3NNK

biochemical and structural characterization of a ureidoglycine aminotransferase in the klebsiella pneumoniae uric acid catabolic pathway

• Total interactions analyzed: 120
• Total true interactions: 31
• Strongest Interaction:
  • Chains: O-P
  • Int. Res.: 315
  • Norm. En. per Res.: -3.9385
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-115.9371	-108.6723	-981.987	-1206.5964	314	59	13	41073	14	87	91
A-C	-20.1387	-36.9198	-343.383	-400.4415	141	20	0	12721	2	31	23
A-D	0.0	0.0	-38.9249	-38.9249	40	2	0	1793	0	6	14
A-F	0.0	0.0	-0.2233	-0.2233	5	0	0	49	0	1	0
A-S	0.0	1.918	-27.2996	-25.3817	21	3	0	1629	0	24	26
B-C	0.0	0.0	-42.0062	-42.0062	43	1	0	2041	0	6	15
B-D	-26.4386	-45.6239	-350.02	-422.0825	141	23	0	13312	2	31	23
B-H	0.0	-17.5514	-3.1355	-20.6869	16	0	0	194	0	8	12
C-D	-127.6124	-116.3478	-974.755	-1218.7152	312	55	13	40323	16	84	92
C-F	-6.952	0.0	-4.6104	-11.5623	7	1	0	158	0	2	1
E-F	-132.7655	-100.458	-981.065	-1214.2885	314	55	14	40435	13	86	91
E-G	-18.5754	-38.1934	-342.72	-399.4888	142	22	0	12918	2	32	24
E-H	-2.0952	0.0	-40.3809	-42.4761	41	1	0	1836	0	6	14
F-G	0.0	0.0	-45.7609	-45.7609	45	3	0	2127	0	6	15
F-H	-22.5127	-44.6161	-358.541	-425.6698	141	22	0	13423	2	32	24
G-H	-109.5312	-158.5201	-955.254	-1223.3053	312	56	14	40572	17	85	89
J-K	-121.7945	-104.1006	-978.877	-1204.7721	309	51	14	40746	13	86	91
J-L	-26.2798	-47.8186	-358.028	-432.1265	143	20	0	13339	2	31	25
J-M	0.0	0.0	-39.6633	-39.6633	41	1	0	1868	0	6	12
J-R	0.0	-4.5357	-0.3246	-4.8603	2	0	0	36	0	8	3
J-S	-6.7644	-8.7892	-33.0494	-48.603	32	8	0	1828	1	8	11
K-L	0.0	0.0	-45.1846	-45.1846	47	2	0	2102	0	6	15
K-M	-29.0464	-46.1968	-361.943	-437.1863	143	25	0	13443	2	33	25
L-M	-106.7929	-96.2167	-976.93	-1179.9396	311	54	13	39991	10	83	90
L-S	0.0	0.0	-32.7877	-32.7877	23	5	0	1377	0	1	0
O-P	-113.9471	-145.9711	-980.709	-1240.6272	315	53	15	40646	12	87	93
O-R	-22.3581	-50.0595	-353.941	-426.3586	143	19	0	13214	2	32	25
O-S	-2.1002	0.0	-40.8	-42.9002	41	1	0	1904	0	6	14
P-R	0.0	0.0	-41.4983	-41.4983	43	3	0	1971	0	6	13
P-S	-23.4228	-44.9068	-244.372	-312.7017	113	19	0	10023	2	25	22
R-S	-115.0335	-106.0175	-945.637	-1166.688	309	56	13	40573	15	86	89

Interface residues

• A-B: ALA107A, ALA107B, ALA112A, ALA112B, ALA24A, ALA24B, ALA269A, ALA269B, ALA272A, ALA272B, ALA280A, ALA280B, ALA31A, ALA31B, ALA43A, ALA43B, ALA53A, ALA53B, ALA75A, ALA75B, ALA79A, ALA79B, ARG108A, ARG108B, ARG109A, ARG109B, ARG111A, ARG111B, ARG14A, ARG14B, ARG224A, ARG224B, ARG232A, ARG232B, ARG262A, ARG262B, ARG277A, ARG277B, ARG27A, ARG27B, ARG281A, ARG281B, ARG30A, ARG30B, ARG339A, ARG339B, ARG363A, ARG363B, ARG372A, ARG56A, ARG56B, ARG74A, ARG74B, ARG98A, ARG98B, ASN10A, ASN10B, ASN23A, ASN23B, ASN247A, ASN247B, ASN264A, ASN264B, ASN370A, ASN370B, ASN49A, ASN49B, ASP238A, ASP238B, ASP250A, ASP250B, ASP25A, ASP25B, ASP2A, ASP2B, ASP41A, ASP41B, ASP70A, ASP70B, CYS104A, CYS104B, CYS110A, CYS110B, CYS226A, CYS226B, GLN199A, GLN199B, GLN285A, GLN285B, GLN35A, GLN35B, GLN39A, GLN39B, GLN5A, GLN5B, GLN8A, GLN8B, GLU105A, GLU105B, GLU228A, GLU228B, GLU229A, GLU229B, GLU242A, GLU242B, GLU261B, GLU268A, GLU268B, GLU278A, GLU278B, GLU286A, GLU286B, GLU344A, GLU344B, GLU349A, GLU349B, GLU50A, GLU50B, GLU78A, GLU78B, GLY100A, GLY100B, GLY18A, GLY18B, GLY203A, GLY203B, GLY204A, GLY204B, GLY207A, GLY207B, GLY20A, GLY20B, GLY230A, GLY230B, GLY252A, GLY252B, GLY275A, GLY275B, GLY287A, GLY287B, GLY347A, GLY347B, GLY355A, GLY355B, GLY38A, GLY38B, GLY57A, GLY57B, GLY71A, GLY71B, GLY76A, GLY76B, GLY97A, GLY97B, HIS101A, HIS101B, HIS265A, HIS265B, HIS266A, HIS266B, HIS46A, HIS46B, ILE106A, ILE106B, ILE22A, ILE22B, ILE231A, ILE231B, ILE244A, ILE244B, ILE283A, ILE283B, ILE37A, ILE37B, ILE3A, ILE3B, ILE77A, ILE77B, LEU102A, LEU102B, LEU103A, LEU103B, LEU15A, LEU15B, LEU16A, LEU16B, LEU251A, LEU251B, LEU263A, LEU263B, LEU273A, LEU273B, LEU282A, LEU282B, LEU284A, LEU284B, LEU29A, LEU29B, LEU343A, LEU343B, LEU36A, LEU36B, LEU54A, LEU54B, LEU81B, LEU9A, LEU9B, LYS225A, LYS225B, LYS340A, LYS340B, MET198A, MET198B, MET1A, MET243A, MET243B, MET253A, MET253B, MET32A, MET32B, MET44A, MET44B, MET52A, MET52B, PHE249A, PHE249B, PHE274A, PHE274B, PHE354A, PHE354B, PHE6A, PHE6B, PHE99A, PHE99B, PRO11A, PRO11B, PRO12A, PRO12B, PRO19A, PRO19B, PRO205A, PRO205B, PRO21A, PRO21B, PRO26A, PRO26B, PRO356A, PRO356B, PRO42A, PRO42B, PRO87A, PRO87B, SER13A, SER13B, SER206A, SER206B, SER209A, SER246A, SER246B, SER33A, SER33B, SER34A, SER34B, SER73A, SER73B, SER7A, SER7B, SER83B, THR116B, THR208A, THR208B, THR233A, THR233B, THR267A, THR267B, THR270A, THR270B, THR271A, THR271B, THR352A, THR352B, THR4A, THR4B, THR72A, THR72B, TRP121A, TRP121B, TYR245A, TYR245B, TYR248A, TYR248B, TYR257A, TYR257B, TYR369A, TYR40A, TYR40B, TYR47A, TYR47B, TYR55A, TYR55B, VAL114B, VAL227A, VAL227B, VAL28A, VAL28B, VAL51A, VAL51B, VAL58A, VAL58B, VAL69A, VAL69B, VAL82A, VAL82B, VAL95B
