN308J, ASN320F, ASN341J, ASN58J, ASP127F, ASP127J, ASP128F, ASP128J, ASP142F, ASP142J, ASP145F, ASP145J, ASP150J, ASP184F, ASP202F, ASP209F, ASP215F, ASP215J, ASP223J, ASP233F, ASP240F, ASP269F, ASP303J, ASP357J, ASP372J, ASP459J, ASP461J, ASP47J, CYS185F, CYS218F, CYS218J, CYS225J, CYS229F, CYS289F, CYS345J, GLN111J, GLN153F, GLN153J, GLN155F, GLN182F, GLN214F, GLN214J, GLN226F, GLN226J, GLN236F, GLN254F, GLN254J, GLN273F, GLN305J, GLN317F, GLN349J, GLN355J, GLN363J, GLN374J, GLN462J, GLN60J, GLU106J, GLU130F, GLU141F, GLU141J, GLU167F, GLU189F, GLU219F, GLU253F, GLU369J, GLU370J, GLY108J, GLY110J, GLY114J, GLY116J, GLY119J, GLY183F, GLY204F, GLY206F, GLY243F, GLY265F, GLY268F, GLY279F, GLY281F, GLY287F, GLY297F, GLY297J, GLY318F, GLY354J, GLY46J, GLY55J, GLY56J, GLY57J, HIS120J, HIS133F, HIS133J, HIS168F, HIS259F, HIS259J, HIS319F, HIS367J, ILE107J, ILE224J, ILE277F, ILE299F, ILE299J, ILE344J, ILE62J, LEU113J, LEU117J, LEU126F, LEU126J, LEU180F, LEU188F, LEU190F, LEU213F, LEU222J, LEU235F, LEU255F, LEU275F, LEU342J, LEU42J, LEU43J, LEU460J, LEU465J, LYS125F, LYS125J, LYS152F, LYS171F, LYS191F, LYS217F, LYS217J, LYS230F, LYS278F, LYS309J, LYS315F, LYS360J, LYS362J, LYS468J, LYS59J, LYS64J, MET208F, MET237F, MET267F, MET282F, PHE122F, PHE122J, PHE210F, PHE256F, PHE256J, PHE260F, PHE260J, PHE307J, PHE361J, PHE50J, PRO112J, PRO121J, PRO179F, PRO186F, PRO187F, PRO221J, PRO232F, PRO241F, PRO272F, PRO286F, PRO293F, PRO295F, PRO295J, PRO351J, PRO353J, PRO464J, PRO48J, PRO53J, SER118J, SER131F, SER132F, SER132J, SER137J, SER140F, SER148J, SER175F, SER177F, SER181F, SER211J, SER227J, SER238F, SER274F, SER285F, SER288F, SER292F, SER294F, SER294J, SER296F, SER296J, SER298F, SER298J, SER302J, SER304F, SER304J, SER339J, SER347J, SER350J, SER365J, SER40J, THR129F, THR136F, THR136J, THR154F, THR203F, THR212F, THR216F, THR216J, THR266F, THR270F, THR280F, THR301J, THR337J, THR340J, THR343J, THR348J, THR359J, THR44J, TRP169F, TRP261F, TRP261J, TYR123F, TYR123J, TYR151J, TYR205F, TYR231F, TYR234F, TYR242F, TYR276F, TYR291F, TYR356J, TYR364J, TYR371J, TYR463J, TYR49J, VAL115J, VAL139F, VAL143F, VAL143J, VAL147J, VAL149J, VAL21F, VAL220F, VAL220J, VAL22F, VAL271F, VAL290F, VAL300J, VAL352J, VAL368J, VAL45J, VAL471J, VAL52J
• F-M: ARG30F, ASP357M, GLN355M, ILE90F, SER32F, SER89F, THR29F, THR31F
• F-N: ASN138N, ASP142N, ASP87F, GLU141N, ILE33F, ILE90F, LEU458F, PRO86F, SER140N, SER32F, SER89F, THR31F, VAL143N
• F-O: ALA135O, ALA284O, ARG283O, ASN138O, ASN92F, ASP87F, GLN96F, GLU94F, GLY279O, GLY281O, ILE33F, ILE90F, LEU98F, MET282O, PRO93F, SER140O, SER285O, SER32F, SER89F, THR280O, THR29F, THR31F, THR381F, THR88F, THR95F, TYR91F, VAL139O
