3NFF

crystal structure of extended dimerization module of rna polymerase i subcomplex a49/a34.5

• Total interactions analyzed: 28
• Total true interactions: 26
• Strongest Interaction:
  • Chains: C-G
  • Int. Res.: 165
  • Norm. En. per Res.: -6.4237
• Hub Node: A(7)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-75.4379	-52.2733	-339.068	-466.7793	116	14	8	13457	3	31	20
A-D	0.0	0.0	-0.2527	-0.2527	4	0	0	60	0	0	1
A-C	0.0	-3.2153	-19.7191	-22.9344	15	0	0	1015	0	9	4
A-F	0.0	0.0	-0.0203	-0.0203	2	0	0	5	0	1	3
A-E	-216.4133	-30.0857	-806.242	-1052.741	164	37	43	30758	1	65	51
A-H	-62.1025	-20.994	-415.082	-498.1785	104	21	18	16102	0	24	25
A-G	0.0	0.0	-0.5895	-0.5895	4	0	0	28	0	2	4
B-D	0.0	0.0	-0.4725	-0.4725	13	0	0	103	0	3	3
B-C	0.0	0.0	-0.1915	-0.1915	5	0	0	57	0	0	1
B-E	-86.6017	-28.9682	-417.283	-532.8529	109	16	19	16027	0	24	20
B-H	-9.5804	-4.754	-13.9625	-28.2969	26	3	0	720	1	5	3
B-G	0.0	0.0	-0.0615	-0.0615	4	0	0	13	0	1	3
D-C	-60.5503	-25.2541	-317.517	-403.3214	112	19	7	13262	2	29	20
D-F	-15.0008	-23.6387	-17.6939	-56.3334	27	2	0	769	4	6	4
D-E	0.0	0.0	-0.1626	-0.1626	2	0	0	22	0	1	2
D-G	-84.5354	-19.8171	-438.905	-543.2575	104	19	18	16281	2	24	23
C-F	-76.3437	-24.5487	-356.445	-457.3374	103	14	18	14918	0	24	19
C-E	0.0	0.0	-0.3418	-0.3418	4	0	0	20	0	1	2
C-H	0.0	0.0	-0.0017	-0.0017	2	0	0	1	0	0	2
C-G	-231.8745	-44.7961	-783.246	-1059.9166	165	41	41	30041	1	62	51
F-E	0.0	0.0	-0.3413	-0.3413	4	0	0	60	0	0	1
F-H	0.0	0.0	-13.8579	-13.8579	25	1	1	761	0	3	4
F-G	-86.535	-34.9749	-338.938	-460.4479	116	22	5	13000	4	30	19
E-H	-96.196	-45.4034	-379.896	-521.4954	118	25	9	13959	4	30	21
E-G	0.0	1.28	-13.7225	-12.4425	17	0	0	831	0	10	4
H-G	0.0	0.0	-1.0121	-1.0121	8	0	0	129	0	0	1

Interface residues

• A-B: ALA59B, ALA88A, ARG132B, ARG41A, ARG87A, ASN103B, ASN49B, ASN60B, ASN69A, ASN84A, ASN92B, ASP131B, ASP30B, ASP44A, ASP48B, ASP58A, ASP62B, ASP77A, CYS34B, GLN26B, GLN33B, GLN43A, GLN45A, GLN65B, GLN70A, GLN79A, GLU138B, GLU14A, GLU44B, GLU51A, GLU51B, GLU56A, GLU60A, GLU63A, GLY50A, GLY59A, GLY74A, GLY81A, HIS49A, ILE108B, ILE136B, ILE61B, ILE63B, ILE83A, LEU104B, LEU106B, LEU107B, LEU117B, LEU37B, LEU45B, LEU48A, LEU52B, LEU54B, LEU66B, LEU69B, LEU71B, LEU75A, LEU85A, LYS32B, LYS38B, LYS42A, LYS46B, LYS50B, LYS56B, LYS67A, LYS67B, LYS78A, LYS82A, LYS98A, MET55B, MET72A, PHE130B, PHE134B, PHE40B, PHE46A, PHE87B, PRO27B, PRO28B, PRO41B, PRO58B, PRO70B, PRO89A, SER105B, SER137B, SER29B, SER39B, SER43B, SER64B, SER68B, SER80A, SER93A, THR116B, THR135B, THR61A, THR65A, THR66A, THR68A, THR73B, THR92A, TRP53B, TYR12A, TYR25B, TYR31B, TYR57A, TYR71A, TYR76A, TYR86A, VAL119B, VAL128B, VAL133B, VAL42B, VAL47A, VAL57B, VAL73A, VAL90A, VAL91A
• A-D: ALA59D, ASN60D, LEU64A, PRO58D
• A-C: ASN69A, ASN69C, GLU63A, GLU63C, LEU64A, LEU64C, LYS40C, LYS67A, LYS67C, THR65A, THR65C, THR66A, THR66C, THR68A, THR68C
• A-F: ASP30F, LEU64A
• A-E: ALA88A, ALA88E, ALA8A, ALA8E, ARG28A, ARG28E, ARG41A, ARG41E, ARG54A, ARG54E, ARG87A, ARG87E, ASN22A, ASN22E, ASN52A, ASN52E, ASN84A, ASN84E, ASP10A, ASP10E, ASP15A, ASP15E, ASP32A, ASP32E, ASP44A, ASP44E, ASP58A, ASP58E, ASP77A, ASP77E, GLN13A, GLN13E, GLN36A, GLN36E, GLN43A, GLN43E, GLN45A, GLN45E, GLN70A, GLN70E, GLU14A, GLU14E, GLU34A, GLU34E, GLU51A, GLU51E, GLU53A, GLU53E, GLU56A, GLU56E, GLU60A, GLU60E, GLU63A, GLU63E, GLY26A, GLY26E, GLY50A, GLY50E, GLY59A, GLY59E, GLY74A, GLY74E, GLY81A, GLY81E, HIS49A, HIS49E, ILE7A, ILE7E, ILE83A, ILE83E, ILE95A, ILE95E, ILE9A, ILE9E, LEU37A, LEU37E, LEU48A, LEU48E, LEU55A, LEU55E, LEU75A, LEU75E, LEU85A, LEU85E, LYS31A, LYS31E, LYS39A, LYS39E, LYS40A, LYS40E, LYS42A, LYS42E, LYS67A, LYS67E, LYS78A, LYS78E, LYS82A, LYS82E, LYS94A, LYS94E, MET72A, MET72E, PHE23A, PHE23E, PHE24A, PHE24E, PHE35A, PHE35E, PHE46A, PHE46E, PRO16A, PRO16E, PRO30A, PRO30E, PRO89A, PRO89E, SER11A, SER11E, SER17A, SER17E, SER21A, SER21E, SER6A, SER6E, SER80A, SER80E, SER93A, SER93E, THR33A, THR33E, THR61A, THR61E, THR92A, THR92E, TYR12A, TYR12E, TYR38A, TYR38E, TYR57A, TYR57E, TYR71A, TYR71E, TYR76A, TYR76E, TYR86A, TYR86E, VAL18A, VAL18E, VAL19A, VAL19E, VAL20A, VAL20E, VAL27A, VAL27E, VAL29A, VAL29E, VAL47A, VAL47E, VAL73A, VAL73E, VAL90A, VAL90E, VAL91A, VAL91E
