3N6R

crystal structure of the holoenzyme of propionyl-coa carboxylase (pcc)

• Total interactions analyzed: 66
• Total true interactions: 32
• Strongest Interaction:
  • Chains: B-L
  • Int. Res.: 26
  • Norm. En. per Res.: -5.3355
• Hub Node: B(7)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-106.1023	-82.6214	-497.39	-686.1137	206	40	7	20769	14	124	104
A-D	0.0	-49.288	-55.741	-105.029	31	7	0	2215	5	17	20
A-J	0.0	0.0	-2.2876	-2.2876	10	0	0	236	0	0	0
B-D	-47.1034	-14.8656	-246.407	-308.376	101	19	2	10238	3	40	41
B-E	0.0	-46.2858	-53.1032	-99.389	32	3	0	2072	5	17	19
B-F	-45.4524	-12.7884	-240.917	-299.1577	100	20	2	10165	4	40	42
B-H	0.0	0.0	-0.0158	-0.0158	6	0	0	20	0	0	0
B-I	0.0	0.0	-2.688	-2.688	11	0	0	268	0	0	0
B-J	-180.7686	-283.5494	-1413.53	-1877.848	420	116	60	60380	22	110	125
B-L	-20.9047	-95.6066	-22.2119	-138.7233	26	10	0	1241	6	21	14
C-D	-110.2701	-124.133	-476.014	-710.4171	206	39	7	20340	13	122	102
C-F	0.0	-46.2385	-56.5516	-102.7901	30	5	0	2107	5	17	19
C-L	0.0	0.0	-2.729	-2.729	11	0	0	263	0	0	0
D-F	-48.6155	-14.0529	-239.109	-301.7774	102	18	2	10090	2	40	42
D-H	-20.8947	-100.5349	-13.7644	-135.194	26	11	0	1238	6	19	14
D-J	0.0	0.0	-0.0152	-0.0152	8	0	0	19	0	0	0
D-K	0.0	0.0	-2.5859	-2.5859	11	0	0	253	0	0	0
D-L	-204.2811	-269.3025	-546.443	-1020.0266	222	34	29	23910	2	37	32
E-F	-104.3744	-76.4157	-468.365	-649.1551	207	34	7	20432	13	122	104
E-H	0.0	0.0	-2.7358	-2.7358	12	0	0	269	0	0	0
F-G	0.0	0.0	-2.5625	-2.5625	10	0	0	247	0	0	0
F-H	-210.2115	-290.1382	-1403.41	-1903.7597	418	115	60	60529	24	110	125
F-J	-20.7146	-102.1295	-14.913	-137.7571	26	10	0	1261	6	20	14
G-H	-104.9662	-85.7825	-477.097	-667.8457	205	42	7	20536	14	122	104
G-L	0.0	-48.5099	-8.1162	-56.6261	15	0	0	362	0	8	7
H-I	0.0	-46.9732	-57.5917	-104.5649	31	5	0	2143	5	17	19
H-J	-48.4859	-16.2344	-255.522	-320.2423	99	22	2	10291	4	40	42
H-L	-49.5726	-16.6471	-0.1412	-66.3609	27	0	0	27	0	0	5
I-J	-125.6348	-83.7628	-459.616	-669.0136	207	34	7	20428	14	124	102
J-K	0.0	-44.5074	-58.0179	-102.5254	30	5	0	2150	5	17	20
J-L	-48.4973	-13.1768	-251.234	-312.9081	103	21	2	10311	3	40	42
K-L	-114.1511	-80.7283	-430.298	-625.1775	178	45	5	18615	14	115	91

Interface residues

• A-B: ALA267B, ALA269B, ALA324B, ALA363B, ALA536A, ALA644A, ALA647A, ALA692A, ALA96A, ARG117B, ARG252B, ARG272B, ARG273B, ARG289B, ARG297B, ARG346B, ARG416A, ARG419A, ARG432B, ARG509B, ARG539A, ARG540A, ARG542A, ARG546A, ARG553A, ARG554A, ARG61B, ARG639A, ARG642A, ARG648A, ARG67B, ARG69B, ARG700A, ASN115B, ASN263B, ASN309B, ASN311B, ASN339B, ASN697A, ASP219B, ASP264B, ASP276B, ASP293B, ASP303B, ASP308B, ASP315B, ASP325B, ASP328B, ASP367B, ASP393B, ASP548A, ASP56B, ASP600A, ASP71B, ASP75B, CYS365B, GLN358B, GLN58B, GLN601A, GLN643A, GLN99A, GLU262B, GLU266B, GLU270B, GLU284B, GLU299B, GLU318B, GLU326B, GLU437A, GLU440A, GLU476A, GLU537A, GLU552A, GLU558A, GLU645A, GLU652A, GLU68B, GLU691A, GLU696A, GLU76B, GLY112B, GLY116B, GLY327B, GLY349B, GLY364B, GLY438A, GLY439A, GLY467B, GLY477A, GLY545A, GLY556A, GLY599A, GLY60B, GLY623A, GLY624A, GLY62B, GLY77B, HIS321B, HIS551A, HIS59B, HIS637A, ILE114B, ILE298B, ILE538A, ILE55B, ILE619A, ILE698A, LEU268B, LEU274B, LEU278B, LEU280B, LEU302B, LEU305B, LEU319B, LEU360B, LEU362B, LEU366B, LEU398B, LEU417A, LEU646A, LEU649A, LEU64B, LEU654A, LEU72B, LEU73B, LEU74B, LYS218B, LYS285B, LYS322B, LYS433B, LYS466B, LYS618A, LYS635A, LYS63B, LYS653A, LYS694A, LYS98A, MET197B, MET547A, MET650A, MET666A, MET693A, MET695A, PHE261B, PHE277B, PHE291B, PHE292B, PHE329B, PHE397B, PHE79B, PRO279B, PRO286B, PRO287B, PRO290B, PRO300B, PRO307B, PRO310B, PRO313B, PRO359B, PRO395B, PRO399B, PRO598A, PRO641A, PRO651A, PRO655A, PRO656A, PRO665A, PRO667A, SER220B, SER301B, SER544A, SER620A, SER78B, THR113B, THR304B, THR312B, THR418A, THR541A, THR557A, THR597A, THR640A, THR65B, THR689A, TRP111B, TRP455B, TRP559A, TRP596A, TYR314B, TYR330B, TYR420A, TYR436A, VAL118B, VAL119B, VAL217B, VAL265B, VAL271B, VAL275B, VAL288B, VAL306B, VAL361B, VAL394B, VAL535A, VAL543A, VAL555A, VAL671A, VAL70B