• G-H: ALA134G, ALA134H, ALA135G, ALA135H, ALA170H, ALA207H, ALA20H, ALA239H, ALA257H, ALA264H, ALA284H, ALA316H, ALA346G, ALA358G, ALA54G, ARG109G, ARG144G, ARG144H, ARG178H, ARG251H, ARG252H, ARG258G, ARG258H, ARG263H, ARG283H, ARG338G, ARG366G, ARG41G, ARG467G, ARG51G, ASN124H, ASN146G, ASN192H, ASN23H, ASN262H, ASN308G, ASN320H, ASN341G, ASN58G, ASP127G, ASP127H, ASP128G, ASP128H, ASP142G, ASP142H, ASP145G, ASP150G, ASP184H, ASP202H, ASP209H, ASP215G, ASP215H, ASP223G, ASP233H, ASP240H, ASP269H, ASP26H, ASP303G, ASP357G, ASP372G, ASP459G, ASP461G, ASP47G, CYS185H, CYS218G, CYS218H, CYS225G, CYS229H, CYS289H, CYS345G, GLN111G, GLN153G, GLN153H, GLN155H, GLN182H, GLN214G, GLN214H, GLN226G, GLN226H, GLN236H, GLN254H, GLN273H, GLN305G, GLN317H, GLN349G, GLN355G, GLN363G, GLN374G, GLN462G, GLN60G, GLU106G, GLU130H, GLU141G, GLU141H, GLU167H, GLU189H, GLU219H, GLU253H, GLU369G, GLU370G, GLY108G, GLY110G, GLY114G, GLY116G, GLY119G, GLY183H, GLY204H, GLY206H, GLY243H, GLY265H, GLY268H, GLY279H, GLY281H, GLY287H, GLY297G, GLY297H, GLY318H, GLY354G, GLY46G, GLY55G, GLY56G, GLY57G, HIS120G, HIS133G, HIS133H, HIS168H, HIS259G, HIS259H, HIS314H, HIS319H, HIS367G, ILE107G, ILE165H, ILE224G, ILE277H, ILE299G, ILE299H, ILE344G, ILE62G, LEU113G, LEU117G, LEU126G, LEU126H, LEU180H, LEU188H, LEU190H, LEU213H, LEU222G, LEU235H, LEU255H, LEU275H, LEU306H, LEU342G, LEU373G, LEU42G, LEU43G, LEU460G, LEU465G, LEU470G, LYS125G, LYS125H, LYS152H, LYS171H, LYS191H, LYS217G, LYS217H, LYS230H, LYS278H, LYS309G, LYS315H, LYS360G, LYS362G, LYS468G, LYS59G, LYS64G, MET208H, MET237H, MET267H, MET282H, PHE122G, PHE122H, PHE210H, PHE256G, PHE256H, PHE260G, PHE260H, PHE307G, PHE361G, PHE50G, PRO112G, PRO121G, PRO179H, PRO186H, PRO187H, PRO221G, PRO232H, PRO241H, PRO272H, PRO286H, PRO293H, PRO295G, PRO295H, PRO351G, PRO353G, PRO464G, PRO48G, PRO53G, SER118G, SER131H, SER132G, SER132H, SER137G, SER140G, SER140H, SER148G, SER175H, SER177H, SER181H, SER227G, SER238H, SER274H, SER285H, SER288H, SER292H, SER294G, SER294H, SER296G, SER296H, SER298G, SER298H, SER302G, SER304G, SER304H, SER339G, SER347G, SER350G, SER365G, SER40G, THR129H, THR136G, THR136H, THR154H, THR203H, THR212H, THR216G, THR216H, THR266H, THR270H, THR280H, THR301G, THR337G, THR340G, THR343G, THR348G, THR359G, THR44G, TRP169H, TRP261G, TRP261H, TYR123G, TYR123H, TYR151G, TYR205H, TYR231H, TYR234H, TYR242H, TYR276H, TYR291H, TYR356G, TYR364G, TYR371G, TYR463G, TYR49G, TYR70H, VAL115G, VAL139H, VAL143G, VAL143H, VAL147G, VAL149G, VAL201H, VAL21H, VAL220G, VAL220H, VAL22H, VAL271H, VAL290H, VAL300G, VAL352G, VAL368G, VAL45G, VAL471G, VAL52G
• G-I: ALA284I, ARG283I, ASP357G, GLN355G, GLY279I, GLY281I, GLY354G, ILE277I, LYS278I, PHE361G, PRO353G, THR280I, TYR276I, TYR356G, VAL352G
• G-J: ALA284G, ARG283G, ASP357J, GLN273G, GLN355J, GLY279G, GLY281G, GLY354J, ILE277G, LYS278G, PHE361J, PRO353J, THR280G, TYR276G, TYR356J, VAL352J
• G-L: ALA386G, ASP387G, GLN355L, GLY354L, MET389G, PRO353L, SER390G, THR385G, TYR356L, TYR391G, VAL388G
• G-M: ALA386G, GLU141M
• G-N: ALA284N, ALA386G, ASP387G, GLN273N, GLY279N, GLY281N, ILE277N, LYS278N, SER390G, THR280N, THR385G, TYR391G, VAL388G
