3O8J

crystal structure of 2-methylcitrate synthase (prpc) from salmonella typhimurium

• Total interactions analyzed: 45
• Total true interactions: 25
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 296
  • Norm. En. per Res.: -4.5918
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-226.816	-115.781	-1016.58	-1359.177	296	40	27	39366	20	75	100
A-C	0.0	13.0784	-91.8836	-78.8052	73	0	3	3670	0	32	33
A-D	0.0	0.0	-2.6424	-2.6424	19	0	1	299	0	2	3
A-I	0.0	5.5498	-97.5016	-91.9518	81	1	3	4072	0	37	35
A-J	0.0	-8.0842	-6.3404	-14.4246	12	0	0	429	1	8	8
B-C	0.0	4.3839	-4.2175	0.1664	8	0	0	292	0	8	8
B-D	0.0	18.9544	-101.168	-82.2137	75	1	3	3869	1	28	31
B-I	0.0	0.0	-2.4641	-2.4641	15	0	1	297	0	2	3
B-J	0.0	0.1411	-90.701	-90.5599	74	1	3	3901	1	31	34
C-D	-203.0103	-78.2625	-941.585	-1222.8578	285	46	25	36122	15	72	95
C-E	0.0	12.9311	-102.423	-89.4919	74	0	3	3921	0	30	32
C-F	0.0	0.0	-3.0488	-3.0488	15	0	1	320	0	2	3
D-E	0.0	-0.8857	-2.1266	-3.0123	8	0	0	254	0	8	8
D-F	0.0	3.3211	-91.7147	-88.3936	80	1	3	3684	0	32	32
E-F	-198.9521	-78.2286	-1021.77	-1298.9507	296	32	26	38478	12	76	103
E-G	0.0	31.8531	-109.324	-77.4709	82	1	3	4524	0	38	36
E-H	0.0	0.0	-3.0539	-3.0539	17	0	1	328	0	2	3
F-G	0.0	-1.6053	-5.8893	-7.4946	11	0	0	419	0	8	8
F-H	0.0	5.0088	-97.0962	-92.0874	83	0	3	4047	0	36	35
G-H	-187.0821	-62.4575	-1010.47	-1260.0096	292	44	24	38109	16	74	105
G-I	0.0	4.9421	-92.3436	-87.4015	76	1	3	3885	1	29	34
G-J	0.0	0.0	-2.4293	-2.4293	20	0	1	288	0	2	3
H-I	0.0	0.0	-2.3831	-2.3831	9	0	0	249	0	8	8
H-J	0.0	-6.438	-87.9051	-94.3431	69	0	3	3665	0	29	31
I-J	-227.7565	-76.5611	-1008.38	-1312.6977	293	52	24	38083	19	74	100

Interface residues

• A-B: ALA102A, ALA102B, ALA103A, ALA103B, ALA116A, ALA116B, ALA204A, ALA204B, ALA213A, ALA213B, ALA222A, ALA222B, ALA226A, ALA226B, ALA229A, ALA229B, ALA27A, ALA27B, ALA31A, ALA31B, ALA372A, ALA372B, ALA53A, ALA53B, ALA91A, ALA91B, ALA99A, ALA99B, ARG111A, ARG111B, ARG210A, ARG210B, ARG231A, ARG231B, ARG362A, ARG362B, ARG369A, ARG369B, ARG380A, ARG380B, ARG388A, ARG388B, ARG45A, ARG45B, ARG73A, ARG73B, ARG94A, ARG94B, ASN203A, ASN203B, ASN29A, ASN29B, ASN365A, ASN365B, ASN373A, ASN373B, ASN77A, ASN77B, ASN92A, ASN92B, ASP108A, ASP108B, ASP218A, ASP218B, ASP364A, ASP364B, ASP379A, ASP379B, ASP386A, ASP386B, ASP387A, ASP387B, ASP41A, ASP41B, ASP48A, ASP48B, ASP51A, ASP51B, ASP74A, ASP74B, CYS119A, CYS119B, CYS33A, CYS33B, CYS389A, CYS389B, CYS56A, CYS56B, GLN361A, GLN361B, GLU123A, GLU123B, GLU125A, GLU125B, GLU201A, GLU201B, GLU360A, GLU360B, GLU378A, GLU378B, GLU54A, GLU54B, GLU57A, GLU57B, GLU59B, GLU60A, GLU60B, GLU75A, GLU75B, GLU98A, GLU98B, GLY113A, GLY113B, GLY118A, GLY118B, GLY214A, GLY214B, GLY216A, GLY216B, GLY225A, GLY225B, GLY228A, GLY228B, GLY232A, GLY232B, GLY236A, GLY236B, GLY237A, GLY237B, GLY28A, GLY28B, GLY376A, GLY376B, GLY46A, GLY46B, GLY68A, GLY68B, HIS105A, HIS105B, HIS127A, HIS127B, HIS235A, HIS235B, HIS357A, HIS357B, HIS43A, HIS43B, HIS55A, HIS55B, HIS63A, HIS63B, ILE212A, ILE212B, ILE223A, ILE223B, ILE224A, ILE224B, ILE227A, ILE227B, ILE367A, ILE367B, ILE368A, ILE368B, ILE385A, ILE385B, LEU100A, LEU100B, LEU117A, LEU117B, LEU121A, LEU121B, LEU230A, LEU230B, LEU32A, LEU32B, LEU42A, LEU42B, LEU50A, LEU50B, LEU52A, LEU52B, LEU64A, LEU64B, LEU70A, LEU70B, LEU76A, LEU76B, LEU97A, LEU97B, LYS234A, LYS234B, LYS366A, LYS37A, LYS37B, LYS69A, LYS69B, LYS80A, LYS80B, MET107A, MET107B, MET110A, MET110B, PHE202A, PHE202B, PHE207A, PHE207B, PHE382A, PHE382B, PRO101A, PRO101B, PRO106A, PRO106B, PRO122A, PRO122B, PRO233A, PRO233B, PRO26A, PRO26B, PRO275A, PRO275B, PRO370A, PRO370B, PRO377A, PRO377B, PRO381A, PRO381B, PRO71A, PRO71B, SER104A, SER104B, SER115A, SER115B, SER205A, SER205B, SER209A, SER209B, SER217A, SER217B, SER221A, SER221B, SER371A, SER371B, SER384A, SER384B, SER38A, SER38B, THR112A, THR112B, THR120A, THR120B, THR206A, THR206B, THR208A, THR208B, THR215A, THR215B, THR30A, THR30B, THR34A, THR34B, THR375A, THR375B, THR72A, THR72B, THR95A, THR95B, TRP150A, TRP150B, TYR220A, TYR220B, TYR374A, TYR374B, TYR44A, TYR44B, TYR47A, TYR47B, VAL109A, VAL109B, VAL114A, VAL114B, VAL211A, VAL211B, VAL219A, VAL219B, VAL276A, VAL276B, VAL35A, VAL35B, VAL383A, VAL383B, VAL61A, VAL61B, VAL93A, VAL93B, VAL96A, VAL96B
• A-C: ALA102A, ALA103A, ALA78C, ALA85C, ALA91C, ARG133C, ARG159A, ARG248A, ARG73C, ARG87C, ARG94C, ASN156A, ASN333A, ASN77C, ASN92C, ASP134C, ASP74C, CYS119C, GLN161C, GLN247A, GLU158A, GLU163C, GLU180A, GLU244A, GLU250A, GLU340A, GLU75C, GLU98A, GLY118C, GLY157A, GLY298A, GLY299A, GLY336A, GLY88C, HIS152A, HIS155A, HIS178A, LEU117C, LEU121C, LEU177A, LEU243A, LEU301A, LEU86C, LEU89C, LYS124C, LYS138C, LYS302A, LYS69C, LYS82C, LYS84C, MET334A, PRO101A, PRO122C, PRO162C, PRO338A, PRO90C, SER104A, SER130C, SER154A, SER295A, SER300A, SER81C, THR120C, THR128C, THR339A, THR72C, THR95C, TRP150A, TRP186A, TYR149C, TYR151A, TYR153A, VAL93C
• A-D: ALA102A, ALA102D, ALA103A, ALA103D, ALA99A, ALA99D, CYS389A, CYS389D, GLU250A, GLU250D, LEU100A, LEU100D, LYS302D, PRO101A, PRO101D, SER104A, SER104D, THR251A, THR251D
• A-I: ALA102I, ALA103I, ALA78A, ALA85A, ALA91A, ARG133A, ARG159I, ARG231I, ARG248I, ARG73A, ARG87A, ARG94A, ASN156I, ASN333I, ASN77A, ASN92A, ASP134A, ASP165A, ASP74A, CYS119A, GLN161A, GLN247I, GLU158I, GLU163A, GLU180I, GLU240I, GLU244I, GLU250I, GLU340I, GLU75A, GLU98I, GLY118A, GLY157I, GLY298I, GLY299I, GLY336I, GLY88A, HIS105I, HIS152I, HIS155I, HIS178I, HIS67A, LEU117A, LEU121A, LEU177I, LEU243I, LEU301I, LEU86A, LEU89A, LYS124A, LYS138A, LYS302I, LYS69A, LYS82A, LYS84A, MET334I, PRO101I, PRO106I, PRO122A, PRO162A, PRO338I, PRO90A, SER104I, SER130A, SER154I, SER295I, SER300I, SER81A, THR120A, THR128A, THR251I, THR339I, THR72A, THR95A, TRP150I, TRP186I, TYR149A, TYR151I, TYR153I, VAL129A, VAL93A
