3OBV

autoinhibited formin mdia1 structure

• Total interactions analyzed: 28
• Total true interactions: 11
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 196
  • Norm. En. per Res.: -6.4446
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-90.6668	-146.0344	-1007.38	-1244.0813	196	35	58	41796	10	101	92
A-F	-68.6907	-90.386	-366.264	-525.3407	135	15	11	15899	6	75	35
A-C	0.0	-28.6194	-42.9206	-71.54	44	0	0	1943	0	20	22
A-D	-37.5478	1.1551	-103.038	-139.4308	45	4	3	3707	1	26	24
E-B	-58.7227	-70.8925	-317.233	-446.8482	133	26	12	14749	7	67	31
E-F	-112.4858	-53.187	-1093.69	-1259.3627	247	49	40	42559	5	42	61
B-C	-32.8635	-3.5048	-95.2703	-131.6386	44	7	3	3679	1	25	24
C-D	-104.6929	-147.2759	-1011.17	-1263.1388	196	44	59	41998	12	103	92
C-H	-69.952	-90.8075	-354.206	-514.9655	135	11	11	15659	6	76	35
G-D	-53.9611	-92.3531	-317.771	-464.0852	132	24	12	15288	7	72	32
G-H	-109.4336	-59.0245	-1075.29	-1243.7481	247	68	39	42710	5	42	61

Interface residues

• A-B: ALA397A, ALA397B, ALA417A, ALA417B, ARG322A, ARG322B, ARG326A, ARG326B, ARG331A, ARG331B, ARG370A, ARG370B, ARG375A, ARG375B, ARG412A, ARG412B, ARG418A, ARG418B, ARG446A, ARG446B, ARG454B, ASN390A, ASN390B, ASN413A, ASN413B, ASP320A, ASP320B, ASP366A, ASP366B, ASP372A, ASP372B, ASP373A, ASP373B, ASP379A, ASP379B, ASP380A, ASP380B, ASP394A, ASP394B, ASP414A, ASP414B, ASP440A, ASP440B, ASP442A, ASP442B, ASP451A, ASP451B, CYS428A, CYS428B, CYS445A, CYS445B, GLN386A, GLN386B, GLN406A, GLN406B, GLN420A, GLN420B, GLN431A, GLN431B, GLN449A, GLN449B, GLU328A, GLU328B, GLU377A, GLU377B, GLU383A, GLU383B, GLU398A, GLU398B, GLU416A, GLU416B, GLU426A, GLU426B, GLU427A, GLU427B, GLU453B, GLY369A, GLY369B, GLY382A, GLY382B, GLY438A, GLY438B, HIS324A, HIS324B, HIS400A, HIS400B, HIS407A, HIS407B, HIS435A, HIS435B, HIS447A, HIS447B, ILE325A, ILE325B, ILE374A, ILE374B, ILE387A, ILE387B, ILE388A, ILE388B, ILE404A, ILE404B, ILE425A, ILE425B, ILE432A, ILE432B, ILE450A, ILE450B, ILE452A, ILE452B, LEU319A, LEU319B, LEU367A, LEU367B, LEU371A, LEU371B, LEU389A, LEU389B, LEU402A, LEU402B, LEU405A, LEU405B, LEU408A, LEU408B, LEU409A, LEU409B, LEU410A, LEU410B, LEU424A, LEU424B, LEU434A, LEU434B, LEU448A, LEU448B, LYS368A, LYS368B, LYS393A, LYS393B, LYS396A, LYS396B, LYS423A, LYS423B, LYS444A, LYS444B, MET376A, MET376B, MET378A, MET378B, PHE321A, PHE321B, PHE364A, PHE364B, PHE381A, PHE381B, PHE385A, PHE385B, PHE401A, PHE401B, PHE443A, PHE443B, PRO399A, PRO399B, PRO419A, PRO419B, PRO441A, PRO441B, SER327A, SER327B, SER395A, SER395B, SER403A, SER403B, SER430A, SER430B, THR391A, THR391B, THR439A, THR439B, TYR415A, TYR415B, TYR421A, TYR421B, TYR422A, TYR422B, VAL323A, VAL323B, VAL384A, VAL384B, VAL392A, VAL392B, VAL411A, VAL411B, VAL429A, VAL429B, VAL433A, VAL433B