• H-I: ALA134H, ALA134I, ALA135H, ALA135I, ALA170I, ALA207I, ALA20I, ALA239I, ALA257I, ALA264I, ALA284I, ALA316I, ALA346H, ALA358H, ARG109H, ARG144H, ARG144I, ARG178I, ARG251I, ARG252I, ARG258H, ARG258I, ARG263I, ARG283I, ARG338H, ARG366H, ARG41H, ARG467H, ARG51H, ASN124I, ASN138I, ASN146H, ASN192I, ASN23I, ASN262I, ASN308H, ASN320I, ASN341H, ASN58H, ASP127H, ASP127I, ASP128H, ASP128I, ASP142H, ASP142I, ASP145H, ASP150H, ASP184I, ASP202I, ASP209I, ASP215H, ASP215I, ASP223H, ASP233I, ASP240I, ASP269I, ASP26I, ASP303H, ASP357H, ASP372H, ASP459H, ASP461H, ASP47H, CYS185I, CYS218H, CYS218I, CYS225H, CYS229I, CYS289I, CYS345H, GLN111H, GLN153H, GLN153I, GLN182I, GLN214H, GLN214I, GLN226H, GLN236I, GLN254H, GLN254I, GLN273I, GLN305H, GLN317I, GLN349H, GLN355H, GLN363H, GLN374H, GLN462H, GLN60H, GLU106H, GLU130I, GLU141H, GLU141I, GLU167I, GLU189I, GLU219I, GLU253I, GLU369H, GLU370H, GLY108H, GLY110H, GLY114H, GLY116H, GLY119H, GLY183I, GLY204I, GLY206I, GLY243I, GLY265I, GLY268I, GLY279I, GLY281I, GLY287I, GLY297H, GLY297I, GLY318I, GLY354H, GLY46H, GLY55H, GLY56H, GLY57H, HIS120H, HIS133H, HIS133I, HIS168I, HIS259H, HIS259I, HIS314I, HIS319I, HIS367H, ILE107H, ILE165I, ILE224H, ILE277I, ILE299H, ILE299I, ILE344H, ILE62H, LEU113H, LEU117H, LEU126H, LEU126I, LEU180I, LEU188I, LEU190I, LEU213I, LEU222H, LEU235I, LEU255I, LEU275I, LEU306I, LEU342H, LEU373H, LEU42H, LEU43H, LEU460H, LEU465H, LEU470H, LYS125H, LYS125I, LYS152I, LYS171I, LYS191I, LYS217H, LYS217I, LYS230I, LYS278I, LYS309H, LYS315I, LYS360H, LYS362H, LYS468H, LYS59H, LYS64H, MET208I, MET237I, MET267I, MET282I, PHE122H, PHE122I, PHE210I, PHE256H, PHE256I, PHE260H, PHE260I, PHE307H, PHE361H, PHE50H, PRO112H, PRO121H, PRO179I, PRO186I, PRO187I, PRO221H, PRO232I, PRO241I, PRO272I, PRO286I, PRO293I, PRO295H, PRO295I, PRO351H, PRO353H, PRO464H, PRO48H, PRO53H, SER118H, SER131I, SER132H, SER132I, SER137H, SER140I, SER148H, SER175I, SER177I, SER181I, SER211H, SER227H, SER238I, SER274I, SER285I, SER288I, SER292I, SER294H, SER294I, SER296H, SER296I, SER298H, SER298I, SER302H, SER304H, SER304I, SER339H, SER347H, SER350H, SER365H, SER40H, THR129I, THR136H, THR136I, THR154I, THR203I, THR212I, THR216H, THR216I, THR266I, THR270I, THR280I, THR301H, THR337H, THR340H, THR343H, THR348H, THR359H, THR44H, TRP169I, TRP261H, TRP261I, TYR123H, TYR123I, TYR151H, TYR205I, TYR231I, TYR234I, TYR242I, TYR276I, TYR291I, TYR356H, TYR364H, TYR371H, TYR463H, TYR49H, TYR70I, VAL115H, VAL139I, VAL143H, VAL143I, VAL147H, VAL149H, VAL21I, VAL220H, VAL220I, VAL22I, VAL271I, VAL290I, VAL300H, VAL352H, VAL368H, VAL45H, VAL471H, VAL52H
• H-J: ALA284J, ARG283J, ASP357H, GLN355H, GLY279J, GLY281J, GLY354H, ILE277J, LYS278J, PHE361H, PRO353H, THR280J, TYR276J, TYR356H, VAL352H
• I-J: ALA134I, ALA134J, ALA135I, ALA135J, ALA170J, ALA207J, ALA20J, ALA239J, ALA257J, ALA264J, ALA284J, ALA316J, ALA346I, ALA358I, ALA54I, ARG109I, ARG144I, ARG144J, ARG178J, ARG251J, ARG252J, ARG258I, ARG258J, ARG263J, ARG283J, ARG338I, ARG366I, ARG41I, ARG467I, ARG51I, ASN124J, ASN146I, ASN192J, ASN23J, ASN262J, ASN308I, ASN320J, ASN341I, ASN58I, ASP127I, ASP127J, ASP128I, ASP128J, ASP142I, ASP142J, ASP145I, ASP150I, ASP184J, ASP202J, ASP209J, ASP215I, ASP215J, ASP223I, ASP233J, ASP240J, ASP269J, ASP26J, ASP303I, ASP357I, ASP372I, ASP459I, ASP461I, ASP47I, CYS185J, CYS218I, CYS218J, CYS225I, CYS229J, CYS289J, CYS345I, GLN111I, GLN153I, GLN153J, GLN155J, GLN182J, GLN214I, GLN214J, GLN226I, GLN226J, GLN236J, GLN254I, GLN254J, GLN273J, GLN305I, GLN317J, GLN349I, GLN355I, GLN363I, GLN374I, GLN462I, GLN60I, GLU106I, GLU