• A-D: ALA516D, ALA518D, ALA520D, ARG289D, ARG350D, ARG512D, ARG514D, ARG517D, ARG523D, ARG546A, ARG554A, ASN524D, ASN550A, ASP293D, ASP294D, ASP296D, ASP325D, ASP548A, GLU348D, GLY349D, HIS551A, LEU347D, LEU522D, LYS513D, MET547A, PHE291D, PHE519D, PRO295D, SER521D, VAL288D, VAL515D
• A-J: ALA692A, ASN236J, GLY668A, LYS694A, MET693A, PRO667A, SER717A, THR233J, THR235J, VAL234J
• B-D: ALA103B, ALA148B, ALA153B, ALA449D, ALA454D, ALA458D, ALA496D, ALA516D, ALA518D, ALA520D, ARG283B, ARG42B, ARG43B, ARG448D, ARG47B, ARG499D, ARG509D, ARG514D, ARG517D, ARG523D, ARG89B, ASN151B, ASN281B, ASN452D, ASN492D, ASN524D, ASP105B, ASP146B, ASP303D, ASP450D, ASP503D, ASP83B, GLN150B, GLN38B, GLN507D, GLN528D, GLU135B, GLU284B, GLU37B, GLU40B, GLU498D, GLU504D, GLU80B, GLU81B, GLY104B, GLY110B, GLY112B, GLY152B, GLY500D, GLY77B, HIS88B, ILE506D, LEU280B, LEU36B, LEU39B, LEU522D, LYS101B, LYS139B, LYS140B, LYS143B, LYS445D, LYS513D, LYS525D, MET147B, MET149B, MET84B, PHE451D, PHE494D, PHE501D, PHE519D, PHE79B, PHE82B, PHE85B, PRO102B, PRO425D, PRO456D, PRO493D, PRO508D, SER497D, SER510D, SER521D, SER526D, SER78B, THR113B, THR136B, THR423D, THR457D, THR87B, TRP111B, TRP455D, TYR120B, TYR453D, VAL118B, VAL119B, VAL190B, VAL495D, VAL502D, VAL505D, VAL515D, VAL527D, VAL86B
• B-E: ALA516B, ALA518B, ALA520B, ARG289B, ARG350B, ARG512B, ARG514B, ARG517B, ARG523B, ARG546E, ARG554E, ASN524B, ASN550E, ASP293B, ASP294B, ASP296B, ASP325B, ASP548E, GLU348B, GLY349B, HIS551E, LEU347B, LEU522B, LYS513B, MET547E, PHE291B, PHE519B, PRO290B, PRO295B, SER521B, VAL288B, VAL515B
• B-F: ALA103F, ALA148F, ALA153F, ALA449B, ALA454B, ALA496B, ALA516B, ALA518B, ALA520B, ARG283F, ARG42F, ARG43F, ARG448B, ARG47F, ARG499B, ARG509B, ARG514B, ARG517B, ARG523B, ARG89F, ASN151F, ASN281F, ASN452B, ASN492B, ASN524B, ASP105F, ASP146F, ASP303B, ASP450B, ASP503B, ASP83F, GLN150F, GLN38F, GLN507B, GLN528B, GLU135F, GLU284F, GLU37F, GLU40F, GLU498B, GLU504B, GLU80F, GLU81F, GLY104F, GLY110F, GLY112F, GLY152F, GLY500B, GLY77F, HIS88F, ILE506B, LEU280F, LEU36F, LEU39F, LEU522B, LYS101F, LYS139F, LYS140F, LYS143F, LYS445B, LYS513B, LYS525B, MET147F, MET149F, MET84F, PHE451B, PHE494B, PHE501B, PHE519B, PHE79F, PHE82F, PHE85F, PRO102F, PRO425B, PRO456B, PRO493B, PRO508B, SER497B, SER510B, SER521B, SER526B, SER78F, THR113F, THR136F, THR423B, THR457B, THR87F, TRP111F, TRP455B, TYR120F, TYR453B, VAL118F, VAL119F, VAL190F, VAL495B, VAL502B, VAL505B, VAL515B, VAL527B, VAL86F
• B-H: GLN528B, GLN528H, PRO530B, PRO530H, TRP531B, TRP531H
• B-I: ALA692I, ASN236B, GLY668I, LEU669I, LYS694I, MET693I, PRO667I, SER717I, THR233B, THR235B, VAL234B
• B-J: ALA164B, ALA164J, ALA174B, ALA174J, ALA186B, ALA186J, ALA201B, ALA201J, ALA204B, ALA204J, ALA209B, ALA209J, ALA241B, ALA241J, ALA257B, ALA257J, ALA374B, ALA374J, ALA375B, ALA375J, ALA383B, ALA383J, ALA413B, ALA413J, ALA418B, ALA418J, ALA422B, ALA422J, ALA434B, ALA434J, ALA438B, ALA438J, ALA449B, ALA449J, ALA461B, ALA461J, ALA468B, ALA468J, ALA496B, ALA496J, ARG165B, ARG165J, ARG182B, ARG182J, ARG283B, ARG283J, ARG372B, ARG372J, ARG376B, ARG376J, ARG379B, ARG379J, ARG448B, ARG448J, ARG474B, ARG474J, ARG489B, ARG489J, ARG499B, ARG499J, ARG89B, ARG89J, ASN183B, ASN183J, ASN236B, ASN236J, ASN281B, ASN281J, ASN282B, ASN282J, ASN492B, ASN492J, ASN536B, ASN536J, ASN94B, ASN94J, ASP146B, ASP146J, ASP171B, ASP171J, ASP212B, ASP212J, ASP229B, ASP229J, ASP258B, ASP258J, ASP367B, ASP367J, ASP369B, ASP369J, ASP382B, ASP382J, ASP485B, ASP485J, ASP535B, ASP535J, ASP92B, ASP92J, CYS142J, CYS200B, CYS200J, CYS365B