• A-F: ALA1148F, ALA1151F, ALA1155F, ALA1174F, ALA1188F, ALA1193F, ALA1194F, ALA214A, ALA251A, ALA256A, ALA300A, ALA311A, ALA316A, ARG1147F, ARG1159F, ARG1166F, ARG1196F, ARG322A, ARG375A, ASN1173F, ASN164A, ASN165A, ASN166A, ASN217A, ASN218A, ASN267A, ASN310A, ASN346A, ASP1171F, ASP1177F, ASP1183F, ASP249A, ASP265A, ASP348A, ASP363A, ASP373A, ASP379A, ASP380A, CYS258A, CYS354A, GLN1163F, GLN1164F, GLN1168F, GLN1190F, GLN172A, GLN262A, GLN307A, GLN352A, GLN359A, GLU1140F, GLU1143F, GLU1158F, GLU1167F, GLU1175F, GLU1178F, GLU1187F, GLU264A, GLU268A, GLU317A, GLU318A, GLU347A, GLU358A, GLU362A, GLU377A, GLU383A, GLY1176F, GLY1180F, GLY1192F, GLY221A, GLY304A, ILE1170F, ILE222A, ILE248A, ILE259A, ILE309A, ILE313A, ILE374A, LEU1160F, LEU1169F, LEU1185F, LEU1186F, LEU1189F, LEU163A, LEU212A, LEU226A, LEU235A, LEU253A, LEU254A, LEU257A, LEU260A, LEU306A, LEU308A, LEU312A, LYS1137F, LYS1144F, LYS1154F, LYS1162F, LYS1165F, LYS213A, LYS219A, LYS223A, LYS252A, MET1145F, MET1172F, MET1182F, MET216A, MET225A, MET266A, MET349A, MET376A, MET378A, PHE1195F, PHE215A, PHE220A, PHE356A, PHE365A, PRO167A, PRO261A, PRO263A, PRO315A, SER1184F, SER1191F, SER169A, SER255A, THR1141F, THR1179F, THR224A, THR314A, TRP170A, VAL1181F, VAL168A, VAL171A, VAL303A, VAL351A, VAL355A
• A-C: ARG342C, ARG446A, ARG446C, ASP442C, CYS445A, CYS445C, GLN336A, GLN336C, GLN449A, GLN449C, GLU340A, GLU340C, GLU343A, GLU343C, GLU345A, GLU345C, GLY296A, GLY296C, GLY333A, GLY333C, HIS335A, HIS335C, HIS447A, HIS447C, ILE299A, ILE299C, ILE344A, ILE344C, LEU341A, LEU341C, LEU448A, LEU448C, LYS294A, LYS294C, LYS302A, LYS302C, LYS444A, LYS444C, PHE443C, SER295A, SER295C, SER298A, THR297A, THR297C
• A-D: ALA242A, ALA300A, ARG342D, ARG454D, ASN245A, ASN346A, ASP348A, ASP451D, ASP457D, GLN339D, GLN449D, GLU340A, GLU343A, GLU343D, GLU345A, GLU347A, GLU453D, GLY296A, HIS206A, HIS335D, ILE248A, ILE299A, ILE344A, ILE450D, ILE452D, LEU293A, LEU301A, LEU341A, LEU448D, LEU455D, LYS294A, LYS302A, LYS350A, LYS436D, MET246A, MET349A, PRO241A, PRO244A, SER295A, SER298A, THR297A, VAL243A, VAL303A, VAL351A, VAL456D