130J, GLU141I, GLU141J, GLU167J, GLU189J, GLU219J, GLU253J, GLU369I, GLU370I, GLY108I, GLY110I, GLY114I, GLY116I, GLY119I, GLY183J, GLY204J, GLY206J, GLY243J, GLY265J, GLY268J, GLY279J, GLY281J, GLY287J, GLY297I, GLY297J, GLY318J, GLY354I, GLY46I, GLY55I, GLY56I, GLY57I, HIS120I, HIS133I, HIS133J, HIS168J, HIS259I, HIS259J, HIS314J, HIS319J, HIS367I, ILE107I, ILE165J, ILE224I, ILE277J, ILE299I, ILE299J, ILE344I, ILE62I, LEU113I, LEU117I, LEU126I, LEU126J, LEU180J, LEU188J, LEU190J, LEU213J, LEU222I, LEU235J, LEU255J, LEU275J, LEU306J, LEU342I, LEU373I, LEU42I, LEU43I, LEU460I, LEU465I, LEU470I, LYS125I, LYS125J, LYS152J, LYS171J, LYS191J, LYS217I, LYS217J, LYS230J, LYS278J, LYS309I, LYS315J, LYS360I, LYS362I, LYS468I, LYS59I, LYS64I, MET208J, MET237J, MET267J, MET282J, PHE122I, PHE122J, PHE210J, PHE256I, PHE256J, PHE260I, PHE260J, PHE307I, PHE361I, PHE50I, PRO112I, PRO121I, PRO179J, PRO186J, PRO187J, PRO221I, PRO232J, PRO241J, PRO272J, PRO286J, PRO293J, PRO295I, PRO295J, PRO351I, PRO353I, PRO464I, PRO48I, PRO53I, SER118I, SER131J, SER132I, SER132J, SER137I, SER140J, SER148I, SER175J, SER177J, SER181J, SER227I, SER238J, SER274J, SER285J, SER288J, SER292J, SER294I, SER294J, SER296I, SER296J, SER298I, SER298J, SER302I, SER304I, SER304J, SER339I, SER347I, SER350I, SER365I, SER40I, THR129J, THR136I, THR136J, THR154J, THR203J, THR212J, THR216I, THR216J, THR266J, THR270J, THR280J, THR301I, THR337I, THR340I, THR343I, THR348I, THR359I, THR44I, TRP169J, TRP261I, TRP261J, TYR123I, TYR123J, TYR151I, TYR205J, TYR231J, TYR234J, TYR242J, TYR276J, TYR291J, TYR356I, TYR364I, TYR371I, TYR463I, TYR49I, TYR70J, VAL115I, VAL139J, VAL143I, VAL143J, VAL147I, VAL149I, VAL201J, VAL21J, VAL220I, VAL220J, VAL22J, VAL271J, VAL290J, VAL300I, VAL352I, VAL368I, VAL45I, VAL471I, VAL52I
• K-L: ALA134K, ALA134L, ALA135K, ALA135L, ALA170L, ALA207L, ALA20L, ALA239L, ALA257L, ALA264L, ALA284L, ALA316L, ALA346K, ALA358K, ALA54K, ARG109K, ARG144K, ARG144L, ARG178L, ARG251L, ARG252L, ARG258K, ARG258L, ARG263L, ARG283L, ARG338K, ARG366K, ARG41K, ARG467K, ARG51K, ASN124L, ASN146K, ASN192L, ASN23L, ASN262L, ASN308K, ASN320L, ASN341K, ASN58K, ASP127K, ASP127L, ASP128K, ASP128L, ASP142K, ASP142L, ASP145K, ASP150K, ASP184L, ASP202L, ASP209L, ASP215K, ASP215L, ASP223K, ASP233L, ASP240L, ASP269L, ASP26L, ASP303K, ASP357K, ASP372K, ASP459K, ASP461K, ASP47K, CYS185L, CYS218K, CYS218L, CYS225K, CYS229L, CYS289L, CYS345K, GLN111K, GLN153K, GLN153L, GLN155L, GLN182L, GLN214K, GLN214L, GLN226K, GLN226L, GLN236L, GLN254K, GLN254L, GLN273L, GLN305K, GLN317L, GLN349K, GLN355K, GLN363K, GLN374K, GLN462K, GLN60K, GLU106K, GLU130K, GLU130L, GLU141K, GLU141L, GLU167L, GLU189L, GLU219L, GLU253L, GLU369K, GLU370K, GLY108K, GLY110K, GLY114K, GLY116K, GLY119K, GLY183L, GLY204L, GLY206L, GLY243L, GLY265L, GLY268L, GLY279L, GLY281L, GLY287L, GLY297K, GLY297L, GLY318L, GLY354K, GLY46K, GLY55K, GLY56K, GLY57K, HIS120K, HIS133K, HIS133L, HIS168L, HIS259K, HIS259L, HIS314L, HIS319L, HIS367K, ILE107K, ILE165L, ILE224K, ILE277L, ILE299K, ILE299L, ILE344K, ILE62K, LEU113K, LEU117K, LEU126K, LEU126L, LEU180L, LEU188L, LEU190L, LEU213L, LEU222K, LEU235L, LEU255L, LEU275L, LEU306L, LEU342K, LEU373K, LEU42K, LEU43K, LEU460K, LEU465K, LEU470K, LYS125K, LYS125L, LYS152L, LYS171L, LYS191L, LYS217K, LYS217L, LYS230L, LYS278L, LYS309K, LYS315L, LYS360K, LYS362K, LYS468K, LYS59K, LYS64K, MET208L, MET237L, MET267L, MET282L, PHE122K, PHE122L, PHE210L, PHE256K, PHE256L, PHE260K, PHE260L, PHE307K, PHE361K, PHE50K, PRO112K, PRO121K, PRO179L, PRO186L, PRO187L, PRO221K, PRO232L, PRO241L, PRO272L, PRO286L, PRO293L, PRO295K, PRO295L, PRO351K, PRO353K, PRO464K, PRO48K, PRO53K, SER118K, SER131L, SER132K, SER132L, SER137K, SER140K, SER140L, SER148K, SER175L, SER177L, SER181L, SER211K, SER227K, SER238L, SER274L, SER285L, SER288L, SER292L, SER294K, SER294L, SER296K, SER296L, SER298K, SER298L, SER302K, SER304K, SER304L, SER339K, SER347K, SER350K, SER365K, SER40K, THR129L, THR136K, THR136L, THR154L, THR203L, THR212L, THR216K, THR216L, THR266L, THR270L, THR280L, THR301K, THR337K, THR340K, THR343K, THR348K, THR359K, THR44K, TRP169L, TRP261K, TRP261L, TYR123K, TYR123L, TYR151K, TYR205L, TYR231L, TYR234L, TYR242L, TYR276L, TYR291L, TYR356K, TYR364K, TYR371K, TYR463K, TYR49K, TYR70L, VAL115K, VAL139L, VAL143K, VAL143L, VAL147K, VAL149K, VAL201L, VAL21L, VAL220K, VAL220L, VAL22L, VAL271L, VAL290L, VAL300K, VAL352K, VAL368K, VAL45K, VAL471K, VAL52K
• K-M: ALA284M, ARG283M, ASP357K, GLN273M, GLN355K, GLY279M, GLY281M, GLY354K, ILE277M, LYS278M, PHE361K, PRO353K, THR280M, TYR276M, TYR356K, VAL352K
• K-N: ALA284K, ARG283K, ASP357N, GLN273K, GLN355N, GLY279K, GLY281K, GLY354N, ILE277K, LYS278K, PHE361N, PRO353N, THR280K, TYR276K, TYR356N, VAL352N
• K-O: ALA134K, ALA134O, ALA135K, ALA135O, ALA170K, ALA207K, ALA20K, ALA239K, ALA257K, ALA264K, ALA284K, ALA316K, ALA346O, ALA358O, ALA54O, ARG109O, ARG144K, ARG144O, ARG178K, ARG251K, ARG252K, ARG258K, ARG258O, ARG263K, ARG283K, ARG338O, ARG366O, ARG41O, ARG467O, ARG51O, ASN124K, ASN146O, ASN192K, ASN23K, ASN262K, ASN308O, ASN320K, ASN341O, ASN58O, ASP127K, ASP127O, ASP128K, ASP128O, ASP142K, ASP142O, ASP145O, ASP150O, ASP184K, ASP202K, ASP209K, ASP215K, ASP215O, ASP223O, ASP233K, ASP240K, ASP269K, ASP26K, ASP303O, ASP357O, ASP372O, ASP459O, ASP461O, ASP47O, CYS185K, CYS218K, CYS218O, CYS225O, CYS229K, CYS289K, CYS345O, GLN111O, GLN153K, GLN153O, GLN155K, GLN182K, GLN214K, GLN226K, GLN226O, GLN236K, GLN254K, GLN273K, GLN305O, GLN317K, GLN349O, GLN355O, GLN363O, GLN374O, GLN462O, GLN60O, GLU106O, GLU130K, GLU141K, GLU141O, GLU167K, GLU189K, GLU219K, GLU253K, GLU369O, GLU370O, GLY108O, GLY110O, GLY114O, GLY116O, GLY119O, GLY183K, GLY204K, GLY206K, GLY243K, GLY265K, GLY268K, GLY279K, GLY287K, GLY297K, GLY297O, GLY318K, GLY354O, GLY46O, GLY55O, GLY56O, GLY57O, HIS120O, HIS133K, HIS133O, HIS168K, HIS259K, HIS259O, HIS314K, HIS319K, HIS367O, ILE107O, ILE165K, ILE224O, ILE277K, ILE299K, ILE299O, ILE344O, ILE62O, LEU113O, LEU117O, LEU126K, LEU126O, LEU180K, LEU188K, LEU190K, LEU213K, LEU222O, LEU235K, LEU255K, LEU275K, LEU306K, LEU342O, LEU373O, LEU42O, LEU43O, LEU460O, LEU465O, LEU470O, LYS125K, LYS125O, LYS152K, LYS171K, LYS191K, LYS217K, LYS217O, LYS230K, LYS278K, LYS309O, LYS315K, LYS360O, LYS362O, LYS468O, LYS