3O44

crystal structure of the vibrio cholerae cytolysin (hlya) heptameric pore

• Total interactions analyzed: 91
• Total true interactions: 30
• Strongest Interaction:
  • Chains: I-J
  • Int. Res.: 273
  • Norm. En. per Res.: -4.4415
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-349.4536	21.0626	-861.219	-1189.6101	272	59	17	30200	1	59	68
A-C	0.0	0.0	-1.3451	-1.3451	13	0	0	128	0	8	5
A-F	0.0	0.0	-1.1485	-1.1485	13	0	0	125	0	8	5
A-G	-305.0857	20.6488	-835.794	-1120.231	267	59	18	30207	1	61	68
A-I	-33.2138	-28.2852	-209.426	-270.925	138	16	0	10119	3	34	34
A-J	0.0	9.3295	-21.7669	-12.4374	30	1	1	941	0	13	13
B-C	-319.6636	25.7843	-814.517	-1108.3963	270	52	18	29825	1	58	68
B-D	0.0	0.0	-1.2131	-1.2131	12	0	0	116	0	8	5
B-G	0.0	0.0	-1.2612	-1.2612	13	0	0	122	0	8	5
B-I	0.0	14.3282	-15.8533	-1.5251	25	0	1	762	0	10	9
B-J	0.0	-6.4472	-64.9911	-71.4383	88	0	0	3967	0	13	16
C-D	-249.3453	23.9475	-751.934	-977.3318	264	49	17	29009	1	58	67
C-E	0.0	0.0	-0.963	-0.963	12	0	0	106	0	8	5
D-E	-339.1586	20.9209	-839.493	-1157.7307	268	61	17	29794	1	59	68
D-F	0.0	0.0	-1.678	-1.678	14	0	0	158	0	8	7
D-G	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
E-F	-338.8698	23.3375	-836.921	-1152.4533	271	49	18	29769	1	59	68
E-G	0.0	0.0	-1.4795	-1.4795	13	0	0	147	0	8	7
F-G	-282.9861	22.9771	-765.906	-1025.915	268	47	18	29182	1	59	68
H-I	-237.9373	23.7144	-754.251	-968.4738	260	49	18	28986	1	58	67
H-J	0.0	0.0	-0.9503	-0.9503	12	0	0	108	0	8	5
H-N	-275.5495	30.4353			66
I-J	-357.1848	23.0455	-878.396	-1212.5353	273	77	16	30403	2	61	68
I-K	0.0	0.0	-1.5099	-1.5099	16	0	0	148	0	8	6
I-L	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
J-K	-333.9046	13.1294	-816.73	-1137.5052	271	49	17	29473	1	59	68
J-L	0.0	0.0	-1.352	-1.352	12	0	0	135	0	8	6
K-L	-231.7024	13.2877	-628.054	-846.4687	217	44	13	23871	1	56	60
L-M	-295.1156	21.3503			68
M-N	-396.2156	25.4883			64

Interface residues

• A-B: ALA143B, ALA151B, ALA178B, ALA200A, ALA204A, ALA218B, ALA265A, ALA305A, ALA305B, ALA309A, ALA309B, ALA311A, ALA311B, ALA332A, ALA335A, ALA337A, ALA348A, ALA348B, ALA379B, ALA391A, ALA393A, ALA466B, ALA516A, ALA576B, ALA583B, ARG150B, ARG185B, ARG208B, ARG255A, ARG282A, ARG282B, ARG310A, ARG310B, ARG317A, ARG317B, ARG327A, ARG327B, ARG330A, ARG344B, ARG372B, ARG459B, ARG471B, ARG502A, ARG531A, ARG572B, ASN149B, ASN179B, ASN187B, ASN223B, ASN263A, ASN275A, ASN277A, ASN322B, ASN331A, ASN334A, ASN343A, ASN343B, ASN371B, ASN462B, ASN469B, ASN470B, ASN525A, ASN527A, ASN543A, ASN582B, ASP177B, ASP203A, ASP212B, ASP213B, ASP214B, ASP224B, ASP274A, ASP301A, ASP301B, ASP325B, ASP369B, ASP487B, ASP514A, ASP539B, ASP579B, CYS472B, CYS486B, CYS524A, GLN225B, GLN266A, GLN315A, GLN315B, GLN324B, GLN336A, GLN345A, GLN345B, GLN346A, GLN346B, GLN464B, GLN489B, GLN490B, GLN493B, GLN499A, GLN526A, GLN530A, GLU189B, GLU278A, GLU281A, GLU281B, GLU284A, GLU289A, GLU289B, GLU297A, GLU297B, GLU308A, GLU308B, GLU329A, GLU533A, GLU585B, GLY195A, GLY198A, GLY217B, GLY219B, GLY287A, GLY287B, GLY291A, GLY291B, GLY294A, GLY295A, GLY295B, GLY300A, GLY302A, GLY302B, GLY515A, GLY547A, HIS141B, HIS221B, HIS552B, ILE146B, ILE180B, ILE183B, ILE196A, ILE206A, ILE220B, ILE267A, ILE276A, ILE328A, ILE328B, ILE373B, ILE388A, ILE574B, LEU139B, LEU182B, LEU188B, LEU192A, LEU211B, LEU222B, LEU268A, LEU290A, LEU290B, LEU307A, LEU307B, LEU319A, LEU319B, LEU376B, LEU465B, LEU500A, LEU528A, LYS176B, LYS205A, LYS269A, LYS279A, LYS283A, LYS283B, LYS304A, LYS304B, LYS306A, LYS306B, LYS333A, LYS384B, LYS390A, MET485B, PHE144B, PHE271A, PHE280A, PHE280B, PHE288A, PHE288B, PHE340A, PHE381B, PHE468B, PHE581B, PRO140B, PRO202A, PRO272A, PRO303A, PRO303B, PRO375B, PRO383B, PRO460B, SER147B, SER181B, SER191A, SER199A, SER215B, SER286A, SER286B, SER299A, SER312A, SER312B, SER316A, SER316B, SER339A, SER352B, SER374B, SER377B, SER380B, SER392A, SER467B, SER488B, SER546A, THR136B, THR138B, THR201A, THR216B, THR270A, THR293A, THR293B, THR314A, THR314B, THR320A, THR320B, THR323A, THR323B, THR341A, THR349A, THR394A, THR529A, THR542A, THR573B, THR575B, THR578B, TRP318A, TRP318B, TRP342B, TYR145B, TYR184B, TYR313A, TYR313B, TYR321A, TYR321B, TYR326B, TYR347A, TYR347B, TYR378B, TYR389A, TYR545A, TYR577B, VAL142B, VAL148B, VAL186B, VAL197A, VAL273A, VAL285A, VAL285B, VAL292A, VAL292B, VAL296A, VAL296B, VAL298A, VAL338A, VAL370B, VAL382B, VAL387A, VAL454B, VAL544A, VAL580B
