3NGB

crystal structure of broadly and potently neutralizing antibody vrc01 in complex with hiv-1 gp120

• Total interactions analyzed: 66
• Total true interactions: 26
• Strongest Interaction:
  • Chains: I-J
  • Int. Res.: 102
  • Norm. En. per Res.: -2.6714
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
G-H	-55.1101	-11.526	-188.25	-254.8861	100	11	1	8308	5	20	15
G-L	-9.6238	0.0	-55.7277	-65.3515	30	2	0	1974	0	2	2
G-E	-12.6791	0.0	-88.3934	-101.0725	67	6	1	4493	0	6	5
G-F	0.0	0.0	-0.2948	-0.2948	5	0	0	50	0	0	0
H-L	-7.8144	-24.0374	376.098	344.2463	182	19	9	17545	2	26	20
H-A	-10.6492	3.268	-28.3371	-35.7183	23	2	0	1867	0	2	2
H-D	-11.6793	0.797	-126.375	-137.2573	80	7	2	6306	0	7	8
H-E	0.0	-8.0709	-60.0925	-68.1634	48	4	0	2966	0	12	10
L-A	0.0	0.0	-0.9873	-0.9873	19	0	0	163	0	1	2
L-D	0.0	0.0	-0.2486	-0.2486	5	0	0	46	0	0	0
A-B	-63.6957	-12.903	-195.384	-271.9827	103	11	1	8504	5	18	13
A-C	-16.277	0.0	-53.1196	-69.3966	32	4	0	1996	0	2	2
A-D	0.0	0.0	-0.0939	-0.0939	6	0	0	28	0	0	0
A-E	0.0	0.0	-0.3211	-0.3211	6	0	0	74	0	0	0
A-J	-18.7559	0.6607	-107.605	-125.7002	74	7	2	5129	0	7	6
A-K	0.0	0.0	-0.1946	-0.1946	5	0	0	36	0	0	0
B-C	-46.6709	-25.8188	256.16	183.6703	194	29	9	19249	2	29	23
B-I	-10.4598	1.8527	-111.978	-120.5851	77	8	2	5986	0	8	9
B-J	0.0	0.9025	-72.0659	-71.1633	46	2	0	3124	0	13	10
C-I	0.0	0.0	-0.1693	-0.1693	5	0	0	36	0	0	0
D-E	-49.3899	-10.8299	-197.058	-257.2778	105	12	2	8284	5	19	17
D-F	-5.3617	0.0	-37.7574	-43.1191	25	3	0	1495	0	2	2
E-F	-26.8313	-36.8056	293.007	229.3702	190	24	9	18825	3	23	21
I-J	-62.9329	-13.9157	-195.639	-272.4875	102	15	2	8411	4	17	16
I-K	-4.3182	0.0	-42.9464	-47.2646	31	6	0	1687	0	2	2
J-K	-47.1076	-42.3459	244.203	154.7495	197	32	8	20137	3	27	25

Interface residues

• G-H: ALA281G, ALA460G, ALA56H, ALA60H, ARG44H, ARG456G, ARG469G, ARG53H, ARG61H, ARG71H, ASN100H, ASN276G, ASN279G, ASN280G, ASN35H, ASN425G, ASN461G, ASN462G, ASN465G, ASN474G, ASN58H, ASN97H, ASP368G, ASP457G, ASP477G, ASP76H, ASP99H, CYS98H, GLN105G, GLN362G, GLN428G, GLN64H, GLU275G, GLU370G, GLU466G, GLU46H, GLY124G, GLY198G, GLY366G, GLY367G, GLY429G, GLY431G, GLY458G, GLY459G, GLY471G, GLY472G, GLY473G, GLY49H, GLY54H, GLY55H, GLY65H, ILE109G, ILE30H, ILE359G, ILE360G, ILE371G, ILE475G, LEU369G, LEU51H, LEU63H, LYS282G, LYS357G, LYS476G, LYS52H, LYS97G, MET426G, MET48H, MET69H, PHE29H, PHE468G, PRO364G, PRO52H, PRO62H, SER199G, SER365G, SER464G, SER75H, THR123G, THR257G, THR278G, THR283G, THR33H, THR358G, THR372G, THR430G, THR455G, THR463G, THR467G, THR68H, THR70H, TRP100H, TRP427G, TRP47H, TRP50H, TYR100H, TYR59H, TYR74H, VAL57H, VAL67H, VAL73H
