3MX0

crystal structure of epha2 ectodomain in complex with ephrin-a5

• Total interactions analyzed: 6
• Total true interactions: 5
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 91
  • Norm. En. per Res.: -2.5016
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-33.1397	-10.1643	-184.344	-227.648	91	48	3	9689	2	11	14
A-C	-8.1629	14.7285	-102.554	-95.9884	61	4	3	4683	0	12	9
A-D	-14.6043	0.0	-5.7226	-20.3269	15	5	0	663	0	3	5
B-C	-8.5607	0.0	-7.6284	-16.1891	15	6	0	609	0	2	5
C-D	-27.9529	-2.192	-185.197	-215.3418	93	32	3	9774	0	13	13

Interface residues

• A-B: ALA158A, ALA187A, ALA190A, ARG103A, ARG104B, ARG131B, ARG159A, ARG31B, ARG99B, ASN103B, ASN109B, ASN55B, ASN57A, ASN60A, ASN71A, ASP104A, ASP155A, ASP53A, ASP59B, ASP61A, CYS105A, CYS188A, CYS70A, GLN119B, GLN56A, GLU101B, GLU116B, GLU129B, GLU157A, GLU40A, GLY110A, GLY111A, GLY127B, GLY49A, GLY51A, HIS160A, ILE58A, ILE64A, LEU112B, LEU120B, LEU126B, LEU163A, LEU191A, LEU192A, LEU54A, LEU79B, LYS113B, LYS117B, LYS162A, LYS50A, LYS98B, LYS99A, MET55A, MET59A, MET62A, MET66A, MET73A, PHE100A, PHE108A, PHE114B, PHE121B, PHE124B, PHE128B, PHE156A, PHE97B, PRO109A, PRO123B, PRO63A, SER107A, SER115B, SER125B, SER153A, SER154A, SER193A, SER68A, SER74A, THR101A, THR122B, THR151A, TRP100B, TRP52A, TYR57B, TYR65A, TYR67A, VAL102A, VAL152A, VAL161A, VAL189A, VAL60B, VAL69A, VAL72A
• A-C: ALA36C, ALA37A, ALA37C, ARG137A, ARG82A, ARG82C, ASN133A, ASN133C, ASN84A, ASN84C, ASP129A, ASP129C, ASP53C, GLN135A, GLU40A, GLU40C, GLY131A, GLY131C, GLY38C, GLY39A, GLY39C, GLY42A, GLY42C, GLY49A, GLY49C, LEU128A, LEU128C, LEU138A, LEU32C, LEU41A, LEU41C, LEU44A, LEU44C, LEU54A, LEU54C, LYS176C, LYS50A, PHE134A, PHE134C, THR132A, THR132C, THR45A, THR45C, THR83A, THR83C, TRP43A, TRP43C, TRP85A, TRP85C, TYR130A, TYR130C, TYR179A, TYR179C, TYR48A, TYR48C, TYR67A, TYR67C, TYR87A, TYR87C, VAL86A, VAL86C
• A-D: ARG137A, ARG31D, ASN109D, ASN133A, GLN135A, GLY110D, HIS64D, LEU128A, LEU138A, LYS113D, PRO108D, PRO111D, SER107D, TYR130A, TYR48A
• B-C: ARG137C, ASN109B, ASN133C, ASP30B, GLN135C, GLY110B, HIS64B, LEU138C, LYS113B, PHE61B, PRO108B, PRO111B, SER107B, TYR130C, TYR48C
• C-D: ALA158C, ALA187C, ALA190C, ARG103C, ARG104D, ARG131D, ARG159C, ARG31D, ARG99D, ASN103D, ASN109D, ASN55D, ASN57C, ASN60C, ASN71C, ASP104C, ASP155C, ASP53C, ASP59D, ASP61C, CYS105C, CYS115C, CYS188C, CYS70C, GLN119D, GLN56C, GLU101D, GLU116D, GLU129D, GLU157C, GLU40C, GLY110C, GLY111C, GLY127D, GLY49C, GLY51C, GLY96D, HIS160C, ILE58C, ILE64C, LEU112D, LEU120D, LEU126D, LEU163C, LEU191C, LEU192C, LEU54C, LEU79D, LYS113D, LYS117D, LYS162C, LYS50C, LYS98D, MET55C, MET59C, MET62C, MET66C, MET73C, MET81D, PHE100C, PHE108C, PHE114D, PHE118D, PHE121D, PHE124D, PHE128D, PHE156C, PHE97D, PRO108D, PRO109C, PRO123D, PRO63C, SER107C, SER115D, SER125D, SER68C, SER74C, THR101C, THR122D, THR151C, TRP100D, TRP52C, TYR57D, TYR65C, TYR67C, VAL102C, VAL152C, VAL161C, VAL189C, VAL60D, VAL69C, VAL72C, VAL78D