3OF3

crystal structure of pnp with an inhibitor dadme_immh from vibrio cholerae

• Total interactions analyzed: 66
• Total true interactions: 26
• Strongest Interaction:
  • Chains: H-J
  • Int. Res.: 148
  • Norm. En. per Res.: -5.792
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-3.9018	6.8339	-12.9297	-9.9977	15	1	0	561	0	13	13
A-C	-15.4974	63.9323	-458.817	-410.3821	167	10	6	20314	0	60	42
A-E	-135.2627	-174.4495	-549.753	-859.4652	150	18	20	18792	11	65	63
A-L	0.0	7.6982	-11.7754	-4.0772	15	1	0	557	0	12	13
B-D	-133.5031	-161.7025	-536.758	-831.9637	147	25	20	18307	10	64	63
B-E	-20.1142	58.3876	-455.983	-417.7096	167	12	6	20288	0	60	43
B-L	-4.9126	6.7749	-12.903	-11.0407	15	1	0	562	0	12	14
C-D	0.0	7.0192	-12.0996	-5.0804	15	1	0	556	0	12	14
C-E	0.0	7.7125	-12.5957	-4.8832	15	1	0	576	0	12	14
C-L	-146.7746	-172.4337	-543.769	-862.9773	150	21	20	18867	13	64	63
D-E	0.0	7.3795	-12.5846	-5.2051	15	1	0	563	0	13	14
D-K	-18.2984	10.0295	-26.1612	-34.4301	32	2	0	1356	0	12	12
D-L	-12.1277	61.4736	-456.403	-407.0571	166	8	6	20093	0	59	42
F-G	0.0	7.5605	-12.2037	-4.6433	15	1	0	563	0	12	13
F-H	-5.0175	7.271	-13.1998	-10.9463	15	1	0	566	0	13	14
F-I	-131.0543	-170.4863	-551.723	-853.2636	149	28	20	18884	12	64	63
F-J	-13.8948	55.6417	-453.448	-411.7011	166	11	6	20068	0	60	42
G-H	0.0	7.5512	-12.8372	-5.286	15	1	0	556	0	13	14
G-I	-16.9621	59.0048	-456.26	-414.2173	166	10	6	20224	0	60	42
G-K	-133.0907	-175.9809	-546.225	-855.2966	148	21	20	18702	12	64	63
G-L	-17.2258	8.3491	-23.73	-32.6067	32	1	0	1299	0	10	13
H-J	-143.4697	-169.8373	-543.911	-857.2181	148	25	20	18755	12	64	63
H-K	-17.3035	55.4888	-451.087	-412.9017	167	11	6	19880	0	59	42
I-J	-4.1638	5.3561	-13.0067	-11.8144	15	1	0	560	0	13	14
I-K	0.0	7.3572	-13.0598	-5.7026	15	1	0	564	0	13	14
J-K	0.0	7.1368	-6.8755	0.2613	15	1	0	558	0	13	14

Interface residues

• A-B: ARG131A, ARG131B, ASP136A, ASP136B, ASP138A, HIS137A, ILE132B, LEU172B, LYS128B, LYS135A, LYS186A, PHE134A, PRO176B, TYR187A, VAL129B
• A-C: ALA15A, ALA15C, ALA170A, ALA170C, ALA39A, ALA39C, ARG101A, ARG101C, ARG131A, ARG131C, ARG133A, ARG133C, ARG231A, ARG231C, ARG38A, ARG38C, ARG57A, ARG57C, ASN130A, ASN130C, ASN20A, ASN20C, ASN58A, ASN58C, ASP126A, ASP126C, ASP136A, ASP136C, ASP177A, ASP177C, ASP218A, ASP218C, ASP35A, ASP35C, ASP55A, ASP55C, ASP93A, ASP93C, CYS83A, CYS83C, GLN225A, GLN225C, GLN232A, GLN232C, GLN52A, GLN52C, GLU171A, GLU171C, GLU195A, GLU195C, GLU205A, GLU205C, GLU229A, GLU229C, GLU89A, GLU89C, GLY103A, GLY103C, GLY198A, GLY198C, GLY201A, GLY201C, GLY34A, GLY34C, GLY75A, GLY75C, GLY77A, GLY77C, GLY79A, GLY79C, HIS18