• G-L: ALA281G, ALA460G, ARG456G, ASN276G, ASN279G, ASN280G, ASN354G, ASN461G, ASN462G, ASP457G, GLN27L, GLN90L, GLU275G, GLU96L, GLY29L, GLY458G, GLY459G, HIS352G, LEU277G, LEU4L, LYS282G, PHE353G, PHE97L, PHE98L, SER30L, THR278G, THR463G, TYR28L, TYR91L, VAL3L
• G-E: ALA204G, ALA433G, ALA436G, ARG105E, ARG327G, ASN204E, ASN425G, ASP325G, ASP440G, CYS119G, CYS205G, GLN10E, GLN422G, GLN432G, GLN6E, GLU16E, GLY104E, GLY106E, GLY124G, GLY198G, GLY431G, GLY8E, GLY9E, ILE110E, ILE201G, ILE326G, ILE420G, ILE423G, ILE424G, ILE439G, LEU122G, LEU369G, LYS121G, LYS12E, LYS13E, LYS201E, LYS202G, LYS207G, LYS419G, LYS421G, MET11E, MET434G, PHE91E, PRO108E, PRO114E, PRO149E, PRO14E, PRO202E, PRO41E, PRO437G, SER112E, SER113E, SER115E, SER199G, SER203E, SER7E, THR107E, THR116E, THR123G, THR430G, THR87E, TYR435G, VAL109E, VAL111E, VAL120G, VAL200G, VAL89E
• G-F: GLN42F, GLY198G, GLY41F, SER199G, VAL200G
• H-L: ALA125H, ALA132L, ALA136H, ALA137H, ALA168H, ALA211H, ALA34L, ALA40H, ALA43L, ALA55L, ALA56L, ALA60H, ARG105H, ARG144L, ARG38H, ARG44H, ARG45L, ARG54L, ARG61H, ARG94H, ASN100H, ASN139L, ASN140L, ASN160L, ASN35H, ASN58H, ASN97H, ASP100H, ASP124L, ASP144H, ASP169L, ASP172L, CYS136L, CYS140H, CYS216H, CYS216L, CYS23L, CYS88L, GLN100L, GLN126L, GLN162L, GLN168L, GLN171H, GLN38L, GLN42L, GLN6H, GLN6L, GLN89L, GLN90L, GLU101H, GLU125L, GLU163L, GLU167L, GLU215L, GLU46H, GLU96L, GLY101L, GLY104H, GLY106H, GLY134H, GLY139H, GLY159L, GLY162H, GLY214L, GLY29L, GLY41L, GLY42H, GLY49H, GLY51L, GLY57L, GLY95H, GLY99L, HIS102H, HIS164H, ILE119L, ILE37H, ILE48L, ILE58L, LEU124H, LEU127L, LEU137L, LEU138H, LEU138L, LEU141H, LEU170H, LEU177L, LEU178H, LEU183L, LEU33L, LEU39H, LEU46L, LEU4L, LYS128L, LYS129H, LYS143H, LYS171L, LYS209H, LYS214H, LYS43H, LYS96H, MET48H, PHE100H, PHE118L, PHE120L, PHE122H, PHE141L, PHE166H, PHE211L, PHE91H, PHE97L, PHE98L, PRO108H, PRO121L, PRO122L, PRO123H, PRO126H, PRO167H, PRO213H, PRO41H, PRO44L, PRO45H, PRO62H, SER116L, SER120H, SER123L, SER127H, SER128H, SER129L, SER133L, SER161H, SER164L, SER172H, SER176L, SER177H, SER178L, SER179H, SER179L, SER180H, SER186H, SER215H, SER30L, SER50L, THR131L, THR135H, THR165H, THR166L, THR174L, THR180L, THR182L, THR183H, THR53L, THR5L, THR93H, TRP100H, TRP103H, TRP35L, TRP36H, TRP47H, TRP50H, TYR100H, TYR175L, TYR188L, TYR36L, TYR49L, TYR86L, TYR87L, TYR91L, VAL117L, VAL121H, VAL134L, VAL135L, VAL163H, VAL165L, VAL169H, VAL181H, VAL182H, VAL184H, VAL207H, VAL3L, VAL47L, VAL85L, VAL89H
