3MT6

structure of clpp from escherichia coli in complex with adep1

• Total interactions analyzed: 1540
• Total true interactions: 158
• Strongest Interaction:
  • Chains: O-A
  • Int. Res.: 6
  • Norm. En. per Res.: -5.6138
• Hub Node: R(10)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
R-S	-28.0153	-64.2812	-347.645	-439.9415	134	17	14	14606	4	33	31
R-T	0.0	0.0	-0.0546	-0.0546	2	0	0	21	0	0	0
R-Q	-40.2114	-63.93	-314.845	-418.9864	126	13	12	12957	4	31	27
R-Y	-110.2451	-6.55	-224.267	-341.0621	69	10	9	8534	0	20	16
R-Z	0.0	0.0	-0.6815	-0.6815	10	0	0	62	0	0	1
R-X	-11.2547	-13.2132	-22.4971	-46.965	16	0	0	824	2	8	11
R-H	-4.859	-0.7054	-23.0175	-28.5819	16	1	0	960	0	10	12
R-B	-8.4219	0.0	-6.9479	-15.3698	7	0	0	228	4	4	7
R-r	-3.9542	0.0	-63.8753	-67.8295	29	4	6	3172	0	0	0
R-s	0.0	0.0	-46.4103	-46.4103	20	3	1	2404	0	0	0
S-T	-31.4413	-63.3507	-343.302	-438.094	139	21	11	14334	4	36	34
S-U	0.0	0.0	-0.0079	-0.0079	2	0	0	8	0	0	0
S-Q	0.0	0.0	-0.0012	-0.0012	3	0	0	3	0	0	0
S-Y	-9.6875	-31.4063	-21.4382	-62.5321	14	0	0	763	1	7	10
S-Z	-109.4668	-7.0801	-222.365	-338.912	69	14	9	8495	0	18	16
S-a	0.0	0.0	-0.68	-0.68	10	0	0	61	0	0	1
S-H	0.0	0.0	-0.7189	-0.7189	9	0	0	78	0	3	5
S-s	0.0	0.0	-62.6899	-62.6899	27	5	6	3160	0	0	0
S-t	0.0	0.0	-48.1158	-48.1158	21	2	1	2349	0	0	0
T-U	-31.4305	-81.9618	-336.179	-449.5713	137	8	11	14497	5	35	35
T-O	0.0	0.0	-0.0289	-0.0289	2	0	0	12	0	0	0
T-Z	-10.1863	-11.8664	-22.336	-44.3886	14	0	0	786	2	8	10
T-a	-106.6883	-1.6014	-224.146	-332.4357	68	15	9	8589	0	20	16
T-b	0.0	0.0	-0.6818	-0.6818	10	0	0	59	0	0	1
T-t	0.0	0.0	-56.9133	-56.9133	27	4	6	3087	0	0	0
T-u	0.0	0.0	-48.9953	-48.9953	20	1	1	2388	0	0	0
U-O	-35.9906	-55.9374	-324.756	-416.6841	134	16	11	13845	4	33	32
U-P	0.0	0.0	-0.014	-0.014	2	0	0	11	0	0	0
U-a	-10.604	-11.6019	-22.7805	-44.9863	14	0	0	785	2	6	9
U-b	-97.707	-4.9418	-221.172	-323.8209	67	9	9	8392	0	19	16
U-V	0.0	0.0	-0.7037	-0.7037	10	0	0	58	0	0	1
U-o	0.0	0.0	-49.8827	-49.8827	20	1	2	2397	0	0	0
U-u	0.0	0.0	-58.7666	-58.7666	26	3	6	3045	0	0	0
O-P	-34.8288	-109.7633	-340.061	-484.653	142	23	12	14852	6	37	35
O-b	-10.5326	-10.3052	-22.5366	-43.3744	14	0	0	777	2	6	11
O-V	-112.9862	-2.8786	-222.449	-338.3138	67	16	9	8544	0	22	15
O-W	0.0	0.0	-0.709	-0.709	10	0	0	57	0	0	1
O-A	-2.4554	-25.591	-5.6365	-33.683	6	0	0	198	2	2	1
O-o	0.0	0.0	-61.4584	-61.4584	26	3	6	3093	0	0	0
O-p	0.0	0.0	-48.8219	-48.8219	20	1	1	2466	0	0	0
P-Q	-51.3715	-116.2452	-363.21	-530.8267	142	13	10	14139	7	38	34
P-V	-9.3511	-32.3894	-20.9311	-62.6715	14	0	0	754	2	7	11
P-W	-121.9866	-6.8714	-226.83	-355.6881	66	13	9	8523	0	20	15
P-X	0.0	0.0	-0.704	-0.704	10	0	0	55	0	0	1
P-A	-14.2833	-3.1768	-23.7119	-41.1719	19	1	0	1101	0	5	6
P-p	0.0	0.0	-57.0619	-57.0619	27	4	6	3182	0	0	0
P-q	0.0	0.0	-45.6717	-45.6717	20	2	1	2352	0	0	0
Q-Y	0.0	0.0	-0.7126	-0.7126	10	0	0	62	0	0	1
Q-W	-9.807	-13.1277	-22.6846	-45.6192	15	0	0	780	2	8	11
Q-X	-105.5761	-2.9261	-218.566	-327.0682	68	10	9	8414	0	22	15
Q-B	-3.7846	-15.1249	-59.0215	-77.931	41	1	0	2485	3	16	18
Q-A	0.0	5.8335	-3.6404	2.1932	9	0	0	253	0	4	6
Q-q	-11.2552	0.0	-59.7007	-70.9559	27	6	6	3071	0	0	0
Q-r	0.0	0.0	-47.1463	-47.1463	21	0	2	2445	0	0	0
Y-Z	-42.8386	-61.7523	-355.007	-459.5979	138	17	12	14484	4	32	30
Y-a	0.0	0.0	-0.0148	-0.0148	2	0	0	10	0	0	0
Y-W	0.0	0.0	-0.0133	-0.0133	2	0	0	10	0	0	0
Y-X	-37.4328	-94.7401	-352.581	-484.7539	141	18	12	14998	6	39	34
Y-x	0.0	0.0	-56.3445	-56.3445	21	2	1	2588	0	0	0
Y-y	0.0	0.0	-62.8812	-62.8812	28	4	6	3225	0	0	0
Z-a	-43.8256	-63.7138	-364.221	-471.7604	133	15	12	14760	4	31	30
Z-b	0.0	0.0	-0.0103	-0.0103	2	0	0	9	0	0	0
Z-X	0.0	0.0	-0.032	-0.032	2	0	0	13	0	0	0
Z-y	0.0	0.0	-45.5668	-45.5668	20	0	1	2362	0	0	0
Z-z	-5.7841	0.0	-58.1426	-63.9267	28	7	6	3192	0	0	0
a-b	-42.9329	-55.7107	-305.12	-403.7636	132	12	11	13365	4	32	27
a-z	0.0	0.0	-46.9393	-46.9393	20	1	1	2367	0	0	0
a-3	-10.889	0.0	-64.6423	-75.5313	30	6	6	3513	0	0	0
b-V	-43.6167	-60.2074	-331.554	-435.3782	130	9	11	13627	4	30	27
b-W	0.0	0.0	-0.0005	-0.0005	2	0	0	2	0	0	0
b-3	0.0	0.0	-51.8827	-51.8827	19	1	2	2457	0	0	0
b-4	-9.885	0.0	-58.1593	-68.0443	27	6	6	3093	0	0	0
V-W	-45.4855	-58.845	-334.402	-438.7325	128	13	8	13596	4	32	30
V-v	-6.1858	0.0	-54.6952	-60.881	25	6	6	3087	0	0	0
V-4	0.0	0.0	-43.63	-43.63	20	0	1	2329	0	0	0
W-X	-45.4012	-67.6426	-366.272	-479.3158	143	8	11	14927	4	34	31
W-v	0.0	0.0	-45.9184	-45.9184	21	0	1	2354	0	0	0
W-w	0.0	0.0	-63.8028	-63.8028	28	4	6	3237	0	0	0
X-w	0.0	0.0	-44.7229	-44.7229	19	0	1	2289	0	0	0
X-x	0.0	0.0	-61.5525	-61.5525	27	7	6	3239	0	0	0
M-L	-32.0694	-89.4496	-359.049	-480.568	143	11	11	14997	6	39	34
M-K	0.0	0.0	-0.0619	-0.0619	2	0	0	25	0	0	0
M-H	0.0	0.0	-0.0389	-0.0389	2	0	0	17	0	0	0
M-N	-42.4797	-71.2065	-323.224	-436.9102	142	13	10	14053	4	34	31
M-F	-105.462	-4.6639	-227.336	-337.462	66	9	9	8584	0	19	16
M-E	0.0	0.0	-0.6653	-0.6653	10	0	0	56	0	0	1
M-G	-10.0906	-12.6316	-22.32	-45.0421	14	0	0	774	2	7	11
M-l	0.0	0.0	-47.2377	-47.2377	20	0	1	2392	0	0	0
M-m	0.0	0.0	-56.035	-56.035	26	3	6	3102	0	0	0
L-K	-29.5959	-58.6587	-350.423	-438.6776	138	14	11	14537	4	36	35
L-J	0.0	0.0	-0.0117	-0.0117	2	0	0	10	0	0	0
L-N	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
L-F	-10.1061	-32.8206	-22.6447	-65.5714	14	0	0	778	2	7	10
L-E	-116.9074	-1.8839	-218.957	-337.7483	68	12	9	8440	0	21	17
L-D	0.0	0.0	-0.6742	-0.6742	10	0	0	58	0	0	1
L-k	0.0	0.0	-46.7493	-46.7493	20	0	1	2380	0	0	0
L-l	0.0	0.0	-59.2563	-59.2563	26	3	6	3061	0	0	0
K-J	-28.7037	-62.9678	-342.019	-433.6905	141	13	10	14448	4	36	33
K-E	-9.9059	-11.9009	-22.7457	-44.5526	14	0	0	786	2	6	10
K-D	-107.9036	-2.9184	-220.523	-331.345	68	9	9	8389	0	21	15
K-C	0.0	0.0	-0.7392	-0.7392	8	0	0	67	0	0	1
K-j	0.0	0.0	-46.8554	-46.8554	20	0	1	2367	0	0	0
K-k	-7.1815	0.0	-59.1878	-66.3693	25	4	6	3088	0	0	0
J-I	-59.1312	-119.3439	-358.255	-536.7301	142	19	10	14888	7	37	34
J-H	0.0	0.0	-0.0011	-0.0011	2	0	0	3	0	0	0
J-D	-10.7608	-9.3996	-22.66	-42.8205	14	0	0	787	2	7	10
J-C	-93.9665	-14.6702	-221.659	-330.2957	65	9	9	8460	0	20	16
J-B	0.0	0.0	-0.6691	-0.6691	10	0	0	58	0	0	1
J-i	0.0	0.0	-45.4986	-45.4986	21	2	1	2319	0	0	0
J-j	-13.9441	0.0	-56.0065	-69.9506	28	6	6	3144	0	0	0
I-H	-34.1222	-98.6352	-361.381	-494.1384	140	11	10	14552	6	37	35
I-N	0.0	0.0	-0.047	-0.047	2	0	0	19	0	0	0
I-C	-10.85	-11.3815	-22.7151	-44.9466	14	0	0	783	2	7	11
I-B	-108.7031	-6.6441	-220.562	-335.9093	67	12	9	8524	0	20	15
I-A	0.0	0.0	-0.6768	-0.6768	10	0	0	61	0	0	1
I-h	0.0	0.0	-45.6773	-45.6773	20	2	1	2302	0	0	0
I-i	-10.3259	0.0	-61.2834	-71.6093	28	5	6	3118	0	0	0
H-N	-28.6389	-57.9922	-348.108	-434.7391	142	15	11	14473	4	36	34
H-B	-10.1782	-32.3067	-21.8865	-64.3714	14	0	0	768	2	8	11
H-A	-94.9588	-8.0347	-228.526	-331.5195	66	11	9	8554	0	19	16
H-G	0.0	0.0	-0.6782	-0.6782	10	0	0	60	0	0	1
H-h	0.0	0.0	-57.8833	-57.8833	28	6	6	3151	0	0	0
H-n	0.0	0.0	-45.8906	-45.8906	20	0	1	2356	0	0	0
H-s	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
N-F	0.0	0.0	-0.7163	-0.7163	10	0	0	60	0	0	1
N-A	-9.8041	-31.8455	-21.7175	-63.3671	14	0	0	759	2	6	11
N-G	-115.8583	-7.0266	-222.786	-345.6709	67	13	9	8542	0	19	17
N-m	0.0	0.0	-45.9189	-45.9189	21	1	1	2380	0	0	0
N-n	0.0	0.0	-56.2742	-56.2742	27	4	6	3143	0	0	0
F-E	-49.6609	-92.8991	-368.567	-511.127	140	11	11	14891	6	35	33
F-D	0.0	0.0	-0.0041	-0.0041	2	0	0	5	0	0	0
F-A	0.0	0.0	-0.0079	-0.0079	2	0	0	8	0	0	0
F-G	-42.7829	-92.9994	-379.769	-515.5513	146	17	11	15312	5	39	36
F-f	0.0	0.0	-59.897	-59.897	28	7	6	3125	0	0	0
F-g	0.0	0.0	-47.7355	-47.7355	20	0	1	2404	0	0	0
E-D	-53.4351	-79.6815	-338.303	-471.4196	141	21	11	14491	5	34	33
E-C	0.0	0.0	-0.0009	-0.0009	2	0	0	3	0	0	0
E-G	0.0	0.0	-0.0167	-0.0167	3	0	0	12	0	0	0
E-e	0.0	0.0	-54.3706	-54.3706	28	5	6	3269	0	0	0
E-f	0.0	0.0	-47.0075	-47.0075	20	2	2	2383	0	0	0
D-C	-48.8424	-76.7238	-363.893	-489.4592	141	21	11	14990	5	36	33
D-B	0.0	0.0	-0.0035	-0.0035	2	0	0	5	0	0	0
D-d	0.0	0.0	-56.9401	-56.9401	27	4	6	3134	0	0	0
D-e	0.0	0.0	-45.5065	-45.5065	21	1	1	2331	0	0	0
C-B	-50.5614	-87.0542	-359.885	-497.5006	141	16	11	14580	6	35	33
C-A	0.0	0.0	-0.0046	-0.0046	2	0	0	8	0	0	0
C-c	0.0	0.0	-58.7561	-58.7561	26	3	6	3069	0	0	0
C-d	0.0	0.0	-46.5519	-46.5519	20	1	1	2335	0	0	0
B-A	-56.7137	-103.0318	-365.658	-525.4035	145	21	10	15079	6	38	36
B-G	0.0	0.0	-0.0142	-0.0142	2	0	0	11	0	0	0
B-2	0.0	0.0	-59.3638	-59.3638	27	3	5	3064	0	0	0
