3NKX

impaired binding of 14-3-3 to raf1 is linked to noonan and leopard syndrome

• Total interactions analyzed: 6
• Total true interactions: 3
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 105
  • Norm. En. per Res.: -2.562
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-28.0098	-28.3783	-212.617	-269.0051	105	9	12	9123	10	55	54
A-P	-25.5017	7.2941	-140.391	-158.5986	67	16	0	5518	0	10	8
B-Q	-22.3222	22.7047	-111.416	-111.0335	59	9	0	4657	0	3	3

Interface residues

• A-B: ALA10A, ALA10B, ALA13A, ALA13B, ALA16A, ALA16B, ALA24A, ALA24B, ALA54A, ALA54B, ALA79A, ALA79B, ARG18A, ARG18B, ARG55A, ARG55B, ARG60A, ARG60B, ARG80A, ARG80B, ARG83A, ARG83B, ASN4A, ASN4B, ASP20A, ASP20B, ASP21A, ASP21B, ASP2A, ASP2B, CYS25A, CYS25B, GLN15A, GLN15B, GLN76A, GLN76B, GLN77A, GLN77B, GLN8A, GLN8B, GLU14A, GLU14B, GLU17A, GLU17B, GLU5A, GLU5B, GLU66A, GLU66B, GLU81A, GLU81B, GLU87A, GLU87B, GLU89A, GLU89B, ILE65A, ILE65B, ILE86A, ILE86B, ILE93A, ILE93B, LEU12A, LEU12B, LEU6A, LEU6B, LEU90A, LEU90B, LYS11A, LYS11B, LYS68A, LYS74A, LYS74B, LYS75A, LYS75B, LYS85A, LYS85B, LYS9A, LYS9B, MET1B, MET22A, MET22B, MET78A, MET78B, SER57A, SER57B, SER58A, SER58B, SER63A, SER63B, SER64A, SER64B, THR69A, THR69B, THR88A, TRP59A, TRP59B, TYR19A, TYR19B, TYR82A, TYR82B, VAL61A, VAL61B, VAL62A, VAL62B, VAL7A, VAL7B
• A-P: ALA171A, ALA188A, ALA47A, ARG127A, ARG256P, ARG41A, ARG56A, ARG60A, ASN173A, ASN224A, ASN262P, ASN38A, ASN42A, ASN50A, ASP124A, ASP213A, ASP223A, GLN219A, GLU131A, GLU14A, GLU180A, GLU209A, GLU39A, GLU40A, GLY169A, GLY53A, HIS264P, ILE166A, ILE217A, LEU168A, LEU170A, LEU172A, LEU216A, LEU220A, LEU221A, LEU225A, LEU227A, LEU43A, LEU44A, LYS11A, LYS120A, LYS212A, LYS49A, MET22A, PHE117A, PHE174A, PHE177A, PRO165A, PRO261P, SER175A, SER210A, SER214A, SER257P, SER45A, SER57A, THR258P, THR260P, TRP228A, TRP59A, TYR128A, TYR179A, TYR19A, TYR48A, VAL176A, VAL263P, VAL46A, VAL51A
• B-Q: ALA171B, ALA188B, ALA47B, ARG127B, ARG256Q, ARG41B, ARG56B, ARG60B, ASN173B, ASN224B, ASN262Q, ASN38B, ASN42B, ASN50B, ASP124B, ASP213B, ASP223B, GLN219B, GLU131B, GLU14B, GLU180B, GLU209B, GLY169B, GLY53B, ILE166B, ILE181B, ILE217B, LEU168B, LEU170B, LEU172B, LEU216B, LEU220B, LEU221B, LEU227B, LYS120B, LYS212B, LYS49B, MET22B, PHE117B, PHE174B, PHE177B, PRO165B, PRO261Q, SER175B, SER210B, SER257Q, SER45B, SER57B, THR258Q, THR260Q, TRP228B, TYR128B, TYR149B, TYR179B, TYR19B, VAL176B, VAL263Q, VAL46B, VAL51B