3N99

crystal structure of tm1086

• Total interactions analyzed: 435
• Total true interactions: 66
• Strongest Interaction:
  • Chains: J-K
  • Int. Res.: 117
  • Norm. En. per Res.: -3.8395
• Hub Node: A(9)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-53.4445	-24.3032	-329.119	-406.8667	119	12	12	14436	2	30	26
A-D	-65.2993	-24.4859	-329.87	-419.6552	119	17	13	14304	2	29	26
A-G	-17.1404	0.0	-42.9946	-60.135	29	3	5	1884	0	2	2
A-J	-28.5669	-2.771	-242.646	-273.9839	103	11	7	9793	0	35	29
A-O	-38.3077	3.6069	-75.0759	-109.7767	36	6	1	2674	1	29	19
B-C	-53.0463	-25.1763	-331.077	-409.2996	119	19	11	14650	2	29	26
B-J	-17.3641	0.0	-40.7919	-58.156	28	3	5	1857	0	2	2
B-K	-34.6273	0.5184	-243.599	-277.7078	102	13	7	9916	0	35	29
C-E	-56.9523	-23.9166	-334.977	-415.8458	116	12	12	14422	2	31	26
C-I	-30.6869	-1.1263	-248.603	-280.4162	105	11	7	10009	0	36	29
C-K	-16.1792	0.0	-40.0815	-56.2607	28	1	5	1835	0	2	2
D-E	-71.9656	-25.4851	-347.628	-445.0787	117	17	11	14652	2	30	26
D-G	-22.3966	0.3062	-246.834	-268.9244	103	14	7	9942	0	34	29
D-H	-17.1346	0.0	-41.3879	-58.5225	28	2	5	1836	0	2	2
D-L	-28.8529	2.412	-76.4165	-102.8574	35	3	1	2729	2	29	19
D-b	-31.5971	12.1332	-78.2517	-97.7156	35	4	1	2663	0	29	19
E-H	-37.3286	0.3603	-249.657	-286.6253	104	11	7	9871	0	36	29
E-I	-16.9428	0.0	-43.1643	-60.1071	28	3	5	1884	0	2	2
E-c	-29.1139	7.6225	-75.5981	-97.0895	38	5	1	2687	0	31	19
G-H	-63.9357	-12.7379	-345.648	-422.3215	117	11	13	14544	2	31	26
G-J	-67.9427	-23.2284	-332.171	-423.3421	117	18	12	14293	2	31	25
H-I	-46.7649	-11.1207	-335.712	-393.5976	116	12	11	14328	0	29	26
I-K	-65.4595	-23.9739	-333.238	-422.6714	118	19	12	14594	2	30	25
J-K	-86.9313	-25.4321	-336.862	-449.2254	117	17	11	14433	2	29	26
L-M	-58.7832	-25.8056	-329.232	-413.8208	115	16	12	14366	2	29	26
L-O	-72.6573	-19.1705	-341.257	-433.0849	117	14	12	14623	2	30	27
L-S	-19.0848	0.0	-39.1248	-58.2096	28	2	5	1846	0	2	2
L-V	-28.2617	-1.894	-250.924	-281.0797	107	15	7	9982	0	35	29
L-b	-31.1788	5.0556	-72.6471	-98.7703	36	5	1	2628	2	28	19
M-N	-72.014	-20.0718	-343.437	-435.5227	118	14	12	14634	2	30	26
M-V	-19.0122	0.0	-39.6471	-58.6593	28	3	5	1849	0	2	2
M-X	-30.7879	0.4231	-230.499	-260.8639	103	15	7	9621	0	34	29
M-a	-35.2126	10.4143	-72.5602	-97.3585	35	3	1	2576	0	30	19
N-P	-69.51	-24.673	-327.899	-422.082	120	18	12	14560	2	30	26
N-U	-28.764	0.5938	-244.026	-272.1962	104	14	7	9712	0	36	29
N-X	-18.0365	0.0	-42.3731	-60.4096	29	2	5	1897	0	2	2
O-P	-72.0247	-23.8585	-328.924	-424.8072	117	18	13	14517	2	30	26
O-S	-28.498	0.512	-238.495	-266.481	102	10	7	9672	0	32	29
O-T	-18.6244	0.0	-41.2298	-59.8542	30	2	5	1920	0	2	2
P-T	-33.3976	4.4876	-250.221	-279.131	104	12	7	9991	0	36	29
P-U	-18.6978	0.0	-39.8796	-58.5774	29	2	5	1882	0	2	2
S-T	-57.6457	-14.6678	-330.614	-402.9275	116	11	11	14258	1	29	26
S-V	-69.8366	-23.3803	-333.702	-426.9189	115	12	13	14480	2	30	26
T-U	-52.3286	-21.1883	-325.005	-398.5219	118	17	11	14238	2	30	25
U-X	-57.9059	-22.2885	-333.747	-413.9414	116	18	11	14388	2	30	26
V-X	-63.5004	-23.9528	-328.72	-416.1733	116	12	12	14343	2	29	26
a-b	-51.4748	-25.5577	-324.824	-401.8565	119	18	11	14475	2	29	26
a-d	-69.1482	-23.8584	-292.548	-385.5546	106	15	10	13144	2	30	26
a-g	-17.5171	0.0			4
a-j	-33.3736	0.2908			14
b-c	-49.0488	-23.3062	-327.597	-399.9521	118	17	13	14473	2	30	26
b-j	-19.2028	0.0			4
b-k	-28.6942	-2.274			16
c-e	-58.6191	-19.2453			13
c-i	-32.3691	0.3543			14
c-k	-19.3203	0.0			4
d-e	-79.0549	-26.2472			14
d-g	-39.4066	4.6549			18
d-h	-16.9226	0.0			4
e-h	-28.7135	0.4907			14
e-i	-17.1915	0.0			4
g-h	-52.7943	-13.7659			17
g-j	-72.5142	-24.0242			15
h-i	-62.3936	-22.7526			15
i-k	-60.9878	-17.7787			16
j-k	-87.9887	-20.8667			15

Interface residues

• A-B: ALA134A, ALA188A, ALA18B, ALA192A, ALA20B, ALA57B, ALA95B, ARG10A, ARG23B, ARG35B, ARG70A, ARG70B, ARG71A, ARG7A, ARG99A, ASN151A, ASN202B, ASN224A, ASN46B, ASN4A, ASP128A, ASP128B, ASP59B, ASP6A, ASP94B, CYS83A, GLN137A, GLU16A, GLU16B, GLU62B, GLU73A, GLU74A, GLU75A, GLY122B, GLY127B, GLY136A, GLY138A, GLY15A, GLY227A, GLY41B, GLY42B, GLY55B, GLY58B, GLY64B, GLY93B, GLY97A, HIS60B, ILE11A, ILE130A, ILE132A, ILE17B, ILE37B, ILE43B, ILE76A, ILE89A, LEU121B, LEU124B, LEU131A, LEU139A, LEU40B, LEU78A, LEU81A, LEU8A, LYS105A, LYS123B, LYS129A, LYS129B, LYS133A, LYS140A, LYS148A, LYS21B, LYS5A, LYS96A, MET125B, MET150A, MET22B, MET68B, MET79A, MET91A, PRO19B, PRO25B, PRO38B, PRO63B, PRO77A, SER12A, SER189A, SER190A, SER191A, SER193A, SER225A, SER244B, SER24B, SER27B, SER52B, SER66B, SER92A, SER92B, THR33B, THR44B, THR80A, TRP135A, TRP56B, TYR226A, TYR26B, TYR45B, TYR54B, VAL126B, VAL13A, VAL149A, VAL14A, VAL228A, VAL34B, VAL36B, VAL39B, VAL47B, VAL61B, VAL65B, VAL90A, VAL9A
• A-D: ALA134D, ALA188D, ALA18A, ALA192D, ALA20A, ALA57A, ALA95A, ARG10D, ARG23A, ARG35A, ARG70A, ARG70D, ARG71D, ARG7D, ARG99D, ASN151D, ASN224D, ASN46A, ASN4D, ASP128A, ASP128D, ASP59A, ASP6D, ASP94A, GLN137D, GLU118A, GLU16A, GLU16D, GLU62A, GLU73D, GLU74D, GLU75D, GLY122A, GLY127A, GLY136D, GLY138D, GLY15D, GLY227D, GLY41A, GLY42A, GLY55A, GLY58A, GLY64A, GLY93A, GLY97D, HIS111A, HIS60A, ILE11D, ILE130D, ILE132D, ILE17A, ILE37A, ILE43A, ILE76D, ILE89D, LEU121A, LEU124A, LEU131D, LEU139D, LEU40A, LEU78D, LEU81D, LEU8D, LYS105D, LYS123A, LYS129D, LYS133D, LYS140D, LYS148D, LYS21A, LYS5D, LYS96D, MET125A, MET150D, MET22A, MET68A, MET79D, MET91D, PRO19A, PRO25A, PRO38A, PRO63A, PRO77D, SER12D, SER189D, SER190D, SER191D, SER193D, SER225D, SER244A, SER24A, SER27A, SER52A, SER66A, SER92A, SER92D, THR194D, THR33A, THR44A, THR80D, TRP135D, TRP56A, TYR226D, TYR26A, TYR45A, TYR54A, VAL126A, VAL13D, VAL149D, VAL14D, VAL228D, VAL34A, VAL36A, VAL39A, VAL47A, VAL61A, VAL65A, VAL90D, VAL9D
