3MUG

crystal structure of human fab pg16, a broadly reactive and potent hiv-1 neutralizing antibody

• Total interactions analyzed: 66
• Total true interactions: 28
• Strongest Interaction:
  • Chains: E-F
  • Int. Res.: 192
  • Norm. En. per Res.: -3.2561
• Hub Node: A(7)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-39.8782	-109.572	-442.46	-591.9103	192	14	12	18629	9	31	42
A-C	-21.5409	18.01	-59.9085	-63.4394	50	2	0	2979	0	8	7
A-D	-7.1981	0.0	-56.1508	-63.3489	40	1	0	2664	0	5	3
A-E	0.0	0.0	-0.001	-0.001	2	0	0	3	0	0	0
A-F	-4.6261	-5.4082	-41.1275	-51.1618	40	7	0	2192	0	16	18
A-I	0.0	0.0	-0.2195	-0.2195	6	0	0	72	0	2	1
A-J	-15.9829	-4.2021	-45.8906	-66.0755	27	4	0	1755	0	6	4
B-C	-6.885	0.0	-54.4107	-61.2957	40	1	0	2552	0	4	3
B-D	0.0	0.0	-0.0097	-0.0097	2	0	0	7	0	0	0
B-I	-15.4857	-4.346	-50.8556	-70.6873	27	2	0	1923	0	8	4
B-J	-68.6972	10.8238	-104.258	-162.1315	55	15	1	4492	0	18	26
C-D	-42.171	-102.6073	-426.536	-571.3142	189	12	11	17996	10	30	42
C-E	0.0	0.0	-2.0089	-2.0089	14	0	0	146	0	0	1
C-F	-7.016	0.0	-48.3523	-55.3683	40	3	0	2344	0	10	10
E-F	-69.2948	-111.1366	-444.737	-625.1684	192	30	14	18669	9	35	43
E-J	-8.451	-0.4633	-95.66	-104.5743	48	2	0	3695	0	7	9
G-H	-42.9248	-111.2183	-459.247	-613.3902	194	18	11	19269	9	32	42
G-I	-32.8525	22.3502	-66.8342	-77.3365	51	5	0	3309	0	8	7
G-J	-6.7687	0.0	-51.4003	-58.169	39	0	0	2446	0	4	3
G-K	0.0	0.0	-0.001	-0.001	2	0	0	3	0	0	0
G-L	0.0	-11.0499	-32.4077	-43.4576	34	2	0	1601	0	14	13
H-I	-7.5927	0.0	-71.1672	-78.7599	41	1	0	2991	0	5	3
H-J	0.0	0.0	-0.0089	-0.0089	2	0	0	7	0	0	0
I-J	-34.1039	-101.9887	-426.388	-562.4807	190	14	10	18259	9	32	43
I-K	-18.068	0.0	-35.6469	-53.7149	35	4	0	1619	0	2	5
I-L	-22.9058	0.0	-68.3497	-91.2555	44	9	0	2828	0	10	9
J-L	0.0	0.0	-0.0736	-0.0736	6	0	0	34	0	3	2
K-L	-39.0505	-90.8747	-447.786	-577.7112	196	14	13	18605	7	38	43

Interface residues

• A-B: ALA125B, ALA127A, ALA130A, ALA138B, ALA139B, ALA174A, ALA175A, ALA176B, ALA3A, ALA43A, ALA49B, ALA93B, ALA96B, ARG222B, ARG38B, ARG54A, ARG56B, ARG94A, ARG94B, ARG96A, ASN100B, ASN128A, ASN170A, ASP101B, ASP138A, ASP146B, ASP31A, ASP50A, ASP61B, ASP85A, CYS134A, CYS142B, CYS88A, CYS92B, GLN126A, GLN167A, GLN179B, GLN37A, GLN38A, GLN39B, GLN6A, GLU123A, GLU124A, GLU160A, GLU46B, GLU6B, GLU95B, GLY100A, GLY101A, GLY104B, GLY106B, GLY141B, GLY158A, GLY169B, GLY33B, GLY41A, GLY42B, GLY44B, GLY99A, HIS100B, HIS172B, HIS35B, HIS53A, HIS59B, HIS95A, ILE136A, ILE58A, ILE97A, LEU117A, LEU124B, LEU125A, LEU132A, LEU135A, LEU140B, LEU143B, LEU178B, LEU179A, LEU181A, LEU187B, LEU45B, LEU4B, LEU50B, LEU91A, LYS105B, LYS117B, LYS129A, LYS129B, LYS145B, LYS166A, LYS172A, LYS207A, LYS221B, LYS228B, LYS42A, LYS43B, LYS45A, LYS57B, MET100B, MET47A, MET63B, MET89B, PHE118A, PHE122B, PHE139A, PHE174B, PHE30A, PHE49A, PHE87A, PHE91B, PHE98A, PRO119A, PRO120A, PRO123B, PRO126B, PRO164A, PRO175B, PRO41B, PRO44A, PRO55A, SER114A, SER120B, SER121A, SER122A, SER127B, SER128B, SER130B, SER134B, SER137A, SER165A, SER168A, SER168B, SER176A, SER177A, SER180A, SER180B, SER182B, SER186B, SER188B, SER189B, SER232B, SER2A, SER32A, SER34A, SER56A, SER60B, SER62B, SER89A, SER90A, SER95A, THR102A, THR116A, THR131A, THR133B, THR161A, THR162A, THR163A, THR167B, THR173B, THR192B, THR208A, THR212A, THR92A, TRP103B, TRP35A, TRP36B, TRP47B, TRP64B, TYR100B, TYR147B, TYR173A, TYR178A, TYR36A, TYR58B, TYR86A, VAL102B, VAL115A, VAL121B, VAL133A, VAL144B, VAL159A, VAL171B, VAL177B, VAL190B, VAL191B, VAL209A, VAL225B, VAL33A, VAL37B, VAL46A, VAL48A, VAL48B, VAL51A
• A-C: ALA112A, ALA112C, ALA210A, ALA210C, CYS194A, CYS194C, GLN195A, GLN195C, GLU199A, GLU199C, GLU206A, GLU206C, GLY200A, GLY200C, LEU117A, LEU117C, LYS149A, LYS149C, LYS207A, LYS207C, PRO113A, PRO113C, PRO119C, SER114A, SER114C, SER152A, SER152C, SER191A, SER191C, SER193A, SER193C, SER203A, SER203C, THR197A, THR197C, THR204A, THR204C, THR208A, THR208C, THR212A, THR212C, TYR192C, VAL115A, VAL115C, VAL196A, VAL196C, VAL205A, VAL205C, VAL209A, VAL209C
• A-D: ALA111A, ALA112A, ALA138D, ASN170A, ASP138A, GLN108A, GLN167A, GLN17A, GLU199A, GLY135D, GLY136D, GLY199D, HIS198A, LEU198D, LYS110A, LYS129D, LYS172A, PHE139A, PRO109A, PRO113A, PRO126D, PRO141A, PRO194D, PRO227D, SER114A, SER127D, SER128D, SER130D, SER134D, SER137A, SER195D, SER196D, SER197D, SER203A, SER232D, THR133D, THR137D, THR204A, TYR140A, VAL205A
• A-E: LYS187A, SER56E
• A-F: ALA150A, ALA210A, ARG94F, ASP100F, ASP151A, GLN185A, GLN3F, GLU184A, GLU2F, GLY100F, GLY26F, GLY97F, GLY98F, HIS189A, HIS30F, LYS100F, LYS149A, LYS187A, LYS190A, LYS31F, PHE27F, PHE29F, PRO154A, PRO99F, SER152A, SER153A, SER188A, SER191A, SER193A, SER25F, THR208A, THR212A, THR28F, TRP100F, TYR100F, TYR192A, TYR32F, VAL102F, VAL155A, VAL209A
• A-I: ALA127A, ALA127I, ASN128A, ASN128I, LYS129A, LYS129I
• A-J: ALA114J, ALA127A, ASN128A, ASN216J, ASP146J, GLN126A, GLU123A, GLU124A, GLY118J, GLY183J, HIS212J, LEU125A, LEU184J, LYS117J, LYS129A, PHE148J, PRO119J, SER112J, SER113J, SER115J, SER120J, SER122A, SER182J, SER215J, THR116J, THR217J, TYR147J
