3O8O

structure of phosphofructokinase from saccharomyces cerevisiae

• Total interactions analyzed: 28
• Total true interactions: 10
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 273
  • Norm. En. per Res.: -3.1657
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-129.9919	-79.6152	-654.628	-864.235	273	65	11	27642	12	96	94
A-D	-26.6812	-8.4622	-120.982	-156.1254	59	15	8	6163	0	17	14
A-E	-4.7103	6.605	-83.9757	-82.081	44	4	0	3442	0	4	9
B-C	0.0	-11.667	-97.2214	-108.8884	56	9	8	5326	0	16	15
C-D	-133.7355	-81.3562	-625.091	-840.1827	271	63	11	26694	13	95	93
C-G	-11.8604	8.9852	-100.471	-103.3462	46	15	2	4031	0	6	9
E-F	-120.3456	-86.2198	-587.523	-794.0884	258	47	11	25186	13	93	95
E-H	-43.7059	-4.2914	-118.849	-166.8462	65	36	8	6999	1	18	15
F-G	-49.3777	-5.4543	-118.386	-173.218	66	27	9	6627	0	18	15
G-H	-101.8246	-70.237	-575.986	-748.0476	257	38	10	24927	14	93	92

Interface residues

• A-B: ALA208B, ALA269B, ALA277A, ALA370B, ALA376B, ALA378B, ALA384A, ALA386A, ALA596B, ALA598B, ALA603A, ALA606A, ALA736B, ALA742A, ALA748B, ALA754A, ALA756A, ALA849B, ALA855A, ARG270B, ARG278A, ARG366B, ARG374A, ARG383B, ARG391A, ARG439B, ARG447A, ARG475B, ARG484B, ARG491A, ARG631B, ARG636B, ARG649B, ARG658B, ARG665A, ARG752B, ARG754B, ARG758A, ARG759A, ARG760A, ARG810B, ARG812B, ARG818A, ARG853A, ASN212B, ASN221A, ASN265B, ASN379B, ASN593B, ASN602B, ASN609A, ASN624B, ASN631A, ASN652A, ASN655A, ASN657B, ASN664A, ASN745A, ASN817A, ASP207B, ASP216A, ASP365B, ASP372B, ASP380A, ASP383A, ASP473B, ASP480A, ASP742B, ASP748A, ASP749A, ASP813A, CYS741B, CYS764A, GLN483B, GLN490A, GLN746B, GLN752A, GLN761B, GLN767A, GLN855B, GLN856B, GLN861A, GLN862A, GLU234B, GLU243A, GLU261B, GLU269A, GLU373A, GLU375B, GLU377A, GLU641A, GLU653B, GLU660A, GLU739B, GLU808B, GLU816A, GLY205B, GLY206B, GLY210B, GLY214A, GLY215A, GLY244A, GLY262B, GLY263B, GLY267B, GLY270A, GLY271A, GLY275A, GLY308A, GLY478A, GLY480B, GLY485B, GLY486B, GLY487A, GLY492A, GLY493A, GLY595B, GLY599B, GLY600B, GLY602A, GLY625B, GLY628B, GLY632A, GLY635A, GLY650B, GLY651B, GLY655B, GLY657A, GLY658A, GLY662A, GLY809B, GLY811B, GLY815A, GLY848A, GLY852B, GLY857B, GLY858A, GLY858B, GLY863A, GLY864A, HIS381B, HIS389A, HIS481B, HIS488A, HIS600A, HIS632B, HIS853B, HIS859A, ILE266B, ILE274A, ILE347B, ILE355A, ILE367B, ILE371B, ILE375A, ILE382A, ILE476B, ILE485A, ILE601B, ILE654B, ILE661A, ILE750A, ILE856A, LEU273A, LEU479A, LEU479B, LEU486A, LEU608A, LEU656A, LEU717B, LEU743A, LEU859B, LYS369B, LYS387A, LYS482A, LYS643A, LYS745B, LYS751A, LYS814A, LYS847B, LYS849A, MET211B, MET220A, MET233B, MET378A, MET390B, MET398A, MET630A, PHE385B, PHE393A, PHE756B, PHE762A, PRO209B, PRO218A, PRO597B, PRO604A, PRO848B, PRO851B, PRO857A