• A-G: ALA249A, ALA249G, ARG23A, ARG23G, ARG35A, ARG35G, GLU31A, GLU31G, GLY32A, GLY32G, PRO25A, PRO25G, SER248A, SER248G, SER24A, SER24G, SER27A, SER27G, THR29A, THR29G, THR30G, THR33A, THR33G, TYR26A, TYR26G, VAL28A, VAL28G, VAL34A, VAL34G
• A-J: ALA179A, ALA179J, ALA188A, ALA188J, ALA200A, ALA200J, ALA249A, ALA249J, ARG232A, ARG232J, ARG23A, ARG23J, ASN202A, ASN202J, ASN224A, ASN224J, ASP197A, ASP197J, ASP205A, ASP205J, ASP221A, ASP221J, ASP223A, ASP223J, CYS246A, CYS246J, GLN220A, GLN220J, GLU31A, GLU31J, GLY183A, GLY183J, GLY185A, GLY185J, GLY187A, GLY187J, GLY227A, GLY227J, GLY229A, GLY229J, GLY250A, GLY250J, GLY32A, GLY32J, HIS180A, HIS180J, HIS222A, HIS222J, HIS251A, HIS251J, HIS60A, HIS60J, ILE186A, ILE186J, ILE76A, ILE76J, LYS148A, LYS148J, LYS230A, LYS230J, LYS233A, LYS233J, LYS72A, MET181A, MET181J, MET182A, MET182J, MET199A, MET199J, PRO178A, PRO178J, SER184A, SER184J, SER189A, SER189J, SER190A, SER190J, SER191A, SER191J, SER201A, SER201J, SER225A, SER225J, SER248A, SER248J, THR29A, THR29J, THR30A, THR30J, THR33A, THR33J, TYR196A, TYR196J, TYR226A, TYR226J, TYR231A, TYR231J, VAL228A, VAL228J, VAL247A, VAL247J, VAL28A, VAL28J
• A-O: ALA209A, ALA274A, ARG273A, ARG2O, ASN166O, ASP143O, ASP210A, ASP278A, GLN163A, GLN163O, GLU164O, GLU204A, GLU269A, GLU270A, GLU272A, GLY-1O, GLY167O, GLY207A, HIS0O, HIS144O, HIS170A, ILE162O, ILE169O, LEU142O, LEU267A, LYS165A, LYS165O, LYS168O, LYS176A, LYS212A, MET1O, PRO172A, PRO268A, VAL173A, VAL208A, VAL271A
• B-C: ALA134B, ALA188B, ALA18C, ALA192B, ALA20C, ALA57C, ALA95C, ARG10B, ARG23C, ARG35C, ARG70B, ARG70C, ARG71B, ARG7B, ARG99B, ASN151B, ASN224B, ASN46C, ASN4B, ASP128B, ASP128C, ASP59C, ASP6B, ASP94C, CYS83B, GLN137B, GLU118C, GLU16B, GLU16C, GLU62C, GLU73B, GLU74B, GLU75B, GLY122C, GLY127C, GLY136B, GLY138B, GLY15B, GLY227B, GLY41C, GLY42C, GLY55C, GLY58C, GLY64C, GLY93C, GLY97B, HIS60C, ILE11B, ILE130B, ILE132B, ILE17C, ILE37C, ILE43C, ILE76B, ILE89B, LEU121C, LEU124C, LEU131B, LEU139B, LEU40C, LEU78B, LEU81B, LEU8B, LYS105B, LYS123C, LYS129B, LYS133B, LYS140B, LYS148B, LYS21C, LYS5B, LYS96B, MET125C, MET150B, MET22C, MET68C, MET79B, MET91B, PRO19C, PRO25C, PRO38C, PRO63C, PRO77B, SER12B, SER189B, SER190B, SER191B, SER193B, SER225B, SER244C, SER24C, SER27C, SER52C, SER66C, SER92B, SER92C, THR194B, THR33C, THR44C, THR80B, TRP135B, TRP56C, TYR226B, TYR26C, TYR45C, TYR54C, VAL126C, VAL13B, VAL149B, VAL14B, VAL228B, VAL34C, VAL36C, VAL39C, VAL47C, VAL61C, VAL65C, VAL90B, VAL9B
• B-J: ALA249B, ALA249J, ARG35B, ARG35J, GLU31B, GLU31J, GLY32B, GLY32J, PRO25B, PRO25J, SER248B, SER248J, SER24B, SER24J, SER27B, SER27J, THR29B, THR29J, THR30B, THR30J, THR33B, THR33J, TYR26B, TYR26J, VAL28B, VAL28J, VAL34B, VAL34J
• B-K: ALA179B, ALA179K, ALA188B, ALA188K, ALA200B, ALA200K, ALA249B, ALA249K, ARG232B, ARG232K, ARG23B, ARG23K, ASN202B, ASN202K, ASN224B, ASN224K, ASP197B, ASP197K, ASP205B, ASP205K, ASP221B, ASP221K, ASP223B, ASP223K, CYS246B, CYS246K, GLN220B, GLN220K, GLU31B, GLU31K, GLY183B, GLY183K, GLY185B, GLY185K, GLY187B, GLY187K, GLY227B, GLY227K, GLY229B, GLY229K, GLY250B, GLY250K, GLY252B, GLY252K, GLY32B, GLY32K, HIS180B, HIS180K, HIS222B, HIS222K, HIS251B, HIS251K, HIS60B, HIS60K, ILE186B, ILE186K, ILE76K, LYS148B, LYS230B, LYS230K, LYS233B, LYS233K, MET181B, MET181K, MET182B, MET182K, MET199B, MET199K, PRO178B, PRO178K, SER184B, SER184K, SER189B, SER189K, SER190B, SER190K, SER191B, SER191K, SER201B, SER201K, SER225B, SER225K, SER248B, SER248K, THR29B, THR29K, THR30B, THR30K, THR33B, THR33K, TYR196B, TYR196K, TYR226B, TYR226K, TYR231B, TYR231K, VAL228B, VAL228K, VAL247B, VAL247K, VAL28B, VAL28K
• C-E: ALA134C, ALA188C, ALA18E, ALA192C, ALA20E, ALA57E, ALA95E, ARG10C, ARG23E, ARG35E, ARG70C, ARG70E, ARG71C, ARG7C, ARG99C, ASN151C, ASN224C, ASN46E, ASN4C, ASP128C, ASP128E, ASP59E, ASP6C, ASP94E, GLN137C, GLU118E, GLU16C, GLU16E, GLU62E, GLU73C, GLU74C, GLU75C, GLY122E, GLY127E, GLY136C, GLY138C, GLY15C, GLY227C, GLY41E, GLY42E, GLY55E, GLY58E, GLY64E, GLY93E, GLY97C, HIS111E, ILE11C, ILE130C, ILE132C, ILE17E, ILE37E, ILE43E, ILE76C, ILE89C, LEU121E, LEU124E, LEU131C, LEU139C, LEU40E, LEU78C, LEU81C, LEU8C, LYS105C, LYS123E, LYS129C, LYS133C, LYS140C, LYS148C, LYS21E, LYS5C, LYS96C, MET125E, MET150C, MET22E, MET68E, MET79C, MET91C, PRO19E, PRO25E, PRO38E, PRO63E, PRO77C, SER12C, SER189C, SER190C, SER191C, SER193C, SER225C, SER244E, SER24E, SER52E, SER66E, SER92C, SER92E, THR33E, THR44E, THR80C, TRP135C, TRP56E, TYR226C, TYR26E, TYR45E, TYR54E, VAL126E, VAL13C, VAL149C, VAL14C, VAL228C, VAL34E, VAL36E, VAL39E, VAL47E, VAL61E, VAL65E, VAL90C, VAL9C