• H-A: ARG105H, ARG23H, ASN404A, ASN411A, CYS410A, GLN1H, GLN344A, GLN3H, GLU405A, GLY104H, GLY26H, GLY409A, HIS102H, LEU4H, LYS340A, LYS343A, LYS408A, MET407A, THR336A, THR406A, TRP103H, VAL2H, VAL5H
• H-D: ALA204D, ALA433D, ALA436D, ALA88H, ARG105H, ARG298D, ARG327D, ASN199H, ASN204H, ASN425D, ASP325D, ASP440D, CYS119D, CYS205D, GLN10H, GLN203D, GLN422D, GLN432D, GLN6H, GLU148H, GLU16H, GLY106H, GLY124D, GLY198D, GLY431D, GLY441D, GLY8H, GLY9H, HIS200H, ILE110H, ILE201D, ILE326D, ILE420D, ILE423D, ILE424D, ILE439D, ILE443D, LEU122D, LYS121D, LYS12H, LYS13H, LYS201H, LYS202D, LYS206H, LYS207D, LYS419D, LYS421D, MET11H, MET434D, PHE91H, PRO108H, PRO114H, PRO118D, PRO147H, PRO149H, PRO14H, PRO202H, PRO206D, PRO41H, PRO437D, PRO438D, SER112H, SER113H, SER115H, SER199D, SER203H, SER7H, THR107H, THR116H, THR123D, THR151H, THR205H, THR430D, THR87H, TYR435D, VAL109H, VAL111H, VAL120D, VAL200D, VAL89H
• H-E: ALA24E, ALA24H, ARG105E, ARG105H, ARG19E, ARG19H, ARG23E, ARG23H, ASP72E, ASP72H, ASP76E, ASP76H, CYS22E, CYS22H, GLN10E, GLN10H, GLN6E, GLN6H, GLY106E, GLY106H, GLY8E, GLY8H, GLY9E, GLY9H, ILE20E, ILE20H, PHE79E, PHE79H, SER21E, SER21H, SER25E, SER25H, SER75E, SER75H, SER7E, SER7H, THR107E, THR107H, THR70E, THR70H, THR77E, THR77H, TYR74E, TYR74H, VAL5E, VAL5H, VAL73E, VAL73H
• L-A: ALA43L, ALA56L, ARG39L, ARG45L, ASN404A, ASN462A, ASP60L, GLN42L, GLY397A, GLY57L, ILE58L, LYS350A, LYS408A, MET407A, PRO59L, SER464A, THR358A, THR394A, THR463A
• L-D: GLN42L, GLY198D, GLY41L, SER199D, VAL200D
• A-B: ALA281A, ALA460A, ALA56B, ALA60B, ARG44B, ARG456A, ARG469A, ARG53B, ARG61B, ARG71B, ASN100B, ASN276A, ASN279A, ASN280A, ASN35B, ASN425A, ASN461A, ASN462A, ASN465A, ASN474A, ASN58B, ASN97B, ASP100B, ASP31B, ASP368A, ASP457A, ASP477A, ASP72B, ASP99B, CYS98B, GLN105A, GLN362A, GLN428A, GLN64B, GLU275A, GLU370A, GLU466A, GLU46B, GLY124A, GLY198A, GLY366A, GLY367A, GLY429A, GLY431A, GLY458A, GLY459A, GLY471A, GLY472A, GLY473A, GLY49B, GLY54B, GLY55B, GLY65B, ILE109A, ILE284A, ILE30B, ILE359A, ILE360A, ILE371A, ILE475A, LEU369A, LEU51B, LEU63B, LYS282A, LYS357A, LYS476A, LYS52B, LYS97A, MET426A, MET48B, MET69B, PHE29B, PHE468A, PRO364A, PRO52B, PRO62B, SER199A, SER365A, SER464A, SER75B, THR123A, THR257A, THR278A, THR283A, THR33B, THR358A, THR372A, THR430A, THR455A, THR463A, THR467A, THR68B, THR70B, TRP100B, TRP427A, TRP47B, TRP50B, TYR100B, TYR59B, TYR74B, VAL57B, VAL67B, VAL73B