• A-J: GLU125A, GLU125J, GLY126A, GLY126J, HIS127A, HIS127J, LYS124A, LYS124J, PRO122A, PRO122J, THR128A, THR128J
• B-C: GLU125B, GLU125C, GLY126B, GLY126C, LYS124B, LYS124C, PRO122B, PRO122C
• B-D: ALA102D, ALA103D, ALA78B, ALA85B, ALA91B, ARG133B, ARG159B, ARG159D, ARG248D, ARG73B, ARG87B, ARG94B, ASN156D, ASN333D, ASN77B, ASN92B, ASP134B, ASP165B, ASP74B, CYS119B, GLN161B, GLN247D, GLU158D, GLU163B, GLU180D, GLU244D, GLU250D, GLU340D, GLU75B, GLU98D, GLY118B, GLY157D, GLY298D, GLY299D, GLY336D, GLY68B, GLY88B, HIS152D, HIS155D, HIS178D, HIS67B, ILE160B, LEU117B, LEU121B, LEU177D, LEU301D, LEU86B, LEU89B, LYS124B, LYS138B, LYS302D, LYS69B, MET334D, PRO101D, PRO122B, PRO162B, PRO338D, PRO90B, SER104D, SER130B, SER154D, SER295D, SER300D, SER81B, THR120B, THR128B, THR339D, THR72B, THR95B, TRP150D, TRP186D, TYR149B, TYR151D, TYR153D, VAL93B
• B-I: ALA102B, ALA102I, ALA103B, ALA103I, ALA99B, ALA99I, CYS389I, LEU100B, LEU100I, LYS302B, PRO101B, PRO101I, SER104B, SER104I, THR251B
• B-J: ALA102B, ALA103B, ALA78J, ALA85J, ALA91J, ARG133J, ARG159B, ARG248B, ARG73J, ARG87J, ARG94J, ASN156B, ASN333B, ASN77J, ASN92J, ASP134J, ASP74J, CYS119J, GLN161J, GLN247B, GLU158B, GLU163J, GLU240B, GLU244B, GLU250B, GLU340B, GLU75J, GLU98B, GLY118J, GLY157B, GLY298B, GLY299B, GLY336B, GLY88J, HIS152B, HIS155B, HIS178B, HIS63J, HIS67J, LEU117J, LEU121J, LEU177B, LEU243B, LEU301B, LEU86J, LEU89J, LYS124J, LYS138J, LYS302B, LYS69J, LYS82J, MET334B, PRO101B, PRO122J, PRO162J, PRO338B, PRO90J, SER104B, SER130J, SER154B, SER295B, SER300B, SER81J, THR120J, THR128J, THR339B, THR72J, TRP150B, TRP186B, TYR149J, TYR151B, TYR153B, VAL129J, VAL93J
• C-D: ALA102C, ALA103C, ALA103D, ALA116C, ALA116D, ALA204C, ALA204D, ALA213C, ALA213D, ALA222C, ALA222D, ALA226C, ALA226D, ALA229C, ALA229D, ALA27C, ALA31C, ALA31D, ALA372C, ALA372D, ALA53C, ALA53D, ALA91C, ALA91D, ALA99C, ALA99D, ARG111C, ARG111D, ARG210C, ARG210D, ARG231C, ARG231D, ARG362C, ARG362D, ARG380C, ARG380D, ARG388C, ARG388D, ARG45C, ARG45D, ARG73C, ARG73D, ARG94C, ARG94D, ASN203C, ASN203D, ASN29C, ASN29D, ASN365C, ASN365D, ASN373C, ASN373D, ASN77C, ASN77D, ASN92C, ASN92D, ASP108C, ASP108D, ASP218C, ASP218D, ASP364C, ASP364D, ASP379C, ASP379D, ASP386C, ASP386D, ASP387C, ASP387D, ASP41C, ASP41D, ASP48C, ASP48D, ASP51C, ASP51D, ASP74C, ASP74D, CYS119C, CYS119D, CYS33C, CYS33D, CYS389D, CYS56C, CYS56D, GLN361C, GLN361D, GLU123C, GLU123D, GLU125C, GLU125D, GLU201C, GLU201D, GLU360C, GLU360D, GLU378C, GLU378D, GLU54C, GLU54D, GLU57C, GLU57D, GLU59C, GLU60C, GLU60D, GLU75C, GLU75D, GLU98C, GLU98D, GLY113C, GLY113D, GLY118C, GLY118D, GLY214C, GLY214D, GLY216C, GLY216