, CYS365J, CYS381B, CYS381J, CYS90B, CYS90J, GLN167B, GLN167J, GLN181B, GLN181J, GLN192B, GLN192J, GLN238B, GLN238J, GLN333B, GLN333J, GLN403B, GLN403J, GLN528B, GLN528J, GLN98J, GLU135B, GLU135J, GLU168B, GLU168J, GLU178B, GLU178J, GLU237B, GLU237J, GLU242B, GLU242J, GLU243B, GLU243J, GLU284B, GLU284J, GLU385B, GLU385J, GLU404B, GLU404J, GLU421B, GLU421J, GLU459B, GLU459J, GLU470B, GLU470J, GLU498B, GLU498J, GLY169B, GLY169J, GLY175B, GLY175J, GLY177B, GLY177J, GLY188B, GLY188J, GLY202B, GLY202J, GLY203B, GLY203J, GLY227B, GLY227J, GLY245B, GLY245J, GLY246B, GLY246J, GLY396B, GLY396J, GLY400B, GLY400J, GLY406B, GLY406J, GLY407B, GLY407J, GLY412B, GLY412J, GLY420B, GLY420J, GLY436B, GLY436J, GLY437B, GLY437J, GLY464B, GLY464J, GLY467B, GLY467J, GLY500B, GLY500J, HIS250B, HIS250J, HIS411B, HIS411J, HIS446B, HIS446J, HIS473B, HIS473J, HIS482B, HIS482J, HIS534B, HIS534J, ILE166B, ILE166J, ILE184B, ILE184J, ILE196B, ILE196J, ILE214B, ILE214J, ILE368B, ILE368J, ILE386B, ILE386J, ILE409B, ILE409J, ILE471B, ILE471J, ILE472B, ILE472J, ILE537B, ILE537J, LEU173B, LEU173J, LEU244B, LEU244J, LEU366B, LEU366J, LEU388B, LEU388J, LEU398B, LEU398J, LEU415B, LEU415J, LEU416B, LEU416J, LEU447B, LEU447J, LEU539B, LEU539J, LYS232B, LYS232J, LYS253B, LYS253J, LYS285B, LYS285J, LYS373B, LYS373J, LYS410B, LYS410J, LYS414B, LYS414J, LYS445B, LYS445J, LYS525B, LYS525J, LYS532B, LYS532J, LYS533B, LYS533J, MET149B, MET149J, MET185B, MET185J, MET210B, MET210J, MET216B, MET216J, MET223B, MET223J, MET426B, MET426J, MET463B, MET463J, MET529B, MET529J, MET95B, MET95J, PHE180B, PHE180J, PHE213B, PHE213J, PHE224B, PHE224J, PHE336B, PHE336J, PHE377B, PHE377J, PHE380B, PHE380J, PHE384B, PHE384J, PHE397B, PHE397J, PHE490B, PHE490J, PHE494B, PHE494J, PHE501B, PHE501J, PHE93B, PHE93J, PRO191B, PRO208B, PRO208J, PRO228B, PRO228J, PRO387J, PRO399B, PRO399J, PRO425B, PRO425J, PRO493B, PRO493J, PRO530B, PRO530J, PRO538B, PRO538J, SER172B, SER172J, SER187B, SER187J, SER207B, SER207J, SER240B, SER240J, SER254B, SER254J, SER255B, SER255J, SER371B, SER371J, SER402B, SER402J, SER444B, SER444J, SER497B, SER497J, SER526B, SER526J, THR211B, THR211J, THR226B, THR226J, THR233B, THR233J, THR235B, THR235J, THR249B, THR249J, THR401B, THR401J, THR423B, THR423J, THR469B, THR469J, THR91B, THR91J, TRP531B, TRP531J, TYR176B, TYR176J, TYR206B, TYR206J, TYR222B, TYR222J, TYR405B, TYR405J, TYR417B, TYR417J, TYR419B, TYR419J, TYR435B, TYR435J, TYR439B, TYR439J, TYR486B, TYR486J, VAL133B, VAL133J, VAL170B, VAL170J, VAL179B, VAL179J, VAL189B, VAL189J, VAL190B, VAL190J, VAL205B, VAL205J, VAL225B, VAL225J, VAL230B, VAL230J, VAL231B, VAL231J, VAL234B, VAL234J, VAL239B, VAL239J, VAL256B, VAL256J, VAL378B, VAL378J, VAL408B, VAL408J, VAL424B, VAL424J, VAL440B, VAL440J, VAL441B, VAL441J, VAL460B, VAL460J, VAL462B, VAL462J, VAL495B, VAL495J, VAL502B, VAL502J, VAL527B, VAL527J
• B-L: ARG89B, ARG89L, ASP171B, ASP171L, CYS90B, CYS90L, GLN98B, GLN98L, GLU135B, GLU135L, GLU168B, GLU168L, GLU178B, GLU178L, HIS88B, HIS88L, LYS101B, LYS101L, LYS139B, LYS139L, THR136B, THR136L, THR91B, THR91L, VAL170B, VAL170L
• C-D: ALA267D, ALA269D, ALA324D, ALA363D, ALA536C, ALA644C, ALA647C, ALA692C, ALA96C, ARG117D, ARG252D, ARG272D, ARG273D, ARG289D, ARG297D, ARG346D, ARG350D, ARG416C, ARG419C, ARG432D, ARG539C, ARG540C, ARG542C, ARG546C, ARG553C, ARG554C, ARG61D, ARG639C, ARG642C, ARG648C, ARG67D, ARG69D, ARG700C, ASN115D, ASN263D, ASN309D, ASN311D, ASN339D, ASN697C, ASP219D, ASP264D, ASP276D, ASP293D, ASP303D, ASP308D, ASP315D, ASP325D, ASP328D, ASP367D, ASP393D, ASP548C, ASP56D, ASP595C, ASP600C, ASP71D, ASP75D, CYS365D, GLN358D, GLN58D, GLN601C, GLN643C, GLN99C, GLU262D, GLU266D, GLU270D, GLU284D, GLU299D, GLU318D, GLU326D, GLU437C, GLU440C, GLU476C, GLU537C, GLU552C, GLU558C, GLU645C, GLU652