• B-C: ALA111C, ALA112C, ALA138B, ASN170C, ASP138C, GLN108C, GLN167C, GLU199C, GLY135B, GLY136B, GLY199B, GLY200C, HIS198C, LEU198B, LYS110C, LYS129B, LYS172C, PHE139C, PRO109C, PRO113C, PRO141C, PRO194B, PRO227B, SER114C, SER127B, SER128B, SER130B, SER134B, SER137C, SER195B, SER196B, SER197B, SER203C, SER232B, THR133B, THR137B, THR204C, TYR140C, TYR173C, VAL205C
• B-D: SER134B, SER134D
• B-I: ALA114B, ALA127I, ASN128I, ASN216B, ASP146B, GLN126I, GLU123I, GLU124I, GLY118B, GLY183B, HIS212B, LEU125I, LEU184B, LYS117B, LYS129I, PHE148B, PRO119B, SER112B, SER113B, SER115B, SER120B, SER122I, SER182B, SER215B, THR116B, THR217B, TYR147B
• B-J: ARG222B, ARG222J, ASN209B, ASN209J, ASN211J, ASN216B, ASN216J, ASP220B, ASP220J, CYS208B, CYS208J, GLU226B, GLU226J, GLY118B, GLY118J, HIS212B, HIS212J, ILE207B, ILE207J, LYS117B, LYS117J, LYS213B, LYS213J, LYS218B, LYS218J, LYS221B, LYS221J, PHE122B, PHE122J, PRO119B, PRO119J, PRO123B, PRO123J, PRO214B, PRO214J, SER120B, SER120J, SER215B, SER215J, THR116B, THR116J, THR205B, THR205J, THR217B, THR217J, TYR206B, TYR206J, VAL121B, VAL121J, VAL210B, VAL210J, VAL219B, VAL219J, VAL225B, VAL225J
• C-D: ALA125D, ALA127C, ALA130C, ALA138D, ALA139D, ALA174C, ALA175C, ALA176D, ALA3C, ALA40D, ALA43C, ALA49D, ALA93D, ALA96D, ARG222D, ARG38D, ARG54C, ARG94C, ARG94D, ARG96C, ASN100D, ASN170C, ASP101D, ASP138C, ASP146D, ASP31C, ASP50C, ASP61D, ASP85C, CYS134C, CYS142D, CYS88C, CYS92D, GLN126C, GLN167C, GLN179D, GLN37C, GLN38C, GLN39D, GLU123C, GLU124C, GLU160C, GLU226D, GLU46D, GLU6D, GLU95D, GLY100C, GLY101C, GLY104D, GLY106D, GLY141D, GLY158C, GLY169D, GLY33D, GLY41C, GLY42D, GLY44D, GLY99C, HIS100D, HIS172D, HIS35D, HIS53C, HIS59D, HIS95C, ILE136C, ILE58C, ILE97C, LEU117C, LEU124D, LEU125C, LEU132C, LEU135C, LEU140D, LEU143D, LEU178D, LEU179C, LEU181C, LEU187D, LEU45D, LEU4D, LEU50D, LEU91C, LYS105D, LYS117D, LYS129C, LYS129D, LYS145D, LYS166C, LYS172C, LYS207C, LYS221D, LYS228D, LYS42C, LYS43D, LYS45C, LYS57D, MET100D, MET47C, MET63D, MET89D, PHE118C, PHE122D, PHE139C, PHE174D, PHE30C, PHE49C, PHE87C, PHE91D, PHE98C, PRO119C, PRO120C, PRO123D, PRO126D, PRO164C, PRO175D, PRO41D, PRO44C, PRO55C, SER114C, SER120D, SER121C, SER122C, SER127D, SER128D, SER130D, SER134D, SER137C, SER165C, SER168C, SER168D, SER176C, SER177C, SER180C, SER180D, SER182D, SER186D, SER188D, SER189D, SER232D, SER2C, SER32C, SER34C, SER56C, SER60D, SER62D, SER89C, SER90C, SER95C, THR116C, THR131C, THR133D, THR161C, THR162C, THR163C, THR167D, THR173D, THR192D, THR208C, THR212C, THR92C, TRP103D, TRP35C, TRP36D, TRP47D, TRP64D, TYR100D, TYR173C, TYR178C, TYR36C, TYR58D, TYR86C, VAL102D, VAL115C, VAL121D, VAL133C, VAL144D, VAL159C, VAL171D, VAL177D, VAL190D, VAL191D, VAL209C, VAL225D, VAL33C, VAL37D, VAL46C, VAL48C, VAL48D, VAL51C
