3NJP

the extracellular and transmembrane domain interfaces in epidermal growth factor receptor signaling

• Total interactions analyzed: 6
• Total true interactions: 3
• Strongest Interaction:
  • Chains: A-C
  • Int. Res.: 140
  • Norm. En. per Res.: -3.8212
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-45.9133	36.3692	-373.126	-382.6701	189	20	3	14917	1	35	30
A-C	-63.9794	-75.2019	-395.784	-534.9653	140	22	14	16855	4	31	31
B-D	-61.6211	-73.5614	-404.093	-539.2755	144	24	13	16943	4	31	32

Interface residues

• A-B: ALA192A, ALA192B, ALA265A, ALA265B, ALA286A, ALA286B, ALA573A, ALA573B, ALA62A, ALA62B, ARG200A, ARG200B, ARG220A, ARG220B, ARG228A, ARG228B, ARG231A, ARG231B, ARG285A, ARG285B, ARG405A, ARG405B, ARG84A, ARG84B, ASN210A, ASN210B, ASN247A, ASN247B, ASN256A, ASN256B, ASN580A, ASN580B, ASN86A, ASN86B, ASP206A, ASP206B, ASP223A, ASP238A, ASP238B, ASP279A, ASP279B, ASP290B, CYS195A, CYS195B, CYS207A, CYS207B, CYS240A, CYS240B, CYS267B, CYS271A, CYS283A, CYS283B, CYS287A, CYS287B, CYS302A, CYS302B, CYS305A, CYS305B, CYS604A, CYS604B, CYS612A, GLN193A, GLN193B, GLN194A, GLN194B, GLN252A, GLN252B, GLN8A, GLU221A, GLU221B, GLU306A, GLU306B, GLY218A, GLY218B, GLY264A, GLY264B, GLY281A, GLY281B, GLY288A, GLY288B, GLY574A, GLY574B, GLY603A, GLY603B, GLY63A, HIS209A, HIS209B, HIS280A, HIS280B, ILE318A, ILE318B, LEU243A, LEU243B, LEU245A, LEU245B, LEU38A, LEU38B, LEU582A, LEU582B, LYS229A, LYS229B, LYS301A, LYS301B, LYS303A, LYS303B, LYS304A, LYS304B, LYS322B, LYS569A, LYS569B, MET244A, MET244B, MET253A, MET253B, MET576A, MET576B, MET87A, MET87B, PHE230A, PHE230B, PHE263A, PHE263B, PRO204A, PRO204B, PRO219A, PRO219B, PRO241A, PRO241B, PRO242A, PRO242B, PRO248A, PRO248B, PRO272A, PRO272B, PRO572A, PRO572B, PRO613A, PRO613B, SER196A, SER196B, SER203A, SER203B, SER205A, SER205B, SER262A, SER262B, SER282A, SER282B, SER342A, SER342B, THR239A, THR239B, THR249A, THR249B, THR250A, THR250B, THR266A, THR266B, THR278A, THR278B, THR406A, THR406B, THR570A, THR601A, THR601B, THR605A, THR605B, THR614A, THR614B, TRP584A, TRP584B, TYR246A, TYR246B, TYR251A, TYR251B, TYR261A, TYR261B, TYR275A, TYR275B, TYR292B, TYR602A, TYR602B, VAL276A, VAL276B, VAL284A, VAL284B, VAL575A, VAL575B, VAL583B
• A-C: ALA25C, ALA30C, ALA351A, ALA385A, ALA415A, ALA68A, ALA96A, ARG125A, ARG29A, ARG353A, ARG41C, ARG45C, ASN100A, ASN128A, ASN12A, ASN32C, ASN442A, ASN469A, ASN70A, ASP11C, ASP17C, ASP22A, ASP27C, ASP323A, ASP355A, ASP436A, ASP46C, CYS14C, CYS20C, CYS31C, CYS33C, CYS42C, CYS6C, CYS7A, GLN16A, GLN28A, GLN384A, GLN408A, GLN411A, GLN43C, GLN8A, GLU21A, GLU24C, GLU40C, GLU42A, GLU51C, GLU90A, GLY12C, GLY18A, GLY18C, GLY317A, GLY354A, GLY36C, GLY39C, GLY410A, GLY441A, GLY9A, HIS10C, HIS16C, HIS23A, HIS346A, HIS359A, HIS409A, ILE23C, ILE316A, ILE347A, ILE383A, ILE38C, ILE438A, ILE439A, ILE466A, ILE467A, ILE67A, LEU14A, LEU15C, LEU17A, LEU25A, LEU26C, LEU325A, LEU345A, LEU348A, LEU381A, LEU382A, LEU414A, LEU47C, LEU66A, LEU69A, LEU8C, LEU98A, LYS13A, LYS28C, LYS322A, LYS407A, LYS463A, LYS465A, LYS48C, MET21C, MET30A, PHE20A, PHE357A, PHE380A, PHE412A, PRO349A, PRO7C, SER11A, SER127A, SER26A, SER324A, SER326A, SER356A, SER413A, SER418A, SER440A, SER468A, SER99A, SER9C, THR10A, THR15A, THR19A, THR358A, THR360A, THR44A, TRP49C, TRP50C, TYR101A, TYR13C, TYR29C, TYR37C, TYR44C, TYR45A, TYR64A, TYR89A, VAL19C, VAL34C, VAL350A, VAL35C, VAL416A, VAL417A, VAL437A, VAL97A
• B-D: ALA25D, ALA30D, ALA351B, ALA385B, ALA415B, ALA68B, ALA96B, ARG125B, ARG29B, ARG353B, ARG41D, ARG45D, ARG470B, ASN100B, ASN128B, ASN12B, ASN32B, ASN32D, ASN442B, ASN469B, ASN70B, ASP11D, ASP17D, ASP22B, ASP27D, ASP323B, ASP355B, ASP436B, ASP46D, CYS14D, CYS20D, CYS31D, CYS33D, CYS42D, CYS6D, CYS7B, GLN16B, GLN28B, GLN384B, GLN408B, GLN411B, GLN43D, GLN8B, GLU21B, GLU24D, GLU40D, GLU42B, GLU51D, GLU90B, GLY12D, GLY18B, GLY18D, GLY317B, GLY354B, GLY36D, GLY39D, GLY410B, GLY441B, GLY9B, HIS10D, HIS16D, HIS23B, HIS346B, HIS359B, HIS409B, ILE23D, ILE316B, ILE347B, ILE383B, ILE38D, ILE438B, ILE439B, ILE466B, ILE467B, ILE67B, LEU14B, LEU15D, LEU17B, LEU25B, LEU26D, LEU325B, LEU345B, LEU348B, LEU381B, LEU382B, LEU414B, LEU47D, LEU66B, LEU69B, LEU8D, LEU98B, LYS105B, LYS13B, LYS28D, LYS407B, LYS463B, LYS465B, LYS48D, MET21D, MET30B, PHE20B, PHE31B, PHE357B, PHE380B, PHE412B, PRO349B, PRO7D, SER11B, SER127B, SER26B, SER324B, SER326B, SER356B, SER413B, SER418B, SER440B, SER468B, SER99B, SER9D, THR10B, THR15B, THR19B, THR358B, THR360B, THR44B, TRP49D, TRP50D, TYR101B, TYR13D, TYR22D, TYR29D, TYR37D, TYR44D, TYR45B, TYR89B, VAL19D, VAL34D, VAL350B, VAL35D, VAL416B, VAL417B, VAL437B, VAL6B, VAL97B