3N93

crystal structure of human crfr2 alpha extracellular domain in complex with urocortin 3

• Total interactions analyzed: 3
• Total true interactions: 2
• Strongest Interaction:
  • Chains: B-C
  • Int. Res.: 67
  • Norm. En. per Res.: -2.7081
• Hub Node: A(1)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-14.7207	61.7391	-356.342	-309.3236	180	8	20	15096	1	29	37
B-C	-19.2567	-22.2549	-139.931	-181.4425	67	5	8	6596	1	6	4

Interface residues

• A-B: 1.00585CB6.9310, 5LYSCBLYS-195B, ALA-101A, ALA-182B, ALA-184B, ALA-1A, ALA-1B, ALA-202B, ALA-28A, ALA-2A, ALA-32A, ALA-6A, ALA0A, ALA0B, ALA12A, ALA12B, ALA17A, ALA17B, ALA19A, ALA19B, ALA3A, ALA3B, ALA4A, ALA4B, ALA55B, ALA56A, ALA56B, ALA58B, ALA90A, ALA90B, ARG-272B, ARG53A, ARG53B, ARG81B, ASN-185B, ASN-197A, ASN-197B, ASN-270A, ASN-3A, ASN-3B, ASN13A, ASN13B, ASN41A, ASN41B, ASN86A, ASN86B, ASP-12B, ASP-186B, ASP-190A, ASP-190B, ASP-193A, ASP-193B, ASP-315A, ASP-7A, ASP-7B, ASP25A, ASP25B, ASP32A, CYS14A, CYS14B, CYS40A, CYS40B, CYS83B, GLN-298A, GLN-35A, GLN-5A, GLN-5B, GLU-11B, GLU-198B, GLU-366A, GLU11A, GLU11B, GLU1A, GLU1B, GLU20A, GLU20B, GLU21A, GLU21B, GLU34A, GLU85A, GLU85B, GLY-183B, GLY-188B, GLY-196B, GLY-204B, GLY-269B, GLY-301A, GLY-302A, GLY-316A, GLY26A, GLY28A, GLY35A, GLY57B, GLY87A, GLY87B, HIS7A, HIS7B, ILE-192A, ILE-368A, ILE-37A, LEU-9A, LEU-9B, LEU10A, LEU10B, LEU16A, LEU16B, LEU18A, LEU18B, LEU22A, LEU22B, LEU23A, LEU23B, LEU24A, LEU24B, LEU31A, LEU44A, LEU44B, LEU5A, LEU5B, LEU6A, LEU6B, LEU84A, LEU84B, LEU9A, LEU9B, LYS-181B, LYS-191A, LYS-191B, LYS-195A, LYS-195B, LYS-200B, LYS-369A, LYS-8A, LYS-8B, MET-34A, PHE-201A, PHE-31A, PHE2A, PHE2B, PRO-36A, PRO-99A, PRO29A, PRO30A, PRO33A, PRO36B, SER-33A, SER15A, SER15B, SER38A, SER38B, SER8A, SER8B, SER91A, SER91B, THR-317A, THR-4A, THR-4B, THR42A, THR42B, THR43A, THR88A, THR88B, TRP-30A, TRP27A, TRP89A, TRP89B, TYR-194A, TYR-199B, TYR-203B, TYR-271A, TYR-29A, TYR37A, TYR37B, TYR39A, TYR39B, VAL-187A, VAL-187B, VAL-189A, VAL-189B, VAL-27A
• B-C: ALA-299B, ALA-318B, ALA-319B, ALA-32B, ALA29C, ALA31C, ALA32C, ALA33C, ALA35C, ALA39C, ALA79B, ALA90B, ARG28C, ARG81B, ASN26C, ASN34C, ASN69B, ASN94B, ASP103B, ASP45B, CYS64B, CYS98B, GLN-298B, GLN-321B, GLN30C, GLN40C, GLN46B, GLN97B, GLU-325B, GLU99B, GLY-296B, GLY-301B, GLY-316B, GLY48B, GLY70B, HIS36C, ILE101B, ILE41C, ILE47B, ILE93B, LEU-295B, LEU102B, LEU27C, LEU37C, LYS-324B, LYS-328B, LYS72B, LYS92B, MET38C, PHE68B, PRO-322B, PRO100B, PRO65B, SER-297B, SER-33B, SER91B, SER96B, THR-317B, THR49B, TRP51B, TYR-29B, TYR-300B, TYR67B, TYR73B, TYR95B, VAL-320B, VAL71B