3MY0

crystal structure of the acvrl1 (alk1) kinase domain bound to ldn- 193189

• Total interactions analyzed: 276
• Total true interactions: 44
• Strongest Interaction:
  • Chains: M-Q
  • Int. Res.: 75
  • Norm. En. per Res.: -2.8044
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	0.0	3.3818	-14.5919	-11.2101	24	0	0	678	0	11	8
A-D	0.0	5.3402	-49.4519	-44.1117	63	3	0	3384	0	22	21
A-E	0.0	0.0	-40.1224	-40.1224	47	2	0	2537	0	17	12
A-F	0.0	4.5892	-41.7624	-37.1732	50	4	0	2815	0	21	23
A-M	-4.4505	12.7644	-141.713	-133.399	79	8	0	5734	0	16	15
A-N	0.0	0.0	-14.061	-14.061	21	1	0	766	0	0	1
B-C	-42.5123	-10.8373	-126.145	-179.4946	84	16	1	5612	1	19	29
B-F	-23.4214	-18.6085	-122.457	-164.4869	70	8	2	5740	1	22	21
B-L	-5.934	0.0	-109.584	-115.518	74	4	0	4776	0	17	16
B-M	0.0	0.0	-0.8371	-0.8371	12	0	0	177	0	8	5
C-G	0.0	19.0718	-39.4186	-20.3468	49	3	0	2454	0	20	16
C-H	0.0	-2.4916	-44.3024	-46.794	59	1	0	2813	0	22	20
C-L	0.0	0.0	-22.5712	-22.5712	22	1	0	935	0	1	1
D-F	-3.2307	0.0	-25.5765	-28.8072	35	2	0	1070	0	17	13
D-I	-37.234	5.7391	-132.362	-163.8569	93	13	3	6959	2	21	34
E-K	0.0	0.0	-11.1294	-11.1294	28	0	0	752	0	8	12
E-V	-13.7802	13.1784	-71.5066	-72.1083	68	3	0	3212	0	14	14
F-J	0.0	-8.3074	-56.4369	-64.7443	53	13	0	3437	0	19	20
G-H	-12.6553	-10.1522	-24.7366	-47.5441	38	4	0	1471	0	5	10
G-I	-19.5562	-17.7705	-151.184	-188.5106	71	16	2	6855	0	20	20
G-K	0.0	-28.8898	-34.8876	-63.7774	45	5	0	1680	3	26	23
H-I	-7.5569	5.1649	-15.5328	-17.9249	34	6	0	1239	0	11	11
H-W	-7.5027	0.0	-0.0007	-7.5034	4	0	0	2	0	3	1
J-W	0.0	10.226	-32.7471	-22.5211	45	0	0	2004	0	14	22
K-P	-2.76	12.7336	-83.4878	-73.5142	60	0	0	3319	0	16	14
K-V	0.0	0.0	-11.0322	-11.0322	16	0	1	560	0	2	6
L-M	0.0	0.0	-7.6593	-7.6593	21	0	0	582	0	10	7
L-O	0.0	-12.3651	-62.6157	-74.9808	61	1	0	3633	2	22	20
L-P	-5.388	0.0	-56.1022	-61.4902	57	14	0	3431	0	21	17
L-Q	-17.6388	28.1657	-66.1724	-55.6455	50	7	0	3288	0	20	20
M-N	-59.3569	-20.7827	-115.797	-195.9366	90	17	1	5567	2	17	30
M-Q	-30.2325	-18.2438	-161.853	-210.3293	75	12	3	6519	0	21	20
N-R	-7.4315	20.7102	-47.0144	-33.7357	52	9	0	2911	0	20	18
N-S	0.0	-1.019	-37.4593	-38.4783	55	3	0	2699	0	22	19
O-Q	0.0	4.4612	-27.2731	-22.8119	34	1	0	1113	0	15	15
O-T	-58.3006	13.1361	-156.571	-201.7355	91	18	3	7039	2	19	27
P-V	-4.0127	0.0	-15.6387	-19.6514	21	2	0	755	0	8	10
Q-U	-4.1814	0.0	-45.0081	-49.1895	52	3	0	2293	0	16	14
R-S	0.0	-21.0465	-26.6705	-47.717	42	1	0	1764	1	5	11
R-T	-28.8881	-7.7367	-174.01	-210.6347	78	9	3	7132	0	20	21
R-V	0.0	-5.5526	-25.4836	-31.0361	37	1	0	1060	1	19	16
S-T	0.0	8.5726	-28.4447	-19.8721	34	3	0	1359	0	12	13
S-X	0.0	8.1923			2
U-X	0.0	7.3169			3

Interface residues