59O, LYS64O, MET208K, MET237K, MET267K, MET282K, PHE122K, PHE122O, PHE210K, PHE256K, PHE256O, PHE260K, PHE260O, PHE307O, PHE361O, PHE50O, PRO112O, PRO121O, PRO179K, PRO186K, PRO187K, PRO221O, PRO232K, PRO241K, PRO272K, PRO286K, PRO293K, PRO295K, PRO295O, PRO351O, PRO353O, PRO464O, PRO48O, PRO53O, SER118O, SER131K, SER132K, SER132O, SER137O, SER140K, SER140O, SER148O, SER175K, SER177K, SER181K, SER227O, SER238K, SER274K, SER285K, SER288K, SER292K, SER294K, SER294O, SER296K, SER296O, SER298K, SER298O, SER302O, SER304K, SER304O, SER339O, SER347O, SER350O, SER365O, SER40O, THR129K, THR136K, THR136O, THR154K, THR203K, THR212K, THR216K, THR216O, THR266K, THR270K, THR280K, THR301O, THR337O, THR340O, THR343O, THR348O, THR359O, THR44O, TRP169K, TRP261K, TRP261O, TYR123K, TYR123O, TYR151O, TYR205K, TYR231K, TYR234K, TYR242K, TYR276K, TYR291K, TYR356O, TYR364O, TYR371O, TYR391K, TYR463O, TYR49O, TYR70K, VAL115O, VAL139K, VAL143K, VAL143O, VAL147O, VAL149O, VAL201K, VAL21K, VAL220K, VAL22K, VAL271K, VAL290K, VAL300O, VAL352O, VAL368O, VAL45O, VAL471O, VAL52O
• L-M: ALA134L, ALA134M, ALA135L, ALA135M, ALA170M, ALA207M, ALA20M, ALA239M, ALA257M, ALA264M, ALA284M, ALA316M, ALA346L, ALA358L, ALA54L, ARG109L, ARG144L, ARG144M, ARG178M, ARG251M, ARG252M, ARG258L, ARG258M, ARG263M, ARG283M, ARG338L, ARG366L, ARG41L, ARG467L, ARG51L, ASN124M, ASN146L, ASN192M, ASN23M, ASN262M, ASN308L, ASN320M, ASN341L, ASN58L, ASP127L, ASP127M, ASP128L, ASP128M, ASP142L, ASP142M, ASP145L, ASP150L, ASP184M, ASP202M, ASP209M, ASP215L, ASP215M, ASP223L, ASP233M, ASP240M, ASP269M, ASP26M, ASP303L, ASP357L, ASP372L, ASP459L, ASP461L, ASP47L, CYS185M, CYS218L, CYS218M, CYS225L, CYS229M, CYS289M, CYS345L, GLN111L, GLN153L, GLN153M, GLN155M, GLN182M, GLN214L, GLN214M, GLN226L, GLN226M, GLN236M, GLN254L, GLN254M, GLN273M, GLN305L, GLN317M, GLN349L, GLN355L, GLN363L, GLN374L, GLN462L, GLN60L, GLU106L, GLU130L, GLU130M, GLU141L, GLU141M, GLU167M, GLU189M, GLU219M, GLU253M, GLU369L, GLU370L, GLY108L, GLY110L, GLY114L, GLY116L, GLY119L, GLY183M, GLY204M, GLY206M, GLY243M, GLY265M, GLY268M, GLY279M, GLY281M, GLY287M, GLY297L, GLY297M, GLY318M, GLY354L, GLY46L, GLY55L, GLY56L, GLY57L, HIS120L, HIS133L, HIS133M, HIS168M, HIS259L, HIS259M, HIS314M, HIS319M, HIS367L, ILE107L, ILE165M, ILE224L, ILE277M, ILE299L, ILE299M, ILE344L, ILE62L, LEU113L, LEU117L, LEU126L, LEU126M, LEU180M, LEU188M, LEU190M, LEU213M, LEU222L, LEU235M, LEU255M, LEU275M, LEU306M, LEU342L, LEU373L, LEU42L, LEU43L, LEU460L, LEU465L, LEU470L, LYS125L, LYS125M, LYS152M, LYS171M, LYS191M, LYS217L, LYS217M, LYS230M, LYS278M, LYS309L, LYS315M, LYS360L, LYS362L, LYS468L, LYS59L, LYS64L, MET208M, MET237M, MET267M, MET282M, PHE122L, PHE122M, PHE210M, PHE256L, PHE256M, PHE260L, PHE260M, PHE307L, PHE361L, PHE50L, PRO112L, PRO121L, PRO179M, PRO186M, PRO187M, PRO221L, PRO232M, PRO241M, PRO272M, PRO286M, PRO293M, PRO295L, PRO295M, PRO351L, PRO353L, PRO464L, PRO48L, PRO53L, SER118L, SER131M, SER132L, SER132M, SER137L, SER140M, SER148L, SER175M, SER177M, SER181M, SER227L, SER238M, SER274M, SER285M, SER288M, SER292M, SER294L, SER294M, SER296L, SER296M, SER298L, SER298M, SER