3MYR

crystal structure of [nife] hydrogenase from allochromatium vinosum in its ni-a state

• Total interactions analyzed: 28
• Total true interactions: 17
• Strongest Interaction:
  • Chains: G-H
  • Int. Res.: 330
  • Norm. En. per Res.: -4.5225
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-250.7411	-20.6315	-1170.23	-1441.6026	331	47	19	45118	12	93	87
A-C	-29.7838	7.9591	-174.885	-196.7097	81	10	3	6791	4	28	33
A-D	-20.5488	-21.5232	-193.829	-235.901	83	6	8	8000	3	27	24
A-G	-39.9684	27.8678	-164.391	-176.4916	103	11	0	6678	0	21	30
A-H	0.0	0.0	-8.983	-8.983	18	0	0	560	0	4	2
B-C	-20.5903	-9.801	-175.352	-205.7433	83	2	8	7499	2	27	24
B-D	-33.9209	0.961	-150.58	-183.5399	60	6	3	5468	4	14	8
B-E	0.0	-0.9692	-0.1984	-1.1676	5	0	0	52	0	4	5
B-G	0.0	0.0	-8.7828	-8.7828	15	0	0	443	0	4	3
C-D	-244.1755	-10.1225	-1173.16	-1427.458	333	44	17	45081	10	98	85
C-H	0.0	0.0	-0.0247	-0.0247	2	0	0	16	0	4	1
E-F	-270.7281	-55.0094	-1162.36	-1488.0975	336	48	20	44881	10	95	87
E-G	-33.8442	9.4696	-172.283	-196.6576	80	9	3	6687	3	28	33
E-H	-14.4573	-10.3473	-176.953	-201.7576	84	3	8	7537	2	27	24
F-G	-19.6884	-14.3337	-183.942	-217.9641	83	5	8	7887	3	27	24
F-H	-31.7397	1.0021	-154.732	-185.4696	58	3	4	5546	4	12	8
G-H	-246.1468	-66.2273	-1180.04	-1492.4141	330	46	19	44975	11	95	85

Interface residues

• A-B: ALA1053B, ALA1055B, ALA1088B, ALA1168B, ALA1194B, ALA1196B, ALA1202B, ALA1206B, ALA1233B, ALA124A, ALA131A, ALA1361B, ALA1557B, ALA202A, ALA210A, ALA245A, ALA260A, ALA26A, ALA28A, ALA3A, ALA49A, ALA50A, ALA54A, ALA55A, ALA57A, ALA58A, ALA62A, ALA91A, ARG1012B, ARG1018B, ARG1039B, ARG1048B, ARG1051B, ARG1059B, ARG1154B, ARG1199B, ARG1238B, ARG125A, ARG1356B, ARG1487B, ARG1500B, ARG192A, ARG218A, ARG25A, ARG4A, ARG59A, ARG5A, ASN1087B, ASN1169B, ASN1212B, ASN1216B, ASN127A, ASN1351B, ASN1464B, ASN228A, ASN236A, ASN66A, ASN84A, ASN95A, ASP1008B, ASP1049B, ASP1052B, ASP1103B, ASP1115B, ASP1200B, ASP1227B, ASP1229B, ASP1231B, ASP1355B, ASP1459B, ASP206A, ASP207A, ASP237A, ASP259A, ASP33A, ASP37A, ASP42A, ASP75A, CYS1061B, CYS1064B, CYS115A, CYS149A, CYS1555B, CYS1558B, CYS16A, CYS19A, CYS230A, CYS249A, CYS252A, GLN1058B, GLN1099B, GLN1163B, GLN1198B, GLN123A, GLN1366B, GLN14A, GLN1541B, GLN212A, GLN256A, GLN48A, GLN61A, GLU1014B, GLU1042B, GLU1160B, GLU1193B, GLU1241B, GLU1353B, GLU1465B, GLU1469B, GLU15A, GLU203A, GLU208A, GLU21A, GLU244A, GLU265A, GLU32A, GLU53A, GLU56A, GLU65A, GLY1015B, GLY1035B, GLY1040B, GLY1047B, GLY1062B, GLY1162B, GLY1165B, GLY1170B, GLY1209B, GLY120A, GLY1210B, GLY1220B, GLY1221B, GLY130A, GLY1359B, GLY148A, GLY18A, GLY209A, GLY213A, GLY220A, GLY238A, GLY246A, GLY261A, GLY262A, GLY52A, GLY76A, GLY86A, GLY92A, HIS1016B, HIS1068B, HIS1102B, HIS1110B, HIS1205B, HIS1214B, HIS1550B, HIS1561B, HIS247A, HIS27A, HIS44A, HIS45A, HIS93A, ILE1005B, ILE1010B, ILE1013B, ILE1019B, ILE1041B, ILE1044B, ILE1060B, ILE1155B, ILE1166B, ILE1207B, ILE1226B, ILE152A, ILE1543B, ILE1545B, ILE1549B, ILE1556B, ILE156A, ILE35A, ILE39A, ILE78A, ILE98A, LEU1017B, LEU1045B, LEU1111B, LEU1114B, LEU1164B, LEU1192B, LEU1195B, LEU11A, LEU121A, LEU1228B, LEU1234B, LEU1245B, LEU1352B, LEU1367B, LEU1546B, LEU216A, LEU219A, LEU23A, LEU250A, LEU31A, LEU34A, LEU36A, LEU41A, LEU47A, LYS1046B, LYS1153B, LYS1156B, LYS1203B, LYS1211B, LYS1237B, LYS1365B, LYS1461B, LYS1540B, LYS211A, LYS222A, LYS234A, MET1037B, MET1106B, MET154A, PHE1056B, PHE1158B, PHE1167B, PHE1204B, PHE1208B, PHE1217B, PHE13A, PHE1463B, PHE195A, PHE205A, PHE257A, PHE263A, PHE38A, PHE87A, PRO1009B, PRO1050B, PRO1085B, PRO1213B, PRO1215B, PRO1223B, PRO1225B, PRO122A, PRO126A, PRO128A, PRO1362B, PRO1363B, PRO1470B, PRO150A, PRO151A, PRO153A, PRO1542B, PRO242A, PRO248A, PRO29A, PRO6A, PRO79A, PRO85A, SER1161B, SER1224B, SER1230B, SER1232B, SER12A, SER204A, SER22A, SER240A, SER40A, SER51A, SER77A, SER7A, SER88A, SER94A, SER97A, THR1011B, THR1036B, THR1043B, THR1065B, THR114A, THR1151B, THR1157B, THR1201B, THR129A, THR1350B, THR1460B, THR1462B, THR157A, THR17A, THR20A, THR239A, THR24A, THR30A, THR46A, THR89A, TRP1054B, TRP10A, TRP1172B, TRP1197B, TRP1332B, TRP1375B, TRP1468B, TRP214A, TRP235A, TRP241A, TRP258A, TYR1109B, TYR1171B, TYR1177B, TYR1191B, TYR1354B, TYR1364B, TYR191A, TYR264A, TYR43A, VAL1006B, VAL1007B, VAL1038B, VAL1057B, VAL1063B, VAL1073B, VAL1117B, VAL1119B, VAL1159B, VAL1188B, VAL1218B, VAL1219B, VAL1222B, VAL1360B, VAL1539B, VAL1560B, VAL243A, VAL8A, VAL90A
• A-C: ALA180C, ALA210A, ALA210C, ALA229A, ALA229C, ALA231A, ALA231C, ARG189A, ARG189C, ARG192A, ARG192C, ARG193A, ARG193C, ASP188A, ASP188C, ASP197A, ASP197C, ASP237A, ASP237C, CYS190A, CYS190C, CYS215A, CYS215C, CYS230A, CYS230C, GLN184A, GLN184C, GLN212A, GLN212C, GLU171C, GLU244A, GLU244C, GLY183A, GLY183C, GLY209A, GLY209C, GLY213A, GLY213C, GLY238A, GLY238C, HIS187A, HIS187C, ILE186A, ILE186C, LEU179A, LEU179C, LEU200A, LEU200C, LYS198A, LYS198C, LYS211A, LYS211C, LYS234A, LYS234C, MET154A, MET154C, MET233A, MET233C, PHE195A, PHE195C, PRO194A, PRO194C, SER185A, SER185C, SER240A, SER240C, THR232A, THR232C, THR239A, THR239C, TRP214A, TRP214C, TRP241A, TRP241C, TYR191A, TYR191C, TYR196A, TYR196C, TYR227C, VAL243A, VAL243C
