3OBK

crystal structure of delta-aminolevulinic acid dehydratase (porphobilinogen synthase) from toxoplasma gondii me49 in complex with the reaction product porphobilinogen

• Total interactions analyzed: 28
• Total true interactions: 16
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 314
  • Norm. En. per Res.: -5.3918
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-238.798	-281.0014	-1071.39	-1591.1893	313	58	23	40382	22	161	137
A-C	-281.9013	-107.16	-847.209	-1236.2703	264	42	18	33045	2	102	60
A-D	-15.0202	-21.706	-63.7366	-100.4628	48	2	0	2650	5	30	26
A-E	-8.2384	-18.6626	-67.3853	-94.2863	49	2	0	2715	4	30	27
B-C	-3.2625	-22.6161	-70.5439	-96.4225	49	1	0	2668	5	29	25
B-E	-286.8255	-102.4311	-857.52	-1246.7766	261	54	20	33085	2	103	62
B-F	-4.6908	-14.3183	-66.0658	-85.0749	47	1	0	2637	5	30	26
C-D	-282.4365	-313.7588	-1096.82	-1693.0153	314	49	24	39809	22	160	135
C-H	-3.5231	-11.3459	-59.4747	-74.3437	50	5	0	2584	4	30	27
D-G	-13.6123	-22.2321	-72.4813	-108.3257	52	3	0	2717	3	30	27
D-H	-264.4507	-104.5806	-865.842	-1234.8733	262	39	19	33179	2	104	62
E-F	-228.0889	-295.3007	-1072.7	-1596.0896	314	52	22	39803	21	162	135
E-G	-21.6397	-36.136	-70.3631	-128.1388	51	3	0	2821	7	28	27
F-G	-256.6512	-108.184	-841.716	-1206.5513	262	37	19	32922	2	104	58
F-H	-5.5506	-3.2304	-43.5124	-52.2935	46	3	0	2090	4	29	27
G-H	-267.8154	-285.1058	-1063.93	-1616.8512	318	52	25	39381	20	161	137

Interface residues

• A-B: ALA192A, ALA192B, ALA215A, ALA215B, ALA21A, ALA21B, ALA249A, ALA249B, ALA255A, ALA255B, ALA277A, ALA277B, ALA297A, ALA297B, ALA301A, ALA301B, ALA302A, ALA302B, ALA303A, ALA303B, ALA324A, ALA324B, ARG189A, ARG189B, ARG194A, ARG194B, ARG22A, ARG22B, ARG247A, ARG247B, ARG24A, ARG24B, ARG251A, ARG251B, ARG25A, ARG25B, ARG27A, ARG27B, ARG280B, ARG30A, ARG30B, ARG322A, ARG322B, ARG323A, ARG323B, ARG33A, ARG33B, ASN10A, ASN10B, ASN158A, ASN158B, ASN245A, ASN245B, ASN26A, ASN26B, ASN29A, ASN29B, ASN39A, ASN39B, ASP146A, ASP159A, ASP159B, ASP184A, ASP184B, ASP187A, ASP187B, ASP224A, ASP224B, ASP235A, ASP235B, ASP242A, ASP242B, ASP256A, ASP274A, ASP274B, ASP312A, ASP312B, ASP8A, ASP8B, CYS166A, CYS166B, CYS212A, CYS212B, GLN164A, GLN164B, GLN20A, GLN20B, GLN240A, GLN240B, GLN34A, GLN34B, GLN37A, GLN37B, GLU14A, GLU14B, GLU195A, GLU195B, GLU248A, GLU248B, GLU250A, GLU250B, GLU252A, GLU252B, GLU259A, GLU259B, GLU281A, GLU281B, GLU295A, GLU295B, GLU304A, GLU304B, GLU310A, GLU310B, GLU316A, GLU316B, GLU38A, GLU38B, GLY147A, GLY147B, GLY154B, GLY188A, GLY188B, GLY220A, GLY220B, GLY269A, GLY269B, GLY294A, GLY294B, GLY306A, GLY306B, GLY325A, GLY325B, GLY5A, GLY5B, GLY66B, HIS145A, HIS163A, HIS163B, HIS229A, HIS229B, HIS291A, HIS291B, ILE156A, ILE156B, ILE193A, ILE193B, ILE19A, ILE19B, ILE308A, ILE308B, ILE61A, ILE61B, LEU160A, LEU160B, LEU165A, LEU165B, LEU17A, LEU17B, LEU197A, LEU270A, LEU270B, LEU273A, LEU273B, LEU276A, LEU276B, LEU299A, LEU299B, LEU315A, LEU315B, LEU318A, LEU318B, LEU35A, LEU35B, LEU40A, LEU40B, LEU7A, LEU7B, LYS155A, LYS155B, LYS167A, LYS167B, LYS213A, LYS213B, LYS236A, LYS236B, LYS237A, LYS237B, LYS278A, LYS278B, LYS282A, LYS282B, LYS28A, LYS28B, LYS300A, LYS300