• C-I: ALA179C, ALA179I, ALA188C, ALA188I, ALA200C, ALA200I, ALA249C, ALA249I, ARG232C, ARG232I, ARG23C, ARG23I, ASN202C, ASN202I, ASN224C, ASN224I, ASP197C, ASP197I, ASP205C, ASP205I, ASP221C, ASP221I, ASP223C, ASP223I, CYS246C, CYS246I, GLN220C, GLN220I, GLU31C, GLU31I, GLY183C, GLY183I, GLY185C, GLY185I, GLY187C, GLY187I, GLY227C, GLY227I, GLY229C, GLY229I, GLY250C, GLY250I, GLY252C, GLY252I, GLY32C, GLY32I, HIS180C, HIS180I, HIS222C, HIS222I, HIS251C, HIS251I, HIS60C, HIS60I, ILE186C, ILE186I, ILE76C, ILE76I, LYS148C, LYS148I, LYS230C, LYS230I, LYS233C, LYS233I, LYS72C, MET181C, MET181I, MET182C, MET182I, MET199C, MET199I, PRO178C, PRO178I, SER184C, SER184I, SER189C, SER189I, SER190C, SER190I, SER191C, SER191I, SER201C, SER201I, SER225C, SER225I, SER248C, SER248I, THR29C, THR29I, THR30C, THR30I, THR33C, THR33I, TYR196C, TYR196I, TYR226C, TYR226I, TYR231C, TYR231I, VAL228C, VAL228I, VAL247C, VAL247I, VAL28C, VAL28I
• C-K: ALA249C, ALA249K, ARG23C, ARG35C, ARG35K, GLU31C, GLU31K, GLY32C, GLY32K, PRO25C, PRO25K, SER248C, SER248K, SER24C, SER24K, SER27C, SER27K, THR29C, THR29K, THR30K, THR33C, THR33K, TYR26C, TYR26K, VAL28C, VAL28K, VAL34C, VAL34K
• D-E: ALA134E, ALA188E, ALA18D, ALA192E, ALA20D, ALA57D, ALA95D, ARG10E, ARG23D, ARG35D, ARG70D, ARG70E, ARG71E, ARG7E, ARG99E, ASN151E, ASN224E, ASN46D, ASN4E, ASP128D, ASP128E, ASP59D, ASP6E, ASP94D, GLN137E, GLU118D, GLU16D, GLU16E, GLU62D, GLU73E, GLU74E, GLU75E, GLY122D, GLY127D, GLY136E, GLY138E, GLY15E, GLY227E, GLY41D, GLY42D, GLY55D, GLY58D, GLY64D, GLY93D, GLY97E, ILE11E, ILE130E, ILE132E, ILE17D, ILE37D, ILE43D, ILE76E, ILE89E, LEU121D, LEU124D, LEU131E, LEU139E, LEU40D, LEU78E, LEU81E, LEU8E, LYS105E, LYS123D, LYS129D, LYS129E, LYS133E, LYS140E, LYS21D, LYS5E, LYS96E, MET125D, MET150E, MET22D, MET68D, MET79E, MET91E, PRO19D, PRO25D, PRO38D, PRO63D, PRO77E, SER12E, SER189E, SER190E, SER191E, SER193E, SER225E, SER244D, SER24D, SER27D, SER52D, SER66D, SER92D, SER92E, THR194E, THR33D, THR44D, THR80E, TRP135E, TRP56D, TYR226E, TYR26D, TYR45D, TYR54D, VAL126D, VAL13E, VAL149E, VAL14E, VAL228E, VAL34D, VAL36D, VAL39D, VAL47D, VAL61D, VAL65D, VAL90E, VAL9E
• D-G: ALA179D, ALA179G, ALA188D, ALA188G, ALA200D, ALA200G, ALA249D, ALA249G, ARG232D, ARG232G, ARG23D, ARG23G, ASN202D, ASN202G, ASN224D, ASN224G, ASP197D, ASP197G, ASP205D, ASP205G, ASP221D, ASP221G, ASP223D, ASP223G, CYS246D, CYS246G, GLN220D, GLN220G, GLU31D, GLU31G, GLY183D, GLY183G, GLY185D, GLY185G, GLY187D, GLY187G, GLY227D, GLY227G, GLY229D, GLY229G, GLY250D, GLY250G, GLY252D, GLY32D, GLY32G, HIS180D, HIS180G, HIS222D, HIS222G, HIS251D, HIS251G, HIS60D, HIS60G, ILE186D, ILE186G, ILE76D, ILE76G, LYS148D, LYS148G, LYS230D, LYS230G, LYS233D, LYS233G, MET181D, MET181G, MET182D, MET182G, MET199D, MET199G, PRO178D, PRO178G, SER184D, SER184G, SER189D, SER189G, SER190D, SER190G, SER191D, SER191G, SER201D, SER201G, SER225D, SER225G, SER248D, SER248G, THR29D, THR29G, THR30D, THR30G, THR33D, THR33G, TYR196D, TYR196G, TYR226D, TYR226G, TYR231D, TYR231G, VAL228D, VAL228G, VAL247D, VAL247G, VAL28D, VAL28G
• D-H: ALA249D, ALA249H, ARG23D, ARG23H, ARG35D, ARG35H, GLU31D, GLU31H, GLY32D, GLY32H, PRO25D, PRO25H, SER248D, SER248H, SER24D, SER24H, SER27D, SER27H, THR29D, THR29H, THR33D, THR33H, TYR26D, TYR26H, VAL28D, VAL28H, VAL34D, VAL34H
• D-L: ALA209L, ALA274L, ARG273L, ARG2D, ASN166D, ASN275L, ASP143D, ASP210L, ASP278L, GLN163D, GLU164D, GLU204L, GLU269L, GLU270L, GLU272L, GLY-1D, GLY167D, GLY207L, HIS0D, HIS144D, HIS170L, ILE162D, ILE169D, LEU142D, LEU267L, LYS165D, LYS168D, LYS176L, LYS212L, MET1D, PRO172L, PRO268L, VAL173L, VAL208L, VAL271L
• D-b: ALA209D, ALA274D, ARG273D, ARG2b, ASN166b, ASP143b, ASP210D, ASP278D, GLN163b, GLU164b, GLU269D, GLU270D, GLU272D, GLY-1b, GLY167b, GLY207D, HIS0b, HIS144b, HIS170D, HIS170b, ILE162b, ILE169b, LEU142b, LEU267D, LYS165D, LYS165b, LYS168b, LYS176D, LYS212D, MET1b, PRO172D, PRO268D, VAL173D, VAL208D, VAL271D
• E-H: ALA179E, ALA179H, ALA188E, ALA188H, ALA200E, ALA200H, ALA249E, ALA249H, ARG232E, ARG232H, ARG23E, ARG23H, ASN202E, ASN202H, ASN224E, ASN224H, ASP197E, ASP197H, ASP205E, ASP205H, ASP221E, ASP221H, ASP223E, ASP223H, CYS246E, CYS246H, GLN220E, GLN220H, GLU31E, GLU31H, GLY183E, GLY183H, GLY185E, GLY185H, GLY187E, GLY187H, GLY227E, GLY227H, GLY229E, GLY229H, GLY250E, GLY250H, GLY252H, GLY32E, GLY32H, HIS180E, HIS180H, HIS222E, HIS222H, HIS251E, HIS251H, HIS60E, HIS60H, ILE186E, ILE186H, ILE76E, ILE76H, LYS148E, LYS230E, LYS230H, LYS233E, LYS233H, LYS72H, MET181E, MET181H, MET182E, MET182H, MET199E, MET199H, PRO178E, PRO178H, SER184E, SER184H, SER189E, SER189H, SER190E, SER190H, SER191E, SER191H, SER201E, SER201H, SER225E, SER225H, SER248E, SER248H, SER27E, THR29E, THR29H, THR30E, THR30H, THR33E, THR33H, TYR196E, TYR196H, TYR226E, TYR226H, TYR231E, TYR231H, VAL228E, VAL228H, VAL247E, VAL247H, VAL28E, VAL28H
• E-I: ALA249E, ALA249I, ARG23E, ARG23I, ARG35E, ARG35I, GLU31E, GLU31I, GLY32E, GLY32I, PRO25E, PRO25I, SER248E, SER248I, SER24E, SER24I, SER27E, SER27I, THR29E, THR29I, THR33E, THR33I, TYR26E, TYR26I, VAL28E, VAL28I, VAL34E, VAL34I
• E-c: ALA209c, ALA274c, ARG273c, ARG2E, ASN166E, ASP143E, ASP210c, ASP278c, GLN163E, GLN163c, GLU164E, GLU204c, GLU269c, GLU270c, GLU272c, GLY-1E, GLY167E, GLY207c, HIS0E, HIS144E, HIS170E, HIS170c, ILE162E, ILE169E, LEU142E, LEU267c, LYS165E, LYS165c, LYS168E, LYS176c, LYS212c, MET1E, PRO172c, PRO268c, VAL171c, VAL173c, VAL208c, VAL271c