• A-C: ARG282A, ARG372C, ASN355C, ASN371C, ASP369C, GLN315A, GLU284A, LYS283A, SER357C, THR320C, TRP318C, TYR313A, TYR347C
• A-F: ARG282F, ARG372A, ASN355A, ASN371A, ASP369A, GLN315F, GLU284F, LYS283F, SER357A, THR320A, TRP318A, TYR313F, TYR347A
• A-G: ALA143A, ALA151A, ALA178A, ALA200G, ALA204G, ALA218A, ALA265G, ALA305A, ALA309A, ALA311A, ALA311G, ALA332G, ALA335G, ALA337G, ALA348A, ALA348G, ALA379A, ALA391G, ALA393G, ALA466A, ALA516G, ALA576A, ALA583A, ARG150A, ARG185A, ARG208A, ARG255G, ARG282A, ARG282G, ARG310A, ARG310G, ARG317A, ARG317G, ARG327A, ARG327G, ARG330G, ARG344A, ARG372A, ARG459A, ARG471A, ARG502G, ARG531G, ARG572A, ASN149A, ASN179A, ASN187A, ASN223A, ASN263G, ASN275G, ASN277G, ASN322A, ASN331G, ASN334G, ASN343A, ASN343G, ASN371A, ASN462A, ASN469A, ASN470A, ASN525G, ASN527G, ASN543G, ASN582A, ASP177A, ASP203G, ASP212A, ASP213A, ASP214A, ASP224A, ASP274G, ASP301A, ASP301G, ASP325A, ASP369A, ASP487A, ASP514G, ASP539A, ASP579A, CYS472A, CYS486A, CYS524G, GLN225A, GLN266G, GLN315A, GLN315G, GLN324A, GLN336G, GLN345A, GLN345G, GLN346A, GLN346G, GLN464A, GLN489A, GLN490A, GLN493A, GLN499G, GLN526G, GLN530G, GLU189A, GLU278G, GLU281A, GLU281G, GLU284G, GLU289A, GLU289G, GLU297A, GLU297G, GLU308A, GLU308G, GLU329G, GLU533G, GLU585A, GLY195G, GLY198G, GLY217A, GLY219A, GLY287A, GLY287G, GLY291A, GLY291G, GLY294G, GLY295A, GLY295G, GLY300G, GLY302A, GLY302G, GLY515G, GLY547G, HIS141A, HIS221A, HIS552A, ILE146A, ILE180A, ILE183A, ILE196G, ILE206G, ILE220A, ILE267G, ILE276G, ILE328A, ILE328G, ILE373A, ILE388G, ILE574A, LEU139A, LEU182A, LEU188A, LEU192G, LEU211A, LEU222A, LEU268G, LEU290G, LEU307A, LEU307G, LEU319A, LEU319G, LEU376A, LEU465A, LEU500G, LEU528G, LYS176A, LYS205G, LYS269G, LYS279G, LYS283A, LYS283G, LYS304A, LYS304G, LYS306A, LYS306G, LYS333G, LYS384A, LYS390G, MET485A, PHE144A, PHE271G, PHE280A, PHE280G, PHE288A, PHE288G, PHE340G, PHE381A, PHE468A, PHE581A, PRO140A, PRO202G, PRO272G, PRO303A, PRO375A, PRO383A, PRO460A, SER147A, SER181A, SER191G, SER199G, SER215A, SER286A, SER286G, SER299G, SER312A, SER312G, SER316A, SER316G, SER339G, SER352A, SER374A, SER377A, SER380A, SER392G, SER467A, SER488A, SER546G, THR136A, THR138A, THR201G, THR216A, THR270G, THR293A, THR293G, THR314A, THR314G, THR320A, THR320G, THR323A, THR323G, THR341G, THR349G, THR394G, THR529G, THR542G, THR573A, THR575A, THR578A, TRP318A, TRP318G, TRP342A, TYR145A, TYR184A, TYR313A, TYR313G, TYR321A, TYR321G, TYR326A, TYR347A, TYR347G, TYR378A, TYR389G, TYR545G, TYR577A, VAL142A, VAL148A, VAL186A, VAL197G, VAL273G, VAL285A, VAL285G, VAL292A, VAL292G, VAL296G, VAL298G, VAL338G, VAL370A, VAL382A, VAL387G, VAL454A, VAL544G, VAL580A
• A-I: ALA477A, ALA477I, ALA618A, ALA622A, ALA622I, ARG480A, ARG601A, ARG601I, ARG607A, ARG607I, ARG611A, ARG611I, ARG670I, ASN262A, ASN262I, ASN508A, ASN508I, ASN598A, ASN598I, ASN606A, ASN606I, ASN630A, ASN630I, ASN716A, ASN716I, ASP400A, ASP400I, ASP449A, ASP449I, ASP451A, ASP451I, ASP476A, ASP476I, ASP605A, ASP605I, ASP624A, ASP624I, ASP638A, ASP638I, ASP714I, GLN478A, GLN478I, GLN599A, GLN599I, GLN600A, GLN600I, GLN604A, GLN604I, GLN671A, GLN672A, GLN672I, GLN698A, GLN698I, GLU395A, GLU395I, GLY397A, GLY397I, GLY479A, GLY479I, GLY603A, GLY603I, GLY620A, GLY620I, GLY629A, GLY629I, GLY631A, GLY631I, GLY632A, GLY632I, ILE696A, ILE696I, LEU511A, LEU511I, LEU608I, LEU625A, LEU625I, LEU626A, LEU626I, LEU634A, LEU634I, LEU639A, LEU639I, LEU699A, LEU699I, LYS264A, LYS264I, LYS510A, LYS510I, LYS695A, LYS695I, LYS700A, LYS700I, PRO523A, SER392I, SER398A, SER398I, SER507A, SER507I, SER621A, SER621I, SER623A, SER623I, SER633A, SER633I, SER635A, SER635I, SER636A, SER636I, SER640A, SER640I, THR394A, THR394I, THR396A, THR396I, THR399A, THR399I, THR447A, THR447I, THR673A, THR673I, THR697A, THR697I, TRP450A, TRP450I, TYR609A, TYR609I, TYR666A, TYR666I, VAL448A, VAL448I, VAL602A, VAL602I, VAL610A, VAL610I, VAL637A, VAL637I, VAL674A, VAL674I
• A-J: ALA614A, ALA693J, ALA694J, ARG687J, ASP617A, ASP651A, ASP668J, ASP689J, ASP692J, ASP704A, ASP705A, GLN594A, GLN653A, GLN657A, GLN658A, GLN667J, GLY631A, GLY641J, GLY655A, GLY656A, GLY669J, LEU690J, LEU707A, LYS643J, LYS709A, PHE652A, PRO691J, TRP706A, TYR654A, TYR666J