• A-H: ALA120H, ALA8A, ARG132H, ARG28A, ARG41A, ASN101H, ASN103H, ASN22A, ASP100H, ASP10A, ASP15A, ASP30H, ASP32A, ASP62H, ASP72H, CYS34H, GLN13A, GLN26H, GLN33H, GLN36A, GLN65H, GLU115H, GLU14A, GLU34A, GLU44H, GLU97H, GLY26A, GLY98H, HIS36H, ILE108H, ILE61H, ILE63H, ILE7A, ILE9A, LEU104H, LEU106H, LEU107H, LEU117H, LEU37A, LEU37H, LEU52H, LEU54H, LEU66H, LEU69H, LEU71H, LEU82H, LYS113H, LYS114H, LYS118H, LYS123H, LYS25A, LYS31A, LYS32H, LYS35H, LYS38H, LYS39A, LYS40A, LYS42A, LYS67H, MET55H, PHE130H, PHE134H, PHE23A, PHE24A, PHE35A, PHE40H, PRO109H, PRO16A, PRO27H, PRO28H, PRO30A, PRO41H, PRO70H, SER105H, SER110H, SER11A, SER127H, SER17A, SER21A, SER29H, SER39H, SER64H, SER68H, SER6A, SER99H, THR102H, THR116H, THR121H, THR33A, THR73H, TRP53H, TYR129H, TYR12A, TYR25H, TYR31H, TYR38A, VAL119H, VAL133H, VAL18A, VAL19A, VAL20A, VAL27A, VAL29A, VAL42H
• A-G: GLU63A, GLU63G, LYS67A, LYS67G
• B-D: ASN88B, ASN88D, GLU138B, GLU138D, GLU97B, GLU97D, LEU90B, LEU90D, LYS56B, LYS56D, THR135B, THR139B, THR139D
• B-C: ALA59B, ASN60B, LEU64C, LYS56B, THR68C
• B-E: ALA120B, ALA8E, ARG132B, ARG28E, ARG41E, ARG87E, ASN101B, ASN103B, ASN22E, ASP100B, ASP10E, ASP15E, ASP30B, ASP32E, ASP62B, ASP72B, CYS34B, GLN13E, GLN26B, GLN33B, GLN36E, GLN43E, GLN65B, GLN96B, GLU115B, GLU14E, GLU34E, GLU97B, GLY26E, GLY98B, HIS36B, ILE108B, ILE61B, ILE63B, ILE7E, ILE9E, LEU104B, LEU106B, LEU107B, LEU117B, LEU37B, LEU37E, LEU45B, LEU52B, LEU54B, LEU66B, LEU69B, LEU71B, LEU82B, LYS113B, LYS118B, LYS123B, LYS25E, LYS31E, LYS32B, LYS35B, LYS38B, LYS39E, LYS40E, LYS42E, LYS67B, LYS67E, MET55B, PHE130B, PHE134B, PHE23E, PHE24E, PHE35E, PHE40B, PRO109B, PRO16E, PRO27B, PRO28B, PRO30E, PRO41B, PRO70B, SER105B, SER110B, SER11E, SER127B, SER17E, SER21E, SER29B, SER39B, SER64B, SER68B, SER6E, SER99B, THR102B, THR116B, THR121B, THR33E, THR73B, THR95B, TRP53B, TYR129B, TYR12E, TYR25B, TYR31B, TYR38E, VAL119B, VAL133B, VAL18E, VAL19E, VAL20E, VAL27E, VAL29E, VAL42B, VAL80B
• B-H: ALA59B, ALA59H, ASN60B, ASN60H, ASP30B, ASP30H, ASP62B, ASP62H, GLN26B, GLN33B, GLN33H, GLN65B, GLN65H, ILE61B, ILE61H, ILE63H, LYS32B, LYS32H, LYS35B, LYS85B, SER29B, SER29H, SER64B, SER64H, TYR31B, TYR31H
• B-G: ASP30B, ASP62G, LEU64G, SER29B