A, HIS18C, HIS76A, HIS76C, ILE132A, ILE132C, ILE19A, ILE19C, ILE80A, ILE80C, ILE85A, ILE85C, LEU172A, LEU172C, LEU37A, LEU37C, LEU90A, LEU90C, LYS128A, LYS128C, LYS135A, LYS135C, LYS40A, LYS40C, LYS92A, LYS92C, MET180A, MET180C, MET194A, MET194C, MET59A, MET59C, MET74A, MET74C, MET78A, MET78C, PHE134A, PHE134C, PHE168A, PHE168C, PHE173A, PHE173C, PHE235A, PHE235C, PHE60A, PHE60C, PRO176A, PRO176C, PRO17A, PRO17C, PRO33A, PRO33C, PRO36A, PRO36C, PRO81A, PRO81C, SER104A, SER104C, SER127A, SER127C, SER217A, SER217C, SER228A, SER228C, SER82A, SER82C, SER84A, SER84C, THR125A, THR125C, THR16A, THR16C, THR175A, THR175C, THR226A, THR226C, THR227A, THR227C, THR88A, THR88C, TYR174A, TYR174C, TYR206A, TYR206C, TYR62A, TYR62C, TYR86A, TYR86C, TYR94C, VAL129A, VAL129C, VAL202A, VAL202C, VAL56A, VAL56C, VAL87A, VAL87C
• A-E: ALA123A, ALA123E, ALA140A, ALA140E, ALA141A, ALA141E, ALA143A, ALA143E, ALA150A, ALA150E, ALA151A, ALA151E, ALA197A, ALA197E, ALA203A, ALA203E, ALA204A, ALA204E, ALA210A, ALA210E, ALA252A, ALA252E, ARG131A, ARG131E, ARG133A, ARG133E, ASN130A, ASN130E, ASN166A, ASN166E, ASP126A, ASP126E, ASP136A, ASP136E, ASP138A, ASP138E, ASP144A, ASP144E, ASP177A, ASP177E, ASP182A, ASP182E, ASP185A, ASP185E, CYS124A, CYS124E, GLU152A, GLU152E, GLU153A, GLU153E, GLU171A, GLU171E, GLU205A, GLU205E, GLY120A, GLY120E, GLY122A, GLY122E, GLY165A, GLY165E, GLY188A, GLY188E, GLY201A, GLY201E, GLY207A, GLY207E, GLY253A, GLY253E, HIS137A, HIS137E, ILE119A, ILE119E, ILE132A, ILE132E, ILE142A, ILE142E, ILE189A, ILE189E, LEU167A, LEU167E, LEU211A, LEU211E, LYS128A, LYS128E, LYS135A, LYS135E, LYS146A, LYS146E, LYS149A, LYS149E, LYS156A, LYS156E, LYS163A, LYS163E, LYS186A, LYS186E, MET121A, MET121E, MET147A, MET147E, MET180A, MET180E, MET184A, MET184E, PHE134A, PHE134E, PHE139A, PHE139E, PHE168A, PHE168E, PHE181A, PHE181E, PRO176A, PRO176E, PRO178A, PRO178E, SER127A, SER127E, SER169A, SER169E, SER179A, SER179E, THR125A, THR125E, THR175A, THR175E, TYR145A, TYR145E, TYR187A, TYR187E, TYR200A, TYR200E, TYR206A, TYR206E, TYR254A, TYR254E, VAL129A, VAL129E, VAL148A, VAL148E, VAL162A, VAL162E, VAL164A, VAL164E, VAL183A, VAL183E, VAL190A, VAL190E, VAL202A, VAL202E
• A-L: ARG131A, ARG131L, ASP136A, ASP136L, ASP138L, HIS137L, ILE132A, LEU172A, LYS128A, LYS135L, LYS186L, PHE134L, PRO176A, TYR187L, VAL129A