B-c	0.0	0.0	-47.4024	-47.4024	21	1	1	2409	0	0	0
B-r	0.0	0.0	-0.4591	-0.4591	6	0	0	106	0	0	0
A-G	-67.1434	-113.8897	-373.534	-554.5671	150	25	11	16537	6	46	39
A-1	-2.0947	0.0	-76.1136	-78.2083	29	10	6	3625	0	0	0
A-2	0.0	0.0	-46.626	-46.626	21	2	1	2374	0	0	0
G-1	0.0	0.0	-46.5148	-46.5148	22	2	2	2388	0	0	0
G-g	-9.4973	0.0	-64.2958	-73.7931	27	7	6	3176	0	0	0

Interface residues

• R-S: ALA132R, ALA139R, ALA176S, ALA40R, ALA45R, ALA52R, ALA72R, ALA95S, ALA96S, ARG118S, ARG140R, ARG148R, ARG15S, ARG170S, ARG172S, ARG22R, ARG22S, ASN116S, ASN41R, ASN64S, ASP134R, ASP171S, ASP18R, ASP18S, ASP37R, ASP78R, CYS113S, CYS91S, GLN131R, GLN34S, GLN46R, GLN81R, GLN94S, GLU136R, GLU141R, GLU151R, GLU169S, GLU178S, GLU26S, GLU36R, GLU51R, GLU53R, GLU8S, GLY130R, GLY33S, GLY67S, GLY73R, GLY93S, HIS122S, HIS138R, HIS156R, HIS191S, HIS38R, ILE121S, ILE135R, ILE137R, ILE142R, ILE188S, ILE19R, ILE19S, ILE29R, ILE29S, ILE43R, ILE63S, ILE70R, ILE76R, ILE7S, ILE83R, ILE90S, LEU114S, LEU152R, LEU155R, LEU174S, LEU189S, LEU23S, LEU24R, LEU2S, LEU31S, LEU42R, LEU48R, LEU50R, LYS144R, LYS146R, LYS25R, LYS84R, MET120S, MET149R, MET39R, MET39S, MET47R, MET5R, MET5S, MET74R, MET80R, MET92S, PHE101R, PHE112S, PHE173S, PHE17R, PHE17S, PHE30R, PHE30S, PHE49R, PHE82R, PRO115S, PRO177S, PRO4S, PRO66S, SER117S, SER16R, SER16S, SER175S, SER21R, SER65S, SER75R, THR133R, THR190S, THR32S, THR71R, THR79R, TYR128R, TYR20R, TYR20S, TYR62S, TYR77R, VAL119S, VAL145R, VAL28R, VAL28S, VAL3R, VAL3S, VAL44R, VAL69R, VAL6S
• R-T: LEU2T, LEU42R
• R-Q: ALA132Q, ALA139Q, ALA176R, ALA40Q, ALA45Q, ALA52Q, ALA72Q, ALA95R, ALA96R, ARG118R, ARG140Q, ARG148Q, ARG15Q, ARG170R, ARG172R, ARG22Q, ARG22R, ASN116R, ASN41Q, ASN64R, ASP134Q, ASP171R, ASP18Q, ASP18R, ASP37Q, ASP78Q, CYS113R, CYS91R, GLN131Q, GLN34R, GLN46Q, GLN81Q, GLN94R, GLU136Q, GLU141Q, GLU169R, GLU178R, GLU26R, GLU36Q, GLU53Q, GLY130Q, GLY33R, GLY73Q, GLY93R, HIS122R, HIS138Q, HIS156Q, HIS191R, HIS38Q, ILE121R, ILE135Q, ILE137Q, ILE142Q, ILE188R, ILE19R, ILE29Q, ILE29R, ILE43Q, ILE63R, ILE70Q, ILE76Q, ILE83Q, ILE90R, LEU114R, LEU143Q, LEU152Q, LEU155Q, LEU174R, LEU189R, LEU23R, LEU24Q, LEU31R, LEU42Q, LEU48Q, LEU50Q, LYS144Q, LYS146Q, LYS25Q, LYS84Q, MET120R, MET149Q, MET39Q, MET39R, MET47Q, MET5Q, MET5R, MET74Q, MET80Q, MET92R, PHE101Q, PHE112R, PHE173R, PHE17Q, PHE17R, PHE30Q, PHE30R, PHE49Q, PHE82Q, PRO115R, PRO177R, PRO4R, PRO66R, SER117R, SER16Q, SER16R, SER175R, SER21Q, SER65R, SER75Q, THR133Q, THR190R, THR32R, THR71Q, THR79Q, TYR128Q, TYR20Q, TYR20R, TYR62R, TYR77Q, VAL119R, VAL145Q, VAL28R, VAL3R, VAL44Q, VAL69Q, VAL6R
• R-Y: ALA132R, ALA132Y, ALA139R, ALA139Y, ARG140R, ARG140Y, ARG170R, ARG170Y, ASN150R, ASN150Y, ASP134R, ASP134Y, ASP171R, ASP171Y, GLN123R, GLN123Y, GLN129R, GLN129Y, GLN131R, GLN131Y, GLU136R, GLU136Y, GLU141R, GLU141Y, GLU165R, GLU169R, GLU169Y, GLY126R, GLY126Y, GLY127R, GLY127Y, GLY130R, GLY130Y, GLY147R, GLY147Y, HIS122R, HIS122Y, HIS138R, HIS138Y, ILE121R, ILE121Y, ILE135R, ILE135Y, ILE137R, ILE137Y, ILE142R, ILE142Y, ILE70R, ILE70Y, LEU125R, LEU125Y, LEU143R, LEU143Y, LYS144R, LYS144Y, LYS146R, LYS146Y, MET120R, MET120Y, PRO124R, PRO124Y, THR133R, THR133Y, THR168R, THR168Y, TYR128R, TYR128Y, VAL145R, VAL145Y
• R-Z: ASP134R, ASP134Z, GLN131R, GLN131Z, HIS138R, HIS138Z, ILE137R, ILE137Z, TYR128R, TYR128Z
• R-X: ARG166R, ARG166X, ARG170R, ARG170X, ASP171R, ASP171X, GLN123R, GLN123X, GLU169R, GLU169X, HIS122R, HIS122X, LYS146R, LYS146X, THR168R, THR168X
• R-H: ALA52R, ARG166H, ARG27R, ASN54R, GLN163H, GLU162H, GLU165H, GLU51R, GLU53R, GLU56R, LEU161H, LEU50R, LYS57R, PHE49R, PRO55R, SER160H
• R-B: ARG166B, ARG22R, ARG27R, GLN163B, GLU26R, LYS25R, LYS57R
• R-r: ALA705-3.9541842.644283, ALA705r, ARG111R, ASP58R, CYS91R, GLU26R, GLY93R, HIS191R, ILE59R, ILE63R, ILE90R, LEU114R, LEU189R, LEU23R, LEU61R, LYS110R, MET92R, PHE112R, PHE30R, PHE701r, PRO115R, PRO703r, SER702r, SER88R, THR190R, THR89R, TYR60R, TYR62R, VAL28R
• R-s: ALA45R, ALA52R, ALA705s, ASP78R, GLN81R, GLU51R, ILE76R, ILE83R, LEU48R, LYS84R, MET47R, MET80R, PHE701s, PHE82R, PRO55R, PRO703s, SER702s, SER75R, THR79R, VAL44R
• S-T: ALA132S, ALA139S, ALA176T, ALA40S, ALA45S, ALA52S, ALA72S, ALA95T, ALA96T, ARG118T, ARG140S, ARG148S, ARG15S, ARG170T, ARG172T, ARG22S, ARG22T, ASN116T, ASN41S, ASN64T, ASP134S, ASP171T, ASP18S, ASP18T, ASP37S, ASP78S, CYS113T, CYS91T, GLN131S, GLN34T, GLN46S, GLN81S, GLN94T, GLN9T, GLU136S, GLU141S, GLU14T, GLU151S, GLU169T, GLU178T, GLU26T, GLU36S, GLU51S, GLU53S, GLU8S, GLU8T, GLY130S, GLY33T, GLY67T, GLY73S, GLY93T, HIS122T, HIS138S, HIS156S, HIS191T, HIS38S, ILE121T, ILE135S, ILE137S, ILE142S, ILE188T, ILE19S, ILE19T, ILE29S, ILE29T, ILE43S, ILE63T, ILE70S, ILE76S, ILE7T, ILE83S, ILE90T, LEU114T, LEU125T, LEU152S, LEU174T, LEU189T, LEU23S, LEU23T, LEU24S, LEU2S, LEU2T, LEU31T, LEU42S, LEU48S, LEU50S, LYS144S, LYS146S, LYS25S, LYS84S, MET120T, MET149S, MET39S, MET39T, MET47S, MET5S, MET5T, MET74S, MET80S, MET92T, PHE101S, PHE112T, PHE173T, PHE17S, PHE17T, PHE30S, PHE30T, PHE49S, PHE82S, PRO115T, PRO177T, PRO4S, PRO4T, PRO66T, SER117T, SER16S, SER16T, SER175T, SER21S, SER65T, SER75S, THR133S, THR190T, THR32T, THR71S, THR79S, TYR128S, TYR20S, TYR20T, TYR62T, TYR77S, VAL119T, VAL145S, VAL28T, VAL3S, VAL3T, VAL44S, VAL69S, VAL6T
• S-U: LEU2U, LEU42S
• S-Q: HIS38Q, LEU2S, LEU42Q
• S-Y: ARG170S, ARG170Y, ASP171S, ASP171Y, GLN123S, GLN123Y, GLU169S, GLU169Y, HIS122S, HIS122Y, LYS146S, LYS146Y, THR168S, THR168Y
• S-Z: ALA132S, ALA132Z, ALA139S, ALA139Z, ARG140S, ARG140Z, ARG170S, ARG170Z, ASN150S, ASN150Z, ASP134S, ASP134Z, ASP171S, ASP171Z, GLN123S, GLN123Z, GLN129S, GLN129Z, GLN131S, GLN131Z, GLU136S, GLU136Z, GLU141S, GLU141Z, GLU165S, GLU165Z, GLU169S, GLU169Z, GLY126S, GLY126Z, GLY127S, GLY127Z, GLY130S, GLY130Z, GLY147S, GLY147Z, HIS122S, HIS122Z, HIS138S, HIS138Z, ILE121S, ILE121Z, ILE135S, ILE135Z, ILE137S, ILE137Z, ILE142S, ILE142Z, ILE70S, ILE70Z, LEU125S, LEU125Z, LEU143S, LEU143Z, LYS144S, LYS144Z, LYS146S, LYS146Z, MET120Z, PRO124S, PRO124Z, THR133S, THR133Z, THR168S, THR168Z, TYR128S, TYR128Z, VAL145S, VAL145Z
• S-a: ASP134S, ASP134a, GLN131S, GLN131a, HIS138S, HIS138a, ILE137S, ILE137a, TYR128S, TYR128a
• S-H: ARG22S, GLU162H, GLU165H, GLU26S, GLU8S, LEU155H, LEU161H, LYS25S, LYS57S
• S-s: ALA705s, ARG111S, ASP58S, CYS91S, GLU26S, HIS191S, ILE59S, ILE63S, ILE90S, LEU114S, LEU189S, LEU23S, LEU61S, LYS110S, MET92S, PHE112S, PHE30S, PHE701s, PRO115S, PRO703s, SER702s, SER88S, THR190S, THR89S, TYR60S, TYR62S, VAL28S
• S-t: ALA45S, ALA52S, ALA705t, ASN41S, ASP78S, GLN81S, GLU51S, ILE76S, ILE83S, LEU48S, LYS84S, MET47S, MET80S, PHE701t, PHE82S, PRO55S, PRO703t, SER702t, SER75S, THR79S, VAL44S
• T-U: ALA132T, ALA139T, ALA176U, ALA40T, ALA45T, ALA52T, ALA72T, ALA95U, ALA96U, ARG118U, ARG140T, ARG148T, ARG15T, ARG15U, ARG170U, ARG172U, ARG22T, ARG22U, ASN116U, ASN41T, ASN64U, ASP134T, ASP171U, ASP18T, ASP18U, ASP37T, ASP78T, CYS113U, CYS91U, GLN131T, GLN34U, GLN46T, GLN81T, GLN94U, GLN9T, GLN9U, GLU136T, GLU141T, GLU14T, GLU14U, GLU169U, GLU178U, GLU26U, GLU36T, GLU51T, GLU53T, GLU8T, GLU8U, GLY130T, GLY33U, GLY73T, GLY93U, HIS122U, HIS138T, HIS156T, HIS191U, HIS38T, ILE121U, ILE135T, ILE137T, ILE142T, ILE188U, ILE19T, ILE19U, ILE29T, ILE43T, ILE63U, ILE70T, ILE76T, ILE7U, ILE83T, ILE90U, LEU114U, LEU152T, LEU155T, LEU174U, LEU189U, LEU23T, LEU23U, LEU24T, LEU2U, LEU31U, LEU42T, LEU48T, LEU50T, LYS144T, LYS146T, LYS25T, LYS84T, MET120U, MET149T, MET39T, MET39U, MET47T, MET5T, MET5U, MET74T, MET80T, MET92U, PHE101T, PHE173U, PHE17T, PHE17U, PHE30T, PHE30U, PHE49T, PHE82T, PRO115U, PRO177U, PRO4T, PRO4U, PRO66U, SER117U, SER16T, SER16U, SER175U, SER21T, SER65U, SER75T, THR133T, THR190U, THR32U, THR71T, THR79T, TYR128T, TYR20T, TYR20U, TYR62U, TYR77T, VAL119U, VAL145T, VAL28U, VAL3T, VAL3U, VAL44T, VAL69T, VAL6U
• T-O: LEU2O, LEU42T
• T-Z: ARG170T, ARG170Z, ASP171T, ASP171Z, GLN123T, GLN123Z, GLU169T, GLU169Z, HIS122T, HIS122Z, LYS146T, LYS146Z, THR168T, THR168Z