B, LYS305A, LYS305B, LYS311A, LYS311B, LYS319A, LYS319B, LYS350A, LYS350B, MET104A, MET185A, MET185B, MET186A, MET186B, MET199A, MET199B, MET241A, MET241B, MET298A, MET298B, MET64A, MET64B, PHE218A, PHE218B, PHE222A, PHE222B, PHE321A, PHE321B, PHE351A, PHE351B, PRO18A, PRO18B, PRO221A, PRO221B, PRO23A, PRO23B, PRO243A, PRO243B, PRO268A, PRO268B, PRO271A, PRO271B, PRO62A, PRO62B, PRO65A, PRO65B, PRO6A, PRO6B, SER191A, SER191B, SER196A, SER196B, SER211A, SER211B, SER216A, SER216B, SER217A, SER217B, SER244A, SER244B, SER246A, SER246B, SER293A, SER293B, SER309A, SER309B, SER320A, SER320B, SER63A, SER63B, THR161A, THR161B, THR238A, THR238B, THR313A, THR313B, TRP16A, TRP16B, TYR214A, TYR214B, TYR219A, TYR219B, TYR239A, TYR239B, TYR272A, TYR272B, TYR296A, TYR296B, TYR307A, TYR307B, TYR333A, TYR333B, VAL148A, VAL148B, VAL149B, VAL157A, VAL157B, VAL15A, VAL15B, VAL162A, VAL162B, VAL190A, VAL190B, VAL266A, VAL266B, VAL275A, VAL275B, VAL292A, VAL292B, VAL314A, VAL314B, VAL317A, VAL317B, VAL32A, VAL32B, VAL36A, VAL36B, VAL41A, VAL41B
• A-C: ALA177A, ALA177C, ALA192A, ALA192C, ALA21A, ALA21C, ALA255A, ALA255C, ALA257A, ALA257C, ALA261A, ALA261C, ALA31A, ALA31C, ALA326A, ALA326C, ALA328A, ALA328C, ALA330A, ALA330C, ALA337A, ALA337C, ALA338A, ALA338C, ALA89A, ALA89C, ARG174A, ARG174C, ARG194A, ARG194C, ARG22A, ARG22C, ARG24A, ARG24C, ARG25A, ARG25C, ARG27A, ARG27C, ARG280A, ARG280C, ARG30A, ARG30C, ARG322A, ARG322C, ARG33A, ARG33C, ARG83A, ARG83C, ASN10A, ASN10C, ASN11A, ASN11C, ASN26A, ASN26C, ASN29A, ASN29C, ASN39A, ASN39C, ASN9A, ASN9C, ASP128A, ASP128C, ASP178A, ASP178C, ASP198A, ASP198C, ASP204A, ASP204C, ASP256A, ASP256C, ASP262A, ASP262C, ASP312A, ASP312C, ASP327A, ASP327C, ASP344A, ASP344C, ASP8A, ASP8C, CYS202A, CYS202C, CYS355A, CYS355C, GLN20A, GLN20C, GLN349A, GLN349C, GLN34A, GLN34C, GLN37A, GLN37C, GLU14A, GLU14C, GLU195A, GLU195C, GLU200A, GLU200C, GLU259A, GLU259C, GLU316A, GLU316C, GLU343A, GLU343C, GLU353A, GLU353C, GLU38A, GLU38C, GLY13A, GLY13C, GLY176C, GLY201A, GLY201C, GLY260A, GLY260C, GLY347A, GLY86A, GLY86C, ILE170A, ILE170C, ILE193A, ILE193C, ILE19A, ILE19C, ILE207A, ILE207C, ILE47A, ILE47C, ILE87A, ILE87C, LEU130A, LEU130C, LEU131A, LEU131C, LEU132A, LEU132C, LEU17A, LEU17C, LEU197A, LEU197C, LEU208A, LEU208C, LEU264A, LEU264C, LEU285A, LEU285C, LEU315A, LEU315C, LEU318A, LEU318C, LEU35A, LEU35C, LEU40A, LEU40C, LEU46A, LEU46C, LYS123A, LYS284A, LYS284C, LYS28A, LYS28C, LYS311A, LYS311C, LYS319A, LYS319C, LYS339A, LYS346A, LYS346C, LYS350A, LYS350C, LYS42A, LYS42C, LYS88A, LYS88C, MET179A, MET179C, MET199A, MET199C, MET263A, MET263C, MET287A, MET287C, MET341A, MET341C, MET345A, MET345C, MET91A, MET91C, PHE321A, PHE351A, PHE351C, PHE90A, PHE90C, PRO127A, PRO127C, PRO18A, PRO18C, PRO23A, PRO23C, PRO286A, PRO286C, PRO354A, PRO354C, PRO43A, PRO43C, SER191A, SER191C, SER196A, SER196C, SER206A, SER206C, SER258A, SER258C, SER320A, SER320C, SER44A, SER44C, SER45A, SER45C, SER84A, SER84C, THR203A, THR203C, THR205A, THR205C, THR313A, THR352A, THR352C, TRP16A, TRP16C, TRP340A, TRP340C, TYR12A, TYR12C, TYR356A, TYR356C, TYR48A, TYR48C, TYR85A, TYR85C, VAL129A, VAL129C, VAL15A, VAL15C, VAL180A, VAL180C, VAL190A, VAL190C, VAL288A, VAL288C, VAL314A, VAL314C, VAL317A, VAL317C, VAL329A, VAL329C, VAL32A, VAL32C, VAL342A, VAL342C, VAL36A, VAL36C, VAL41A, VAL41C