• G-H: ALA134G, ALA188G, ALA18H, ALA192G, ALA20H, ALA57H, ALA95H, ARG10G, ARG23H, ARG35H, ARG70G, ARG70H, ARG71G, ARG7G, ARG99G, ASN151G, ASN224G, ASN46H, ASN4G, ASP128G, ASP128H, ASP59H, ASP6G, ASP94H, GLN137G, GLU16G, GLU16H, GLU62H, GLU73G, GLU74G, GLU75G, GLY122H, GLY127H, GLY136G, GLY138G, GLY15G, GLY227G, GLY41H, GLY42H, GLY55H, GLY58H, GLY64H, GLY93H, GLY97G, HIS60H, ILE11G, ILE130G, ILE132G, ILE17H, ILE37H, ILE43H, ILE76G, ILE89G, LEU121H, LEU124H, LEU131G, LEU139G, LEU40H, LEU78G, LEU81G, LEU8G, LYS105G, LYS123H, LYS129G, LYS133G, LYS140G, LYS148G, LYS21H, LYS5G, LYS96G, MET125H, MET150G, MET22H, MET68H, MET79G, MET91G, PRO19H, PRO25H, PRO38H, PRO63H, PRO77G, SER12G, SER189G, SER190G, SER191G, SER193G, SER225G, SER244H, SER24H, SER52H, SER66H, SER92G, SER92H, THR29H, THR33H, THR44H, THR80G, TRP135G, TRP56H, TYR226G, TYR26H, TYR45H, TYR54H, VAL126H, VAL13G, VAL149G, VAL14G, VAL228G, VAL247H, VAL34H, VAL36H, VAL39H, VAL47H, VAL61H, VAL65H, VAL90G, VAL9G
• G-J: ALA134J, ALA188J, ALA18G, ALA192J, ALA20G, ALA57G, ALA95G, ARG10J, ARG23G, ARG35G, ARG70G, ARG70J, ARG71J, ARG7J, ARG99J, ASN151J, ASN224J, ASN46G, ASN4J, ASP128G, ASP128J, ASP59G, ASP6J, ASP94G, GLN137J, GLU16G, GLU16J, GLU62G, GLU73J, GLU74J, GLU75J, GLY122G, GLY127G, GLY136J, GLY138J, GLY15J, GLY227J, GLY41G, GLY42G, GLY55G, GLY58G, GLY64G, GLY93G, GLY97J, HIS60G, ILE11J, ILE130J, ILE132J, ILE17G, ILE37G, ILE43G, ILE76J, ILE89J, LEU121G, LEU124G, LEU131J, LEU139J, LEU40G, LEU78J, LEU81J, LEU8J, LYS105J, LYS123G, LYS129J, LYS133J, LYS140J, LYS148J, LYS21G, LYS5J, LYS96J, MET125G, MET150J, MET22G, MET68G, MET79J, MET91J, PRO19G, PRO25G, PRO38G, PRO63G, PRO77J, SER12J, SER189J, SER190J, SER191J, SER193J, SER225J, SER244G, SER24G, SER27G, SER52G, SER66G, SER92G, SER92J, THR194J, THR33G, THR44G, THR80J, TRP135J, TRP56G, TYR226J, TYR26G, TYR45G, TYR54G, VAL126G, VAL13J, VAL149J, VAL14J, VAL228J, VAL34G, VAL36G, VAL39G, VAL47G, VAL61G, VAL65G, VAL90J, VAL9J
• H-I: ALA134H, ALA188H, ALA18I, ALA192H, ALA20I, ALA57I, ALA95I, ARG10H, ARG23I, ARG35I, ARG70H, ARG70I, ARG71H, ARG7H, ARG99H, ASN151H, ASN224H, ASN46I, ASN4H, ASP128H, ASP128I, ASP59I, ASP6H, ASP94I, GLN137H, GLU118I, GLU16H, GLU16I, GLU62I, GLU73H, GLU74H, GLU75H, GLY122I, GLY127I, GLY136H, GLY138H, GLY15H, GLY227H, GLY41I, GLY42I, GLY55I, GLY58I, GLY64I, GLY93I, GLY97H, ILE11H, ILE130H, ILE132H, ILE17I, ILE37I, ILE43I, ILE76H, ILE89H, LEU121I, LEU124I, LEU131H, LEU139H, LEU40I, LEU78H, LEU81H, LEU8H, LYS105H, LYS123I, LYS129H, LYS129I, LYS133H, LYS140H, LYS21I, LYS5H, LYS96H, MET125I, MET150H, MET22I, MET68I, MET79H, MET91H, PRO19I, PRO25I, PRO38I, PRO63I, PRO77H, SER12H, SER189H, SER190H, SER191H, SER193H, SER225H, SER244I, SER24I, SER27I, SER52I, SER66I, SER92H, SER92I, THR33I, THR44I, THR80H, TRP135H, TRP56I, TYR226H, TYR26I, TYR45I, TYR54I, VAL126I, VAL13H, VAL149H, VAL14H, VAL228H, VAL34I, VAL36I, VAL39I, VAL47I, VAL61I, VAL65I, VAL90H, VAL9H
• I-K: ALA134I, ALA188I, ALA18K, ALA192I, ALA20K, ALA57K, ALA95K, ARG10I, ARG23K, ARG35K, ARG70I, ARG70K, ARG71I, ARG7I, ARG99I, ASN151I, ASN224I, ASN46K, ASN4I, ASP128I, ASP128K, ASP59K, ASP6I, ASP94K, CYS83I, GLN137I, GLU118K, GLU16I, GLU16K, GLU62K, GLU73I, GLU74I, GLU75I, GLY122K, GLY127K, GLY136I, GLY138I, GLY15I, GLY227I, GLY41K, GLY42K, GLY55K, GLY58K, GLY64K, GLY93K, GLY97I, HIS111K, HIS60K, ILE11I, ILE130I, ILE132I, ILE17K, ILE37K, ILE43K, ILE76I, ILE89I, LEU121K, LEU124K, LEU131I, LEU139I, LEU40K, LEU78I, LEU81I, LEU8I, LYS105I, LYS123K, LYS129I, LYS133I, LYS140I, LYS148I, LYS21K, LYS5I, LYS96I, MET125K, MET150I, MET22K, MET68K, MET79I, MET91I, PRO19K, PRO25K, PRO38K, PRO63K, PRO77I, SER12I, SER189I, SER190I, SER191I, SER193I, SER225I, SER244K, SER24K, SER52K, SER66K, SER92I, SER92K, THR33K, THR44K, THR80I, TRP135I, TRP56K, TYR226I, TYR26K, TYR45K, TYR54K, VAL126K, VAL13I, VAL149I, VAL14I, VAL228I, VAL34K, VAL36K, VAL39K, VAL47K, VAL61K, VAL65K, VAL90I, VAL9I
• J-K: ALA134K, ALA188K, ALA18J, ALA192K, ALA20J, ALA57J, ALA95J, ARG10K, ARG23J, ARG35J, ARG70J, ARG70K, ARG71K, ARG7K, ARG99K, ASN151K, ASN46J, ASN4K, ASP128J, ASP128K, ASP59J, ASP6K, ASP94J, GLN137K, GLU118J, GLU16J, GLU16K, GLU62J, GLU73K, GLU74K, GLU75K, GLY122J, GLY127J, GLY136K, GLY138K, GLY15K, GLY227K, GLY41J, GLY42J, GLY55J, GLY58J, GLY64J, GLY93J, GLY97K, HIS60J, ILE11K, ILE130K, ILE132K, ILE17J, ILE37J, ILE43J, ILE76K, ILE89K, LEU121J, LEU124J, LEU131K, LEU139K, LEU40J, LEU78K, LEU81K, LEU8K, LYS105K, LYS123J, LYS129J, LYS129K, LYS133K, LYS140K, LYS21J, LYS5K, LYS96K, MET125J, MET150K, MET22J, MET68J, MET79K, MET91K, PRO19J, PRO25J, PRO38J, PRO63J, PRO77K, SER12K, SER189K, SER190K, SER191K, SER193K, SER225K, SER244J, SER24J, SER27J, SER52J, SER66J, SER92J, SER92K, THR194K, THR33J, THR44J, THR80K, TRP135K, TRP56J, TYR226K, TYR26J, TYR45J, TYR54J, VAL126J, VAL13K, VAL149K, VAL14K, VAL228K, VAL34J, VAL36J, VAL39J, VAL47J, VAL61J, VAL65J, VAL90K, VAL9K