• T-a: ALA132T, ALA132a, ALA139T, ALA139a, ARG140T, ARG140a, ARG170T, ARG170a, ASN150T, ASN150a, ASP134T, ASP134a, ASP171T, ASP171a, GLN123T, GLN123a, GLN129T, GLN129a, GLN131T, GLN131a, GLU136T, GLU136a, GLU141T, GLU141a, GLU169T, GLU169a, GLY126T, GLY126a, GLY127T, GLY127a, GLY130T, GLY130a, GLY147T, GLY147a, HIS122T, HIS122a, HIS138T, HIS138a, ILE121T, ILE121a, ILE135T, ILE135a, ILE137T, ILE137a, ILE142T, ILE142a, ILE70T, ILE70a, LEU125T, LEU125a, LEU143T, LEU143a, LYS144T, LYS144a, LYS146T, LYS146a, MET120T, MET120a, PRO124T, PRO124a, THR133T, THR133a, THR168T, THR168a, TYR128T, TYR128a, VAL145T, VAL145a
• T-b: ASP134T, ASP134b, GLN131T, GLN131b, HIS138T, HIS138b, ILE137T, ILE137b, TYR128T, TYR128b
• T-t: ALA705t, ARG111T, ASP58T, CYS91T, GLU26T, HIS191T, ILE59T, ILE63T, ILE90T, LEU114T, LEU189T, LEU23T, LEU61T, LYS110T, MET92T, PHE112T, PHE30T, PHE701t, PRO115T, PRO703t, SER702t, SER88T, THR190T, THR89T, TYR60T, TYR62T, VAL28T
• T-u: ALA45T, ALA52T, ALA705u, ASN41T, ASP78T, GLU51T, ILE76T, ILE83T, LEU48T, LYS84T, MET47T, MET80T, PHE701u, PHE82T, PRO55T, PRO703u, SER702u, SER75T, THR79T, VAL44T
• U-O: ALA132U, ALA139U, ALA176O, ALA40U, ALA45U, ALA52U, ALA72U, ALA95O, ALA96O, ARG118O, ARG140U, ARG148U, ARG15O, ARG15U, ARG170O, ARG172O, ARG22O, ARG22U, ASN116O, ASN41U, ASN64O, ASP134U, ASP171O, ASP18O, ASP18U, ASP37U, ASP78U, CYS113O, CYS91O, GLN131U, GLN34O, GLN46U, GLN81U, GLN94O, GLN9O, GLU136U, GLU141U, GLU14O, GLU151U, GLU169O, GLU178O, GLU26O, GLU36U, GLU53U, GLU8O, GLU8U, GLY130U, GLY33O, GLY73U, GLY93O, HIS122O, HIS138U, HIS156U, HIS38U, ILE121O, ILE135U, ILE137U, ILE142U, ILE188O, ILE19O, ILE19U, ILE29O, ILE29U, ILE43U, ILE63O, ILE70U, ILE76U, ILE7O, ILE83U, ILE90O, LEU114O, LEU152U, LEU174O, LEU189O, LEU23O, LEU24U, LEU2O, LEU2U, LEU31O, LEU42U, LEU48U, LEU50U, LYS144U, LYS146U, LYS25U, MET120O, MET149U, MET39O, MET39U, MET47U, MET5O, MET5U, MET74U, MET80U, MET92O, PHE101U, PHE112O, PHE173O, PHE17O, PHE17U, PHE30O, PHE30U, PHE49U, PHE82U, PRO115O, PRO177O, PRO4O, PRO4U, PRO66O, SER117O, SER16O, SER16U, SER175O, SER21U, SER65O, SER75U, THR133U, THR190O, THR32O, THR71U, THR79U, TYR128U, TYR20O, TYR20U, TYR62O, TYR77U, VAL119O, VAL145U, VAL28O, VAL3O, VAL3U, VAL44U, VAL69U, VAL6O
• U-P: LEU2P, LEU42U
• U-a: ARG170U, ARG170a, ASP171U, ASP171a, GLN123U, GLN123a, GLU169U, GLU169a, HIS122U, HIS122a, LYS146U, LYS146a, THR168U, THR168a
• U-b: ALA132U, ALA132b, ALA139U, ALA139b, ARG140U, ARG140b, ARG170U, ARG170b, ASN150U, ASN150b, ASP134U, ASP134b, ASP171U, ASP171b, GLN123U, GLN123b, GLN129U, GLN129b, GLN131U, GLN131b, GLU136U, GLU136b, GLU141U, GLU141b, GLU169U, GLU169b, GLY126U, GLY126b, GLY127U, GLY127b, GLY130U, GLY130b, GLY147U, GLY147b, HIS122U, HIS122b, HIS138U, HIS138b, ILE121U, ILE121b, ILE135U, ILE135b, ILE137U, ILE137b, ILE142U, ILE142b, ILE70U, ILE70b, LEU125U, LEU125b, LEU143U, LEU143b, LYS144U, LYS144b, LYS146U, LYS146b, MET120b, PRO124U, PRO124b, THR133U, THR133b, THR168U, THR168b, TYR128U, TYR128b, VAL145U, VAL145b
• U-V: ASP134U, ASP134V, GLN131U, GLN131V, HIS138U, HIS138V, ILE137U, ILE137V, TYR128U, TYR128V
• U-o: ALA45U, ALA52U, ALA705o, ASN41U, ASP78U, GLU51U, ILE76U, ILE83U, LEU48U, LYS84U, MET47U, MET80U, PHE701o, PHE82U, PRO55U, PRO703o, SER702o, SER75U, THR79U, VAL44U
• U-u: ALA705u, ARG111U, ASP58U, CYS91U, HIS191U, ILE59U, ILE63U, ILE90U, LEU114U, LEU189U, LEU23U, LEU61U, LYS110U, MET92U, PHE112U, PHE30U, PHE701u, PRO115U, PRO703u, SER702u, SER88U, THR190U, THR89U, TYR60U, TYR62U, VAL28U
• O-P: ALA132O, ALA139O, ALA176P, ALA40O, ALA45O, ALA52O, ALA72O, ALA95P, ALA96P, ARG118P, ARG12O, ARG12P, ARG140O, ARG148O, ARG15O, ARG15P, ARG170P, ARG172P, ARG22O, ARG22P, ASN116P, ASN41O, ASN64P, ASP134O, ASP171P, ASP18O, ASP18P, ASP37O, ASP78O, CYS113P, CYS91P, GLN131O, GLN34P, GLN46O, GLN81O, GLN94P, GLN9P, GLU136O, GLU141O, GLU14P, GLU151O, GLU169P, GLU178P, GLU26P, GLU36O, GLU53O, GLU8O, GLU8P, GLY130O, GLY13O, GLY13P, GLY33P, GLY73O, GLY93P, HIS122P, HIS138O, HIS156O, HIS191P, HIS38O, ILE121P, ILE135O, ILE137O, ILE142O, ILE188P, ILE19O, ILE19P, ILE29O, ILE29P, ILE43O, ILE63P, ILE70O, ILE76O, ILE7P, ILE83O, ILE90P, LEU114P, LEU152O, LEU174P, LEU189P, LEU23O, LEU23P, LEU24O, LEU2P, LEU31P, LEU42O, LEU48O, LEU50O, LYS144O, LYS146O, LYS25O, LYS84O, MET120P, MET149O, MET39O, MET39P, MET47O, MET5O, MET5P, MET74O, MET80O, MET92P, PHE101O, PHE173P, PHE17O, PHE17P, PHE30O, PHE30P, PHE49O, PHE82O, PRO115P, PRO124O, PRO177P, PRO4O, PRO4P, PRO66P, SER117P, SER16O, SER16P, SER175P, SER21O, SER65P, SER75O, THR10O, THR133O, THR190P, THR32P, THR71O, THR79O, TYR128O, TYR20O, TYR20P, TYR62P, TYR77O, VAL119P, VAL145O, VAL28P, VAL35O, VAL3O, VAL3P, VAL44O, VAL69O, VAL6P
• O-b: ARG170O, ARG170b, ASP171O, ASP171b, GLN123O, GLN123b, GLU169O, GLU169b, HIS122O, HIS122b, LYS146O, LYS146b, THR168O, THR168b
• O-V: ALA132O, ALA132V, ALA139O, ALA139V, ARG140O, ARG140V, ARG170O, ARG170V, ASN150O, ASN150V, ASP134O, ASP134V, ASP171O, ASP171V, GLN123O, GLN123V, GLN129O, GLN129V, GLN131O, GLN131V, GLU136O, GLU136V, GLU141O, GLU141V, GLU169O, GLU169V, GLY126O, GLY126V, GLY127O, GLY127V, GLY130O, GLY130V, GLY147O, GLY147V, HIS122O, HIS122V, HIS138O, HIS138V, ILE121O, ILE121V, ILE135O, ILE135V, ILE137O, ILE137V, ILE142O, ILE142V, ILE70O, ILE70V, LEU125O, LEU125V, LEU143O, LEU143V, LYS144O, LYS144V, LYS146O, LYS146V, MET120O, PRO124O, PRO124V, THR133O, THR133V, THR168O, THR168V, TYR128O, TYR128V, VAL145O, VAL145V
• O-W: ASP134O, ASP134W, GLN131O, GLN131W, HIS138O, HIS138W, ILE137O, ILE137W, TYR128O, TYR128W
• O-A: ARG12O, ARG166A, GLU162A, GLU165A, LEU161A, SER11O
• O-o: ALA705o, ARG111O, ASP58O, CYS91O, GLU26O, ILE59O, ILE63O, ILE90O, LEU114O, LEU189O, LEU23O, LEU61O, LYS110O, MET92O, PHE112O, PHE30O, PHE701o, PRO115O, PRO703o, SER702o, SER88O, THR190O, THR89O, TYR60O, TYR62O, VAL28O
• O-p: ALA45O, ALA52O, ALA705p, ASP78O, GLN81O, GLU51O, ILE76O, ILE83O, LEU48O, LYS84O, MET47O, MET80O, PHE701p, PHE82O, PRO55O, PRO703p, SER702p, SER75O, THR79O, VAL44O
• P-Q: ALA132P, ALA139P, ALA176Q, ALA40P, ALA45P, ALA52P, ALA72P, ALA95Q, ALA96Q, ARG118Q, ARG12P, ARG140P, ARG148P, ARG15P, ARG15Q, ARG170Q, ARG172Q, ARG22P, ARG22Q, ASN116Q, ASN41P, ASN64Q, ASP134P, ASP171Q, ASP18P, ASP18Q, ASP37P, ASP78P, CYS113Q, CYS91Q, GLN131P, GLN34Q, GLN46P, GLN81P, GLN94Q, GLN9Q, GLU136P, GLU141P, GLU14P, GLU14Q, GLU151P, GLU169Q, GLU178Q, GLU26Q, GLU36P, GLU51P, GLU53P, GLU8P, GLU8Q, GLY130P, GLY13P, GLY13Q, GLY33Q, GLY73P, GLY93Q, HIS122Q, HIS138P, HIS156P, HIS191Q, HIS38P, ILE121Q, ILE135P, ILE137P, ILE142P, ILE188Q, ILE19Q, ILE29P, ILE29Q, ILE43P, ILE63Q, ILE70P, ILE76P, ILE7Q, ILE83P, ILE90Q, LEU114Q, LEU152P, LEU174Q, LEU189Q, LEU23P, LEU23Q, LEU24P, LEU31Q, LEU42P, LEU48P, LEU50P, LYS144P, LYS146P, LYS25P, LYS84P, MET120Q, MET149P, MET39P, MET39Q, MET47P, MET5P, MET5Q, MET74P, MET80P, MET92Q, PHE101P, PHE112Q, PHE173Q, PHE17P, PHE17Q, PHE30P, PHE30Q, PHE49P, PHE82P, PRO115Q, PRO124P, PRO177Q, PRO4Q, PRO66Q, SER117Q, SER16P, SER16Q, SER175Q, SER21P, SER65Q, SER75P, THR10P, THR10Q, THR133P, THR190Q, THR32Q, THR71P, THR79P, TYR128P, TYR20P, TYR20Q, TYR62Q, TYR77P, VAL119Q, VAL145P, VAL28Q, VAL35Q, VAL3P, VAL3Q, VAL44P, VAL69P, VAL6Q
• P-V: ARG170P, ARG170V, ASP171P, ASP171V, GLN123P, GLN123V, GLU169P, GLU169V, HIS122P, HIS122V, LYS146P, LYS146V, THR168P, THR168V
• P-W: ALA132P, ALA132W, ALA139P, ALA139W, ARG140P, ARG140W, ARG170P, ARG170W, ASN150P, ASN150W, ASP134P, ASP134W, ASP171P, ASP171W, GLN123P, GLN123W, GLN129P, GLN129W, GLN131P, GLN131W, GLU136P, GLU136W, GLU141P, GLU141W, GLU169P, GLU169W, GLY126P, GLY126W, GLY127P, GLY127W, GLY130P, GLY130W, GLY147P, GLY147W, HIS122P, HIS122W, HIS138P, HIS138W, ILE121P, ILE121W, ILE135P, ILE135W, ILE137P, ILE137W, ILE142P, ILE142W, ILE70P, ILE70W, LEU125P, LEU125W, LEU143P, LEU143W, LYS144P, LYS144W, LYS146P, LYS146W, PRO124P, PRO124W, THR133P, THR133W, THR168P, THR168W, TYR128P, TYR128W, VAL145P, VAL145W
• P-X: ASP134P, ASP134X, GLN131P, GLN131X, HIS138P, HIS138X, ILE137P, ILE137X, TYR128P, TYR128X
• P-A: ALA154A, ARG12P, ARG15P, ASN150A, GLN159A, GLN163A, GLU14P, GLU151A, GLU162A, GLU165A, GLY13P, GLY147A, GLY158A, ILE164A, LEU155A, LEU161A, SER11P, SER160A, THR10P
• P-p: ALA705p, ARG111P, ASP58P, CYS91P, GLU26P, HIS191P, ILE59P, ILE63P, ILE90P, LEU114P, LEU189P, LEU23P, LEU61P, LYS110P, MET92P, PHE112P, PHE30P, PHE701p, PRO115P, PRO703p, SER702p, SER88P, THR190P, THR89P, TYR60P, TYR62P, VAL28P
• P-q: ALA45P, ALA52P, ALA705q, ASP78P, GLN81P, GLU51P, ILE76P, ILE83P, LEU48P, LYS84P, MET47P, MET80P, PHE701q, PHE82P, PRO55P, PRO703q, SER702q, SER75P, THR79P, VAL44P