• A-B: ARG212B, ARG422B, ASN431B, ASP432B, CYS207A, GLN272A, GLU215A, GLY211B, GLY214A, ILE230A, LEU204A, LYS210A, LYS210B, LYS373B, PHE231A, PRO430B, PRO433B, SER232A, SER233A, SER270A, SER434B, THR271A, TRP217A, VAL429B
• A-D: ALA456A, ALA456D, ALA457A, ALA457D, ARG410A, ARG410D, ARG422A, ARG422D, ARG454A, ARG454D, ASN415A, ASN415D, ASN431A, ASN431D, ASN453A, ASN453D, ASP420A, ASP420D, ASP427A, ASP427D, ASP437A, ASP437D, ASP445A, ASP445D, ASP458A, GLN446D, GLN447A, GLN447D, GLU419A, GLU419D, GLY416A, GLY416D, ILE417A, ILE417D, ILE451A, ILE451D, LEU455A, LEU455D, LYS440A, LYS440D, PHE425A, PHE425D, PRO430A, PRO430D, PRO449D, PRO452A, PRO452D, THR448D, THR450A, THR450D, TYR421D, TYR426A, TYR426D, VAL414A, VAL414D, VAL418A, VAL418D, VAL428A, VAL428D, VAL429A, VAL429D, VAL441A, VAL441D
• A-E: ALA377A, ALA478A, ALA478E, ARG386A, ARG386E, ARG479A, ARG479E, ARG484E, ASN475A, ASN475E, ASP382A, ASP382E, ASP388E, ASP445A, CYS389A, CYS389E, CYS443A, CYS443E, GLN384A, GLN384E, GLN446A, GLN446E, GLU379A, GLU379E, GLU383A, GLU383E, GLU470E, ILE385E, LEU480E, PRO378A, PRO378E, PRO474A, PRO474E, PRO476A, PRO476E, SER392E, SER477A, SER477E, THR387E, TRP395A, TRP395E, TYR473A, TYR473E, VAL380A, VAL442A, VAL442E, VAL444A
• A-F: ARG218A, ARG218F, ARG291A, ARG291F, ARG411F, ASN415A, ASN415F, ASP287A, ASP287F, CYS207A, CYS207F, GLN290A, GLN290F, GLN292A, GLN292F, GLU206A, GLU206F, GLU281A, GLU281F, GLU295A, GLU295F, GLY416A, GLY416F, HIS282A, HIS282F, ILE413A, ILE413F, ILE417A, ILE417F, LEU204A, LEU204F, LEU294A, LEU294F, PHE288A, PHE288F, PRO296A, THR293A, THR293F, TRP217A, TRP217F, TYR279A, TYR279F, VAL205A, VAL205F, VAL208A, VAL208F, VAL414A, VAL414F, VAL418A, VAL418F
• A-M: ALA199A, ALA199M, ALA261M, ARG196A, ARG196M, ARG200A, ARG200M, ARG234A, ARG234M, ARG241A, ARG241M, ARG267M, ASN247A, ASN247M, ASN366A, ASN366M, ASN367A, ASN367M, ASP235A, ASP263A, ASP263M, ASP363A, ASP363M, GLN195A, GLN195M, GLN201M, GLN237A, GLN237M, GLN272A, GLN272M, GLU236A, GLU236M, GLU244A, GLU244M, GLY365A, GLY365M, ILE364A, ILE364M, LEU273A, LEU273M, LEU362A, LEU362M, MET0A, MET0M, MET264A, MET264M, MET354A, MET354M, PHE240A, PHE240M, PHE259M, PRO368A, SER233A, SER233M, SER238A, SER238M, SER262A, SER262M, SER266M, SER270A, SER359A, THR197A, THR197M, THR243A, THR243M, THR248A, THR248M, THR265A, THR265M, THR271A, THR271M, TRP239A, TRP239M, TRP274A, TRP274M, TYR361A, TYR361M, VAL198A, VAL198M
• A-N: ASN247A, ASN247N, ASP360A, ASP360N, GLN357A, GLN357N, GLU244A, GLU244N, GLY319A, GLY358A, GLY358N, HIS355N, SER356N, SER359A, SER359N, THR248A, THR248N, THR320A, THR320N, TYR361A, TYR361N