• D-C: ALA59D, ALA88C, ARG132D, ARG41C, ARG87C, ASN103D, ASN49D, ASN60D, ASN69C, ASN84C, ASP131D, ASP44C, ASP48D, ASP58C, ASP62D, ASP77C, CYS34D, GLN26D, GLN43C, GLN45C, GLN65D, GLN70C, GLN79C, GLU138D, GLU14C, GLU44D, GLU51C, GLU51D, GLU56C, GLU60C, GLU63C, GLY50C, GLY59C, GLY74C, GLY81C, HIS49C, ILE108D, ILE136D, ILE61D, ILE63D, ILE83C, LEU104D, LEU106D, LEU107D, LEU117D, LEU37D, LEU45D, LEU48C, LEU52D, LEU54D, LEU66D, LEU69D, LEU71D, LEU75C, LEU85C, LYS118D, LYS32D, LYS38D, LYS42C, LYS46D, LYS50D, LYS56D, LYS67C, LYS67D, LYS78C, LYS82C, LYS98C, MET55D, MET72C, PHE130D, PHE134D, PHE40D, PHE46C, PRO27D, PRO28D, PRO41D, PRO58D, PRO70D, PRO89C, SER105D, SER137D, SER39D, SER43D, SER64D, SER68D, SER80C, SER93C, THR116D, THR135D, THR61C, THR65C, THR66C, THR68C, THR73D, THR92C, TRP53D, TYR12C, TYR25D, TYR31D, TYR57C, TYR71C, TYR76C, TYR86C, VAL119D, VAL128D, VAL133D, VAL42D, VAL47C, VAL57D, VAL73C, VAL90C, VAL91C
• D-F: ALA59D, ALA59F, ASN60D, ASN60F, ASP30D, ASP30F, ASP62D, ASP62F, GLN33D, GLN33F, GLN65D, GLN65F, ILE61D, ILE61F, ILE63D, ILE63F, LEU66F, LYS32D, LYS32F, LYS35D, LYS35F, LYS85D, SER29D, SER29F, SER64D, SER64F, TYR31D
• D-E: ASP30D, LEU64E
• D-G: ALA120D, ALA8G, ARG28G, ARG41G, ARG87G, ASN101D, ASN103D, ASN22G, ASP100D, ASP10G, ASP15G, ASP30D, ASP32G, ASP62D, ASP72D, CYS34D, GLN13G, GLN26D, GLN33D, GLN36G, GLN65D, GLN96D, GLU115D, GLU14G, GLU34G, GLU97D, GLY26G, GLY98D, HIS36D, ILE108D, ILE61D, ILE63D, ILE7G, ILE9G, LEU104D, LEU106D, LEU107D, LEU117D, LEU37D, LEU37G, LEU45D, LEU52D, LEU54D, LEU66D, LEU69D, LEU71D, LEU82D, LYS113D, LYS114D, LYS118D, LYS25G, LYS31G, LYS32D, LYS35D, LYS38D, LYS39G, LYS40G, LYS42G, LYS67D, LYS67G, MET55D, PHE130D, PHE23G, PHE24G, PHE35G, PHE40D, PRO109D, PRO16G, PRO27D, PRO28D, PRO30G, PRO41D, PRO70D, SER105D, SER110D, SER11G, SER127D, SER17G, SER21G, SER29D, SER39D, SER64D, SER68D, SER6G, SER99D, THR102D, THR116D, THR121D, THR33G, THR73D, TRP53D, TYR129D, TYR12G, TYR25D, TYR31D, TYR38G, VAL119D, VAL18G, VAL19G, VAL20G, VAL27G, VAL29G, VAL42D, VAL80D