• Q-Y: ASP134Q, ASP134Y, GLN131Q, GLN131Y, HIS138Q, HIS138Y, ILE137Q, ILE137Y, TYR128Q, TYR128Y
• Q-W: ARG170Q, ARG170W, ASP171Q, ASP171W, GLN123Q, GLN123W, GLU169Q, GLU169W, HIS122Q, HIS122W, LEU125W, LYS146Q, LYS146W, THR168Q, THR168W
• Q-X: ALA132Q, ALA132X, ALA139Q, ALA139X, ARG140Q, ARG140X, ARG170Q, ARG170X, ASN150Q, ASN150X, ASP134Q, ASP134X, ASP171Q, ASP171X, GLN123Q, GLN123X, GLN129Q, GLN129X, GLN131Q, GLN131X, GLU136Q, GLU136X, GLU141Q, GLU141X, GLU169Q, GLU169X, GLY126Q, GLY126X, GLY127Q, GLY127X, GLY130Q, GLY130X, GLY147Q, GLY147X, HIS122Q, HIS122X, HIS138Q, HIS138X, ILE121Q, ILE121X, ILE135Q, ILE135X, ILE137Q, ILE137X, ILE142Q, ILE142X, ILE70Q, ILE70X, LEU125Q, LEU125X, LEU143Q, LEU143X, LYS144Q, LYS144X, LYS146Q, LYS146X, MET120Q, MET120X, PRO124Q, PRO124X, THR133Q, THR133X, THR168Q, THR168X, TYR128Q, TYR128X, VAL145Q, VAL145X
• Q-B: ALA154B, ALA179B, ALA52Q, ARG111B, ARG166B, ARG22Q, ARG27Q, ASN54Q, ASP186B, GLN159B, GLN163B, GLN9Q, GLU178B, GLU181B, GLU26Q, GLU51Q, GLU53Q, GLU56Q, GLU8Q, GLY158B, GLY183B, HIS156B, ILE164B, LEU155B, LEU161B, LEU184B, LEU50Q, LYS108B, LYS25Q, LYS57Q, LYS84Q, PRO177B, PRO55Q, SER160B, SER175B, SER187B, THR10Q, THR157B, TYR182B, VAL180B, VAL185B
• Q-A: ARG148A, GLN9Q, GLU14Q, GLU151A, GLY13Q, GLY147A, LEU161A, LYS144A, THR10Q
• Q-q: ALA705q, ARG111Q, ASP58Q, CYS91Q, GLU26Q, HIS191Q, ILE59Q, ILE63Q, ILE90Q, LEU114Q, LEU189Q, LEU23Q, LEU61Q, LYS110Q, MET92Q, PHE112Q, PHE30Q, PHE701q, PRO115Q, PRO703q, SER702q, SER88Q, THR190Q, THR89Q, TYR60Q, TYR62Q, VAL28Q
• Q-r: ALA45Q, ALA52Q, ALA705r, ASN41Q, ASP78Q, GLN81Q, GLU51Q, ILE76Q, ILE83Q, LEU48Q, LYS84Q, MET47Q, MET80Q, PHE701r, PHE82Q, PRO55Q, PRO703r, SER702r, SER75Q, THR79Q, VAL44Q
• Y-Z: ALA132Z, ALA139Z, ALA176Y, ALA40Z, ALA45Z, ALA52Z, ALA72Z, ALA95Y, ALA96Y, ARG118Y, ARG140Z, ARG148Z, ARG15Y, ARG170Y, ARG172Y, ARG22Y, ARG22Z, ASN116Y, ASN41Z, ASN64Y, ASP134Z, ASP171Y, ASP18Y, ASP18Z, ASP37Z, ASP78Z, CYS113Y, CYS91Y, GLN131Z, GLN34Y, GLN46Z, GLN81Z, GLN94Y, GLN9Y, GLU136Z, GLU141Z, GLU151Z, GLU169Y, GLU178Y, GLU26Y, GLU36Z, GLU51Z, GLU53Z, GLU8Y, GLU8Z, GLY130Z, GLY33Y, GLY73Z, GLY93Y, HIS122Y, HIS138Z, HIS156Z, HIS191Y, HIS38Z, ILE121Y, ILE135Z, ILE137Z, ILE142Z, ILE188Y, ILE19Y, ILE19Z, ILE29Y, ILE29Z, ILE43Z, ILE63Y, ILE70Z, ILE76Z, ILE7Y, ILE83Z, ILE90Y, LEU114Y, LEU125Y, LEU152Z, LEU155Z, LEU174Y, LEU189Y, LEU23Y, LEU23Z, LEU24Z, LEU2Y, LEU2Z, LEU31Y, LEU42Z, LEU48Z, LEU50Z, LYS144Z, LYS146Z, LYS25Z, LYS84Z, MET120Y, MET149Z, MET39Y, MET39Z, MET47Z, MET5Y, MET5Z, MET74Z, MET80Z, MET92Y, PHE101Z, PHE112Y, PHE173Y, PHE17Y, PHE17Z, PHE30Y, PHE30Z, PHE49Z, PHE82Z, PRO115Y, PRO177Y, PRO4Y, PRO4Z, PRO66Y, SER117Y, SER16Y, SER16Z, SER175Y, SER21Z, SER65Y, SER75Z, THR133Z, THR190Y, THR32Y, THR71Z, THR79Z, TYR128Z, TYR20Y, TYR20Z, TYR62Y, TYR77Z, VAL119Y, VAL145Z, VAL28Y, VAL3Y, VAL3Z, VAL44Z, VAL69Z, VAL6Y
• Y-a: LEU2Y, LEU42a
• Y-W: LEU2W, LEU42Y
• Y-X: ALA132Y, ALA139Y, ALA176X, ALA40Y, ALA45Y, ALA52Y, ALA72Y, ALA95X, ALA96X, ARG118X, ARG140Y, ARG148Y, ARG15X, ARG15Y, ARG170X, ARG172X, ARG22X, ARG22Y, ASN116X, ASN41Y, ASN64X, ASP134Y, ASP171X, ASP18X, ASP18Y, ASP37Y, ASP78Y, CYS113X, CYS91X, GLN131Y, GLN34X, GLN46Y, GLN81Y, GLN94X, GLN9X, GLU136Y, GLU141Y, GLU14X, GLU151Y, GLU169X, GLU178X, GLU26X, GLU36Y, GLU51Y, GLU53Y, GLU8X, GLU8Y, GLY130Y, GLY33X, GLY73Y, GLY93X, HIS122X, HIS138Y, HIS156Y, HIS191X, HIS38Y, ILE121X, ILE135Y, ILE137Y, ILE142Y, ILE188X, ILE19X, ILE19Y, ILE29Y, ILE43Y, ILE63X, ILE70Y, ILE76Y, ILE7X, ILE83Y, ILE90X, LEU114X, LEU125X, LEU152Y, LEU155Y, LEU174X, LEU189X, LEU23X, LEU23Y, LEU24Y, LEU2X, LEU2Y, LEU31X, LEU42Y, LEU48Y, LEU50Y, LYS144Y, LYS146Y, LYS25Y, LYS84Y, MET120X, MET149Y, MET39X, MET39Y, MET47Y, MET5X, MET5Y, MET74Y, MET80Y, MET92X, PHE101Y, PHE112X, PHE173X, PHE17X, PHE17Y, PHE30X, PHE30Y, PHE49Y, PHE82Y, PRO115X, PRO177X, PRO4X, PRO4Y, PRO66X, SER117X, SER16X, SER16Y, SER175X, SER21Y, SER65X, SER75Y, THR10Y, THR133Y, THR190X, THR32X, THR71Y, THR79Y, TYR128Y, TYR20X, TYR20Y, TYR60X, TYR62X, TYR77Y, VAL119X, VAL145Y, VAL28X, VAL3X, VAL3Y, VAL44Y, VAL69Y, VAL6X
• Y-x: ALA45Y, ALA52Y, ALA705x, ASP78Y, GLN81Y, GLU51Y, ILE76Y, ILE83Y, LEU48Y, LYS84Y, MET47Y, MET80Y, PHE701x, PHE82Y, PRO55Y, PRO703x, SER702x, SER75Y, THR79Y, TYR77Y, VAL44Y
• Y-y: ALA705y, ARG111Y, ASP58Y, CYS91Y, GLU26Y, GLY93Y, HIS191Y, ILE59Y, ILE63Y, ILE90Y, LEU114Y, LEU189Y, LEU23Y, LEU61Y, LYS110Y, MET92Y, PHE112Y, PHE30Y, PHE701y, PRO115Y, PRO703y, SER702y, SER88Y, THR190Y, THR89Y, TYR60Y, TYR62Y, VAL28Y
• Z-a: ALA132a, ALA139a, ALA176Z, ALA40a, ALA45a, ALA52a, ALA72a, ALA95Z, ALA96Z, ARG118Z, ARG140a, ARG148a, ARG170Z, ARG172Z, ARG22Z, ARG22a, ASN116Z, ASN41a, ASN64Z, ASP134a, ASP171Z, ASP18Z, ASP18a, ASP37a, ASP78a, CYS113Z, CYS91Z, GLN131a, GLN34Z, GLN46a, GLN81a, GLN94Z, GLU136a, GLU141a, GLU169Z, GLU178Z, GLU26Z, GLU36a, GLU51a, GLU53a, GLU8Z, GLY130a, GLY33Z, GLY67Z, GLY73a, GLY93Z, HIS122Z, HIS138a, HIS156a, HIS191Z, HIS38a, ILE121Z, ILE135a, ILE137a, ILE142a, ILE188Z, ILE19Z, ILE19a, ILE29Z, ILE29a, ILE43a, ILE63Z, ILE70a, ILE76a, ILE7Z, ILE83a, ILE90Z, LEU114Z, LEU125Z, LEU152a, LEU155a, LEU174Z, LEU189Z, LEU23Z, LEU24a, LEU2Z, LEU31Z, LEU42a, LEU48a, LEU50a, LYS144a, LYS146a, LYS25a, LYS84a, MET120Z, MET149a, MET39Z, MET39a, MET47a, MET5Z, MET5a, MET74a, MET80a, MET92Z, PHE101a, PHE173Z, PHE17Z, PHE17a, PHE30Z, PHE30a, PHE49a, PHE82a, PRO115Z, PRO177Z, PRO4Z, PRO4a, PRO66Z, SER117Z, SER16Z, SER16a, SER175Z, SER21a, SER65Z, SER75a, THR133a, THR190Z, THR32Z, THR71a, THR79a, TYR128a, TYR20Z, TYR20a, TYR62Z, TYR77a, VAL119Z, VAL145a, VAL28Z, VAL28a, VAL3Z, VAL3a, VAL44a, VAL69a, VAL6Z
• Z-b: LEU2Z, LEU42b
• Z-X: LEU2X, LEU42Z
• Z-y: ALA45Z, ALA52Z, ALA705y, ASP78Z, GLN81Z, GLU51Z, ILE76Z, ILE83Z, LEU48Z, LYS84Z, MET47Z, MET80Z, PHE701y, PHE82Z, PRO55Z, PRO703y, SER702y, SER75Z, THR79Z, VAL44Z
• Z-z: ALA705z, ARG111Z, ASP58Z, CYS91Z, GLU26Z, GLY93Z, HIS191Z, ILE59Z, ILE63Z, ILE90Z, LEU114Z, LEU189Z, LEU23Z, LEU61Z, LYS110Z, MET92Z, PHE112Z, PHE30Z, PHE701z, PRO115Z, PRO703z, SER702z, SER88Z, THR190Z, THR89Z, TYR60Z, TYR62Z, VAL28Z
• a-b: ALA132b, ALA139b, ALA176a, ALA40b, ALA45b, ALA52b, ALA72b, ALA95a, ALA96a, ARG118a, ARG140b, ARG148b, ARG170a, ARG172a, ARG192a, ARG22a, ARG22b, ASN116a, ASN193a, ASN41b, ASN64a, ASP134b, ASP171a, ASP18a, ASP18b, ASP37b, ASP78b, ASP86b, CYS113a, CYS91a, GLN131b, GLN34a, GLN46b, GLN81b, GLN94a, GLU136b, GLU141b, GLU151b, GLU169a, GLU178a, GLU26a, GLU36b, GLU51b, GLU53b, GLY130b, GLY33a, GLY73b, GLY93a, HIS122a, HIS138b, HIS156b, HIS191a, HIS38b, ILE121a, ILE135b, ILE137b, ILE142b, ILE188a, ILE19a, ILE29b, ILE43b, ILE63a, ILE70b, ILE76b, ILE7a, ILE83b, ILE90a, LEU114a, LEU125a, LEU143b, LEU152b, LEU174a, LEU189a, LEU23a, LEU23b, LEU24b, LEU31a, LEU42b, LEU48b, LEU50b, LYS144b, LYS25b, LYS84b, MET120a, MET149b, MET39a, MET39b, MET47b, MET5a, MET5b, MET74b, MET80b, MET92a, PHE101b, PHE112a, PHE173a, PHE17a, PHE17b, PHE30a, PHE30b, PHE49b, PHE82b, PRO115a, PRO124b, PRO177a, PRO4a, PRO66a, PRO85b, SER117a, SER16a, SER175a, SER21b, SER65a, SER75b, THR133b, THR190a, THR32a, THR71b, THR79b, TYR128b, TYR20a, TYR20b, TYR62a, TYR77b, VAL119a, VAL145b, VAL28a, VAL3a, VAL3b, VAL44b, VAL69b, VAL6a
• a-z: ALA45a, ALA52a, ALA705z, ASP78a, GLN81a, GLU51a, ILE76a, ILE83a, LEU48a, LYS84a, MET47a, MET80a, PHE701z, PHE82a, PRO55a, PRO703z, SER702z, SER75a, THR79a, VAL44a
• a-3: ALA7053, ARG111a, ARG192a, ASN193a, ASP58a, CYS91a, GLU26a, GLY93a, HIS191a, ILE59a, ILE63a, ILE90a, LEU114a, LEU189a, LEU23a, LEU61a, LYS110a, MET92a, PHE112a, PHE30a, PHE7013, PRO115a, PRO7033, SER7023, SER88a, THR190a, THR89a, TYR60a, TYR62a, VAL28a
• b-V: ALA132V, ALA139V, ALA176b, ALA40V, ALA45V, ALA52V, ALA72V, ALA95b, ALA96b, ARG118b, ARG140V, ARG148V, ARG170b, ARG172b, ARG22V, ARG22b, ASN116b, ASN41V, ASN64b, ASP134V, ASP171b, ASP18V, ASP18b, ASP37V, ASP78V, CYS113b, CYS91b, GLN131V, GLN34b, GLN46V, GLN81V, GLN94b, GLU136V, GLU141V, GLU151V, GLU169b, GLU178b, GLU26b, GLU36V, GLU53V, GLY130V, GLY33b, GLY67b, GLY73V, GLY93b, HIS122b, HIS138V, HIS156V, HIS191b, HIS38V, ILE121b, ILE135V, ILE137V, ILE142V, ILE188b, ILE19V, ILE19b, ILE29V, ILE29b, ILE43V, ILE63b, ILE70V, ILE76V, ILE83V, ILE90b, LEU114b, LEU152V, LEU174b, LEU189b, LEU23V, LEU23b, LEU24V, LEU2b, LEU31b, LEU42V, LEU48V, LEU50V, LYS144V, LYS146V, LYS25V, LYS84V, MET120b, MET149V, MET39V, MET39b, MET47V, MET5V, MET5b, MET74V, MET80V, MET92b, PHE101V, PHE112b, PHE173b, PHE17V, PHE17b, PHE30V, PHE30b, PHE49V, PHE82V, PRO115b, PRO124V, PRO177b, PRO4V, PRO4b, PRO66b, SER117b, SER16V, SER175b, SER21V, SER65b, SER75V, THR133V, THR190b, THR32b, THR71V, THR79V, TYR128V, TYR20V, TYR20b, TYR62b, TYR77V, VAL119b, VAL145V, VAL28b, VAL3V, VAL3b, VAL44V, VAL69V, VAL6b