• A-C: ALA281A, ALA460A, ARG456A, ASN276A, ASN279A, ASN280A, ASN354A, ASN461A, ASN462A, ASP457A, GLN27C, GLN90C, GLU1C, GLU275A, GLU466A, GLU96C, GLY29C, GLY458A, GLY459A, HIS352A, ILE2C, LEU277A, LEU4C, LYS282A, LYS357A, PHE353A, PHE97C, SER30C, THR278A, TYR28C, TYR91C, VAL3C
• A-D: GLY198D, LYS408A, SER199D, SER322A, THR123D, TYR223D
• A-E: ASN334A, GLN1E, LYS337A, LYS408A, THR336A, TYR74E
• A-J: ALA433A, ALA436A, ALA88J, ARG105J, ARG298A, ARG327A, ASN204J, ASN425A, ASP325A, ASP440A, CYS119A, CYS205A, GLN10J, GLN422A, GLN432A, GLN6J, GLU148J, GLU16J, GLY106J, GLY124A, GLY198A, GLY431A, GLY441A, GLY8J, GLY9J, ILE110J, ILE201A, ILE326A, ILE420A, ILE423A, ILE424A, ILE439A, LEU122A, LEU369A, LYS121A, LYS12J, LYS13J, LYS201J, LYS202A, LYS206J, LYS207A, LYS419A, LYS421A, MET11J, MET434A, PHE91J, PRO108J, PRO114J, PRO118A, PRO147J, PRO149J, PRO14J, PRO202J, PRO206A, PRO41J, PRO437A, PRO438A, SER112J, SER113J, SER115J, SER199A, SER203J, SER7J, THR107J, THR116J, THR123A, THR430A, THR87J, TYR435A, VAL109J, VAL111J, VAL120A, VAL200A, VAL89J
• A-K: GLN42K, GLY198A, GLY41K, SER199A, VAL200A
• B-C: ALA125B, ALA132C, ALA136B, ALA137B, ALA168B, ALA211B, ALA34C, ALA40B, ALA43C, ALA55C, ALA56C, ALA60B, ARG105B, ARG144C, ARG38B, ARG44B, ARG45C, ARG54C, ARG61B, ARG94B, ASN100B, ASN139C, ASN140C, ASN160C, ASN212C, ASN35B, ASN58B, ASN97B, ASP100B, ASP124C, ASP144B, ASP169C, ASP172C, CYS136C, CYS140B, CYS216B, CYS216C, CYS23C, CYS88C, CYS92B, GLN100C, GLN126C, GLN162C, GLN171B, GLN38C, GLN42C, GLN6B, GLN6C, GLN89C, GLN90C, GLU101B, GLU125C, GLU163C, GLU167C, GLU1C, GLU215C, GLU46B, GLU96C, GLY101C, GLY104B, GLY106B, GLY130C, GLY139B, GLY159C, GLY162B, GLY214C, GLY29C, GLY41C, GLY42B, GLY49B, GLY51C, GLY57C, GLY95B, GLY99C, HIS102B, HIS164B, ILE119C, ILE2C, ILE37B, ILE48C, ILE58C, LEU124B, LEU127C, LEU137C, LEU138B, LEU138C, LEU141B, LEU170B, LEU175B, LEU177C, LEU178B, LEU181C, LEU183C, LEU33C, LEU39B, LEU46C, LEU4C, LYS128C, LYS129B, LYS143B, LYS209B, LYS209C, LYS210B, LYS214B, LYS43B, LYS96B, MET48B, PHE100B, PHE118C, PHE120C, PHE122B, PHE141C, PHE166B, PHE211C, PHE91B, PHE97C, PHE98C, PRO108B, PRO121C, PRO122C, PRO123B, PRO126B, PRO167B, PRO213B, PRO41B, PRO44C, PRO45B, PRO62B, SER116C, SER120B, SER123C