3O4R

crystal structure of human dehydrogenase/reductase (sdr family) member 4 (dhrs4)

• Total interactions analyzed: 6
• Total true interactions: 6
• Strongest Interaction:
  • Chains: B-D
  • Int. Res.: 154
  • Norm. En. per Res.: -4.0378
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-87.2199	-30.9186	-373.055	-491.1935	145	19	14	17248	6	28	28
A-C	-137.2101	-74.9606	-415.253	-627.4237	161	15	8	15246	11	31	43
A-D	0.0	0.0	-37.4964	-37.4964	43	1	2	2449	0	2	3
B-C	0.0	0.0	-37.7631	-37.7631	45	0	2	2552	0	2	3
B-D	-128.0958	-71.8985	-421.823	-621.8173	154	13	8	15266	11	23	37
C-D	-76.4458	-29.1067	-396.861	-502.4135	148	14	14	17725	7	29	29

Interface residues

• A-B: ALA144A, ALA144B, ALA146A, ALA146B, ALA151A, ALA151B, ALA171A, ALA171B, ALA172A, ALA172B, ALA188A, ALA188B, ALA197A, ALA197B, ALA201A, ALA201B, ALA93A, ALA93B, ARG203A, ARG203B, ARG277A, ARG277B, ARG96A, ARG96B, ASN141A, ASN141B, ASN183A, ASN183B, ASP128A, ASP128B, ASP135A, ASP135B, ASP139A, ASP139B, GLU131A, GLU131B, GLU132A, GLU132B, GLU155A, GLU155B, GLU157A, GLU157B, GLU199A, GLU199B, GLY124A, GLY124B, GLY178A, GLY178B, GLY191A, GLY191B, GLY91A, GLY91B, ILE126A, ILE126B, ILE140A, ILE166A, ILE198A, ILE198B, ILE205A, LEU138A, LEU138B, LEU147A, LEU147B, LEU189A, LEU189B, LEU190A, LEU190B, LEU192A, LEU192B, LEU196A, LEU196B, LEU200A, LEU200B, LEU278A, LEU278B, LYS136A, LYS136B, LYS143A, LYS143B, LYS150A, LYS150B, LYS186A, LYS186B, LYS194A, LYS194B, LYS92A, LYS92B, MET127A, MET127B, PHE173A, PHE173B, PHE179A, PHE179B, PRO145A, PRO145B, PRO154A, PRO154B, PRO175A, PRO175B, PRO177A, PRO177B, PRO181A, PRO181B, PRO202A, PRO202B, SER125A, SER125B, SER174A, SER174B, SER176A, SER176B, SER180A, SER180B, SER185A, SER185B, THR130A, THR130B, THR137A, THR137B, THR149A, THR149B, THR187A, THR187B, THR193A, THR193B, THR195A, THR195B, TRP134A, TRP134B, TYR182A, TYR182B, VAL129A, VAL129B, VAL133A, VAL133B, VAL142A, VAL142B, VAL152A, VAL152B, VAL153A, VAL153B, VAL184A, VAL184B, VAL207A, VAL207B
• A-C: ALA172A, ALA172C, ALA188A, ALA188C, ALA197A, ALA197C, ALA201A, ALA201C, ALA211A, ALA211C, ALA249A, ALA249C, ALA260A, ALA260C, ARG203A, ARG203C, ARG206A, ARG206C, ARG238A, ARG238C, ARG240A, ARG240C, ARG241A, ARG241C, ARG26A, ARG26C, ARG277A, ARG277C, ARG27A, ARG27C, ARG51A, ARG51C, ASN204A, ASN204C, ASN208A, ASN208C, ASP247A, ASP247C, ASP259A, ASP259C, ASP28A, ASP28C, ASP55A, CYS209A, CYS209C, CYS248A, CYS248C, GLN54A, GLN54C, GLU244A, GLU244C, GLU246A, GLU246C, GLU258A, GLU258C, GLU266A, GLU266C, GLY160A, GLY160C, GLY161A, GLY161C, GLY191A, GLY191C, GLY213A, GLY213C, GLY243A, GLY243C, GLY250A, GLY250C, GLY265A, GLY265C, GLY271A, GLY271C, GLY272A, GLY272C, GLY273A, GLY273C, ILE170A, ILE170C, ILE198A, ILE198C, ILE205A, ILE205C, ILE215A, ILE215C, ILE239A, ILE239C, ILE251A, ILE251C, ILE263A, ILE263C, LEU189A, LEU189C, LEU190A, LEU190C, LEU192A, LEU192C, LEU200A, LEU200C, LEU210A, LEU210C, LEU214A, LEU214C, LEU237A, LEU237C, LEU242A, LEU242C, LEU255A, LEU255C, LEU278A, LEU278C, LYS194A, LYS194C, LYS216A, LYS216C, LYS234A, LYS234C, PHE173A, PHE173C, PHE254A, PHE254C, PRO202A, PRO202C, PRO212A, PRO212C, PRO275A, PRO275C, PRO29A, PRO29C, SER253A, SER253C, SER257A, SER257C, SER261A, SER261C, SER276A, SER276C, THR187A, THR187C, THR193A, THR193C, THR195A, THR195C, THR264A, THR264C, THR267A, THR267C, THR274A, THR274C, TYR262A, TYR262C, VAL207A, VAL207C, VAL252A, VAL252C, VAL268A, VAL268C, VAL269A, VAL269C, VAL270A, VAL270C