• A-D: ALA1233D, ALA1236D, ALA1240D, ALA1453D, ALA161A, ALA180A, ALA229A, ALA231A, ALA26A, ALA28A, ARG1238D, ARG1243D, ARG168A, ARG189A, ASN1235D, ASN1244D, ASN1454D, ASN228A, ASP1200D, ASP1227D, ASP1229D, ASP1231D, ASP1459D, ASP188A, ASP237A, ASP33A, ASP37A, GLN1247D, GLN184A, GLU1241D, GLU171A, GLY1458D, GLY158A, GLY167A, GLY183A, GLY238A, HIS162A, HIS27A, ILE1207D, ILE1226D, ILE1452D, ILE152A, ILE156A, ILE160A, LEU1228D, LEU1239D, LEU1245D, LEU1451D, LEU164A, LEU169A, LEU172A, LEU179A, LEU34A, LYS1203D, LYS1237D, LYS1456D, LYS234A, MET154A, MET233A, PHE166A, PHE181A, PHE38A, PRO153A, PRO170A, PRO178A, PRO29A, SER1230D, SER1232D, SER1248D, SER1457D, SER185A, THR1460D, THR157A, THR232A, THR30A, TYR1448D, TYR163A, TYR182A, VAL1242D, VAL1455D, VAL155A, VAL159A, VAL165A
• A-G: ALA131A, ALA131G, ALA260A, ALA260G, ALA83A, ALA83G, ARG125A, ARG125G, ARG139A, ARG139G, ARG177A, ARG177G, ASN127A, ASN127G, ASN145A, ASN145G, ASP136A, ASP136G, ASP140A, ASP140G, ASP173A, ASP173G, ASP259A, ASP259G, ASP82A, ASP82G, GLN123A, GLN123G, GLN256A, GLN256G, GLU254A, GLU265G, GLY130A, GLY130G, GLY174A, GLY174G, GLY176A, GLY176G, GLY183A, GLY183G, GLY261A, GLY261G, GLY262G, GLY80A, GLY80G, ILE144A, ILE144G, LEU137A, LEU137G, LEU172A, LEU172G, LEU179A, LEU179G, LYS141A, LYS141G, LYS222A, LYS222G, MET132A, MET132G, MET135A, MET135G, PHE118A, PHE118G, PHE257A, PHE257G, PRO126A, PRO126G, PRO128A, PRO128G, PRO142A, PRO142G, PRO255A, PRO255G, PRO270A, PRO270G, PRO81A, PRO81G, SER133A, SER133G, SER268A, SER268G, THR225A, THR225G, TRP258A, TRP258G, TYR175A, TYR175G, TYR227A, TYR227G, TYR96A, TYR96G, VAL109A, VAL109G, VAL134A, VAL134G, VAL138A, VAL138G, VAL143A, VAL143G, VAL267A, VAL267G, VAL269A, VAL269G
• A-H: ALA1502H, ARG1048H, ARG125A, ARG1500H, ASN1351H, GLN1349H, GLY1047H, ILE1044H, ILE1501H, LEU1045H, LEU1352H, LYS1046H, PRO270A, SER268A, THR1043H, THR1350H, VAL267A, VAL269A
• B-C: ALA1233B, ALA1236B, ALA1240B, ALA1453B, ALA161C, ALA180C, ALA229C, ALA231C, ALA26C, ALA28C, ARG1238B, ARG1243B, ARG168C, ARG189C, ASN1235B, ASN1244B, ASN1454B, ASN228C, ASP1200B, ASP1227B, ASP1229B, ASP1231B, ASP1459B, ASP188C, ASP237C, ASP33C, ASP37C, GLN1247B, GLN184C, GLU1241B, GLU171C, GLY1458B, GLY158C, GLY167C, GLY183C, GLY238C, HIS162C, HIS27C, ILE1207B, ILE1226B, ILE1452B, ILE152C, ILE156C, ILE160C, LEU1228B, LEU1234B, LEU1239B, LEU1245B, LEU1451B, LEU164C, LEU169C, LEU172C, LEU179C, LEU34C, LYS1203B, LYS1237B, LYS1456B, LYS234C, MET154C, MET233C, PHE166C, PHE181C, PHE38C, PRO153C, PRO170C, PRO178C, PRO29C, SER1230B, SER1232B, SER1457B, SER185C, THR1460B, THR157C, THR232C, THR30C, TYR1448B, TYR163C, TYR182C, VAL1242B, VAL1455B, VAL155C, VAL159C, VAL165C