D, GLY225C, GLY225D, GLY228C, GLY228D, GLY232C, GLY232D, GLY236C, GLY236D, GLY237C, GLY237D, GLY28C, GLY28D, GLY376C, GLY376D, GLY46C, GLY46D, GLY68C, GLY68D, HIS105C, HIS105D, HIS127C, HIS127D, HIS235C, HIS235D, HIS357C, HIS357D, HIS43C, HIS43D, HIS55C, HIS55D, HIS63C, HIS63D, ILE212C, ILE212D, ILE223C, ILE223D, ILE224C, ILE224D, ILE227C, ILE227D, ILE367D, ILE385C, ILE385D, LEU100C, LEU100D, LEU117C, LEU117D, LEU121C, LEU121D, LEU139C, LEU230C, LEU230D, LEU32C, LEU32D, LEU42C, LEU42D, LEU50C, LEU50D, LEU52C, LEU52D, LEU64C, LEU64D, LEU70C, LEU70D, LEU76C, LEU76D, LEU97C, LEU97D, LYS124C, LYS124D, LYS234C, LYS234D, LYS366C, LYS366D, LYS37C, LYS37D, LYS69C, LYS69D, LYS80C, MET107C, MET107D, MET110C, MET110D, PHE202C, PHE202D, PHE207C, PHE207D, PHE382C, PHE382D, PRO101C, PRO101D, PRO106C, PRO106D, PRO122C, PRO122D, PRO233C, PRO233D, PRO26C, PRO275D, PRO370C, PRO377C, PRO377D, PRO381C, PRO381D, PRO71C, PRO71D, SER104C, SER104D, SER115C, SER115D, SER205C, SER205D, SER209C, SER209D, SER217C, SER217D, SER221C, SER221D, SER371C, SER384C, SER384D, SER38C, SER38D, THR112C, THR112D, THR120C, THR120D, THR206C, THR206D, THR208C, THR208D, THR215C, THR215D, THR30C, THR30D, THR34C, THR34D, THR375C, THR375D, THR72C, THR72D, THR95C, THR95D, TRP150C, TRP150D, TYR220C, TYR220D, TYR374C, TYR374D, TYR44C, TYR44D, TYR47C, TYR47D, VAL109C, VAL109D, VAL114C, VAL114D, VAL211C, VAL211D, VAL219C, VAL219D, VAL35C, VAL35D, VAL383C, VAL383D, VAL61C, VAL61D, VAL93C, VAL93D, VAL96C, VAL96D
• C-E: ALA102C, ALA103C, ALA78E, ALA85E, ALA91E, ARG159C, ARG248C, ARG73E, ARG87E, ARG94E, ASN156C, ASN333C, ASN77E, ASN92E, ASP134E, ASP74E, CYS119E, GLN161E, GLN247C, GLU158C, GLU163E, GLU180C, GLU244C, GLU250C, GLU340C, GLU75E, GLU98C, GLY118E, GLY157C, GLY179C, GLY298C, GLY299C, GLY336C, GLY88E, HIS152C, HIS155C, HIS178C, HIS63E, ILE160E, LEU117E, LEU121E, LEU177C, LEU301C, LEU70E, LEU86E, LEU89E, LYS124E, LYS138E, LYS302C, LYS69E, LYS84E, MET334C, PRO101C, PRO122E, PRO162E, PRO338C, PRO71E, PRO90E, SER104C, SER130E, SER154C, SER300C, SER81E, THR120E, THR128E, THR339C, THR72E, THR95E, TRP150C, TRP186C, TYR149E, TYR151C, TYR153C, VAL93E
• C-F: ALA102C, ALA102F, ALA103C, ALA103F, ALA99C, ALA99F, CYS389F, GLU250C, LEU100C, LEU100F, PRO101C, PRO101F, SER104C, SER104F, THR251C
• D-E: GLU125D, GLU125E, GLY126D, GLY126E, LYS124D, LYS124E, PRO122D, PRO122E
• D-F: ALA102F, ALA103F, ALA78D, ALA85D, ALA91D, ARG133D, ARG159F, ARG248F, ARG73D, ARG87D, ARG94D, ASN156F, ASN333F, ASN77D, ASN92D, ASP134D, ASP165D, ASP74D, CYS119D, GLN161D, GLN247F, GLU158F, GLU163D, GLU180F, GLU244F, GLU250F, GLU297F, GLU340F, GLU75D, GLU98F, GLY118D, GLY157F, GLY179F, GLY298F, GLY299F, GLY336F, GLY88D, HIS105F, HIS152F, HIS155F, HIS178F, HIS63D, HIS67D, LEU117D, LEU121D, LEU177F, LEU243F, LEU301F, LEU86D, LEU89D, LYS124D, LYS138D, LYS302F, LYS69D, LYS82D, LYS84D, MET334F, PRO101F, PRO106F, PRO122D, PRO162D, PRO338F, PRO90D, SER104F, SER130D, SER154F, SER295F, SER300F, SER81D, THR120D, THR128D, THR339F, THR72D, THR95D, TRP150F, TRP186F, TYR149D, TYR151F, TYR153F, VAL93D