302L, SER304L, SER304M, SER339L, SER347L, SER350L, SER365L, SER40L, THR129M, THR136L, THR136M, THR154M, THR203M, THR212M, THR216L, THR216M, THR266M, THR270M, THR280M, THR301L, THR337L, THR340L, THR343L, THR348L, THR359L, THR44L, TRP169M, TRP261L, TRP261M, TYR123L, TYR123M, TYR205M, TYR231M, TYR234M, TYR242M, TYR276M, TYR291M, TYR356L, TYR364L, TYR371L, TYR463L, TYR49L, TYR70M, VAL115L, VAL139M, VAL143L, VAL143M, VAL147L, VAL149L, VAL21M, VAL220L, VAL220M, VAL22M, VAL271M, VAL290M, VAL300L, VAL352L, VAL368L, VAL45L, VAL471L, VAL52L
• L-N: ALA284N, ARG283N, ASP357L, GLN355L, GLY279N, GLY281N, GLY354L, ILE277N, LYS278N, PHE361L, PRO353L, THR280N, TYR276N, TYR356L, VAL352L
• L-O: ALA284L, ARG283L, ASP357O, GLN273L, GLN355O, GLY279L, GLY281L, GLY354O, ILE277L, LYS278L, LYS360O, PHE361O, PRO353O, THR280L, TYR276L, TYR356O, VAL352O
• M-N: ALA134M, ALA134N, ALA135M, ALA135N, ALA170N, ALA207N, ALA20N, ALA239N, ALA257N, ALA264N, ALA284N, ALA316N, ALA346M, ALA358M, ALA54M, ARG109M, ARG144M, ARG144N, ARG178N, ARG251N, ARG252N, ARG258M, ARG258N, ARG263N, ARG283N, ARG338M, ARG366M, ARG41M, ARG467M, ARG51M, ASN124N, ASN138N, ASN146M, ASN192N, ASN23N, ASN262N, ASN308M, ASN320N, ASN341M, ASN58M, ASP127M, ASP127N, ASP128M, ASP128N, ASP142M, ASP142N, ASP145M, ASP150M, ASP184N, ASP202N, ASP209N, ASP215M, ASP215N, ASP223M, ASP233N, ASP240N, ASP269N, ASP26N, ASP303M, ASP357M, ASP372M, ASP459M, ASP461M, ASP47M, CYS185N, CYS218M, CYS218N, CYS225M, CYS229N, CYS289N, CYS345M, GLN111M, GLN153M, GLN153N, GLN155N, GLN182N, GLN214M, GLN214N, GLN226M, GLN236N, GLN254M, GLN254N, GLN273N, GLN305M, GLN317N, GLN349M, GLN355M, GLN363M, GLN374M, GLN462M, GLN60M, GLU106M, GLU130M, GLU130N, GLU141M, GLU141N, GLU167N, GLU189N, GLU219N, GLU253N, GLU369M, GLU370M, GLY108M, GLY110M, GLY114M, GLY116M, GLY119M, GLY183N, GLY204N, GLY206N, GLY243N, GLY265N, GLY268N, GLY279N, GLY281N, GLY287N, GLY297M, GLY297N, GLY318N, GLY354M, GLY46M, GLY55M, GLY56M, GLY57M, HIS120M, HIS133M, HIS133N, HIS168N, HIS259M, HIS259N, HIS314N, HIS319N, HIS367M, ILE107M, ILE165N, ILE224M, ILE277N, ILE299M, ILE299N, ILE344M, ILE62M, LEU113M, LEU117M, LEU126M, LEU126N, LEU180N, LEU188N, LEU190N, LEU213N, LEU222M, LEU235N, LEU255N, LEU275N, LEU306N, LEU342M, LEU373M, LEU42M, LEU43M, LEU460M, LEU465M, LEU470M, LYS125M, LYS125N, LYS152N, LYS171N, LYS191N, LYS217M, LYS217N, LYS230N, LYS278N, LYS309M, LYS315N, LYS360M, LYS362M, LYS468M, LYS59M, LYS64M, MET208N, MET237N, MET267N, MET282N, PHE122M, PHE122N, PHE210N, PHE256M, PHE256N, PHE260M, PHE260N, PHE307M, PHE361M, PHE50M, PRO112M, PRO121M, PRO179N, PRO186N, PRO187N, PRO221M, PRO232N, PRO241N, PRO272N, PRO286N, PRO293N, PRO295M, PRO295N, PRO351M, PRO353M, PRO464M, PRO48M, PRO53M, SER118M, SER131N, SER132M, SER132N, SER137M, SER140N, SER148M, SER175N, SER177N, SER181N, SER227M, SER238N, SER274N, SER285N, SER288N, SER292N, SER294M, SER294N, SER296M, SER296N, SER298M, SER298N, SER302M, SER304M, SER304N, SER339M, SER347M, SER350M, SER365M, SER40M, THR129N, THR136M, THR136N, THR154N, THR203N, THR212N, THR216M, THR216N, THR266N, THR270N, THR280N, THR301M, THR337M, THR340M, THR343M, THR348M, THR359M, THR44M, TRP169N, TRP261M, TRP261N, TYR123M, TYR123N, TYR151M, TYR205N, TYR231N, TYR234N, TYR242N, TYR276N, TYR291N, TYR356M, TYR364M, TYR371M, TYR463M, TYR49M, TYR70N, VAL115M, VAL139N, VAL143M, VAL143N, VAL147M, VAL149M, VAL201N, VAL21N, VAL220M, VAL220N, VAL22N, VAL271N, VAL290N, VAL300M, VAL352M, VAL368M, VAL45M, VAL471M, VAL52M
