3O4Z

tel2 structure and function in the hsp90-dependent maturation of mtor and atr complexes

• Total interactions analyzed: 6
• Total true interactions: 4
• Strongest Interaction:
  • Chains: B-D
  • Int. Res.: 159
  • Norm. En. per Res.: -2.4409
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-C	-8.2246	63.0851	-400.123	-345.2625	158	34	13	17703	2	46	50
A-D	-39.2506	-5.4411	-256.808	-301.4997	203	14	4	12376	3	79	80
B-C	-34.3456	-5.9866	-249.313	-289.6452	192	19	4	12155	3	76	79
B-D	-15.9061	61.7168	-433.911	-388.1004	159	42	13	18556	2	46	51

Interface residues

• A-C: ALA288A, ALA320A, ALA320C, ALA348A, ALA348C, ALA658A, ALA658C, ALA678A, ALA678C, ARG338A, ARG338C, ARG341A, ARG341C, ARG547A, ARG547C, ARG550A, ARG550C, ARG652A, ARG652C, ASN327A, ASN327C, ASN336A, ASN336C, ASN613A, ASN613C, ASN659A, ASN659C, ASN672A, ASN672C, ASN686A, ASN686C, ASP361A, ASP361C, ASP553A, ASP553C, CYS657A, CYS657C, GLN641A, GLN641C, GLU323A, GLU323C, GLU337A, GLU337C, GLU342A, GLU342C, GLU359A, GLU359C, GLU665A, GLU665C, GLU669A, GLU669C, GLU680A, GLU680C, GLU681A, GLU681C, GLY328A, GLY328C, GLY334A, GLY334C, GLY353A, GLY353C, GLY354A, GLY354C, GLY682A, GLY682C, GLY688A, GLY688C, HIS321A, HIS321C, HIS332A, HIS332C, HIS355A, HIS355C, HIS673A, HIS673C, ILE653A, ILE653C, ILE654A, ILE654C, ILE674A, ILE674C, ILE675A, ILE675C, ILE679A, ILE679C, ILE683A, ILE683C, LEU326A, LEU326C, LEU333A, LEU333C, LEU356A, LEU356C, LEU552A, LEU552C, LEU648A, LEU648C, LEU670A, LEU670C, LEU685A, LEU685C, LYS331A, LYS331C, LYS349A, LYS349C, LYS357A, LYS357C, LYS687A, LYS687C, MET345A, MET345C, MET667A, MET667C, MET671A, MET671C, PHE290A, PHE290C, PHE325A, PHE362A, PHE362C, PHE615A, PHE615C, PHE623A, PHE623C, PHE664A, PHE664C, PRO660A, PRO660C, SER335A, SER335C, SER352A, SER352C, SER360A, SER360C, SER645A, SER645C, SER656A, SER656C, SER676A, SER676C, SER677A, SER677C, SER684A, SER684C, THR330A, THR330C, THR649A, THR649C, THR668A, THR668C, TRP630A, TRP630C, TYR358A, TYR358C, TYR655A, TYR655C, VAL329A, VAL329C
• A-D: ALA124A, ALA124D, ALA136A, ALA136D, ALA142A, ALA142D, ALA470A, ALA470D, ARG138A, ARG138D, ARG215A, ARG215D, ARG616A, ARG616D, ARG76A, ARG76D, ARG88A, ARG88D, ASN133A, ASN133D, ASN137A, ASN137D, ASN178A, ASN178D, ASN519A, ASN519D, ASN523A, ASN523D, ASN659A, ASN659D, ASP140A, ASP140D, ASP289A, ASP289D, ASP292A, ASP292D, ASP296A, ASP296D, ASP439A, ASP439D, ASP663A, ASP663D, GLN468A, GLN468D, GLN473A, GLN473D, GLN481A, GLN481D, GLN91A, GLN91D, GLU257A, GLU257D, GLU293A, GLU293D, GLU294A, GLU294D, GLU443A, GLU443D, GLU445A, GLU445D, GLU475A, GLU475D, GLU516A, GLU516D, GLU51A, GLU51D, GLU665A, GLU665D, GLU92A, GLU92D, GLU95A, GLY128A, GLY128D, GLY146A, GLY477A, GLY477D, GLY482A, GLY482D, HIS662A, HIS662D, ILE139A, ILE139D, ILE78A, ILE78D, ILE87A, ILE87D, LEU125A, LEU125D, LEU131A, LEU131D, LEU135A, LEU135D, LEU145A, LEU145D, LEU150A, LEU150D, LEU176A, LEU176D, LEU177A, LEU177D, LEU181A, LEU181D, LEU252A, LEU252D, LEU474A, LEU474D, LEU84A, LEU84D, LYS130A, LYS130D, LYS143A, LYS143D, LYS286A, LYS286D, LYS438A, LYS438D, LYS442A, LYS442D, LYS446A, LYS446D, LYS469A, LYS469D, LYS517A, LYS517D, LYS54A, LYS54D, LYS617A, LYS617D, MET141A, MET141D, MET441A, MET441D, PHE100A, PHE100D, PHE126A, PHE126D, PHE127A, PHE127D, PHE132A, PHE132D, PHE256A, PHE256D, PHE290A, PHE290D, PHE436A, PHE436D, PHE472A, PHE472D, PHE664A, PHE664D, PRO179A, PRO179D, PRO47A, PRO47D, PRO660A, PRO660D, SER129A, SER129D, SER173A, SER173D, SER253A, SER253D, SER450A, SER450D, SER486D, SER48A, SER48D, SER666A, SER666D, SER75A, SER75D, SER99A, SER99D, THR291A, THR291D, THR299A, THR299D, THR77A, THR77D, TYR144A, TYR144D, TYR147A, TYR147D, TYR444A, TYR444D, TYR478A, TYR478D, TYR479A, TYR479D, TYR624A, TYR624D, VAL134A, VAL134D, VAL180A, VAL180D, VAL295A, VAL295D, VAL435A, VAL435D, VAL476A, VAL476D, VAL661A, VAL661D
