3N56

crystal structure of human insulin-degrading enzyme (ide) in complex with human b-type natriuretic peptide (bnp)

• Total interactions analyzed: 6
• Total true interactions: 3
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 92
  • Norm. En. per Res.: -1.9854
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-17.0777	-8.7008	-156.878	-182.6565	92	8	0	7175	4	75	75
A-C	-4.1974	0.0	-29.3149	-33.5123	28	2	0	1376	0	0	0
B-D	0.0	0.0	-32.6605	-32.6605	28	2	0	1439	0	0	0

Interface residues

• A-B: ALA161B, ALA403A, ALA419A, ALA452A, ALA881B, ARG164B, ARG423A, ARG460A, ARG49A, ASN528A, ASN52A, ASP163B, ASP175B, ASP416A, ASP60A, ASP876B, ASP935B, GLN129B, GLN167B, GLN407A, GLN412A, GLN883B, GLU126B, GLU133B, GLU159B, GLU404A, GLU408A, GLU413A, GLU447A, GLU448A, GLU457A, GLU458A, GLU529A, GLU59A, GLU875B, GLU879B, GLU880B, GLU934B, GLY160B, GLY405A, GLY51A, HIS134B, HIS157B, HIS53A, ILE50A, ILE531A, ILE54A, ILE874B, ILE937B, LEU162B, LEU173B, LEU274B, LEU455A, LEU456A, LEU524A, LYS119B, LYS120B, LYS123B, LYS273B, LYS327A, LYS415A, LYS527A, LYS56A, LYS872B, LYS884B, LYS933B, LYS938B, MET877B, PHE130B, PHE411A, PHE422A, PHE459A, PHE882B, PRO122B, PRO406A, PRO445A, PRO461A, PRO58A, SER328A, SER57A, SER873B, THR118B, THR451A, THR526A, THR533A, THR55A, THR878B, THR932B, TRP409A, TYR121B, TYR326A, VAL410A
• A-C: ASN376A, GLN363A, GLU341A, GLU365A, GLY331A, GLY335A, GLY339A, GLY361A, GLY362A, HIS332A, HIS336A, HIS340A, ILE338A, ILE374A, ILE375A, LEU334A, LEU337A, LEU359A, LEU414A, LEU613A, LYS364A, PHE372A, PHE373A, PRO2C, SER1C, TYR333A, TYR609A, VAL360A
• B-D: ASN376B, GLN363B, GLU341B, GLU365B, GLY331B, GLY335B, GLY339B, GLY361B, GLY362B, HIS332B, HIS336B, HIS340B, ILE338B, ILE374B, ILE375B, LEU334B, LEU337B, LEU359B, LEU414B, LEU613B, LYS364B, PHE372B, PHE373B, PRO2D, SER1D, TYR333B, TYR609B, VAL360B