3MQT

crystal structure of a mandelate racemase/muconate lactonizing enzyme from shewanella pealeana

• Total interactions analyzed: 276
• Total true interactions: 59
• Strongest Interaction:
  • Chains: A-C
  • Int. Res.: 107
  • Norm. En. per Res.: -5.9712
• Hub Node: C(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-22.1219	-20.1547	-135.833	-178.1095	68	15	0	5247	3	39	35
A-C	-107.0034	-312.3736	-219.543	-638.9201	107	19	5	9464	24	49	52
A-D	-21.8903	-73.1318	-336.146	-431.1681	163	5	4	14533	4	78	72
A-F	-21.4961	-41.018	-130.715	-193.2291	71	12	0	5274	3	40	38
B-D	-82.5717	-277.0025	-236.858	-596.4322	110	15	5	9466	24	50	51
B-E	-27.9546	-20.5345	-129.518	-178.0071	67	13	0	5172	3	39	33
B-G	-7.108	-76.1621	-337.358	-420.6281	161	7	4	14486	4	77	72
C-D	-18.3668	-28.6041	-124.808	-171.7789	69	11	0	5248	2	39	36
C-F	-14.9465	-72.1777	-347.354	-434.4782	164	6	4	14842	4	78	73
C-H	-13.3493	-17.6427	-122.633	-153.625	68	12	0	5247	3	39	34
C-K	0.0	0.0	-0.0102	-0.0102	6	0	0	9	0	2	5
C-L	0.0	35.1595	-19.07	16.0895	26	0	0	1053	0	16	25
D-G	-19.4456	-28.8945	-140.102	-188.4421	68	13	0	5287	3	39	32
D-K	0.0	35.4787	-21.2901	14.1886	29	0	0	1069	0	15	25
E-F	-19.4662	-26.101	-118.632	-164.1992	69	14	0	5148	3	39	34
E-G	-86.6042	-291.8385	-222.148	-600.5907	107	17	5	9324	24	48	51
E-H	-2.3885	-67.7049	-355.139	-425.2324	165	4	4	15118	4	77	75
F-H	-85.2628	-285.8145	-238.406	-609.4833	111	17	5	9455	22	49	51
G-H	-17.2772	-34.9079	-114.594	-166.7791	68	12	0	5145	3	39	34
G-V	0.0	34.6782			6
H-L	0.0	0.0	-0.0037	-0.0037	4	0	0	6	0	2	6
H-W	0.0	36.0382			6
I-J	-16.6124	-26.8719	-131.708	-175.1923	67	10	0	5096	3	37	32
I-K	-70.5777	-272.7458	-238.328	-581.6516	109	12	5	9419	21	48	51
I-L	-4.2082	-80.3794	-342.288	-426.8755	162	7	4	14827	4	78	72
I-N	-13.1236	-25.4245	-136.282	-174.8301	69	10	0	5081	3	40	30
I-Q	-3.3003	12.1227	-32.2923	-23.4699	39	0	1	1978	1	27	35
J-L	-85.8837	-280.6857	-239.438	-606.0074	111	18	5	9478	24	49	51
J-M	-7.1096	-26.4865	-131.246	-164.8421	69	14	0	5018	3	38	34
J-S	-4.1581	16.8083			10
J-W	0.0	-82.0242			22
K-L	-9.8435	-19.631	-136.839	-166.3135	68	13	0	5252	3	39	34
K-N	-17.2628	-71.6325	-321.21	-410.1053	159	5	4	14355	4	77	74
K-V	-16.7548	-26.3598			16
L-W	-15.6346	-29.1372			14
M-N	-19.4234	-23.5488	-133.815	-176.7872	70	13	0	5134	2	37	32
M-V	-2.4844	-70.0061			24
M-W	-76.8774	-260.6493			27
M-X	0.0	15.1612			12
N-Q	0.0	0.0	-0.0644	-0.0644	11	0	0	19	0	7	9
N-R	0.0	26.5504			11
N-V	-51.9488	-230.3187			24
O-P	-20.1716	-22.2069	-133.898	-176.2765	67	10	0	5186	2	38	32
O-Q	-62.7822	-272.3716	-232.894	-568.0478	112	23	5	9523	23	48	50
O-S	0.0	-77.3517			24
O-U	-14.9382	-25.794			13
P-S	-77.465	-259.9201			25
P-T	-22.9187	-16.1813			13
P-X	-4.893	-81.833			22
Q-R	-13.8359	-18.8579			14
Q-S	-21.6697	-22.7031			13
Q-U	-19.5061	-82.9297			24
R-T	-24.0232	-73.8321			24
R-U	-73.837	-286.505			25
R-X	-13.994	-24.2977			14
S-X	-6.4057	-17.8422			13
T-U	-17.0744	-24.9532			14
T-X	-92.2305	-265.4345			29
V-W	-15.7925	-14.8308			13

Interface residues

• A-B: ALA217A, ALA248B, ALA249B, ALA250A, ALA250B, ALA304B, ARG194B, ARG218A, ARG222A, ARG254B, ASN252B, ASN303B, ASP183A, ASP200B, ASP202B, ASP213A, ASP226B, ASP228B, ASP239A, ASP240A, CYS299B, GLN215A, GLN223A, GLN237A, GLN245A, GLN305B, GLU225B, GLU269A, GLU272B, GLU300B, GLU331B, GLY243A, GLY275B, HIS244A, HIS301B, HIS302B, HIS328B, ILE242A, ILE251B, ILE276B, ILE298B, ILE329B, LEU229B, LEU236A, LEU241A, LEU247A, LEU255B, LEU271B, LYS184A, LYS216A, LYS246A, LYS273A, MET307B, PHE231B, SER182A, SER277B, SER330B, THR212A, THR220A, THR253B, THR274B, TRP199B, TRP211A, TRP214A, TRP219A, TYR230B, TYR332B, VAL278B