C, GLU68D, GLU691C, GLU696C, GLU76D, GLY112D, GLY116D, GLY327D, GLY349D, GLY364D, GLY438C, GLY439C, GLY545C, GLY556C, GLY599C, GLY60D, GLY623C, GLY624C, GLY62D, GLY77D, HIS321D, HIS533C, HIS551C, HIS59D, HIS637C, ILE114D, ILE298D, ILE538C, ILE55D, ILE619C, ILE698C, LEU268D, LEU274D, LEU278D, LEU280D, LEU302D, LEU305D, LEU319D, LEU360D, LEU362D, LEU366D, LEU398D, LEU417C, LEU646C, LEU649C, LEU64D, LEU654C, LEU72D, LEU73D, LEU74D, LYS218D, LYS285D, LYS322D, LYS433D, LYS466D, LYS618C, LYS635C, LYS63D, LYS653C, LYS694C, LYS98C, MET197D, MET547C, MET650C, MET666C, MET693C, MET695C, PHE261D, PHE277D, PHE291D, PHE292D, PHE329D, PHE397D, PHE79D, PRO279D, PRO286D, PRO287D, PRO290D, PRO300D, PRO307D, PRO310D, PRO313D, PRO359D, PRO395D, PRO399D, PRO598C, PRO641C, PRO651C, PRO655C, PRO656C, PRO665C, PRO667C, SER220D, SER301D, SER544C, SER620C, SER78D, THR113D, THR304D, THR312D, THR418C, THR541C, THR557C, THR597C, THR640C, THR65D, THR689C, TRP111D, TRP455D, TRP559C, TRP596C, TYR314D, TYR330D, TYR420C, TYR436C, VAL118D, VAL119D, VAL217D, VAL265D, VAL271D, VAL275D, VAL288D, VAL306D, VAL361D, VAL394D, VAL535C, VAL543C, VAL555C, VAL671C, VAL70D
• C-F: ALA516F, ALA518F, ALA520F, ARG289F, ARG350F, ARG512F, ARG514F, ARG517F, ARG523F, ARG546C, ARG554C, ASN524F, ASN550C, ASP294F, ASP296F, ASP325F, ASP548C, GLU348F, GLY349F, HIS551C, LEU347F, LEU522F, LYS513F, MET547C, PHE291F, PHE519F, PRO295F, SER521F, VAL288F, VAL515F
• C-L: ALA692C, ASN236L, GLY668C, LEU669C, LYS694C, MET693C, PRO667C, SER717C, THR233L, THR235L, VAL234L
• D-F: ALA103D, ALA148D, ALA153D, ALA449F, ALA454F, ALA458F, ALA496F, ALA516F, ALA518F, ALA520F, ARG283D, ARG42D, ARG43D, ARG448F, ARG47D, ARG499F, ARG509F, ARG514F, ARG517F, ARG523F, ARG89D, ASN151D, ASN281D, ASN452F, ASN492F, ASN524F, ASP105D, ASP146D, ASP303F, ASP450F, ASP503F, ASP83D, GLN150D, GLN38D, GLN507F, GLN528F, GLU135D, GLU284D, GLU37D, GLU40D, GLU498F, GLU504F, GLU80D, GLU81D, GLY104D, GLY110D, GLY112D, GLY152D, GLY500F, GLY77D, HIS88D, ILE506F, LEU280D, LEU36D, LEU39D, LEU522F, LYS101D, LYS139D, LYS140D, LYS143D, LYS285F, LYS445F, LYS513F, LYS525F, MET147D, MET149D, MET84D, PHE451F, PHE494F, PHE501F, PHE519F, PHE79D, PHE82D, PHE85D, PRO102D, PRO425F, PRO456F, PRO493F, PRO508F, SER497F, SER510F, SER521F, SER526F, SER78D, THR113D, THR136D, THR423F, THR457F, THR87D, TRP111D, TRP455F, TYR120D, TYR453F, VAL118D, VAL119D, VAL190D, VAL495F, VAL502F, VAL505F, VAL515F, VAL527F, VAL86D
• D-H: ARG89D, ARG89H, ASP171D, ASP171H, CYS90D, CYS90H, GLN98D, GLN98H, GLU135D, GLU135H, GLU168D, GLU168H, GLU178D, GLU178H, HIS88D, HIS88H, LYS101D, LYS101H, LYS139D, LYS139H, THR136D, THR136H, THR91D, THR91H, VAL170D, VAL170H
• D-J: ARG448D, ARG448J, GLN528D, GLN528J, PRO530D, PRO530J, TRP531D, TRP531J
• D-K: ALA692K, ASN236D, GLY668K, LEU669K, LYS694K, MET693K, PRO667K, SER717K, THR233D, THR235D, VAL234D
• D-L: ALA164L, ALA174L, ALA186L, ALA201L, ALA204L, ALA209L, ALA241L, ALA257L, ALA413D, ALA418D, ALA422D, ALA434D, ALA438D, ALA449D, ALA461D, ALA468D, ALA496D, ARG165L, ARG182L, ARG283L, ARG372D, ARG372L, ARG376D, ARG376L, ARG379D, ARG379L, ARG448D, ARG448L, ARG474D, ARG489D, ARG489L, ARG499D, ARG499L, ARG89L, ASN183L, ASN236L, ASN281L, ASN282D, ASN282L, ASN492D, ASN536D, ASN536L, ASN94L, ASP146L, ASP171D, ASP171L, ASP212L, ASP229D, ASP229L, ASP258L, ASP367D, ASP382D, ASP382L, ASP485D, ASP535D, ASP535L, ASP92D, ASP92L, CYS200L, CYS365D, CYS90L, GLN167L, GLN181L, GLN192L, GLN238L, GLN403D, GLN528D, GLU135D, GLU135L, GLU168L, GLU178D, GLU178L, GLU237L, GLU242L, GLU243L, GLU284L, GLU385D, GLU385L, GLU404D, GLU404L, GLU421D, GLU421L, GLU459D, GLU470D, GLU470L, GLU498D, GLY169L, GLY175L, GLY177L, GLY188L, GLY202L, GLY203L, GLY227L, GLY245L, GLY246L, GLY396D, GLY400D, GLY406D, GLY407D, GLY412D, GLY420D, GLY436D, GLY437D, GLY464D, GLY467D, GLY500D, HIS250D, HIS250L, HIS411D, HIS446D, HIS446L, HIS473D, HIS482D, HIS534D, HIS534L, ILE166L, ILE184L, ILE196L, ILE214L, ILE368D, ILE409D, ILE471D, ILE472D, ILE537D, LEU173L, LEU244L, LEU366D, LEU398D, LEU415D, LEU416D, LEU447D, LEU539D, LEU539L, LYS232L, LYS253L, LYS285L, LYS410D, LYS410L, LYS414D, LYS414L, LYS445D, LYS532D, LYS532L, LYS533D, LYS533L, MET149L, MET185D, MET185L, MET210L, MET216L, MET223L, MET426D, MET463D, MET529D, MET95L, PHE180L, PHE213L, PHE224L, PHE397D, PHE490D, PHE494D, PHE501D, PHE93L, PRO208L, PRO228L, PRO399D, PRO493D, PRO530D, PRO538D, SER172L, SER187D, SER187L, SER207L, SER240L, SER254L, SER255L, SER371D, SER402D, SER444D, SER497D, THR211L, THR226L, THR233L, THR235L, THR249L, THR401D, THR423D, THR423L, THR469D, THR91L, TRP531D, TRP531L, TYR176L, TYR206L, TYR222L, TYR405D, TYR417D, TYR419D, TYR435D, TYR439D, TYR486D, VAL133L, VAL170L, VAL179L, VAL189L, VAL190L, VAL205L, VAL225D, VAL225L, VAL230L, VAL231L, VAL234L, VAL239L, VAL256L, VAL408D, VAL440D, VAL441D, VAL460D, VAL462D, VAL495D, VAL502D, VAL527D
• E-F: ALA267F, ALA269F, ALA324F, ALA363F, ALA536E, ALA644E, ALA647E, ALA692E, ALA96E, ARG117F, ARG252F, ARG272F, ARG273F, ARG289F, ARG297F, ARG346F, ARG350F, ARG416E, ARG419E, ARG432F, ARG539E, ARG540E, ARG542E, ARG546E, ARG553E, ARG554E, ARG61F, ARG639E, ARG642E, ARG648E, ARG67F, ARG69F, ARG700E, ASN115F, ASN263F, ASN309F, ASN311F, ASN339F, ASN697E, ASP219F, ASP264F, ASP276F, ASP293F, ASP303F, ASP308F, ASP315F, ASP325F, ASP328F, ASP367F, ASP393F, ASP548E, ASP56F, ASP595E, ASP600E, ASP71F, ASP75F, CYS365F, GLN358F, GLN58F, GLN601E, GLN643E, GLN99E, GLU262F, GLU266F, GLU270F, GLU284F, GLU299F, GLU318F, GLU326F, GLU437E, GLU440E, GLU476E, GLU537E, GLU552E, GLU558E, GLU645E, GLU652E, GLU68F, GLU691E, GLU696E, GLU76F, GLY112F, GLY116F, GLY327F, GLY349F, GLY364F, GLY438E, GLY439E, GLY477E, GLY545E, GLY556E, GLY599E, GLY60F, GLY623E, GLY624E, GLY62F, GLY77F, HIS321F, HIS551E, HIS59F, HIS637E, ILE114F, ILE298F, ILE538E, ILE55F, ILE619E, ILE698E, LEU268F, LEU274F, LEU278F, LEU280F, LEU302F, LEU305F, LEU319F, LEU360F, LEU362F, LEU366F, LEU398F, LEU417E, LEU646E, LEU649E, LEU64F, LEU654E, LEU72F, LEU73F, LEU74F, LYS218F, LYS285F, LYS322F, LYS433F, LYS466F, LYS618E, LYS635E, LYS63F, LYS653E, LYS694E, LYS98E, MET197F, MET547E, MET650E, MET666E, MET693E, MET695E, PHE261F, PHE277F, PHE291F, PHE292F, PHE329F, PHE397F, PHE79F, PRO279F, PRO286F, PRO287F, PRO290F, PRO300F, PRO307F, PRO310F, PRO313F, PRO359F, PRO395F, PRO399F, PRO598E, PRO641E, PRO651E, PRO655E, PRO656E, PRO665E, PRO667E, SER220F, SER301F, SER544E, SER620E, SER78F, THR113F, THR248F, THR304F, THR312F, THR418E, THR541E, THR557E, THR597E, THR640E, THR65F, THR689E, TRP111F, TRP455F, TRP559E, TRP596E, TYR314F, TYR330F, TYR420E, TYR436E, VAL118F, VAL119F, VAL217F, VAL265F, VAL271F, VAL275F, VAL288F, VAL306F, VAL361F, VAL394F, VAL535E, VAL543E, VAL555E, VAL671E, VAL70F
• E-H: ALA692E, ASN236H, GLY668E, LEU669E, LYS694E, MET693E, PRO667E, SER717E, THR233H, THR235H, VAL230H, VAL234H
• F-G: ALA692G, ASN236F, GLY668G, LYS694G, MET693G, PRO667G, SER717G, THR233F, THR235F, VAL234F
• F-H: ALA164F, ALA164H, ALA174F, ALA174H, ALA186F, ALA186H, ALA201F, ALA201H, ALA204F, ALA204H, ALA209F, ALA209H, ALA241F, ALA241H, ALA257F, ALA257H, ALA374F, ALA374H, ALA375F, ALA375H, ALA383F, ALA383H, ALA413F, ALA413H, ALA418F, ALA418H, ALA422F, ALA422H, ALA434F, ALA434H, ALA438F, ALA438H, ALA449F, ALA449H, ALA461F, ALA461H, ALA468F, ALA468H, ALA496F, ALA496H, ARG165F, ARG165H, ARG182F, ARG182H, ARG283F, ARG283H, ARG372F, ARG372H, ARG376F, ARG376H, ARG379F, ARG379H, ARG448F, ARG448H, ARG474F, ARG474H, ARG489F, ARG489H, ARG499F, ARG499H, ARG89F, ARG89H, ASN183F, ASN183H, ASN236F, ASN236H, ASN281F, ASN281H, ASN282F, ASN282H, ASN492F, ASN492