• A-D: ALA249D, ALA257A, ALA261A, ALA326A, ARG247D, ARG251D, ARG280A, ARG322A, ASN11A, ASN158D, ASN245D, ASP159D, ASP198A, ASP204A, ASP262A, ASP327A, GLN20A, GLU248D, GLU250D, GLU252D, GLU254D, GLU281A, GLY260A, GLY325A, GLY5D, ILE279A, ILE279D, LEU264A, LEU285A, LYS155D, LYS282A, LYS282D, LYS284A, MET263A, MET287A, PRO243D, PRO286A, PRO6D, SER153D, SER244D, SER246D, SER283A, THR203A, THR205A, TRP16A, TYR356A, VAL157D, VAL288A
• A-E: ALA249A, ALA257E, ALA261E, ALA326E, ARG247A, ARG251A, ARG280E, ARG322E, ASN158A, ASN245A, ASP159A, ASP198E, ASP204E, ASP242A, ASP262E, ASP327E, CYS202E, GLN20E, GLU248A, GLU250A, GLU252A, GLU254A, GLU281E, GLY260E, GLY325E, GLY5A, ILE279A, ILE279E, LEU264E, LEU285E, LYS155A, LYS278A, LYS282A, LYS282E, LYS284E, MET263E, MET287E, PRO243A, PRO286E, PRO6A, SER244A, SER246A, SER283E, THR203E, THR205E, TRP16E, TYR356E, VAL157A, VAL288E
• B-C: ALA249B, ALA253B, ALA257C, ALA261C, ALA326C, ARG247B, ARG251B, ARG280C, ARG322C, ASN11C, ASN158B, ASN245B, ASP159B, ASP198C, ASP204C, ASP262C, ASP327C, GLN20C, GLU248B, GLU250B, GLU252B, GLU254B, GLU281C, GLY260C, GLY325C, GLY5B, ILE156B, ILE279B, ILE279C, LEU264C, LEU285C, LYS155B, LYS278B, LYS282B, LYS284C, MET263C, MET287C, PRO243B, PRO286C, PRO6B, SER153B, SER244B, SER246B, SER283C, THR203C, TRP16C, TYR356C, VAL157B, VAL288C
• B-E: ALA177B, ALA177E, ALA192B, ALA192E, ALA21B, ALA21E, ALA255B, ALA255E, ALA257B, ALA257E, ALA261B, ALA261E, ALA31B, ALA31E, ALA326B, ALA326E, ALA328B, ALA328E, ALA330E, ALA337B, ALA337E, ALA338B, ALA338E, ALA89B, ALA89E, ARG174B, ARG174E, ARG194B, ARG194E, ARG22B, ARG22E, ARG24B, ARG24E, ARG25B, ARG25E, ARG27B, ARG27E, ARG280B, ARG280E, ARG30B, ARG30E, ARG322B, ARG322E, ARG33B, ARG33E, ARG83B, ARG83E, ASN10B, ASN10E, ASN11B, ASN11E, ASN26B, ASN26E, ASN29B, ASN29E, ASN39B, ASN39E, ASN9B, ASN9E, ASP128B, ASP128E, ASP178B, ASP178E, ASP198B, ASP198E, ASP204B, ASP204E, ASP256B, ASP256E, ASP262B, ASP262E, ASP312B, ASP312E, ASP327B, ASP327E, ASP344B, ASP344E, ASP8B, ASP8E, CYS202B, CYS202E, CYS355B, CYS355E, GLN20B, GLN20E, GLN349B, GLN349E, GLN34B, GLN34E, GLN37B, GLN37E, GLU14B, GLU14E, GLU195B, GLU195E, GLU200B, GLU200E, GLU259B, GLU259E, GLU316B, GLU316E, GLU343B, GLU343E, GLU353B, GLU353E, GLU38B, GLU38E, GLY13B, GLY13E, GLY176B, GLY201B, GLY201E, GLY260B, GLY260E, GLY86B, GLY86E, ILE170B, ILE170E, ILE193B, ILE19B, ILE19E, ILE207B, ILE207E, ILE47B, ILE47E, ILE87B, ILE87E, LEU130B, LEU130E, LEU131B, LEU131E, LEU132B, LEU132E, LEU17B, LEU17E, LEU197B, LEU197E, LEU208B, LEU208E, LEU264B, LEU264E, LEU285B, LEU285E, LEU315B, LEU315E, LEU318B, LEU318E, LEU35B, LEU35E, LEU40B, LEU40E, LEU46B, LEU46E, LYS123B, LYS123E, LYS284B, LYS284E, LYS28B, LYS28E, LYS311B, LYS311E, LYS319B, LYS319E, LYS346B, LYS346E, LYS350B, LYS350E, LYS42B, LYS42E, LYS88B, LYS88E, MET179B, MET179E, MET199B, MET199E, MET263B, MET263E, MET287B, MET287E, MET341B, MET341E, MET345B, MET345E, MET91B, MET91E, PHE351B, PHE351E, PHE90B, PHE90E, PRO127B, PRO127E, PRO18B, PRO18E, PRO23B, PRO23E, PRO286B, PRO286E, PRO354B, PRO354E, PRO43B, PRO43E, SER191B, SER191E, SER196B, SER196E, SER206B, SER206E, SER258B, SER258E, SER320B, SER320E, SER44B, SER44E, SER45B, SER45E, SER84B, SER84E, THR203B, THR203E, THR205B, THR205E, THR313B, THR313E, THR352B, THR352E, TRP16B, TRP16E, TRP340B, TRP340E, TYR12B, TYR12E, TYR356B, TYR356E, TYR48B, TYR48E, TYR85B, TYR85E, VAL129B, VAL129E, VAL15B, VAL15E, VAL180B, VAL180E, VAL190B, VAL190E, VAL288B, VAL288E, VAL314B, VAL314E, VAL317B, VAL317E, VAL329B, VAL329E, VAL32B, VAL32E, VAL342B, VAL342E, VAL36B, VAL36E, VAL41B, VAL41E
• B-F: ALA249F, ALA257B, ALA261B, ALA326B, ARG247F, ARG251F, ARG280B, ARG322B, ASN158F, ASN245F, ASP159F, ASP198B, ASP204B, ASP242F, ASP262B, ASP327B, GLN20B, GLU248F, GLU250F, GLU252F, GLU254F, GLU281B, GLY260B, GLY325B, GLY5F, ILE279B, LEU264B, LEU285B, LYS155F, LYS278F, LYS282B, LYS282F, LYS284B, MET263B, MET287B, PRO243F, PRO286B, PRO6F, SER153F, SER244F, SER246F, SER283B, THR203B, TRP16B, TYR356B, VAL157F, VAL288B
• C-D: ALA192C, ALA192D, ALA215C, ALA215D, ALA21C, ALA21D, ALA249C, ALA249D, ALA255C, ALA255D, ALA277C, ALA277D, ALA297C, ALA297D, ALA301C, ALA301D, ALA302C, ALA302D, ALA303C, ALA303D, ALA324C, ALA324D, ARG189C, ARG189D, ARG194C, ARG194D, ARG22C, ARG22D, ARG247C, ARG247D, ARG24C, ARG24D, ARG251C, ARG251D, ARG25C, ARG25D, ARG27C, ARG27D, ARG280C, ARG30C, ARG30D, ARG322C, ARG322D, ARG323C, ARG323D, ARG33C, ARG33D, ASN10C, ASN10D, ASN158C, ASN158D, ASN245C, ASN245D, ASN26C, ASN26D, ASN29C, ASN29D, ASN39C, ASN39D, ASN9D, ASP146C, ASP159C, ASP159D, ASP184C, ASP184D, ASP187C, ASP187D, ASP224C, ASP224D, ASP235C, ASP235D, ASP242C, ASP242D, ASP256C, ASP274C, ASP274D, ASP312C, ASP312D, ASP8C, ASP8D, CYS166C, CYS166D, CYS212C, CYS212D, GLN164C, GLN164D, GLN20C, GLN20D, GLN240C, GLN240D, GLN34C, GLN34D, GLN37C, GLN37D, GLU14C, GLU14D, GLU195C, GLU195D, GLU248C, GLU248D, GLU250C, GLU250D, GLU252C, GLU252D, GLU259C, GLU259D, GLU281C, GLU281D, GLU295C, GLU295D, GLU304C, GLU304D, GLU310C, GLU310D, GLU316C, GLU316D, GLU38C, GLU38D, GLY147C, GLY147D, GLY154C, GLY154D, GLY188C, GLY188D, GLY220C, GLY220D, GLY269C, GLY269D, GLY294C, GLY294D, GLY306C, GLY306D, GLY325C, GLY325D, GLY5C, GLY5D, HIS145D, HIS163C, HIS163D, HIS229C, HIS229D, HIS291C, HIS291D, ILE156C, ILE156D, ILE170C, ILE193C, ILE193D, ILE19C, ILE19D, ILE308C, ILE308D, ILE61C, ILE61D, LEU160C, LEU160D, LEU165C, LEU17C, LEU17D, LEU197C, LEU197D, LEU270C, LEU270D, LEU273C, LEU273D, LEU276C, LEU276D, LEU299C, LEU299D, LEU315C, LEU315D, LEU318C, LEU318D, LEU35C, LEU35D, LEU40C, LEU40D, LEU7C, LEU7D, LYS155C, LYS155D, LYS167C, LYS167D, LYS213C, LYS213D, LYS236C, LYS236D, LYS237C, LYS237D, LYS278C, LYS278D, LYS282D, LYS28C, LYS28D, LYS300C, LYS300D, LYS305C, LYS305D, LYS311C, LYS311D, LYS319C, LYS319D, LYS350C, LYS350D, MET104D, MET185C, MET185D, MET186C, MET186D, MET199C, MET199D, MET241C, MET241D, MET298C, MET298D, MET64C, MET64D, PHE218C, PHE218D, PHE222C, PHE222D, PHE321C, PHE321D, PHE351C, PHE351D, PRO18C, PRO18D, PRO221C, PRO221D, PRO23C, PRO23D, PRO243C, PRO243D, PRO268C, PRO268D, PRO271C, PRO271D, PRO62