• A-C: ALA113A, ALA121A, ALA121C, ALA128A, ALA128C, ALA5A, ALA5C, ALA80A, ALA80C, ARG264A, ARG264C, ARG294A, ARG294C, ARG73A, ARG73C, ARG79A, ARG79C, ARG84A, ARG84C, ASN6A, ASN6C, ASN81A, ASN81C, ASN83A, ASN83C, ASP297A, ASP297C, ASP74A, ASP74C, ASP87A, ASP87C, CYS327A, CYS327C, GLN116A, GLN116C, GLN129A, GLN129C, GLN268A, GLN268C, GLU269A, GLU269C, GLU272A, GLU272C, GLU300A, GLU300C, GLU77A, GLU77C, GLY114A, GLY114C, GLY118A, GLY118C, GLY126A, GLY126C, GLY127A, GLY127C, HIS301A, HIS301C, HIS302A, HIS302C, HIS328A, HIS328C, ILE295A, ILE295C, ILE298A, ILE298C, ILE325A, ILE325C, ILE329A, ILE329C, LEU117A, LEU117C, LEU124A, LEU124C, LEU292A, LEU292C, LEU293A, LEU293C, LEU76A, LEU76C, LYS123A, LYS123C, LYS130A, LYS130C, MET125A, MET125C, MET296A, MET296C, PHE265A, PHE265C, PHE323C, PHE78A, PHE78C, PRO120A, PRO120C, PRO75A, PRO75C, THR290A, THR290C, TYR110C, TYR122A, TYR122C, TYR82A, TYR82C, VAL119A, VAL119C, VAL326A, VAL326C
• A-D: ALA234A, ALA234D, ALA258A, ALA258D, ALA52A, ALA52D, ARG210A, ARG210D, ARG264A, ARG264D, ARG285A, ARG285D, ARG95A, ARG95D, ASN16A, ASN16D, ASN178A, ASN178D, ASN25A, ASN25D, ASN284A, ASN284D, ASN310A, ASN310D, ASN58A, ASN58D, ASN64A, ASN64D, ASN65A, ASN65D, ASP179A, ASP179D, ASP206A, ASP206D, ASP239A, ASP239D, ASP240A, ASP240D, ASP282A, ASP282D, ASP44A, ASP44D, ASP87A, ASP87D, CYS207A, CYS207D, CYS49A, CYS49D, GLN237A, GLN237D, GLN268A, GLN268D, GLU233A, GLU233D, GLU24A, GLU24D, GLU259A, GLU259D, GLU266A, GLU266D, GLU269A, GLU269D, GLU272A, GLU272D, GLU48A, GLU48D, GLU55A, GLU55D, GLU57A, GLU57D, GLU59A, GLU59D, GLY45A, GLY45D, GLY93A, GLY93D, GLY96A, GLY96D, GLY98A, GLY98D, HIS238A, HIS238D, HIS309A, HIS309D, HIS60A, HIS60D, ILE175A, ILE175D, ILE176A, ILE176D, ILE242A, ILE242D, ILE56A, ILE56D, ILE92A, ILE92D, LEU208A, LEU208D, LEU236A, LEU236D, LEU241A, LEU241D, LEU63A, LEU63D, LEU97A, LEU97D, LEU99A, LEU99D, LYS273A, LYS273D, LYS312A, LYS312D, LYS51A, LYS51D, LYS61A, LYS61D, LYS90A, LYS90D, MET260A, MET260D, MET50A, MET50D, MET94A, MET94D, PHE100A, PHE100D, PHE265A, PHE265D, PHE53A, PHE53D, PRO177A, PRO177D, PRO46A, PRO46D, PRO47A, PRO47D, SER261A, SER261D, SER54A, SER54D, THR212A, THR212D, THR262A, THR262D, THR263A, THR263D, THR26A, THR26D, THR89D, TRP270A, TRP270D, TRP311A, TRP311D, TRP62A, TRP62D, TRP91A, TRP91D, TYR140A, TYR140D, TYR209A, TYR209D, TYR86A, TYR86D
• A-F: ALA131A, ALA217F, ALA248A, ALA249A, ALA250A, ALA250F, ALA304A, ARG194A, ARG218F, ARG222F, ARG254A, ASN252A, ASN303A, ASP179F, ASP183F, ASP200A, ASP202A, ASP213F, ASP226A, ASP228A, ASP239F, ASP240F, CYS299A, GLN215F, GLN223F, GLN237F, GLN245F, GLN305A, GLU225A, GLU269F, GLU272A, GLU300A, GLU331A, GLY243F, GLY275A, HIS244F, HIS301A, HIS302A, HIS328A, ILE242F, ILE251A, ILE276A, ILE298A, ILE329A, LEU229A, LEU236F, LEU241F, LEU247F, LEU255A, LEU271A, LYS130A, LYS184F, LYS216F, LYS246F, LYS273F, MET307A, PHE231A, SER182F, SER277A, SER330A, THR212F, THR220F, THR253A, THR274A, TRP199A, TRP211F, TRP214F, TRP219F, TYR230A, TYR332A, VAL278A