• A-C: ALA31A, ALA338A, ALA382A, ALA382C, ALA385A, ALA385C, ALA398A, ALA398C, ALA399A, ALA399C, ALA402A, ALA402C, ALA403A, ALA403C, ARG14A, ARG14C, ARG277A, ARG27A, ARG27C, ARG281A, ARG281C, ARG30A, ARG30C, ARG372A, ARG372C, ARG408A, ARG408C, ASN10A, ASN10C, ASN370A, ASN370C, ASN388A, ASN388C, ASP25A, ASP25C, ASP345A, ASP345C, ASP374A, ASP374C, ASP405A, ASP405C, CYS375A, CYS375C, GLN285A, GLN285C, GLN35A, GLN35C, GLN396A, GLN396C, GLN401A, GLN401C, GLN8A, GLN8C, GLU278A, GLU278C, GLU344A, GLU344C, GLU384A, GLU384C, GLY347A, GLY347C, GLY397A, GLY397C, ILE348A, ILE348C, LEU15A, LEU15C, LEU282A, LEU282C, LEU29A, LEU29C, LEU341A, LEU341C, LEU343A, LEU343C, LEU380A, LEU380C, LEU383A, LEU383C, LEU387A, LEU387C, LEU390A, LEU390C, LEU9A, LEU9C, LYS340C, LYS373A, LYS373C, LYS391A, LYS391C, MET309A, MET309C, MET342A, MET342C, MET377A, MET377C, MET400A, MET400C, PHE346A, PHE346C, PHE392A, PHE392C, PRO11A, PRO11C, PRO12A, PRO12C, PRO26A, PRO26C, PRO393A, PRO393C, SER13A, SER13C, SER33A, SER33C, SER381A, SER381C, SER7A, SER7C, THR378A, THR378C, THR379A, THR379C, THR394A, THR394C, THR395A, THR395C, THR4A, TRP404A, TRP404C, TYR369A, TYR369C, TYR389A, TYR389C, TYR407A, TYR407C, VAL28A, VAL28C, VAL376A, VAL376C, VAL386A, VAL386C
• A-D: ALA31A, ALA31D, ARG27A, ARG27D, ARG281A, ARG281D, ARG30A, ARG30D, ASP2D, GLN285A, GLN285D, GLN35A, GLN35D, GLN5A, GLN5D, GLN8A, GLN8D, ILE3A, LEU29A, LEU29D, LEU9A, LEU9D, MET32A, MET32D, PHE274A, PHE274D, PRO26A, PRO26D, SER33A, SER33D, SER34A, SER34D, SER7A, SER7D, THR4A, THR4D, TYR369A, TYR369D, TYR47A, TYR47D
• A-F: ASN334A, GLN337A, LYS340A, PRO393F, THR395F
• A-S: ALA133S, ARG136A, ARG136S, ARG138A, ARG138S, ARG166A, ASP132A, ASP132S, ASP168A, GLU131A, GLU131S, HIS115S, ILE137A, ILE137S, LYS135A, LYS135S, LYS90A, LYS90S, TYR167A, VAL134A, VAL134S
• B-C: ALA24B, ALA31B, ALA31C, ARG27B, ARG27C, ARG281B, ARG281C, ARG30B, ARG30C, ASN23B, GLN285B, GLN285C, GLN35B, GLN35C, GLN5B, GLN5C, GLN8B, GLN8C, LEU29B, LEU29C, LEU36C, LEU9B, LEU9C, MET32B, MET32C, PHE274B, PHE274C, PRO26B, PRO26C, SER13B, SER13C, SER33B, SER33C, SER34B, SER34C, SER7B, SER7C, THR4B, THR4C, TYR369B, TYR369C, TYR47B, TYR47C
• B-D: ALA31B, ALA31D, ALA338D, ALA382B, ALA382D, ALA385B, ALA385D, ALA398B, ALA398D, ALA399B, ALA399D, ALA402B, ALA402D, ALA403B, ALA403D, ARG14B, ARG14D, ARG277B, ARG277D, ARG27B, ARG27D, ARG281B, ARG281D, ARG30B, ARG30D, ARG372B, ARG372D, ARG408B, ARG408D, ASN10B, ASN10D, ASN370B, ASN370D, ASN388B, ASN388D, ASP25B, ASP25D, ASP345B, ASP345D, ASP374B, ASP374D, ASP405B, ASP405D, CYS375B, CYS375D, GLN285B, GLN285D, GLN396B, GLN396D, GLN401B, GLN401D, GLN8B, GLN8D, GLU278B, GLU278D, GLU344B, GLU344D, GLU384B, GLU384D, GLY347B, GLY347D, GLY397B, GLY397D, ILE348B, ILE348D, LEU15B, LEU15D, LEU282B, LEU282D, LEU29B, LEU29D, LEU341B, LEU341D, LEU343B, LEU343D, LEU380B, LEU380D, LEU383B, LEU383D, LEU387B, LEU387D, LEU390B, LEU390D, LEU9B, LEU9D, LYS340B, LYS340D, LYS373B, LYS373D, LYS391B, LYS391D, MET309D, MET342B, MET342D, MET377B, MET377D, MET400B, MET400D, PHE346B, PHE346D, PHE392B, PHE392D, PRO11B, PRO11D, PRO12B, PRO12D, PRO26B, PRO26D, PRO393B, PRO393D, SER13B, SER13D, SER33B, SER33D, SER381B, SER381D, SER7B, SER7D, THR378B, THR378D, THR379B, THR379D, THR394B, THR394D, THR395B, THR395D, THR4B, TRP404B, TRP404D, TYR369B, TYR369D, TYR389B, TYR389D, TYR407B, TYR407D, VAL28B, VAL28D, VAL376B, VAL376D, VAL386B, VAL386D
• B-H: ALA235B, ALA308H, ALA398H, ARG223B, ARG237B, GLN331H, GLU219B, GLU261B, GLU312H, GLY310H, LYS318H, PHE392H, PRO260B, PRO330H, PRO393H, THR395H
• C-D: ALA107C, ALA107D, ALA112C, ALA112D, ALA24C, ALA24D, ALA269C, ALA269D, ALA272C, ALA272D, ALA280C, ALA280D, ALA31C, ALA31D, ALA43C, ALA43D, ALA53C, ALA53D, ALA75C, ALA75D, ALA79C, ALA79D, ARG108C, ARG108D, ARG109C, ARG109D, ARG111C, ARG111D, ARG14C, ARG14D, ARG224C, ARG224D, ARG232C, ARG232D, ARG262C, ARG262D, ARG277C, ARG277D, ARG27C, ARG27D, ARG281C, ARG281D, ARG30C, ARG30D, ARG339C, ARG339D, ARG363C, ARG363D, ARG372C, ARG56C, ARG56D, ARG74C, ARG74D, ARG98C, ARG98D, ASN10C, ASN10D, ASN23C, ASN23D, ASN247C, ASN247D, ASN264C, ASN264D, ASN370C, ASN49C, ASN49D, ASP238C, ASP238D, ASP250C, ASP250D, ASP25C, ASP25D, ASP2C, ASP2D, ASP41C, ASP41D, ASP70C, ASP70D, CYS104C, CYS104D, CYS110C, CYS110D, CYS226C, CYS226D, GLN199C, GLN199D, GLN285C, GLN285D, GLN35C, GLN35D, GLN39C, GLN39D, GLN5C, GLN5D, GLN8C, GLN8D, GLU105C, GLU105