• B-C: ALA143C, ALA151C, ALA178C, ALA200B, ALA204B, ALA218C, ALA265B, ALA305B, ALA305C, ALA309B, ALA309C, ALA311B, ALA311C, ALA332B, ALA335B, ALA337B, ALA348B, ALA348C, ALA379C, ALA391B, ALA393B, ALA466C, ALA516B, ALA576C, ALA583C, ARG150C, ARG185C, ARG208C, ARG255B, ARG282B, ARG282C, ARG310B, ARG310C, ARG317B, ARG317C, ARG327B, ARG327C, ARG330B, ARG344C, ARG372C, ARG459C, ARG471C, ARG502B, ARG531B, ARG572C, ASN149C, ASN179C, ASN187C, ASN223C, ASN263B, ASN275B, ASN277B, ASN322C, ASN331B, ASN334B, ASN343B, ASN343C, ASN371C, ASN462C, ASN469C, ASN470C, ASN525B, ASN527B, ASN543B, ASN582C, ASP177C, ASP203B, ASP212C, ASP213C, ASP214C, ASP224C, ASP274B, ASP301B, ASP301C, ASP325C, ASP369C, ASP487C, ASP514B, ASP539C, ASP579C, CYS472C, CYS486C, CYS524B, GLN225C, GLN266B, GLN315B, GLN315C, GLN324C, GLN336B, GLN345B, GLN345C, GLN346B, GLN346C, GLN464C, GLN489C, GLN490C, GLN493C, GLN499B, GLN526B, GLN530B, GLU189C, GLU278B, GLU281B, GLU281C, GLU284B, GLU289B, GLU289C, GLU297B, GLU297C, GLU308B, GLU308C, GLU329B, GLU533B, GLU585C, GLY195B, GLY198B, GLY217C, GLY219C, GLY287B, GLY287C, GLY291B, GLY291C, GLY294B, GLY295B, GLY295C, GLY300B, GLY302B, GLY302C, GLY515B, GLY547B, HIS141C, HIS221C, HIS552C, ILE146C, ILE180C, ILE183C, ILE196B, ILE206B, ILE220C, ILE267B, ILE276B, ILE328B, ILE328C, ILE373C, ILE388B, ILE574C, LEU139C, LEU182C, LEU188C, LEU192B, LEU211C, LEU222C, LEU268B, LEU290B, LEU307B, LEU307C, LEU319B, LEU319C, LEU376C, LEU465C, LEU500B, LEU528B, LYS176C, LYS205B, LYS269B, LYS279B, LYS283B, LYS283C, LYS304B, LYS304C, LYS306B, LYS306C, LYS333B, LYS384C, LYS390B, MET485C, PHE144C, PHE280B, PHE280C, PHE288B, PHE288C, PHE340B, PHE381C, PHE468C, PHE581C, PRO140C, PRO202B, PRO272B, PRO303B, PRO303C, PRO375C, PRO383C, PRO460C, SER147C, SER181C, SER191B, SER199B, SER215C, SER286B, SER286C, SER299B, SER312B, SER312C, SER316B, SER316C, SER339B, SER352C, SER374C, SER377C, SER380C, SER392B, SER467C, SER488C, SER546B, THR136C, THR138C, THR201B, THR216C, THR270B, THR293B, THR293C, THR314B, THR314C, THR320B, THR320C, THR323B, THR323C, THR341B, THR349B, THR394B, THR529B, THR542B, THR573C, THR575C, THR578C, TRP318B, TRP318C, TRP342C, TYR145C, TYR184C, TYR313B, TYR313C, TYR321B, TYR321C, TYR326C, TYR347B, TYR347C, TYR378C, TYR389B, TYR545B, TYR577C, VAL142C, VAL148C, VAL186C, VAL197B, VAL273B, VAL285B, VAL285C, VAL292B, VAL292C, VAL296B, VAL296C, VAL298B, VAL338B, VAL370C, VAL382C, VAL387B, VAL454C, VAL544B, VAL580C
• B-D: ARG282B, ARG372D, ASN355D, ASN371D, ASP369D, GLN315B, GLU284B, LYS283B, SER357D, TRP318D, TYR313B, TYR347D
• B-G: ARG282G, ARG372B, ASN355B, ASN371B, ASP369B, GLN315G, GLU284G, LYS283G, SER357B, THR320B, TRP318B, TYR313G, TYR347B
• B-I: ALA693B, ARG687B, ASN630I, ASP617I, ASP668B, ASP689B, ASP692B, ASP704I, ASP705I, GLN653I, GLN657I, GLN658I, GLN667B, GLY631I, GLY641B, GLY655I, GLY656I, GLY669B, LEU707I, LYS643B, LYS709I, PHE652I, TRP706I, TYR654I, TYR666B
• B-J: ALA612B, ALA612J, ALA614B, ALA614J, ALA615B, ALA615J, ALA661J, ALA678B, ALA678J, ARG172B, ARG172J, ARG229B, ARG229J, ARG611B, ARG611J, ASN160B, ASN160J, ASN161B, ASN161J, ASN167B, ASN167J, ASP154B, ASP154J, ASP617B, ASP617J, GLN230B, GLN230J, GLN653J, GLN671B, GLN672B, GLN672J, GLU155B, GLU155J, GLU168B, GLU168J, GLY170B, GLY170J, GLY232B, GLY232J, GLY613B, GLY613J, GLY631B, GLY631J, GLY632B, GLY632J, GLY675B, GLY675J, LEU634B, LEU634J, LYS166B, LYS166J, LYS169B, LYS169J, LYS176J, LYS677B, LYS677J, PHE159B, PHE159J, PHE231B, PHE231J, PHE652B, PHE652J, PRO173B, PRO173J, SER162B, SER171B, SER171J, SER234B, SER234J, SER633B, SER633J, SER635B, SER635J, SER676B, SER676J, THR158B, THR158J, THR673B, THR673J, THR681B, THR681J, TYR654B, TYR654J, TYR679B, TYR679J, VAL674B, VAL674J, VAL680J