• C-F: ALA8C, ARG28C, ARG41C, ARG87C, ASN101F, ASN103F, ASN22C, ASP100F, ASP10C, ASP15C, ASP30F, ASP32C, ASP62F, ASP72F, CYS34F, GLN13C, GLN26F, GLN33F, GLN36C, GLN65F, GLN96F, GLU115F, GLU14C, GLU34C, GLU97F, GLY26C, GLY98F, HIS36F, ILE108F, ILE61F, ILE63F, ILE7C, ILE9C, LEU104F, LEU106F, LEU107F, LEU117F, LEU37C, LEU37F, LEU45F, LEU52F, LEU54F, LEU66F, LEU69F, LEU71F, LEU82F, LYS113F, LYS114F, LYS118F, LYS25C, LYS31C, LYS32F, LYS35F, LYS38F, LYS39C, LYS40C, LYS42C, LYS67C, LYS67F, MET55F, PHE130F, PHE134F, PHE23C, PHE24C, PHE35C, PHE40F, PRO109F, PRO16C, PRO27F, PRO28F, PRO30C, PRO41F, PRO70F, SER105F, SER127F, SER17C, SER21C, SER29F, SER39F, SER64F, SER68F, SER6C, SER99F, THR102F, THR116F, THR121F, THR33C, THR73F, TRP53F, TYR129F, TYR12C, TYR25F, TYR31F, TYR38C, VAL119F, VAL18C, VAL19C, VAL20C, VAL27C, VAL29C, VAL42F, VAL57F, VAL80F
• C-E: GLU63C, GLU63E, LYS67C, LYS67E
• C-H: ASP30H, LEU64C
• C-G: ALA88C, ALA88G, ALA8C, ALA8G, ARG28C, ARG28G, ARG41C, ARG41G, ARG54C, ARG54G, ARG87C, ARG87G, ASN22C, ASN22G, ASN52C, ASN52G, ASN84C, ASN84G, ASP10C, ASP10G, ASP15C, ASP15G, ASP32C, ASP32G, ASP44C, ASP44G, ASP58C, ASP58G, ASP77C, ASP77G, GLN13C, GLN13G, GLN36C, GLN36G, GLN43C, GLN43G, GLN45C, GLN45G, GLN70C, GLN70G, GLU14C, GLU14G, GLU34C, GLU34G, GLU51C, GLU51G, GLU53C, GLU53G, GLU56C, GLU56G, GLU60C, GLU60G, GLU63C, GLU63G, GLY26C, GLY50C, GLY50G, GLY59C, GLY59G, GLY74C, GLY74G, GLY81C, GLY81G, HIS49C, HIS49G, ILE7C, ILE7G, ILE83C, ILE83G, ILE95C, ILE95G, ILE9C, ILE9G, LEU37C, LEU37G, LEU48C, LEU48G, LEU55C, LEU55G, LEU75C, LEU75G, LEU85C, LEU85G, LYS31C, LYS31G, LYS39C, LYS39G, LYS40C, LYS40G, LYS42C, LYS42G, LYS67C, LYS67G, LYS78C, LYS78G, LYS82C, LYS82G, LYS94C, LYS94G, MET72C, MET72G, PHE23C, PHE23G, PHE24C, PHE24G, PHE35C, PHE35G, PHE46C, PHE46G, PRO16C, PRO16G, PRO30C, PRO30G, PRO89C, PRO89G, SER11C, SER11G, SER17C, SER17G, SER21C, SER21G, SER6C, SER6G, SER80C, SER80G, SER93C, SER93G, THR33C, THR33G, THR61C, THR61G, THR92C, THR92G, TYR12C, TYR12G, TYR38C, TYR38G, TYR57C, TYR57G, TYR71C, TYR71G, TYR76C, TYR76G, TYR86C, TYR86G, VAL18C, VAL18G, VAL19C, VAL19G, VAL20C, VAL20G, VAL27C, VAL27G, VAL29C, VAL29G, VAL47C, VAL47G, VAL73C, VAL73G, VAL90C, VAL90G, VAL91C, VAL91G, VAL96C, VAL96G
• F-E: ALA59F, ASN60F, LEU64E, PRO58F
• F-H: ALA140H, ASN86H, ASN88F, ASN88H, ASN92F, GLN91F, GLU138F, GLU138H, GLU97F, GLU97H, GLY98F, ILE136F, LEU90F, LEU90H, LYS56F, LYS56H, SER137F, SER137H, THR135F, THR135H, THR139F, THR139H, THR95F, VAL77H, VAL89F