• B-D: ALA123B, ALA123D, ALA140B, ALA140D, ALA141B, ALA141D, ALA143B, ALA143D, ALA150B, ALA150D, ALA151B, ALA151D, ALA197B, ALA197D, ALA203B, ALA203D, ALA204B, ALA204D, ALA210B, ALA210D, ALA252B, ALA252D, ARG131B, ARG131D, ARG133B, ARG133D, ASN130B, ASN130D, ASN166B, ASN166D, ASP126B, ASP126D, ASP136B, ASP136D, ASP138B, ASP138D, ASP144B, ASP144D, ASP177B, ASP177D, ASP182B, ASP182D, ASP185B, ASP185D, CYS124B, CYS124D, GLU152B, GLU152D, GLU153B, GLU153D, GLU171B, GLU171D, GLU205B, GLU205D, GLY120B, GLY120D, GLY122B, GLY122D, GLY165B, GLY165D, GLY188B, GLY188D, GLY201B, GLY201D, GLY207B, GLY207D, GLY253B, HIS137B, HIS137D, ILE119B, ILE119D, ILE132B, ILE132D, ILE142B, ILE142D, ILE189B, ILE189D, LEU167B, LEU167D, LEU211B, LEU211D, LYS128B, LYS128D, LYS135B, LYS135D, LYS146B, LYS146D, LYS149B, LYS149D, LYS156B, LYS156D, LYS163B, LYS163D, LYS186B, LYS186D, MET121B, MET121D, MET147B, MET147D, MET180B, MET180D, MET184B, MET184D, PHE134B, PHE134D, PHE139B, PHE139D, PHE168B, PHE168D, PHE181B, PHE181D, PRO176B, PRO178B, PRO178D, SER127B, SER127D, SER169B, SER169D, SER179B, SER179D, THR125B, THR125D, THR175B, THR175D, TYR145B, TYR145D, TYR187B, TYR187D, TYR200B, TYR200D, TYR206B, TYR206D, TYR254B, VAL129B, VAL129D, VAL148B, VAL148D, VAL162B, VAL162D, VAL164B, VAL164D, VAL183B, VAL183D, VAL190B, VAL190D, VAL202B, VAL202D
• B-E: ALA15B, ALA15E, ALA170B, ALA170E, ALA39B, ALA39E, ARG101B, ARG101E, ARG131B, ARG131E, ARG133B, ARG133E, ARG231B, ARG231E, ARG38B, ARG38E, ARG57B, ARG57E, ASN130B, ASN130E, ASN20B, ASN20E, ASN58B, ASN58E, ASP126B, ASP126E, ASP136B, ASP136E, ASP177B, ASP177E, ASP218B, ASP218E, ASP35B, ASP35E, ASP55B, ASP55E, ASP93B, ASP93E, CYS83B, CYS83E, GLN225B, GLN225E, GLN232B, GLN232E, GLN52B, GLN52E, GLU171B, GLU171E, GLU195B, GLU195E, GLU205B, GLU205E, GLU229B, GLU229E, GLU89B, GLU89E, GLY103B, GLY103E, GLY198B, GLY198E, GLY201B, GLY201E, GLY34B, GLY34E, GLY75B, GLY75E, GLY77B, GLY77E, GLY79B, GLY79E, HIS18B, HIS18E, HIS76B, HIS76E, ILE132B, ILE132E, ILE19B, ILE19E, ILE80B, ILE80E, ILE85B, ILE85E, LEU172B, LEU172E, LEU37B, LEU37E, LEU90B, LEU90E, LYS128B, LYS128E, LYS135B, LYS135E, LYS40B, LYS40E, LYS92B, LYS92E, MET180B, MET180E, MET194B, MET194E, MET59B, MET59E, MET74B, MET74E, MET78B, MET78E, PHE134B, PHE134E, PHE168B, PHE168E, PHE173B, PHE173E, PHE235B, PHE235E, PHE60B, PHE60E, PRO176B, PRO176E, PRO17B, PRO17E, PRO33B, PRO33E, PRO36B, PRO36E, PRO81B, PRO81E, SER104B, SER104E, SER127B, SER127E, SER217B, SER217E, SER228B, SER228E, SER82B, SER82E, SER84B, SER84E, THR125B, THR125E, THR16B, THR16E, THR175B, THR175E, THR226B, THR226E, THR227B, THR227E, THR88B, THR88E, TYR174B, TYR174E, TYR206B, TYR206E, TYR62B, TYR62E, TYR86B, TYR86E, TYR94B, VAL129B, VAL129E, VAL202B, VAL202E, VAL56B, VAL56E, VAL87B, VAL87E
• B-L: ARG131B, ARG131L, ASP136B, ASP136L, ASP138B, HIS137B, ILE132L, LEU172L, LYS128L, LYS135B, LYS186B, PHE134B, PRO176L, TYR187B, VAL129L