• C-E: ASN24C, ASN69C, ASP31E, GLY25C, GLY68C, HIS53E, LYS66E, PHE30E, SER27C, SER52E, SER67C, THR26C, THR70C, VAL51E
• C-F: ALA143C, ALA147C, ALA3C, ALA8C, ASN100F, ASN24C, ASP100F, GLN195C, GLN6C, GLU199C, GLY100C, GLY101C, GLY200C, GLY99C, HIS100F, HIS198C, LEU4C, LYS100F, LYS103C, LYS149C, LYS156C, PHE100F, PRO154C, PRO7C, SER152C, SER153C, SER203C, SER2C, SER9C, THR102C, THR145C, THR197C, THR204C, THR5C, TRP100F, TYR100F, VAL100F, VAL11C, VAL144C, VAL146C
• E-F: ALA125F, ALA127E, ALA130E, ALA138F, ALA139F, ALA174E, ALA175E, ALA176F, ALA210E, ALA3E, ALA43E, ALA49F, ALA93F, ALA96F, ARG222F, ARG38F, ARG54E, ARG56F, ARG94E, ARG94F, ARG96E, ASN100F, ASN128E, ASN170E, ASP101F, ASP138E, ASP146F, ASP31E, ASP50E, ASP61F, ASP85E, CYS134E, CYS142F, CYS88E, CYS92F, GLN126E, GLN167E, GLN179F, GLN37E, GLN38E, GLN39F, GLN6E, GLU123E, GLU124E, GLU160E, GLU226F, GLU46F, GLU6F, GLU85F, GLU95F, GLY100E, GLY101E, GLY104F, GLY106F, GLY141F, GLY158E, GLY183F, GLY33F, GLY41E, GLY42F, GLY44F, GLY99E, HIS100F, HIS172F, HIS35F, HIS53E, HIS59F, HIS95E, ILE136E, ILE58E, ILE97E, LEU117E, LEU124F, LEU125E, LEU132E, LEU135E, LEU140F, LEU143F, LEU178F, LEU179E, LEU181E, LEU184F, LEU187F, LEU45F, LEU50F, LEU91E, LYS103E, LYS105F, LYS129E, LYS129F, LYS145F, LYS166E, LYS207E, LYS221F, LYS228F, LYS42E, LYS43F, LYS45E, LYS57F, MET100F, MET47E, MET63F, MET89F, PHE118E, PHE122F, PHE139E, PHE174F, PHE30E, PHE49E, PHE87E, PHE91F, PHE98E, PRO119E, PRO119F, PRO120E, PRO123F, PRO126F, PRO164E, PRO175F, PRO40E, PRO41F, PRO44E, PRO55E, SER114E, SER120F, SER121E, SER122E, SER127F, SER128F, SER130F, SER137E, SER165E, SER168E, SER176E, SER177E, SER180E, SER180F, SER182F, SER186F, SER188F, SER189F, SER32E, SER34E, SER39E, SER56E, SER60F, SER62F, SER89E, SER90E, SER95E, THR116E, THR131E, THR133F, THR161E, THR162E, THR163E, THR173F, THR192F, THR208E, THR92E, TRP103F, TRP35E, TRP36F, TRP47F, TRP64F, TYR100F, TYR147F, TYR173E, TYR178E, TYR185F, TYR36E, TYR58F, TYR86E, VAL102F, VAL115E, VAL121F, VAL133E, VAL144E, VAL144F, VAL146E, VAL159E, VAL177F, VAL190F, VAL191F, VAL209E, VAL225F, VAL33E, VAL37F, VAL46E, VAL48E, VAL48F, VAL51E