• B-C: ALA124C, ALA136B, ALA136C, ALA142B, ALA142C, ALA470B, ALA470C, ARG138B, ARG138C, ARG215B, ARG215C, ARG616B, ARG616C, ARG76B, ARG76C, ARG88B, ARG88C, ASN133B, ASN133C, ASN137B, ASN137C, ASN178B, ASN178C, ASN519B, ASN519C, ASN523B, ASN523C, ASN659B, ASN659C, ASP140B, ASP140C, ASP289B, ASP289C, ASP292B, ASP292C, ASP296B, ASP296C, ASP439B, ASP439C, ASP663B, ASP663C, GLN468B, GLN468C, GLN473B, GLN473C, GLN481B, GLN481C, GLN91B, GLN91C, GLU257B, GLU257C, GLU293B, GLU293C, GLU294B, GLU294C, GLU443B, GLU443C, GLU445B, GLU445C, GLU475B, GLU475C, GLU516B, GLU516C, GLU51B, GLU51C, GLU665B, GLU665C, GLU95B, GLY128B, GLY128C, GLY146B, GLY477B, GLY477C, GLY482B, GLY482C, HIS662B, HIS662C, ILE139B, ILE139C, ILE78B, ILE78C, ILE87B, ILE87C, LEU131B, LEU131C, LEU135B, LEU135C, LEU145B, LEU145C, LEU150B, LEU176B, LEU176C, LEU177B, LEU177C, LEU181B, LEU181C, LEU252C, LEU474B, LEU474C, LEU84B, LEU84C, LYS130B, LYS130C, LYS143B, LYS143C, LYS286B, LYS286C, LYS331C, LYS438B, LYS438C, LYS442B, LYS442C, LYS446B, LYS446C, LYS469B, LYS469C, LYS517B, LYS517C, LYS617B, LYS617C, MET141B, MET141C, MET441B, MET441C, PHE126B, PHE126C, PHE127B, PHE127C, PHE132B, PHE132C, PHE256B, PHE256C, PHE290B, PHE290C, PHE436B, PHE436C, PHE472B, PHE472C, PHE664B, PHE664C, PRO179B, PRO179C, PRO47B, PRO47C, PRO660B, PRO660C, SER129B, SER129C, SER173B, SER173C, SER253B, SER253C, SER285C, SER450B, SER450C, SER486C, SER48B, SER48C, SER666B, SER666C, SER75B, SER75C, SER99B, SER99C, THR291B, THR291C, THR299B, THR299C, THR77B, THR77C, TYR144B, TYR144C, TYR147B, TYR147C, TYR444B, TYR444C, TYR478B, TYR478C, TYR479B, TYR479C, VAL134B, VAL134C, VAL180B, VAL180C, VAL295B, VAL295C, VAL435B, VAL435C, VAL476B, VAL476C, VAL661B, VAL661C
• B-D: ALA288B, ALA320B, ALA320D, ALA348B, ALA348D, ALA658B, ALA658D, ALA678B, ALA678D, ARG338B, ARG338D, ARG341B, ARG341D, ARG547B, ARG547D, ARG550B, ARG550D, ARG652B, ARG652D, ASN327B, ASN327D, ASN336B, ASN336D, ASN613B, ASN613D, ASN659B, ASN659D, ASN672B, ASN672D, ASN686B, ASN686D, ASP361B, ASP361D, ASP553B, ASP553D, CYS657B, CYS657D, GLN641B, GLN641D, GLU323B, GLU323D, GLU337B, GLU337D, GLU342B, GLU342D, GLU359B, GLU359D, GLU665B, GLU665D, GLU669B, GLU669D, GLU680B, GLU680D, GLU681B, GLU681D, GLY328B, GLY328D, GLY334B, GLY334D, GLY353B, GLY353D, GLY354B, GLY354D, GLY682B, GLY682D, GLY688B, GLY688D, HIS321B, HIS321D, HIS332B, HIS332D, HIS355B, HIS355D, HIS673B, HIS673D, ILE653B, ILE653D, ILE654B, ILE654D, ILE674B, ILE674D, ILE675B, ILE675D, ILE679B, ILE679D, ILE683B, ILE683D, LEU326B, LEU326D, LEU333B, LEU333D, LEU356B, LEU356D, LEU552B, LEU552D, LEU648B, LEU648D, LEU670B, LEU670D, LEU685B, LEU685D, LYS331B, LYS331D, LYS349B, LYS349D, LYS357B, LYS357D, LYS687B, LYS687D, MET345B, MET345D, MET667B, MET667D, MET671B, MET671D, PHE290B, PHE290D, PHE325B, PHE325D, PHE362B, PHE362D, PHE615B, PHE615D, PHE623B, PHE623D, PHE664B, PHE664D, PRO660B, PRO660D, SER335B, SER335D, SER352B, SER352D, SER360B, SER360D, SER645B, SER645D, SER656B, SER656D, SER676B, SER676D, SER677B, SER677D, SER684B, SER684D, THR330B, THR330D, THR649B, THR649D, THR668B, THR668D, TRP630B, TRP630D, TYR358B, TYR358D, TYR655B, TYR655D, VAL329B, VAL329D