• E-F: ALA102E, ALA102F, ALA103E, ALA103F, ALA116E, ALA116F, ALA204E, ALA204F, ALA213E, ALA213F, ALA222E, ALA222F, ALA226E, ALA226F, ALA229E, ALA229F, ALA27E, ALA27F, ALA31E, ALA31F, ALA372E, ALA372F, ALA53E, ALA53F, ALA91E, ALA91F, ALA99E, ALA99F, ARG111E, ARG111F, ARG210E, ARG210F, ARG231E, ARG231F, ARG362E, ARG362F, ARG369E, ARG369F, ARG380E, ARG380F, ARG388E, ARG388F, ARG45E, ARG45F, ARG73E, ARG73F, ARG94E, ARG94F, ASN203E, ASN203F, ASN29E, ASN29F, ASN365E, ASN365F, ASN373E, ASN373F, ASN77E, ASN77F, ASN92E, ASN92F, ASP108E, ASP108F, ASP218E, ASP218F, ASP364F, ASP379E, ASP379F, ASP386E, ASP386F, ASP387E, ASP387F, ASP41E, ASP41F, ASP48E, ASP48F, ASP51E, ASP51F, ASP74E, ASP74F, CYS119E, CYS119F, CYS33E, CYS33F, CYS389E, CYS389F, CYS56E, CYS56F, GLN361E, GLN361F, GLU123E, GLU123F, GLU125E, GLU125F, GLU201E, GLU201F, GLU360E, GLU360F, GLU378E, GLU378F, GLU54E, GLU54F, GLU57E, GLU57F, GLU59E, GLU60E, GLU60F, GLU75E, GLU75F, GLU98E, GLU98F, GLY113E, GLY113F, GLY118E, GLY118F, GLY214E, GLY214F, GLY216E, GLY216F, GLY225E, GLY225F, GLY228E, GLY228F, GLY232E, GLY232F, GLY236E, GLY236F, GLY237E, GLY237F, GLY28E, GLY28F, GLY376E, GLY376F, GLY46E, GLY46F, GLY68E, GLY68F, HIS105E, HIS105F, HIS127E, HIS127F, HIS200F, HIS235E, HIS235F, HIS357E, HIS357F, HIS43E, HIS43F, HIS55E, HIS55F, HIS63E, HIS63F, ILE212E, ILE212F, ILE223E, ILE223F, ILE224E, ILE224F, ILE227E, ILE227F, ILE367E, ILE367F, ILE368E, ILE368F, ILE385E, ILE385F, ILE49E, LEU100E, LEU100F, LEU117E, LEU117F, LEU121E, LEU121F, LEU230E, LEU230F, LEU32E, LEU32F, LEU42E, LEU42F, LEU50E, LEU50F, LEU52E, LEU52F, LEU64E, LEU64F, LEU70E, LEU70F, LEU76E, LEU76F, LEU97E, LEU97F, LYS234E, LYS234F, LYS366E, LYS366F, LYS37E, LYS37F, LYS69E, LYS69F, LYS80E, LYS80F, MET107E, MET107F, MET110E, MET110F, PHE202E, PHE202F, PHE207E, PHE207F, PHE382E, PHE382F, PRO101E, PRO101F, PRO122E, PRO122F, PRO233E, PRO233F, PRO26E, PRO26F, PRO275E, PRO275F, PRO370E, PRO370F, PRO377E, PRO377F, PRO381E, PRO381F, PRO71E, PRO71F, SER104E, SER104F, SER115E, SER115F, SER205E, SER205F, SER209E, SER209F, SER217E, SER217F, SER221E, SER221F, SER371E, SER371F, SER384E, SER384F, SER38E, SER38F, THR112E, THR112F, THR120E, THR120F, THR206E, THR206F, THR208E, THR208F, THR215E, THR215F, THR30E, THR30F, THR34E, THR34F, THR375E, THR375F, THR72E, THR72F, THR95E, THR95F, TRP150E, TRP150F, TYR220E, TYR220F, TYR374E, TYR374F, TYR44E, TYR44F, TYR47E, TYR47F, VAL109E, VAL109F, VAL114E, VAL114F, VAL211E, VAL211F, VAL219E, VAL219F, VAL276E, VAL276F, VAL35E, VAL35F, VAL383E, VAL383F, VAL61E, VAL61F, VAL93E, VAL93F, VAL96E, VAL96F