• L-M: ALA134L, ALA188L, ALA18M, ALA192L, ALA20M, ALA57M, ALA95M, ARG10L, ARG23M, ARG35M, ARG70L, ARG70M, ARG71L, ARG7L, ARG99L, ASN151L, ASN224L, ASN46M, ASN4L, ASP128L, ASP128M, ASP59M, ASP6L, ASP94M, GLN137L, GLU16L, GLU16M, GLU62M, GLU73L, GLU74L, GLU75L, GLY122M, GLY127M, GLY136L, GLY138L, GLY15L, GLY227L, GLY41M, GLY42M, GLY55M, GLY58M, GLY64M, GLY93M, GLY97L, HIS111M, ILE11L, ILE130L, ILE132L, ILE17M, ILE37M, ILE43M, ILE76L, ILE89L, LEU121M, LEU124M, LEU131L, LEU139L, LEU40M, LEU78L, LEU81L, LEU8L, LYS105L, LYS123M, LYS129L, LYS133L, LYS140L, LYS148L, LYS21M, LYS5L, LYS96L, MET125M, MET150L, MET22M, MET68M, MET79L, MET91L, PRO19M, PRO25M, PRO38M, PRO63M, PRO77L, SER12L, SER189L, SER190L, SER191L, SER193L, SER225L, SER244M, SER24M, SER52M, SER66M, SER92L, SER92M, THR33M, THR44M, THR80L, TRP135L, TRP56M, TYR226L, TYR26M, TYR45M, TYR54M, VAL126M, VAL13L, VAL149L, VAL14L, VAL228L, VAL34M, VAL36M, VAL39M, VAL47M, VAL61M, VAL65M, VAL90L, VAL9L
• L-O: ALA134O, ALA188O, ALA18L, ALA192O, ALA20L, ALA57L, ALA95L, ARG10O, ARG23L, ARG35L, ARG70L, ARG70O, ARG71O, ARG7O, ARG99O, ASN151O, ASN224O, ASN46L, ASN4O, ASP128L, ASP128O, ASP59L, ASP6O, ASP94L, GLN137O, GLU16L, GLU16O, GLU62L, GLU73O, GLU74O, GLU75O, GLY122L, GLY127L, GLY136O, GLY138O, GLY15O, GLY227O, GLY41L, GLY42L, GLY55L, GLY58L, GLY64L, GLY93L, GLY97O, HIS60L, ILE11O, ILE130O, ILE132O, ILE17L, ILE37L, ILE43L, ILE76O, ILE89O, LEU121L, LEU124L, LEU131O, LEU139O, LEU40L, LEU78O, LEU81O, LEU8O, LYS105O, LYS123L, LYS129L, LYS129O, LYS133O, LYS140O, LYS148O, LYS21L, LYS5O, LYS96O, MET125L, MET150O, MET22L, MET68L, MET79O, MET91O, PRO19L, PRO25L, PRO38L, PRO63L, PRO77O, SER12O, SER189O, SER190O, SER191O, SER193O, SER225O, SER244L, SER24L, SER52L, SER66L, SER92L, SER92O, THR194O, THR33L, THR44L, THR80O, TRP135O, TRP56L, TYR226O, TYR26L, TYR45L, TYR54L, VAL126L, VAL13O, VAL149O, VAL14O, VAL228O, VAL34L, VAL36L, VAL39L, VAL47L, VAL61L, VAL65L, VAL90O, VAL9O
• L-S: ALA249L, ALA249S, ARG23L, ARG23S, ARG35L, ARG35S, GLU31L, GLU31S, GLY32L, GLY32S, PRO25L, PRO25S, SER248L, SER248S, SER24L, SER24S, SER27L, SER27S, THR29L, THR29S, THR33L, THR33S, TYR26L, TYR26S, VAL28L, VAL28S, VAL34L, VAL34S
• L-V: ALA179L, ALA179V, ALA188L, ALA188V, ALA200L, ALA200V, ALA249L, ALA249V, ARG232L, ARG232V, ARG23L, ARG23V, ASN202L, ASN202V, ASN224L, ASN224V, ASP197L, ASP197V, ASP205L, ASP205V, ASP221L, ASP221V, ASP223L, ASP223V, CYS246L, CYS246V, GLN220L, GLN220V, GLU31L, GLU31V, GLY183L, GLY183V, GLY185L, GLY185V, GLY187L, GLY187V, GLY227L, GLY227V, GLY229L, GLY229V, GLY250L, GLY250V, GLY252L, GLY252V, GLY32L, GLY32V, HIS180L, HIS180V, HIS222L, HIS222V, HIS251L, HIS251V, HIS60L, HIS60V, ILE186L, ILE186V, ILE76L, ILE76V, LYS148L, LYS148V, LYS230L, LYS230V, LYS233L, LYS233V, LYS72L, LYS72V, MET181L, MET181V, MET182L, MET182V, MET199L, MET199V, PRO178L, PRO178V, SER184L, SER184V, SER189L, SER189V, SER190L, SER190V, SER191L, SER191V, SER201L, SER201V, SER225L, SER225V, SER248L, SER248V, SER27L, THR29L, THR29V, THR30L, THR30V, THR33L, THR33V, TYR196L, TYR196V, TYR226L, TYR226V, TYR231L, TYR231V, VAL228L, VAL228V, VAL247L, VAL247V, VAL28L, VAL28V
• L-b: ALA209b, ALA274b, ARG273b, ARG2L, ASN166L, ASP143L, ASP210b, ASP278b, GLN163L, GLN163b, GLU164L, GLU269b, GLU270b, GLU272b, GLY-1L, GLY167L, GLY207b, HIS0L, HIS144L, HIS170L, HIS170b, ILE162L, LEU142L, LEU267b, LYS165L, LYS165b, LYS168L, LYS176b, LYS212b, MET1L, PRO172b, PRO268b, VAL171b, VAL173b, VAL208b, VAL271b
• M-N: ALA134M, ALA188M, ALA18N, ALA192M, ALA20N, ALA57N, ALA95N, ARG10M, ARG23N, ARG35N, ARG70M, ARG70N, ARG71M, ARG7M, ARG99M, ASN151M, ASN224M, ASN46N, ASN4M, ASP128M, ASP128N, ASP59N, ASP6M, ASP94N, GLN137M, GLU118N, GLU16M, GLU16N, GLU62N, GLU73M, GLU74M, GLU75M, GLY122N, GLY127N, GLY136M, GLY138M, GLY15M, GLY227M, GLY41N, GLY42N, GLY55N, GLY58N, GLY64N, GLY93N, GLY97M, HIS60N, ILE11M, ILE130M, ILE132M, ILE17N, ILE37N, ILE43N, ILE76M, ILE89M, LEU121N, LEU124N, LEU131M, LEU139M, LEU40N, LEU78M, LEU81M, LEU8M, LYS105M, LYS123N, LYS129M, LYS129N, LYS133M, LYS140M, LYS148M, LYS21N, LYS5M, LYS96M, MET125N, MET150M, MET22N, MET68N, MET79M, MET91M, PRO19N, PRO25N, PRO38N, PRO63N, PRO77M, SER12M, SER189M, SER190M, SER191M, SER193M, SER225M, SER244N, SER24N, SER52N, SER66N, SER92M, SER92N, THR29N, THR33N, THR44N, THR80M, TRP135M, TRP56N, TYR226M, TYR26N, TYR45N, TYR54N, VAL126N, VAL13M, VAL149M, VAL14M, VAL228M, VAL34N, VAL36N, VAL39N, VAL47N, VAL61N, VAL65N, VAL90M, VAL9M
• M-V: ALA249M, ALA249V, ARG23M, ARG23V, ARG35M, ARG35V, GLU31M, GLU31V, GLY32M, GLY32V, PRO25M, PRO25V, SER248M, SER248V, SER24M, SER24V, SER27M, SER27V, THR29M, THR29V, THR33M, THR33V, TYR26M, TYR26V, VAL28M, VAL28V, VAL34M, VAL34V
• M-X: ALA179M, ALA179X, ALA188M, ALA188X, ALA200M, ALA200X, ALA249M, ALA249X, ARG232M, ARG232X, ARG23M, ARG23X, ASN202M, ASN202X, ASN224M, ASN224X, ASP197M, ASP197X, ASP205M, ASP205X, ASP221M, ASP221X, ASP223M, ASP223X, CYS246M, CYS246X, GLN220M, GLN220X, GLU31M, GLU31X, GLY183M, GLY183X, GLY185M, GLY185X, GLY187M, GLY187X, GLY227M, GLY227X, GLY229M, GLY229X, GLY250M, GLY250X, GLY32M, GLY32X, HIS180M, HIS180X, HIS222M, HIS222X, HIS251M, HIS251X, HIS60M, HIS60X, ILE186M, ILE186X, ILE76M, ILE76X, LYS148M, LYS148X, LYS230M, LYS230X, LYS233M, LYS233X, LYS72X, MET181M, MET181X, MET182M, MET182X, MET199M, MET199X, PRO178M, PRO178X, SER184M, SER184X, SER189M, SER189X, SER190M, SER190X, SER191M, SER191X, SER201M, SER201X, SER225M, SER225X, SER248M, SER248X, THR29M, THR29X, THR30M, THR30X, THR33M, THR33X, TYR196M, TYR196X, TYR226M, TYR226X, TYR231M, TYR231X, VAL228M, VAL228X, VAL247M, VAL247X, VAL28M, VAL28X
