3N2N

the crystal structure of tumor endothelial marker 8 (tem8) extracellular domain

• Total interactions analyzed: 15
• Total true interactions: 12
• Strongest Interaction:
  • Chains: B-E
  • Int. Res.: 56
  • Norm. En. per Res.: -3.676
• Hub Node: F(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
F-A	0.0	50.3004	-51.0872	-0.7868	34	2	0	2115	0	28	23
F-C	-46.9891	5.9733	-153.904	-194.9197	54	7	3	5379	0	8	9
F-D	-6.1915	15.8815	-69.7443	-60.0543	50	1	0	3132	0	22	16
F-E	0.0	16.8241	-81.7146	-64.8905	49	2	0	3354	0	24	16
A-B	0.0	16.7097	-70.9217	-54.212	49	3	0	3210	0	24	17
A-C	0.0	17.7141	-88.7096	-70.9955	57	2	0	3427	0	24	17
A-D	-47.752	5.9217	-163.749	-205.5793	57	9	3	5912	0	8	9
B-C	0.0	5.6364	-77.0247	-71.3883	54	2	0	3077	1	24	15
B-D	0.0	28.4942	-63.6133	-35.1191	38	4	0	2557	2	28	23
B-E	-50.1	6.2607	-162.015	-205.8543	56	7	3	5535	0	8	9
C-E	0.0	53.7013	-45.7371	7.9642	36	3	0	2058	1	28	23
D-E	-4.7165	17.352	-72.4959	-59.8604	52	2	0	3278	0	22	15