• E-G: ALA102E, ALA103E, ALA78G, ALA85G, ALA91G, ARG133G, ARG159E, ARG248E, ARG73G, ARG87G, ARG94G, ASN156E, ASN333E, ASN77G, ASN92G, ASP134G, ASP74G, CYS119G, GLN161G, GLN247E, GLU158E, GLU163G, GLU180E, GLU240E, GLU244E, GLU250E, GLU296E, GLU297E, GLU340E, GLU75G, GLU98E, GLY118G, GLY157E, GLY298E, GLY299E, GLY336E, GLY68G, GLY88G, HIS152E, HIS155E, HIS178E, HIS63G, HIS67G, LEU117G, LEU121G, LEU177E, LEU243E, LEU301E, LEU76G, LEU86G, LEU89G, LYS124G, LYS138G, LYS302E, LYS69G, LYS82G, MET303E, MET334E, PRO101E, PRO122G, PRO162G, PRO338E, PRO90G, SER104E, SER130G, SER154E, SER295E, SER300E, SER81G, THR120G, THR128G, THR339E, THR72G, THR95G, TRP150E, TRP186E, TYR151E, TYR153E, TYR249E, TYR79G, VAL129G, VAL93G
• E-H: ALA102E, ALA102H, ALA103E, ALA103H, ALA99H, CYS389E, CYS389H, GLU250H, LEU100E, LEU100H, LYS302E, LYS302H, PRO101E, PRO101H, SER104E, SER104H, THR251H
• F-G: GLU125F, GLU125G, GLY126F, GLY126G, HIS127G, LYS124F, LYS124G, PRO122F, PRO122G, THR128F, THR128G
• F-H: ALA102H, ALA103H, ALA78F, ALA85F, ALA91F, ARG133F, ARG159H, ARG231H, ARG248H, ARG73F, ARG87F, ARG94F, ASN156H, ASN333H, ASN77F, ASN92F, ASP134F, ASP165F, ASP74F, CYS119F, GLN161F, GLN247H, GLU158H, GLU163F, GLU180H, GLU240H, GLU244H, GLU250H, GLU297H, GLU340H, GLU75F, GLU98H, GLY118F, GLY157H, GLY298H, GLY299H, GLY336H, GLY68F, GLY88F, HIS105H, HIS152H, HIS155H, HIS178H, HIS63F, HIS67F, LEU117F, LEU121F, LEU177H, LEU243H, LEU301H, LEU76F, LEU86F, LEU89F, LYS124F, LYS138F, LYS302H, LYS69F, LYS82F, LYS84F, MET334H, PRO101H, PRO106H, PRO122F, PRO162F, PRO338H, PRO90F, SER104H, SER130F, SER154H, SER295H, SER300H, SER81F, THR120F, THR128F, THR339H, THR72F, THR95F, TRP150H, TRP186H, TYR151H, TYR153H, VAL129F, VAL93F
• G-H: ALA102G, ALA102H, ALA103G, ALA103H, ALA116G, ALA116H, ALA204G, ALA204H, ALA213G, ALA213H, ALA222G, ALA222H, ALA226G, ALA226H, ALA229G, ALA229H, ALA27G, ALA31G, ALA31H, ALA372G, ALA372H, ALA53G, ALA53H, ALA91G, ALA91H, ALA99G, ALA99H, ARG111G, ARG111H, ARG210G, ARG210H, ARG231G, ARG231H, ARG362G, ARG362H, ARG369G, ARG369H, ARG380G, ARG380H, ARG388G, ARG388H, ARG45G, ARG45H, ARG73G, ARG73H, ARG94G, ARG94H, ASN203G, ASN203H, ASN29G, ASN29H, ASN365G, ASN365H, ASN373G, ASN373H, ASN77G, ASN77H, ASN92G, ASN92H, ASP108G, ASP108H, ASP218G, ASP218H, ASP364G, ASP364H, ASP379G, ASP379H, ASP386G, ASP386H, ASP387G, ASP387H, ASP41G, ASP41H, ASP48G, ASP48H, ASP51G, ASP51H, ASP74G, ASP74H, CYS119G, CYS119H, CYS33G, CYS33H, CYS389G, CYS389H, CYS56G, CYS56H, GLN361G, GLN361H, GLU123G, GLU123H, GLU125G, GLU125H, GLU201G, GLU201H, GLU360G, GLU360H, GLU378G, GLU378H, GLU54G, GLU54H, GLU57G, GLU57H, GLU59G, GLU60G, GLU60H, GLU75G, GLU75H, GLU98G, GLU98H, GLY113G, GLY113H, GLY118G, GLY118H, GLY214G, GLY214H, GLY216G, GLY216H, GLY225G, GLY225H