• M-a: ALA209M, ALA274M, ARG273M, ARG2a, ASN166a, ASP143a, ASP210M, ASP278M, GLN163M, GLN163a, GLU164a, GLU269M, GLU270M, GLU272M, GLY-1a, GLY167a, GLY207M, HIS0a, HIS144a, HIS170M, ILE162a, ILE169a, LEU142a, LEU267M, LYS165M, LYS165a, LYS168a, LYS176M, LYS212M, MET1a, PRO172M, PRO268M, VAL173M, VAL208M, VAL271M
• N-P: ALA134N, ALA188N, ALA18P, ALA192N, ALA20P, ALA57P, ALA95P, ARG10N, ARG23P, ARG35P, ARG70N, ARG70P, ARG71N, ARG7N, ARG99N, ASN151N, ASN224N, ASN46P, ASN4N, ASP128N, ASP128P, ASP59P, ASP6N, ASP94P, CYS83N, GLN137N, GLU16N, GLU16P, GLU62P, GLU73N, GLU74N, GLU75N, GLY122P, GLY127P, GLY136N, GLY138N, GLY15N, GLY227N, GLY41P, GLY42P, GLY55P, GLY58P, GLY64P, GLY93P, GLY97N, HIS111P, HIS60P, ILE11N, ILE130N, ILE132N, ILE17P, ILE37P, ILE43P, ILE76N, ILE89N, LEU121P, LEU124P, LEU131N, LEU139N, LEU40P, LEU78N, LEU81N, LEU8N, LYS105N, LYS123P, LYS129N, LYS129P, LYS133N, LYS140N, LYS148N, LYS21P, LYS5N, LYS96N, MET125P, MET150N, MET22P, MET68P, MET79N, MET91N, PRO19P, PRO25P, PRO38P, PRO63P, PRO77N, SER12N, SER189N, SER190N, SER191N, SER193N, SER225N, SER244P, SER24P, SER27P, SER52P, SER66P, SER92N, SER92P, THR194N, THR33P, THR44P, THR80N, TRP135N, TRP56P, TYR226N, TYR26P, TYR45P, TYR54P, VAL126P, VAL13N, VAL149N, VAL14N, VAL228N, VAL34P, VAL36P, VAL39P, VAL47P, VAL61P, VAL65P, VAL90N, VAL9N
• N-U: ALA179N, ALA179U, ALA188N, ALA188U, ALA200N, ALA200U, ALA249N, ALA249U, ARG232N, ARG232U, ARG23N, ARG23U, ASN202N, ASN202U, ASN224N, ASN224U, ASP197N, ASP197U, ASP205N, ASP205U, ASP221N, ASP221U, ASP223N, ASP223U, CYS246N, CYS246U, GLN220N, GLN220U, GLU31N, GLU31U, GLY183N, GLY183U, GLY185N, GLY185U, GLY187N, GLY187U, GLY227N, GLY227U, GLY229N, GLY229U, GLY250N, GLY250U, GLY32N, GLY32U, HIS180N, HIS180U, HIS222N, HIS222U, HIS251N, HIS251U, HIS60N, HIS60U, ILE186N, ILE186U, ILE76N, ILE76U, LYS148N, LYS148U, LYS230N, LYS230U, LYS233N, LYS233U, LYS72N, LYS72U, MET181N, MET181U, MET182N, MET182U, MET199N, MET199U, PRO178N, PRO178U, SER184N, SER184U, SER189N, SER189U, SER190N, SER190U, SER191N, SER191U, SER201N, SER201U, SER225N, SER225U, SER248N, SER248U, THR29N, THR29U, THR30N, THR30U, THR33N, THR33U, TYR196N, TYR196U, TYR226N, TYR226U, TYR231N, TYR231U, VAL228N, VAL228U, VAL247N, VAL247U, VAL28N, VAL28U
• N-X: ALA249N, ALA249X, ARG23N, ARG23X, ARG35N, ARG35X, GLU31N, GLU31X, GLY32N, GLY32X, PRO25N, PRO25X, SER248N, SER248X, SER24N, SER24X, SER27N, SER27X, THR29N, THR29X, THR30X, THR33N, THR33X, TYR26N, TYR26X, VAL28N, VAL28X, VAL34N, VAL34X
• O-P: ALA134P, ALA188P, ALA18O, ALA192P, ALA20O, ALA57O, ALA95O, ARG10P, ARG23O, ARG35O, ARG70O, ARG70P, ARG71P, ARG7P, ARG99P, ASN151P, ASN224P, ASN46O, ASN4P, ASP128O, ASP128P, ASP59O, ASP6P, ASP94O, CYS83P, GLN137P, GLU16O, GLU16P, GLU62O, GLU73P, GLU74P, GLU75P, GLY122O, GLY127O, GLY136P, GLY138P, GLY15P, GLY227P, GLY41O, GLY42O, GLY55O, GLY58O, GLY64O, GLY93O, GLY97P, HIS111O, HIS60O, ILE11P, ILE130P, ILE132P, ILE17O, ILE37O, ILE43O, ILE76P, ILE89P, LEU121O, LEU124O, LEU131P, LEU139P, LEU40O, LEU78P, LEU81P, LEU8P, LYS105P, LYS123O, LYS129P, LYS133P, LYS140P, LYS148P, LYS21O, LYS5P, LYS96P, MET125O, MET150P, MET22O, MET68O, MET79P, MET91P, PRO19O, PRO25O, PRO38O, PRO63O, PRO77P, SER12P, SER189P, SER190P, SER191P, SER193P, SER225P, SER244O, SER24O, SER52O, SER66O, SER92O, SER92P, THR33O, THR44O, THR80P, TRP135P, TRP56O, TYR226P, TYR26O, TYR45O, TYR54O, VAL126O, VAL13P, VAL149P, VAL14P, VAL228P, VAL34O, VAL36O, VAL39O, VAL47O, VAL61O, VAL65O, VAL90P, VAL9P
• O-S: ALA179O, ALA179S, ALA188O, ALA188S, ALA200O, ALA200S, ALA249O, ALA249S, ARG232O, ARG232S, ARG23O, ARG23S, ASN202O, ASN202S, ASN224O, ASN224S, ASP197O, ASP197S, ASP205O, ASP205S, ASP221O, ASP221S, ASP223O, ASP223S, CYS246O, CYS246S, GLN220O, GLN220S, GLU31O, GLU31S, GLY183O, GLY183S, GLY185O, GLY185S, GLY187O, GLY187S, GLY227O, GLY227S, GLY229O, GLY229S, GLY250O, GLY250S, GLY32O, GLY32S, HIS180O, HIS180S, HIS222O, HIS222S, HIS251O, HIS251S, HIS60O, HIS60S, ILE186O, ILE186S, ILE76O, ILE76S, LYS148O, LYS230O, LYS230S, LYS233O, LYS233S, LYS72S, MET181O, MET181S, MET182O, MET182S, MET199O, MET199S, PRO178O, PRO178S, SER184O, SER184S, SER189O, SER189S, SER190O, SER190S, SER191O, SER191S, SER201O, SER201S, SER225O, SER225S, SER248O, SER248S, THR29O, THR29S, THR30O, THR30S, THR33O, THR33S, TYR196O, TYR196S, TYR226O, TYR226S, TYR231O, TYR231S, VAL228O, VAL228S, VAL247O, VAL247S, VAL28O, VAL28S
• O-T: ALA249O, ALA249T, ARG23O, ARG23T, ARG35O, ARG35T, GLU31O, GLU31T, GLY32O, GLY32T, PRO25O, PRO25T, SER248O, SER248T, SER24O, SER24T, SER27O, SER27T, THR29O, THR29T, THR30O, THR30T, THR33O, THR33T, TYR26O, TYR26T, VAL28O, VAL28T, VAL34O, VAL34T