• B-D: ALA1134B, ALA1134D, ALA1139B, ALA1139D, ALA1149B, ALA1149D, ALA1189B, ALA1189D, ARG1128B, ARG1128D, ARG1154B, ARG1154D, ARG1199B, ARG1199D, ARG1243D, ASN1244B, ASN1244D, ASP1150B, ASP1150D, GLN1135B, GLN1135D, GLN1247B, GLN1247D, GLN1255B, GLN1255D, GLU1132B, GLU1132D, GLU1193B, GLU1193D, GLY1146B, GLY1146D, LEU1133B, LYS1142B, LYS1142D, LYS1203B, LYS1203D, PHE1148B, PHE1148D, PRO1127D, PRO1141B, PRO1141D, PRO1145B, PRO1145D, SER1131B, SER1131D, SER1136B, SER1136D, SER1138B, SER1138D, SER1143B, SER1143D, SER1144B, SER1144D, THR1151B, THR1151D, THR1251D, TRP1140B, TRP1140D, TYR1147B, TYR1147D
• B-E: ARG1356B, ASP1355B, ASP197E, LEU200E, LYS198E
• B-G: ALA1502B, ARG1048B, ARG125G, ARG1500B, ASN1351B, GLY1047B, ILE1044B, ILE1501B, LEU1045B, LYS1046B, PRO270G, SER268G, THR1043B, VAL267G, VAL269G
• C-D: ALA1053D, ALA1055D, ALA1168D, ALA1194D, ALA1196D, ALA1202D, ALA1206D, ALA1233D, ALA124C, ALA131C, ALA1361D, ALA1557D, ALA202C, ALA210C, ALA245C, ALA260C, ALA26C, ALA28C, ALA3C, ALA49C, ALA50C, ALA54C, ALA55C, ALA57C, ALA58C, ALA62C, ALA91C, ARG1012D, ARG1018D, ARG1039D, ARG1048D, ARG1051D, ARG1059D, ARG1154D, ARG1199D, ARG1238D, ARG125C, ARG1356D, ARG1487D, ARG1500D, ARG192C, ARG218C, ARG25C, ARG4C, ARG59C, ARG5C, ASN1087D, ASN1169D, ASN1212D, ASN1216D, ASN127C, ASN1351D, ASN1464D, ASN228C, ASN236C, ASN66C, ASN84C, ASN95C, ASP1008D, ASP1049D, ASP1052D, ASP1103D, ASP1115D, ASP1118D, ASP1200D, ASP1227D, ASP1229D, ASP1231D, ASP1355D, ASP1459D, ASP206C, ASP207C, ASP237C, ASP259C, ASP33C, ASP37C, ASP42C, ASP75C, CYS1061D, CYS1064D, CYS115C, CYS149C, CYS1555D, CYS1558D, CYS16C, CYS19C, CYS230C, CYS249C, CYS252C, GLN1058D, GLN1099D, GLN1163D, GLN1198D, GLN123C, GLN1366D, GLN14C, GLN1541D, GLN212C, GLN256C, GLN48C, GLN61C, GLU1014D, GLU1042D, GLU1160D, GLU1193D, GLU1241D, GLU1353D, GLU1465D, GLU1469D, GLU15C, GLU203C, GLU208C, GLU21C, GLU244C, GLU265C, GLU32C, GLU53C, GLU56C, GLU65C, GLY1015D, GLY1035D, GLY1040D, GLY1047D, GLY1062D, GLY1162D, GLY1165D, GLY1170D, GLY1209D, GLY120C, GLY1210D, GLY1220D, GLY1221D, GLY130C, GLY1359D, GLY148C, GLY18C, GLY209C, GLY213C, GLY220C, GLY238C, GLY246C, GLY261C, GLY262C, GLY52C, GLY76C, GLY86C, GLY92C, HIS1016D, HIS1068D, HIS1102D, HIS1110D, HIS1205D, HIS1214D, HIS1550D, HIS1561D, HIS247C, HIS27C, HIS44C, HIS45C, HIS93C, ILE1010D, ILE1013D, ILE1019D, ILE1041D, ILE1044D, ILE1060D, ILE1155D, ILE1166D, ILE1207D, ILE1226D, ILE152C, ILE1543D, ILE1545D, ILE1556D, ILE156C, ILE35C, ILE39C, ILE78C, ILE98C, LEU1017D, LEU1045D, LEU1111D, LEU1114D, LEU1164D, LEU1192D, LEU1195D, LEU11C, LEU121C, LEU1228D, LEU1234D, LEU1245D, LEU1352D, LEU1367D, LEU1546