, GLY228G, GLY228H, GLY232G, GLY232H, GLY236G, GLY236H, GLY237G, GLY237H, GLY28G, GLY28H, GLY376G, GLY376H, GLY46G, GLY46H, GLY68G, GLY68H, HIS105G, HIS105H, HIS127G, HIS127H, HIS235G, HIS235H, HIS357G, HIS357H, HIS43G, HIS43H, HIS55G, HIS55H, HIS63G, HIS63H, ILE212G, ILE212H, ILE223G, ILE223H, ILE224G, ILE224H, ILE227G, ILE227H, ILE367H, ILE368G, ILE368H, ILE385G, ILE385H, LEU100G, LEU100H, LEU117G, LEU117H, LEU121G, LEU121H, LEU230G, LEU230H, LEU32G, LEU32H, LEU42G, LEU50G, LEU50H, LEU52G, LEU52H, LEU64G, LEU64H, LEU70G, LEU70H, LEU76G, LEU76H, LEU97G, LEU97H, LYS124G, LYS234G, LYS234H, LYS366G, LYS366H, LYS37G, LYS37H, LYS69G, LYS69H, LYS80G, MET107G, MET107H, MET110G, MET110H, PHE202G, PHE202H, PHE207G, PHE207H, PHE382G, PHE382H, PRO101G, PRO101H, PRO106G, PRO122G, PRO122H, PRO233G, PRO233H, PRO26G, PRO275G, PRO275H, PRO370G, PRO370H, PRO377G, PRO377H, PRO381G, PRO381H, PRO71G, PRO71H, SER104G, SER104H, SER115G, SER115H, SER205G, SER205H, SER209G, SER209H, SER217G, SER217H, SER221G, SER221H, SER371G, SER371H, SER384G, SER384H, SER38G, SER38H, THR112G, THR112H, THR120G, THR120H, THR206G, THR206H, THR208G, THR208H, THR215G, THR215H, THR30G, THR30H, THR34G, THR34H, THR375G, THR375H, THR72G, THR72H, THR95G, THR95H, TRP150G, TRP150H, TYR220G, TYR220H, TYR374G, TYR374H, TYR44G, TYR44H, TYR47G, TYR47H, VAL109G, VAL109H, VAL114G, VAL114H, VAL211G, VAL211H, VAL219G, VAL219H, VAL276G, VAL276H, VAL35G, VAL35H, VAL383G, VAL383H, VAL61G, VAL61H, VAL93G, VAL93H, VAL96G, VAL96H
• G-I: ALA102G, ALA103G, ALA78I, ALA85I, ALA91I, ARG133I, ARG159G, ARG248G, ARG73I, ARG87I, ARG94I, ASN156G, ASN333G, ASN77I, ASN92I, ASP134I, ASP165I, ASP74I, CYS119I, GLN161I, GLN247G, GLU158G, GLU163I, GLU180G, GLU244G, GLU250G, GLU340G, GLU75I, GLU98G, GLY118I, GLY157G, GLY179G, GLY298G, GLY299G, GLY336G, GLY88I, HIS105G, HIS152G, HIS155G, HIS178G, HIS63I, LEU117I, LEU121I, LEU177G, LEU301G, LEU86I, LEU89I, LYS124I, LYS138I, LYS302G, LYS69I, LYS82I, LYS84I, MET334G, PRO101G, PRO106G, PRO122I, PRO162I, PRO338G, PRO90I, SER104G, SER130I, SER154G, SER300G, SER81I, THR120I, THR128I, THR339G, THR72I, THR95I, TRP150G, TRP186G, TYR149I, TYR151G, TYR153G, VAL93I
• G-J: ALA102G, ALA102J, ALA103G, ALA103J, ALA99G, ALA99J, CYS389G, CYS389J, GLU250G, GLU250J, LEU100G, LEU100J, LYS302G, LYS302J, PRO101G, PRO101J, SER104G, SER104J, THR251G, THR251J
• H-I: GLU125H, GLU125I, GLY126H, GLY126I, HIS127H, LYS124H, LYS124I, PRO122H, PRO122I
• H-J: ALA102J, ALA103J, ALA78H, ALA85H, ALA91H, ARG159J, ARG248J, ARG87H, ARG94H, ASN156J, ASN77H, ASN92H, ASP134H, ASP74H, CYS119H, GLN161H, GLN247J, GLU158J, GLU163H, GLU180J, GLU244J, GLU250J, GLU340J, GLU75H, GLU98J, GLY118H, GLY157J, GLY179J, GLY298J, GLY299J, GLY336J, GLY88H, HIS152J, HIS155J, HIS178J, HIS63H, LEU117H, LEU121H, LEU177J, LEU243J, LEU301J, LEU86H, LEU89H, LYS124H, LYS138H, LYS302J, LYS69H, MET334J, PRO101J, PRO122H, PRO162H, PRO338J, PRO90H, SER104J, SER130H, SER154J, SER300J, SER81H, THR120H, THR128H, THR339J, THR72H, THR95H, TRP150J, TRP186J, TYR149H, TYR151J, TYR153J, VAL93H