, SER127B, SER128B, SER129C, SER130B, SER133C, SER161C, SER164C, SER172B, SER173B, SER176C, SER177B, SER178C, SER179B, SER179C, SER180B, SER186B, SER210C, SER215B, SER30C, SER50C, THR131C, THR135B, THR165B, THR166C, THR174C, THR180C, THR182C, THR183B, THR208C, THR53C, THR5C, THR93B, TRP100B, TRP103B, TRP35C, TRP36B, TRP47B, TRP50B, TYR100B, TYR175C, TYR176B, TYR28C, TYR36C, TYR49C, TYR86C, TYR87C, TYR91C, VAL117C, VAL121B, VAL134C, VAL135C, VAL163B, VAL165C, VAL169B, VAL181B, VAL182B, VAL184B, VAL207B, VAL207C, VAL3C, VAL47C, VAL85C, VAL89B
• B-I: ALA204I, ALA433I, ALA436I, ALA88B, ARG105B, ARG298I, ARG327I, ASN199B, ASN204B, ASN425I, ASP325I, ASP440I, CYS119I, CYS205I, GLN10B, GLN203I, GLN422I, GLN432I, GLN6B, GLU148B, GLU16B, GLY106B, GLY124I, GLY198I, GLY431I, GLY8B, GLY9B, HIS200B, ILE110B, ILE201I, ILE326I, ILE420I, ILE423I, ILE424I, ILE439I, LEU122I, LEU369I, LYS121I, LYS12B, LYS13B, LYS201B, LYS202I, LYS206B, LYS207I, LYS419I, LYS421I, MET11B, MET434I, PRO108B, PRO114B, PRO118I, PRO147B, PRO149B, PRO14B, PRO202B, PRO206I, PRO41B, PRO437I, PRO438I, SER112B, SER113B, SER115B, SER199I, SER203B, SER7B, THR107B, THR116B, THR123I, THR151B, THR430I, THR87B, TYR435I, VAL109B, VAL111B, VAL120I, VAL200I, VAL89B
• B-J: ALA24B, ALA24J, ARG105B, ARG105J, ARG19B, ARG19J, ARG23B, ARG23J, ASP72B, ASP72J, ASP76B, ASP76J, CYS22B, CYS22J, GLN10B, GLN10J, GLN6B, GLN6J, GLY106B, GLY106J, GLY8B, GLY8J, GLY9B, GLY9J, ILE20B, ILE20J, PHE79B, PHE79J, SER21B, SER21J, SER25B, SER25J, SER75B, SER75J, SER7B, SER7J, THR107B, THR107J, THR77B, THR77J, TYR74B, TYR74J, VAL5B, VAL5J, VAL73B, VAL73J
• C-I: GLN42C, GLY198I, GLY41C, SER199I, VAL200I
• D-E: ALA281D, ALA460D, ALA56E, ALA60E, ARG44E, ARG456D, ARG469D, ARG53E, ARG61E, ARG71E, ASN100E, ASN276D, ASN279D, ASN280D, ASN35E, ASN425D, ASN461D, ASN462D, ASN465D, ASN474D, ASN58E, ASN97E, ASP100E, ASP31E, ASP368D, ASP457D, ASP477D, ASP76E, ASP99E, CYS98E, GLN105D, GLN362D, GLN428D, GLN64E, GLU275D, GLU28E, GLU370D, GLU466D, GLU46E, GLY124D, GLY198D, GLY366D, GLY367D, GLY429D, GLY431D, GLY458D, GLY459D, GLY471D, GLY472D, GLY473D, GLY49E, GLY54E, GLY55E, GLY65E, ILE109D, ILE284D, ILE30E, ILE359D, ILE360D, ILE371D, ILE475D, LEU369D, LEU51E, LEU63E, LYS282D, LYS357D, LYS476D, LYS52E, LYS97D, MET426D, MET48E, MET69E, PHE29E, PHE468D, PRO364D, PRO470D, PRO52E, PRO62E, SER199D, SER365D, SER464D, SER75E, THR123D, THR257D, THR278D, THR283D, THR33E, THR358D, THR372D, THR430D, THR455D, THR463D, THR467D, THR68E, THR70E, TRP100E, TRP427D, TRP47E, TRP50E, TYR100E, TYR59E, TYR74E, VAL57E, VAL67E, VAL73E