• E-B: ALA1148E, ALA1151E, ALA1155E, ALA1174E, ALA1188E, ALA1193E, ALA1194E, ALA214B, ALA250B, ALA251B, ALA256B, ALA311B, ALA316B, ARG1147E, ARG1159E, ARG1166E, ARG322B, ARG375B, ASN1173E, ASN164B, ASN165B, ASN166B, ASN217B, ASN218B, ASN267B, ASN310B, ASP1171E, ASP1177E, ASP1183E, ASP249B, ASP265B, ASP348B, ASP363B, ASP366B, ASP372B, ASP373B, ASP379B, ASP380B, CYS258B, CYS354B, GLN1163E, GLN1164E, GLN1168E, GLN1190E, GLN172B, GLN262B, GLN307B, GLN352B, GLN359B, GLU1140E, GLU1143E, GLU1158E, GLU1167E, GLU1175E, GLU1178E, GLU1187E, GLU264B, GLU268B, GLU317B, GLU318B, GLU347B, GLU358B, GLU362B, GLU377B, GLU383B, GLY1176E, GLY1180E, GLY1192E, GLY221B, GLY304B, ILE1170E, ILE222B, ILE248B, ILE259B, ILE309B, ILE313B, ILE374B, ILE387B, LEU1160E, LEU1169E, LEU1185E, LEU1186E, LEU1189E, LEU163B, LEU212B, LEU226B, LEU235B, LEU253B, LEU254B, LEU257B, LEU260B, LEU306B, LEU308B, LEU312B, LEU319B, LYS1137E, LYS1144E, LYS1162E, LYS1165E, LYS213B, LYS219B, LYS223B, LYS252B, MET1145E, MET1172E, MET1182E, MET216B, MET225B, MET266B, MET349B, MET376B, MET378B, PHE1195E, PHE215B, PHE220B, PHE356B, PRO167B, PRO261B, PRO263B, PRO315B, SER1184E, SER1191E, SER169B, SER255B, THR1179E, THR224B, THR314B, VAL1181E, VAL168B, VAL171B, VAL303B, VAL351B, VAL355B
• E-F: ALA772E, ALA772F, ALA796E, ALA796F, ALA801E, ALA801F, ALA804E, ALA804F, ALA972E, ALA972F, ALA977E, ALA977F, ALA979E, ALA979F, ALA996E, ALA996F, ARG763E, ARG763F, ARG764E, ARG764F, ARG788E, ARG788F, ARG951E, ARG951F, ARG975E, ARG975F, ARG991E, ARG991F, ASN1012E, ASN1012F, ASN766E, ASN766F, ASN791E, ASN791F, ASN792E, ASN792F, ASN955E, ASN955F, ASN968E, ASN968F, ASN971E, ASN971F, ASN976E, ASN976F, ASN983E, ASN983F, ASP1013E, ASP1013F, ASP1103E, ASP1103F, ASP1108F, ASP774E, ASP774F, ASP778E, ASP778F, ASP787E, ASP787F, ASP992E, ASP992F, ASP997E, ASP997F, CYS1010E, CYS1010F, CYS779E, CYS779F, GLN761E, GLN761F, GLN777E, GLN777F, GLN805E, GLN805F, GLN998E, GLN998F, GLU1008E, GLU1008F, GLU1016E, GLU1016F, GLU1100E, GLU1100F, GLU759E, GLU759F, GLU773E, GLU773F, GLU786E, GLU786F, GLU790E, GLU790F, GLU793E, GLU793F, GLU954E, GLU954F, GLU961E, GLU961F, GLY1102E, GLY1102F, GLY967E, GLY967F, GLY973E, GLY973F, GLY978E, GLY978F, GLY981E, GLY981F, HIS1004E, HIS1004F, HIS1014E, HIS1014F, ILE984E, ILE984F, LEU1002E, LEU1002F, LEU1003E, LEU1003F, LEU1006E, LEU1006F, LEU1009E, LEU1009F, LEU1101E, LEU1101F, LEU762E, LEU762F, LEU775E, LEU775F, LEU794E, LEU794F, LEU798E, LEU798F, LEU800E, LEU800F, LEU959E, LEU959F, LEU960E, LEU960F, LEU962E, LEU962F, LEU964E, LEU964F, LEU965E, LEU965F, LEU987E, LEU987F, LEU990E, LEU990F, LYS1099E, LYS1099F, LYS754E, LYS754F, LYS757E, LYS757F, LYS769E, LYS769F, LYS783E, LYS783F, LYS785E, LYS785F, LYS797E, LYS797F, LYS989E, LYS989F, LYS994E, LYS994F, LYS999E, LYS999F, MET1000E, MET1000F, MET970E, MET970F, PHE1005E, PHE1005F, PHE1105E, PHE1105F, PHE1107E, PHE1107F, PHE770E, PHE770F, PHE780E, PHE780F, PHE789E, PHE789F, PHE795E, PHE795F, PHE802E, PHE802F, PHE956E, PHE956F, PHE980E, PHE980F, PHE982E, PHE982F, PHE986E, PHE986F, PRO758E, PRO758F, PRO765E, PRO765F, SER768E, SER768F, SER776E, SER776F, SER803E, SER803F, SER953E, SER953F, SER957E, SER957F, SER958E, SER958F, SER974E, SER974F, SER985E, SER985F, SER995E, SER995F, THR1001E, THR1001F, THR782E, THR782F, THR799E, THR799F, THR963E, THR963F, THR993E, THR993F, TRP767E, TRP767F, TRP781E, TRP781F, TYR1104E, TYR1104F, TYR756E, TYR756F, TYR969E, TYR969F, VAL1017E, VAL1017F, VAL1106E, VAL1106F, VAL755E, VAL755F, VAL760E, VAL760F, VAL771E, VAL771F, VAL784E, VAL784F, VAL966E, VAL966F
• B-C: ALA242C, ALA300C, ARG342B, ARG454B, ASN245C, ASN346C, ASP348C, ASP451B, ASP457B, GLN339B, GLN449B, GLU340C, GLU343B, GLU343C, GLU345C, GLU347C, GLU453B, GLY292C, GLY296C, HIS206C, HIS335B, ILE248C, ILE299C, ILE344C, ILE450B, ILE452B, LEU293C, LEU301C, LEU341C, LEU448B, LEU455B, LYS294C, LYS302C, LYS350C, LYS436B, MET246C, PRO241C, PRO244C, SER295C, SER298C, THR297C, VAL243C, VAL351C, VAL456B
• C-D: ALA397C, ALA397D, ALA417C, ALA417D, ARG322C, ARG322D, ARG326C, ARG326D, ARG331C, ARG331D, ARG370C, ARG370D, ARG375C, ARG375D, ARG412C, ARG412D, ARG418C, ARG418D, ARG446C, ARG446D, ARG454D, ASN390C, ASN390D, ASN413C, ASN413D, ASP320C, ASP320D, ASP366C, ASP366D, ASP372C, ASP372D, ASP373C, ASP373D, ASP379C, ASP379D, ASP380C, ASP380D, ASP394C, ASP394D, ASP414C, ASP414D, ASP440C, ASP440D, ASP442C, ASP442D, ASP451C, ASP451D, CYS428C, CYS428D, CYS445C, CYS445D, GLN386C, GLN386D, GLN406C, GLN406D, GLN420C, GLN420D, GLN431C, GLN431D, GLN449C, GLN449D, GLU328C, GLU328D, GLU377C, GLU377D, GLU383C, GLU383D, GLU398C, GLU398D, GLU416C, GLU416D, GLU426C, GLU426D, GLU427C, GLU427D, GLU453D, GLY369C, GLY369D, GLY382C, GLY382D, GLY438C, GLY438D, HIS324C, HIS324D, HIS400C, HIS400D, HIS407C, HIS407D, HIS435C, HIS435D, HIS447C, HIS447D, ILE325C, ILE325D, ILE374C, ILE374D, ILE387C, ILE387D, ILE388C, ILE388D, ILE404C, ILE404D, ILE425C, ILE425D, ILE432C, ILE432D, ILE450C, ILE450D, ILE452C, ILE452D, LEU319C, LEU319D, LEU367C, LEU367D, LEU371C, LEU371D, LEU389C, LEU389D, LEU402C, LEU402D, LEU405C, LEU405D, LEU408C, LEU408D, LEU409C, LEU409D, LEU410C, LEU410D, LEU424C, LEU424D, LEU434C, LEU434D, LEU448C, LEU448D, LYS368C, LYS368D, LYS393C, LYS393D, LYS396C, LYS396D, LYS423C, LYS423D, LYS444C, LYS444D, MET376C, MET376D, MET378C, MET378D, PHE321C, PHE321D, PHE364C, PHE364D, PHE381C, PHE381D, PHE385C, PHE385D, PHE401C, PHE401D, PHE443C, PHE443D, PRO399C, PRO399D, PRO419C, PRO419D, PRO441C, PRO441D, SER327C, SER327D, SER395C, SER395D, SER403C, SER403D, SER430C, SER430D, THR391C, THR391D, THR439C, THR439D, TYR415C, TYR415D, TYR421C, TYR421D, TYR422C, TYR422D, VAL323C, VAL323D, VAL384C, VAL384D, VAL392C, VAL392D, VAL411C, VAL411D, VAL429C, VAL429D, VAL433C, VAL433D