• A-D: ALA171A, ALA171D, ALA172A, ALA172D, ARG238A, ARG238D, ARG277A, ARG277D, GLU235A, GLU235D, GLY191A, GLY191D, ILE170A, LEU190A, LEU190D, LEU237A, LEU237D, LEU278A, LEU278D, LYS186A, LYS186D, MET233A, MET233D, PHE173A, PHE173D, PRO175A, PRO175D, PRO177A, PRO177D, PRO275A, PRO275D, SER174A, SER174D, SER176A, SER176D, SER276A, SER276D, THR187A, THR187D, THR236A, THR236D, THR274A, THR274D
• B-C: ALA171B, ALA171C, ALA172B, ALA172C, ALA188C, ARG238B, ARG238C, ARG277B, ARG277C, GLU235B, GLU235C, GLY191B, GLY191C, ILE170B, ILE170C, LEU190B, LEU190C, LEU237B, LEU237C, LEU278B, LEU278C, LYS186B, LYS186C, MET233B, MET233C, PHE173B, PHE173C, PRO175B, PRO175C, PRO177B, PRO177C, PRO275B, PRO275C, SER174B, SER174C, SER176B, SER176C, SER276B, SER276C, THR187B, THR187C, THR236B, THR236C, THR274B, THR274C
• B-D: ALA172B, ALA172D, ALA188B, ALA188D, ALA197B, ALA197D, ALA201B, ALA201D, ALA211B, ALA211D, ALA249B, ALA249D, ALA260B, ALA260D, ARG203B, ARG203D, ARG206B, ARG206D, ARG238B, ARG238D, ARG240B, ARG240D, ARG241B, ARG241D, ARG277B, ARG277D, ARG51B, ARG51D, ASN204B, ASN204D, ASN208B, ASN208D, ASP247B, ASP247D, ASP259B, ASP259D, ASP55B, ASP55D, CYS209B, CYS209D, CYS248B, CYS248D, GLU244B, GLU244D, GLU246B, GLU246D, GLU258B, GLU258D, GLU266B, GLU266D, GLY160B, GLY160D, GLY161B, GLY161D, GLY191B, GLY191D, GLY213B, GLY213D, GLY243B, GLY243D, GLY250B, GLY250D, GLY265B, GLY265D, GLY271B, GLY271D, GLY272B, GLY272D, GLY273B, GLY273D, ILE170B, ILE170D, ILE198B, ILE198D, ILE205B, ILE205D, ILE215B, ILE215D, ILE239B, ILE239D, ILE251B, ILE251D, ILE263B, ILE263D, LEU189B, LEU189D, LEU190B, LEU190D, LEU192B, LEU192D, LEU200B, LEU200D, LEU210B, LEU210D, LEU214B, LEU214D, LEU237B, LEU237D, LEU242B, LEU242D, LEU255B, LEU255D, LEU278B, LEU278D, LYS194B, LYS194D, LYS216B, LYS216D, LYS234B, LYS234D, PHE173B, PHE173D, PHE254B, PHE254D, PRO202B, PRO202D, PRO212B, PRO212D, PRO275B, PRO275D, PRO29B, PRO29D, SER253B, SER253D, SER257B, SER257D, SER261B, SER261D, SER276B, SER276D, THR187B, THR187D, THR193B, THR193D, THR195B, THR195D, THR264B, THR264D, THR267B, THR267D, THR274B, THR274D, TYR262B, TYR262D, VAL207B, VAL207D, VAL252B, VAL252D, VAL268B, VAL268D, VAL269B, VAL269D, VAL270B, VAL270D
• C-D: ALA144C, ALA144D, ALA146C, ALA146D, ALA151C, ALA151D, ALA171C, ALA171D, ALA172C, ALA172D, ALA188C, ALA188D, ALA197C, ALA197D, ALA201C, ALA201D, ALA93C, ALA93D, ARG203C, ARG203D, ARG277C, ARG277D, ARG96C, ARG96D, ASN141C, ASN141D, ASN183C, ASN183D, ASP128C, ASP128D, ASP135C, ASP135D, ASP139C, ASP139D, GLU131C, GLU131D, GLU132C, GLU132D, GLU155C, GLU155D, GLU157C, GLU157D, GLU199C, GLU199D, GLU97D, GLY124C, GLY124D, GLY178C, GLY178D, GLY191C, GLY191D, GLY91C, GLY91D, ILE126C, ILE126D, ILE140C, ILE140D, ILE166C, ILE198C, ILE198D, LEU138C, LEU138D, LEU147C, LEU147D, LEU189C, LEU189D, LEU190C, LEU190D, LEU192C, LEU192D, LEU196C, LEU196D, LEU200C, LEU200D, LEU278C, LEU278D, LYS136C, LYS136D, LYS143C, LYS143D, LYS150C, LYS150D, LYS186C, LYS186D, LYS194C, LYS194D, LYS92C, LYS92D, MET127C, MET127D, PHE123C, PHE123D, PHE173C, PHE173D, PHE179C, PHE179D, PRO145C, PRO145D, PRO154C, PRO154D, PRO175C, PRO175D, PRO177C, PRO177D, PRO181C, PRO181D, PRO202C, PRO202D, SER125C, SER125D, SER174C, SER174D, SER176C, SER176D, SER180C, SER180D, SER185C, SER185D, THR130C, THR130D, THR137C, THR137D, THR149C, THR149D, THR187C, THR187D, THR193C, THR193D, THR195C, THR195D, TRP134C, TRP134D, TYR182C, TYR182D, VAL129C, VAL129D, VAL133C, VAL133D, VAL142C, VAL142D, VAL152C, VAL152D, VAL153C, VAL153D, VAL184C, VAL184D, VAL207C, VAL207D