, PRO860B, PRO866A, SER204B, SER213A, SER217A, SER370A, SER380B, SER382B, SER388A, SER390A, SER605A, SER627B, SER634A, SER634B, SER652B, SER659A, SER666A, SER747B, SER749B, SER750B, SER753A, SER755A, THR203B, THR212A, THR264B, THR268B, THR272A, THR276A, THR377B, THR385A, THR474B, THR477B, THR478B, THR481A, THR484A, THR487B, THR494A, THR639A, THR656B, THR663A, THR732B, THR738A, THR747A, THR751B, THR757A, THR830B, THR854A, TRP646B, TRP653A, TYR242A, TYR246B, TYR254A, TYR373B, TYR381A, TYR623B, TYR740B, TYR746A, TYR850B, VAL374B, VAL379A, VAL387B, VAL395A, VAL482B, VAL483A, VAL489A, VAL489B, VAL659B, VAL743B, VAL744B, VAL758B, VAL852A, VAL854B, VAL860A, VAL865A
• A-D: ALA797A, ALA823D, ALA826D, ALA833D, ALA838D, ALA839A, ALA840D, ALA845A, ARG800A, ARG825A, ASP795A, ASP796D, ASP802A, ASP840A, ASP841D, GLN792D, GLN836A, GLU786D, GLU791D, GLU795D, GLU798D, GLU801A, GLU834D, GLU839D, GLU844A, GLY787D, ILE788D, ILE794A, ILE797D, ILE799A, ILE803A, ILE836D, ILE841A, ILE842A, LEU790D, LEU793D, LEU796A, LEU827D, LEU832D, LEU837A, LEU838A, LYS793A, LYS807A, LYS825D, LYS831D, LYS847A, SER789D, SER794D, SER798A, SER824D, SER828D, SER830A, SER831A, SER834A, SER843A, THR837D, TYR833A, VAL832A, VAL835D
• A-E: ALA676A, ALA676E, ARG706A, ARG706E, ASN682A, ASN682E, ASN713A, ASN713E, ASP671A, ASP671E, GLN680A, GLN680E, GLN708A, GLN708E, GLY673A, GLY673E, GLY705A, GLY705E, HIS709A, HIS709E, ILE637A, ILE637E, ILE675A, ILE675E, ILE711A, ILE711E, LEU672A, LEU672E, LYS681A, LYS681E, LYS683A, LYS683E, PHE679A, PHE679E, PRO710A, PRO710E, THR674A, THR674E, THR707A, THR707E, TYR677A, TYR677E, TYR678A, TYR678E
• B-C: ALA797C, ALA823B, ALA826B, ALA833B, ALA838B, ALA839C, ALA840B, ALA845C, ARG800C, ARG957B, ASP795C, ASP796B, ASP840C, ASP841B, GLN792B, GLN836C, GLU791B, GLU795B, GLU798B, GLU834B, GLU839B, GLU844C, GLY787B, ILE788B, ILE794C, ILE797B, ILE799C, ILE803C, ILE836B, ILE841C, ILE842C, LEU790B, LEU793B, LEU796C, LEU827B, LEU832B, LEU837C, LEU838C, LYS793C, LYS807C, LYS825B, LYS831B, LYS847C, SER789B, SER794B, SER798C, SER824B, SER828B, SER830C, SER831C, SER834C, SER843C, THR837B, TYR833C, VAL832C, VAL835B
• C-D: ALA208D, ALA269D, ALA277C, ALA370D, ALA376D, ALA378D, ALA384C, ALA386C, ALA596D, ALA598D, ALA603C, ALA606C, ALA736D, ALA742C, ALA748D, ALA754C, ALA756C, ALA849D, ALA855C, ARG270D, ARG278C, ARG366D, ARG374C, ARG383D, ARG391C, ARG439D, ARG447C, ARG475D, ARG484D, ARG491C, ARG631D, ARG636D, ARG649D, ARG658D, ARG665C, ARG752D, ARG754D, ARG758C, ARG759C, ARG760C, ARG810D, ARG812D, ARG818C, ARG853C, ASN212D, ASN221C, ASN265D, ASN379D, ASN593D, ASN602D, ASN609C, ASN624D, ASN631C, ASN652C, ASN655C, ASN657D, ASN664C, ASN745C, ASN817C, ASP207D, ASP216C, ASP365D, ASP372D, ASP380C, ASP383