D, GLU228C, GLU228D, GLU229C, GLU229D, GLU242C, GLU242D, GLU268C, GLU268D, GLU278C, GLU278D, GLU286C, GLU286D, GLU344C, GLU344D, GLU349C, GLU349D, GLU50C, GLU50D, GLU78C, GLU78D, GLY100C, GLY100D, GLY18C, GLY18D, GLY197D, GLY203C, GLY203D, GLY204C, GLY204D, GLY207C, GLY207D, GLY20C, GLY20D, GLY230C, GLY230D, GLY252C, GLY252D, GLY275C, GLY275D, GLY287C, GLY287D, GLY347C, GLY347D, GLY351D, GLY355C, GLY355D, GLY38C, GLY38D, GLY57C, GLY57D, GLY71C, GLY71D, GLY76C, GLY76D, GLY97C, GLY97D, HIS101C, HIS101D, HIS265C, HIS265D, HIS266C, HIS266D, HIS46C, HIS46D, ILE106C, ILE106D, ILE22C, ILE22D, ILE231C, ILE231D, ILE244C, ILE244D, ILE283C, ILE283D, ILE37C, ILE37D, ILE3C, ILE3D, ILE77C, ILE77D, LEU102C, LEU102D, LEU103C, LEU103D, LEU15C, LEU15D, LEU16C, LEU16D, LEU251C, LEU251D, LEU263C, LEU263D, LEU273C, LEU273D, LEU282C, LEU282D, LEU284C, LEU284D, LEU29C, LEU29D, LEU343C, LEU343D, LEU36C, LEU36D, LEU54C, LEU54D, LEU81D, LEU9C, LEU9D, LYS225C, LYS225D, LYS340C, LYS340D, MET198C, MET198D, MET243C, MET243D, MET253C, MET253D, MET32C, MET32D, MET44C, MET44D, MET52C, MET52D, PHE249C, PHE249D, PHE274C, PHE274D, PHE354C, PHE354D, PHE6C, PHE6D, PHE99C, PHE99D, PRO11C, PRO11D, PRO12C, PRO12D, PRO19C, PRO19D, PRO205C, PRO205D, PRO21C, PRO21D, PRO26C, PRO26D, PRO356C, PRO356D, PRO42C, PRO42D, PRO87C, PRO87D, SER13C, SER13D, SER206C, SER206D, SER209C, SER246C, SER246D, SER33C, SER33D, SER34C, SER34D, SER73C, SER73D, SER7C, SER7D, THR116C, THR208C, THR208D, THR233C, THR233D, THR267C, THR267D, THR270C, THR270D, THR271C, THR271D, THR352C, THR352D, THR4C, THR4D, THR72C, THR72D, TRP121C, TRP121D, TYR245C, TYR245D, TYR248C, TYR248D, TYR257C, TYR257D, TYR369C, TYR369D, TYR40C, TYR40D, TYR47C, TYR47D, TYR55C, VAL114C, VAL227C, VAL227D, VAL28C, VAL28D, VAL51C, VAL51D, VAL58C, VAL58D, VAL69C, VAL69D, VAL82C, VAL82D, VAL95C
• C-F: ARG408C, ARG411C, GLN331F, GLU410C, GLY332F, PRO330F, SER409C
• E-F: ALA107E, ALA107F, ALA112E, ALA112F, ALA24E, ALA24F, ALA269E, ALA269F, ALA272E, ALA272F, ALA280E, ALA280F, ALA31E, ALA31F, ALA43E, ALA43F, ALA53E, ALA53F, ALA75E, ALA75F, ALA79E, ALA79F, ARG108E, ARG108F, ARG109E, ARG109F, ARG111E, ARG111F, ARG14E, ARG14F, ARG224E, ARG224F, ARG232E, ARG232F, ARG262E, ARG262F, ARG277E, ARG277F, ARG27E, ARG27F, ARG281E, ARG281F, ARG30E, ARG30F, ARG339E, ARG339F, ARG363E, ARG363F, ARG372E, ARG56E, ARG56F, ARG74E, ARG74F, ARG98E, ARG98F, ASN10E, ASN10F, ASN23E, ASN23F, ASN247E, ASN247F, ASN264E, ASN264F, ASN370E, ASN49E, ASN49F, ASP238E, ASP238F, ASP250E, ASP250F, ASP25E, ASP25F, ASP2E, ASP2F, ASP41E, ASP41F, ASP70E, ASP70F, CYS104E, CYS104F, CYS110E, CYS110F, CYS226E, CYS226F, GLN199E, GLN199F, GLN285E, GLN285F, GLN35E, GLN35F, GLN39E, GLN39F, GLN5E, GLN5F, GLN8E, GLN8F, GLU105E, GLU105F, GLU228E, GLU228F, GLU229E, GLU229F, GLU242E, GLU242F, GLU268E, GLU268F, GLU278E, GLU278F, GLU286E, GLU286F, GLU344E, GLU344F, GLU349E, GLU349F, GLU50E, GLU50F, GLU78E, GLU78F, GLY100E, GLY100F, GLY18E, GLY18F, GLY203E, GLY203F, GLY204E, GLY204F, GLY207E, GLY207F, GLY20E, GLY20F, GLY230E, GLY230F, GLY252E, GLY252F, GLY275E, GLY275F, GLY287E, GLY287F, GLY347E, GLY347F, GLY351E, GLY355E, GLY355F, GLY38E, GLY38F, GLY57E, GLY57F, GLY71E, GLY71F, GLY76E, GLY76F, GLY97E, GLY97F, HIS101E, HIS101F, HIS265E, HIS265F, HIS266E, HIS266F, HIS46E, HIS46F, ILE106E, ILE106F, ILE22E, ILE22F, ILE231E, ILE231F, ILE244E, ILE244F, ILE283E, ILE283F, ILE37E, ILE37F, ILE3E, ILE3F, ILE77E, ILE77F, LEU102E, LEU102F, LEU103E, LEU103F, LEU15E, LEU15F, LEU16E, LEU16F, LEU251E, LEU251F, LEU263E, LEU263F, LEU273E, LEU273F, LEU282E, LEU282F, LEU284E, LEU284F, LEU29E, LEU29F, LEU343E, LEU343F, LEU36E, LEU36F, LEU54E, LEU54F, LEU81E, LEU9E, LEU9F, LYS225E, LYS225F, LYS340E, LYS340F, MET17F, MET198E, MET198F, MET243E, MET243F, MET253E, MET253F, MET32E, MET32F, MET44E, MET44F, MET52E, MET52F, PHE249E, PHE249F, PHE274E, PHE274F, PHE354E, PHE354F, PHE6E, PHE6F, PHE99E, PHE99F, PRO11E, PRO11F, PRO12E, PRO12F, PRO19E, PRO19F, PRO205E, PRO205F, PRO21E, PRO21F, PRO26E, PRO26F, PRO356E, PRO356F, PRO42E, PRO42F, PRO87E, PRO87F, SER13E, SER13F, SER206E, SER206F, SER209E, SER209F, SER246E, SER246F, SER33E, SER33F, SER34E, SER34F, SER73E, SER73F, SER7E, SER7F, SER83F, THR116F, THR176E, THR208E, THR208F, THR233E, THR233F, THR267E, THR267F, THR270E, THR270F, THR271E, THR271F, THR352E, THR352F, THR4E, THR4F, THR72E, THR72F, TRP121E, TRP121F, TYR245E, TYR245F, TYR248E, TYR248F, TYR257E, TYR257F, TYR369E, TYR40E, TYR40F, TYR47E, TYR47F, TYR55F, VAL114F, VAL227E, VAL227F, VAL28E, VAL28F, VAL51E, VAL51F, VAL58E, VAL69E, VAL69F, VAL82E, VAL82F, VAL95E, VAL95F