• B-D: ALA113B, ALA113D, ALA121B, ALA121D, ALA128B, ALA128D, ALA5B, ALA5D, ALA80B, ALA80D, ARG264B, ARG264D, ARG294B, ARG294D, ARG73B, ARG73D, ARG79B, ARG79D, ARG84B, ARG84D, ASN6B, ASN6D, ASN81B, ASN81D, ASN83B, ASN83D, ASP297B, ASP297D, ASP74B, ASP74D, ASP87B, ASP87D, CYS299B, CYS327B, CYS327D, GLN116B, GLN116D, GLN129B, GLN129D, GLN268B, GLN268D, GLU269B, GLU269D, GLU272B, GLU272D, GLU300B, GLU300D, GLU77B, GLU77D, GLY114B, GLY114D, GLY118B, GLY118D, GLY126B, GLY126D, GLY127B, GLY127D, HIS301B, HIS301D, HIS302B, HIS302D, HIS328B, HIS328D, ILE295B, ILE295D, ILE298B, ILE298D, ILE325B, ILE325D, ILE329B, ILE329D, LEU117B, LEU117D, LEU124B, LEU124D, LEU292B, LEU292D, LEU293B, LEU293D, LEU76B, LEU76D, LYS123B, LYS123D, LYS130B, LYS130D, MET125B, MET125D, MET296B, MET296D, PHE265B, PHE265D, PHE323B, PHE78B, PHE78D, PRO120B, PRO120D, PRO75B, PRO75D, THR290B, THR290D, TYR110D, TYR122B, TYR122D, TYR82B, TYR82D, TYR86B, VAL119B, VAL119D, VAL326B, VAL326D
• B-E: ALA217B, ALA248E, ALA249E, ALA250B, ALA250E, ALA304E, ARG194E, ARG218B, ARG222B, ARG254E, ASN252E, ASN303E, ASP183B, ASP202E, ASP213B, ASP226E, ASP228E, ASP239B, ASP240B, CYS299E, GLN215B, GLN223B, GLN237B, GLN245B, GLN305E, GLU225E, GLU269B, GLU272E, GLU300E, GLU331E, GLY243B, GLY275E, HIS244B, HIS301E, HIS302E, HIS328E, ILE232E, ILE242B, ILE251E, ILE276E, ILE298E, ILE329E, LEU229E, LEU236B, LEU241B, LEU247B, LEU255E, LEU271E, LYS184B, LYS216B, LYS246B, LYS273B, MET307E, PHE231E, SER277E, SER330E, THR212B, THR220B, THR253E, THR274E, TRP199E, TRP211B, TRP214B, TRP219B, TYR230E, TYR332E, VAL278E
• B-G: ALA234B, ALA234G, ALA258B, ALA258G, ALA52B, ALA52G, ARG210B, ARG210G, ARG264B, ARG264G, ARG285B, ARG285G, ARG95B, ARG95G, ASN16B, ASN16G, ASN178B, ASN178G, ASN25B, ASN25G, ASN284B, ASN284G, ASN310B, ASN310G, ASN58B, ASN58G, ASN64B, ASN64G, ASN65B, ASN65G, ASP179B, ASP179G, ASP206B, ASP206G, ASP239B, ASP239G, ASP240B, ASP240G, ASP282B, ASP282G, ASP44B, ASP44G, ASP87B, ASP87G, CYS207B, CYS207G, CYS49B, CYS49G, GLN237B, GLN237G, GLN268B, GLN268G, GLU233G, GLU24B, GLU24G, GLU259B, GLU259G, GLU266B, GLU266G, GLU269B, GLU269G, GLU272B, GLU272G, GLU48B, GLU48G, GLU55B, GLU55G, GLU57B, GLU57G, GLU59B, GLU59G, GLY45B, GLY45G, GLY93B, GLY93G, GLY96B, GLY96G, GLY98B, GLY98G, HIS238B, HIS238G, HIS309B, HIS309G, HIS60B, HIS60G, ILE175B, ILE175G, ILE176B, ILE176G, ILE242B, ILE242G, ILE56B, ILE56G, ILE92B, ILE92G, LEU208B, LEU208G, LEU236B, LEU236G, LEU241B, LEU241G, LEU63B, LEU63G, LEU97B, LEU97G, LEU99B, LEU99G, LYS273B, LYS273G, LYS312B, LYS312G, LYS51B, LYS51G, LYS61B, LYS61G, LYS90B, LYS90G, MET260B, MET260G, MET50B, MET50G, MET94B, MET94G, PHE100B, PHE100G, PHE265B, PHE265G, PHE53B, PHE53G, PRO177B, PRO177G, PRO46B, PRO46G, PRO47B, PRO47G, SER261B, SER261G, SER54B, SER54G, THR212B, THR212G, THR262B, THR262G, THR263B, THR263G, THR26G, THR89B, THR89G, TRP270B, TRP270G, TRP311B, TRP311G, TRP62B, TRP62G, TRP91B, TRP91G, TYR140G, TYR209B, TYR209G, TYR86B, TYR86G
• C-D: ALA131C, ALA217D, ALA248C, ALA249C, ALA250C, ALA250D, ALA304C, ARG194C, ARG218D, ARG222D, ARG254C, ASN252C, ASN303C, ASP179D, ASP183D, ASP200C, ASP202C, ASP213D, ASP228C, ASP239D, ASP240D, CYS299C, GLN215D, GLN223D, GLN237D, GLN245D, GLN305C, GLU225C, GLU269D, GLU272C, GLU300C, GLU331C, GLY243D, GLY275C, HIS244D, HIS301C, HIS302C, HIS328C, ILE232C, ILE242D, ILE251C, ILE276C, ILE298C, ILE329C, LEU229C, LEU236D, LEU241D, LEU247D, LEU255C, LEU271C, LYS184D, LYS216D, LYS246D, LYS273D, MET307C, PHE231C, SER277C, SER330C, THR212D, THR220D, THR253C, THR274C, TRP199C, TRP211D, TRP214D, TRP219D, TYR230C, TYR332C, VAL278C