• C-D: ALA143D, ALA151D, ALA178D, ALA200C, ALA204C, ALA218D, ALA265C, ALA305D, ALA309D, ALA311D, ALA332C, ALA335C, ALA337C, ALA348C, ALA348D, ALA379D, ALA391C, ALA393C, ALA466D, ALA516C, ALA517C, ALA576D, ALA583D, ARG150D, ARG185D, ARG208D, ARG255C, ARG282C, ARG310C, ARG310D, ARG317D, ARG327C, ARG327D, ARG330C, ARG344D, ARG372D, ARG459D, ARG471D, ARG502C, ARG531C, ARG572D, ASN149D, ASN179D, ASN187D, ASN223D, ASN263C, ASN275C, ASN277C, ASN322D, ASN331C, ASN334C, ASN343C, ASN343D, ASN371D, ASN462D, ASN469D, ASN470D, ASN525C, ASN527C, ASN543C, ASN582D, ASP177D, ASP203C, ASP212D, ASP213D, ASP214D, ASP224D, ASP274C, ASP301C, ASP301D, ASP325D, ASP369D, ASP487D, ASP514C, ASP539D, ASP579D, CYS472D, CYS486D, CYS524C, GLN225D, GLN266C, GLN315D, GLN324D, GLN336C, GLN345C, GLN345D, GLN346C, GLN346D, GLN464D, GLN489D, GLN490D, GLN493D, GLN499C, GLN526C, GLN530C, GLU189D, GLU278C, GLU281C, GLU281D, GLU284C, GLU289C, GLU289D, GLU297C, GLU297D, GLU308C, GLU308D, GLU329C, GLU533C, GLU585D, GLY195C, GLY198C, GLY217D, GLY219D, GLY287C, GLY287D, GLY291C, GLY291D, GLY294C, GLY295C, GLY295D, GLY300C, GLY302C, GLY302D, GLY515C, GLY547C, HIS141D, HIS221D, HIS552D, ILE146D, ILE180D, ILE183D, ILE196C, ILE206C, ILE220D, ILE267C, ILE276C, ILE328C, ILE328D, ILE373D, ILE388C, ILE574D, LEU139D, LEU182D, LEU188D, LEU192C, LEU211D, LEU222D, LEU268C, LEU290C, LEU307C, LEU307D, LEU319C, LEU319D, LEU376D, LEU465D, LEU500C, LEU528C, LYS176D, LYS205C, LYS269C, LYS279C, LYS283C, LYS283D, LYS304C, LYS304D, LYS306C, LYS306D, LYS333C, LYS384D, LYS390C, MET485D, PHE144D, PHE271C, PHE280C, PHE288C, PHE288D, PHE340C, PHE381D, PHE468D, PHE581D, PRO140D, PRO202C, PRO272C, PRO303C, PRO303D, PRO375D, PRO383D, PRO460D, SER147D, SER181D, SER191C, SER199C, SER215D, SER286C, SER286D, SER299C, SER299D, SER312C, SER312D, SER316C, SER316D, SER339C, SER352D, SER374D, SER377D, SER380D, SER392C, SER467D, SER488D, SER546C, SER570D, THR136D, THR138D, THR201C, THR216D, THR270C, THR293C, THR293D, THR314C, THR314D, THR320C, THR320D, THR323C, THR323D, THR349C, THR394C, THR529C, THR573D, THR575D, THR578D, TRP318C, TRP318D, TRP342D, TYR145D, TYR184D, TYR254D, TYR313D, TYR321C, TYR321D, TYR326D, TYR347D, TYR378D, TYR389C, TYR545C, TYR577D, VAL142D, VAL148D, VAL186D, VAL197C, VAL273C, VAL285C, VAL285D, VAL292C, VAL292D, VAL296C, VAL296D, VAL298C, VAL338C, VAL370D, VAL382D, VAL387C, VAL454D, VAL544C, VAL580D
• C-E: ARG282C, ARG372E, ASN371E, ASP369E, GLN315C, GLU284C, LYS283C, SER357E, THR320E, TRP318E, TYR313C, TYR347E
• D-E: ALA143E, ALA151E, ALA178E, ALA200D, ALA204D, ALA218E, ALA265D, ALA305D, ALA305E, ALA309D, ALA309E, ALA311D, ALA311E, ALA332D, ALA335D, ALA337D, ALA348D, ALA348E, ALA379E, ALA391D, ALA393D, ALA466E, ALA516D, ALA576E, ALA583E, ARG150E, ARG185E, ARG208E, ARG255D, ARG282D, ARG282E, ARG310D, ARG310E, ARG317D, ARG317E, ARG327D, ARG327E, ARG330D, ARG344E, ARG372E, ARG459E, ARG471E, ARG502D, ARG531D, ARG572E, ASN149E, ASN179E, ASN187E, ASN223E, ASN263D, ASN275D, ASN277D, ASN322E, ASN331D, ASN334D, ASN343D, ASN343E, ASN371E, ASN462E, ASN469E, ASN470E, ASN525D, ASN527D, ASN543D, ASN582E, ASP177E, ASP203D, ASP212E, ASP213E, ASP214E, ASP224E, ASP274D, ASP301D, ASP301E, ASP325E, ASP369E, ASP487E, ASP514D, ASP539E, ASP579E, CYS472E, CYS486E, CYS524D, GLN225E, GLN266D, GLN315D, GLN315E, GLN324E, GLN336D, GLN345D, GLN345E, GLN346D, GLN346E, GLN464E, GLN489E, GLN493E, GLN499D, GLN526D, GLN530D, GLU189E, GLU278D, GLU281D, GLU281E, GLU284D, GLU289D, GLU289E, GLU297D, GLU297E, GLU308D, GLU308E, GLU329D, GLU533D, GLU585E, GLY195D, GLY198D, GLY217E, GLY219E, GLY287D, GLY287E, GLY291D, GLY291E, GLY294D, GLY295D, GLY295E, GLY300D, GLY302D, GLY302E, GLY515D, GLY547D, HIS141E, HIS221E, HIS552E, ILE146E, ILE180E, ILE183E, ILE196D, ILE206D, ILE220E, ILE267D, ILE276D, ILE328D, ILE328E, ILE373E, ILE388D, ILE574E, LEU139E, LEU182E, LEU188E, LEU192D, LEU211E, LEU222E, LEU268D, LEU290D, LEU307D, LEU307E, LEU319D, LEU319E, LEU376E, LEU465E, LEU500D, LEU528D, LYS176E, LYS205D, LYS269D, LYS279D, LYS283D, LYS283E, LYS304D, LYS304E, LYS306D, LYS306E, LYS333D, LYS384E, LYS390D, MET485E, PHE144E, PHE271D, PHE280D, PHE280E, PHE288D, PHE288E, PHE340D, PHE381E, PHE468E, PHE581E, PRO140E, PRO202D, PRO272D, PRO303E, PRO375E, PRO383E, PRO460E, SER147E, SER181E, SER191D, SER199D, SER215E, SER286D, SER286E, SER299D, SER312D, SER312E, SER316D, SER316E, SER339D, SER352E, SER374E, SER377E, SER380E, SER392D, SER467E, SER488E, SER546D, THR136E, THR138E, THR201D, THR216E, THR270D, THR293D, THR293E, THR314D, THR314E, THR320D, THR320E, THR323D, THR323E, THR341D, THR349D, THR394D, THR529D, THR573E, THR575E, THR578E, TRP318D, TRP318E, TRP342E, TYR145E, TYR184E, TYR254E, TYR313D, TYR313E, TYR321D, TYR321E, TYR326E, TYR347D, TYR347E, TYR378E, TYR389D, TYR545D, TYR577E, VAL142E, VAL148E, VAL186E, VAL197D, VAL273D, VAL285D, VAL285E, VAL292D, VAL292E, VAL296D, VAL298D, VAL338D, VAL370E, VAL382E, VAL387D, VAL454E, VAL544D, VAL580E