• E-G: ALA31E, ALA338G, ALA382E, ALA382G, ALA385E, ALA385G, ALA398E, ALA398G, ALA399E, ALA399G, ALA402E, ALA402G, ALA403E, ALA403G, ARG14E, ARG14G, ARG277E, ARG27E, ARG27G, ARG281E, ARG281G, ARG30E, ARG30G, ARG372E, ARG372G, ARG408E, ARG408G, ASN10E, ASN10G, ASN370E, ASN370G, ASN388E, ASN388G, ASP25E, ASP25G, ASP345E, ASP345G, ASP374E, ASP374G, ASP405E, ASP405G, CYS375E, CYS375G, GLN285E, GLN285G, GLN35E, GLN35G, GLN396E, GLN396G, GLN401E, GLN401G, GLN8E, GLN8G, GLU278E, GLU278G, GLU344E, GLU344G, GLU384E, GLU384G, GLY347E, GLY347G, GLY397E, GLY397G, ILE348E, ILE348G, LEU15E, LEU15G, LEU282E, LEU282G, LEU29E, LEU29G, LEU341E, LEU341G, LEU343E, LEU343G, LEU380E, LEU380G, LEU383E, LEU383G, LEU387E, LEU387G, LEU390E, LEU390G, LEU9E, LEU9G, LYS340E, LYS340G, LYS373E, LYS373G, LYS391G, MET309E, MET309G, MET342E, MET342G, MET377E, MET377G, MET400E, MET400G, PHE346E, PHE346G, PHE392E, PHE392G, PRO11E, PRO11G, PRO12E, PRO12G, PRO26E, PRO26G, PRO393E, PRO393G, SER13E, SER13G, SER33E, SER33G, SER381E, SER381G, SER7E, SER7G, THR378E, THR378G, THR379E, THR379G, THR394E, THR394G, THR395E, THR395G, THR4E, THR4G, TRP404E, TRP404G, TYR369E, TYR369G, TYR389E, TYR389G, TYR407E, TYR407G, VAL28E, VAL28G, VAL376E, VAL376G, VAL386E, VAL386G
• E-H: ALA31E, ALA31H, ARG27E, ARG27H, ARG281E, ARG281H, ARG30E, ARG30H, GLN285E, GLN285H, GLN35E, GLN35H, GLN5E, GLN5H, GLN8E, GLN8H, LEU29E, LEU29H, LEU9E, LEU9H, MET32E, MET32H, PHE274E, PHE274H, PHE6E, PRO26E, PRO26H, SER13E, SER33E, SER33H, SER34E, SER34H, SER7E, SER7H, THR4E, THR4H, TYR369E, TYR369H, TYR47E, TYR47H, VAL28H
• F-G: ALA24F, ALA31F, ALA31G, ARG27F, ARG27G, ARG281F, ARG281G, ARG30F, ARG30G, ASP25F, GLN285F, GLN285G, GLN35F, GLN35G, GLN5F, GLN5G, GLN8F, GLN8G, LEU29F, LEU29G, LEU36F, LEU9F, LEU9G, MET32F, MET32G, PHE274F, PHE274G, PHE6F, PRO26F, PRO26G, SER13F, SER13G, SER33F, SER33G, SER34F, SER34G, SER7F, SER7G, THR4F, THR4G, TYR369F, TYR369G, TYR47F, TYR47G, VAL28G
• F-H: ALA31F, ALA31H, ALA338F, ALA338H, ALA382F, ALA382H, ALA385F, ALA385H, ALA398F, ALA398H, ALA399F, ALA399H, ALA402F, ALA402H, ALA403F, ALA403H, ARG14F, ARG14H, ARG277F, ARG277H, ARG27F, ARG27H, ARG281F, ARG281H, ARG30F, ARG30H, ARG372F, ARG372H, ARG408F, ARG408H, ASN10F, ASN10H, ASN370F, ASN370H, ASN388F, ASN388H, ASP25F, ASP25H, ASP345F, ASP345H, ASP374F, ASP374H, ASP405F, ASP405H, CYS375F, CYS375H, GLN285F, GLN285H, GLN396F, GLN396H, GLN401F, GLN401H, GLN8F, GLN8H, GLU278F, GLU278H, GLU344F, GLU344H, GLU384F, GLU384H, GLY347F, GLY347H, GLY397F, GLY397H, ILE348F, ILE348H, LEU15F, LEU15H, LEU282F, LEU282H, LEU29F, LEU29H, LEU341F, LEU341H, LEU343F, LEU343H, LEU380F, LEU380H, LEU383F, LEU383H, LEU387F, LEU387H, LEU390F, LEU390H, LEU9F, LEU9H, LYS340H, LYS373F, LYS373H, LYS391F, LYS391H, MET309F, MET342F, MET342H, MET377F, MET377H, MET400F, MET400H, PHE346F, PHE346H, PHE392F, PHE392H, PRO11F, PRO11H, PRO12F, PRO12H, PRO26F, PRO26H, PRO393F, PRO393H, SER13F, SER13H, SER33F, SER33H, SER381F, SER381H, SER7F, SER7H, THR378F, THR378H, THR379F, THR379H, THR394F, THR394H, THR395F, THR395H, THR4H, TRP404F, TRP404H, TYR369F, TYR369H, TYR389F, TYR389H, TYR407F, TYR407H, VAL28F, VAL28H, VAL376F, VAL376H, VAL386F, VAL386H
• G-H: ALA107G, ALA107H, ALA112G, ALA112H, ALA24G, ALA24H, ALA269G, ALA269H, ALA272G, ALA272H, ALA280G, ALA280H, ALA31G, ALA31H, ALA43G, ALA43H, ALA53G, ALA53H, ALA75G, ALA75H, ALA79G, ALA79H, ARG108G, ARG108H, ARG109G, ARG109H, ARG111G, ARG111H, ARG14G, ARG14H, ARG224G, ARG224H, ARG232G, ARG232H, ARG262H, ARG277G, ARG277H, ARG27G, ARG27H, ARG281G, ARG281H, ARG30G, ARG30H, ARG339G, ARG339H, ARG363G, ARG363H, ARG56G, ARG56H, ARG74G, ARG74H, ARG98G, ARG98H, ASN10G, ASN10H, ASN23G, ASN23H, ASN247G, ASN247H, ASN264G, ASN264H, ASN370G, ASN370H, ASN49G, ASN49H, ASP238G, ASP238H, ASP250G, ASP250H, ASP25G, ASP25H, ASP2G, ASP2H, ASP41G, ASP41H, ASP70G, ASP70H, CYS104G, CYS104H, CYS110G, CYS110H, CYS226G, CYS226H, GLN199G, GLN199H, GLN285G, GLN285H, GLN35G, GLN35H, GLN39G, GLN39H, GLN5G, GLN5H, GLN8G, GLN8H, GLU105G, GLU105H, GLU228G, GLU228H, GLU229G, GLU229H, GLU242G, GLU242H, GLU268G, GLU268H, GLU278G, GLU278H, GLU286G, GLU286H, GLU344G, GLU344H, GLU349G, GLU349H, GLU50G, GLU50H, GLU78G, GLU78H, GLY100G, GLY100H, GLY18G, GLY18H, GLY203G, GLY203H, GLY204G, GLY204H, GLY207G, GLY207H, GLY20G, GLY20H, GLY230G, GLY230H, GLY252G, GLY252H, GLY275G, GLY275H, GLY287G, GLY287H, GLY347G, GLY347H, GLY355G, GLY355H, GLY38G, GLY38H, GLY57G, GLY57H, GLY71G, GLY71H, GLY76G, GLY76H, GLY97G, GLY97H, HIS101G, HIS101H, HIS265G, HIS265H, HIS266G, HIS266H, HIS46G, HIS46H, ILE106G, ILE106H, ILE22G, ILE22H, ILE231G, ILE231H, ILE244G, ILE244H, ILE283G, ILE283H, ILE37G, ILE37H, ILE3G, ILE3H, ILE77G, ILE77H, LEU102G, LEU102H, LEU103G, LEU103H, LEU15G, LEU15H, LEU16G, LEU16H, LEU251G, LEU251H, LEU263G, LEU263H, LEU273G, LEU273H, LEU282G, LEU282H, LEU284G, LEU284H, LEU29G, LEU29H, LEU343G, LEU343H, LEU36G, LEU36H, LEU54G, LEU54H, LEU81H, LEU9G, LEU9H, LYS225G, LYS225H, LYS340G, LYS340H, MET198G, MET198H, MET243G, MET243H, MET253G, MET253H, MET32G, MET32H, MET44G, MET44H, MET52G, MET52H, PHE249G, PHE249H, PHE274G, PHE274H, PHE354G, PHE354H, PHE6G, PHE6H, PHE99G, PHE99H, PRO11G, PRO11H, PRO12G, PRO12H, PRO19G, PRO19H, PRO205G, PRO205H, PRO21G, PRO21H, PRO26G, PRO26H, PRO356G, PRO356H, PRO42G, PRO42H, PRO87G, PRO87H, SER13G, SER13H, SER206G, SER206H, SER209G, SER209H, SER246G, SER246H, SER33G, SER33H, SER34G, SER34H, SER73G, SER73H, SER7G, SER7H, SER83G, THR116G, THR176G, THR208G, THR208H, THR233G, THR233H, THR267G, THR267H, THR270G, THR270H, THR271G, THR271H, THR352G, THR352H, THR4G, THR4H, THR72G, THR72H, TRP121G, TRP121H, TYR245G, TYR245H, TYR248G, TYR248H, TYR257G, TYR257H, TYR369G, TYR369H, TYR40G, TYR40H, TYR47G, TYR47H, VAL114G, VAL227G, VAL227H, VAL28G, VAL28H, VAL51G, VAL51H, VAL58H, VAL69G, VAL69H, VAL82G, VAL82H, VAL93G, VAL95G, VAL95H
• J-K: ALA107J, ALA107K, ALA112J, ALA112K, ALA24J, ALA24K, ALA269J, ALA269K, ALA272J, ALA272K, ALA280J, ALA280K, ALA31J, ALA31K, ALA43J, ALA43K, ALA53J, ALA53K, ALA75J, ALA75K, ALA79J, ALA79K, ARG108J, ARG108K, ARG109J, ARG109K, ARG111J, ARG111K, ARG14J, ARG14K, ARG224J, ARG224K, ARG232J, ARG232K, ARG262J, ARG262K, ARG277J, ARG277K, ARG27J, ARG27K, ARG281J, ARG281K, ARG30J, ARG30K, ARG339J, ARG339K, ARG363J, ARG363K, ARG372J, ARG56J, ARG56K, ARG74J, ARG74K, ARG98J, ARG98K, ASN10J, ASN10K, ASN23J, ASN23K, ASN247J, ASN247K, ASN264J, ASN264K, ASN370J, ASN49J, ASN49K, ASP238J, ASP238K, ASP250J, ASP250K, ASP25J, ASP25K, ASP2J, ASP2K, ASP41J, ASP41K, ASP70J, ASP70K, CYS104J, CYS104K, CYS110J, CYS110K, CYS226J, CYS226K, GLN199J, GLN199K, GLN285J, GLN285K, GLN35J, GLN35K, GLN39J, GLN39K, GLN5J, GLN5K, GLN8J, GLN8K, GLU105J, GLU105K, GLU118K, GLU228J, GLU228K, GLU229J, GLU229K, GLU242J, GLU242K, GLU268J, GLU268K, GLU278J, GLU278K, GLU286J, GLU286K, GLU344J, GLU344K, GLU349J, GLU349K, GLU50J, GLU50K, GLU78J, GLU78K, GLY100J, GLY100K, GLY18J, GLY18K, GLY203J, GLY203K, GLY204J, GLY204K, GLY207J, GLY207K, GLY20J, GLY20K, GLY230J, GLY230K, GLY252J, GLY252K, GLY275J, GLY275K, GLY287J, GLY287K, GLY347J, GLY347K, GLY355J, GLY355K, GLY38J, GLY38K, GLY57J, GLY57K, GLY71J, GLY71K, GLY76J, GLY76K, GLY97J, GLY97K, HIS101J, HIS101K, HIS265J, HIS265K, HIS266J, HIS266K, HIS46J, HIS46K, ILE106J, ILE106K, ILE22J, ILE22K, ILE231J, ILE231K, ILE244J, ILE244K, ILE283J, ILE283K, ILE37J, ILE37K, ILE3J, ILE3K, ILE77J, ILE77K, LEU102J, LEU102K, LEU103J, LEU103K, LEU15J, LEU15K, LEU16J, LEU16K, LEU251J, LEU251K, LEU263J, LEU263K, LEU273J, LEU273K, LEU282J, LEU282K, LEU284J, LEU284K, LEU29J, LEU29K, LEU343J, LEU343K, LEU36J, LEU36K, LEU54J, LEU54K, LEU9J, LEU9K, LYS225J, LYS225K, LYS340J, LYS340K, MET198J, MET198K, MET243J, MET243K, MET253J, MET253K, MET32J, MET32K, MET44J, MET44K, MET52J, MET52K, PHE249J, PHE249K, PHE274J, PHE274K, PHE354J, PHE354K, PHE6J, PHE6K, PHE99J, PHE99K, PRO11J, PRO11K, PRO12J, PRO12K, PRO19J, PRO19K, PRO205J, PRO205K, PRO21J, PRO21K, PRO26J, PRO26K, PRO356J, PRO356K, PRO42J, PRO42K, PRO87J, PRO87K, SER13J, SER13K, SER206J, SER206K, SER209K, SER246J, SER246K, SER33J, SER33K, SER34J, SER34K, SER73J, SER73K, SER7J, SER7K, THR116K, THR208J, THR208K, THR233J, THR233K, THR267J, THR267K, THR270J, THR270K, THR271J, THR271K, THR352J, THR352K, THR4J, THR4K, THR72J, THR72K, TRP121J, TRP121K, TYR245J, TYR245K, TYR248J, TYR248K, TYR257J, TYR257K, TYR369J, TYR40J, TYR40K, TYR47J, TYR47K, TYR55K, VAL114K, VAL227J, VAL227K, VAL28J, VAL28K, VAL51J, VAL51K, VAL58J, VAL58K, VAL69J, VAL69K, VAL82J, VAL82K, VAL95K
• J-L: ALA31J, ALA31L, ALA338J, ALA338L, ALA382J, ALA382L, ALA385J, ALA385L, ALA398J, ALA398L, ALA399J, ALA399L, ALA402J, ALA402L, ALA403J, ALA403L, ARG14J, ARG14L, ARG277J, ARG277L, ARG27J, ARG27L, ARG281J, ARG281L, ARG30J, ARG30L, ARG372J, ARG372L, ARG408J, ARG408L, ASN10J, ASN10L, ASN370J, ASN370L, ASN388J, ASN388L, ASP25J, ASP25L, ASP345J, ASP345L, ASP374J, ASP374L, ASP405J, ASP405L, CYS375J, CYS375L, GLN285J, GLN285L, GLN35J, GLN35L, GLN396J, GLN396L, GLN401J, GLN401L, GLN8J, GLN8L, GLU278J, GLU278L, GLU344J, GLU344L, GLU384J, GLU384L, GLY347J, GLY347L, GLY397J, GLY397L, ILE348J, ILE348L, LEU15J, LEU15L, LEU282J, LEU282L, LEU29J, LEU29L, LEU341J, LEU341L, LEU343J, LEU343L, LEU380J, LEU380L, LEU383J, LEU383L, LEU387J, LEU387L, LEU390J, LEU390L, LEU9J, LEU9L, LYS340J, LYS373J, LYS373L, LYS391J, MET309J, MET342J, MET342L, MET377J, MET377L, MET400J, MET400L, PHE346J, PHE346L, PHE392J, PHE392L, PRO11J, PRO11L, PRO12J, PRO12L, PRO26J, PRO26L, PRO393J, PRO393L, SER13J, SER13L, SER33J, SER33L, SER381J, SER381L, SER7J, SER7L, THR378J, THR378L, THR379J, THR379L, THR394J, THR394L, THR395J, THR395L, THR4J, THR4L, TRP404J, TRP404L, TYR369J, TYR369L, TYR389J, TYR389L, TYR407J, TYR407L, VAL28J, VAL28L, VAL376J, VAL376L, VAL386J, VAL386L