• C-H: ALA1148H, ALA1151H, ALA1155H, ALA1174H, ALA1188H, ALA1193H, ALA1194H, ALA214C, ALA251C, ALA256C, ALA300C, ALA311C, ALA316C, ARG1147H, ARG1159H, ARG1166H, ARG1196H, ARG322C, ARG375C, ASN1173H, ASN164C, ASN165C, ASN166C, ASN217C, ASN218C, ASN267C, ASN310C, ASN346C, ASP1171H, ASP1177H, ASP1183H, ASP249C, ASP265C, ASP348C, ASP363C, ASP373C, ASP379C, ASP380C, CYS258C, CYS354C, GLN1163H, GLN1164H, GLN1168H, GLN1190H, GLN172C, GLN262C, GLN307C, GLN352C, GLN359C, GLU1140H, GLU1143H, GLU1158H, GLU1167H, GLU1175H, GLU1178H, GLU1187H, GLU264C, GLU268C, GLU317C, GLU318C, GLU347C, GLU358C, GLU362C, GLU377C, GLU383C, GLY1176H, GLY1180H, GLY1192H, GLY221C, GLY304C, ILE1170H, ILE222C, ILE248C, ILE259C, ILE309C, ILE313C, ILE374C, LEU1160H, LEU1169H, LEU1185H, LEU1186H, LEU1189H, LEU163C, LEU212C, LEU226C, LEU235C, LEU253C, LEU254C, LEU257C, LEU260C, LEU306C, LEU308C, LEU312C, LYS1137H, LYS1144H, LYS1154H, LYS1162H, LYS1165H, LYS213C, LYS219C, LYS223C, LYS252C, MET1145H, MET1172H, MET1182H, MET216C, MET225C, MET266C, MET349C, MET376C, MET378C, PHE1195H, PHE215C, PHE220C, PHE356C, PHE365C, PRO167C, PRO261C, PRO263C, PRO315C, SER1184H, SER1191H, SER169C, SER255C, THR1141H, THR1179H, THR224C, THR314C, TRP170C, VAL1181H, VAL168C, VAL171C, VAL303C, VAL351C, VAL355C
• G-D: ALA1148G, ALA1151G, ALA1155G, ALA1174G, ALA1188G, ALA1193G, ALA1194G, ALA214D, ALA251D, ALA256D, ALA311D, ALA316D, ARG1147G, ARG1159G, ARG1166G, ARG1196G, ARG322D, ARG375D, ASN1173G, ASN164D, ASN165D, ASN166D, ASN217D, ASN218D, ASN267D, ASN310D, ASP1171G, ASP1177G, ASP1183G, ASP249D, ASP265D, ASP348D, ASP363D, ASP366D, ASP372D, ASP373D, ASP379D, ASP380D, CYS258D, CYS354D, GLN1163G, GLN1164G, GLN1168G, GLN1190G, GLN172D, GLN262D, GLN307D, GLN352D, GLN359D, GLU1140G, GLU1143G, GLU1158G, GLU1167G, GLU1175G, GLU1178G, GLU1187G, GLU264D, GLU268D, GLU317D, GLU318D, GLU347D, GLU358D, GLU362D, GLU377D, GLU383D, GLY1176G, GLY1180G, GLY1192G, GLY221D, GLY304D, ILE1170G, ILE222D, ILE248D, ILE259D, ILE309D, ILE313D, ILE387D, LEU1160G, LEU1169G, LEU1185G, LEU1186G, LEU1189G, LEU163D, LEU212D, LEU226D, LEU235D, LEU253D, LEU254D, LEU257D, LEU260D, LEU306D, LEU308D, LEU312D, LEU319D, LYS1137G, LYS1144G, LYS1162G, LYS1165G, LYS213D, LYS219D, LYS223D, LYS252D, MET1145G, MET1172G, MET1182G, MET216D, MET225D, MET266D, MET349D, MET376D, MET378D, PHE1195G, PHE215D, PHE220D, PHE356D, PRO167D, PRO261D, PRO263D, PRO315D, SER1184G, SER1191G, SER169D, SER255D, THR1179G, THR224D, THR314D, VAL1181G, VAL168D, VAL171D, VAL303D, VAL351D, VAL355D