• B-C: ALA261B, ALA261C, ARG252B, ARG252C, ARG301B, ARG301C, ASN247B, ASN247C, ASN255B, ASN341B, ASN341C, ASN494B, ASP254B, ASP254C, CYS308C, GLN195B, GLN195C, GLN321B, GLN321C, GLN343B, GLN343C, GLN357C, GLN490B, GLN490C, GLU224C, GLU244B, GLU244C, GLU295C, GLY258B, GLY319B, GLY319C, GLY322B, GLY322C, HIS253B, HIS253C, HIS278B, HIS278C, HIS297B, HIS297C, HIS312B, HIS312C, ILE245B, ILE245C, ILE260B, ILE260C, ILE317B, ILE317C, ILE326B, ILE492C, LEU250B, LEU250C, LEU251B, LEU251C, LEU342B, LEU489C, LYS323B, LYS323C, LYS339B, LYS486B, LYS486C, LYS487B, LYS487C, LYS491C, MET0C, PHE259B, PHE259C, PHE318B, PHE318C, PRO324B, SER340B, SER493B, THR243B, THR248B, THR248C, THR320B, THR320C, TRP221B, TYR246B, TYR246C, VAL198B, VAL249B, VAL249C, VAL304C, VAL315C
• B-F: ALA456B, ALA456F, ALA457B, ALA457F, ARG410B, ARG410F, ARG422B, ARG422F, ARG454B, ARG454F, ASN415B, ASN415F, ASN431B, ASN431F, ASN453B, ASN453F, ASP420B, ASP420F, ASP427B, ASP427F, ASP437B, ASP437F, ASP445B, ASP445F, ASP458F, GLN446B, GLN446F, GLN447B, GLN447F, GLU419B, GLU419F, GLY416B, GLY416F, ILE413F, ILE417B, ILE417F, ILE451B, ILE451F, LEU455B, LEU455F, LYS440B, LYS440F, PHE425B, PHE425F, PRO430B, PRO430F, PRO433B, PRO449B, PRO449F, PRO452B, PRO452F, THR412F, THR448B, THR448F, THR450B, THR450F, TRP406B, TYR426B, TYR426F, VAL414B, VAL414F, VAL418B, VAL418F, VAL428B, VAL428F, VAL429B, VAL429F, VAL441B, VAL441F, VAL444B
• B-L: ALA199B, ALA261B, ARG196B, ARG196L, ARG200B, ARG200L, ARG234B, ARG234L, ARG241B, ARG241L, ASN247B, ASN247L, ASN366B, ASN366L, ASN367L, ASP235L, ASP263B, ASP263L, ASP363B, ASP363L, GLN195B, GLN195L, GLN201B, GLN201L, GLN237B, GLN237L, GLN272B, GLN272L, GLU236B, GLU236L, GLU244B, GLU244L, GLY365B, GLY365L, ILE364B, ILE364L, LEU273B, LEU273L, LEU362B, LEU362L, MET0L, MET264B, MET264L, MET354L, PHE240B, PHE240L, PHE259B, PRO368B, PRO368L, SER233B, SER233L, SER238B, SER238L, SER262B, SER262L, SER270L, THR197B, THR197L, THR243B, THR243L, THR248B, THR248L, THR265B, THR265L, THR271B, THR271L, TRP239B, TRP239L, TRP274B, TRP274L, TYR361B, TYR361L, VAL198B, VAL198L
• B-M: ARG212B, ARG212M, ARG234B, ARG234M, GLN272B, GLN272M, LYS210M, SER232B, SER232M, SER233B, SER233M, THR271B
• C-G: ALA478C, ALA478G, ARG386C, ARG386G, ARG469C, ARG479C, ASN475C, ASN475G, ASP360G, ASP382C, ASP382G, ASP388G, ASP445C, CYS389G, CYS443C, GLN357G, GLN384C, GLN384G, GLN446C, GLN446G, GLN447C, GLN466C, GLU379C, GLU379G, GLU383G, GLU391G, GLU470C, HIS355G, ILE385C, ILE385G, ILE451C, LYS394G, LYS439C, PHE390G, PRO378C, PRO474C, PRO474G, PRO476C, PRO476G, SER392G, SER477G, THR387G, THR448C, THR450C, TRP395G, TRP472C, TYR473C, VAL442C, VAL444C
• C-H: ALA456C, ALA456H, ALA457C, ALA457H, ARG410C, ARG410H, ARG422C, ARG422H, ARG454C, ARG454H, ASN415C, ASN415H, ASN431C, ASN431H, ASN453C, ASN453H, ASP420C, ASP420H, ASP427C, ASP427H, ASP437H, ASP445C, ASP445H, ASP458C, GLN447C, GLN447H, GLU419C, GLU419H, GLY416C, GLY416H, ILE417C, ILE417H, ILE451H, LEU455C, LEU455H, LYS440C, LYS440H, PHE425H, PRO423C, PRO430C, PRO430H, PRO452C, PRO452H, THR448H, THR450C, THR450H, TYR426C, TYR426H, VAL414C, VAL414H, VAL418C, VAL418H, VAL428C, VAL428H, VAL429C, VAL429H, VAL441C, VAL441H, VAL444H