• J-M: ALA31J, ALA31M, ARG27J, ARG27M, ARG281J, ARG281M, ARG30J, ARG30M, ASP2J, GLN285J, GLN35J, GLN35M, GLN5J, GLN5M, GLN8J, GLN8M, LEU29J, LEU29M, LEU9J, LEU9M, MET32J, MET32M, PHE274J, PHE274M, PHE6M, PRO26J, PRO26M, SER13J, SER33J, SER33M, SER34J, SER34M, SER7J, SER7M, THR4J, THR4M, TYR369J, TYR369M, TYR47J, TYR47M, VAL28M
• J-R: ASP234R, LYS296J
• J-S: ALA398J, ALA402J, ALA403J, ARG408J, ARG411J, ASN334S, ASP336S, ASP405J, GLN331S, GLN401J, GLU312S, GLU410J, GLY332S, GLY335S, GLY355S, GLY359S, GLY397J, HIS358S, HIS406J, ILE329S, ILE333S, LEU357S, LYS304J, LYS360S, PRO330S, PRO356S, SER353S, SER409J, TRP404J, TYR407J, VAL328S, VAL361S
• K-L: ALA24K, ALA31K, ALA31L, ARG27K, ARG27L, ARG281K, ARG281L, ARG30K, ARG30L, ARG372K, ASN23K, ASP25K, GLN285K, GLN285L, GLN35K, GLN35L, GLN5K, GLN5L, GLN8K, GLN8L, LEU29K, LEU29L, LEU36L, LEU9K, LEU9L, MET32K, MET32L, PHE274K, PHE274L, PHE6K, PHE6L, PRO26K, PRO26L, SER13K, SER13L, SER33K, SER33L, SER34K, SER34L, SER7K, SER7L, THR4K, THR4L, TYR369K, TYR369L, TYR47K, TYR47L
• K-M: ALA31K, ALA31M, ALA338M, ALA382K, ALA382M, ALA385K, ALA385M, ALA398K, ALA398M, ALA399K, ALA399M, ALA402K, ALA402M, ALA403K, ALA403M, ARG14K, ARG14M, ARG277K, ARG277M, ARG27K, ARG27M, ARG281K, ARG281M, ARG30K, ARG30M, ARG372K, ARG372M, ARG408K, ARG408M, ASN10K, ASN10M, ASN370K, ASN370M, ASN388K, ASN388M, ASP25K, ASP25M, ASP345K, ASP345M, ASP374K, ASP374M, ASP405K, ASP405M, CYS375K, CYS375M, GLN285K, GLN285M, GLN396K, GLN396M, GLN401K, GLN401M, GLN8K, GLN8M, GLU278K, GLU278M, GLU344K, GLU344M, GLU384K, GLU384M, GLY347K, GLY347M, GLY397K, GLY397M, ILE348K, ILE348M, LEU15K, LEU15M, LEU282K, LEU282M, LEU29K, LEU29M, LEU341K, LEU341M, LEU343K, LEU343M, LEU380K, LEU380M, LEU383K, LEU383M, LEU387K, LEU387M, LEU390K, LEU390M, LEU9K, LEU9M, LYS340K, LYS340M, LYS373K, LYS373M, LYS391K, LYS391M, MET309K, MET309M, MET342K, MET342M, MET377K, MET377M, MET400K, MET400M, PHE346K, PHE346M, PHE392K, PHE392M, PHE6M, PRO11K, PRO11M, PRO12K, PRO12M, PRO26K, PRO26M, PRO393K, PRO393M, SER13K, SER13M, SER33K, SER33M, SER381K, SER381M, SER7K, SER7M, THR378K, THR378M, THR379K, THR379M, THR394K, THR394M, THR395K, THR395M, THR4M, TRP404K, TRP404M, TYR369K, TYR369M, TYR389K, TYR389M, TYR407K, TYR407M, VAL28K, VAL28M, VAL376K, VAL376M, VAL386K, VAL386M
• L-M: ALA107L, ALA107M, ALA112L, ALA112M, ALA24L, ALA24M, ALA269L, ALA269M, ALA272L, ALA272M, ALA276L, ALA276M, ALA280L, ALA280M, ALA31L, ALA31M, ALA43L, ALA43M, ALA53L, ALA53M, ALA75L, ALA75M, ALA79L, ALA79M, ARG108L, ARG108M, ARG109L, ARG109M, ARG111L, ARG111M, ARG14L, ARG14M, ARG224L, ARG224M, ARG232L, ARG232M, ARG262L, ARG262M, ARG277L, ARG277M, ARG27L, ARG27M, ARG281L, ARG281M, ARG30L, ARG30M, ARG339L, ARG339M, ARG363L, ARG363M, ARG372L, ARG56L, ARG74L, ARG74M, ARG98L, ARG98M, ASN10L, ASN10M, ASN23L, ASN23M, ASN247L, ASN247M, ASN264L, ASN264M, ASN370L, ASN49L, ASN49M, ASP238L, ASP238M, ASP250L, ASP250M, ASP25L, ASP25M, ASP2M, ASP41L, ASP41M, ASP70L, ASP70M, CYS104L, CYS104M, CYS110L, CYS110M, CYS226L, CYS226M, CYS279L, GLN199L, GLN199M, GLN285L, GLN285M, GLN35L, GLN35M, GLN39L, GLN39M, GLN5L, GLN5M, GLN8L, GLN8M, GLU105L, GLU105M, GLU228L, GLU228M, GLU229L, GLU229M, GLU242L, GLU242M, GLU268L, GLU268M, GLU278L, GLU278M, GLU286L, GLU286M, GLU344L, GLU344M, GLU349L, GLU349M, GLU50L, GLU50M, GLU78L, GLU78M, GLY100L, GLY100M, GLY18L, GLY18M, GLY203L, GLY203M, GLY204L, GLY204M, GLY207L, GLY207M, GLY20L, GLY20M, GLY230L, GLY230M, GLY252L, GLY252M, GLY275L, GLY275M, GLY287L, GLY287M, GLY347L, GLY347M, GLY355L, GLY355M, GLY38L, GLY38M, GLY57L, GLY57M, GLY71L, GLY71M, GLY76L, GLY76M, GLY97L, GLY97M, HIS101L, HIS101M, HIS265L, HIS265M, HIS266L, HIS266M, HIS46L, HIS46M, ILE106L, ILE106M, ILE22L, ILE22M, ILE231M, ILE244L, ILE244M, ILE283L, ILE283M, ILE37L, ILE37M, ILE3L, ILE3M, ILE77L, ILE77M, LEU102L, LEU102M, LEU103L, LEU103M, LEU15L, LEU15M, LEU16L, LEU16M, LEU251L, LEU251M, LEU263L, LEU263M, LEU273L, LEU273M, LEU282L, LEU282M, LEU284L, LEU284M, LEU29L, LEU29M, LEU343L, LEU343M, LEU36L, LEU36M, LEU54L, LEU54M, LEU81M, LEU9L, LEU9M, LYS225L, LYS225M, LYS340L, LYS340M, MET198L, MET198M, MET243L, MET243M, MET253L, MET253M, MET32L, MET32M, MET44L, MET