• D-F: ARG282D, ARG372F, ASN355F, ASN371F, ASP369F, GLN315D, GLN346F, GLU284D, LYS283D, SER357F, THR320F, TRP318F, TYR313D, TYR347F
• D-G: PHE288D, SER357G
• E-F: ALA143F, ALA151F, ALA178F, ALA200E, ALA204E, ALA218F, ALA265E, ALA305E, ALA305F, ALA309E, ALA309F, ALA311E, ALA311F, ALA332E, ALA335E, ALA337E, ALA348E, ALA348F, ALA379F, ALA391E, ALA393E, ALA466F, ALA516E, ALA576F, ALA583F, ARG150F, ARG185F, ARG208F, ARG255E, ARG282E, ARG282F, ARG310E, ARG310F, ARG317E, ARG317F, ARG327E, ARG327F, ARG330E, ARG344F, ARG372F, ARG459F, ARG471F, ARG502E, ARG531E, ARG572F, ASN149F, ASN179F, ASN187F, ASN223F, ASN263E, ASN275E, ASN277E, ASN322F, ASN331E, ASN334E, ASN343E, ASN343F, ASN371F, ASN462F, ASN469F, ASN470F, ASN525E, ASN527E, ASN543E, ASN582F, ASP177F, ASP203E, ASP212F, ASP213F, ASP214F, ASP224F, ASP274E, ASP301E, ASP301F, ASP325F, ASP369F, ASP487F, ASP514E, ASP539F, ASP579F, CYS472F, CYS486F, CYS524E, GLN225F, GLN266E, GLN315E, GLN315F, GLN324F, GLN336E, GLN345E, GLN345F, GLN346E, GLN346F, GLN464F, GLN489F, GLN493F, GLN499E, GLN526E, GLN530E, GLU189F, GLU278E, GLU281E, GLU281F, GLU284E, GLU289E, GLU289F, GLU297E, GLU297F, GLU308E, GLU308F, GLU329E, GLU533E, GLU585F, GLY195E, GLY198E, GLY217F, GLY219F, GLY287E, GLY287F, GLY291E, GLY291F, GLY294E, GLY295E, GLY295F, GLY300E, GLY302E, GLY302F, GLY515E, GLY547E, HIS141F, HIS221F, HIS552F, ILE146F, ILE180F, ILE183F, ILE196E, ILE206E, ILE220F, ILE267E, ILE276E, ILE328E, ILE328F, ILE373F, ILE388E, ILE574F, LEU139F, LEU182F, LEU188F, LEU192E, LEU211F, LEU222F, LEU268E, LEU290E, LEU290F, LEU307E, LEU307F, LEU319E, LEU319F, LEU376F, LEU465F, LEU500E, LEU528E, LYS176F, LYS205E, LYS269E, LYS279E, LYS283E, LYS283F, LYS304E, LYS304F, LYS306E, LYS306F, LYS333E, LYS384F, LYS390E, MET485F, PHE144F, PHE271E, PHE280E, PHE280F, PHE288E, PHE288F, PHE340E, PHE381F, PHE468F, PHE581F, PRO140F, PRO202E, PRO272E, PRO303E, PRO303F, PRO375F, PRO383F, PRO460F, SER147F, SER181F, SER191E, SER199E, SER215F, SER286E, SER286F, SER299E, SER312E, SER312F, SER316E, SER316F, SER339E, SER352F, SER374F, SER377F, SER380F, SER392E, SER467F, SER488F, SER546E, THR136F, THR138F, THR201E, THR216F, THR270E, THR293E, THR293F, THR314E, THR314F, THR320E, THR320F, THR323E, THR323F, THR341E, THR349E, THR394E, THR529E, THR573F, THR575F, THR578F, TRP318E, TRP318F, TRP342F, TYR145F, TYR184F, TYR254F, TYR313E, TYR313F, TYR321E, TYR321F, TYR326F, TYR347E, TYR347F, TYR378F, TYR389E, TYR545E, TYR577F, VAL142F, VAL148F, VAL186F, VAL197E, VAL273E, VAL285E, VAL285F, VAL292E, VAL292F, VAL296E, VAL296F, VAL298E, VAL338E, VAL370F, VAL382F, VAL387E, VAL454F, VAL544E, VAL580F
• E-G: ARG282E, ARG372G, ASN355G, ASN371G, ASP369G, GLN315E, GLU284E, LYS283E, SER357G, THR320G, TRP318G, TYR313E, TYR347G
• F-G: ALA143G, ALA151G, ALA178G, ALA200F, ALA204F, ALA218G, ALA265F, ALA305G, ALA309G, ALA311G, ALA332F, ALA335F, ALA337F, ALA348F, ALA348G, ALA379G, ALA391F, ALA393F, ALA466G, ALA516F, ALA576G, ALA583G, ARG150G, ARG185G, ARG208G, ARG255F, ARG282F, ARG282G, ARG310F, ARG310G, ARG317F, ARG317G, ARG327F, ARG327G, ARG330F, ARG344G, ARG372G, ARG459G, ARG471G, ARG502F, ARG531F, ARG572G, ASN149G, ASN179G, ASN187G, ASN223G, ASN263F, ASN275F, ASN277F, ASN322G, ASN331F, ASN334F, ASN343F, ASN343G, ASN371G, ASN462G, ASN469G, ASN470G, ASN525F, ASN527F, ASN543F, ASN582G, ASP177G, ASP203F, ASP212G, ASP213G, ASP214G, ASP224G, ASP274F, ASP301F, ASP301G, ASP325G, ASP369G, ASP487G, ASP514F, ASP539G, ASP579G, CYS472G, CYS486G, CYS524F, GLN225G, GLN266F, GLN315F, GLN315G, GLN324G, GLN336F, GLN345F, GLN345G, GLN346F, GLN346G, GLN464G, GLN489G, GLN490G, GLN493G, GLN499F, GLN526F, GLN530F, GLU189G, GLU278F, GLU281F, GLU281G, GLU284F, GLU289F, GLU289G, GLU297F, GLU297G, GLU308F, GLU308G, GLU329F, GLU533F, GLU585G, GLY195F, GLY198F, GLY217G, GLY219G, GLY287F, GLY287G, GLY291F, GLY291G, GLY294F, GLY295F, GLY295G, GLY300F, GLY302F, GLY302G, GLY515F, GLY547F, HIS141G, HIS221G, HIS552G, ILE146G, ILE180G, ILE183G, ILE196F, ILE206F, ILE220G, ILE267F, ILE276F, ILE328F, ILE328G, ILE373G, ILE388F, ILE574G, LEU139G, LEU182G, LEU188G, LEU192F, LEU211G, LEU222G, LEU268F, LEU290F, LEU307F, LEU307G, LEU319F, LEU319G, LEU376G, LEU465G, LEU500F, LEU528F, LYS176G, LYS205F, LYS269F, LYS279F, LYS283F, LYS283G, LYS304F, LYS304G, LYS306F, LYS306G, LYS333F, LYS384G, LYS390F, MET485G, PHE144G, PHE271F, PHE280F, PHE280G, PHE288F, PHE288G, PHE340F, PHE381G, PHE468G, PHE581G, PRO140G, PRO202F, PRO272F, PRO303F, PRO303G, PRO375G, PRO383G, PRO460G, SER147G, SER181G, SER191F, SER199F, SER215G, SER286F, SER286G, SER299F, SER299G, SER312F, SER312G, SER316F, SER316G, SER339F, SER352G, SER374G, SER377G, SER380G, SER392F, SER467G, SER488G, SER546F, THR136G, THR138G, THR201F, THR216G, THR270F, THR293F, THR293G, THR314F, THR314G, THR320F, THR320G, THR323F, THR323G, THR349F, THR394F, THR529F, THR573G, THR575G, THR578G, TRP318F, TRP318G, TRP342G, TYR145G, TYR184G, TYR254G, TYR313F, TYR313G, TYR321F, TYR321G, TYR326G, TYR347F, TYR347G, TYR378G, TYR389F, TYR545F, TYR577G, VAL142G, VAL148G, VAL186G, VAL197F, VAL273F, VAL285F, VAL285G, VAL292F, VAL292G, VAL296F, VAL296G, VAL298F, VAL338F, VAL370G, VAL382G, VAL387F, VAL454G, VAL544F, VAL580G
• H-I: ALA143I, ALA151I, ALA178I, ALA200H, ALA204H, ALA218I, ALA265H, ALA305I, ALA309I, ALA311I, ALA332H, ALA335H, ALA337H, ALA348H, ALA348I, ALA379I, ALA391H, ALA393H, ALA466I, ALA516H, ALA576I, ALA583I, ARG150I, ARG185I, ARG208I, ARG255H, ARG282H, ARG310H, ARG310I, ARG317I, ARG327H, ARG327I, ARG330H, ARG344I, ARG372I, ARG459I, ARG471I, ARG502H, ARG531H, ARG572I, ASN149I, ASN179I, ASN187I, ASN223I, ASN263H, ASN275H, ASN277H, ASN322I, ASN331H, ASN334H, ASN343H, ASN343I, ASN371I, ASN462I, ASN469I, ASN470I, ASN525H, ASN527H, ASN543H, ASN582I, ASP177I, ASP203H, ASP212I, ASP213I, ASP214I, ASP224I, ASP274H, ASP301H, ASP301I, ASP325I, ASP369I, ASP487I, ASP514H, ASP539I, ASP579I, CYS472I, CYS486I, CYS524H, GLN225I, GLN266H, GLN315I, GLN324I, GLN336H, GLN345H, GLN345I, GLN346H, GLN346I, GLN464I, GLN489I, GLN490I, GLN493I, GLN499H, GLN526H, GLN530H, GLU189I, GLU278H, GLU281H, GLU281I, GLU284H, GLU289H, GLU289I, GLU297H, GLU297I, GLU308H, GLU308I, GLU329H, GLU533H, GLU585I, GLY195H, GLY198H, GLY217I, GLY219I, GLY287H, GLY287I, GLY291H, GLY291I, GLY294H, GLY295H, GLY295I, GLY300H, GLY302H, GLY302I, GLY515H, GLY547H, HIS141I, HIS221I, HIS552I, ILE146I, ILE180I, ILE183I, ILE196H, ILE206H, ILE220I, ILE267H, ILE276H, ILE328H, ILE328I, ILE373I, ILE388H, ILE574I, LEU139I, LEU182I, LEU188I, LEU192H, LEU211I, LEU222I, LEU268H, LEU290H, LEU307I, LEU319H, LEU319I, LEU376I, LEU465I, LEU500H, LEU528H, LYS176I, LYS205H, LYS269H, LYS279H, LYS283H, LYS283I, LYS304H, LYS304I, LYS306H, LYS306I, LYS333H, LYS384I, LYS390H, MET485I, PHE144I, PHE271H, PHE280H, PHE288H, PHE288I, PHE340H, PHE381I, PHE468I, PHE581I, PRO140I, PRO202H, PRO272H, PRO303I, PRO375I, PRO383I, PRO460I, SER147I, SER181I, SER191H, SER199H, SER215I, SER286H, SER299H, SER299I, SER312H, SER312I, SER316I, SER339H, SER352I, SER374I, SER377I, SER380I, SER392H, SER467I, SER488I, SER546H, SER570I, THR136I, THR138I, THR201H, THR216I, THR270H, THR293H, THR293I, THR314H, THR314I, THR320H, THR320I, THR323H, THR323I, THR349H, THR394H, THR529H, THR573I, THR575I, THR578I, TRP318H, TRP318I, TRP342I, TYR145I, TYR184I, TYR254I, TYR313I, TYR321H, TYR321I, TYR326I, TYR347H, TYR347I, TYR378I, TYR389H, TYR545H, TYR577I, VAL142I, VAL148I, VAL186I, VAL197H, VAL273H, VAL285H, VAL285I, VAL292H, VAL292I, VAL296H, VAL296I, VAL298H, VAL338H, VAL370I, VAL382I, VAL387H, VAL454I, VAL544H, VAL580I
• H-J: ARG282H, ARG372J, ASN371J, ASP369J, GLN315H, GLU284H, LYS283H, SER357J, THR320J, TRP318J, TYR313H, TYR347J
• H-N: ALA305H, ALA309H, ALA311H, ALA332N, ALA379H, ARG282N, ARG310H, ARG310N, ARG317H, ARG330N, ARG531N, ARG572H, ASN149H, ASN277N, ASN331N, ASN469H, ASP212H, ASP213H, ASP214H, ASP224H, ASP274N, ASP325H, GLN266N, GLN315H, GLN464H, GLU278N, GLU281H, GLU281N, GLU284N, GLU289H, GLU289N, GLU297H, GLU297N, GLU308H, GLU308N, GLU329N, GLY198N, GLY217H, GLY294N, HIS141H, HIS221H, LEU268N, LEU290N, LEU307H, LEU319H, LEU528N, LYS269N, LYS283H, LYS283N, LYS384H, PHE280N, PHE288N, SER286N, SER467H, THR216H, THR323H, THR529N, TYR313H, TYR321H, TYR326H, TYR545N, VAL292N, VAL296N, VAL298N, VAL382H, VAL544N