• C-L: ASN247C, ASN247L, ASP360C, ASP360L, GLN357C, GLN357L, GLU244C, GLU244L, GLY319L, GLY358C, GLY358L, HIS355L, SER356C, SER356L, SER359C, SER359L, THR248C, THR248L, THR320C, THR320L, TYR361C, TYR361L
• D-F: ARG212D, ARG234F, ARG291D, ARG334D, ASN431D, ASP235F, ASP432D, ASP432F, CYS207D, CYS207F, GLN237F, GLN272F, GLN290D, GLU215D, GLU215F, GLU236F, GLY209D, GLY211D, GLY211F, GLY214D, ILE230F, LEU204F, LYS210D, LYS210F, PRO368F, PRO430D, SER232F, SER233F, TRP217D, TRP217F, TRP274F, TYR213D, TYR286D, VAL208D, VAL216D
• D-I: ALA261D, ALA261I, ALA311D, ARG196I, ARG252D, ARG252I, ARG301D, ARG301I, ASN247D, ASN247I, ASN255D, ASN255I, ASN341D, ASN341I, ASP254D, ASP254I, CYS308D, GLN195D, GLN195I, GLN321D, GLN321I, GLN343D, GLN343I, GLN357D, GLN490D, GLN490I, GLU224I, GLU244I, GLU316D, GLY258I, GLY319D, GLY319I, GLY322D, GLY322I, GLY358D, HIS222I, HIS253D, HIS253I, HIS278D, HIS278I, HIS280I, HIS297D, HIS297I, HIS312D, HIS312I, ILE245D, ILE245I, ILE256D, ILE256I, ILE260D, ILE260I, ILE317D, ILE317I, ILE326I, LEU250D, LEU250I, LEU251D, LEU251I, LEU342I, LEU483D, LEU489D, LYS323D, LYS323I, LYS339I, LYS486D, LYS486I, LYS487D, LYS491D, MET0D, MET0I, PHE259D, PHE259I, PHE318D, PHE318I, SER262I, SER340I, SER356D, SER493I, THR197I, THR248D, THR248I, THR320D, THR320I, THR488D, TRP221I, TYR246D, TYR246I, VAL198I, VAL249D, VAL249I, VAL304D, VAL315D, VAL315I
• E-K: ARG252E, ARG252K, ASN255K, ASN341K, ASP254E, ASP254K, CYS308K, GLN321E, GLN490K, GLY319E, GLY322E, HIS253K, HIS278E, HIS278K, ILE256K, ILE260E, ILE492K, LEU250E, LEU483K, LYS339K, LYS487K, LYS491K, MET0E, PHE318E, SER305K, THR320E, TRP221E, VAL304K
• E-V: ALA199V, ALA261V, ARG196E, ARG196V, ARG200E, ARG200V, ARG234E, ARG241E, ARG241V, ASN247E, ASN247V, ASN366E, ASN366V, ASN367E, ASP235E, ASP263E, ASP263V, ASP363E, ASP363V, GLN195E, GLN195V, GLN237E, GLN237V, GLN272V, GLU236E, GLU236V, GLU244E, GLU244V, GLY365E, GLY365V, HIS222V, ILE364E, ILE364V, LEU273E, LEU273V, LEU362E, MET0E, MET0V, MET264E, MET264V, MET354E, PHE240E, PHE240V, PHE259V, PRO368E, PRO368V, SER233E, SER233V, SER238E, SER262E, SER262V, SER359E, THR197E, THR197V, THR243E, THR243V, THR248E, THR248V, THR265V, THR271E, THR271V, TRP221V, TRP239E, TRP239V, TRP274E, TRP274V, TYR361E, VAL198V
• F-J: ALA478F, ALA478J, ARG386F, ARG386J, ARG469F, ARG479F, ARG479J, ARG484F, ASN475F, ASN475J, ASP382F, ASP382J, ASP388J, ASP445J, CYS389J, CYS443F, CYS443J, GLN384F, GLN384J, GLN446F, GLN446J, GLN466F, GLU379F, GLU379J, GLU383F, GLU383J, GLU470F, ILE385F, ILE385J, LEU381J, LEU480F, LYS439J, PRO378F, PRO378J, PRO474F, PRO474J, PRO476F, PRO476J, SER392F, SER392J, SER477F, SER477J, THR387J, TRP395F, TRP395J, TRP472F, TYR473F, TYR473J, VAL380J, VAL442F, VAL442J, VAL444F, VAL444J