• E-J: ARG61E, ARG66J, ASN60E, ASP61J, ASP82E, ASP86J, GLN108E, GLN17E, GLN81J, GLU81E, GLU83E, GLY107E, GLY13E, GLY15J, GLY16E, GLY16J, GLY57E, GLY65J, GLY77E, HIS59J, HIS79E, ILE58E, ILE69J, ILE75E, ILE80E, LEU106E, LEU18J, LEU78E, LEU82J, LYS57J, LYS83J, MET63J, PHE62E, PHE82J, PRO15E, SER14E, SER17J, SER59E, SER62J, SER70J, SER76E, SER82J, THR105E, THR68J, TRP64J, TYR140E, VAL106E, VAL67J
• G-H: ALA125H, ALA127G, ALA130G, ALA138H, ALA139H, ALA174G, ALA175G, ALA176H, ALA210G, ALA3G, ALA43G, ALA49H, ALA93H, ALA96H, ARG222H, ARG38H, ARG54G, ARG56H, ARG94G, ARG94H, ARG96G, ASN100H, ASN128G, ASN170G, ASP101H, ASP138G, ASP146H, ASP31G, ASP50G, ASP61H, ASP85G, CYS134G, CYS142H, CYS88G, CYS92H, GLN126G, GLN167G, GLN179H, GLN37G, GLN38G, GLN39H, GLN6G, GLU123G, GLU124G, GLU160G, GLU46H, GLU6H, GLU95H, GLY100G, GLY101G, GLY104H, GLY106H, GLY141H, GLY158G, GLY169H, GLY33H, GLY41G, GLY42H, GLY44H, GLY99G, HIS100H, HIS172H, HIS35H, HIS53G, HIS59H, HIS95G, ILE136G, ILE58G, ILE97G, LEU117G, LEU124H, LEU125G, LEU132G, LEU135G, LEU140H, LEU143H, LEU178H, LEU179G, LEU181G, LEU187H, LEU45H, LEU4G, LEU4H, LEU50H, LEU91G, LYS105H, LYS117H, LYS129G, LYS129H, LYS145H, LYS166G, LYS172G, LYS207G, LYS221H, LYS228H, LYS42G, LYS43H, LYS45G, LYS57H, MET100H, MET47G, MET63H, MET89H, PHE118G, PHE122H, PHE139G, PHE174H, PHE30G, PHE49G, PHE87G, PHE91H, PHE98G, PRO119G, PRO120G, PRO123H, PRO126H, PRO164G, PRO175H, PRO41H, PRO44G, PRO55G, SER114G, SER120H, SER121G, SER122G, SER127H, SER128H, SER130H, SER134H, SER137G, SER165G, SER168G, SER168H, SER176G, SER177G, SER180G, SER180H, SER181H, SER186H, SER188H, SER189H, SER232H, SER2G, SER32G, SER34G, SER56G, SER60H, SER62H, SER89G, SER90G, SER95G, THR116G, THR131G, THR133H, THR161G, THR162G, THR163G, THR167H, THR173H, THR192H, THR208G, THR212G, THR92G, TRP103H, TRP186G, TRP35G, TRP36H, TRP47H, TRP64H, TYR100H, TYR147H, TYR173G, TYR178G, TYR36G, TYR58H, TYR86G, VAL102H, VAL115G, VAL121H, VAL133G, VAL144H, VAL159G, VAL170H, VAL177H, VAL190H, VAL191H, VAL209G, VAL225H, VAL33G, VAL37H, VAL46G, VAL48G, VAL48H, VAL51G
• G-I: ALA112G, ALA112I, ALA210G, ALA210I, CYS194G, CYS194I, GLN195G, GLN195I, GLU199G, GLU199I, GLU206G, GLU206I, GLY200G, GLY200I, LEU117G, LEU117I, LYS149G, LYS149I, LYS207G, LYS207I, PRO113G, PRO113I, PRO119G, PRO119I, SER114G, SER114I, SER152G, SER152I, SER191G, SER191I, SER193G, SER193I, SER203G, SER203I, THR197G, THR197I, THR204G, THR204I, THR208G, THR208I, THR212G, THR212I, TYR192G, VAL115G, VAL115I, VAL196G, VAL196I, VAL205G, VAL205I, VAL209G, VAL209I