D, LEU216C, LEU219C, LEU23C, LEU250C, LEU31C, LEU34C, LEU36C, LEU41C, LEU47C, LYS1046D, LYS1153D, LYS1156D, LYS1203D, LYS1211D, LYS1237D, LYS1365D, LYS1461D, LYS1540D, LYS211C, LYS222C, LYS234C, MET1037D, MET1095D, MET1106D, MET154C, PHE1056D, PHE1158D, PHE1167D, PHE1204D, PHE1208D, PHE1217D, PHE13C, PHE1463D, PHE195C, PHE205C, PHE257C, PHE263C, PHE38C, PHE87C, PRO1009D, PRO1050D, PRO1085D, PRO1213D, PRO1215D, PRO1223D, PRO1225D, PRO122C, PRO126C, PRO128C, PRO1362D, PRO1363D, PRO1470D, PRO150C, PRO151C, PRO153C, PRO1542D, PRO242C, PRO248C, PRO266C, PRO29C, PRO6C, PRO79C, PRO85C, SER1034D, SER1161D, SER1224D, SER1230D, SER1232D, SER12C, SER204C, SER22C, SER240C, SER253C, SER40C, SER51C, SER77C, SER7C, SER88C, SER94C, SER97C, THR1011D, THR1036D, THR1043D, THR1065D, THR114C, THR1151D, THR1157D, THR1201D, THR129C, THR1350D, THR1460D, THR1462D, THR157C, THR17C, THR20C, THR239C, THR24C, THR30C, THR46C, THR89C, TRP1054D, TRP10C, TRP1172D, TRP1197D, TRP1332D, TRP1375D, TRP1468D, TRP214C, TRP235C, TRP241C, TRP258C, TYR1109D, TYR1171D, TYR1177D, TYR1191D, TYR1354D, TYR1364D, TYR191C, TYR264C, TYR43C, VAL1006D, VAL1007D, VAL1038D, VAL1057D, VAL1063D, VAL1073D, VAL1117D, VAL1119D, VAL1159D, VAL1188D, VAL1218D, VAL1219D, VAL1222D, VAL1360D, VAL1539D, VAL1560D, VAL243C, VAL8C, VAL90C
• C-H: ARG1356H, LYS198C
• E-F: ALA1053F, ALA1055F, ALA1168F, ALA1194F, ALA1196F, ALA1202F, ALA1206F, ALA1233F, ALA124E, ALA131E, ALA1361F, ALA1557F, ALA202E, ALA210E, ALA245E, ALA260E, ALA26E, ALA28E, ALA3E, ALA49E, ALA50E, ALA54E, ALA55E, ALA57E, ALA58E, ALA62E, ALA91E, ARG1012F, ARG1018F, ARG1039F, ARG1048F, ARG1051F, ARG1059F, ARG1154F, ARG1199F, ARG1238F, ARG125E, ARG1356F, ARG1487F, ARG1500F, ARG192E, ARG218E, ARG25E, ARG4E, ARG59E, ARG5E, ASN1087F, ASN1169F, ASN1212F, ASN1216F, ASN127E, ASN1351F, ASN1464F, ASN228E, ASN236E, ASN66E, ASN84E, ASN95E, ASP1008F, ASP1049F, ASP1052F, ASP1103F, ASP1115F, ASP1118F, ASP1200F, ASP1227F, ASP1229F, ASP1231F, ASP1355F, ASP1459F, ASP206E, ASP207E, ASP237E, ASP259E, ASP33E, ASP37E, ASP42E, ASP75E, CYS1061F, CYS1064F, CYS115E, CYS149E, CYS1555F, CYS1558F, CYS16E, CYS19E, CYS230E, CYS249E, CYS252E, GLN1058F, GLN1099F, GLN1163F, GLN1198F, GLN123E, GLN1366F, GLN14E, GLN1541F, GLN212E, GLN256E, GLN48E, GLN61E, GLU1014F, GLU1042F, GLU1160F, GLU1193F, GLU1241F, GLU1353F, GLU1465F, GLU1469F, GLU15E, GLU203E, GLU208E, GLU21E, GLU244E, GLU265E, GLU32E, GLU53E, GLU56E, GLU65E, GLY1015F, GLY1035F, GLY1040F, GLY1047F, GLY1062F, GLY1162F, GLY1165F, GLY1170F, GLY1209F, GLY120E, GLY1210F, GLY1220F, GLY1221F, GLY130E, GLY1359F, GLY148E, GLY18E, GLY209E, GLY213