C, ASP473D, ASP480C, ASP649C, ASP742D, ASP748C, ASP749C, ASP813C, CYS741D, GLN483D, GLN490C, GLN746D, GLN752C, GLN761D, GLN855D, GLN856D, GLN861C, GLN862C, GLU234D, GLU243C, GLU261D, GLU269C, GLU373C, GLU375D, GLU377C, GLU641C, GLU651C, GLU653D, GLU660C, GLU739D, GLU808D, GLU816C, GLY205D, GLY206D, GLY210D, GLY214C, GLY215C, GLY235D, GLY262D, GLY263D, GLY267D, GLY270C, GLY271C, GLY275C, GLY478C, GLY480D, GLY485D, GLY486D, GLY487C, GLY492C, GLY493C, GLY595D, GLY599D, GLY600D, GLY602C, GLY625D, GLY628D, GLY632C, GLY635C, GLY650D, GLY651D, GLY655D, GLY657C, GLY658C, GLY662C, GLY809D, GLY811D, GLY815C, GLY848C, GLY852D, GLY857D, GLY858C, GLY858D, GLY863C, GLY864C, HIS381D, HIS389C, HIS481D, HIS488C, HIS600C, HIS632D, HIS853D, HIS859C, ILE266D, ILE274C, ILE347D, ILE355C, ILE367D, ILE371D, ILE375C, ILE382C, ILE475C, ILE476D, ILE485C, ILE601D, ILE654D, ILE661C, ILE750C, ILE856C, LEU273C, LEU479C, LEU479D, LEU486C, LEU608C, LEU656C, LEU717D, LEU743C, LEU859D, LYS369D, LYS387C, LYS482C, LYS643C, LYS745D, LYS751C, LYS814C, LYS847D, LYS849C, MET211D, MET220C, MET233D, MET378C, MET390D, MET398C, MET630C, PHE385D, PHE393C, PHE756D, PHE762C, PRO209D, PRO218C, PRO597D, PRO604C, PRO848D, PRO851D, PRO857C, PRO860D, PRO866C, SER204D, SER213C, SER217C, SER380D, SER382D, SER388C, SER390C, SER605C, SER627D, SER634D, SER648D, SER652D, SER659C, SER666C, SER747D, SER749D, SER750D, SER753C, SER755C, THR203D, THR212C, THR264D, THR268D, THR272C, THR276C, THR377D, THR385C, THR474D, THR477D, THR478D, THR481C, THR484C, THR487D, THR494C, THR639C, THR656D, THR663C, THR732D, THR738C, THR747C, THR751D, THR757C, THR830D, THR854C, TRP646D, TRP653C, TYR242C, TYR246D, TYR254C, TYR373D, TYR381C, TYR623D, TYR740D, TYR746C, TYR850D, VAL374D, VAL379C, VAL387D, VAL395C, VAL482D, VAL483C, VAL489C, VAL496C, VAL743D, VAL744D, VAL758D, VAL852C, VAL854D, VAL860C, VAL865C
• C-G: ALA676C, ALA676G, ARG706C, ARG706G, ASN682C, ASN682G, ASN713C, ASN713G, ASP671C, ASP671G, GLN680C, GLN680G, GLN708C, GLN708G, GLY673C, GLY673G, GLY705C, GLY705G, HIS709C, HIS709G, ILE637C, ILE637G, ILE675C, ILE675G, ILE711C, ILE711G, ILE714C, LEU672C, LEU672G, LYS681C, LYS681G, LYS683C, LYS683G, PHE679C, PHE679G, PHE712C, PRO710C, PRO710G, THR674C, THR674G, THR707C, THR707G, TYR677C, TYR677G, TYR678C, TYR678G
• E-F: ALA208F, ALA269F, ALA277E, ALA370F, ALA376F, ALA378F, ALA384E, ALA386E, ALA596F, ALA598F, ALA603E, ALA606E, ALA736F, ALA742E, ALA748F, ALA754E, ALA756E, ALA849F, ALA855E, ARG270F, ARG278E, ARG366F, ARG374E, ARG383F, ARG391E, ARG439F, ARG447E, ARG475F, ARG484F, ARG491E, ARG631F, ARG636F, ARG649F, ARG658F, ARG665E, ARG752F, ARG754F, ARG758E, ARG759E, ARG760E, ARG810F, ARG812F, ARG818E, ARG853E, ASN212F, ASN221E, ASN265F