• P-T: ALA179P, ALA179T, ALA188P, ALA188T, ALA200P, ALA200T, ALA249P, ALA249T, ARG232P, ARG232T, ARG23P, ARG23T, ASN202P, ASN202T, ASN224P, ASN224T, ASP197P, ASP197T, ASP205P, ASP205T, ASP221P, ASP221T, ASP223P, ASP223T, CYS246P, CYS246T, GLN220P, GLN220T, GLU31P, GLU31T, GLY183P, GLY183T, GLY185P, GLY185T, GLY187P, GLY187T, GLY227P, GLY227T, GLY229P, GLY229T, GLY250P, GLY250T, GLY252P, GLY32P, GLY32T, HIS180P, HIS180T, HIS222P, HIS222T, HIS251P, HIS251T, HIS60P, HIS60T, ILE186P, ILE186T, ILE76P, ILE76T, LYS148P, LYS148T, LYS230P, LYS230T, LYS233P, LYS233T, LYS72P, MET181P, MET181T, MET182P, MET182T, MET199P, MET199T, PRO178P, PRO178T, SER184P, SER184T, SER189P, SER189T, SER190P, SER190T, SER191P, SER191T, SER201P, SER201T, SER225P, SER225T, SER248P, SER248T, THR29P, THR29T, THR30P, THR30T, THR33P, THR33T, TYR196P, TYR196T, TYR226P, TYR226T, TYR231P, TYR231T, VAL228P, VAL228T, VAL247P, VAL247T, VAL28P, VAL28T
• P-U: ALA249P, ALA249U, ARG23U, ARG35P, ARG35U, GLU31P, GLU31U, GLY32P, GLY32U, PRO25P, PRO25U, SER248P, SER248U, SER24P, SER24U, SER27P, SER27U, THR29P, THR29U, THR30P, THR30U, THR33P, THR33U, TYR26P, TYR26U, VAL28P, VAL28U, VAL34P, VAL34U
• S-T: ALA134S, ALA188S, ALA18T, ALA192S, ALA20T, ALA57T, ALA95T, ARG10S, ARG23T, ARG35T, ARG70S, ARG70T, ARG71S, ARG7S, ARG99S, ASN151S, ASN46T, ASN4S, ASP128S, ASP128T, ASP59T, ASP6S, ASP94T, CYS83S, GLN137S, GLU16S, GLU16T, GLU62T, GLU73S, GLU74S, GLU75S, GLY122T, GLY127T, GLY136S, GLY138S, GLY15S, GLY227S, GLY41T, GLY42T, GLY55T, GLY58T, GLY64T, GLY93T, GLY97S, HIS111T, ILE11S, ILE130S, ILE132S, ILE17T, ILE37T, ILE43T, ILE76S, ILE89S, LEU121T, LEU124T, LEU131S, LEU139S, LEU40T, LEU78S, LEU81S, LEU8S, LYS105S, LYS123T, LYS129S, LYS129T, LYS133S, LYS140S, LYS21T, LYS5S, LYS96S, MET125T, MET150S, MET22T, MET68T, MET79S, MET91S, PRO19T, PRO25T, PRO38T, PRO63T, PRO77S, SER12S, SER189S, SER190S, SER191S, SER193S, SER225S, SER244T, SER24T, SER27T, SER52T, SER66T, SER92S, SER92T, THR33T, THR44T, THR80S, TRP135S, TRP56T, TYR226S, TYR26T, TYR45T, TYR54T, VAL126T, VAL13S, VAL149S, VAL14S, VAL228S, VAL34T, VAL36T, VAL39T, VAL47T, VAL61T, VAL65T, VAL90S, VAL9S
• S-V: ALA134V, ALA188V, ALA18S, ALA192V, ALA20S, ALA57S, ALA95S, ARG10V, ARG23S, ARG35S, ARG70S, ARG70V, ARG71V, ARG7V, ARG99V, ASN151V, ASN224V, ASN46S, ASN4V, ASP128S, ASP128V, ASP59S, ASP6V, ASP94S, GLN137V, GLU16S, GLU16V, GLU62S, GLU73V, GLU74V, GLU75V, GLY122S, GLY127S, GLY136V, GLY138V, GLY15V, GLY227V, GLY41S, GLY42S, GLY55S, GLY58S, GLY64S, GLY93S, GLY97V, HIS60S, ILE11V, ILE130V, ILE132V, ILE17S, ILE37S, ILE43S, ILE76V, ILE89V, LEU121S, LEU124S, LEU131V, LEU139V, LEU40S, LEU78V, LEU81V, LEU8V, LYS105V, LYS123S, LYS129V, LYS133V, LYS140V, LYS21S, LYS5V, LYS96V, MET125S, MET150V, MET22S, MET68S, MET79V, MET91V, PRO19S, PRO25S, PRO38S, PRO63S, PRO77V, SER12V, SER189V, SER190V, SER191V, SER193V, SER225V, SER244S, SER24S, SER52S, SER66S, SER92S, SER92V, THR29S, THR33S, THR44S, THR80V, TRP135V, TRP56S, TYR226V, TYR26S, TYR45S, TYR54S, VAL126S, VAL13V, VAL149V, VAL14V, VAL228V, VAL34S, VAL36S, VAL39S, VAL47S, VAL61S, VAL65S, VAL90V, VAL9V
• T-U: ALA134T, ALA188T, ALA18U, ALA192T, ALA20U, ALA57U, ALA95U, ARG10T, ARG23U, ARG35U, ARG70T, ARG70U, ARG71T, ARG7T, ARG99T, ASN151T, ASN224T, ASN46U, ASN4T, ASP128T, ASP128U, ASP59U, ASP6T, ASP94U, CYS83T, GLN137T, GLU16T, GLU16U, GLU62U, GLU73T, GLU74T, GLU75T, GLY122U, GLY127U, GLY136T, GLY138T, GLY15T, GLY227T, GLY41U, GLY42U, GLY55U, GLY58U, GLY64U, GLY93U, GLY97T, HIS111U, HIS60U, ILE11T, ILE130T, ILE132T, ILE17U, ILE37U, ILE43U, ILE76T, ILE89T, LEU121U, LEU124U, LEU131T, LEU139T, LEU40U, LEU78T, LEU81T, LEU8T, LYS105T, LYS123U, LYS129T, LYS133T, LYS140T, LYS148T, LYS21U, LYS5T, LYS96T, MET125U, MET150T, MET22U, MET68U, MET79T, MET91T, PRO19U, PRO25U, PRO38U, PRO63U, PRO77T, SER12T, SER189T, SER190T, SER191T, SER193T, SER225T, SER244U, SER24U, SER27U, SER52U, SER66U, SER92T, SER92U, THR33U, THR44U, THR80T, TRP135T, TRP56U, TYR226T, TYR26U, TYR45U, TYR54U, VAL126U, VAL13T, VAL149T, VAL14T, VAL228T, VAL34U, VAL36U, VAL39U, VAL47U, VAL61U, VAL65U, VAL90T, VAL9T
• U-X: ALA134U, ALA188U, ALA18X, ALA192U, ALA20X, ALA57X, ALA95X, ARG10U, ARG23X, ARG35X, ARG70U, ARG70X, ARG71U, ARG7U, ARG99U, ASN151U, ASN224U, ASN46X, ASN4U, ASP128U, ASP128X, ASP59X, ASP6U, ASP94X, GLN137U, GLU118X, GLU16U, GLU16X, GLU62X, GLU73U, GLU74U, GLU75U, GLY122X, GLY127X, GLY136U, GLY138U, GLY15U, GLY227U, GLY41X, GLY42X, GLY55X, GLY58X, GLY64X, GLY93X, GLY97U, ILE11U, ILE130U, ILE132U, ILE17X, ILE37X, ILE43X, ILE76U, ILE89U, LEU121X, LEU124X, LEU131U, LEU139U, LEU40X, LEU78U, LEU81U, LEU8U, LYS105U, LYS123X, LYS129U, LYS133U, LYS140U, LYS148U, LYS21X, LYS5U, LYS96U, MET125X, MET150U, MET22X, MET68X, MET79U, MET91U, PRO19X, PRO25X, PRO38X, PRO63X, PRO77U, SER12U, SER189U, SER190U, SER191U, SER193U, SER225U, SER244X, SER24X, SER27X, SER52X, SER66X, SER92U, SER92X, THR33X, THR44X, THR80U, TRP135U, TRP56X, TYR226U, TYR26X, TYR45X, TYR54X, VAL126X, VAL13U, VAL149U, VAL14U, VAL228U, VAL34X, VAL36X, VAL39X, VAL47X, VAL61X, VAL65X, VAL90U, VAL9U