E, GLY220E, GLY238E, GLY246E, GLY261E, GLY262E, GLY52E, GLY76E, GLY86E, GLY92E, HIS1016F, HIS1068F, HIS1102F, HIS1110F, HIS1205F, HIS1214F, HIS1550F, HIS1561F, HIS247E, HIS27E, HIS44E, HIS45E, HIS93E, ILE1005F, ILE1010F, ILE1013F, ILE1019F, ILE1041F, ILE1044F, ILE1060F, ILE1155F, ILE1166F, ILE1207F, ILE1226F, ILE152E, ILE1543F, ILE1545F, ILE1549F, ILE1556F, ILE156E, ILE35E, ILE39E, ILE78E, ILE98E, LEU1017F, LEU1045F, LEU1111F, LEU1114F, LEU1164F, LEU1192F, LEU1195F, LEU11E, LEU121E, LEU1228F, LEU1234F, LEU1245F, LEU1352F, LEU1367F, LEU1546F, LEU216E, LEU219E, LEU23E, LEU250E, LEU31E, LEU34E, LEU36E, LEU41E, LEU47E, LYS1046F, LYS1153F, LYS1156F, LYS1203F, LYS1211F, LYS1237F, LYS1365F, LYS1461F, LYS1540F, LYS211E, LYS222E, LYS234E, MET1037F, MET1106F, MET154E, PHE1056F, PHE1158F, PHE1167F, PHE1204F, PHE1208F, PHE1217F, PHE13E, PHE1463F, PHE195E, PHE205E, PHE257E, PHE263E, PHE38E, PHE87E, PRO1009F, PRO1050F, PRO1085F, PRO1213F, PRO1215F, PRO1223F, PRO1225F, PRO122E, PRO126E, PRO128E, PRO1362F, PRO1363F, PRO1470F, PRO150E, PRO151E, PRO153E, PRO1542F, PRO242E, PRO248E, PRO266E, PRO29E, PRO6E, PRO79E, PRO85E, SER1034F, SER1161F, SER1224F, SER1230F, SER1232F, SER12E, SER204E, SER22E, SER240E, SER253E, SER40E, SER51E, SER77E, SER7E, SER88E, SER94E, SER97E, THR1011F, THR1036F, THR1043F, THR1065F, THR114E, THR1151F, THR1157F, THR1201F, THR129E, THR1350F, THR1460F, THR1462F, THR157E, THR17E, THR20E, THR239E, THR24E, THR30E, THR46E, THR89E, TRP1054F, TRP10E, TRP1172F, TRP1197F, TRP1332F, TRP1375F, TRP1468F, TRP1473F, TRP214E, TRP235E, TRP241E, TRP258E, TYR1109F, TYR1171F, TYR1177F, TYR1191F, TYR1354F, TYR1364F, TYR191E, TYR264E, TYR43E, VAL1006F, VAL1007F, VAL1038F, VAL1057F, VAL1063F, VAL1073F, VAL1117F, VAL1119F, VAL1159F, VAL1188F, VAL1218F, VAL1219F, VAL1222F, VAL1242F, VAL1360F, VAL1539F, VAL1560F, VAL243E, VAL8E, VAL90E
• E-G: ALA180E, ALA180G, ALA210E, ALA210G, ALA229E, ALA229G, ALA231E, ALA231G, ARG189E, ARG189G, ARG192E, ARG192G, ARG193E, ARG193G, ASP188E, ASP188G, ASP197E, ASP197G, ASP237E, ASP237G, CYS190E, CYS190G, CYS215E, CYS215G, CYS230E, CYS230G, GLN184E, GLN184G, GLN212E, GLN212G, GLU171E, GLU244E, GLU244G, GLY183E, GLY183G, GLY209E, GLY213E, GLY213G, GLY238E, GLY238G, HIS187E, HIS187G, ILE186E, ILE186G, LEU179E, LEU179G, LEU200E, LEU200G, LYS198E, LYS198G, LYS211E, LYS211G, LYS234E, LYS234G, MET154G, MET233E, MET233G, PHE195E, PHE195G, PRO194E, PRO194G, SER185E, SER185G, SER240E, SER240G, THR232E, THR232G, THR239E, THR239G, TRP214E, TRP214G, TRP241E, TRP241G, TYR191E, TYR191G, TYR196E, TYR196G, TYR227G, VAL243E, VAL243G