C, PRO62D, PRO65C, PRO65D, PRO6C, PRO6D, SER191C, SER191D, SER196C, SER196D, SER211C, SER211D, SER216C, SER216D, SER217C, SER217D, SER244C, SER244D, SER246C, SER246D, SER293C, SER293D, SER309C, SER309D, SER320C, SER320D, SER63C, SER63D, THR161C, THR161D, THR238C, THR238D, THR313C, THR313D, TRP16C, TRP16D, TYR214C, TYR214D, TYR219C, TYR219D, TYR239C, TYR239D, TYR272C, TYR272D, TYR296C, TYR296D, TYR307C, TYR307D, TYR333C, TYR333D, VAL148C, VAL148D, VAL149D, VAL157C, VAL157D, VAL15C, VAL15D, VAL162C, VAL162D, VAL190C, VAL190D, VAL266C, VAL266D, VAL275C, VAL275D, VAL292C, VAL292D, VAL314C, VAL314D, VAL317C, VAL317D, VAL32C, VAL32D, VAL36C, VAL36D, VAL41C, VAL41D
• C-H: ALA249C, ALA253C, ALA257H, ALA261H, ALA326H, ARG194H, ARG247C, ARG251C, ARG280H, ARG322H, ASN158C, ASN245C, ASP159C, ASP198H, ASP204H, ASP242C, ASP262H, ASP327H, GLN20H, GLU248C, GLU250C, GLU252C, GLU254C, GLU281H, GLY260H, GLY325H, GLY5C, ILE279C, ILE279H, LEU264H, LEU285H, LYS155C, LYS278C, LYS282C, LYS282H, LYS284H, MET263H, MET287H, PRO243C, PRO286H, PRO6C, SER153C, SER244C, SER246C, SER283H, THR203H, TRP16H, TYR356H, VAL157C, VAL288H
• D-G: ALA249G, ALA257D, ALA261D, ALA326D, ARG247G, ARG251G, ARG280D, ARG322D, ASN158G, ASN245G, ASP159G, ASP178D, ASP198D, ASP204D, ASP242G, ASP262D, ASP327D, GLN20D, GLU248G, GLU250G, GLU252G, GLU254G, GLU281D, GLY260D, GLY325D, GLY5G, ILE279D, ILE279G, LEU264D, LEU285D, LYS123D, LYS155G, LYS278G, LYS282D, LYS282G, LYS284D, LYS42D, MET263D, MET287D, PRO243G, PRO286D, PRO6G, SER153G, SER244G, SER246G, SER283D, THR203D, THR205D, TRP16D, TYR356D, VAL157G, VAL288D
• D-H: ALA177D, ALA177H, ALA192D, ALA192H, ALA21D, ALA21H, ALA255D, ALA255H, ALA257D, ALA257H, ALA261D, ALA261H, ALA31D, ALA31H, ALA326D, ALA326H, ALA328D, ALA328H, ALA330D, ALA330H, ALA337D, ALA337H, ALA338D, ALA338H, ALA89D, ALA89H, ARG174D, ARG174H, ARG194D, ARG194H, ARG22D, ARG22H, ARG24D, ARG24H, ARG25D, ARG25H, ARG27D, ARG27H, ARG280D, ARG280H, ARG30D, ARG30H, ARG322D, ARG322H, ARG33D, ARG33H, ASN10D, ASN10H, ASN11D, ASN11H, ASN26D, ASN26H, ASN29D, ASN29H, ASN39D, ASN39H, ASN9D, ASN9H, ASP128D, ASP128H, ASP178D, ASP178H, ASP198D, ASP198H, ASP204D, ASP204H, ASP256D, ASP256H, ASP262D, ASP262H, ASP312D, ASP312H, ASP327D, ASP327H, ASP344D, ASP344H, ASP8D, ASP8H, CYS202D, CYS202H, CYS355D, CYS355H, GLN20D, GLN20H, GLN349D, GLN349H, GLN34D, GLN34H, GLN37D, GLN37H, GLU14D, GLU14H, GLU195D, GLU195H, GLU200D, GLU200H, GLU259D, GLU259H, GLU316D, GLU316H, GLU343D, GLU343H, GLU353D, GLU353H, GLU38D, GLU38H, GLY13D, GLY13H, GLY201D, GLY201H, GLY260D, GLY260H, GLY347H, GLY86D, GLY86H, ILE170D, ILE170H, ILE193H, ILE19D, ILE19H, ILE207D, ILE207H, ILE47D, ILE47H, ILE87D, ILE87H, LEU130D, LEU130H, LEU131D, LEU131H, LEU132D, LEU132H, LEU17D, LEU17H, LEU197D, LEU197H, LEU208D, LEU208H, LEU264D, LEU264H, LEU285D, LEU285H, LEU315D, LEU315H, LEU318D, LEU318H, LEU35D, LEU35H, LEU40D, LEU40H, LEU46D, LEU46H, LYS123D, LYS123H, LYS284D, LYS284H, LYS28D, LYS28H, LYS311D, LYS311H, LYS319D, LYS319H, LYS339H, LYS346D, LYS346H, LYS350D, LYS350H, LYS42D, LYS42H, LYS88D, LYS88H, MET179D, MET179H, MET199D, MET199H, MET263D, MET263H, MET287D, MET287