• I-J: ALA143J, ALA151J, ALA178J, ALA200I, ALA204I, ALA218J, ALA265I, ALA305I, ALA305J, ALA309I, ALA309J, ALA311I, ALA311J, ALA332I, ALA335I, ALA337I, ALA348I, ALA348J, ALA379J, ALA391I, ALA393I, ALA466J, ALA516I, ALA576J, ALA583J, ARG150J, ARG185J, ARG208J, ARG255I, ARG282I, ARG282J, ARG310I, ARG310J, ARG317I, ARG317J, ARG327I, ARG327J, ARG330I, ARG344J, ARG372J, ARG459J, ARG471J, ARG502I, ARG531I, ARG572J, ASN149J, ASN179J, ASN187J, ASN223J, ASN263I, ASN275I, ASN277I, ASN322J, ASN331I, ASN334I, ASN343I, ASN343J, ASN371J, ASN462J, ASN469J, ASN470J, ASN525I, ASN527I, ASN543I, ASN582J, ASP177J, ASP203I, ASP212J, ASP213J, ASP214J, ASP224J, ASP274I, ASP301I, ASP301J, ASP325J, ASP369J, ASP487J, ASP514I, ASP539J, ASP579J, CYS472J, CYS486J, CYS524I, GLN225J, GLN266I, GLN315I, GLN315J, GLN324J, GLN336I, GLN345I, GLN345J, GLN346I, GLN346J, GLN464J, GLN489J, GLN490J, GLN493J, GLN499I, GLN526I, GLN530I, GLU189J, GLU278I, GLU281I, GLU281J, GLU284I, GLU284J, GLU289I, GLU289J, GLU297I, GLU297J, GLU308I, GLU308J, GLU329I, GLU533I, GLU585J, GLY195I, GLY198I, GLY217J, GLY219J, GLY287I, GLY287J, GLY291I, GLY291J, GLY294I, GLY295I, GLY295J, GLY300I, GLY302I, GLY302J, GLY515I, GLY547I, HIS141J, HIS221J, HIS452J, HIS552J, ILE146J, ILE180J, ILE183J, ILE196I, ILE206I, ILE220J, ILE267I, ILE276I, ILE328I, ILE328J, ILE373J, ILE388I, ILE574J, LEU139J, LEU182J, LEU188J, LEU192I, LEU211J, LEU222J, LEU268I, LEU290I, LEU290J, LEU307I, LEU307J, LEU319I, LEU319J, LEU376J, LEU465J, LEU500I, LEU528I, LYS176J, LYS205I, LYS269I, LYS279I, LYS283I, LYS283J, LYS304I, LYS304J, LYS306I, LYS306J, LYS333I, LYS384J, LYS390I, MET485J, PHE144J, PHE271I, PHE280I, PHE280J, PHE288I, PHE288J, PHE340I, PHE381J, PHE468J, PHE581J, PRO140J, PRO202I, PRO272I, PRO303I, PRO303J, PRO375J, PRO383J, PRO460J, SER147J, SER181J, SER191I, SER199I, SER215J, SER286I, SER286J, SER299I, SER312I, SER312J, SER316I, SER316J, SER339I, SER352J, SER374J, SER377J, SER380J, SER392I, SER467J, SER488J, SER546I, THR136J, THR138J, THR201I, THR216J, THR270I, THR293I, THR293J, THR314I, THR314J, THR320I, THR320J, THR323I, THR323J, THR341I, THR349I, THR394I, THR529I, THR573J, THR575J, THR578J, TRP318I, TRP318J, TRP342J, TYR145J, TYR184J, TYR254J, TYR313I, TYR313J, TYR321I, TYR321J, TYR326J, TYR347J, TYR378J, TYR389I, TYR545I, TYR577J, VAL142J, VAL148J, VAL186J, VAL197I, VAL273I, VAL285I, VAL285J, VAL292I, VAL292J, VAL296I, VAL296J, VAL298I, VAL338I, VAL370J, VAL382J, VAL387I, VAL454J, VAL544I, VAL580J
• I-K: ARG282I, ARG372K, ASN355K, ASN371K, ASP369K, GLN315I, GLN346K, GLU284I, GLU289I, LYS283I, SER357K, THR314K, THR320K, TRP318K, TYR313I, TYR347K
• I-L: PHE288I, SER357L
• J-K: ALA143K, ALA151K, ALA178K, ALA200J, ALA204J, ALA218K, ALA265J, ALA305J, ALA305K, ALA309J, ALA309K, ALA311J, ALA311K, ALA332J, ALA335J, ALA337J, ALA348J, ALA348K, ALA379K, ALA391J, ALA393J, ALA466K, ALA516J, ALA576K, ALA583K, ARG150K, ARG185K, ARG208K, ARG255J, ARG282J, ARG282K, ARG310J, ARG310K, ARG317J, ARG317K, ARG327J, ARG327K, ARG330J, ARG344K, ARG372K, ARG459K, ARG471K, ARG502J, ARG531J, ARG572K, ASN149K, ASN179K, ASN187K, ASN223K, ASN263J, ASN275J, ASN277J, ASN322K, ASN331J, ASN334J, ASN343J, ASN343K, ASN371K, ASN462K, ASN469K, ASN470K, ASN525J, ASN527J, ASN543J, ASN582K, ASP177K, ASP203J, ASP212K, ASP213K, ASP214K, ASP224K, ASP274J, ASP301J, ASP301K, ASP325K, ASP369K, ASP487K, ASP514J, ASP539K, ASP579K, CYS472K, CYS486K, CYS524J, GLN225K, GLN266J, GLN315J, GLN315K, GLN324K, GLN336J, GLN345J, GLN345K, GLN346J, GLN346K, GLN464K, GLN489K, GLN490K, GLN493K, GLN499J, GLN526J, GLN530J, GLU189K, GLU278J, GLU281J, GLU281K, GLU284J, GLU289J, GLU289K, GLU297J, GLU297K, GLU308J, GLU308K, GLU329J, GLU533J, GLY195J, GLY198J, GLY217K, GLY219K, GLY287J, GLY287K, GLY291J, GLY291K, GLY294J, GLY295J, GLY295K, GLY300J, GLY302J, GLY302K, GLY515J, GLY547J, HIS141K, HIS221K, HIS552K, ILE146K, ILE180K, ILE183K, ILE196J, ILE206J, ILE220K, ILE267J, ILE276J, ILE328J, ILE328K, ILE373K, ILE388J, ILE574K, LEU139K, LEU182K, LEU188K, LEU192J, LEU211K, LEU222K, LEU268J, LEU290J, LEU290K, LEU307J, LEU307K, LEU319J, LEU319K, LEU376K, LEU465K, LEU500J, LEU528J, LYS176K, LYS205J, LYS269J, LYS279J, LYS283