• E-H: ALA1233H, ALA1236H, ALA1240H, ALA1453H, ALA161E, ALA180E, ALA229E, ALA231E, ALA26E, ALA28E, ARG1238H, ARG1243H, ARG168E, ARG189E, ASN1235H, ASN1244H, ASN1454H, ASN228E, ASP1200H, ASP1227H, ASP1229H, ASP1231H, ASP1459H, ASP188E, ASP237E, ASP33E, ASP37E, GLN1247H, GLN184E, GLU1241H, GLU171E, GLY1458H, GLY158E, GLY167E, GLY183E, GLY238E, HIS162E, HIS27E, ILE1207H, ILE1226H, ILE1452H, ILE152E, ILE156E, ILE160E, LEU1228H, LEU1234H, LEU1239H, LEU1245H, LEU1451H, LEU164E, LEU169E, LEU172E, LEU179E, LEU34E, LYS1203H, LYS1237H, LYS1456H, LYS234E, MET154E, MET233E, PHE166E, PHE181E, PHE38E, PRO153E, PRO170E, PRO178E, PRO29E, SER1230H, SER1232H, SER1248H, SER1457H, SER185E, THR1460H, THR157E, THR232E, THR30E, TYR1448H, TYR163E, TYR182E, VAL1242H, VAL1455H, VAL155E, VAL159E, VAL165E
• F-G: ALA1233F, ALA1236F, ALA1240F, ALA1453F, ALA161G, ALA180G, ALA229G, ALA231G, ALA26G, ALA28G, ARG1238F, ARG1243F, ARG168G, ARG189G, ASN1235F, ASN1244F, ASN1454F, ASN228G, ASP1200F, ASP1227F, ASP1229F, ASP1231F, ASP1459F, ASP188G, ASP237G, ASP33G, ASP37G, GLN1247F, GLN1445F, GLN184G, GLU1241F, GLU171G, GLY1458F, GLY158G, GLY167G, GLY183G, GLY238G, HIS162G, HIS27G, ILE1226F, ILE1452F, ILE152G, ILE156G, ILE160G, LEU1228F, LEU1234F, LEU1239F, LEU1245F, LEU1451F, LEU164G, LEU169G, LEU172G, LEU179G, LEU34G, LYS1203F, LYS1237F, LYS1456F, LYS234G, MET154G, MET233G, PHE166G, PHE181G, PHE38G, PRO153G, PRO170G, PRO178G, PRO29G, SER1230F, SER1232F, SER1457F, SER185G, THR1460F, THR157G, THR232G, THR30G, TYR1448F, TYR163G, TYR182G, VAL1242F, VAL1455F, VAL155G, VAL159G, VAL165G
• F-H: ALA1134F, ALA1134H, ALA1139F, ALA1139H, ALA1149F, ALA1149H, ALA1189F, ARG1128F, ARG1128H, ARG1154F, ARG1154H, ARG1199F, ARG1199H, ASN1244F, ASN1244H, ASP1150F, ASP1150H, GLN1135F, GLN1135H, GLN1247F, GLN1247H, GLN1255F, GLN1255H, GLU1132F, GLU1132H, GLU1193F, GLU1193H, GLY1146F, GLY1146H, LEU1133F, LYS1142F, LYS1142H, LYS1203F, LYS1203H, PHE1148F, PHE1148H, PRO1141F, PRO1141H, PRO1145F, PRO1145H, SER1131F, SER1131H, SER1136F, SER1136H, SER1138F, SER1138H, SER1143F, SER1143H, SER1144F, SER1144H, THR1151F, THR1151H, THR1251F, THR1251H, TRP1140F, TRP1140H, TYR1147F, TYR1147H
• G-H: ALA1053H, ALA1055H, ALA1168H, ALA1196H, ALA1202H, ALA1206H, ALA1233H, ALA124G, ALA131G, ALA1361H, ALA1557H, ALA202G, ALA210G, ALA245G, ALA260G, ALA26G, ALA28G, ALA3G, ALA49G, ALA50G, ALA54G, ALA55G, ALA57G, ALA58G, ALA62G, ALA91G, ARG1012H, ARG1018H, ARG1039H, ARG1048H, ARG1051H, ARG1059H, ARG1154H, ARG1199H, ARG1238H, ARG125G, ARG1356H, ARG1487H, ARG1500H, ARG192G, ARG218G, ARG25G, ARG4G, ARG59G, ARG5G, ASN1087H, ASN1169H, ASN1212H, ASN1216H, ASN127G, ASN1351