• D-F: ALA281D, ALA460D, ARG456D, ASN276D, ASN279D, ASN280D, ASN461D, ASN462D, ASP457D, GLN27F, GLN90F, GLU96F, GLY29F, GLY458D, GLY459D, LEU277D, LEU4F, LYS282D, LYS357D, PHE97F, SER30F, THR278D, TYR28F, TYR91F, VAL3F
• E-F: ALA125E, ALA132F, ALA136E, ALA137E, ALA168E, ALA211E, ALA34F, ALA40E, ALA43F, ALA55F, ALA56F, ALA60E, ARG105E, ARG213F, ARG38E, ARG44E, ARG45F, ARG54F, ARG61E, ARG94E, ASN100E, ASN139F, ASN140F, ASN160F, ASN212F, ASN35E, ASN58E, ASN97E, ASP100E, ASP124F, ASP144E, ASP169F, ASP172F, CYS136F, CYS140E, CYS216E, CYS216F, CYS23F, CYS88F, GLN100F, GLN126F, GLN162F, GLN168F, GLN171E, GLN38F, GLN42F, GLN6E, GLN6F, GLN89F, GLN90F, GLU101E, GLU125F, GLU163F, GLU167F, GLU215F, GLU46E, GLU96F, GLY101F, GLY104E, GLY106E, GLY130F, GLY134E, GLY139E, GLY162E, GLY214F, GLY29F, GLY41F, GLY42E, GLY49E, GLY51F, GLY57F, GLY95E, GLY99F, HIS102E, HIS164E, ILE119F, ILE37E, ILE48F, ILE58F, LEU124E, LEU127F, LEU137F, LEU138E, LEU138F, LEU141E, LEU170E, LEU175E, LEU177F, LEU178E, LEU181F, LEU183F, LEU33F, LEU39E, LEU46F, LEU4F, LYS128F, LYS129E, LYS143E, LYS209E, LYS209F, LYS210E, LYS214E, LYS43E, LYS96E, MET48E, PHE100E, PHE118F, PHE120F, PHE122E, PHE141F, PHE166E, PHE211F, PHE91E, PHE97F, PHE98F, PRO108E, PRO121F, PRO122F, PRO123E, PRO126E, PRO167E, PRO213E, PRO41E, PRO44F, PRO45E, PRO62E, SER116F, SER120E, SER123F, SER127E, SER128E, SER129F, SER130E, SER133F, SER161F, SER164F, SER172E, SER173E, SER176F, SER177E, SER178F, SER179E, SER179F, SER180E, SER186E, SER210F, SER215E, SER30F, SER50F, THR131E, THR131F, THR135E, THR165E, THR166F, THR174F, THR180F, THR182F, THR183E, THR53F, THR5F, THR93E, TRP100E, TRP103E, TRP35F, TRP36E, TRP47E, TRP50E, TYR100E, TYR175F, TYR188F, TYR36F, TYR49F, TYR86F, TYR87F, TYR91F, VAL117F, VAL121E, VAL134F, VAL135F, VAL163E, VAL165F, VAL169E, VAL181E, VAL182E, VAL184E, VAL207E, VAL3F, VAL47F, VAL85F, VAL89E
• I-J: ALA281I, ALA460I, ALA56J, ALA60J, ARG456I, ARG469I, ARG53J, ARG61J, ARG71J, ASN100J, ASN276I, ASN279I, ASN280I, ASN35J, ASN425I, ASN461I, ASN462I, ASN465I, ASN474I, ASN58J, ASN97J, ASP100J, ASP31J, ASP368I, ASP457I, ASP477I, ASP72J, ASP99J, CYS98J, GLN105I, GLN362I, GLN428I, GLN64J, GLU275I, GLU28J, GLU370I, GLU466I, GLU46J, GLY124I, GLY198I, GLY366I, GLY367I, GLY429I, GLY431I, GLY458I, GLY459I, GLY471I, GLY472I, GLY473