44M, MET52L, MET52M, PHE249L, PHE249M, PHE274L, PHE274M, PHE354L, PHE354M, PHE6L, PHE6M, PHE99L, PHE99M, PRO11L, PRO11M, PRO12L, PRO12M, PRO19L, PRO19M, PRO205L, PRO205M, PRO21L, PRO21M, PRO26L, PRO26M, PRO356L, PRO42L, PRO42M, PRO87L, PRO87M, SER13L, SER13M, SER206L, SER206M, SER209L, SER209M, SER246L, SER246M, SER33L, SER33M, SER34L, SER34M, SER73L, SER73M, SER7L, SER7M, THR116L, THR176L, THR208L, THR208M, THR233L, THR233M, THR267L, THR267M, THR270L, THR270M, THR271L, THR271M, THR352L, THR352M, THR4L, THR4M, THR72L, THR72M, TRP121L, TRP121M, TYR245L, TYR245M, TYR248L, TYR248M, TYR257L, TYR257M, TYR369L, TYR369M, TYR40L, TYR40M, TYR47L, TYR47M, TYR55L, VAL114L, VAL227L, VAL227M, VAL28L, VAL28M, VAL51L, VAL51M, VAL58L, VAL58M, VAL69L, VAL69M, VAL82L, VAL82M, VAL95L
• L-S: ASN334L, ASN334S, ASN388L, ASP345L, GLN331S, GLN337L, GLN337S, GLU312S, GLY310S, GLY332S, ILE329S, ILE333S, LEU311S, LEU341L, LEU387S, LEU390L, LYS340L, LYS360S, LYS391L, MET309S, PRO330S, TYR389L, VAL386L
• O-P: ALA107O, ALA107P, ALA112O, ALA112P, ALA24O, ALA24P, ALA269O, ALA269P, ALA272O, ALA272P, ALA276O, ALA280O, ALA280P, ALA31O, ALA31P, ALA43O, ALA43P, ALA53O, ALA53P, ALA75O, ALA75P, ALA79O, ALA79P, ARG108O, ARG108P, ARG109O, ARG109P, ARG111O, ARG111P, ARG14O, ARG14P, ARG224O, ARG224P, ARG232O, ARG232P, ARG262O, ARG262P, ARG277O, ARG277P, ARG27O, ARG27P, ARG281O, ARG281P, ARG30O, ARG30P, ARG339O, ARG339P, ARG363O, ARG363P, ARG372O, ARG56O, ARG56P, ARG74O, ARG74P, ARG98O, ARG98P, ASN10O, ASN10P, ASN23O, ASN23P, ASN247O, ASN247P, ASN264O, ASN264P, ASN370O, ASN370P, ASN49O, ASN49P, ASP238O, ASP238P, ASP250O, ASP250P, ASP25O, ASP25P, ASP2O, ASP2P, ASP41O, ASP41P, ASP70O, ASP70P, CYS104O, CYS104P, CYS110O, CYS110P, CYS226O, CYS226P, CYS279O, GLN199O, GLN199P, GLN285O, GLN285P, GLN35O, GLN35P, GLN39O, GLN39P, GLN5O, GLN5P, GLN8O, GLN8P, GLU105O, GLU105P, GLU118P, GLU228O, GLU228P, GLU229O, GLU229P, GLU242O, GLU242P, GLU268O, GLU268P, GLU278O, GLU278P, GLU286O, GLU286P, GLU344O, GLU344P, GLU349O, GLU349P, GLU50O, GLU50P, GLU78O, GLU78P, GLY100O, GLY100P, GLY18O, GLY18P, GLY203O, GLY203P, GLY204O, GLY204P, GLY207O, GLY207P, GLY20O, GLY20P, GLY230O, GLY230P, GLY252O, GLY252P, GLY275O, GLY275P, GLY287O, GLY287P, GLY347O, GLY347P, GLY355O, GLY355P, GLY38O, GLY38P, GLY57O, GLY57P, GLY71O, GLY71P, GLY76O, GLY76P, GLY97O, GLY97P, HIS101O, HIS101P, HIS265O, HIS265P, HIS266O, HIS266P, HIS46O, HIS46P, ILE106O, ILE106P, ILE22O, ILE22P, ILE231O, ILE231P, ILE244O, ILE244P, ILE283O, ILE283P, ILE37O, ILE37P, ILE3O, ILE3P, ILE77O, ILE77P, LEU102O, LEU102P, LEU103O, LEU103P, LEU15O, LEU15P, LEU16O, LEU16P, LEU251O, LEU251P, LEU263O, LEU263P, LEU273O, LEU273P, LEU282O, LEU282P, LEU284O, LEU284P, LEU29O, LEU29P, LEU343O, LEU343P, LEU36O, LEU36P, LEU54O, LEU54P, LEU81O, LEU9O, LEU9P, LYS225O, LYS225P, LYS340O, LYS340P, MET198O, MET198P, MET243O, MET243P, MET253O, MET253P, MET32O, MET32P, MET44O, MET44P, MET52O, MET52P, PHE249O, PHE249P, PHE274O, PHE274P, PHE354O, PHE354P, PHE6O, PHE6P, PHE99O, PHE99P, PRO11O, PRO11P, PRO12O, PRO12P, PRO19O, PRO19P, PRO205O, PRO205P, PRO21O, PRO21P, PRO26O, PRO26P, PRO356O, PRO356P, PRO42O, PRO42P, PRO87O, PRO87P, SER13O, SER13P, SER206O, SER206P, SER209O, SER246O, SER246P, SER33O, SER33P, SER34O, SER34P, SER73O, SER73P, SER7O, SER7P, SER83O, SER83P, THR116P, THR208O, THR208P, THR233O, THR233P, THR267O, THR267P, THR270O, THR270P, THR271O, THR271P, THR352O, THR352P, THR4O, THR4P, THR72O, THR72P, TRP121O, TRP121P, TYR245O, TYR245P, TYR248O, TYR248P, TYR257O, TYR257P, TYR369O, TYR40O, TYR40P, TYR47O, TYR47P, VAL114P, VAL227O, VAL227P, VAL28O, VAL28P, VAL51O, VAL51P, VAL58O, VAL58P, VAL69O, VAL69P, VAL82O, VAL82P, VAL95O, VAL95P
• O-R: ALA31O, ALA31R, ALA338O, ALA338R, ALA382O, ALA382R, ALA385O, ALA385R, ALA398O, ALA398R, ALA399O, ALA399R, ALA402O, ALA402R, ALA403O, ALA403R, ARG14O, ARG14R, ARG277O, ARG27O, ARG27R, ARG281O, ARG281R, ARG30O, ARG30R, ARG372O, ARG372R, ARG408O, ARG408R, ASN10O, ASN10R, ASN370O, ASN370R, ASN388O, ASN388R, ASP25O, ASP25R, ASP345O, ASP345R, ASP374O, ASP374R, ASP405O, ASP405R, CYS375O, CYS375R, GLN285O, GLN285R, GLN35O, GLN35R, GLN396O, GLN396R, GLN401O, GLN401R, GLN8O, GLN8R, GLU278O, GLU278R, GLU344O, GLU344R, GLU384O, GLU384R, GLY347O, GLY347R, GLY397O, GLY397R, ILE348O, ILE348R, LEU15O, LEU15R, LEU282O, LEU282R, LEU29O, LEU29R, LEU341O, LEU341R, LEU343O, LEU343R, LEU380O, LEU380R, LEU383O, LEU383R, LEU387O, LEU387R, LEU390O, LEU390R, LEU9O, LEU9R, LYS340O, LYS340R, LYS373O, LYS373R, LYS391O, MET309O, MET309R, MET342O, MET342R, MET377O, MET377R, MET400O, MET400R, PHE346O, PHE346R, PHE392O, PHE392R, PRO11O, PRO11R, PRO12O, PRO12R, PRO26O, PRO26R, PRO393O, PRO393R, SER13O, SER13R, SER33O, SER33R, SER381O, SER381R, SER7O, SER7R, THR378O, THR378R, THR379O, THR379R, THR394O, THR394R, THR395O, THR395R, THR4R, TRP404O, TRP404R, TYR369O, TYR369R, TYR389O, TYR389R, TYR407O, TYR407R, VAL28O, VAL28R, VAL376O, VAL376R, VAL386O, VAL386R