H, ASN1464H, ASN228G, ASN236G, ASN66G, ASN84G, ASN95G, ASP1008H, ASP1049H, ASP1052H, ASP1103H, ASP1115H, ASP1118H, ASP1200H, ASP1227H, ASP1229H, ASP1231H, ASP1355H, ASP1459H, ASP206G, ASP207G, ASP237G, ASP259G, ASP33G, ASP37G, ASP42G, ASP75G, CYS1061H, CYS1064H, CYS115G, CYS149G, CYS1555H, CYS1558H, CYS16G, CYS19G, CYS230G, CYS249G, CYS252G, GLN1058H, GLN1099H, GLN1163H, GLN1198H, GLN123G, GLN1366H, GLN14G, GLN1541H, GLN212G, GLN256G, GLN48G, GLN61G, GLU1014H, GLU1042H, GLU1160H, GLU1193H, GLU1241H, GLU1353H, GLU1465H, GLU1469H, GLU15G, GLU203G, GLU208G, GLU21G, GLU244G, GLU265G, GLU32G, GLU53G, GLU56G, GLU65G, GLY1015H, GLY1035H, GLY1040H, GLY1062H, GLY1162H, GLY1165H, GLY1170H, GLY1209H, GLY120G, GLY1210H, GLY1220H, GLY1221H, GLY130G, GLY1359H, GLY148G, GLY18G, GLY209G, GLY213G, GLY220G, GLY238G, GLY246G, GLY261G, GLY262G, GLY52G, GLY76G, GLY86G, GLY92G, HIS1016H, HIS1068H, HIS1102H, HIS1110H, HIS1205H, HIS1214H, HIS1550H, HIS1561H, HIS247G, HIS27G, HIS44G, HIS45G, HIS93G, ILE1005H, ILE1010H, ILE1013H, ILE1019H, ILE1041H, ILE1044H, ILE1060H, ILE1155H, ILE1166H, ILE1207H, ILE1226H, ILE152G, ILE1543H, ILE1545H, ILE1556H, ILE156G, ILE35G, ILE39G, ILE78G, ILE98G, LEU1017H, LEU1045H, LEU1111H, LEU1114H, LEU1164H, LEU1192H, LEU1195H, LEU11G, LEU121G, LEU1228H, LEU1234H, LEU1245H, LEU1352H, LEU1367H, LEU1546H, LEU216G, LEU219G, LEU23G, LEU250G, LEU31G, LEU34G, LEU36G, LEU41G, LEU47G, LYS1046H, LYS1153H, LYS1156H, LYS1203H, LYS1211H, LYS1237H, LYS1365H, LYS1461H, LYS1540H, LYS211G, LYS222G, LYS234G, MET1037H, MET1095H, MET1106H, MET154G, PHE1056H, PHE1158H, PHE1167H, PHE1204H, PHE1208H, PHE1217H, PHE13G, PHE1463H, PHE195G, PHE205G, PHE257G, PHE263G, PHE38G, PHE87G, PRO1009H, PRO1050H, PRO1085H, PRO1213H, PRO1215H, PRO1223H, PRO1225H, PRO122G, PRO126G, PRO128G, PRO1362H, PRO1363H, PRO1470H, PRO150G, PRO151G, PRO153G, PRO1542H, PRO242G, PRO248G, PRO29G, PRO6G, PRO79G, PRO85G, SER1034H, SER1161H, SER1224H, SER1230H, SER1232H, SER12G, SER204G, SER22G, SER240G, SER40G, SER51G, SER77G, SER7G, SER88G, SER94G, SER97G, THR1011H, THR1036H, THR1043H, THR1065H, THR114G, THR1151H, THR1157H, THR1201H, THR129G, THR1350H, THR1460H, THR1462H, THR157G, THR17G, THR20G, THR239G, THR24G, THR30G, THR46G, THR89G, TRP1054H, TRP10G, TRP1172H, TRP1197H, TRP1332H, TRP1375H, TRP1468H, TRP214G, TRP235G, TRP241G, TRP258G, TYR1171H, TYR1177H, TYR1191H, TYR1354H, TYR1364H, TYR191G, TYR264G, TYR43G, VAL1006H, VAL1007H, VAL1038H, VAL1057H, VAL1063H, VAL1073H, VAL1117H, VAL1119H, VAL1159H, VAL1188H, VAL1218H, VAL1219H, VAL1222H, VAL1242H, VAL1360H, VAL1539H, VAL1560H, VAL243G, VAL8G, VAL90G