• G-J: ALA111G, ALA112G, ALA138J, ASN170G, ASP138G, GLN108G, GLN167G, GLN17G, GLU199G, GLY135J, GLY136J, GLY199J, HIS198G, LEU198J, LYS110G, LYS129J, LYS172G, PHE139G, PRO109G, PRO113G, PRO141G, PRO194J, PRO227J, SER114G, SER127J, SER128J, SER130J, SER134J, SER137G, SER195J, SER196J, SER197J, SER203G, SER232J, THR133J, THR137J, THR204G, TYR140G, VAL205G
• G-K: LYS187G, SER56K
• G-L: ALA150G, ALA210G, ARG94L, ASP151G, GLN185G, GLN3L, GLU184G, GLU2L, GLY26L, GLY97L, GLY98L, HIS189G, HIS30L, LYS100L, LYS149G, LYS187G, LYS190G, LYS31L, PHE27L, PHE29L, PRO154G, PRO99L, SER152G, SER153G, SER188G, SER191G, SER25L, THR208G, THR28L, TRP100L, TYR100L, TYR192G, TYR32L, VAL155G
• H-I: ALA111I, ALA112I, ALA138H, ASN170I, ASP138I, GLN108I, GLN167I, GLN17I, GLU199I, GLY135H, GLY136H, GLY199H, GLY200I, HIS198I, LEU198H, LYS110I, LYS129H, LYS172I, LYS228H, PHE139I, PRO109I, PRO113I, PRO141I, PRO194H, PRO227H, SER114I, SER127H, SER128H, SER130H, SER134H, SER137I, SER195H, SER196H, SER197H, SER203I, SER232H, THR133H, THR137H, THR204I, TYR140I, VAL205I
• H-J: SER134H, SER134J
• I-J: ALA125J, ALA127I, ALA130I, ALA138J, ALA139J, ALA174I, ALA175I, ALA176J, ALA3I, ALA40J, ALA43I, ALA49J, ALA93J, ALA96J, ARG222J, ARG38J, ARG54I, ARG94I, ARG94J, ARG96I, ASN100J, ASN170I, ASP101J, ASP138I, ASP146J, ASP31I, ASP50I, ASP61J, ASP85I, CYS134I, CYS142J, CYS88I, CYS92J, GLN126I, GLN167I, GLN179J, GLN37I, GLN38I, GLN39J, GLU123I, GLU124I, GLU160I, GLU226J, GLU46J, GLU6J, GLU95J, GLY100I, GLY101I, GLY104J, GLY106J, GLY141J, GLY158I, GLY169J, GLY33J, GLY41I, GLY42J, GLY44J, GLY99I, HIS100J, HIS172J, HIS35J, HIS53I, HIS59J, HIS95I, ILE136I, ILE58I, ILE97I, LEU117I, LEU124J, LEU125I, LEU132I, LEU135I, LEU140J, LEU143J, LEU178J, LEU179I, LEU181I, LEU184J, LEU187J, LEU45J, LEU4J, LEU50J, LEU91I, LYS105J, LYS117J, LYS129I, LYS129J, LYS145J, LYS156I, LYS166I, LYS172I, LYS207I, LYS221J, LYS228J, LYS42I, LYS43J, LYS45I, MET100J, MET47I, MET63J, MET89J, PHE118I, PHE122J, PHE139I, PHE174J, PHE30I, PHE49I, PHE87I, PHE91J, PHE98I, PRO119I, PRO120I, PRO123J, PRO126J, PRO164I, PRO175J, PRO41J, PRO44I, PRO55I, SER114I, SER120J, SER121I, SER122I, SER127J, SER128J, SER130J, SER134J, SER137I, SER165I, SER168I, SER168J, SER176I, SER177I, SER180I, SER180J, SER182J, SER186J, SER188J, SER189J, SER232J, SER2I, SER32I, SER34I, SER56I, SER60J, SER62J, SER89I, SER90I, SER95I, THR116I, THR131I, THR133J, THR161I, THR162I, THR163I, THR167J, THR173J, THR192J, THR208I, THR212I, THR92I, TRP103J, TRP35I, TRP36J, TRP47J, TRP64J, TYR100J, TYR173I, TYR178I, TYR36I, TYR58J, TYR86I, VAL102J, VAL115I, VAL121J, VAL133I, VAL144J, VAL159I, VAL171J, VAL177J, VAL190J, VAL191J, VAL209I, VAL225J, VAL33I, VAL37J, VAL46I, VAL48I, VAL48J, VAL51I