• b-W: LEU2b, LEU42W
• b-3: ALA45b, ALA52b, ALA7053, ASP78b, GLU51b, ILE76b, ILE83b, LEU48b, LYS84b, MET47b, MET80b, PHE7013, PHE82b, PRO55b, PRO7033, SER7023, SER75b, THR79b, VAL44b
• b-4: ALA7054, ARG111b, ASP58b, CYS91b, GLU26b, HIS191b, ILE59b, ILE63b, ILE90b, LEU114b, LEU189b, LEU23b, LEU61b, LYS110b, MET92b, PHE112b, PHE30b, PHE7014, PRO115b, PRO7034, SER7024, SER88b, THR190b, THR89b, TYR60b, TYR62b, VAL28b
• V-W: ALA132W, ALA139W, ALA176V, ALA40W, ALA45W, ALA52W, ALA72W, ALA95V, ALA96V, ARG118V, ARG140W, ARG148W, ARG15V, ARG170V, ARG172V, ARG22V, ARG22W, ASN116V, ASN41W, ASN64V, ASP134W, ASP171V, ASP18V, ASP18W, ASP37W, ASP78W, CYS113V, CYS91V, GLN131W, GLN34V, GLN46W, GLN81W, GLN94V, GLU136W, GLU141W, GLU151W, GLU169V, GLU178V, GLU26V, GLU36W, GLU53W, GLU8V, GLY130W, GLY33V, GLY73W, GLY93V, HIS122V, HIS138W, HIS156W, HIS191V, HIS38W, ILE121V, ILE135W, ILE137W, ILE142W, ILE188V, ILE19V, ILE29W, ILE43W, ILE63V, ILE70W, ILE76W, ILE7V, ILE83W, ILE90V, LEU114V, LEU125V, LEU152W, LEU174V, LEU189V, LEU23V, LEU24W, LEU31V, LEU42W, LEU48W, LEU50W, LYS144W, LYS146W, LYS25W, LYS84W, MET120V, MET149W, MET39V, MET39W, MET47W, MET5V, MET5W, MET74W, MET80W, MET92V, PHE101W, PHE173V, PHE17V, PHE17W, PHE30V, PHE30W, PHE49W, PHE82W, PRO115V, PRO124W, PRO177V, PRO4V, PRO66V, SER117V, SER16V, SER16W, SER175V, SER21W, SER65V, SER75W, THR133W, THR190V, THR32V, THR71W, THR79W, TYR128W, TYR20V, TYR20W, TYR62V, TYR77W, VAL119V, VAL145W, VAL28V, VAL3V, VAL3W, VAL44W, VAL69W, VAL6V
• V-v: ALA705v, ARG111V, ASP58V, CYS91V, HIS191V, ILE59V, ILE63V, ILE90V, LEU114V, LEU189V, LEU61V, LYS110V, MET92V, PHE112V, PHE30V, PHE701v, PRO115V, PRO703v, SER702v, SER88V, THR190V, THR89V, TYR60V, TYR62V, VAL28V
• V-4: ALA45V, ALA52V, ALA7054, ASP78V, GLN81V, GLU51V, ILE76V, ILE83V, LEU48V, LYS84V, MET47V, MET80V, PHE7014, PHE82V, PRO55V, PRO7034, SER7024, SER75V, THR79V, VAL44V
• W-X: ALA132X, ALA139X, ALA176W, ALA40X, ALA45X, ALA52X, ALA72X, ALA95W, ALA96W, ARG118W, ARG12X, ARG140X, ARG148X, ARG15X, ARG170W, ARG172W, ARG192W, ARG22W, ARG22X, ASN116W, ASN41X, ASN64W, ASP134X, ASP171W, ASP18W, ASP18X, ASP37X, ASP78X, CYS113W, CYS91W, GLN131X, GLN34W, GLN46X, GLN81X, GLN94W, GLU136X, GLU141X, GLU169W, GLU178W, GLU26W, GLU36W, GLU36X, GLU51X, GLU53X, GLU8X, GLY130X, GLY33W, GLY67W, GLY73X, GLY93W, HIS122W, HIS138X, HIS156X, HIS191W, HIS38X, ILE121W, ILE135X, ILE137X, ILE142X, ILE188W, ILE19W, ILE19X, ILE29W, ILE29X, ILE43X, ILE63W, ILE70X, ILE76X, ILE7W, ILE83X, ILE90W, LEU114W, LEU125W, LEU152X, LEU155X, LEU174W, LEU189W, LEU23W, LEU23X, LEU24X, LEU2W, LEU2X, LEU31W, LEU42X, LEU48X, LEU50X, LYS144X, LYS146X, LYS25X, LYS84X, MET120W, MET149X, MET39W, MET39X, MET47X, MET5W, MET5X, MET74X, MET80X, MET92W, PHE101X, PHE112W, PHE173W, PHE17W, PHE17X, PHE30W, PHE30X, PHE49X, PHE82X, PRO115W, PRO124X, PRO177W, PRO4W, PRO4X, PRO55X, PRO66W, PRO85X, SER117W, SER16W, SER16X, SER175W, SER21X, SER65W, SER75X, THR10X, THR133X, THR190W, THR32W, THR71X, THR79X, TYR128X, TYR20W, TYR20X, TYR62W, TYR77X, VAL119W, VAL145X, VAL28W, VAL3W, VAL3X, VAL44X, VAL69X, VAL6W
• W-v: ALA45W, ALA52W, ALA705v, ASN41W, ASP78W, GLN81W, GLU51W, ILE76W, ILE83W, LEU48W, LYS84W, MET47W, MET80W, PHE701v, PHE82W, PRO55W, PRO703v, SER702v, SER75W, THR79W, VAL44W
• W-w: ALA705w, ARG111W, ARG192W, ASP58W, CYS91W, GLU26W, HIS191W, ILE59W, ILE63W, ILE90W, LEU114W, LEU189W, LEU23W, LEU61W, LYS110W, MET92W, PHE112W, PHE30W, PHE701w, PRO115W, PRO703w, SER702w, SER88W, THR190W, THR89W, TYR60W, TYR62W, VAL28W
• X-w: ALA45X, ALA705w, ASN41X, ASP78X, GLN81X, GLU51X, ILE76X, ILE83X, LEU48X, LYS84X, MET47X, MET80X, PHE701w, PHE82X, PRO703w, SER702w, SER75X, THR79X, VAL44X
• X-x: ALA705x, ARG111X, ASP58X, CYS91X, GLU26X, HIS191X, ILE59X, ILE63X, ILE90X, LEU114X, LEU189X, LEU23X, LEU61X, LYS110X, MET92X, PHE112X, PHE30X, PHE701x, PRO115X, PRO703x, SER702x, SER88X, THR190X, THR89X, TYR60X, TYR62X, VAL28X
• M-L: ALA132M, ALA139M, ALA176L, ALA40M, ALA45M, ALA52M, ALA72M, ALA95L, ALA96L, ARG118L, ARG12M, ARG140M, ARG148M, ARG15L, ARG15M, ARG170L, ARG172L, ARG22L, ARG22M, ASN116L, ASN41M, ASN64L, ASP134M, ASP171L, ASP18L, ASP18M, ASP37M, ASP78M, CYS113L, CYS91L, GLN131M, GLN34L, GLN46M, GLN81M, GLN94L, GLN9L, GLU136M, GLU141M, GLU14L, GLU14M, GLU151M, GLU169L, GLU178L, GLU26L, GLU36M, GLU51M, GLU53M, GLU8L, GLU8M, GLY130M, GLY13L, GLY13M, GLY33L, GLY67L, GLY73M, GLY93L, HIS122L, HIS138M, HIS156M, HIS191L, HIS38M, ILE121L, ILE135M, ILE137M, ILE142M, ILE188L, ILE19L, ILE19M, ILE29L, ILE29M, ILE43M, ILE63L, ILE70M, ILE76M, ILE7L, ILE83M, ILE90L, LEU114L, LEU152M, LEU155M, LEU174L, LEU189L, LEU23L, LEU24M, LEU2L, LEU31L, LEU42M, LEU48M, LEU50M, LYS144M, LYS146M, LYS25M, LYS84M, MET120L, MET149M, MET39L, MET39M, MET47M, MET5L, MET5M, MET74M, MET80M, MET92L, PHE101M, PHE112L, PHE173L, PHE17L, PHE17M, PHE30L, PHE30M, PHE49M, PHE82M, PRO115L, PRO177L, PRO4L, PRO66L, SER117L, SER16L, SER16M, SER175L, SER21M, SER65L, SER75M, THR10M, THR133M, THR190L, THR32L, THR71M, THR79M, TYR128M, TYR20L, TYR20M, TYR62L, TYR77M, VAL119L, VAL145M, VAL28L, VAL28M, VAL3L, VAL3M, VAL44M, VAL69M, VAL6L
• M-K: LEU2K, LEU42M
• M-H: LEU2M, LEU42H
• M-N: ALA132N, ALA139N, ALA176M, ALA40N, ALA45N, ALA52N, ALA72N, ALA95M, ALA96M, ARG118M, ARG140N, ARG148N, ARG15M, ARG15N, ARG170M, ARG172M, ARG22M, ARG22N, ASN116M, ASN41N, ASN64M, ASP134N, ASP171M, ASP18M, ASP18N, ASP37N, ASP78N, ASP86N, CYS113M, CYS91M, GLN131N, GLN34M, GLN46N, GLN81N, GLN94M, GLN9M, GLU136N, GLU141N, GLU14M, GLU169M, GLU178M, GLU26M, GLU36N, GLU51N, GLU53N, GLU8M, GLY130N, GLY13M, GLY13N, GLY33M, GLY73N, GLY93M, HIS122M, HIS138N, HIS156N, HIS191M, HIS38N, ILE121M, ILE135N, ILE137N, ILE142N, ILE188M, ILE19M, ILE19N, ILE29N, ILE43N, ILE63M, ILE70N, ILE76N, ILE7M, ILE83N, ILE90M, LEU114M, LEU125M, LEU152N, LEU155N, LEU174M, LEU189M, LEU23M, LEU24N, LEU2M, LEU2N, LEU31M, LEU42N, LEU48N, LEU50N, LYS144N, LYS146N, LYS25N, LYS84N, MET120M, MET149N, MET39M, MET39N, MET47N, MET5M, MET5N, MET74N, MET80N, MET92M, PHE101N, PHE112M, PHE173M, PHE17M, PHE17N, PHE30M, PHE30N, PHE49N, PHE82N, PRO115M, PRO124N, PRO177M, PRO4M, PRO4N, PRO55N, PRO66M, PRO85N, SER117M, SER16M, SER16N, SER175M, SER21N, SER65M, SER75N, THR133N, THR190M, THR32M, THR71N, THR79N, TYR128N, TYR20M, TYR20N, TYR62M, TYR77N, VAL119M, VAL145N, VAL28M, VAL3M, VAL3N, VAL44N, VAL69N, VAL6M
• M-F: ALA132F, ALA132M, ALA139F, ALA139M, ARG140F, ARG140M, ARG170F, ARG170M, ASN150F, ASN150M, ASP134F, ASP134M, ASP171F, ASP171M, GLN123F, GLN123M, GLN129F, GLN129M, GLN131F, GLN131M, GLU136F, GLU136M, GLU141F, GLU141M, GLU169F, GLU169M, GLY126F, GLY126M, GLY127F, GLY127M, GLY130F, GLY130M, GLY147F, GLY147M, HIS122F, HIS122M, HIS138F, HIS138M, ILE121F, ILE121M, ILE135F, ILE135M, ILE137F, ILE137M, ILE142F, ILE142M, ILE70F, ILE70M, LEU125F, LEU125M, LEU143F, LEU143M, LYS144F, LYS144M, LYS146F, LYS146M, PRO124F, PRO124M, THR133F, THR133M, THR168F, THR168M, TYR128F, TYR128M, VAL145F, VAL145M
• M-E: ASP134E, ASP134M, GLN131E, GLN131M, HIS138E, HIS138M, ILE137E, ILE137M, TYR128E, TYR128M
• M-G: ARG170G, ARG170M, ASP171G, ASP171M, GLN123G, GLN123M, GLU169G, GLU169M, HIS122G, HIS122M, LYS146G, LYS146M, THR168G, THR168M
• M-l: ALA45M, ALA52M, ALA705l, ASP78M, GLN81M, GLU51M, ILE76M, ILE83M, LEU48M, LYS84M, MET47M, MET80M, PHE701l, PHE82M, PRO55M, PRO703l, SER702l, SER75M, THR79M, VAL44M
• M-m: ALA705m, ARG111M, ASP58M, CYS91M, GLU26M, HIS191M, ILE59M, ILE90M, LEU114M, LEU189M, LEU23M, LEU61M, LYS110M, MET92M, PHE112M, PHE30M, PHE701m, PRO115M, PRO703m, SER702m, SER88M, THR190M, THR89M, TYR60M, TYR62M, VAL28M