• C-D: ARG131C, ARG131D, ASP136C, ASP136D, ASP138C, HIS137C, ILE132D, LEU172D, LYS128D, LYS135C, LYS186C, PHE134C, PRO176D, TYR187C, VAL129D
• C-E: ARG131C, ARG131E, ASP136C, ASP136E, ASP138E, HIS137E, ILE132C, LEU172C, LYS128C, LYS135E, LYS186E, PHE134E, PRO176C, TYR187E, VAL129C
• C-L: ALA123C, ALA123L, ALA140C, ALA140L, ALA141C, ALA141L, ALA143C, ALA143L, ALA150C, ALA150L, ALA151C, ALA151L, ALA154L, ALA197C, ALA197L, ALA203C, ALA203L, ALA204C, ALA204L, ALA210C, ALA210L, ALA252L, ARG131C, ARG131L, ARG133C, ARG133L, ASN130C, ASN130L, ASN166C, ASN166L, ASP126C, ASP126L, ASP136C, ASP136L, ASP138C, ASP138L, ASP144C, ASP144L, ASP177C, ASP177L, ASP182C, ASP182L, ASP185C, ASP185L, CYS124C, CYS124L, GLU152C, GLU152L, GLU153C, GLU153L, GLU171C, GLU171L, GLU205C, GLU205L, GLY120C, GLY120L, GLY122C, GLY122L, GLY165C, GLY165L, GLY188C, GLY188L, GLY201C, GLY201L, GLY207C, GLY207L, GLY253C, GLY253L, HIS137C, HIS137L, ILE119C, ILE119L, ILE132C, ILE132L, ILE142C, ILE142L, ILE189C, ILE189L, LEU167C, LEU167L, LEU211C, LEU211L, LYS128C, LYS128L, LYS135C, LYS135L, LYS146C, LYS146L, LYS149C, LYS149L, LYS156C, LYS156L, LYS163C, LYS163L, LYS186C, LYS186L, MET121C, MET121L, MET147C, MET147L, MET180C, MET180L, MET184C, MET184L, PHE134C, PHE134L, PHE139C, PHE139L, PHE168C, PHE168L, PHE181C, PHE181L, PRO176L, PRO178C, PRO178L, SER127C, SER127L, SER169C, SER169L, SER179C, SER179L, THR125C, THR125L, THR175C, THR175L, TYR145C, TYR145L, TYR187C, TYR187L, TYR200C, TYR200L, TYR206C, TYR206L, TYR254C, TYR254L, VAL129C, VAL129L, VAL148C, VAL148L, VAL162C, VAL162L, VAL164C, VAL164L, VAL183C, VAL183L, VAL190C, VAL190L, VAL192L, VAL202C, VAL202L
• D-E: ARG131D, ARG131E, ASP136D, ASP136E, ASP138D, HIS137D, ILE132E, LEU172E, LYS128E, LYS135D, LYS186D, PHE134D, PRO176E, TYR187D, VAL129E
• D-K: ALA157K, ALA252K, ALA43D, ALA50D, ARG158K, ARG69K, ASN233D, ASN45D, ASN49D, ASP244K, ASP250K, ASP48D, ASP48K, GLN251K, GLN52D, GLU153K, GLU44D, GLY68K, ILE248K, ILE42D, LEU247K, LEU47D, LYS40D, LYS67K, LYS70K, PHE46D, THR65D, THR65K, TYR41D, TYR62D, TYR66K, VAL51D
• D-L: ALA15D, ALA15L, ALA170D, ALA170L, ALA39D, ALA39L, ARG101D, ARG101L, ARG131D, ARG131L, ARG133D, ARG133L, ARG231D, ARG231L, ARG38D, ARG38L, ARG57D, ARG57L, ASN130D, ASN130L, ASN20D, ASN20L, ASN58D, ASN58L, ASP126D, ASP126L, ASP136D, ASP136L, ASP177D, ASP177L, ASP218D, ASP218L, ASP35D, ASP35L, ASP55D, ASP55L, ASP93D, ASP93L, CYS83D, CYS83L, GLN225D, GLN225L, GLN232D, GLN232L, GLN52D, GLN52L, GLU171D, GLU171L, GLU195D, GLU195L, GLU205D, GLU205L, GLU229D, GLU229L, GLU89D, GLU89L, GLY103D, GLY103L, GLY198D, GLY198L, GLY201D, GLY201L, GLY34D, GLY34L, GLY75D, GLY75L, GLY77D, GLY77L, GLY79D, GLY79L, HIS18D, HIS18L, HIS76D, HIS76L, ILE132D, ILE132L, ILE19D, ILE19L, ILE80D, ILE80L, ILE85D, ILE85L, LEU172D, LEU172L, LEU37D, LEU37L, LEU90D, LEU90L, LYS128D, LYS128L, LYS135D, LYS135L, LYS40D, LYS40L, LYS92D, LYS92L, MET180D, MET180L, MET194D, MET194L, MET59D, MET59L, MET74D, MET74L, MET78D, MET78L, PHE134D, PHE134L, PHE168D, PHE168L, PHE173D, PHE173L, PHE235D, PHE235L, PHE60D, PHE60L, PRO176D, PRO176L, PRO17D, PRO17L, PRO33D, PRO33L, PRO36D, PRO36L, PRO81D, PRO81L, SER104D, SER104L, SER127D, SER127L, SER217D, SER217L, SER228D, SER228L, SER82D, SER82L, SER84D, SER84L, THR125D, THR125L, THR16D, THR16L, THR175D, THR175L, THR226D, THR226L, THR227D, THR227L, THR88D, THR88L, TYR174D, TYR174L, TYR206D, TYR206L, TYR62D, TYR62L, TYR86D, TYR86L, VAL129D, VAL129L, VAL202D, VAL202L, VAL56D, VAL56L, VAL87D, VAL87L
• F-G: ARG131F, ARG131G, ASP136F, ASP136G, ASP138F, HIS137F, ILE132G, LEU172G, LYS128G, LYS135F, LYS186F, PHE134F, PRO176G, TYR187F, VAL129G
• F-H: ARG131F, ARG131H, ASP136F, ASP136H, ASP138H, HIS137H, ILE132F, LEU172F, LYS128F, LYS135H, LYS186H, PHE134H, PRO176F, TYR187H, VAL129F
• F-I: ALA123F, ALA123I, ALA140F, ALA140I, ALA141F, ALA141I, ALA143F, ALA143I, ALA150F, ALA150I, ALA151F, ALA151I, ALA197F, ALA197I, ALA203F, ALA203I, ALA204F, ALA204I, ALA210F, ALA210I, ALA252F, ARG131F, ARG131I, ARG133F, ARG133I, ASN130F, ASN130I, ASN166F, ASN166I, ASP126F, ASP126I, ASP136F, ASP136I, ASP138F, ASP138I, ASP144F, ASP144I, ASP177F, ASP177I, ASP182F, ASP182I, ASP185F, ASP185I, CYS124F, CYS124I, GLU152F, GLU152I, GLU153F, GLU153I, GLU171F, GLU171I, GLU205F, GLU205I, GLY120F, GLY120I, GLY122F, GLY122I, GLY165F, GLY165I, GLY188F, GLY188I, GLY201F, GLY201I, GLY207F, GLY207I, GLY253F, GLY253I, HIS137F, HIS137I, ILE119F, ILE119I, ILE132F, ILE132I, ILE142F, ILE142I, ILE189F, ILE189I, LEU167F, LEU167I, LEU211F, LEU211I, LYS128F, LYS128I, LYS135F, LYS135I, LYS146F, LYS146I, LYS149F, LYS149I, LYS156F, LYS156I, LYS163F, LYS163I, LYS186F, LYS186I, MET121F, MET121I, MET147F, MET147I, MET180F, MET180I, MET184F, MET184I, PHE134F, PHE134I, PHE139F, PHE139I, PHE168F, PHE168I, PHE181F, PHE181I, PRO176F, PRO176I, PRO178F, PRO178I, SER127F, SER127I, SER169F, SER169I, SER179F, SER179I, THR125F, THR125I, THR175F, THR175I, TYR145F, TYR145I, TYR187F, TYR187I, TYR200F, TYR200I, TYR206F, TYR206I, TYR254F, TYR254I, VAL129F, VAL129I, VAL148F, VAL148I, VAL162F, VAL162I, VAL164F, VAL164I, VAL183F, VAL183I, VAL190F, VAL190I, VAL202F, VAL202I
