3NP5

crystal structure of an abridged form of the mature ectodomain of the human receptor-type protein tyrosine phosphatase ica512/ia-2 at ph 4.5

• Total interactions analyzed: 6
• Total true interactions: 6
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 48
  • Norm. En. per Res.: -4.0469
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-50.9469	-1.1598	-116.171	-168.2776	47	6	2	3833	0	3	6
A-C	-13.0732	23.983	-83.1754	-72.2655	46	1	2	3369	0	10	9
A-D	0.0	3.8267	-18.4974	-14.6707	28	1	0	939	0	10	10
B-C	0.0	8.3187	-41.5471	-33.2284	40	5	0	1696	0	13	14
B-D	-9.7298	11.8971	-77.6038	-75.4365	47	4	2	3287	0	7	8
C-D	-80.1234	-1.7468	-112.381	-194.2512	48	13	2	4378	0	6	7

Interface residues

• A-B: ALA513B, ALA528A, ALA528B, ALA534A, ARG557B, ASP529A, GLN532A, GLN532B, GLN533A, GLN551A, GLN551B, GLN556A, GLN556B, GLU470A, GLU470B, GLU558B, GLY472A, GLY472B, GLY535A, GLY553A, GLY553B, GLY555A, GLY555B, HIS520A, ILE474B, ILE549A, LEU527A, LEU527B, LEU536A, LEU550A, LYS538A, PHE516A, SER526A, THR515B, THR531A, THR531B, THR552A, THR552B, TYR471A, TYR471B, TYR473A, TYR473B, VAL475A, VAL475B, VAL530A, VAL554A, VAL554B
• A-C: ALA494A, ALA494C, ALA528A, ALA528C, ASN521A, ASN521C, ASN524A, ASN524C, ASP529A, ASP529C, GLN523A, GLN523C, GLN532A, GLN532C, GLN533A, GLN533C, GLU495A, GLU495C, GLU522A, GLU540A, GLU540C, GLY535A, GLY535C, HIS496A, HIS496C, HIS498A, HIS498C, LEU493C, LEU525A, LEU525C, LEU536A, LEU536C, LYS538A, LYS538C, MET499A, MET499C, SER526A, SER526C, SER539A, SER539C, VAL497A, VAL497C, VAL530A, VAL530C, VAL537A, VAL537C
• A-D: ALA528D, ARG517A, ARG517D, ARG519A, ARG519D, ASN521A, ASN521D, ASN524A, ASN524D, GLN523A, GLN523D, GLN556D, GLU470A, GLU470D, GLU522A, GLU522D, GLU558D, GLY555D, HIS520A, HIS520D, ILE518D, LEU525D, LEU527A, LEU527D, SER526A, SER526D, TYR471D, VAL554D
• B-C: ALA528B, ALA528C, ARG517B, ARG517C, ARG519B, ARG519C, ARG557B, ARG557C, ASN521B, ASN521C, ASN524B, ASN524C, ASP529B, ASP529C, GLN523B, GLN523C, GLN556B, GLN556C, GLU470B, GLU470C, GLU522B, GLU522C, GLU558B, GLY555B, GLY555C, HIS520B, HIS520C, ILE505B, ILE505C, ILE518B, ILE518C, LEU525B, LEU525C, LEU527B, LEU527C, SER526B, SER526C, TYR471B, TYR471C, VAL554C
• B-D: ALA494B, ALA494D, ALA528B, ALA528D, ALA534D, ASN521D, ASN524B, ASN524D, ASP529B, ASP529D, GLN523B, GLN523D, GLN532B, GLN532D, GLN533B, GLN533D, GLU495B, GLU495D, GLU540B, GLU540D, GLY535B, GLY535D, GLY553B, HIS496B, HIS496D, HIS498B, HIS498D, LEU493D, LEU525B, LEU525D, LEU536B, LEU536D, LYS538B, LYS538D, MET499B, MET499D, SER526B, SER526D, SER539B, SER539D, THR552B, VAL497B, VAL497D, VAL530B, VAL530D, VAL537B, VAL537D
• C-D: ALA528C, ALA528D, ALA534C, ALA534D, ARG557C, ARG557D, GLN532C, GLN532D, GLN548C, GLN551C, GLN551D, GLN556C, GLN556D, GLU470C, GLU470D, GLU542C, GLU558D, GLY472C, GLY472D, GLY535C, GLY535D, GLY553C, GLY553D, GLY555C, GLY555D, ILE474C, ILE474D, ILE549C, ILE549D, LEU536C, LEU536D, LEU550C, LEU550D, LYS538C, LYS538D, SER526C, THR531C, THR531D, THR552C, THR552D, TYR471C, TYR471D, TYR473C, TYR473D, VAL475C, VAL475D, VAL554C, VAL554D