, ASN379F, ASN593F, ASN602F, ASN609E, ASN624F, ASN631E, ASN652E, ASN655E, ASN657F, ASN664E, ASN745E, ASN817E, ASP207F, ASP216E, ASP365F, ASP372F, ASP380E, ASP383E, ASP473F, ASP480E, ASP649E, ASP742F, ASP748E, ASP749E, CYS741F, GLN483F, GLN490E, GLN746F, GLN752E, GLN855F, GLN856F, GLN861E, GLN862E, GLU234F, GLU243E, GLU261F, GLU269E, GLU373E, GLU375F, GLU377E, GLU641E, GLU651E, GLU653F, GLU660E, GLU739F, GLU808F, GLU816E, GLY205F, GLY206F, GLY210F, GLY214E, GLY215E, GLY235F, GLY262F, GLY263F, GLY267F, GLY270E, GLY271E, GLY275E, GLY478E, GLY480F, GLY485F, GLY486F, GLY487E, GLY492E, GLY493E, GLY595F, GLY599F, GLY600F, GLY602E, GLY632E, GLY635E, GLY650F, GLY651F, GLY655F, GLY657E, GLY658E, GLY662E, GLY809F, GLY811F, GLY852F, GLY857F, GLY858E, GLY858F, GLY863E, GLY864E, HIS381F, HIS389E, HIS481F, HIS488E, HIS600E, HIS632F, HIS853F, HIS859E, ILE266F, ILE274E, ILE347F, ILE355E, ILE367F, ILE371F, ILE375E, ILE382E, ILE475E, ILE476F, ILE485E, ILE601F, ILE654F, ILE661E, ILE750E, ILE856E, LEU273E, LEU479E, LEU479F, LEU486E, LEU608E, LEU656E, LEU859F, LYS369F, LYS387E, LYS482E, LYS643E, LYS745F, LYS751E, LYS814E, LYS847F, MET211F, MET220E, MET233F, MET378E, MET390F, MET398E, MET630E, PHE385F, PHE393E, PHE756F, PHE762E, PRO209F, PRO218E, PRO597F, PRO604E, PRO848F, PRO851F, PRO857E, PRO860F, PRO866E, SER204F, SER213E, SER217E, SER380F, SER382F, SER388E, SER390E, SER605E, SER627F, SER652F, SER659E, SER666E, SER747F, SER749F, SER750F, SER753E, SER755E, THR203F, THR212E, THR264F, THR268F, THR272E, THR276E, THR377F, THR385E, THR474F, THR477F, THR478F, THR481E, THR484E, THR487F, THR494E, THR639E, THR656F, THR663E, THR732F, THR738E, THR747E, THR751F, THR757E, THR830F, THR854E, TRP646F, TRP653E, TYR242E, TYR246F, TYR373F, TYR381E, TYR623F, TYR740F, TYR746E, TYR850F, VAL374F, VAL379E, VAL387F, VAL395E, VAL482F, VAL483E, VAL489E, VAL743F, VAL744F, VAL758F, VAL852E, VAL854F, VAL860E, VAL865E
• E-H: ALA797E, ALA823H, ALA826H, ALA833H, ALA838H, ALA839E, ALA840H, ALA845E, ARG800E, ARG825E, ASN822H, ASP795E, ASP796H, ASP802E, ASP840E, ASP841H, GLN792H, GLN836E, GLU786H, GLU791H, GLU795H, GLU798H, GLU801E, GLU834H, GLU839H, GLU844E, GLY787H, GLY848E, ILE788H, ILE794E, ILE797H, ILE799E, ILE803E, ILE836H, ILE841E, ILE842E, LEU790H, LEU793H, LEU796E, LEU827H, LEU832H, LEU837E, LEU838E, LYS793E, LYS807E, LYS819H, LYS825H, LYS831H, LYS847E, SER789H, SER794H, SER798E, SER824H, SER828H, SER830E, SER831E, SER834E, SER843E, THR804E, THR821H, THR830H, THR837H, TYR833E, VAL832E, VAL835H