• G-H: ALA456G, ALA457G, ALA465H, ALA478G, ALA478H, ARG469G, ARG469H, ARG479G, ARG484G, ARG484H, ASN453G, ASN475H, GLN446H, GLN466G, GLN466H, GLU470G, GLU470H, GLY463G, GLY463H, LEU455G, LEU464H, LEU480G, LEU480H, LYS491G, MET467G, MET467H, PRO474H, SER462G, SER462H, SER477G, SER477H, THR448H, THR481G, THR488G, THR488H, TRP472H, TYR473G, TYR473H
• G-I: ALA456G, ALA456I, ALA457G, ALA457I, ARG410G, ARG410I, ARG422G, ARG422I, ARG454G, ARG454I, ASN415G, ASN415I, ASN431G, ASN453G, ASN453I, ASP420G, ASP420I, ASP427G, ASP427I, ASP437G, ASP437I, ASP445G, ASP445I, ASP458G, ASP458I, GLN446G, GLN446I, GLN447G, GLN447I, GLU419G, GLU419I, GLY416G, GLY416I, ILE413G, ILE417G, ILE417I, ILE451G, ILE451I, LEU455G, LEU455I, LYS440G, LYS440I, PHE425G, PHE425I, PRO430G, PRO430I, PRO449G, PRO449I, PRO452G, PRO452I, THR448G, THR448I, THR450G, THR450I, TRP406I, TRP472G, TRP472I, TYR426G, TYR426I, VAL414G, VAL414I, VAL418G, VAL418I, VAL428G, VAL428I, VAL429G, VAL429I, VAL441G, VAL441I, VAL444G, VAL444I
• G-K: ARG212K, ARG234G, ARG291K, ARG374K, ASN431G, ASN431K, ASP235G, ASP432G, ASP432K, CYS207G, CYS207K, GLN272G, GLN290K, GLU206G, GLU206K, GLU215G, GLU215K, GLU236G, GLY209G, GLY209K, GLY211G, GLY211K, GLY214K, ILE230G, LEU204G, LYS210G, LYS210K, PRO368G, PRO423K, PRO430G, PRO430K, PRO433G, PRO433K, SER232G, SER233G, SER434G, TRP217G, TRP217K, TRP274G, TYR213K, TYR286K, VAL205G, VAL208K, VAL216K, VAL429K
• H-I: ALA478I, ARG386H, ARG469I, ASN475H, ASN475I, ASP382H, ASP382I, ASP388H, ASP445I, CYS443H, CYS443I, GLN384H, GLN384I, GLN446H, GLN446I, GLN447I, GLN466I, GLU379H, GLU383H, ILE385H, LYS439H, PRO378I, PRO474I, PRO476H, PRO476I, SER477H, SER477I, THR387H, TRP395H, TRP472I, TYR473I, VAL442I, VAL444H, VAL444I
• H-W: ASN431W, GLU215H, LYS210W, SER233H
• J-W: ALA311J, ALA311W, ARG252J, ARG252W, ARG301W, ASN247J, ASN255J, ASN255W, ASN341W, ASP254J, ASP254W, CYS308J, CYS308W, GLN343W, GLN490J, GLU295W, GLU316J, HIS253J, HIS253W, HIS297W, HIS312J, HIS312W, ILE256W, ILE317W, ILE326J, LEU250J, LEU250W, LEU251J, LEU298W, LEU300W, LEU342W, LEU483J, LYS339W, LYS486J, LYS486W, LYS487J, LYS491W, PRO324J, SER305W, SER340W, THR248J, VAL249J, VAL304J, VAL304W, VAL315J
• K-P: ALA199K, ALA261K, ARG196K, ARG196P, ARG200K, ARG200P, ARG241K, ARG241P, ASN247K, ASN247P, ASN366K, ASN366P, ASN367P, ASP235P, ASP263K, ASP263P, ASP363K, ASP363P, GLN195K, GLN195P, GLN201K, GLN237K, GLN237P, GLN272K, GLN272P, GLU236K, GLU236P, GLU244K, GLU244P, GLY365K, GLY365P, ILE364K, ILE364P, LEU273K, LEU273P, LEU362P, MET264K, MET264P, MET354P, PHE240K, PHE240P, PHE259K, PRO368P, SER238P, SER262K, SER262P, THR197K, THR197P, THR243K, THR243P, THR248K, THR248P, THR265K, THR271K, TRP239K, TRP239P, TRP274K, TRP274P, TYR361P, VAL198K