• C-F: ALA234C, ALA234F, ALA258C, ALA258F, ALA52C, ALA52F, ARG210C, ARG210F, ARG264C, ARG264F, ARG285C, ARG285F, ARG95C, ARG95F, ASN16C, ASN16F, ASN178C, ASN178F, ASN25C, ASN25F, ASN284C, ASN284F, ASN310C, ASN310F, ASN58C, ASN58F, ASN64C, ASN64F, ASN65C, ASN65F, ASP179C, ASP179F, ASP206C, ASP206F, ASP239C, ASP239F, ASP240C, ASP240F, ASP282C, ASP282F, ASP44C, ASP44F, ASP87C, ASP87F, CYS207C, CYS207F, CYS49C, CYS49F, GLN237C, GLN237F, GLN268C, GLN268F, GLU233C, GLU24C, GLU24F, GLU259C, GLU259F, GLU266C, GLU266F, GLU269C, GLU269F, GLU272C, GLU272F, GLU48C, GLU48F, GLU55C, GLU55F, GLU57C, GLU57F, GLU59C, GLU59F, GLY45C, GLY45F, GLY93C, GLY93F, GLY96C, GLY96F, GLY98C, GLY98F, HIS238C, HIS238F, HIS309C, HIS309F, HIS60C, HIS60F, ILE175C, ILE175F, ILE176C, ILE176F, ILE242C, ILE242F, ILE56C, ILE56F, ILE92C, ILE92F, LEU208C, LEU208F, LEU236C, LEU236F, LEU241C, LEU241F, LEU63C, LEU63F, LEU97C, LEU97F, LEU99C, LEU99F, LYS273C, LYS273F, LYS312C, LYS312F, LYS51C, LYS51F, LYS61C, LYS61F, LYS90C, LYS90F, MET260C, MET260F, MET50C, MET50F, MET94C, MET94F, PHE100C, PHE100F, PHE265C, PHE265F, PHE53C, PHE53F, PRO177C, PRO177F, PRO46C, PRO46F, PRO47C, PRO47F, SER23F, SER261C, SER261F, SER54C, SER54F, THR212C, THR212F, THR262C, THR262F, THR263C, THR263F, THR26C, THR26F, THR89C, THR89F, TRP270C, TRP270F, TRP311C, TRP311F, TRP62C, TRP62F, TRP91C, TRP91F, TYR140C, TYR140F, TYR209C, TYR209F, TYR86C, TYR86F
• C-H: ALA217C, ALA248H, ALA249H, ALA250C, ALA250H, ALA304H, ARG194H, ARG218C, ARG222C, ARG254H, ASN252H, ASN303H, ASP183C, ASP200H, ASP202H, ASP213C, ASP226H, ASP228H, ASP239C, ASP240C, CYS299H, GLN215C, GLN223C, GLN237C, GLN245C, GLN305H, GLU225H, GLU269C, GLU272H, GLU300H, GLU331H, GLY243C, GLY275H, HIS244C, HIS301H, HIS302H, HIS328H, ILE232H, ILE242C, ILE251H, ILE276H, ILE298H, ILE329H, LEU229H, LEU236C, LEU241C, LEU247C, LEU255H, LEU271H, LYS184C, LYS216C, LYS246C, LYS273C, MET307H, PHE231H, SER277H, SER330H, THR212C, THR220C, THR253H, THR274H, TRP199H, TRP211C, TRP214C, TRP219C, TYR230H, TYR332H, VAL278H
• C-K: ASP200C, ASP200K, LYS164C, LYS164K, TRP199C, TRP199K
• C-L: ALA188C, ALA188L, ARG191C, ARG191L, GLU151C, GLU151L, GLU154C, GLU154L, GLU185C, GLU185L, GLU192C, GLU192L, GLU195C, GLU195L, LEU149C, LEU149L, LYS157C, LYS157L, LYS184C, LYS184L, SER150C, SER150L, THR148C, THR148L, VAL153C, VAL153L
• D-G: ALA131D, ALA217G, ALA248D, ALA249D, ALA250D, ALA250G, ALA304D, ARG194D, ARG218G, ARG222G, ARG254D, ASN252D, ASN303D, ASP179G, ASP183G, ASP200D, ASP202D, ASP213G, ASP228D, ASP239G, ASP240G, CYS299D, GLN215G, GLN223G, GLN237G, GLN245G, GLN305D, GLU225D, GLU272D, GLU300D, GLU331D, GLY243G, GLY275D, HIS244G, HIS301D, HIS302D, HIS328D, ILE232D, ILE242G, ILE251D, ILE276D, ILE298D, ILE329D, LEU229D, LEU236G, LEU241G, LEU247G, LEU255D, LEU271D, LYS184G, LYS216G, LYS246G, LYS273G, MET307D, PHE231D, SER277D, SER330D, THR212G, THR220G, THR253D, THR274D, TRP199D, TRP211G, TRP214G, TRP219G, TYR230D, TYR332D, VAL278D
• D-K: ALA155D, ALA155K, ALA188D, ALA188K, ARG191D, ARG191K, GLU151D, GLU151K, GLU154D, GLU154K, GLU185D, GLU185K, GLU192D, GLU192K, GLU195D, GLU195K, LEU149D, LEU149K, LYS157D, LYS157K, LYS184D, LYS184K, SER150D, SER150K, THR148D, THR148K, VAL153D, VAL153K, VAL187D