• I-J: ALA102I, ALA102J, ALA103I, ALA103J, ALA116I, ALA116J, ALA204I, ALA204J, ALA213I, ALA213J, ALA222I, ALA222J, ALA226I, ALA226J, ALA229I, ALA229J, ALA27J, ALA31I, ALA31J, ALA372I, ALA372J, ALA53I, ALA53J, ALA91I, ALA91J, ALA99I, ALA99J, ARG111I, ARG111J, ARG210I, ARG210J, ARG231I, ARG231J, ARG362I, ARG362J, ARG369I, ARG380I, ARG380J, ARG388I, ARG388J, ARG45I, ARG45J, ARG73I, ARG73J, ARG94I, ARG94J, ASN203I, ASN203J, ASN29I, ASN29J, ASN365I, ASN365J, ASN373I, ASN373J, ASN77I, ASN77J, ASN92I, ASN92J, ASP108I, ASP108J, ASP218I, ASP218J, ASP364I, ASP364J, ASP379I, ASP379J, ASP386I, ASP386J, ASP387I, ASP387J, ASP41I, ASP41J, ASP48I, ASP48J, ASP51I, ASP51J, ASP74I, ASP74J, CYS119I, CYS119J, CYS33I, CYS33J, CYS389I, CYS389J, CYS56I, CYS56J, GLN361I, GLN361J, GLU123I, GLU123J, GLU125I, GLU125J, GLU201I, GLU201J, GLU360I, GLU360J, GLU378I, GLU378J, GLU54I, GLU54J, GLU57I, GLU57J, GLU59I, GLU60I, GLU60J, GLU75I, GLU75J, GLU98I, GLU98J, GLY113I, GLY113J, GLY118I, GLY118J, GLY214I, GLY214J, GLY216I, GLY216J, GLY225I, GLY225J, GLY228I, GLY228J, GLY232I, GLY232J, GLY236I, GLY236J, GLY237I, GLY237J, GLY28I, GLY28J, GLY376I, GLY376J, GLY46I, GLY46J, GLY68I, GLY68J, HIS105I, HIS105J, HIS127I, HIS127J, HIS235I, HIS235J, HIS274J, HIS357I, HIS357J, HIS43I, HIS43J, HIS55I, HIS55J, HIS63I, HIS63J, ILE212I, ILE212J, ILE223I, ILE223J, ILE224I, ILE224J, ILE227I, ILE227J, ILE367I, ILE367J, ILE368I, ILE368J, ILE385I, ILE385J, LEU100I, LEU100J, LEU117I, LEU117J, LEU121I, LEU121J, LEU230I, LEU230J, LEU32I, LEU32J, LEU42I, LEU42J, LEU50I, LEU50J, LEU52I, LEU52J, LEU64I, LEU64J, LEU70I, LEU70J, LEU76I, LEU76J, LEU97I, LEU97J, LYS234I, LYS234J, LYS366I, LYS366J, LYS37I, LYS37J, LYS69I, LYS69J, LYS80J, MET107I, MET107J, MET110I, MET110J, PHE202I, PHE202J, PHE207I, PHE207J, PHE382I, PHE382J, PRO101I, PRO101J, PRO106I, PRO106J, PRO122I, PRO122J, PRO233I, PRO233J, PRO26J, PRO275I, PRO275J, PRO370I, PRO377I, PRO377J, PRO381I, PRO381J, PRO71I, PRO71J, SER104I, SER104J, SER115I, SER115J, SER205I, SER205J, SER209I, SER209J, SER217I, SER217J, SER221I, SER221J, SER371I, SER371J, SER384I, SER384J, SER38I, SER38J, THR112I, THR112J, THR120I, THR120J, THR206I, THR206J, THR208I, THR208J, THR215I, THR215J, THR30I, THR30J, THR343J, THR34I, THR34J, THR375I, THR375J, THR72I, THR72J, THR95I, THR95J, TRP150I, TRP150J, TYR220I, TYR220J, TYR374I, TYR374J, TYR44I, TYR44J, TYR47I, TYR47J, VAL109I, VAL109J, VAL114I, VAL114J, VAL211I, VAL211J, VAL219I, VAL219J, VAL276J, VAL35I, VAL35J, VAL383I, VAL383J, VAL61I, VAL61J, VAL93I, VAL93J, VAL96I, VAL96J