• F-J: ALA15F, ALA15J, ALA170F, ALA170J, ALA39F, ALA39J, ARG101F, ARG101J, ARG131F, ARG131J, ARG133F, ARG133J, ARG231F, ARG231J, ARG38F, ARG38J, ARG57F, ARG57J, ASN130F, ASN130J, ASN20F, ASN20J, ASN58F, ASN58J, ASP126F, ASP126J, ASP136F, ASP136J, ASP177F, ASP177J, ASP218F, ASP218J, ASP35F, ASP35J, ASP55F, ASP55J, ASP93F, ASP93J, CYS83F, CYS83J, GLN225F, GLN225J, GLN232F, GLN232J, GLN52F, GLN52J, GLU171F, GLU171J, GLU195F, GLU195J, GLU205F, GLU205J, GLU229F, GLU229J, GLU89F, GLU89J, GLY103F, GLY103J, GLY198F, GLY198J, GLY201F, GLY201J, GLY34F, GLY34J, GLY75F, GLY75J, GLY77F, GLY77J, GLY79F, GLY79J, HIS18F, HIS18J, HIS76F, HIS76J, ILE132F, ILE132J, ILE19F, ILE19J, ILE80F, ILE80J, ILE85F, ILE85J, LEU172F, LEU172J, LEU37F, LEU37J, LEU90F, LEU90J, LYS128F, LYS128J, LYS135F, LYS135J, LYS40F, LYS40J, LYS92F, LYS92J, MET180F, MET180J, MET194F, MET194J, MET59F, MET59J, MET74F, MET74J, MET78F, MET78J, PHE134F, PHE134J, PHE168F, PHE168J, PHE173F, PHE173J, PHE235F, PHE235J, PHE60F, PHE60J, PRO176F, PRO176J, PRO17F, PRO17J, PRO33F, PRO33J, PRO36F, PRO36J, PRO81F, PRO81J, SER104F, SER104J, SER127F, SER127J, SER217F, SER217J, SER228F, SER228J, SER82F, SER82J, SER84F, SER84J, THR125F, THR125J, THR16F, THR16J, THR175F, THR175J, THR226F, THR226J, THR227F, THR227J, THR88F, THR88J, TYR174F, TYR174J, TYR206F, TYR206J, TYR62F, TYR62J, TYR86F, TYR86J, VAL129F, VAL129J, VAL202F, VAL202J, VAL56F, VAL56J, VAL87F, VAL87J
• G-H: ARG131G, ARG131H, ASP136G, ASP136H, ASP138G, HIS137G, ILE132H, LEU172H, LYS128H, LYS135G, LYS186G, PHE134G, PRO176H, TYR187G, VAL129H
• G-I: ALA15G, ALA15I, ALA170G, ALA170I, ALA39G, ALA39I, ARG101G, ARG101I, ARG131G, ARG131I, ARG133G, ARG133I, ARG231G, ARG231I, ARG38G, ARG38I, ARG57G, ARG57I, ASN130G, ASN130I, ASN20G, ASN20I, ASN58G, ASN58I, ASP126G, ASP126I, ASP136G, ASP136I, ASP177G, ASP177I, ASP218G, ASP218I, ASP35G, ASP35I, ASP55G, ASP55I, ASP93G, ASP93I, CYS83G, CYS83I, GLN225G, GLN225I, GLN232G, GLN232I, GLN52G, GLN52I, GLU171G, GLU171I, GLU195G, GLU195I, GLU205G, GLU205I, GLU229G, GLU229I, GLU89G, GLU89I, GLY103G, GLY103I, GLY198G, GLY198I, GLY201G, GLY201I, GLY34G, GLY34I, GLY75G, GLY75I, GLY77G, GLY77I, GLY79G, GLY79I, HIS18G, HIS18I, HIS76G, HIS76I, ILE132G, ILE132I, ILE19G, ILE19I, ILE80G, ILE80I, ILE85G, ILE85I, LEU172G, LEU172I, LEU37G, LEU37I, LEU90G, LEU90I, LYS128G, LYS128I, LYS135G, LYS40G, LYS40I, LYS92G, LYS92I, MET180G, MET180I, MET194G, MET194I, MET59G, MET59I, MET74G, MET74I, MET78G, MET78I, PHE134G, PHE134I, PHE168G, PHE168I, PHE173G, PHE173I, PHE235G, PHE235I, PHE60G, PHE60I, PRO176G, PRO176I, PRO17G, PRO17I, PRO33G, PRO33I, PRO36G, PRO36I, PRO81G, PRO81I, SER104G, SER104I, SER127G, SER127I, SER217G, SER217I, SER228G, SER228I, SER82G, SER82I, SER84G, SER84I, THR125G, THR125I, THR16G, THR16I, THR175G, THR175I, THR226G, THR226I, THR227G, THR227I, THR88G, THR88I, TYR174G, TYR174I, TYR206G, TYR206I, TYR62G, TYR62I, TYR86G, TYR86I, TYR94I, VAL129G, VAL129I, VAL202G, VAL202I, VAL56G, VAL56I, VAL87G, VAL87I