• V-X: ALA134X, ALA188X, ALA18V, ALA192X, ALA20V, ALA57V, ALA95V, ARG10X, ARG23V, ARG35V, ARG70V, ARG70X, ARG71X, ARG7X, ARG99X, ASN151X, ASN224X, ASN46V, ASN4X, ASP128V, ASP128X, ASP59V, ASP6X, ASP94V, GLN137X, GLU16V, GLU16X, GLU62V, GLU73X, GLU74X, GLU75X, GLY122V, GLY127V, GLY136X, GLY138X, GLY15X, GLY227X, GLY41V, GLY42V, GLY55V, GLY58V, GLY64V, GLY93V, GLY97X, ILE11X, ILE130X, ILE132X, ILE17V, ILE37V, ILE43V, ILE76X, ILE89X, LEU121V, LEU124V, LEU131X, LEU139X, LEU40V, LEU78X, LEU81X, LEU8X, LYS105X, LYS123V, LYS129V, LYS129X, LYS133X, LYS140X, LYS148X, LYS21V, LYS5X, LYS96X, MET125V, MET150X, MET22V, MET68V, MET79X, MET91X, PRO19V, PRO25V, PRO38V, PRO63V, PRO77X, SER12X, SER189X, SER190X, SER191X, SER193X, SER225X, SER244V, SER24V, SER27V, SER52V, SER66V, SER92V, SER92X, THR33V, THR44V, THR80X, TRP135X, TRP56V, TYR226X, TYR26V, TYR45V, TYR54V, VAL126V, VAL13X, VAL149X, VAL14X, VAL228X, VAL34V, VAL36V, VAL39V, VAL47V, VAL61V, VAL65V, VAL90X, VAL9X
• a-b: ALA134a, ALA188a, ALA18b, ALA192a, ALA20b, ALA57b, ALA95b, ARG10a, ARG23b, ARG35b, ARG70a, ARG70b, ARG71a, ARG7a, ARG99a, ASN151a, ASN224a, ASN46b, ASN4a, ASP128a, ASP128b, ASP59b, ASP6a, ASP94b, CYS83a, GLN137a, GLU16a, GLU16b, GLU62b, GLU73a, GLU74a, GLU75a, GLY122b, GLY127b, GLY136a, GLY138a, GLY15a, GLY227a, GLY41b, GLY42b, GLY55b, GLY58b, GLY64b, GLY93b, GLY97a, HIS60b, ILE11a, ILE130a, ILE132a, ILE17b, ILE37b, ILE43b, ILE76a, ILE89a, LEU121b, LEU124b, LEU131a, LEU139a, LEU40b, LEU78a, LEU81a, LEU8a, LYS105a, LYS123b, LYS129a, LYS129b, LYS133a, LYS140a, LYS148a, LYS21b, LYS5a, LYS96a, MET125b, MET150a, MET22b, MET68b, MET79a, MET91a, PRO19b, PRO25b, PRO38b, PRO63b, PRO77a, SER12a, SER189a, SER190a, SER191a, SER193a, SER225a, SER244b, SER24b, SER27b, SER52b, SER66b, SER92a, SER92b, THR194a, THR33b, THR44b, THR80a, TRP135a, TRP56b, TYR226a, TYR26b, TYR45b, TYR54b, VAL126b, VAL13a, VAL149a, VAL14a, VAL228a, VAL34b, VAL36b, VAL39b, VAL47b, VAL61b, VAL65b, VAL90a, VAL9a
• a-d: ALA134d, ALA18a, ALA20a, ALA57a, ALA95a, ARG10d, ARG23a, ARG35a, ARG70a, ARG70d, ARG71d, ARG7d, ARG99d, ASN151d, ASN46a, ASN4d, ASP128a, ASP128d, ASP59a, ASP6d, ASP94a, CYS83d, GLN137d, GLU16a, GLU16d, GLU62a, GLU73d, GLU74d, GLU75d, GLY122a, GLY127a, GLY136d, GLY138d, GLY15d, GLY41a, GLY42a, GLY55a, GLY58a, GLY64a, GLY93a, GLY97d, HIS111a, HIS60a, ILE11d, ILE130d, ILE132d, ILE17a, ILE37a, ILE43a, ILE76d, ILE89d, LEU121a, LEU124a, LEU131d, LEU139d, LEU40a, LEU78d, LEU81d, LEU8d, LYS105d, LYS123a, LYS129d, LYS133d, LYS140d, LYS148d, LYS21a, LYS5d, LYS96d, MET125a, MET150d, MET22a, MET68a, MET79d, MET91d, PRO19a, PRO25a, PRO38a, PRO63a, PRO77d, SER12d, SER244a, SER24a, SER27a, SER52a, SER66a, SER92a, SER92d, THR29a, THR44a, THR80d, TRP135d, TRP56a, TYR26a, TYR45a, TYR54a, VAL126a, VAL13d, VAL149d, VAL14d, VAL36a, VAL39a, VAL47a, VAL61a, VAL65a, VAL90d, VAL9d
• a-g: GLY32a, GLY32g, VAL34a, VAL34g
• a-j: ASP221a, ASP221j, GLY187a, GLY187j, HIS180a, HIS180j, HIS222a, HIS222j, HIS251a, HIS251j, LYS230a, LYS233a, LYS233j, SER201j
• b-c: ALA134b, ALA188b, ALA18c, ALA192b, ALA20c, ALA57c, ALA95c, ARG10b, ARG23c, ARG35c, ARG70b, ARG70c, ARG71b, ARG7b, ARG99b, ASN151b, ASN224b, ASN46c, ASN4b, ASP128b, ASP128c, ASP59c, ASP6b, ASP94c, CYS83b, GLN137b, GLU118c, GLU16b, GLU16c, GLU62c, GLU73b, GLU74b, GLU75b, GLY122c, GLY127c, GLY136b, GLY138b, GLY15b, GLY227b, GLY41c, GLY42c, GLY55c, GLY58c, GLY64c, GLY93c, GLY97b, ILE11b, ILE130b, ILE132b, ILE17c, ILE37c, ILE43c, ILE76b, ILE89b, LEU121c, LEU124c, LEU131b, LEU139b, LEU40c, LEU78b, LEU81b, LEU8b, LYS105b, LYS123c, LYS129b, LYS129c, LYS133b, LYS140b, LYS148b, LYS21c, LYS5b, LYS96b, MET125c, MET150b, MET22c, MET68c, MET79b, MET91b, PRO19c, PRO25c, PRO38c, PRO63c, PRO77b, SER12b, SER189b, SER190b, SER191b, SER193b, SER225b, SER244c, SER24c, SER27c, SER52c, SER66c, SER92b, SER92c, THR33c, THR44c, THR80b, TRP135b, TRP56c, TYR226b, TYR26c, TYR45c, TYR54c, VAL126c, VAL13b, VAL149b, VAL14b, VAL228b, VAL34c, VAL36c, VAL39c, VAL47c, VAL61c, VAL65c, VAL90b, VAL9b
• b-j: GLY32b, GLY32j, VAL34b, VAL34j
• b-k: ASP221b, ASP221k, GLU31b, GLY187b, GLY187k, HIS180b, HIS180k, HIS222b, HIS222k, HIS251b, HIS251k, LYS230b, LYS230k, LYS233b, LYS233k, SER201k
• c-e: ALA57e, ARG10c, ARG7c, ASN46e, ASP94e, GLU73c, GLU74c, ILE43e, LEU8c, LYS21e, LYS96c, SER12c, TYR45e
• c-i: ASP221c, ASP221i, GLY187c, GLY187i, HIS180c, HIS180i, HIS222c, HIS222i, HIS251c, HIS251i, LYS230c, LYS233c, LYS233i, SER201i
• c-k: GLY32c, GLY32k, VAL34c, VAL34k
• d-e: ALA57d, ARG10e, ARG7e, ASN46d, ASP94d, GLU73e, GLU74e, GLY55d, ILE43d, LEU8e, LYS21d, LYS96e, SER12e, TYR45d
• d-g: ASP221d, ASP221g, ASP223g, GLU31d, GLY187d, GLY187g, HIS180d, HIS180g, HIS222d, HIS222g, HIS251d, HIS251g, LYS230d, LYS230g, LYS233d, LYS233g, MET199d, SER201g
• d-h: GLY32d, GLY32h, VAL34d, VAL34h
• e-h: ASP221e, ASP221h, GLY187e, GLY187h, HIS180e, HIS180h, HIS222e, HIS222h, HIS251e, HIS251h, LYS230e, LYS233e, LYS233h, SER201h
• e-i: GLY32e, GLY32i, VAL34e, VAL34i
• g-h: ALA57h, ARG10g, ARG35h, ARG7g, ASN46h, ASP94h, GLU73g, GLU74g, ILE43h, LEU8g, LYS140g, LYS21h, LYS96g, SER12g, TYR226g, TYR26h, TYR45h
• g-j: ALA57g, ARG10j, ARG7j, ASN46g, ASP94g, GLU73j, GLU74j, ILE43g, LEU8j, LYS21g, LYS96j, SER12j, SER189j, TYR26g, TYR45g
• h-i: ALA57i, ARG10h, ARG7h, ASN46i, ASP94i, GLU73h, GLU74h, ILE43i, LEU8h, LYS21i, LYS96h, SER12h, TYR226h, TYR26i, TYR45i
• i-k: ALA57k, ARG10i, ARG7i, ASN46k, ASP94k, GLU73i, GLU74i, ILE43k, LEU8i, LYS21k, LYS96i, SER12i, SER189i, TYR226i, TYR26k, TYR45k
• j-k: ALA57j, ARG10k, ARG7k, ASN46j, ASP94j, GLU73k, GLU74k, ILE43j, LEU8k, LYS21j, LYS96k, SER12k, SER189k, TYR26j, TYR45j