I, GLY49J, GLY54J, GLY55J, GLY65J, ILE109I, ILE30J, ILE359I, ILE360I, ILE371I, ILE475I, LEU369I, LEU51J, LEU63J, LYS282I, LYS357I, LYS476I, LYS52J, LYS97I, MET426I, MET48J, MET69J, PHE29J, PHE468I, PRO364I, PRO52J, PRO62J, SER199I, SER365I, SER464I, SER75J, THR123I, THR257I, THR278I, THR283I, THR33J, THR358I, THR372I, THR430I, THR455I, THR463I, THR467I, THR68J, THR70J, TRP100J, TRP427I, TRP47J, TRP50J, TYR100J, TYR59J, TYR74J, VAL57J, VAL67J, VAL73J
• I-K: ALA281I, ALA460I, ARG456I, ASN276I, ASN279I, ASN280I, ASN354I, ASN461I, ASN462I, ASP457I, GLN27K, GLN90K, GLU1K, GLU96K, GLY29K, GLY458I, GLY459I, HIS352I, ILE2K, LEU277I, LEU4K, LYS282I, LYS357I, PHE353I, PHE97K, SER30K, THR278I, THR463I, TYR28K, TYR91K, VAL3K
• J-K: ALA125J, ALA132K, ALA136J, ALA137J, ALA168J, ALA211J, ALA34K, ALA40J, ALA43K, ALA55K, ALA56K, ALA60J, ARG105J, ARG144K, ARG213K, ARG38J, ARG44J, ARG45K, ARG54K, ARG61J, ARG94J, ASN100J, ASN139K, ASN140K, ASN160K, ASN212K, ASN35J, ASN58J, ASN97J, ASP100J, ASP124K, ASP144J, ASP169K, ASP172K, CYS136K, CYS140J, CYS216J, CYS216K, CYS23K, CYS88K, CYS92J, GLN100K, GLN126K, GLN162K, GLN171J, GLN37K, GLN38K, GLN42K, GLN6J, GLN6K, GLN89K, GLN90K, GLU101J, GLU125K, GLU163K, GLU167K, GLU1K, GLU215K, GLU46J, GLU96K, GLY101K, GLY104J, GLY106J, GLY130K, GLY133J, GLY139J, GLY159K, GLY162J, GLY214K, GLY29K, GLY41K, GLY42J, GLY49J, GLY51K, GLY95J, GLY99K, HIS102J, HIS164J, ILE119K, ILE2K, ILE37J, ILE48K, ILE58K, LEU124J, LEU127K, LEU137K, LEU138J, LEU138K, LEU141J, LEU170J, LEU177K, LEU178J, LEU181K, LEU183K, LEU33K, LEU39J, LEU46K, LEU4K, LYS128K, LYS129J, LYS143J, LYS171K, LYS209J, LYS209K, LYS210J, LYS214J, LYS43J, LYS96J, MET48J, PHE100J, PHE118K, PHE120K, PHE122J, PHE141K, PHE166J, PHE211K, PHE91J, PHE97K, PHE98K, PRO108J, PRO115K, PRO121K, PRO122K, PRO123J, PRO126J, PRO167J, PRO41J, PRO44K, PRO45J, PRO62J, SER116K, SER120J, SER123K, SER127J, SER128J, SER129K, SER130J, SER132J, SER133K, SER161J, SER161K, SER164K, SER172J, SER173J, SER176K, SER177J, SER178K, SER179J, SER179K, SER180J, SER210K, SER215J, SER30K, SER50K, THR131J, THR131K, THR135J, THR160J, THR165J, THR166K, THR174K, THR180K, THR182K, THR183J, THR208K, THR53K, THR5K, THR93J, TRP100J, TRP103J, TRP35K, TRP36J, TRP47J, TRP50J, TYR100J, TYR175K, TYR194K, TYR36K, TYR49K, TYR86K, TYR87K, TYR91K, VAL117K, VAL121J, VAL134K, VAL135K, VAL163J, VAL165K, VAL169J, VAL181J, VAL182J, VAL184J, VAL193K, VAL3K, VAL47K, VAL85K, VAL89J