• F-G: ALA59F, ALA88G, ARG132F, ARG41G, ARG87G, ASN103F, ASN49F, ASN60F, ASN69G, ASN84G, ASN92F, ASP131F, ASP30F, ASP44G, ASP48F, ASP58G, ASP62F, ASP62G, ASP77G, CYS34F, GLN26F, GLN33F, GLN43G, GLN45G, GLN65F, GLN70G, GLN79G, GLU138F, GLU14G, GLU44F, GLU51F, GLU51G, GLU56G, GLU60G, GLU63G, GLY50G, GLY59G, GLY74G, GLY81G, HIS49G, ILE108F, ILE136F, ILE61F, ILE63F, ILE83G, LEU104F, LEU106F, LEU107F, LEU117F, LEU37F, LEU45F, LEU48G, LEU52F, LEU54F, LEU66F, LEU69F, LEU71F, LEU75G, LEU82F, LEU85G, LYS32F, LYS38F, LYS42G, LYS46F, LYS50F, LYS56F, LYS67F, LYS67G, LYS78G, LYS82G, LYS98G, MET55F, MET72G, PHE130F, PHE134F, PHE40F, PHE46G, PHE87F, PRO109F, PRO27F, PRO28F, PRO41F, PRO58F, PRO89G, SER105F, SER137F, SER39F, SER43F, SER64F, SER68F, SER80G, SER93G, THR116F, THR135F, THR61G, THR65G, THR66G, THR68G, THR73F, THR92G, TRP53F, TYR12G, TYR25F, TYR31F, TYR57G, TYR71G, TYR76G, TYR86G, VAL128F, VAL133F, VAL42F, VAL47G, VAL57F, VAL73G, VAL90G, VAL91G
• E-H: ALA120H, ALA59H, ALA88E, ARG132H, ARG41E, ARG87E, ASN103H, ASN49H, ASN52E, ASN60H, ASN69E, ASN84E, ASN92H, ASP131H, ASP44E, ASP48H, ASP58E, ASP62H, ASP77E, CYS34H, GLN26H, GLN33H, GLN43E, GLN45E, GLN65H, GLN70E, GLN79E, GLU115H, GLU138H, GLU14E, GLU44H, GLU51E, GLU51H, GLU56E, GLU60E, GLU63E, GLY47H, GLY50E, GLY59E, GLY74E, GLY81E, HIS49E, ILE108H, ILE136H, ILE61H, ILE63H, ILE83E, LEU104H, LEU106H, LEU107H, LEU117H, LEU37H, LEU45H, LEU48E, LEU52H, LEU54H, LEU64E, LEU66H, LEU69H, LEU71H, LEU75E, LEU85E, LYS118H, LYS32H, LYS38H, LYS42E, LYS46H, LYS50H, LYS56H, LYS67E, LYS67H, LYS78E, LYS82E, LYS85H, LYS98E, MET55H, MET72E, PHE130H, PHE134H, PHE40H, PHE46E, PRO27H, PRO28H, PRO41H, PRO58H, PRO70H, PRO89E, SER105H, SER137H, SER39H, SER43H, SER64H, SER68H, SER80E, SER93E, THR135H, THR61E, THR65E, THR66E, THR68E, THR73H, THR92E, TRP53H, TYR25H, TYR31H, TYR57E, TYR71E, TYR76E, TYR86E, VAL119H, VAL128H, VAL133H, VAL42H, VAL47E, VAL57H, VAL73E, VAL90E, VAL91E
• E-G: ASN69E, ASN69G, GLU63E, GLU63G, LEU64E, LEU64G, LYS40E, LYS40G, LYS42E, LYS67E, LYS67G, THR65E, THR65G, THR66E, THR66G, THR68E, THR68G
• H-G: ALA140H, ALA59H, ASN60H, ASN69G, ASP62G, LEU64G, PRO58H, TYR71G