• E-F: ALA217E, ALA248F, ALA249F, ALA250E, ALA250F, ALA304F, ARG194F, ARG218E, ARG222E, ARG254F, ASN252F, ASN303F, ASP183E, ASP200F, ASP202F, ASP213E, ASP228F, ASP239E, ASP240E, CYS299F, GLN215E, GLN223E, GLN237E, GLN245E, GLN305F, GLU225F, GLU269E, GLU272F, GLU300F, GLU331F, GLY243E, GLY275F, HIS244E, HIS301F, HIS302F, HIS328F, ILE232F, ILE242E, ILE251F, ILE276F, ILE298F, ILE329F, LEU229F, LEU236E, LEU241E, LEU247E, LEU255F, LEU271F, LYS169F, LYS184E, LYS216E, LYS246E, LYS273E, MET307F, PHE231F, SER182E, SER277F, SER330F, THR212E, THR220E, THR253F, THR274F, TRP199F, TRP211E, TRP214E, TRP219E, TYR230F, TYR332F, VAL278F
• E-G: ALA113E, ALA113G, ALA121E, ALA121G, ALA128E, ALA128G, ALA5E, ALA5G, ALA80E, ALA80G, ARG264E, ARG264G, ARG294E, ARG294G, ARG73E, ARG73G, ARG79E, ARG79G, ARG84E, ARG84G, ASN6E, ASN6G, ASN81E, ASN81G, ASN83E, ASN83G, ASP297E, ASP297G, ASP74E, ASP74G, ASP87E, ASP87G, CYS299G, CYS327E, CYS327G, GLN116G, GLN129E, GLN129G, GLN268E, GLN268G, GLU269E, GLU269G, GLU272E, GLU272G, GLU300E, GLU300G, GLU77E, GLU77G, GLY114E, GLY114G, GLY118E, GLY118G, GLY126E, GLY126G, GLY127E, GLY127G, HIS301E, HIS301G, HIS302E, HIS302G, HIS328E, HIS328G, ILE295E, ILE295G, ILE298E, ILE298G, ILE325E, ILE325G, ILE329E, ILE329G, LEU117E, LEU117G, LEU124E, LEU124G, LEU292G, LEU293E, LEU293G, LEU76E, LEU76G, LYS123E, LYS123G, LYS130E, LYS130G, MET125E, MET125G, MET296E, MET296G, PHE265E, PHE265G, PHE323G, PHE78E, PHE78G, PRO120E, PRO120G, PRO75E, PRO75G, THR290E, THR290G, TYR110G, TYR122E, TYR122G, TYR82E, TYR82G, VAL119E, VAL119G, VAL326E, VAL326G
• E-H: ALA234E, ALA234H, ALA258E, ALA258H, ALA52E, ALA52H, ARG210E, ARG210H, ARG264E, ARG264H, ARG285E, ARG285H, ARG95E, ARG95H, ASN16E, ASN16H, ASN178E, ASN178H, ASN25E, ASN25H, ASN284E, ASN284H, ASN310E, ASN310H, ASN58E, ASN58H, ASN64E, ASN64H, ASN65E, ASN65H, ASP179E, ASP179H, ASP206E, ASP206H, ASP239E, ASP239H, ASP240E, ASP240H, ASP282E, ASP282H, ASP44E, ASP44H, ASP87E, ASP87H, CYS207E, CYS207H, CYS49E, CYS49H, GLN237E, GLN237H, GLN268E, GLN268H, GLU233E, GLU233H, GLU24E, GLU24H, GLU259E, GLU259H, GLU266E, GLU266H, GLU269E, GLU269H, GLU272E, GLU272H, GLU48E, GLU48H, GLU55E, GLU55H, GLU57E, GLU57H, GLU59E, GLU59H, GLY45E, GLY45H, GLY93E, GLY93H, GLY96E, GLY96H, GLY98E, GLY98H, HIS238E, HIS238H, HIS309E, HIS309H, HIS60E, HIS60H, ILE175E, ILE175H, ILE176E, ILE176H, ILE242E, ILE242H, ILE56E, ILE56H, ILE92E, ILE92H, LEU208E, LEU208H, LEU236E, LEU236H, LEU241E, LEU241H, LEU63E, LEU63H, LEU97E, LEU97H, LEU99E, LEU99H, LYS273E, LYS273H, LYS312E, LYS312H, LYS51E, LYS51H, LYS61E, LYS61H, LYS90E, LYS90H, MET260E, MET260H, MET50E, MET50H, MET94E, MET94H, PHE100E, PHE100H, PHE265E, PHE265H, PHE53E, PHE53H, PRO177E, PRO177H, PRO46E, PRO46H, PRO47E, PRO47H, SER23E, SER23H, SER261E, SER261H, SER54E, SER54H, THR212E, THR212H, THR262E, THR262H, THR263E, THR263H, THR26E, THR26H, THR89E, THR89H, TRP270E, TRP270H, TRP311E, TRP311H, TRP62E, TRP62H, TRP91E, TRP91H, TYR140E, TYR209E, TYR209H, TYR86E, TYR86H
• F-H: ALA113F, ALA113H, ALA121F, ALA121H, ALA128F, ALA128H, ALA5F, ALA5H, ALA80F, ALA80H, ARG264F, ARG264H, ARG294F, ARG294H, ARG73F, ARG73H, ARG79F, ARG79H, ARG84F, ARG84H, ASN6F, ASN6H, ASN81F, ASN81H, ASN83F, ASN83H, ASP297F, ASP297H, ASP74F, ASP74H, ASP87F, ASP87H, CYS299H, CYS327F, CYS327H, GLN116F, GLN116H, GLN129F, GLN129H, GLN268F, GLN268H, GLU269F, GLU269H, GLU272F, GLU272H, GLU300F, GLU300H, GLU77F, GLU77H, GLY114F, GLY114H, GLY118F, GLY118H, GLY126F, GLY126H, GLY127F, GLY127H, HIS301F, HIS301H, HIS302F, HIS302H, HIS328F, HIS328H, ILE295F, ILE295H, ILE298F, ILE298H, ILE325F, ILE325H, ILE329F, ILE329H, LEU117F, LEU117H, LEU124F, LEU124H, LEU292F, LEU292H, LEU293F, LEU293H, LEU76F, LEU76H, LYS123F, LYS123H, LYS130F, LYS130H, MET125F, MET125H, MET296F, MET296H, PHE265F, PHE265H, PHE323F, PHE323H, PHE78F, PHE78H, PRO120F, PRO120H, PRO75F, PRO75H, THR290F, THR290H, TYR110F, TYR110H, TYR122F, TYR122H, TYR82F, TYR82H, VAL119F, VAL119H, VAL326F, VAL326H