• K-V: ALA325V, GLU316K, GLU316V, ILE317K, ILE317V, LEU250K, LEU250V, LYS323K, LYS323V, MET354V, PRO324K, PRO324V, THR248K, THR248V, VAL249K, VAL249V
• L-M: ARG212M, ARG422M, ASN431M, ASP432M, CYS207L, GLN272L, GLU215L, GLY211M, GLY214L, ILE230L, LEU204L, LYS210L, LYS210M, PHE231L, PRO430M, SER232L, SER233L, SER270L, THR271L, TRP217L, VAL429M
• L-O: ALA456L, ALA456O, ALA457L, ALA457O, ARG410L, ARG410O, ARG411O, ARG422L, ARG422O, ARG454L, ARG454O, ASN415L, ASN415O, ASN431L, ASN431O, ASN453L, ASN453O, ASP420L, ASP420O, ASP427L, ASP427O, ASP437L, ASP437O, ASP445L, ASP445O, GLN447L, GLN447O, GLU419L, GLU419O, GLY416L, GLY416O, ILE417L, ILE417O, ILE451L, ILE451O, LEU455O, LYS440L, LYS440O, PHE425L, PHE425O, PRO430L, PRO430O, PRO433L, PRO452L, PRO452O, THR448O, THR450L, THR450O, TYR421O, TYR426L, TYR426O, VAL414L, VAL414O, VAL418L, VAL418O, VAL428L, VAL428O, VAL429L, VAL429O, VAL441L, VAL441O
• L-P: ALA478L, ALA478P, ARG386L, ARG386P, ARG469P, ARG479L, ARG479P, ASN475L, ASN475P, ASP382L, ASP382P, ASP388L, ASP388P, ASP445L, CYS389P, CYS443L, CYS443P, GLN384L, GLN384P, GLN446L, GLN446P, GLU379L, GLU379P, GLU383L, GLU383P, GLU391P, GLU470L, GLU470P, ILE385L, ILE385P, LEU381L, LEU480P, LYS439L, PRO378L, PRO378P, PRO474L, PRO474P, PRO476L, PRO476P, SER392L, SER392P, SER477L, SER477P, THR387L, THR387P, TRP395L, TRP395P, TRP399L, TRP472L, TRP472P, TYR473L, TYR473P, VAL380L, VAL442L, VAL442P, VAL444L, VAL444P
• L-Q: ARG218L, ARG218Q, ARG291L, ARG291Q, ARG411L, ARG411Q, ASN415L, ASN415Q, ASP287L, ASP287Q, CYS207L, CYS207Q, GLN290L, GLN290Q, GLN292L, GLN292Q, GLU206L, GLU206Q, GLU281L, GLU281Q, GLU295L, GLU295Q, GLY416L, GLY416Q, HIS282L, HIS282Q, ILE413L, ILE413Q, ILE417L, ILE417Q, LEU204L, LEU204Q, LEU294L, LEU294Q, PHE288L, PHE288Q, PRO296Q, THR293L, THR293Q, THR412Q, TRP217L, TRP217Q, TYR279Q, VAL205L, VAL205Q, VAL208L, VAL208Q, VAL414Q, VAL418L, VAL418Q
• M-N: ALA261M, ALA261N, ARG252M, ARG252N, ARG301M, ARG301N, ASN247M, ASN247N, ASN255M, ASN341M, ASN341N, ASN494M, ASP254M, ASP254N, CYS308N, GLN195M, GLN195N, GLN321M, GLN321N, GLN343M, GLN343N, GLN357N, GLN490M, GLN490N, GLU244M, GLU244N, GLU316N, GLY258M, GLY258N, GLY319M, GLY319N, GLY322M, GLY322N, GLY358N, HIS253M, HIS253N, HIS278M, HIS278N, HIS297M, HIS297N, HIS312M, HIS312N, ILE245M, ILE245N, ILE260M, ILE260N, ILE317M, ILE317N, ILE326M, ILE492N, LEU250M, LEU250N, LEU251M, LEU251N, LEU300N, LEU489N, LYS323M, LYS323N, LYS339M, LYS486M, LYS486N, LYS487M, LYS487N, LYS491M, LYS491N, MET0M, MET0N, PHE259M, PHE259N, PHE318M, PHE318N, PRO324M, SER340M, SER356N, SER493M, SER493N, THR248M, THR248N, THR320M, THR320N, TRP221M, TRP221N, TYR246M, TYR246N, VAL198M, VAL198N, VAL249M, VAL249N, VAL315M, VAL315N