H, MET341D, MET341H, MET345D, MET345H, MET91D, MET91H, PHE321D, PHE351D, PHE351H, PHE90D, PHE90H, PRO127D, PRO127H, PRO18D, PRO18H, PRO23D, PRO23H, PRO286D, PRO286H, PRO354D, PRO354H, PRO43D, PRO43H, SER191D, SER191H, SER196D, SER196H, SER206D, SER206H, SER258D, SER258H, SER320D, SER320H, SER44D, SER44H, SER45D, SER45H, SER84D, SER84H, THR203D, THR203H, THR205D, THR205H, THR313D, THR313H, THR352D, THR352H, TRP16D, TRP16H, TRP340D, TRP340H, TYR12D, TYR12H, TYR356D, TYR356H, TYR48D, TYR48H, TYR85D, TYR85H, VAL129D, VAL129H, VAL15D, VAL15H, VAL180D, VAL180H, VAL190D, VAL190H, VAL288D, VAL288H, VAL314D, VAL314H, VAL317D, VAL317H, VAL329D, VAL329H, VAL32D, VAL32H, VAL342D, VAL342H, VAL36D, VAL36H, VAL41D, VAL41H
• E-F: ALA192E, ALA192F, ALA215E, ALA215F, ALA21E, ALA21F, ALA249E, ALA249F, ALA255E, ALA255F, ALA277E, ALA277F, ALA297E, ALA297F, ALA301E, ALA301F, ALA302E, ALA302F, ALA303E, ALA303F, ALA324E, ALA324F, ARG189E, ARG189F, ARG194E, ARG194F, ARG22E, ARG22F, ARG247E, ARG247F, ARG24E, ARG24F, ARG251E, ARG251F, ARG25E, ARG25F, ARG27E, ARG27F, ARG30E, ARG30F, ARG322E, ARG322F, ARG323E, ARG323F, ARG33E, ARG33F, ASN10E, ASN10F, ASN158E, ASN158F, ASN245E, ASN245F, ASN26E, ASN26F, ASN29E, ASN29F, ASN39E, ASN39F, ASP146F, ASP159E, ASP159F, ASP184E, ASP184F, ASP187E, ASP187F, ASP224E, ASP224F, ASP235E, ASP235F, ASP242E, ASP242F, ASP256F, ASP274E, ASP274F, ASP312E, ASP312F, ASP8E, ASP8F, CYS166E, CYS166F, CYS212E, CYS212F, GLN164E, GLN164F, GLN20E, GLN20F, GLN240E, GLN240F, GLN34E, GLN34F, GLN37E, GLN37F, GLU14E, GLU14F, GLU195E, GLU195F, GLU248E, GLU248F, GLU250E, GLU250F, GLU252E, GLU252F, GLU259E, GLU259F, GLU281E, GLU281F, GLU295E, GLU295F, GLU304E, GLU304F, GLU310E, GLU310F, GLU316E, GLU316F, GLU38E, GLU38F, GLY147E, GLY147F, GLY188E, GLY188F, GLY220E, GLY220F, GLY269E, GLY269F, GLY294E, GLY294F, GLY306E, GLY306F, GLY325E, GLY325F, GLY5E, GLY5F, GLY66F, HIS145F, HIS163E, HIS163F, HIS229E, HIS229F, HIS291E, HIS291F, ILE156E, ILE156F, ILE193E, ILE193F, ILE19E, ILE19F, ILE308E, ILE308F, ILE61E, ILE61F, LEU160E, LEU160F, LEU165E, LEU165F, LEU17E, LEU17F, LEU197E, LEU197F, LEU270E, LEU270F, LEU273E, LEU273F, LEU276E, LEU276F, LEU299E, LEU299F, LEU315E, LEU315F, LEU318E, LEU318F, LEU35E, LEU35F, LEU40E, LEU40F, LEU7E, LEU7F, LYS155E, LYS155F, LYS167E, LYS167F, LYS213E, LYS213F, LYS236E, LYS236F, LYS237E, LYS237F, LYS278E, LYS278F, LYS282E, LYS282F, LYS28E, LYS28F, LYS300E, LYS300F, LYS305E, LYS305F, LYS311E, LYS311F, LYS319E, LYS319F, LYS350E, LYS350F, MET104E, MET104F, MET185E, MET185F, MET186E, MET186F, MET199E, MET199F, MET241E, MET241F, MET298E, MET298F, MET64E, MET64F, PHE218E, PHE218F, PHE222E, PHE222F, PHE321E, PHE321F, PHE351E, PHE351F, PRO18E, PRO18F, PRO221E, PRO221F, PRO23E, PRO23F, PRO243E, PRO243F, PRO268E, PRO268F, PRO271E, PRO271F, PRO62E, PRO62F, PRO65E, PRO65F, PRO6E, PRO6F, SER191E, SER191F, SER196E, SER196F, SER211E, SER211F, SER216E, SER216F, SER217E, SER217F, SER244E, SER244F, SER246E, SER246F, SER258F, SER293E, SER293F, SER309E, SER309F, SER320E, SER320F, SER63E, SER63F, THR161E, THR161F, THR238E, THR238F, THR313E, THR313F, TRP16E, TRP16F, TYR214E, TYR214F, TYR219E, TYR219F, TYR239E, TYR239F, TYR272E, TYR272F, TYR296E, TYR296F, TYR307E, TYR307F, TYR333E, TYR333F, VAL148E, VAL148F, VAL149E, VAL157E, VAL157F, VAL15E, VAL15F, VAL162E, VAL162F, VAL190E, VAL190F, VAL266E, VAL266F, VAL275E, VAL275F, VAL292E, VAL292F, VAL314E, VAL314F, VAL317E, VAL317F, VAL32E, VAL32F, VAL36E, VAL36F, VAL41E, VAL41F