• L-K: ALA132L, ALA139L, ALA176K, ALA40L, ALA45L, ALA52L, ALA72L, ALA95K, ALA96K, ARG118K, ARG140L, ARG148L, ARG15K, ARG15L, ARG170K, ARG172K, ARG22K, ARG22L, ASN116K, ASN41L, ASN64K, ASP134L, ASP171K, ASP18K, ASP18L, ASP37L, ASP78L, CYS113K, CYS91K, GLN131L, GLN34K, GLN46L, GLN81L, GLN94K, GLN9K, GLU136L, GLU141L, GLU14K, GLU14L, GLU169K, GLU178K, GLU26K, GLU36L, GLU51L, GLU53L, GLU8K, GLU8L, GLY130L, GLY13L, GLY33K, GLY73L, GLY93K, HIS122K, HIS138L, HIS156L, HIS191K, HIS38L, ILE121K, ILE135L, ILE137L, ILE142L, ILE188K, ILE19K, ILE19L, ILE29K, ILE29L, ILE43L, ILE63K, ILE70L, ILE76L, ILE7K, ILE83L, ILE90K, LEU114K, LEU152L, LEU155L, LEU174K, LEU189K, LEU23K, LEU23L, LEU24L, LEU2K, LEU31K, LEU42L, LEU48L, LEU50L, LYS144L, LYS146L, LYS25L, LYS84L, MET120K, MET149L, MET39K, MET39L, MET47L, MET5K, MET5L, MET74L, MET80L, MET92K, PHE101L, PHE173K, PHE17K, PHE17L, PHE30K, PHE30L, PHE49L, PHE82L, PRO115K, PRO177K, PRO4K, PRO4L, PRO66K, SER117K, SER16K, SER16L, SER175K, SER21L, SER65K, SER75L, THR133L, THR190K, THR32K, THR71L, THR79L, TYR128L, TYR20K, TYR20L, TYR62K, TYR77L, VAL119K, VAL145L, VAL28K, VAL3K, VAL3L, VAL44L, VAL69L, VAL6K
• L-J: LEU2J, LEU42L
• L-N: LEU2L, LEU42N
• L-F: ARG170F, ARG170L, ASP171F, ASP171L, GLN123F, GLN123L, GLU169F, GLU169L, HIS122F, HIS122L, LYS146F, LYS146L, THR168F, THR168L
• L-E: ALA132E, ALA132L, ALA139E, ALA139L, ARG140E, ARG140L, ARG170E, ARG170L, ASN150E, ASN150L, ASP134E, ASP134L, ASP171E, ASP171L, GLN123E, GLN123L, GLN129E, GLN129L, GLN131E, GLN131L, GLU136E, GLU136L, GLU141E, GLU141L, GLU169E, GLU169L, GLY126E, GLY126L, GLY127E, GLY127L, GLY130E, GLY130L, GLY147E, GLY147L, HIS122E, HIS122L, HIS138E, HIS138L, ILE121E, ILE121L, ILE135E, ILE135L, ILE137E, ILE137L, ILE142E, ILE142L, ILE70E, ILE70L, LEU125E, LEU125L, LEU143E, LEU143L, LYS144E, LYS144L, LYS146E, LYS146L, MET120E, MET120L, PRO124E, PRO124L, THR133E, THR133L, THR168E, THR168L, TYR128E, TYR128L, VAL145E, VAL145L
• L-D: ASP134D, ASP134L, GLN131D, GLN131L, HIS138D, HIS138L, ILE137D, ILE137L, TYR128D, TYR128L
• L-k: ALA45L, ALA52L, ALA705k, ASP78L, GLN81L, GLU51L, ILE76L, ILE83L, LEU48L, LYS84L, MET47L, MET80L, PHE701k, PHE82L, PRO55L, PRO703k, SER702k, SER75L, THR79L, VAL44L
• L-l: ALA705l, ARG111L, ASP58L, CYS91L, HIS191L, ILE59L, ILE63L, ILE90L, LEU114L, LEU189L, LEU23L, LEU61L, LYS110L, MET92L, PHE112L, PHE30L, PHE701l, PRO115L, PRO703l, SER702l, SER88L, THR190L, THR89L, TYR60L, TYR62L, VAL28L
• K-J: ALA132K, ALA139K, ALA176J, ALA40K, ALA45K, ALA52K, ALA72K, ALA95J, ALA96J, ARG118J, ARG140K, ARG148K, ARG15J, ARG15K, ARG170J, ARG172J, ARG22J, ARG22K, ASN116J, ASN41K, ASN64J, ASP134K, ASP167J, ASP171J, ASP18J, ASP18K, ASP37K, ASP78K, CYS113J, CYS91J, GLN131K, GLN34J, GLN46K, GLN81K, GLN94J, GLN9J, GLU136K, GLU141K, GLU14J, GLU14K, GLU169J, GLU178J, GLU26J, GLU36K, GLU51K, GLU53K, GLU8J, GLU8K, GLY130K, GLY13K, GLY33J, GLY73K, GLY93J, HIS122J, HIS138K, HIS156K, HIS191J, HIS38K, ILE121J, ILE135K, ILE137K, ILE142K, ILE188J, ILE19J, ILE19K, ILE29J, ILE29K, ILE43K, ILE63J, ILE70K, ILE76K, ILE7J, ILE83K, ILE90J, LEU114J, LEU152K, LEU155K, LEU174J, LEU189J, LEU23J, LEU23K, LEU24K, LEU2J, LEU31J, LEU42K, LEU48K, LEU50K, LYS144K, LYS146K, LYS25K, LYS84K, MET120J, MET149K, MET39J, MET39K, MET47K, MET5J, MET5K, MET74K, MET80K, MET92J, PHE101K, PHE112J, PHE173J, PHE17J, PHE17K, PHE30J, PHE30K, PHE49K, PHE82K, PRO115J, PRO177J, PRO4J, PRO4K, PRO66J, SER117J, SER16J, SER16K, SER175J, SER21K, SER65J, SER75K, THR10K, THR133K, THR190J, THR32J, THR71K, THR79K, TYR128K, TYR20J, TYR20K, TYR62J, TYR77K, VAL119J, VAL145K, VAL28J, VAL3J, VAL3K, VAL44K, VAL69K, VAL6J
• K-E: ARG170E, ARG170K, ASP171E, ASP171K, GLN123E, GLN123K, GLU169E, GLU169K, HIS122E, HIS122K, LYS146E, LYS146K, THR168E, THR168K
• K-D: ALA132D, ALA132K, ALA139D, ALA139K, ARG140D, ARG140K, ARG170D, ARG170K, ASN150D, ASN150K, ASP134D, ASP134K, ASP171D, ASP171K, GLN123D, GLN123K, GLN129D, GLN129K, GLN131D, GLN131K, GLU136D, GLU136K, GLU141D, GLU141K, GLU169D, GLU169K, GLY126D, GLY126K, GLY127D, GLY127K, GLY130D, GLY130K, GLY147D, GLY147K, HIS122D, HIS122K, HIS138D, HIS138K, ILE121D, ILE121K, ILE135D, ILE135K, ILE137D, ILE137K, ILE142D, ILE142K, ILE70D, ILE70K, LEU125D, LEU125K, LEU143D, LEU143K, LYS144D, LYS144K, LYS146D, LYS146K, MET120D, MET120K, PRO124D, PRO124K, THR133D, THR133K, THR168D, THR168K, TYR128D, TYR128K, VAL145D, VAL145K
• K-C: ASP134C, ASP134K, GLN131C, GLN131K, HIS138C, ILE137C, TYR128C, TYR128K
• K-j: ALA45K, ALA52K, ALA705j, ASN41K, ASP78K, GLU51K, ILE76K, ILE83K, LEU48K, LYS84K, MET47K, MET80K, PHE701j, PHE82K, PRO55K, PRO703j, SER702j, SER75K, THR79K, VAL44K
• K-k: ALA705k, ARG111K, ASP58K, CYS91K, HIS191K, ILE59K, ILE63K, ILE90K, LEU114K, LEU189K, LEU61K, LYS110K, MET92K, PHE112K, PHE30K, PHE701k, PRO115K, PRO703k, SER702k, SER88K, THR190K, THR89K, TYR60K, TYR62K, VAL28K
• J-I: ALA132J, ALA139J, ALA176I, ALA40J, ALA45J, ALA52J, ALA72J, ALA95I, ALA96I, ARG118I, ARG12J, ARG140J, ARG148J, ARG15I, ARG15J, ARG170I, ARG172I, ARG22I, ARG22J, ASN116I, ASN41J, ASN64I, ASP134J, ASP171I, ASP18I, ASP18J, ASP37J, ASP78J, CYS113I, CYS91I, GLN131J, GLN34I, GLN46J, GLN81J, GLN94I, GLN9I, GLU136J, GLU141J, GLU14I, GLU14J, GLU169I, GLU178I, GLU26I, GLU36J, GLU51J, GLU53J, GLU8I, GLU8J, GLY130J, GLY13I, GLY13J, GLY33I, GLY73J, GLY93I, HIS122I, HIS138J, HIS156J, HIS191I, HIS38J, ILE121I, ILE135J, ILE137J, ILE142J, ILE188I, ILE19I, ILE19J, ILE29I, ILE29J, ILE43J, ILE63I, ILE70J, ILE76J, ILE7I, ILE83J, ILE90I, LEU114I, LEU125I, LEU152J, LEU155J, LEU174I, LEU189I, LEU23I, LEU24J, LEU2I, LEU31I, LEU42J, LEU48J, LEU50J, LYS144J, LYS146J, LYS25J, LYS84J, MET120I, MET149J, MET39I, MET39J, MET47J, MET5I, MET5J, MET74J, MET80J, MET92I, PHE101J, PHE173I, PHE17I, PHE17J, PHE30I, PHE30J, PHE49J, PHE82J, PRO115I, PRO177I, PRO4I, PRO4J, PRO66I, SER117I, SER16I, SER16J, SER175I, SER21J, SER65I, SER75J, THR10I, THR10J, THR133J, THR190I, THR32I, THR71J, THR79J, TYR128J, TYR20I, TYR20J, TYR62I, TYR77J, VAL119I, VAL145J, VAL28I, VAL3I, VAL3J, VAL44J, VAL69J, VAL6I
• J-H: LEU2H, LEU42J
• J-D: ARG170D, ARG170J, ASP171D, ASP171J, GLN123D, GLN123J, GLU169D, GLU169J, HIS122D, HIS122J, LYS146D, LYS146J, THR168D, THR168J
• J-C: ALA132C, ALA132J, ALA139C, ALA139J, ARG140C, ARG140J, ARG170C, ARG170J, ASN150C, ASN150J, ASP134C, ASP134J, ASP171C, ASP171J, GLN123C, GLN123J, GLN129C, GLN129J, GLN131C, GLN131J, GLU136C, GLU136J, GLU141C, GLU141J, GLU169C, GLU169J, GLY126C, GLY126J, GLY127C, GLY127J, GLY130C, GLY130J, GLY147C, GLY147J, HIS122C, HIS122J, HIS138C, HIS138J, ILE121C, ILE135C, ILE135J, ILE137C, ILE137J, ILE142C, ILE142J, ILE70C, ILE70J, LEU125C, LEU125J, LEU143C, LEU143J, LYS144C, LYS144J, LYS146C, LYS146J, PRO124C, PRO124J, THR133C, THR133J, THR168C, THR168J, TYR128C, TYR128J, VAL145C, VAL145J
• J-B: ASP134B, ASP134J, GLN131B, GLN131J, HIS138B, HIS138J, ILE137B, ILE137J, TYR128B, TYR128J
• J-i: ALA45J, ALA52J, ALA705i, ASN41J, ASP78J, GLN81J, GLU51J, ILE76J, ILE83J, LEU48J, LYS84J, MET47J, MET80J, PHE701i, PHE82J, PRO55J, PRO703i, SER702i, SER75J, THR79J, VAL44J
• J-j: ALA705j, ARG111J, ASP58J, CYS91J, GLU26J, GLY93J, HIS191J, ILE59J, ILE63J, ILE90J, LEU114J, LEU189J, LEU23J, LEU61J, LYS110J, MET92J, PHE112J, PHE30J, PHE701j, PRO115J, PRO703j, SER702j, SER88J, THR190J, THR89J, TYR60J, TYR62J, VAL28J
• I-H: ALA132I, ALA139I, ALA176H, ALA1H, ALA40I, ALA45I, ALA52I, ALA72I, ALA95H, ALA96H, ARG118H, ARG12I, ARG140I, ARG148I, ARG15I, ARG170H, ARG172H, ARG22H, ARG22I, ASN116H, ASN41I, ASN64H, ASP134I, ASP171H, ASP18H, ASP18I, ASP37I, ASP78I, CYS113H, CYS91H, GLN131I, GLN34H, GLN46I, GLN81I, GLN94H, GLU136I, GLU141I, GLU14H, GLU14I, GLU151I, GLU169H, GLU178H, GLU26H, GLU36I, GLU53I, GLU8H, GLU8I, GLY130I, GLY33H, GLY73I, GLY93H, HIS122H, HIS138I, HIS156I, HIS191H, HIS38I, ILE121H, ILE135I, ILE137I, ILE142I, ILE188H, ILE19H, ILE19I, ILE29H, ILE29I, ILE43I, ILE63H, ILE70I, ILE76I, ILE7H, ILE83I, ILE90H, LEU114H, LEU125H, LEU152I, LEU155I, LEU174H, LEU189H, LEU23H, LEU23I, LEU24I, LEU2H, LEU2I, LEU31H, LEU42I, LEU48I, LEU50I, LYS144I, LYS146I, LYS25I, LYS84I, MET120H, MET149I, MET39H, MET39I, MET47I, MET5H, MET5I, MET74I, MET80I, MET92H, PHE101I, PHE173H, PHE17H, PHE17I, PHE30H, PHE30I, PHE49I, PHE82I, PRO115H, PRO124I, PRO177H, PRO4H, PRO66H, SER117H, SER16H, SER16I, SER175H, SER21I, SER65H, SER75I, THR10I, THR133I, THR190H, THR32H, THR71I, THR79I, TYR128I, TYR20H, TYR20I, TYR62H, TYR77I, VAL119H, VAL145I, VAL28H, VAL3H, VAL3I, VAL44I, VAL69I, VAL6H