• F-G: ALA797G, ALA823F, ALA826F, ALA833F, ALA838F, ALA839G, ALA840F, ALA845G, ARG800G, ARG825G, ASN822F, ASP795G, ASP802G, ASP840G, ASP841F, GLN792F, GLN836G, GLU786F, GLU791F, GLU795F, GLU798F, GLU801G, GLU834F, GLU839F, GLU844G, GLY787F, GLY848G, ILE788F, ILE794G, ILE797F, ILE799G, ILE803G, ILE836F, ILE841G, ILE842G, LEU790F, LEU793F, LEU796G, LEU827F, LEU832F, LEU837G, LEU838G, LYS793G, LYS807G, LYS819F, LYS825F, LYS831F, LYS847G, SER789F, SER794F, SER798G, SER824F, SER828F, SER830G, SER831G, SER834G, SER843G, SER846G, THR804G, THR821F, THR830F, THR835G, THR837F, TYR833G, VAL832G, VAL835F
• G-H: ALA208H, ALA269H, ALA277G, ALA370H, ALA376H, ALA378H, ALA384G, ALA386G, ALA596H, ALA598H, ALA603G, ALA606G, ALA736H, ALA742G, ALA748H, ALA754G, ALA756G, ALA849H, ALA855G, ARG270H, ARG278G, ARG366H, ARG374G, ARG383H, ARG391G, ARG439H, ARG447G, ARG475H, ARG484H, ARG491G, ARG631H, ARG636H, ARG649H, ARG658H, ARG665G, ARG752H, ARG754H, ARG758G, ARG759G, ARG760G, ARG810H, ARG812H, ARG818G, ARG853G, ASN212H, ASN221G, ASN265H, ASN379H, ASN593H, ASN602H, ASN609G, ASN624H, ASN631G, ASN652G, ASN655G, ASN657H, ASN664G, ASN745G, ASN817G, ASP207H, ASP216G, ASP365H, ASP372H, ASP380G, ASP383G, ASP473H, ASP480G, ASP742H, ASP748G, ASP749G, CYS741H, GLN483H, GLN490G, GLN746H, GLN752G, GLN855H, GLN856H, GLN861G, GLN862G, GLU234H, GLU243G, GLU261H, GLU269G, GLU373G, GLU375H, GLU377G, GLU641G, GLU653H, GLU660G, GLU739H, GLU808H, GLU816G, GLY205H, GLY206H, GLY210H, GLY214G, GLY215G, GLY235H, GLY262H, GLY263H, GLY267H, GLY270G, GLY271G, GLY275G, GLY478G, GLY480H, GLY485H, GLY486H, GLY487G, GLY492G, GLY493G, GLY595H, GLY599H, GLY600H, GLY602G, GLY628H, GLY632G, GLY635G, GLY650H, GLY651H, GLY655H, GLY657G, GLY658G, GLY662G, GLY809H, GLY811H, GLY848G, GLY852H, GLY857H, GLY858G, GLY858H, GLY863G, GLY864G, HIS381H, HIS389G, HIS481H, HIS488G, HIS600G, HIS632H, HIS853H, HIS859G, ILE266H, ILE274G, ILE347H, ILE355G, ILE367H, ILE371H, ILE382G, ILE475G, ILE476H, ILE485G, ILE601H, ILE654H, ILE661G, ILE750G, ILE856G, LEU273G, LEU479G, LEU479H, LEU486G, LEU608G, LEU656G, LEU859H, LYS369H, LYS387G, LYS482G, LYS643G, LYS751G, LYS814G, LYS847H, LYS849G, MET211H, MET220G, MET233H, MET378G, MET390H, MET398G, MET630G, PHE385H, PHE393G, PHE756H, PHE762G, PRO209H, PRO218G, PRO597H, PRO604G, PRO848H, PRO851H, PRO857G, PRO860H, PRO866G, SER204H, SER213G, SER217G, SER380H, SER382H, SER388G, SER390G, SER605G, SER627H, SER634G, SER648H, SER652H, SER659G, SER666G, SER747H, SER749H, SER750H, SER753G, SER755G, THR203H, THR212G, THR264H, THR268H, THR272G, THR276G, THR377H, THR385G, THR474H, THR477H, THR478H, THR481G, THR484G, THR487H, THR494G, THR639G, THR656H, THR663G, THR732H, THR738G, THR747G, THR751H, THR757G, THR854G, TRP646H, TRP653G, TYR242G, TYR246H, TYR373H, TYR381G, TYR623H, TYR740H, TYR746G, TYR850H, VAL374H, VAL379G, VAL387H, VAL395G, VAL482H, VAL483G, VAL489G, VAL743H, VAL744H, VAL758H, VAL854H, VAL860G, VAL865G