• M-Q: ALA456M, ALA456Q, ALA457M, ALA457Q, ARG374M, ARG374Q, ARG410M, ARG410Q, ARG422M, ARG422Q, ARG454M, ARG454Q, ASN415M, ASN415Q, ASN431M, ASN431Q, ASN453M, ASN453Q, ASP420M, ASP420Q, ASP427M, ASP427Q, ASP437M, ASP437Q, ASP445M, ASP445Q, ASP458M, ASP458Q, GLN446M, GLN446Q, GLN447M, GLN447Q, GLU419M, GLU419Q, GLY416M, GLY416Q, ILE413Q, ILE417M, ILE417Q, ILE451M, ILE451Q, LEU455M, LEU455Q, LYS440M, LYS440Q, MET438M, PHE425M, PHE425Q, PRO430M, PRO430Q, PRO449M, PRO449Q, PRO452M, PRO452Q, THR448M, THR448Q, THR450M, THR450Q, TRP406M, TRP406Q, TRP472M, TYR426M, TYR426Q, VAL414M, VAL414Q, VAL418M, VAL418Q, VAL428M, VAL428Q, VAL429M, VAL429Q, VAL441M, VAL441Q, VAL444M, VAL444Q
• N-R: ALA478N, ALA478R, ARG386R, ARG469N, ARG479N, ASN475N, ASN475R, ASP360R, ASP382N, ASP382R, ASP388R, ASP445N, CYS389R, CYS443N, GLN357R, GLN384N, GLN384R, GLN446N, GLN446R, GLN447N, GLN466N, GLU379N, GLU379R, GLU383R, GLU391R, GLU470N, HIS355R, ILE385N, ILE385R, ILE451N, LYS394R, LYS439N, PHE390R, PRO378N, PRO449N, PRO474N, PRO474R, PRO476N, PRO476R, SER392R, SER477N, SER477R, THR387R, THR448N, THR450N, TRP395R, TRP472N, TYR393R, TYR473N, VAL441N, VAL442N, VAL444N
• N-S: ALA456N, ALA456S, ALA457N, ALA457S, ARG410N, ARG410S, ARG422N, ARG422S, ARG454N, ARG454S, ASN415N, ASN415S, ASN431N, ASN431S, ASN453N, ASN453S, ASP420N, ASP420S, ASP427N, ASP427S, ASP437S, ASP445N, ASP445S, GLN447N, GLN447S, GLU419N, GLU419S, GLY416N, GLY416S, ILE417N, ILE417S, ILE451N, ILE451S, LEU455N, LEU455S, LYS440N, LYS440S, PHE425S, PRO430N, PRO430S, PRO452N, PRO452S, THR450N, THR450S, TYR426N, TYR426S, VAL414N, VAL414S, VAL418N, VAL428N, VAL428S, VAL429N, VAL429S, VAL441N, VAL441S
• O-Q: ARG212O, ARG234Q, ARG291O, ARG334O, ASN431O, ASP235Q, ASP432O, ASP432Q, CYS207O, CYS207Q, GLN237Q, GLN272Q, GLN290O, GLU215O, GLU215Q, GLU236Q, GLY209O, GLY209Q, GLY211O, GLY211Q, GLY214O, ILE230Q, LYS210O, LYS210Q, PRO368Q, PRO430O, SER232Q, SER233Q, TRP217O, TRP217Q, TYR213O, TYR286O, VAL208O, VAL216O
• O-T: ALA261O, ALA261T, ARG196T, ARG252O, ARG252T, ARG301O, ARG301T, ASN247O, ASN247T, ASN255O, ASN255T, ASN341O, ASN341T, ASP254O, ASP254T, CYS308O, GLN195O, GLN195T, GLN321O, GLN321T, GLN343O, GLN343T, GLN357O, GLN490O, GLN490T, GLU224T, GLU244T, GLU316O, GLU316T, GLY258O, GLY258T, GLY319O, GLY319T, GLY322O, GLY322T, GLY358O, HIS222T, HIS253O, HIS253T, HIS278O, HIS278T, HIS280T, HIS297O, HIS312O, HIS312T, ILE245O, ILE245T, ILE256O, ILE260O, ILE260T, ILE317O, ILE317T, ILE326T, LEU250O, LEU250T, LEU251O, LEU251T, LEU342T, LEU483O, LEU489O, LYS323O, LYS323T, LYS339T, LYS486O, LYS486T, LYS487O, MET0O, MET0T, PHE259O, PHE259T, PHE318O, PHE318T, PRO324O, PRO324T, SER262T, SER340T, THR243T, THR248O, THR248T, THR320O, THR320T, THR488O, TYR246O, TYR246T, VAL198O, VAL198T, VAL249O, VAL249T, VAL304O, VAL315O, VAL315T