H, ASN536F, ASN536H, ASN94F, ASN94H, ASP146F, ASP146H, ASP171F, ASP171H, ASP212F, ASP212H, ASP229F, ASP229H, ASP258F, ASP258H, ASP367F, ASP367H, ASP369F, ASP369H, ASP382F, ASP382H, ASP485F, ASP485H, ASP535F, ASP535H, ASP92F, ASP92H, CYS142F, CYS200F, CYS200H, CYS365F, CYS365H, CYS381F, CYS381H, CYS90F, CYS90H, GLN167F, GLN167H, GLN181F, GLN181H, GLN192F, GLN192H, GLN238F, GLN238H, GLN333F, GLN333H, GLN403F, GLN403H, GLN528F, GLN528H, GLU135F, GLU135H, GLU168F, GLU168H, GLU178F, GLU178H, GLU237F, GLU237H, GLU242F, GLU242H, GLU243F, GLU243H, GLU284F, GLU284H, GLU385F, GLU385H, GLU404F, GLU404H, GLU421F, GLU421H, GLU459F, GLU459H, GLU470F, GLU470H, GLU498F, GLU498H, GLY169F, GLY169H, GLY175F, GLY175H, GLY177F, GLY177H, GLY188F, GLY188H, GLY202F, GLY202H, GLY203F, GLY203H, GLY227F, GLY227H, GLY245F, GLY245H, GLY246F, GLY246H, GLY396F, GLY396H, GLY400F, GLY400H, GLY406F, GLY406H, GLY407F, GLY407H, GLY412F, GLY412H, GLY420F, GLY420H, GLY436F, GLY436H, GLY437F, GLY437H, GLY464F, GLY464H, GLY467F, GLY467H, GLY500F, GLY500H, HIS250F, HIS250H, HIS411F, HIS411H, HIS446F, HIS446H, HIS473F, HIS473H, HIS482F, HIS482H, HIS534F, HIS534H, ILE166F, ILE166H, ILE184F, ILE184H, ILE196F, ILE196H, ILE214F, ILE214H, ILE368F, ILE368H, ILE386F, ILE386H, ILE409F, ILE409H, ILE471F, ILE471H, ILE472F, ILE472H, ILE537F, ILE537H, LEU173F, LEU173H, LEU244F, LEU244H, LEU366F, LEU366H, LEU388F, LEU388H, LEU398F, LEU398H, LEU415F, LEU415H, LEU416F, LEU416H, LEU447F, LEU447H, LEU539F, LEU539H, LYS232F, LYS232H, LYS253F, LYS253H, LYS285F, LYS285H, LYS373F, LYS373H, LYS410F, LYS410H, LYS414F, LYS414H, LYS445F, LYS445H, LYS525F, LYS525H, LYS532F, LYS532H, LYS533F, LYS533H, MET149F, MET149H, MET185F, MET185H, MET210F, MET210H, MET216F, MET216H, MET223F, MET223H, MET426F, MET426H, MET463F, MET463H, MET529F, MET529H, MET95F, MET95H, PHE180F, PHE180H, PHE213F, PHE213H, PHE224F, PHE224H, PHE336F, PHE336H, PHE377F, PHE377H, PHE380F, PHE380H, PHE384F, PHE384H, PHE397F, PHE397H, PHE490F, PHE490H, PHE494F, PHE494H, PHE501F, PHE501H, PHE93F, PHE93H, PRO208F, PRO208H, PRO228F, PRO228H, PRO387F, PRO399F, PRO399H, PRO425F, PRO425H, PRO493F, PRO493H, PRO530F, PRO530H, PRO538F, PRO538H, SER172F, SER172H, SER187F, SER187H, SER207F, SER207H, SER240F, SER240H, SER254F, SER254H, SER255F, SER255H, SER371F, SER371H, SER402F, SER402H, SER444F, SER444H, SER497F, SER497H, SER526F, SER526H, THR211F, THR211H, THR226F, THR226H, THR233F, THR233H, THR235F, THR235H, THR249F, THR249H, THR401F, THR401H, THR423F, THR423H, THR469F, THR469H, THR91F, THR91H, TRP531F, TRP531H, TYR176F, TYR176H, TYR206F, TYR206H, TYR222F, TYR222H, TYR405F, TYR405H, TYR417F, TYR417H, TYR419F, TYR419H, TYR435F, TYR435H, TYR439F, TYR439H, TYR486F, TYR486H, VAL133F, VAL133H, VAL170F, VAL170H, VAL179F, VAL179H, VAL189F, VAL189H, VAL190F, VAL190H, VAL205F, VAL205H, VAL225F, VAL225H, VAL230F, VAL230H, VAL231F, VAL231H, VAL234F, VAL234H, VAL239F, VAL239H, VAL256F, VAL256H, VAL378F, VAL378H, VAL408F, VAL408H, VAL424F, VAL424H, VAL440F, VAL440H, VAL441F, VAL441H, VAL460F, VAL460H, VAL462F, VAL462H, VAL495F, VAL495H, VAL502F, VAL502H, VAL527F, VAL527H
• F-J: ARG89F, ARG89J, ASP171F, ASP171J, CYS90F, CYS90J, GLN98F, GLN98J, GLU135F, GLU135J, GLU168F, GLU168J, GLU178F, GLU178J, HIS88F, HIS88J, LYS101F, LYS101J, LYS139F, LYS139J, THR136F, THR136J, THR91F, THR91J, VAL170F, VAL170J