• I-K: ARG54K, ASN24I, ASN69I, ASP27I, ASP31K, ASP50K, CYS23I, GLY25I, GLY28I, GLY28K, GLY29I, GLY29K, GLY64K, GLY68I, GLY68K, HIS53K, LYS66I, LYS66K, PHE30K, PHE49K, SER22I, SER27I, SER32K, SER52K, SER63K, SER65K, SER67I, SER67K, THR26I, THR5I, THR70I, VAL27I, VAL27K, VAL33K, VAL51K
• I-L: ALA143I, ALA147I, ALA150I, ALA3I, ALA8I, ASN100L, ASN24I, ASP100L, ASP151I, CYS23I, GLN195I, GLN6I, GLU199I, GLY100I, GLY100L, GLY101I, GLY200I, GLY25I, GLY99I, HIS100L, ILE100L, LEU4I, LYS100L, LYS149I, LYS156I, PHE100L, PHE98I, PRO154I, PRO7I, SER152I, SER153I, SER2I, SER9I, THR102I, THR145I, THR197I, THR204I, THR5I, TRP100L, TYR100L, VAL100L, VAL11I, VAL144I, VAL146I
• J-L: ASP100L, GLY44J, HIS100L, LYS43J, TYR100L, VAL100L
• K-L: ALA125L, ALA127K, ALA130K, ALA138L, ALA139L, ALA174K, ALA175K, ALA176L, ALA210K, ALA3K, ALA40L, ALA43K, ALA49L, ALA93L, ALA96L, ARG222L, ARG38L, ARG54K, ARG56L, ARG94K, ARG94L, ARG96K, ASN100L, ASN128K, ASN170K, ASP101L, ASP138K, ASP146L, ASP31K, ASP50K, ASP61L, ASP85K, CYS134K, CYS142L, CYS88K, CYS92L, GLN126K, GLN167K, GLN179L, GLN37K, GLN38K, GLN39L, GLN6K, GLU123K, GLU124K, GLU160K, GLU213K, GLU226L, GLU46L, GLU6L, GLU85L, GLU95L, GLY100K, GLY101K, GLY104L, GLY106L, GLY141L, GLY158K, GLY183L, GLY33L, GLY41K, GLY42L, GLY44L, GLY99K, HIS100L, HIS172L, HIS35L, HIS53K, HIS59L, HIS95K, ILE100L, ILE136K, ILE58K, ILE97K, LEU117K, LEU124L, LEU125K, LEU132K, LEU135K, LEU140L, LEU143L, LEU178L, LEU179K, LEU181K, LEU184L, LEU187L, LEU45L, LEU4L, LEU50L, LEU91K, LYS105L, LYS129K, LYS129L, LYS145L, LYS166K, LYS207K, LYS221L, LYS228L, LYS42K, LYS43L, LYS45K, LYS57L, MET100L, MET47K, MET63L, MET89L, PHE118K, PHE122L, PHE139K, PHE174L, PHE30K, PHE49K, PHE87K, PHE91L, PHE98K, PRO119K, PRO120K, PRO123L, PRO126L, PRO164K, PRO175L, PRO211K, PRO41L, PRO44K, PRO55K, SER114K, SER120L, SER121K, SER122K, SER127L, SER128L, SER130L, SER137K, SER165K, SER168K, SER176K, SER177K, SER180K, SER180L, SER182L, SER186L, SER188L, SER189L, SER32K, SER34K, SER56K, SER60L, SER62L, SER89K, SER90K, SER95K, THR102K, THR116K, THR131K, THR133L, THR161K, THR162K, THR163K, THR173L, THR192L, THR212K, THR92K, TRP103L, TRP186K, TRP35K, TRP36L, TRP47L, TRP64L, TYR100L, TYR147L, TYR173K, TYR178K, TYR185L, TYR36K, TYR58L, TYR86K, VAL102L, VAL115K, VAL121L, VAL133K, VAL144K, VAL144L, VAL146K, VAL159K, VAL177L, VAL190L, VAL191L, VAL209K, VAL225L, VAL33K, VAL37L, VAL46K, VAL48K, VAL48L, VAL51K, VAL84L