• M-O: ALA284O, ARG283O, ASP357M, GLN273O, GLN355M, GLY279O, GLY281O, GLY354M, ILE277O, LYS278O, PHE361M, PRO353M, THR280O, TYR276O, TYR356M, VAL352M
• N-O: ALA134N, ALA134O, ALA135O, ALA170O, ALA207O, ALA20O, ALA239O, ALA257O, ALA264O, ALA284O, ALA316O, ALA346N, ALA358N, ALA54N, ARG109N, ARG144N, ARG144O, ARG178O, ARG251O, ARG252O, ARG258N, ARG258O, ARG263O, ARG283O, ARG338N, ARG366N, ARG41N, ARG467N, ARG51N, ASN124O, ASN146N, ASN192O, ASN23O, ASN262O, ASN308N, ASN320O, ASN341N, ASN58N, ASP127N, ASP127O, ASP128N, ASP128O, ASP142N, ASP142O, ASP145N, ASP150N, ASP184O, ASP202O, ASP209O, ASP215N, ASP215O, ASP223N, ASP233O, ASP240O, ASP269O, ASP26O, ASP303N, ASP357N, ASP372N, ASP459N, ASP461N, ASP47N, CYS185O, CYS218N, CYS218O, CYS225N, CYS229O, CYS289O, CYS345N, GLN111N, GLN153N, GLN153O, GLN155O, GLN182O, GLN214N, GLN214O, GLN226N, GLN226O, GLN236O, GLN254N, GLN254O, GLN273O, GLN305N, GLN317O, GLN349N, GLN355N, GLN363N, GLN374N, GLN462N, GLN60N, GLU106N, GLU130O, GLU141N, GLU141O, GLU167O, GLU189O, GLU219O, GLU253O, GLU369N, GLU370N, GLY108N, GLY110N, GLY114N, GLY116N, GLY119N, GLY166O, GLY183O, GLY204O, GLY206O, GLY243O, GLY265O, GLY268O, GLY279O, GLY281O, GLY287O, GLY297N, GLY297O, GLY318O, GLY354N, GLY46N, GLY55N, GLY56N, GLY57N, HIS120N, HIS133N, HIS133O, HIS168O, HIS259N, HIS259O, HIS314O, HIS319O, HIS367N, ILE107N, ILE165O, ILE224N, ILE277O, ILE299N, ILE299O, ILE344N, ILE62N, LEU113N, LEU117N, LEU126N, LEU126O, LEU180O, LEU188O, LEU190O, LEU213O, LEU222N, LEU235O, LEU255O, LEU275O, LEU306O, LEU342N, LEU373N, LEU42N, LEU43N, LEU460N, LEU465N, LEU470N, LYS125N, LYS125O, LYS152O, LYS171O, LYS191O, LYS217N, LYS217O, LYS230O, LYS278O, LYS309N, LYS315O, LYS360N, LYS362N, LYS468N, LYS59N, LYS64N, MET208O, MET237O, MET246O, MET267O, MET282O, PHE122N, PHE122O, PHE210O, PHE247O, PHE256N, PHE256O, PHE260N, PHE260O, PHE307N, PHE361N, PHE50N, PRO112N, PRO121N, PRO179O, PRO186O, PRO187O, PRO221N, PRO232O, PRO241O, PRO272O, PRO286O, PRO293O, PRO295N, PRO295O, PRO351N, PRO353N, PRO464N, PRO48N, PRO53N, SER118N, SER131O, SER132N, SER132O, SER137N, SER140O, SER148N, SER175O, SER177O, SER181O, SER227N, SER238O, SER274O, SER285O, SER288O, SER292O, SER294N, SER294O, SER296N, SER296O, SER298N, SER298O, SER302N, SER304N, SER304O, SER339N, SER347N, SER350N, SER365N, SER39N, SER40N, THR129O, THR136N, THR136O, THR154O, THR203O, THR212O, THR216N, THR216O, THR266O, THR270O, THR280O, THR301N, THR337N, THR340N, THR343N, THR348N, THR359N, THR44N, TRP169O, TRP261N, TRP261O, TYR123N, TYR123O, TYR151N, TYR205O, TYR231O, TYR234O, TYR242O, TYR276O, TYR291O, TYR356N, TYR364N, TYR371N, TYR391O, TYR463N, TYR49N, TYR70O, VAL115N, VAL139O, VAL143N, VAL143O, VAL147N, VAL149N, VAL201O, VAL21O, VAL220N, VAL220O, VAL22O, VAL271O, VAL290O, VAL300N, VAL352N, VAL368N, VAL45N, VAL471N, VAL52N