• E-G: ALA249E, ALA257G, ALA261G, ALA326G, ARG247E, ARG251E, ARG280G, ARG322G, ASN158E, ASN245E, ASP159E, ASP178G, ASP198G, ASP204G, ASP242E, ASP262G, ASP327G, CYS202G, GLN20G, GLU248E, GLU250E, GLU252E, GLU254E, GLU281G, GLY260G, GLY325G, GLY5E, ILE279G, LEU264G, LEU285G, LYS155E, LYS278E, LYS282E, LYS282G, LYS284G, MET263G, MET287G, PRO243E, PRO286G, PRO6E, SER153E, SER244E, SER246E, SER283G, THR203G, THR205G, THR238E, TRP16G, TYR356G, VAL157E, VAL288G
• F-G: ALA177F, ALA177G, ALA192F, ALA192G, ALA21F, ALA21G, ALA255F, ALA255G, ALA257F, ALA257G, ALA261F, ALA261G, ALA31F, ALA31G, ALA326F, ALA326G, ALA328F, ALA328G, ALA330F, ALA330G, ALA337F, ALA337G, ALA338F, ALA338G, ALA89F, ALA89G, ARG174F, ARG174G, ARG194F, ARG194G, ARG22F, ARG22G, ARG24F, ARG24G, ARG25F, ARG25G, ARG27F, ARG27G, ARG280F, ARG280G, ARG30F, ARG30G, ARG322F, ARG322G, ARG33F, ARG33G, ARG83F, ARG83G, ASN10F, ASN10G, ASN11F, ASN11G, ASN26F, ASN26G, ASN29F, ASN29G, ASN39F, ASN39G, ASN9F, ASN9G, ASP128F, ASP128G, ASP178F, ASP178G, ASP198F, ASP198G, ASP204F, ASP204G, ASP256F, ASP256G, ASP262F, ASP262G, ASP312F, ASP312G, ASP327F, ASP327G, ASP344F, ASP344G, ASP8F, ASP8G, CYS202F, CYS202G, CYS355F, CYS355G, GLN20F, GLN20G, GLN349F, GLN349G, GLN34F, GLN34G, GLN37F, GLN37G, GLU14F, GLU14G, GLU195F, GLU195G, GLU200F, GLU200G, GLU259F, GLU259G, GLU316F, GLU316G, GLU343F, GLU343G, GLU353F, GLU353G, GLU38F, GLU38G, GLY13F, GLY13G, GLY201F, GLY201G, GLY260F, GLY260G, GLY347G, GLY86F, GLY86G, ILE170F, ILE170G, ILE19F, ILE19G, ILE207F, ILE207G, ILE47F, ILE47G, ILE87F, ILE87G, LEU130F, LEU130G, LEU131F, LEU131G, LEU132F, LEU132G, LEU17F, LEU17G, LEU197F, LEU197G, LEU208F, LEU208G, LEU264F, LEU264G, LEU285F, LEU285G, LEU315F, LEU315G, LEU318F, LEU318G, LEU35F, LEU35G, LEU40F, LEU40G, LEU46F, LEU46G, LYS123F, LYS123G, LYS284F, LYS284G, LYS28F, LYS28G, LYS311F, LYS311G, LYS319F, LYS319G, LYS346F, LYS346G, LYS350F, LYS350G, LYS42F, LYS42G, LYS88F, LYS88G, MET179F, MET179G, MET199F, MET199G, MET263F, MET263G, MET287F, MET287G, MET341F, MET341G, MET345F, MET345G, MET91F, MET91G, PHE321F, PHE351F, PHE351G, PHE90F, PHE90G, PRO127F, PRO127G, PRO18F, PRO18G, PRO23F, PRO23G, PRO286F, PRO286G, PRO354F, PRO354G, PRO43F, PRO43G, SER191F, SER191G, SER196F, SER196G, SER206F, SER206G, SER258F, SER258G, SER320F, SER320G, SER44F, SER44G, SER45F, SER45G, SER84F, SER84G, THR203F, THR203G, THR205F, THR205G, THR313F, THR313G, THR352F, THR352G, TRP16F, TRP16G, TRP340F, TRP340G, TYR12F, TYR12G, TYR356F, TYR356G, TYR48F, TYR48G, TYR85F, TYR85G, VAL129F, VAL129G, VAL15F, VAL15G, VAL180F, VAL180G, VAL190F, VAL190G, VAL288F, VAL288G, VAL314F, VAL314G, VAL317F, VAL317G, VAL329F, VAL329G, VAL32F, VAL32G, VAL342F, VAL342G, VAL36F, VAL36G, VAL41F, VAL41G