• P-V: ARG252P, ARG252V, ASN255V, ASN341V, ASP254P, ASP254V, CYS308V, GLN321P, GLN490V, GLY322P, HIS253V, HIS278V, LEU250P, LYS339V, LYS486V, LYS487V, LYS491V, SER493V, THR320P, VAL198P, VAL304V
• Q-U: ALA377U, ALA478Q, ALA478U, ARG386Q, ARG386U, ARG469Q, ARG479Q, ARG479U, ARG484Q, ASN475Q, ASN475U, ASP382Q, ASP382U, ASP388U, ASP445U, CYS389Q, CYS389U, CYS443Q, CYS443U, GLN384Q, GLN384U, GLN446Q, GLN446U, GLN466Q, GLU379Q, GLU379U, GLU383U, GLU391U, GLU470Q, ILE385U, LEU381U, LEU480Q, LYS439U, PRO378Q, PRO378U, PRO474Q, PRO474U, PRO476Q, PRO476U, SER392U, SER477Q, SER477U, THR387U, TRP395Q, TRP395U, TRP472Q, TYR473Q, TYR473U, VAL380U, VAL442Q, VAL442U, VAL444U
• R-S: ALA456R, ALA456S, ALA457R, ALA465R, ALA465S, ALA478R, ALA478S, ARG386S, ARG469R, ARG469S, ARG479R, ARG484R, ARG484S, ASN453R, ASN475S, ASP458R, GLN446S, GLN466R, GLN466S, GLU470R, GLU470S, GLY463R, GLY463S, LEU455R, LEU480R, LEU480S, LYS491R, MET467R, MET467S, PRO459R, PRO474S, PRO476S, SER462R, SER462S, SER477S, THR448S, THR481R, THR488R, THR488S, TRP472S, TYR473R, TYR473S
• R-T: ALA456R, ALA456T, ALA457R, ALA457T, ARG374R, ARG410R, ARG410T, ARG422R, ARG422T, ARG454R, ARG454T, ARG469R, ARG469T, ASN415R, ASN415T, ASN431R, ASN431T, ASN453R, ASN453T, ASP420R, ASP420T, ASP427R, ASP427T, ASP437R, ASP437T, ASP445R, ASP445T, ASP458R, ASP458T, GLN446R, GLN446T, GLN447R, GLN447T, GLU419R, GLU419T, GLY416R, GLY416T, ILE413R, ILE417R, ILE417T, ILE451R, ILE451T, LEU455R, LEU455T, LYS440R, LYS440T, MET438T, PHE425R, PHE425T, PRO430R, PRO430T, PRO449R, PRO449T, PRO452R, PRO452T, THR448R, THR448T, THR450R, THR450T, TRP406R, TRP406T, TRP472R, TRP472T, TYR426R, TYR426T, VAL414R, VAL414T, VAL418R, VAL418T, VAL428R, VAL428T, VAL429R, VAL429T, VAL441R, VAL441T, VAL442T, VAL444R, VAL444T
• R-V: ARG212V, ARG234R, ARG291V, ARG374V, ASN431R, ASN431V, ASP235R, ASP432R, ASP432V, CYS207R, CYS207V, GLN272R, GLN290V, GLU206V, GLU215R, GLU215V, GLU236R, GLY209V, GLY211R, GLY211V, GLY214V, ILE230R, LEU204R, LYS210R, LYS210V, PRO368R, PRO430R, PRO430V, PRO433R, SER232R, SER233R, SER434R, TRP217R, TRP217V, TYR213V, VAL208V, VAL429V
• S-T: ALA478T, ARG386S, ARG469T, ASN475S, ASN475T, ASP382S, ASP382T, ASP388S, ASP445T, CYS389S, CYS443S, CYS443T, GLN384S, GLN384T, GLN446T, GLN447T, GLN466T, GLU379S, GLU383S, GLU470T, ILE385S, LYS439S, PRO378T, PRO474T, PRO476S, SER392S, THR387S, TRP395S, TRP472T, TYR473T, VAL441T, VAL442T, VAL444S, VAL444T
• S-X: ASP432X, GLU215S
• U-X: ARG252U, HIS312X, LYS486X