J, LYS283K, LYS304J, LYS304K, LYS306J, LYS306K, LYS333J, LYS384K, LYS390J, MET485K, PHE144K, PHE271J, PHE280J, PHE280K, PHE288J, PHE288K, PHE340J, PHE381K, PHE468K, PHE581K, PRO140K, PRO202J, PRO272J, PRO303J, PRO303K, PRO375K, PRO383K, PRO460K, SER147K, SER181K, SER191J, SER199J, SER215K, SER286J, SER286K, SER299J, SER312J, SER312K, SER316J, SER316K, SER339J, SER352K, SER374K, SER377K, SER380K, SER392J, SER467K, SER488K, SER546J, THR136K, THR138K, THR201J, THR216K, THR270J, THR293J, THR293K, THR314J, THR314K, THR320J, THR320K, THR323J, THR323K, THR341J, THR349J, THR394J, THR529J, THR573K, THR575K, THR578K, TRP318J, TRP318K, TRP342K, TYR145K, TYR184K, TYR254K, TYR313J, TYR313K, TYR321J, TYR321K, TYR326K, TYR347J, TYR347K, TYR378K, TYR389J, TYR545J, TYR577K, VAL142K, VAL148K, VAL186K, VAL197J, VAL273J, VAL285J, VAL285K, VAL292J, VAL292K, VAL296J, VAL296K, VAL298J, VAL338J, VAL370K, VAL382K, VAL387J, VAL454K, VAL544J, VAL580K
• J-L: ARG282J, ARG372L, ASN355L, ASN371L, ASP369L, GLN315J, GLU284J, LYS283J, SER357L, TRP318L, TYR313J, TYR347L
• K-L: ALA143L, ALA151L, ALA178L, ALA200K, ALA204K, ALA218L, ALA265K, ALA305L, ALA309L, ALA311L, ALA332K, ALA335K, ALA337K, ALA348K, ALA348L, ALA379L, ALA391K, ALA393K, ARG150L, ARG185L, ARG208L, ARG255K, ARG282K, ARG310K, ARG310L, ARG317L, ARG327K, ARG327L, ARG330K, ARG344L, ARG372L, ARG531K, ARG572L, ASN149L, ASN179L, ASN187L, ASN223L, ASN263K, ASN275K, ASN277K, ASN322L, ASN331K, ASN334K, ASN343K, ASN343L, ASN371L, ASN469L, ASP177L, ASP203K, ASP212L, ASP213L, ASP214L, ASP224L, ASP274K, ASP301K, ASP301L, ASP325L, ASP369L, GLN225L, GLN266K, GLN315L, GLN324L, GLN336K, GLN345K, GLN345L, GLN346K, GLN346L, GLN464L, GLN499K, GLU189L, GLU278K, GLU281K, GLU281L, GLU284K, GLU289K, GLU289L, GLU297K, GLU297L, GLU308K, GLU308L, GLU329K, GLY195K, GLY198K, GLY217L, GLY219L, GLY287K, GLY287L, GLY291K, GLY291L, GLY294K, GLY295K, GLY295L, GLY300K, GLY302K, GLY302L, HIS141L, HIS221L, ILE146L, ILE180L, ILE183L, ILE196K, ILE206K, ILE220L, ILE267K, ILE276K, ILE328K, ILE328L, ILE373L, ILE388K, LEU139L, LEU182L, LEU188L, LEU192K, LEU211L, LEU222L, LEU268K, LEU290K, LEU307K, LEU307L, LEU319K, LEU319L, LEU376L, LEU528K, LYS176L, LYS205K, LYS269K, LYS279K, LYS283K, LYS283L, LYS304K, LYS304L, LYS306K, LYS306L, LYS333K, LYS384L, LYS390K, PHE144L, PHE271K, PHE280K, PHE288K, PHE288L, PHE340K, PHE381L, PRO140L, PRO202K, PRO272K, PRO303K, PRO303L, PRO375L, PRO383L, SER147L, SER181L, SER191K, SER199K, SER215L, SER286K, SER286L, SER299K, SER299L, SER312K, SER312L, SER316K, SER316L, SER339K, SER352L, SER374L, SER377L, SER380L, SER392K, THR136L, THR138L, THR201K, THR216L, THR270K, THR293K, THR293L, THR314K, THR314L, THR320K, THR320L, THR323K, THR323L, THR341K, THR349K, THR529K, TRP318K, TRP318L, TRP342L, TYR145L, TYR184L, TYR313K, TYR313L, TYR321K, TYR321L, TYR326L, TYR347K, TYR347L, TYR378L, TYR389K, TYR545K, VAL142L, VAL148L, VAL186L, VAL197K, VAL273K, VAL285K, VAL285L, VAL292K, VAL292L, VAL296K, VAL296L, VAL298K, VAL338K, VAL370L, VAL382L, VAL387K, VAL544K
• L-M: ALA305M, ALA309M, ALA311M, ALA332L, ALA379M, ARG282L, ARG310L, ARG310M, ARG317M, ARG330L, ARG531L, ARG572M, ASN149M, ASN277L, ASN469M, ASP177M, ASP212M, ASP213M, ASP214M, ASP224M, ASP274L, ASP325M, GLN266L, GLN315M, GLN464M, GLN526L, GLU278L, GLU281L, GLU281M, GLU284L, GLU289L, GLU289M, GLU297L, GLU297M, GLU308L, GLU308M, GLY198L, GLY217M, GLY294L, HIS141M, HIS221M, LEU268L, LEU290L, LEU307M, LEU319M, LEU528L, LYS269L, LYS283L, LYS283M, LYS333L, LYS384M, PHE280L, PHE288L, SER147M, SER286L, SER380M, THR216M, THR320M, THR323M, THR529L, TYR313M, TYR321M, TYR326M, TYR545L, VAL292L, VAL296L, VAL298L, VAL382M
• M-N: ALA305N, ALA309N, ALA311N, ALA332M, ALA335M, ALA379N, ARG282M, ARG310M, ARG310N, ARG317N, ARG330M, ASN149N, ASN277M, ASN331M, ASN469N, ASP212N, ASP213N, ASP214N, ASP224N, ASP274M, ASP325N, GLN266M, GLN315N, GLU278M, GLU281M, GLU281N, GLU284M, GLU289M, GLU289N, GLU297M, GLU297N, GLU308M, GLU308N, GLY198M, GLY217N, GLY294M, HIS141N, HIS221N, LEU268M, LEU290M, LEU307N, LEU319N, LEU528M, LYS269M, LYS283M, LYS283N, LYS384N, PHE280M, PHE288M, SER147N, SER181N, SER286M, SER380N, THR216N, THR320N, THR323N, THR529M, TYR313N, TYR321N, TYR326N, VAL292M, VAL296M, VAL298M, VAL382N