• G-H: ALA267H, ALA269H, ALA324H, ALA363H, ALA536G, ALA644G, ALA647G, ALA692G, ALA96G, ARG117H, ARG252H, ARG272H, ARG273H, ARG289H, ARG297H, ARG346H, ARG416G, ARG419G, ARG432H, ARG539G, ARG540G, ARG542G, ARG546G, ARG553G, ARG554G, ARG61H, ARG639G, ARG642G, ARG648G, ARG67H, ARG69H, ARG700G, ASN115H, ASN263H, ASN309H, ASN311H, ASN339H, ASN697G, ASP219H, ASP264H, ASP276H, ASP293H, ASP303H, ASP308H, ASP315H, ASP325H, ASP328H, ASP367H, ASP393H, ASP548G, ASP56H, ASP595G, ASP600G, ASP71H, ASP75H, CYS365H, GLN358H, GLN58H, GLN601G, GLN643G, GLN99G, GLU262H, GLU266H, GLU270H, GLU284H, GLU299H, GLU318H, GLU326H, GLU437G, GLU440G, GLU476G, GLU537G, GLU552G, GLU558G, GLU645G, GLU652G, GLU68H, GLU691G, GLU696G, GLU76H, GLY112H, GLY116H, GLY327H, GLY349H, GLY364H, GLY438G, GLY439G, GLY477G, GLY545G, GLY556G, GLY599G, GLY60H, GLY623G, GLY624G, GLY62H, GLY77H, HIS321H, HIS551G, HIS59H, HIS637G, ILE114H, ILE298H, ILE538G, ILE55H, ILE619G, ILE698G, LEU268H, LEU274H, LEU278H, LEU280H, LEU302H, LEU305H, LEU319H, LEU360H, LEU362H, LEU366H, LEU398H, LEU417G, LEU646G, LEU649G, LEU64H, LEU654G, LEU72H, LEU73H, LEU74H, LYS218H, LYS285H, LYS322H, LYS433H, LYS466H, LYS618G, LYS635G, LYS63H, LYS653G, LYS694G, LYS98G, MET197H, MET547G, MET650G, MET666G, MET693G, MET695G, PHE261H, PHE277H, PHE291H, PHE292H, PHE329H, PHE397H, PHE79H, PRO279H, PRO286H, PRO287H, PRO290H, PRO300H, PRO307H, PRO310H, PRO313H, PRO359H, PRO395H, PRO399H, PRO598G, PRO641G, PRO651G, PRO655G, PRO656G, PRO665G, PRO667G, SER220H, SER301H, SER544G, SER620G, SER78H, THR113H, THR304H, THR312H, THR418G, THR541G, THR557G, THR597G, THR640G, THR65H, THR689G, TRP111H, TRP455H, TRP559G, TRP596G, TYR314H, TYR330H, TYR420G, TYR436G, VAL118H, VAL119H, VAL217H, VAL265H, VAL271H, VAL275H, VAL288H, VAL306H, VAL361H, VAL394H, VAL535G, VAL543G, VAL555G, VAL671G, VAL70H
• G-L: ARG289L, ARG350L, ARG517L, ARG523L, ARG554G, ASN550G, ASP294L, ASP296L, ASP325L, ASP548G, GLU348L, HIS551G, PHE291L, PRO295L, VAL288L
• H-I: ALA516H, ALA518H, ALA520H, ARG289H, ARG350H, ARG512H, ARG514H, ARG517H, ARG523H, ARG546I, ARG554I, ASN524H, ASN550I, ASP294H, ASP296H, ASP325H, ASP548I, GLU348H, GLY349H, HIS551I, LEU347H, LEU522H, LYS513H, MET547I, PHE291H, PHE519H, PRO290H, PRO295H, SER521H, VAL288H, VAL515H
• H-J: ALA103J, ALA153J, ALA449H, ALA454H, ALA496H, ALA516H, ALA518H, ALA520H, ARG283J, ARG42J, ARG43J, ARG448H, ARG47J, ARG499H, ARG509H, ARG514H, ARG517H, ARG523H, ARG89J, ASN151J, ASN281J, ASN452H, ASN492H, ASN524H, ASP105J, ASP146J, ASP303H, ASP450H, ASP503H, ASP83J, GLN150J, GLN38J, GLN507H, GLN528H, GLU135J, GLU284J, GLU37J, GLU40J, GLU498H, GLU504H, GLU80J, GLU81J, GLY104J, GLY110J, GLY112J, GLY152J, GLY500H, GLY77J, HIS88J, ILE506H, LEU280J, LEU36J, LEU39J, LEU522H, LYS101J, LYS139J, LYS140J, LYS143J, LYS445H, LYS513H, LYS525H, MET147J, MET149J, MET84J, PHE451H, PHE494H, PHE501H, PHE519H, PHE79J, PHE82J, PHE85J, PRO102J, PRO425H, PRO456H, PRO493H, PRO508H, SER497H, SER510H, SER521H, SER526H, SER78J, THR113J, THR136J, THR423H, THR457H, THR87J, TRP111J, TRP455H, TYR120J, TYR453H, VAL118J, VAL119J, VAL190J, VAL495H, VAL502H, VAL505H, VAL515H, VAL527H, VAL86J
• H-L: ARG43H, ARG448L, ARG499L, ARG514L, ARG517L, ARG89H, ASN151H, ASP105H, ASP146H, ASP303L, ASP308L, ASP503L, ASP83H, GLN150H, GLU37H, GLU498L, GLU504L, GLU80H, GLU81H, GLY500L, HIS88H, LEU36H, LYS101H, LYS143H, LYS285L, LYS445L, SER526L
• I-J: ALA267J, ALA269J, ALA324J, ALA363J, ALA536I, ALA644I, ALA647I, ALA692I, ALA96I, ARG117J, ARG252J, ARG272J, ARG273J, ARG289J, ARG297J, ARG346J, ARG350J, ARG416I, ARG419I, ARG432J, ARG539I, ARG540I, ARG542I, ARG546I, ARG553I, ARG554I, ARG61J, ARG639I, ARG642I, ARG648I, ARG67J, ARG69J, ARG700I, ASN115J, ASN263J, ASN309J, ASN311J, ASN339J, ASN697I, ASP219J, ASP264J, ASP276J, ASP293J, ASP303J, ASP308J, ASP315J, ASP325J, ASP328J, ASP367J, ASP393J, ASP548I, ASP56J, ASP595I, ASP600I, ASP71J, ASP75J, CYS365J, GLN358J, GLN58J, GLN601I, GLN643I, GLN99I, GLU262J, GLU266J, GLU270J, GLU284J, GLU299J, GLU318J, GLU326J, GLU437I, GLU440I, GLU476I, GLU537I, GLU552I, GLU558I, GLU645I, GLU652I, GLU68J, GLU691I, GLU696I, GLU76J, GLY112J, GLY116J, GLY327J, GLY349J, GLY364J, GLY438I, GLY439I, GLY477I, GLY545I, GLY556I, GLY599I, GLY60J, GLY623I, GLY624I, GLY62J, GLY77J, HIS321J, HIS551I, HIS59J, HIS637I, ILE114J, ILE298J, ILE538I, ILE55J, ILE619I, ILE698I, LEU268J, LEU274J, LEU278J, LEU280J, LEU302J, LEU305J, LEU319J, LEU360J, LEU362J, LEU366J, LEU398J, LEU417I, LEU646I, LEU649I, LEU64J, LEU654I, LEU72J, LEU73J, LEU74J, LYS218J, LYS285J, LYS322J, LYS433J, LYS466J, LYS618I, LYS635I, LYS63J, LYS653I, LYS694I, LYS98I, MET197J, MET547I, MET650I, MET666I, MET693I, MET695I, PHE261J, PHE277J, PHE291J, PHE292J, PHE329J, PHE397J, PHE79J, PRO279J, PRO286J, PRO287J, PRO290J, PRO300J, PRO307J, PRO310J, PRO313J, PRO359J, PRO395J, PRO399J, PRO598I, PRO641I, PRO651I, PRO655I, PRO656I, PRO665I, PRO667I, SER220J, SER301J, SER544I, SER620I, SER78J, THR113J, THR248J, THR304J, THR312J, THR418I, THR541I, THR557I, THR597I, THR640I, THR65J, THR689I, TRP111J, TRP455J, TRP559I, TRP596I, TYR314J, TYR330J, TYR420I, TYR436I, VAL118J, VAL119J, VAL217J, VAL265J, VAL271J, VAL275J, VAL288J, VAL306J, VAL361J, VAL394J, VAL535I, VAL543I, VAL555I, VAL671I, VAL70J
• J-K: ALA516J, ALA518J, ALA520J, ARG289J, ARG350J, ARG512J, ARG514J, ARG517J, ARG523J, ARG546K, ARG554K, ASN524J, ASN550K, ASP294J, ASP296J, ASP325J, ASP548K, GLU348J, GLY349J, HIS551K, LEU347J, LEU522J, LYS513J, MET547K, PHE291J, PHE519J, PRO295J, SER521J, VAL288J, VAL515J
• J-L: ALA103L, ALA148L, ALA153L, ALA449J, ALA454J, ALA458J, ALA496J, ALA516J, ALA518J, ALA520J, ARG283L, ARG42L, ARG43L, ARG448J, ARG47L, ARG499J, ARG509J, ARG514J, ARG517J, ARG523J, ARG89L, ASN151L, ASN281L, ASN452J, ASN492J, ASN524J, ASP105L, ASP146L, ASP303J, ASP450J, ASP503J, ASP83L, GLN150L, GLN38L, GLN507J, GLN528J, GLU135L, GLU284L, GLU37L, GLU40L, GLU498J, GLU504J, GLU80L, GLU81L, GLY104L, GLY110L, GLY112L, GLY152L, GLY500J, GLY77L, HIS88L, ILE144L, ILE506J, LEU280L, LEU36L, LEU39L, LEU522J, LYS101L, LYS139L, LYS140L, LYS143L, LYS285J, LYS445J, LYS513J, LYS525J, MET147L, MET149L, MET84L, PHE451J, PHE494J, PHE501J, PHE519J, PHE79L, PHE82L, PHE85L, PRO102L, PRO425J, PRO456J, PRO493J, PRO508J, SER497J, SER510J, SER521J, SER526J, SER78L, THR113L, THR136L, THR423J, THR457J, THR87L, TRP111L, TRP455J, TYR120L, TYR453J, VAL118L, VAL119L, VAL190L, VAL495J, VAL502J, VAL505J, VAL515J, VAL527J, VAL86L
• K-L: ALA267L, ALA269L, ALA324L, ALA536K, ALA644K, ALA647K, ALA692K, ALA96K, ARG117L, ARG252L, ARG272L, ARG273L, ARG289L, ARG297L, ARG416K, ARG419K, ARG539K, ARG540K, ARG542K, ARG546K, ARG553K, ARG554K, ARG61L, ARG639K, ARG642K, ARG648K, ARG67L, ARG69L, ASN115L, ASN263L, ASN309L, ASN311L, ASN697K, ASP219L, ASP264L, ASP276L, ASP293L, ASP303L, ASP308L, ASP315L, ASP325L, ASP328L, ASP548K, ASP56L, ASP600K, ASP71L, ASP75L, GLN58L, GLN601K, GLN643K, GLN99K, GLU262L, GLU266L, GLU270L, GLU284L, GLU299L, GLU318L, GLU326L, GLU437K, GLU440K, GLU476K, GLU537K, GLU552K, GLU558K, GLU645K, GLU652K, GLU68L, GLU691K, GLU696K, GLU76L, GLY112L, GLY116L, GLY327L, GLY438K, GLY439K, GLY477K, GLY545K, GLY556K, GLY599K, GLY60L, GLY623K, GLY624K, GLY62L, GLY77L, HIS321L, HIS551K, HIS59L, HIS637K, ILE114L, ILE298L, ILE538K, ILE55L, ILE619K, ILE698K, LEU268L, LEU274L, LEU278L, LEU280L, LEU302L, LEU305L, LEU319L, LEU417K, LEU646K, LEU649K, LEU64L, LEU654K, LEU72L, LEU73L, LEU74L, LYS218L, LYS285L, LYS322L, LYS433L, LYS466L, LYS618K, LYS635K, LYS63L, LYS653K, LYS694K, LYS98K, MET197L, MET547K, MET650K, MET693K, MET695K, PHE261L, PHE277L, PHE291L, PHE292L, PHE329L, PHE79L, PRO279L, PRO286L, PRO287L, PRO290L, PRO300L, PRO307L, PRO310L, PRO313L, PRO598K, PRO641K, PRO651K, PRO655K, PRO656K, SER220L, SER301L, SER544K, SER620K, SER78L, THR113L, THR304L, THR312L, THR418K, THR541K, THR557K, THR597K, THR640K, THR65L, THR689K, TRP111L, TRP559K, TRP596K, TYR314L, TYR420K, TYR436K, VAL118L, VAL119L, VAL217L, VAL265L, VAL271L, VAL275L, VAL288L, VAL306L, VAL535K, VAL543K, VAL555K, VAL671K, VAL70L