• I-N: LEU2N, LEU42I
• I-C: ARG170C, ARG170I, ASP171C, ASP171I, GLN123C, GLN123I, GLU169C, GLU169I, HIS122C, HIS122I, LYS146C, LYS146I, THR168C, THR168I
• I-B: ALA132B, ALA132I, ALA139B, ALA139I, ARG140B, ARG140I, ARG170B, ARG170I, ASN150B, ASN150I, ASP134B, ASP134I, ASP171B, ASP171I, GLN123B, GLN123I, GLN129B, GLN129I, GLN131B, GLN131I, GLU136B, GLU136I, GLU141B, GLU141I, GLU169B, GLU169I, GLY126B, GLY126I, GLY127B, GLY127I, GLY130B, GLY130I, GLY147B, GLY147I, HIS122B, HIS122I, HIS138B, HIS138I, ILE121B, ILE121I, ILE135B, ILE135I, ILE137B, ILE137I, ILE142B, ILE142I, ILE70B, ILE70I, LEU125B, LEU125I, LEU143B, LEU143I, LYS144B, LYS144I, LYS146B, LYS146I, MET120B, PRO124B, PRO124I, THR133B, THR133I, THR168B, THR168I, TYR128B, TYR128I, VAL145B, VAL145I
• I-A: ASP134A, ASP134I, GLN131A, GLN131I, HIS138A, HIS138I, ILE137A, ILE137I, TYR128A, TYR128I
• I-h: ALA45I, ALA52I, ALA705h, ASP78I, GLN81I, GLU51I, ILE76I, ILE83I, LEU48I, LYS84I, MET47I, MET80I, PHE701h, PHE82I, PRO55I, PRO703h, SER702h, SER75I, THR79I, VAL44I
• I-i: ALA705i, ARG111I, ASP58I, CYS91I, GLU26I, GLY93I, HIS191I, ILE59I, ILE63I, ILE90I, LEU114I, LEU189I, LEU23I, LEU61I, LYS110I, MET92I, PHE112I, PHE30I, PHE701i, PRO115I, PRO703i, SER702i, SER88I, THR190I, THR89I, TYR60I, TYR62I, VAL28I
• H-N: ALA132H, ALA139H, ALA176N, ALA1H, ALA40H, ALA45H, ALA52H, ALA72H, ALA95N, ALA96N, ARG118N, ARG140H, ARG148H, ARG15H, ARG15N, ARG170N, ARG172N, ARG22H, ARG22N, ASN116N, ASN41H, ASN64N, ASP134H, ASP171N, ASP18H, ASP18N, ASP37H, ASP78H, CYS113N, CYS91N, GLN131H, GLN34N, GLN46H, GLN81H, GLN94N, GLN9N, GLU136H, GLU141H, GLU14H, GLU14N, GLU151H, GLU169N, GLU178N, GLU26N, GLU36H, GLU51H, GLU53H, GLU8H, GLU8N, GLY130H, GLY33N, GLY73H, GLY93N, HIS122N, HIS138H, HIS156H, HIS191N, HIS38H, ILE121N, ILE135H, ILE137H, ILE142H, ILE188N, ILE19H, ILE19N, ILE29H, ILE29N, ILE43H, ILE63N, ILE70H, ILE76H, ILE7N, ILE83H, ILE90N, LEU114N, LEU125N, LEU152H, LEU174N, LEU189N, LEU23H, LEU23N, LEU24H, LEU2H, LEU2N, LEU31N, LEU42H, LEU48H, LEU50H, LYS144H, LYS146H, LYS25H, LYS84H, MET120N, MET149H, MET39H, MET39N, MET47H, MET5H, MET5N, MET74H, MET80H, MET92N, PHE101H, PHE112N, PHE173N, PHE17H, PHE17N, PHE30H, PHE30N, PHE49H, PHE82H, PRO115N, PRO124H, PRO177N, PRO4H, PRO4N, PRO66N, SER117N, SER16H, SER16N, SER175N, SER21H, SER65N, SER75H, THR133H, THR190N, THR32N, THR71H, THR79H, TYR128H, TYR20H, TYR20N, TYR62N, TYR77H, VAL119N, VAL145H, VAL28N, VAL3H, VAL3N, VAL44H, VAL69H, VAL6N
• H-B: ARG170B, ARG170H, ASP171B, ASP171H, GLN123B, GLN123H, GLU169B, GLU169H, HIS122B, HIS122H, LYS146B, LYS146H, THR168B, THR168H
• H-A: ALA132A, ALA132H, ALA139A, ALA139H, ARG140A, ARG140H, ARG170A, ARG170H, ASN150A, ASN150H, ASP134A, ASP134H, ASP171A, ASP171H, GLN123A, GLN123H, GLN129A, GLN129H, GLN131A, GLN131H, GLU136A, GLU136H, GLU141A, GLU141H, GLU169A, GLU169H, GLY126A, GLY126H, GLY127A, GLY127H, GLY130A, GLY130H, GLY147A, GLY147H, HIS122A, HIS122H, HIS138A, HIS138H, ILE121A, ILE121H, ILE135A, ILE135H, ILE137A, ILE137H, ILE142A, ILE142H, ILE70H, LEU125A, LEU125H, LEU143A, LEU143H, LYS144A, LYS144H, LYS146A, LYS146H, MET120A, PRO124A, PRO124H, THR133A, THR133H, THR168A, THR168H, TYR128A, TYR128H, VAL145A, VAL145H
• H-G: ASP134G, ASP134H, GLN131G, GLN131H, HIS138G, HIS138H, ILE137G, ILE137H, TYR128G, TYR128H
• H-h: ALA705h, ARG111H, ASP58H, CYS91H, GLU26H, GLY93H, HIS191H, ILE59H, ILE63H, ILE90H, LEU114H, LEU189H, LEU23H, LEU61H, LYS110H, MET92H, PHE112H, PHE30H, PHE701h, PRO115H, PRO703h, SER702h, SER88H, THR190H, THR89H, TYR60H, TYR62H, VAL28H
• H-n: ALA45H, ALA52H, ALA705n, ASP78H, GLN81H, GLU51H, ILE76H, ILE83H, LEU48H, LYS84H, MET47H, MET80H, PHE701n, PHE82H, PRO55H, PRO703n, SER702n, SER75H, THR79H, VAL44H
• H-s: SER160H, SER702s
• N-F: ASP134F, ASP134N, GLN131F, GLN131N, HIS138F, HIS138N, ILE137F, ILE137N, TYR128F, TYR128N
• N-A: ARG170A, ARG170N, ASP171A, ASP171N, GLN123A, GLN123N, GLU169A, GLU169N, HIS122A, HIS122N, LYS146A, LYS146N, THR168A, THR168N
• N-G: ALA132G, ALA132N, ALA139G, ALA139N, ARG140G, ARG140N, ARG170G, ARG170N, ASN150G, ASN150N, ASP134G, ASP134N, ASP171G, ASP171N, GLN123G, GLN123N, GLN129G, GLN129N, GLN131G, GLN131N, GLU136G, GLU136N, GLU141N, GLU169G, GLU169N, GLY126G, GLY126N, GLY127G, GLY127N, GLY130G, GLY130N, GLY147G, GLY147N, HIS122G, HIS122N, HIS138G, HIS138N, ILE121G, ILE121N, ILE135G, ILE135N, ILE137G, ILE137N, ILE142G, ILE142N, ILE70G, ILE70N, LEU125G, LEU125N, LEU143G, LEU143N, LYS144G, LYS144N, LYS146G, LYS146N, MET120G, MET120N, PRO124G, PRO124N, THR133G, THR133N, THR168G, THR168N, TYR128G, TYR128N, VAL145G, VAL145N
• N-m: ALA45N, ALA52N, ALA705m, ASN41N, ASP78N, GLN81N, GLU51N, ILE76N, ILE83N, LEU48N, LYS84N, MET47N, MET80N, PHE701m, PHE82N, PRO55N, PRO703m, SER702m, SER75N, THR79N, VAL44N
• N-n: ALA705n, ARG111N, ASP58N, CYS91N, GLU26N, HIS191N, ILE59N, ILE63N, ILE90N, LEU114N, LEU189N, LEU23N, LEU61N, LYS110N, MET92N, PHE112N, PHE30N, PHE701n, PRO115N, PRO703n, SER702n, SER88N, THR190N, THR89N, TYR60N, TYR62N, VAL28N
• F-E: ALA132E, ALA139E, ALA176F, ALA40E, ALA45E, ALA52E, ALA72E, ALA95F, ALA96F, ARG118F, ARG140E, ARG148E, ARG15E, ARG170F, ARG172F, ARG22E, ARG22F, ASN116F, ASN41E, ASN64F, ASP134E, ASP171F, ASP18E, ASP18F, ASP37E, ASP78E, CYS113F, CYS91F, GLN131E, GLN34F, GLN46E, GLN81E, GLN94F, GLN9F, GLU136E, GLU141E, GLU14E, GLU14F, GLU169F, GLU178F, GLU26F, GLU36E, GLU51E, GLU53E, GLU8E, GLU8F, GLY130E, GLY13E, GLY33F, GLY67F, GLY73E, GLY93F, HIS122F, HIS138E, HIS156E, HIS191F, HIS38E, ILE121F, ILE135E, ILE137E, ILE142E, ILE188F, ILE19E, ILE19F, ILE29E, ILE29F, ILE43E, ILE63F, ILE70E, ILE76E, ILE7F, ILE83E, ILE90F, LEU114F, LEU152E, LEU155E, LEU174F, LEU189F, LEU23E, LEU23F, LEU24E, LEU2F, LEU31F, LEU42E, LEU48E, LEU50E, LYS144E, LYS146E, LYS25E, LYS84E, MET120F, MET149E, MET39E, MET39F, MET47E, MET5E, MET5F, MET74E, MET80E, MET92F, PHE101E, PHE112F, PHE173F, PHE17E, PHE17F, PHE30E, PHE30F, PHE49E, PHE82E, PRO115F, PRO177F, PRO4F, PRO66F, SER117F, SER16E, SER16F, SER175F, SER21E, SER65F, SER75E, THR10E, THR133E, THR190F, THR32F, THR71E, THR79E, TYR128E, TYR20E, TYR20F, TYR62F, TYR77E, VAL119F, VAL145E, VAL28E, VAL28F, VAL3E, VAL3F, VAL44E, VAL69E, VAL6F
• F-D: LEU2F, LEU42D
• F-A: LEU2A, LEU42F
• F-G: ALA132F, ALA139F, ALA176G, ALA40F, ALA45F, ALA52F, ALA72F, ALA95G, ALA96G, ARG118G, ARG12F, ARG12G, ARG140F, ARG148F, ARG15F, ARG15G, ARG170G, ARG172G, ARG22F, ARG22G, ASN116G, ASN41F, ASN64G, ASP134F, ASP171G, ASP18F, ASP18G, ASP37F, ASP78F, CYS113G, CYS91G, GLN131F, GLN34G, GLN46F, GLN81F, GLN94G, GLN9G, GLU136F, GLU141F, GLU14F, GLU14G, GLU151F, GLU169G, GLU178G, GLU26G, GLU36F, GLU51F, GLU53F, GLU8F, GLU8G, GLY130F, GLY13F, GLY13G, GLY33G, GLY73F, GLY93G, HIS122G, HIS138F, HIS156F, HIS191G, HIS38F, ILE121G, ILE135F, ILE137F, ILE142F, ILE188G, ILE19F, ILE19G, ILE29F, ILE29G, ILE43F, ILE63G, ILE70F, ILE76F, ILE7G, ILE83F, ILE90G, LEU114G, LEU152F, LEU174G, LEU189G, LEU23G, LEU24F, LEU2F, LEU2G, LEU31G, LEU42F, LEU48F, LEU50F, LYS144F, LYS146F, LYS25F, LYS84F, MET120G, MET149F, MET39F, MET39G, MET47F, MET5F, MET5G, MET74F, MET80F, MET92G, PHE101F, PHE173G, PHE17F, PHE17G, PHE30F, PHE30G, PHE49F, PHE82F, PRO115G, PRO124F, PRO177G, PRO4F, PRO4G, PRO66G, SER117G, SER11F, SER11G, SER16F, SER16G, SER175G, SER21F, SER65G, SER75F, THR10F, THR10G, THR133F, THR190G, THR32G, THR71F, THR79F, TYR128F, TYR20F, TYR20G, TYR62G, TYR77F, VAL119G, VAL145F, VAL28G, VAL3F, VAL3G, VAL44F, VAL69F, VAL6G
• F-f: ALA705f, ARG111F, ASP58F, CYS91F, GLU26F, GLY93F, HIS191F, ILE59F, ILE63F, ILE90F, LEU114F, LEU189F, LEU23F, LEU61F, LYS110F, MET92F, PHE112F, PHE30F, PHE701f, PRO115F, PRO703f, SER702f, SER88F, THR190F, THR89F, TYR60F, TYR62F, VAL28F
• F-g: ALA45F, ALA52F, ALA705g, ASP78F, GLN81F, GLU51F, ILE76F, ILE83F, LEU48F, LYS84F, MET47F, MET80F, PHE701g, PHE82F, PRO55F, PRO703g, SER702g, SER75F, THR79F, VAL44F