• G-H: ALA131G, ALA217H, ALA248G, ALA249G, ALA250G, ALA250H, ALA304G, ARG194G, ARG218H, ARG222H, ARG254G, ASN252G, ASN303G, ASP179H, ASP183H, ASP200G, ASP202G, ASP213H, ASP228G, ASP239H, ASP240H, CYS299G, GLN215H, GLN223H, GLN237H, GLN245H, GLN305G, GLU225G, GLU269H, GLU272G, GLU300G, GLU331G, GLY243H, GLY275G, HIS244H, HIS301G, HIS302G, HIS328G, ILE242H, ILE251G, ILE276G, ILE298G, ILE329G, LEU229G, LEU236H, LEU241H, LEU247H, LEU255G, LEU271G, LYS184H, LYS216H, LYS246H, LYS273H, MET307G, PHE231G, SER277G, SER330G, THR212H, THR220H, THR253G, THR274G, TRP199G, TRP211H, TRP214H, TRP219H, TYR230G, TYR332G, VAL278G
• G-V: GLU151G, GLU151V, GLU154G, GLU154V, GLU192G, GLU192V
• H-L: ASP200H, LYS164L, TRP199H, TRP199L
• H-W: GLU151H, GLU151W, GLU154H, GLU154W, GLU192H, GLU192W
• I-J: ALA217I, ALA248J, ALA249J, ALA250I, ALA250J, ALA304J, ARG194J, ARG218I, ARG222I, ARG254J, ASN252J, ASN303J, ASP200J, ASP202J, ASP213I, ASP226J, ASP228J, ASP239I, ASP240I, CYS299J, GLN215I, GLN223I, GLN237I, GLN245I, GLN305J, GLU225J, GLU269I, GLU272J, GLU300J, GLU331J, GLY243I, GLY275J, HIS244I, HIS301J, HIS302J, HIS328J, ILE232J, ILE242I, ILE251J, ILE276J, ILE298J, ILE329J, LEU229J, LEU236I, LEU241I, LEU247I, LEU255J, LEU271J, LYS184I, LYS216I, LYS246I, LYS273I, MET307J, PHE231J, SER277J, SER330J, THR212I, THR220I, THR253J, THR274J, TRP199J, TRP211I, TRP214I, TRP219I, TYR230J, TYR332J, VAL278J
• I-K: ALA113I, ALA113K, ALA121I, ALA121K, ALA128I, ALA128K, ALA5I, ALA5K, ALA80I, ALA80K, ARG264I, ARG264K, ARG294I, ARG294K, ARG73I, ARG73K, ARG79I, ARG79K, ARG84I, ARG84K, ASN6I, ASN6K, ASN81I, ASN81K, ASN83I, ASN83K, ASP297I, ASP297K, ASP74I, ASP74K, ASP87I, ASP87K, CYS299I, CYS299K, CYS327I, CYS327K, GLN116I, GLN116K, GLN129I, GLN129K, GLN268I, GLN268K, GLU269I, GLU269K, GLU272I, GLU272K, GLU300I, GLU300K, GLU77I, GLU77K, GLY114I, GLY114K, GLY118I, GLY118K, GLY126I, GLY126K, GLY127I, GLY127K, HIS301I, HIS301K, HIS302I, HIS302K, HIS328I, HIS328K, ILE295K, ILE298I, ILE298K, ILE325I, ILE325K, ILE329I, ILE329K, LEU117I, LEU117K, LEU124I, LEU124K, LEU292K, LEU293I, LEU293K, LEU76I, LEU76K, LYS123I, LYS123K, LYS130I, LYS130K, MET125I, MET125K, MET296I, MET296K, MET85I, PHE265I, PHE265K, PHE323K, PHE78I, PHE78K, PRO120I, PRO120K, PRO75I, PRO75K, THR290I, THR290K, TYR110I, TYR122I, TYR122K, TYR82I, TYR82K, VAL119I, VAL119K, VAL326I, VAL326K
• I-L: ALA234I, ALA234L, ALA258I, ALA258L, ALA52I, ALA52L, ARG210I, ARG210L, ARG264I, ARG264L, ARG285I, ARG285L, ARG95I, ARG95L, ASN16I, ASN16L, ASN178I, ASN178L, ASN25I, ASN25L, ASN284I, ASN284L, ASN310I, ASN58I, ASN58L, ASN64I, ASN64L, ASN65I, ASN65L, ASP179I, ASP179L, ASP206I, ASP206L, ASP239I, ASP239L, ASP240I, ASP240L, ASP282I, ASP282L, ASP44I, ASP44L, ASP87I, ASP87L, CYS207I, CYS207L, CYS49I, CYS49L, GLN237I, GLN237L, GLN268I, GLN268L, GLU233L, GLU24I, GLU24L, GLU259I, GLU259L, GLU266I, GLU266L, GLU269I, GLU269L, GLU272I, GLU272L, GLU48I, GLU48L, GLU55I, GLU55L, GLU57I, GLU57L, GLU59I, GLU59L, GLY45I, GLY45L, GLY93I, GLY93L, GLY96I, GLY96L, GLY98I, GLY98L, HIS238I, HIS238L, HIS309I, HIS309L, HIS60I, HIS60L, ILE175I, ILE175L, ILE176I, ILE176L, ILE242I, ILE242L, ILE56I, ILE56L, ILE92I, ILE92L, LEU208I, LEU208L, LEU236I, LEU236L, LEU241I, LEU241L, LEU63I, LEU63L, LEU97I, LEU97L, LEU99I, LEU99L, LYS273I, LYS273L, LYS312I, LYS312L, LYS51I, LYS51L, LYS61I, LYS61L, LYS90I, LYS90L, MET260I, MET260L, MET50I, MET50L, MET94I, MET94L, PHE100I, PHE100L, PHE265I, PHE265L, PHE53I, PHE53L, PRO177I, PRO177L, PRO46I, PRO46L, PRO47I, PRO47L, SER23I, SER23L, SER261I, SER261L, SER54I, SER54L, THR212I, THR212L, THR262I, THR262L, THR263I, THR263L, THR26I, THR26L, TRP270I, TRP270L, TRP311I, TRP311L, TRP62I, TRP62L, TRP91I, TRP91L, TYR140I, TYR140L, TYR209I, TYR209L, TYR86I, TYR86L
• I-N: ALA217N, ALA248I, ALA249I, ALA250I, ALA250N, ALA304I, ARG194I, ARG218N, ARG222N, ARG254I, ASN252I, ASN303I, ASP183N, ASP200I, ASP202I, ASP213N, ASP226I, ASP228I, ASP239N, ASP240N, CYS299I, GLN215N, GLN223N, GLN237N, GLN245N, GLN305I, GLU225I, GLU269N, GLU272I, GLU300I, GLU331I, GLY243N, GLY275I, HIS244N, HIS301I, HIS302I, HIS328I, ILE232I, ILE242N, ILE251I, ILE276I, ILE298I, ILE329I, LEU229I, LEU236N, LEU241N, LEU247N, LEU255I, LEU271I, LYS184N, LYS216N, LYS246N, LYS273N, MET307I, PHE231I, SER182N, SER277I, SER330I, THR212N, THR220N, THR253I, THR274I, TRP199I, TRP211N, TRP214N, TRP219N, TYR230I, TYR332I, VAL278I
• I-Q: ALA161I, ALA161Q, ARG191I, ARG191Q, ARG194I, ARG194Q, ASP200I, ASP200Q, GLU154I, GLU154Q, GLU165I, GLU165Q, GLU192I, GLU192Q, GLU195I, GLU195Q, GLY167I, GLY167Q, GLY198I, GLY198Q, ILE160I, ILE160Q, ILE197I, ILE197Q, LYS157I, LYS157Q, LYS162I, LYS162Q, LYS164I, LYS164Q, MET201I, MET201Q, PRO158I, PRO158Q, TRP199I, TRP199Q, VAL153Q, VAL196I, VAL196Q
• J-L: ALA113J, ALA121J, ALA121L, ALA128J, ALA128L, ALA5J, ALA5L, ALA80J, ALA80L, ARG264J, ARG264L, ARG294J, ARG294L, ARG73J, ARG73L, ARG79J, ARG79L, ARG84J, ARG84L, ASN6J, ASN6L, ASN81J, ASN81L, ASN83J, ASN83L, ASP297J, ASP297L, ASP74J, ASP74L, ASP87J, ASP87L, CYS299L, CYS327J, CYS327L, GLN116J, GLN116L, GLN129J, GLN129L, GLN268J, GLN268L, GLU269J, GLU269L, GLU272J, GLU272L, GLU300J, GLU300L, GLU77J, GLU77L, GLY114J, GLY114L, GLY118J, GLY118L, GLY126J, GLY126L, GLY127J, GLY127L, HIS301J, HIS301L, HIS302J, HIS302L, HIS328J, HIS328L, ILE295J, ILE295L, ILE298J, ILE298L, ILE325J, ILE325L, ILE329J, ILE329L, LEU117J, LEU117L, LEU124J, LEU124L, LEU292J, LEU292L, LEU293J, LEU293L, LEU76J, LEU76L, LYS123J, LYS123L, LYS130J, LYS130L, MET125J, MET125L, MET296J, MET296L, MET85L, PHE265J, PHE265L, PHE323J, PHE78J, PHE78L, PRO120J, PRO120L, PRO75J, PRO75L, THR290J, THR290L, TYR110J, TYR110L, TYR122J, TYR122L, TYR82J, TYR82L, TYR86L, VAL119J, VAL119L, VAL326J, VAL326L
• J-M: ALA131M, ALA217J, ALA248M, ALA249M, ALA250J, ALA250M, ALA304M, ARG194M, ARG218J, ARG222J, ARG254M, ASN252M, ASN303M, ASP179J, ASP200M, ASP202M, ASP213J, ASP226M, ASP228M, ASP239J, ASP240J, CYS299M, GLN215J, GLN223J, GLN237J, GLN245J, GLN305M, GLU225M, GLU269J, GLU272M, GLU300M, GLU331M, GLY243J, GLY275M, HIS244J, HIS301M, HIS302M, HIS328M, ILE242J, ILE251M, ILE276M, ILE298M, ILE329M, LEU229M, LEU236J, LEU241J, LEU247J, LEU255M, LEU271M, LYS169M, LYS184J, LYS216J, LYS246J, LYS273J, MET307M, PHE231M, SER182J, SER277M, SER330M, THR212J, THR253M, THR274M, TRP199M, TRP211J, TRP214J, TRP219J, TYR230M, TYR332M, VAL278M
• J-S: ASP200J, ASP200S, GLU192J, GLU192S, GLU195J, GLU195S, LYS157J, LYS157S, LYS164J, LYS164S