• F-H: ALA249H, ALA257F, ALA261F, ALA326F, ARG247H, ARG251H, ARG280F, ARG322F, ASN11F, ASN158H, ASN245H, ASP159H, ASP198F, ASP204F, ASP242H, ASP262F, ASP327F, GLN20F, GLU248H, GLU250H, GLU252H, GLU254H, GLU281F, GLY260F, GLY325F, GLY5H, ILE279F, LEU264F, LEU285F, LYS155H, LYS282F, LYS282H, LYS284F, MET263F, MET287F, PRO243H, PRO286F, PRO6H, SER244H, SER246H, SER283F, THR203F, TRP16F, TYR356F, VAL157H, VAL288F
• G-H: ALA192G, ALA192H, ALA215G, ALA215H, ALA21G, ALA21H, ALA249G, ALA249H, ALA255G, ALA255H, ALA277G, ALA277H, ALA297G, ALA297H, ALA301G, ALA301H, ALA302G, ALA302H, ALA303G, ALA303H, ALA324G, ALA324H, ARG189G, ARG189H, ARG194G, ARG194H, ARG22G, ARG22H, ARG247G, ARG247H, ARG24G, ARG24H, ARG251G, ARG251H, ARG25G, ARG25H, ARG27G, ARG27H, ARG30G, ARG30H, ARG322G, ARG322H, ARG323G, ARG323H, ARG33G, ARG33H, ASN10G, ASN10H, ASN158G, ASN158H, ASN245G, ASN245H, ASN26G, ASN26H, ASN29G, ASN29H, ASN39G, ASN39H, ASN9H, ASP150G, ASP159G, ASP159H, ASP184G, ASP184H, ASP187G, ASP187H, ASP224G, ASP224H, ASP235G, ASP235H, ASP242G, ASP242H, ASP256G, ASP256H, ASP274G, ASP274H, ASP312G, ASP312H, ASP8G, ASP8H, CYS166G, CYS166H, CYS212G, CYS212H, GLN164G, GLN164H, GLN20G, GLN20H, GLN240G, GLN240H, GLN34G, GLN34H, GLN37G, GLN37H, GLU14G, GLU14H, GLU195G, GLU195H, GLU248G, GLU248H, GLU250G, GLU250H, GLU252G, GLU252H, GLU259G, GLU259H, GLU281G, GLU281H, GLU295G, GLU295H, GLU304G, GLU304H, GLU310G, GLU310H, GLU316G, GLU316H, GLU38G, GLU38H, GLY147G, GLY147H, GLY154G, GLY154H, GLY188G, GLY188H, GLY220G, GLY220H, GLY269G, GLY269H, GLY294G, GLY294H, GLY306G, GLY306H, GLY325G, GLY325H, GLY5G, GLY5H, HIS145G, HIS145H, HIS163G, HIS163H, HIS229G, HIS229H, HIS291G, HIS291H, ILE156G, ILE156H, ILE193G, ILE193H, ILE19G, ILE19H, ILE308G, ILE308H, ILE61G, ILE61H, LEU160G, LEU160H, LEU165G, LEU165H, LEU17G, LEU17H, LEU197G, LEU197H, LEU270G, LEU270H, LEU273G, LEU273H, LEU276G, LEU276H, LEU299G, LEU299H, LEU315G, LEU315H, LEU318G, LEU318H, LEU35G, LEU35H, LEU40G, LEU40H, LEU7G, LEU7H, LYS155G, LYS155H, LYS167G, LYS167H, LYS213G, LYS213H, LYS236G, LYS236H, LYS237G, LYS237H, LYS278G, LYS278H, LYS282G, LYS282H, LYS28G, LYS28H, LYS300G, LYS300H, LYS305G, LYS305H, LYS311G, LYS311H, LYS319G, LYS319H, LYS350G, LYS350H, MET104G, MET104H, MET185G, MET185H, MET186G, MET186H, MET199G, MET199H, MET241G, MET241H, MET298G, MET298H, MET64G, MET64H, PHE218G, PHE218H, PHE222H, PHE321G, PHE321H, PHE351G, PHE351H, PRO18G, PRO18H, PRO221G, PRO221H, PRO23G, PRO23H, PRO243G, PRO243H, PRO268G, PRO268H, PRO271G, PRO271H, PRO62G, PRO62H, PRO65G, PRO65H, PRO6G, PRO6H, SER191G, SER191H, SER196G, SER196H, SER211G, SER211H, SER216G, SER216H, SER217G, SER217H, SER244G, SER244H, SER246G, SER246H, SER258H, SER293G, SER293H, SER309G, SER309H, SER320G, SER320H, SER63G, SER63H, THR161G, THR161H, THR238G, THR238H, THR313G, THR313H, TRP16G, TRP16H, TYR214G, TYR214H, TYR219G, TYR219H, TYR239G, TYR239H, TYR272G, TYR272H, TYR296G, TYR296H, TYR307G, TYR307H, TYR333G, TYR333H, VAL148G, VAL148H, VAL149G, VAL149H, VAL157G, VAL157H, VAL15G, VAL15H, VAL162G, VAL162H, VAL190G, VAL190H, VAL266G, VAL266H, VAL275G, VAL275H, VAL292G, VAL292H, VAL314G, VAL314H, VAL317G, VAL317H, VAL32G, VAL32H, VAL36G, VAL36H, VAL41G, VAL41H