• G-H: ALA1007G, ALA772G, ALA772H, ALA796G, ALA796H, ALA801G, ALA801H, ALA804G, ALA804H, ALA972G, ALA972H, ALA977G, ALA977H, ALA979G, ALA979H, ALA996G, ALA996H, ARG763G, ARG763H, ARG764G, ARG764H, ARG788G, ARG788H, ARG951G, ARG951H, ARG975G, ARG975H, ARG991G, ASN1012G, ASN1012H, ASN766G, ASN766H, ASN791G, ASN791H, ASN792G, ASN792H, ASN955G, ASN955H, ASN968G, ASN968H, ASN971G, ASN971H, ASN976G, ASN976H, ASN983G, ASN983H, ASP1013G, ASP1013H, ASP1103G, ASP1103H, ASP1108H, ASP774G, ASP774H, ASP778G, ASP778H, ASP787G, ASP787H, ASP992G, ASP992H, ASP997G, ASP997H, CYS1010G, CYS1010H, CYS779G, CYS779H, GLN761G, GLN761H, GLN777G, GLN777H, GLN805G, GLN998G, GLN998H, GLU1008G, GLU1008H, GLU1016G, GLU1016H, GLU1100G, GLU1100H, GLU759G, GLU759H, GLU773G, GLU773H, GLU786G, GLU786H, GLU790G, GLU790H, GLU793G, GLU793H, GLU954G, GLU954H, GLU961G, GLU961H, GLY1102G, GLY1102H, GLY967G, GLY967H, GLY973G, GLY973H, GLY978G, GLY978H, GLY981G, GLY981H, HIS1004G, HIS1004H, HIS1014G, HIS1014H, ILE984G, ILE984H, LEU1002G, LEU1002H, LEU1003G, LEU1003H, LEU1006G, LEU1006H, LEU1009G, LEU1009H, LEU1101G, LEU1101H, LEU762G, LEU762H, LEU775G, LEU775H, LEU794G, LEU794H, LEU798G, LEU798H, LEU800G, LEU800H, LEU959G, LEU959H, LEU960G, LEU960H, LEU962G, LEU962H, LEU964G, LEU964H, LEU965G, LEU965H, LEU987G, LEU987H, LEU990G, LEU990H, LYS1099G, LYS1099H, LYS753H, LYS754G, LYS754H, LYS757G, LYS757H, LYS769G, LYS769H, LYS783G, LYS783H, LYS785G, LYS785H, LYS797G, LYS797H, LYS989G, LYS989H, LYS994G, LYS994H, LYS999G, LYS999H, MET1000G, MET1000H, MET970G, MET970H, PHE1005G, PHE1005H, PHE1105G, PHE1105H, PHE1107G, PHE1107H, PHE770G, PHE770H, PHE780G, PHE780H, PHE789G, PHE789H, PHE795G, PHE795H, PHE802G, PHE802H, PHE956G, PHE956H, PHE980G, PHE980H, PHE982G, PHE982H, PHE986G, PHE986H, PRO758G, PRO758H, PRO765G, PRO765H, SER768G, SER768H, SER776G, SER776H, SER803G, SER803H, SER953G, SER953H, SER957G, SER957H, SER958G, SER958H, SER974G, SER974H, SER985G, SER985H, SER995G, SER995H, THR1001G, THR1001H, THR782G, THR782H, THR799G, THR799H, THR963G, THR963H, THR993G, THR993H, TRP767G, TRP767H, TRP781G, TRP781H, TYR1104G, TYR1104H, TYR756G, TYR756H, TYR969G, TYR969H, VAL1017G, VAL1017H, VAL1106G, VAL1106H, VAL755G, VAL755H, VAL760G, VAL760H, VAL771G, VAL771H, VAL784G, VAL784H, VAL966G, VAL966H