• O-S: ALA31O, ALA31S, ARG27O, ARG27S, ARG281O, ARG281S, ARG30O, ARG30S, ASP2O, GLN285O, GLN285S, GLN35O, GLN35S, GLN5O, GLN5S, GLN8O, GLN8S, LEU29O, LEU29S, LEU9O, LEU9S, MET32O, MET32S, PHE274O, PHE274S, PHE6O, PRO26O, PRO26S, SER13O, SER33O, SER33S, SER34O, SER34S, SER7O, SER7S, THR4O, THR4S, TYR369O, TYR369S, TYR47O, TYR47S
• P-R: ALA31P, ALA31R, ARG27P, ARG27R, ARG281P, ARG281R, ARG30P, ARG30R, ASN23P, GLN285P, GLN35P, GLN35R, GLN5P, GLN5R, GLN8P, GLN8R, LEU29P, LEU29R, LEU9P, LEU9R, MET32P, MET32R, PHE274P, PHE274R, PHE6P, PHE6R, PRO26P, PRO26R, SER13P, SER13R, SER33P, SER33R, SER34P, SER34R, SER7P, SER7R, THR4P, THR4R, TYR369P, TYR369R, TYR47P, TYR47R, VAL28R
• P-S: ALA31P, ALA31S, ALA338S, ALA382P, ALA382S, ALA385P, ALA385S, ALA398P, ARG14P, ARG14S, ARG277P, ARG277S, ARG27P, ARG27S, ARG281P, ARG281S, ARG30P, ARG30S, ARG372P, ARG372S, ARG408P, ASN10P, ASN10S, ASN23P, ASN370P, ASN370S, ASN388P, ASN388S, ASP25P, ASP25S, ASP345P, ASP345S, ASP374P, ASP374S, CYS375P, CYS375S, GLN285P, GLN285S, GLN396P, GLN401P, GLN8P, GLN8S, GLU278P, GLU278S, GLU344P, GLU344S, GLU384P, GLU384S, GLY347P, GLY347S, GLY397P, ILE348P, ILE348S, LEU15P, LEU15S, LEU282P, LEU282S, LEU29P, LEU29S, LEU341P, LEU341S, LEU343P, LEU343S, LEU380P, LEU380S, LEU383P, LEU383S, LEU387S, LEU9P, LEU9S, LYS340P, LYS373P, LYS373S, MET309S, MET342P, MET342S, MET377P, MET377S, MET400P, PHE346P, PHE346S, PRO11P, PRO11S, PRO12P, PRO12S, PRO26P, PRO26S, SER13P, SER13S, SER33P, SER33S, SER381P, SER381S, SER7P, SER7S, THR378P, THR378S, THR379P, THR379S, THR395P, THR4S, TRP404P, TYR369P, TYR369S, TYR389P, TYR389S, TYR407P, VAL28P, VAL28S, VAL376P, VAL376S, VAL386P, VAL386S
• R-S: ALA107R, ALA107S, ALA112R, ALA112S, ALA24R, ALA24S, ALA269R, ALA269S, ALA272R, ALA272S, ALA280R, ALA280S, ALA31R, ALA31S, ALA43R, ALA43S, ALA53R, ALA53S, ALA75R, ALA75S, ALA79R, ALA79S, ARG108R, ARG108S, ARG109R, ARG109S, ARG111R, ARG111S, ARG14R, ARG14S, ARG224R, ARG224S, ARG232R, ARG232S, ARG262S, ARG277R, ARG277S, ARG27R, ARG27S, ARG281R, ARG281S, ARG30R, ARG30S, ARG339R, ARG339S, ARG363R, ARG363S, ARG372R, ARG56R, ARG74R, ARG74S, ARG98R, ARG98S, ASN10R, ASN10S, ASN23R, ASN23S, ASN247R, ASN247S, ASN264R, ASN264S, ASN370R, ASN49R, ASN49S, ASP238R, ASP238S, ASP250R, ASP250S, ASP25R, ASP25S, ASP2R, ASP2S, ASP41R, ASP41S, ASP70R, ASP70S, CYS104R, CYS104S, CYS110R, CYS110S, CYS226R, CYS226S, GLN199R, GLN199S, GLN285R, GLN285S, GLN35R, GLN35S, GLN39R, GLN39S, GLN5R, GLN5S, GLN8R, GLN8S, GLU105R, GLU105S, GLU228R, GLU228S, GLU229R, GLU229S, GLU242R, GLU242S, GLU268R, GLU268S, GLU278R, GLU278S, GLU286R, GLU286S, GLU344R, GLU344S, GLU349R, GLU349S, GLU50R, GLU50S, GLU78R, GLU78S, GLY100R, GLY100S, GLY18R, GLY18S, GLY197R, GLY203R, GLY203S, GLY204R, GLY204S, GLY207R, GLY207S, GLY20R, GLY20S, GLY230R, GLY230S, GLY252R, GLY252S, GLY275R, GLY275S, GLY287R, GLY287S, GLY347R, GLY347S, GLY355R, GLY355S, GLY38R, GLY38S, GLY57R, GLY57S, GLY71R, GLY71S, GLY76R, GLY76S, GLY97R, GLY97S, HIS101R, HIS101S, HIS265R, HIS265S, HIS266R, HIS266S, HIS46R, HIS46S, ILE106R, ILE106S, ILE22R, ILE22S, ILE231R, ILE231S, ILE244R, ILE244S, ILE283R, ILE283S, ILE37R, ILE37S, ILE3R, ILE3S, ILE77R, ILE77S, LEU102R, LEU102S, LEU103R, LEU103S, LEU15R, LEU15S, LEU16R, LEU16S, LEU251R, LEU251S, LEU263R, LEU263S, LEU273R, LEU273S, LEU282R, LEU282S, LEU284R, LEU284S, LEU29R, LEU29S, LEU343R, LEU343S, LEU36R, LEU36S, LEU54R, LEU54S, LEU81R, LEU81S, LEU9R, LEU9S, LYS225R, LYS225S, LYS340R, LYS340S, MET198R, MET198S, MET243R, MET243S, MET253R, MET253S, MET32R, MET32S, MET44R, MET44S, MET52R, MET52S, PHE249R, PHE249S, PHE274R, PHE274S, PHE354R, PHE354S, PHE6R, PHE6S, PHE99R, PHE99S, PRO11R, PRO11S, PRO12R, PRO12S, PRO19R, PRO19S, PRO205R, PRO205S, PRO21R, PRO21S, PRO26R, PRO26S, PRO356R, PRO356S, PRO42R, PRO42S, PRO87R, PRO87S, SER13R, SER13S, SER206R, SER206S, SER209R, SER246R, SER246S, SER33R, SER33S, SER34R, SER34S, SER73R, SER73S, SER7R, SER7S, SER83S, THR116R, THR208R, THR208S, THR233R, THR233S, THR267R, THR267S, THR270R, THR270S, THR271R, THR271S, THR352R, THR352S, THR4R, THR4S, THR72R, THR72S, TRP121R, TRP121S, TYR245R, TYR245S, TYR248R, TYR248S, TYR257R, TYR257S, TYR369R, TYR369S, TYR40R, TYR40S, TYR47R, TYR47S, VAL114R, VAL227R, VAL227S, VAL28R, VAL28S, VAL51R, VAL51S, VAL58S, VAL69R, VAL69S, VAL82R, VAL82S, VAL95R