• E-D: ALA132D, ALA139D, ALA176E, ALA40D, ALA45D, ALA52D, ALA72D, ALA95E, ALA96E, ARG118E, ARG140D, ARG148D, ARG15D, ARG15E, ARG170E, ARG172E, ARG22D, ARG22E, ASN116E, ASN41D, ASN64E, ASP134D, ASP171E, ASP18D, ASP18E, ASP37D, ASP78D, ASP86D, CYS113E, CYS91E, GLN131D, GLN34E, GLN46D, GLN81D, GLN94E, GLN9E, GLU136D, GLU141D, GLU14D, GLU14E, GLU151D, GLU169E, GLU178E, GLU26E, GLU36D, GLU51D, GLU53D, GLU8D, GLU8E, GLY130D, GLY13D, GLY33E, GLY73D, GLY93E, HIS122E, HIS138D, HIS156D, HIS191E, HIS38D, ILE121E, ILE135D, ILE137D, ILE142D, ILE188E, ILE19D, ILE19E, ILE29D, ILE43D, ILE63E, ILE70D, ILE76D, ILE7E, ILE83D, ILE90E, LEU114E, LEU152D, LEU174E, LEU189E, LEU23E, LEU24D, LEU2E, LEU31E, LEU42D, LEU48D, LEU50D, LYS144D, LYS146D, LYS25D, LYS84D, MET120E, MET149D, MET39D, MET39E, MET47D, MET5D, MET5E, MET74D, MET80D, MET92E, PHE101D, PHE112E, PHE173E, PHE17D, PHE17E, PHE30D, PHE30E, PHE49D, PHE82D, PRO115E, PRO124D, PRO177E, PRO4D, PRO4E, PRO66E, PRO85D, SER117E, SER16D, SER16E, SER175E, SER21D, SER65E, SER75D, THR10D, THR133D, THR190E, THR32E, THR71D, THR79D, TYR128D, TYR20D, TYR20E, TYR62E, TYR77D, VAL119E, VAL145D, VAL28E, VAL3D, VAL3E, VAL44D, VAL69D, VAL6E
• E-C: LEU2E, LEU42C
• E-G: HIS38E, LEU2G, LEU42E
• E-e: ALA705e, ARG111E, ASP58E, CYS91E, GLU26E, GLY93E, HIS191E, ILE59E, ILE63E, ILE90E, LEU114E, LEU189E, LEU23E, LEU61E, LYS110E, MET92E, PHE112E, PHE30E, PHE701e, PRO115E, PRO703e, SER702e, SER88E, THR190E, THR89E, TYR60E, TYR62E, VAL28E
• E-f: ALA45E, ALA52E, ALA705f, ASP78E, GLN81E, GLU51E, ILE76E, ILE83E, LEU48E, LYS84E, MET47E, MET80E, PHE701f, PHE82E, PRO55E, PRO703f, SER702f, SER75E, THR79E, VAL44E
• D-C: ALA132C, ALA139C, ALA176D, ALA40C, ALA45C, ALA52C, ALA72C, ALA95D, ALA96D, ARG118D, ARG140C, ARG148C, ARG15C, ARG15D, ARG170D, ARG172D, ARG22C, ARG22D, ASN116D, ASN41C, ASN64D, ASP134C, ASP171D, ASP18C, ASP18D, ASP37C, ASP78C, CYS113D, CYS91D, GLN123D, GLN131C, GLN34D, GLN46C, GLN81C, GLN94D, GLN9D, GLU136C, GLU141C, GLU14C, GLU14D, GLU151C, GLU169D, GLU178D, GLU26D, GLU36C, GLU51C, GLU53C, GLU8C, GLU8D, GLY130C, GLY13C, GLY13D, GLY33D, GLY73C, GLY93D, HIS122D, HIS138C, HIS156C, HIS191D, HIS38C, ILE121D, ILE135C, ILE137C, ILE142C, ILE188D, ILE19C, ILE19D, ILE29C, ILE29D, ILE43C, ILE63D, ILE70C, ILE76C, ILE7D, ILE83C, ILE90D, LEU114D, LEU152C, LEU174D, LEU189D, LEU23C, LEU23D, LEU24C, LEU2D, LEU31D, LEU42C, LEU48C, LEU50C, LYS144C, LYS146C, LYS25C, LYS84C, MET120D, MET149C, MET39C, MET39D, MET47C, MET5C, MET5D, MET74C, MET80C, MET92D, PHE101C, PHE173D, PHE17C, PHE17D, PHE30C, PHE30D, PHE49C, PHE82C, PRO115D, PRO177D, PRO4C, PRO4D, PRO66D, SER117D, SER16C, SER16D, SER175D, SER21C, SER65D, SER75C, THR10C, THR133C, THR190D, THR32D, THR71C, THR79C, TYR128C, TYR20C, TYR20D, TYR62D, TYR77C, VAL119D, VAL145C, VAL28D, VAL3C, VAL3D, VAL44C, VAL69C, VAL6D
• D-B: LEU2D, LEU42B
• D-d: ALA705d, ARG111D, ASP58D, CYS91D, GLU26D, HIS191D, ILE59D, ILE63D, ILE90D, LEU114D, LEU189D, LEU23D, LEU61D, LYS110D, MET92D, PHE112D, PHE30D, PHE701d, PRO115D, PRO703d, SER702d, SER88D, THR190D, THR89D, TYR60D, TYR62D, VAL28D
• D-e: ALA45D, ALA52D, ALA705e, ASN41D, ASP78D, GLN81D, GLU51D, ILE76D, ILE83D, LEU48D, LYS84D, MET47D, MET80D, PHE701e, PHE82D, PRO55D, PRO703e, SER702e, SER75D, THR79D, VAL44D
• C-B: ALA132B, ALA139B, ALA176C, ALA1B, ALA40B, ALA45B, ALA52B, ALA72B, ALA95C, ALA96C, ARG118C, ARG140B, ARG148B, ARG15B, ARG15C, ARG170C, ARG172C, ARG22B, ARG22C, ASN116C, ASN41B, ASN64C, ASP134B, ASP171C, ASP18B, ASP18C, ASP37B, ASP78B, CYS113C, CYS91C, GLN131B, GLN34C, GLN46B, GLN81B, GLN94C, GLN9C, GLU136B, GLU141B, GLU14B, GLU14C, GLU169C, GLU178C, GLU26C, GLU36B, GLU51B, GLU53B, GLU8B, GLU8C, GLY130B, GLY33C, GLY73B, GLY93C, HIS122C, HIS138B, HIS156B, HIS191C, HIS38B, ILE121C, ILE135B, ILE137B, ILE142B, ILE188C, ILE19B, ILE19C, ILE29B, ILE29C, ILE43B, ILE63C, ILE70B, ILE76B, ILE7C, ILE83B, ILE90C, LEU114C, LEU152B, LEU155B, LEU174C, LEU189C, LEU23B, LEU23C, LEU24B, LEU2B, LEU2C, LEU31C, LEU42B, LEU48B, LEU50B, LYS144B, LYS146B, LYS25B, LYS84B, MET120C, MET149B, MET39B, MET39C, MET47B, MET5B, MET5C, MET74B, MET80B, MET92C, PHE101B, PHE173C, PHE17B, PHE17C, PHE30B, PHE30C, PHE49B, PHE82B, PRO115C, PRO124B, PRO177C, PRO4B, PRO4C, PRO66C, SER117C, SER16B, SER16C, SER175C, SER21B, SER65C, SER75B, THR10B, THR133B, THR190C, THR32C, THR71B, THR79B, TYR128B, TYR20B, TYR20C, TYR62C, TYR77B, VAL119C, VAL145B, VAL28C, VAL3B, VAL3C, VAL44B, VAL69B, VAL6C
• C-A: LEU2C, LEU42A
• C-c: ALA705c, ARG111C, ASP58C, CYS91C, GLU26C, HIS191C, ILE59C, ILE63C, ILE90C, LEU114C, LEU189C, LEU61C, LYS110C, MET92C, PHE112C, PHE30C, PHE701c, PRO115C, PRO703c, SER702c, SER88C, THR190C, THR89C, TYR60C, TYR62C, VAL28C
• C-d: ALA45C, ALA52C, ALA705d, ASN41C, ASP78C, GLU51C, ILE76C, ILE83C, LEU48C, LYS84C, MET47C, MET80C, PHE701d, PHE82C, PRO55C, PRO703d, SER702d, SER75C, THR79C, VAL44C
• B-A: ALA132A, ALA139A, ALA176B, ALA1B, ALA40A, ALA45A, ALA52A, ALA72A, ALA95B, ALA96B, ARG118B, ARG12A, ARG140A, ARG148A, ARG15A, ARG15B, ARG170B, ARG172B, ARG22A, ARG22B, ASN116B, ASN41A, ASN64B, ASP134A, ASP171B, ASP18A, ASP18B, ASP37A, ASP78A, CYS113B, CYS91B, GLN131A, GLN34B, GLN46A, GLN81A, GLN94B, GLN9B, GLU136A, GLU141A, GLU14B, GLU169B, GLU178B, GLU26B, GLU36A, GLU51A, GLU53A, GLU8A, GLU8B, GLY130A, GLY13A, GLY33B, GLY67B, GLY73A, GLY93B, HIS122B, HIS138A, HIS156A, HIS191B, HIS38A, ILE121B, ILE135A, ILE137A, ILE142A, ILE188B, ILE19A, ILE19B, ILE29A, ILE29B, ILE43A, ILE63B, ILE70A, ILE76A, ILE7B, ILE83A, ILE90B, LEU114B, LEU125B, LEU152A, LEU155A, LEU174B, LEU189B, LEU23A, LEU23B, LEU24A, LEU2A, LEU2B, LEU31B, LEU42A, LEU48A, LEU50A, LYS144A, LYS146A, LYS25A, LYS84A, MET120B, MET149A, MET39A, MET39B, MET47A, MET5A, MET5B, MET74A, MET80A, MET92B, PHE101A, PHE173B, PHE17A, PHE17B, PHE30A, PHE30B, PHE49A, PHE82A, PRO115B, PRO177B, PRO4A, PRO4B, PRO66B, SER117B, SER11A, SER16A, SER16B, SER175B, SER21A, SER65B, SER75A, THR10A, THR10B, THR133A, THR190B, THR32B, THR71A, THR79A, TYR128A, TYR20A, TYR20B, TYR62B, TYR77A, VAL119B, VAL145A, VAL28B, VAL3A, VAL3B, VAL44A, VAL69A, VAL6B
• B-G: LEU2B, LEU42G
• B-2: ALA7052, ARG111B, ASP58B, CYS91B, GLY93B, HIS191B, ILE59B, ILE63B, ILE90B, LEU114B, LEU189B, LEU23B, LEU61B, LYS110B, MET92B, PHE112B, PHE30B, PHE7012, PRO115B, PRO7032, SER7022, SER88B, THR190B, THR89B, TYR60B, TYR62B, VAL28B
• B-c: ALA45B, ALA52B, ALA705c, ASN41B, ASP78B, GLN81B, GLU51B, ILE76B, ILE83B, LEU48B, LYS84B, MET47B, MET80B, PHE701c, PHE82B, PRO55B, PRO703c, SER702c, SER75B, THR79B, VAL44B
• B-r: GLN163B, GLU162B, LEU161B, PRO703r, SER160B, SER702r
• A-G: ALA132G, ALA139G, ALA176A, ALA40G, ALA45G, ALA52G, ALA72G, ALA95A, ALA96A, ARG118A, ARG12A, ARG12G, ARG140G, ARG148G, ARG15A, ARG15G, ARG170A, ARG172A, ARG192A, ARG22A, ARG22G, ASN116A, ASN193A, ASN41G, ASN54G, ASN64A, ASP134G, ASP171A, ASP18A, ASP18G, ASP37G, ASP78G, ASP86G, CYS113A, CYS91A, GLN131G, GLN34A, GLN46G, GLN81G, GLN94A, GLN9A, GLU141G, GLU14A, GLU14G, GLU151G, GLU169A, GLU178A, GLU26A, GLU36G, GLU51G, GLU53G, GLU56G, GLU8A, GLU8G, GLY130G, GLY13A, GLY13G, GLY33A, GLY73G, GLY93A, HIS122A, HIS138G, HIS156G, HIS191A, HIS38G, ILE135G, ILE137G, ILE142G, ILE188A, ILE19A, ILE19G, ILE29A, ILE29G, ILE43G, ILE63A, ILE70G, ILE76G, ILE7A, ILE83G, ILE90A, LEU114A, LEU152G, LEU155G, LEU174A, LEU189A, LEU23A, LEU24G, LEU2A, LEU2G, LEU31A, LEU42G, LEU48G, LEU50G, LYS144G, LYS146G, LYS25G, LYS84G, MET120A, MET149G, MET39A, MET39G, MET47G, MET5A, MET5G, MET74G, MET80G, MET92A, PHE101G, PHE112A, PHE173A, PHE17A, PHE17G, PHE30A, PHE30G, PHE49G, PHE82G, PRO115A, PRO177A, PRO4A, PRO4G, PRO55G, PRO66A, PRO85G, SER117A, SER16A, SER16G, SER175A, SER21G, SER65A, SER75G, THR10A, THR10G, THR133G, THR190A, THR32A, THR71G, THR79G, TYR128G, TYR20A, TYR20G, TYR62A, TYR77G, VAL119A, VAL145G, VAL28A, VAL3A, VAL3G, VAL44G, VAL69G, VAL6A
• A-1: ALA7051, ARG111A, ARG192A, ASN193A, ASP58A, CYS91A, GLU26A, HIS191A, ILE59A, ILE63A, ILE90A, LEU114A, LEU189A, LEU23A, LEU61A, LYS110A, MET92A, PHE112A, PHE30A, PHE7011, PRO115A, PRO7031, SER7021, SER88A, THR190A, THR89A, TYR60A, TYR62A, VAL28A
• A-2: ALA45A, ALA52A, ALA7052, ASN41A, ASP78A, GLN81A, GLU51A, ILE76A, ILE83A, LEU48A, LYS84A, MET47A, MET80A, PHE7012, PHE82A, PRO55A, PRO7032, SER7022, SER75A, THR79A, VAL44A
• G-1: ALA45G, ALA52G, ALA7051, ASN41G, ASP78G, GLN81G, GLU51G, ILE76G, ILE83G, LEU48G, LYS84G, MET47G, MET80G, PHE7011, PHE82G, PRO55G, PRO7031, SER7021, SER75G, THR79G, TYR77G, VAL44G
• G-g: ALA705g, ARG111G, ASP58G, CYS91G, GLY93G, HIS191G, ILE59G, ILE63G, ILE90G, LEU114G, LEU189G, LEU23G, LEU61G, LYS110G, MET92G, PHE112G, PHE30G, PHE701g, PRO115G, PRO703g, SER702g, SER88G, THR190G, THR89G, TYR60G, TYR62G, VAL28G