Interface residues

• F-A: ARG136A, ARG136F, ARG163A, ARG163F, ARG167A, ARG167F, ARG169A, ARG169F, ASN135A, ASN135F, ASN166A, ASN166F, ASP156A, ASP156F, ASP170A, ASP170F, GLU125F, GLU129F, GLU155A, GLU155F, GLU162A, GLU162F, GLU164A, GLU164F, LEU171A, LEU171F, PHE159A, PHE159F, SER128A, SER128F, TYR132A, TYR132F, TYR160A, TYR160F
• F-C: ALA173C, ALA173F, ALA38C, ALA38F, ARG136C, ARG136F, ARG140C, ARG140F, ARG167C, ARG167F, ARG169C, ARG169F, ASN135C, ASN135F, ASP170C, ASP170F, CYS220C, CYS220F, CYS39C, CYS39F, GLN137C, GLN137F, GLU134C, GLU134F, GLY138C, GLY138F, GLY172C, GLY172F, GLY41C, GLY41F, GLY42C, GLY42F, ILE131C, ILE131F, LEU171C, LEU171F, LYS218F, MET37C, MET37F, SER168C, SER168F, SER219C, SER219F, SER36C, SER36F, THR141C, THR141F, TYR132C, TYR132F, TYR133F, TYR139C, TYR139F, TYR40C, TYR40F
• F-D: ALA165F, ALA189F, ALA207D, ALA38D, ARG163F, ARG190F, ASN166F, ASN184F, ASP182F, ASP196D, ASP196F, CYS220D, CYS39D, GLN187F, GLN206D, GLN209D, GLU152F, GLU155F, GLU162F, GLU164F, GLU185F, GLY210D, HIS154F, HIS197D, HIS213D, ILE191F, ILE211D, ILE212D, ILE215D, LEU153F, LEU188F, LEU208D, LEU216D, LYS195F, LYS217D, LYS218D, MET37D, PHE158F, PHE159F, PHE183F, PHE199D, SER161F, SER194F, SER214D, SER219D, SER36D, THR186F, TYR160F, TYR176D, TYR40D
• F-E: ALA142F, ALA165E, ALA189E, ALA207F, ALA38F, ARG140F, ARG163E, ARG190E, ASN166E, ASN184E, ASP196E, ASP196F, CYS220F, CYS39F, GLN187E, GLN209F, GLU152E, GLU155E, GLU162E, GLU164E, GLU185E, GLY210F, HIS154E, HIS197F, HIS213F, ILE191E, ILE211F, ILE212F, ILE215F, LEU153E, LEU188E, LEU208F, LEU216F, LYS195E, LYS217F, LYS218F, MET37F, PHE158E, PHE159E, PHE183E, PHE199F, SER161E, SER214F, SER219F, SER36F, THR186E, TYR160E, TYR176F, TYR40F
• A-B: ALA189B, ALA207A, ALA38A, ARG163B, ARG167B, ARG190B, ASN166B, ASN184B, ASP182B, ASP196A, ASP196B, CYS220A, CYS39A, GLN187B, GLN206A, GLN209A, GLU152B, GLU155B, GLU162B, GLU164B, GLU185B, GLY151B, GLY210A, HIS154B, HIS197A, HIS213A, ILE211A, ILE212A, ILE215A, LEU153B, LEU188B, LEU208A, LEU216A, LYS195B, LYS217A, LYS218A, MET37A, PHE158B, PHE159B, PHE183B, PHE199A, PHE73A, SER214A, SER219A, SER36A, THR186B, TYR160B, TYR176A, TYR40A
• A-C: ALA142C, ALA165A, ALA189A, ALA207C, ALA38C, ARG140C, ARG163A, ARG190A, ASN166A, ASN184A, ASP193C, ASP196A, ASP196C, CYS220C, CYS39C, GLN187A, GLN206C, GLN209C, GLU152A, GLU155A, GLU162A, GLU164A, GLU185A, GLY151A, GLY210C, HIS154A, HIS197C, HIS213C, ILE174C, ILE191A, ILE211C, ILE212C, ILE215C, LEU153A, LEU188A, LEU208C, LEU216C, LYS195A, LYS195C, LYS217C, LYS218C, MET37C, PHE158A, PHE159A, PHE183A, PHE199C, SER161A, SER194A, SER194C, SER214C, SER219C, SER36C, THR186A, TYR160A, TYR176C, TYR40C, VAL198C
• A-D: ALA173A, ALA173D, ALA38A, ALA38D, ARG136A, ARG136D, ARG140A, ARG140D, ARG167A, ARG167D, ARG169A, ARG169D, ASN135A, ASN135D, ASN166D, ASP170A, ASP170D, CYS220A, CYS220D, CYS39A, CYS39D, GLN137A, GLN137D, GLU134A, GLU134D, GLY138A, GLY138D, GLY172A, GLY172D, GLY41A, GLY41D, GLY42A, GLY42D, ILE131A, ILE131D, LEU171A, LEU171D, LYS218A, LYS218D, MET37A, MET37D, SER143D, SER168A, SER168D, SER219A, SER219D, SER36A, SER36D, THR141A, THR141D, TYR132A, TYR132D, TYR133D, TYR139A, TYR139D, TYR40A, TYR40D
• B-C: ALA165C, ALA189C, ALA207B, ALA38B, ARG163C, ARG190C, ASN166C, ASN184C, ASP182C, ASP196B, ASP196C, CYS220B, CYS39B, GLN187C, GLN206B, GLN209B, GLU152C, GLU155C, GLU162C, GLU164C, GLU185C, GLY151C, GLY210B, HIS154C, HIS197B, HIS213B, ILE191C, ILE211B, ILE212B, ILE215B, LEU153C, LEU188C, LEU208B, LEU216B, LYS195B, LYS195C, LYS217B, LYS218B, MET37B, PHE158C, PHE159C, PHE183C, PHE199B, SER161C, SER194B, SER194C, SER214B, SER219B, SER36B, THR186C, TYR160C, TYR176B, TYR40B, VAL198B
• B-D: ALA165B, ARG136B, ARG136D, ARG163B, ARG163D, ARG167B, ARG167D, ARG169B, ARG169D, ASN135B, ASN135D, ASN166B, ASN166D, ASP156B, ASP156D, ASP170B, ASP170D, GLU125B, GLU125D, GLU129B, GLU155B, GLU155D, GLU162B, GLU162D, GLU164B, GLU164D, LEU171B, LEU171D, PHE159B, PHE159D, SER128B, SER128D, SER168B, SER168D, TYR132B, TYR132D, TYR160B, TYR160D
• B-E: ALA173B, ALA173E, ALA38B, ALA38E, ARG136B, ARG136E, ARG140B, ARG140E, ARG167B, ARG167E, ARG169B, ARG169E, ASN135B, ASN135E, ASP170B, ASP170E, CYS220B, CYS220E, CYS39B, CYS39E, GLN137B, GLN137E, GLU134B, GLU134E, GLY138B, GLY138E, GLY172B, GLY172E, GLY41B, GLY41E, GLY42B, GLY42E, ILE131B, ILE131E, LEU171B, LEU171E, LYS218B, LYS218E, MET37B, MET37E, SER143E, SER168B, SER168E, SER219B, SER219E, SER36B, SER36E, THR141B, THR141E, TYR132B, TYR132E, TYR133E, TYR139B, TYR139E, TYR40B, TYR40E
• C-E: ARG136C, ARG136E, ARG163C, ARG163E, ARG167C, ARG167E, ARG169C, ARG169E, ASN135C, ASN135E, ASN166C, ASN166E, ASP156C, ASP156E, ASP170C, ASP170E, GLU125C, GLU155C, GLU155E, GLU162C, GLU162E, GLU164C, GLU164E, HIS121C, ILE131C, ILE131E, LEU171C, LEU171E, PHE159C, PHE159E, SER128C, SER128E, TYR132C, TYR132E, TYR160C, TYR160E
• D-E: ALA165D, ALA189D, ALA207E, ALA38E, ARG163D, ARG167D, ARG190D, ASN166D, ASN184D, ASP182D, ASP196D, ASP196E, CYS220E, CYS39E, GLN187D, GLN206E, GLN209E, GLU152D, GLU155D, GLU162D, GLU164D, GLU185D, GLY210E, HIS154D, HIS197E, HIS213E, ILE191D, ILE211E, ILE212E, ILE215E, LEU153D, LEU188D, LEU208E, LEU216E, LYS195D, LYS217E, LYS218E, MET37E, PHE158D, PHE159D, PHE183D, PHE199E, PHE73E, SER161D, SER194D, SER214E, SER219E, SER36E, THR186D, TYR160D, TYR176E, TYR40E