• G-K: ALA123G, ALA123K, ALA140G, ALA140K, ALA141G, ALA141K, ALA143G, ALA143K, ALA150G, ALA150K, ALA151G, ALA151K, ALA197G, ALA197K, ALA203G, ALA203K, ALA204G, ALA204K, ALA210G, ALA210K, ALA252G, ALA252K, ARG131G, ARG131K, ARG133G, ARG133K, ASN130G, ASN130K, ASN166G, ASN166K, ASP126G, ASP126K, ASP136G, ASP136K, ASP138G, ASP138K, ASP144G, ASP144K, ASP177G, ASP177K, ASP182G, ASP182K, ASP185G, ASP185K, CYS124G, CYS124K, GLU152G, GLU152K, GLU153G, GLU153K, GLU171G, GLU171K, GLU205G, GLU205K, GLY120G, GLY120K, GLY122G, GLY122K, GLY165G, GLY165K, GLY188G, GLY188K, GLY201G, GLY201K, GLY207G, GLY207K, GLY253G, GLY253K, HIS137G, HIS137K, ILE119G, ILE119K, ILE132G, ILE132K, ILE142G, ILE142K, ILE189G, ILE189K, LEU167G, LEU167K, LEU211G, LEU211K, LYS128G, LYS128K, LYS135G, LYS135K, LYS146G, LYS146K, LYS149G, LYS149K, LYS156G, LYS156K, LYS163G, LYS163K, LYS186G, LYS186K, MET121G, MET121K, MET147G, MET147K, MET180G, MET180K, MET184G, MET184K, PHE134G, PHE134K, PHE139G, PHE139K, PHE168G, PHE168K, PHE181G, PHE181K, PRO178G, PRO178K, SER127G, SER127K, SER169G, SER169K, SER179G, SER179K, THR125G, THR125K, THR175G, THR175K, TYR145G, TYR145K, TYR187G, TYR187K, TYR200G, TYR200K, TYR206G, TYR206K, TYR254G, TYR254K, VAL129G, VAL129K, VAL148G, VAL148K, VAL162G, VAL162K, VAL164G, VAL164K, VAL183G, VAL183K, VAL190G, VAL190K, VAL202G, VAL202K
• G-L: ALA157G, ALA252G, ALA43L, ALA50L, ARG158G, ARG69G, ASN45L, ASN49L, ASP244G, ASP250G, ASP48G, ASP48L, GLN251G, GLN52L, GLU153G, GLU44L, GLY68G, ILE248G, ILE42L, LEU247G, LEU47L, LYS40L, LYS67G, LYS70G, PHE46L, THR65G, THR65L, TYR41L, TYR62L, TYR66G, VAL51L, VAL53L
• H-J: ALA123H, ALA123J, ALA140H, ALA140J, ALA141H, ALA141J, ALA143H, ALA143J, ALA150H, ALA150J, ALA151H, ALA151J, ALA197H, ALA197J, ALA203H, ALA203J, ALA204H, ALA204J, ALA210H, ALA210J, ALA252H, ALA252J, ARG131H, ARG131J, ARG133H, ARG133J, ASN130H, ASN130J, ASN166H, ASN166J, ASP126H, ASP126J, ASP136H, ASP136J, ASP138H, ASP138J, ASP144H, ASP144J, ASP177H, ASP177J, ASP182H, ASP182J, ASP185H, ASP185J, CYS124H, CYS124J, GLU152H, GLU152J, GLU153H, GLU153J, GLU171H, GLU171J, GLU205H, GLU205J, GLY120H, GLY120J, GLY122H, GLY122J, GLY165H, GLY165J, GLY188H, GLY188J, GLY201H, GLY201J, GLY207H, GLY207J, GLY253H, GLY253J, HIS137H, HIS137J, ILE119H, ILE119J, ILE132H, ILE132J, ILE142H, ILE142J, ILE189H, ILE189J, LEU167H, LEU167J, LEU211H, LEU211J, LYS128H, LYS128J, LYS135H, LYS135J, LYS146H, LYS146J, LYS149H, LYS149J, LYS156H, LYS156J, LYS163H, LYS163J, LYS186H, LYS186J, MET121H, MET121J, MET147H, MET147J, MET180H, MET180J, MET184H, MET184J, PHE134H, PHE134J, PHE139H, PHE139J, PHE168H, PHE168J, PHE181H, PHE181J, PRO178H, PRO178J, SER127H, SER127J, SER169H, SER169J, SER179H, SER179J, THR125H, THR125J, THR175H, THR175J, TYR145H, TYR145J, TYR187H, TYR187J, TYR200H, TYR200J, TYR206H, TYR206J, TYR254H, TYR254J, VAL129H, VAL129J, VAL148H, VAL148J, VAL162H, VAL162J, VAL164H, VAL164J, VAL183H, VAL183J, VAL190H, VAL190J, VAL202H, VAL202J
• H-K: ALA15H, ALA15K, ALA170H, ALA170K, ALA39H, ALA39K, ARG101H, ARG101K, ARG131H, ARG131K, ARG133H, ARG133K, ARG231H, ARG231K, ARG38H, ARG38K, ARG57H, ARG57K, ASN130H, ASN130K, ASN20H, ASN20K, ASN58H, ASN58K, ASP126H, ASP126K, ASP136H, ASP136K, ASP177H, ASP177K, ASP218H, ASP218K, ASP35H, ASP35K, ASP55H, ASP55K, ASP93H, ASP93K, CYS83H, CYS83K, GLN225H, GLN225K, GLN232H, GLN232K, GLN52H, GLN52K, GLU171H, GLU171K, GLU195H, GLU195K, GLU205H, GLU205K, GLU229H, GLU229K, GLU89H, GLU89K, GLY103H, GLY103K, GLY198H, GLY198K, GLY201H, GLY201K, GLY34H, GLY34K, GLY75H, GLY75K, GLY77H, GLY77K, GLY79H, GLY79K, HIS18H, HIS18K, HIS76H, HIS76K, ILE132H, ILE132K, ILE19H, ILE19K, ILE80H, ILE80K, ILE85H, ILE85K, LEU172H, LEU172K, LEU37H, LEU37K, LEU90H, LEU90K, LYS128H, LYS128K, LYS135H, LYS135K, LYS40H, LYS40K, LYS92H, LYS92K, MET180H, MET180K, MET194H, MET194K, MET59H, MET59K, MET74H, MET74K, MET78H, MET78K, PHE134H, PHE134K, PHE168H, PHE168K, PHE173H, PHE173K, PHE235H, PHE235K, PHE60H, PHE60K, PRO176H, PRO176K, PRO17H, PRO17K, PRO33H, PRO33K, PRO36H, PRO36K, PRO81H, PRO81K, SER104H, SER104K, SER127H, SER127K, SER217H, SER217K, SER228H, SER228K, SER82H, SER82K, SER84H, SER84K, THR125H, THR125K, THR16H, THR16K, THR175H, THR175K, THR226H, THR226K, THR227H, THR227K, THR88H, THR88K, TYR174H, TYR174K, TYR206H, TYR206K, TYR62H, TYR62K, TYR86H, TYR86K, TYR94H, VAL129H, VAL129K, VAL202H, VAL202K, VAL56H, VAL56K, VAL87H, VAL87K
• I-J: ARG131I, ARG131J, ASP136I, ASP136J, ASP138I, HIS137I, ILE132J, LEU172J, LYS128J, LYS135I, LYS186I, PHE134I, PRO176J, TYR187I, VAL129J
• I-K: ARG131I, ARG131K, ASP136I, ASP136K, ASP138K, HIS137K, ILE132I, LEU172I, LYS128I, LYS135K, LYS186K, PHE134K, PRO176I, TYR187K, VAL129I
• J-K: ARG131J, ARG131K, ASP136J, ASP136K, ASP138J, HIS137J, ILE132K, LEU172K, LYS128K, LYS135J, LYS186J, PHE134J, PRO176K, TYR187J, VAL129K