• J-W: ARG264J, ARG264W, ARG95J, ARG95W, ASP239J, ASP239W, GLU24J, GLU24W, GLU266J, GLU266W, GLU269J, GLU269W, GLU48W, GLU57J, GLU59J, GLU59W, HIS238J, HIS238W, LYS273J, LYS273W, LYS90J, LYS90W
• K-L: ALA131K, ALA217L, ALA248K, ALA249K, ALA250K, ALA250L, ALA304K, ARG194K, ARG218L, ARG222L, ARG254K, ASN252K, ASN303K, ASP179L, ASP183L, ASP200K, ASP202K, ASP213L, ASP228K, ASP239L, ASP240L, CYS299K, GLN215L, GLN223L, GLN237L, GLN245L, GLN305K, GLU225K, GLU272K, GLU300K, GLU331K, GLY243L, GLY275K, HIS244L, HIS301K, HIS302K, HIS328K, ILE232K, ILE242L, ILE251K, ILE276K, ILE298K, ILE329K, LEU229K, LEU236L, LEU241L, LEU247L, LEU255K, LEU271K, LYS184L, LYS216L, LYS246L, LYS273L, MET307K, PHE231K, SER277K, SER330K, THR212L, THR220L, THR253K, THR274K, TRP199K, TRP211L, TRP214L, TRP219L, TYR230K, TYR332K, VAL278K
• K-N: ALA234K, ALA234N, ALA258K, ALA258N, ALA52K, ALA52N, ARG210K, ARG210N, ARG264K, ARG264N, ARG285K, ARG285N, ARG95K, ARG95N, ASN16K, ASN16N, ASN178K, ASN178N, ASN25K, ASN25N, ASN284K, ASN284N, ASN58K, ASN58N, ASN64K, ASN64N, ASN65K, ASN65N, ASP179K, ASP179N, ASP206K, ASP206N, ASP239K, ASP239N, ASP240K, ASP240N, ASP282K, ASP282N, ASP44K, ASP44N, ASP87K, ASP87N, CYS207K, CYS207N, CYS49K, CYS49N, GLN237K, GLN237N, GLN268K, GLN268N, GLU233K, GLU24K, GLU24N, GLU259K, GLU259N, GLU266K, GLU266N, GLU269K, GLU269N, GLU272K, GLU272N, GLU48K, GLU48N, GLU55K, GLU55N, GLU57K, GLU57N, GLU59K, GLU59N, GLY45K, GLY45N, GLY93K, GLY93N, GLY96K, GLY96N, GLY98K, GLY98N, HIS238K, HIS238N, HIS309K, HIS309N, HIS60K, HIS60N, ILE175K, ILE175N, ILE176K, ILE176N, ILE242K, ILE242N, ILE56K, ILE56N, ILE92K, ILE92N, LEU208K, LEU208N, LEU236K, LEU241K, LEU241N, LEU63K, LEU63N, LEU97K, LEU97N, LEU99K, LEU99N, LYS273K, LYS273N, LYS312K, LYS312N, LYS51K, LYS51N, LYS61K, LYS61N, LYS90K, LYS90N, MET260K, MET260N, MET50K, MET50N, MET94K, MET94N, PHE100K, PHE100N, PHE265K, PHE265N, PHE53K, PHE53N, PRO177K, PRO177N, PRO46K, PRO46N, PRO47K, PRO47N, SER23K, SER261K, SER261N, SER54K, SER54N, THR212K, THR212N, THR262K, THR262N, THR263K, THR263N, THR26N, THR89N, TRP270K, TRP270N, TRP311K, TRP311N, TRP62K, TRP62N, TRP91K, TRP91N, TYR140K, TYR140N, TYR209K, TYR209N, TYR86K, TYR86N
• K-V: ARG218K, ARG222K, ARG254V, ASN252V, ASP213K, ASP228V, ASP239K, ASP240K, GLN215K, GLU300V, GLU331V, HIS301V, HIS302V, LYS216K, LYS246K, SER277V
• L-W: ARG218W, ARG222W, ARG254L, ASN252L, ASP213W, ASP228L, ASP239W, ASP240W, GLU300L, GLU331L, HIS301L, HIS302L, LYS216W, LYS246W
• M-N: ALA131N, ALA217M, ALA248N, ALA249N, ALA250M, ALA250N, ALA304N, ARG194N, ARG218M, ARG222M, ARG254N, ASN252N, ASN303N, ASP179M, ASP200N, ASP202N, ASP213M, ASP226N, ASP228N, ASP239M, ASP240M, CYS299N, GLN215M, GLN223M, GLN237M, GLN245M, GLN305N, GLU225N, GLU269M, GLU272N, GLU300N, GLU331N, GLY243M, GLY275N, HIS244M, HIS301N, HIS302N, HIS328N, ILE232N, ILE242M, ILE251N, ILE276N, ILE298N, ILE329N, LEU229N, LEU236M, LEU241M, LEU247M, LEU255N, LEU271N, LYS184M, LYS216M, LYS246M, LYS273M, MET307N, PHE231N, SER182M, SER277N, SER330N, THR212M, THR220M, THR253N, THR274N, TRP199N, TRP211M, TRP214M, TRP219M, TYR230N, TYR332N, VAL278N
• M-V: ARG264M, ARG264V, ARG285V, ARG95M, ARG95V, ASP239M, ASP239V, GLU24M, GLU24V, GLU266M, GLU266V, GLU269M, GLU269V, GLU48M, GLU57V, GLU59M, GLU59V, HIS238M, HIS238V, LYS273M, LYS273V, LYS90M, LYS90V, TRP91M
• M-W: ALA80M, ALA80W, ARG264M, ARG264W, ARG294M, ARG294W, ARG79M, ARG79W, ASN83W, ASP297M, ASP297W, ASP74M, ASP74W, ASP87M, GLN129M, GLU300M, GLU300W, GLU77M, GLU77W, GLY126M, GLY126W, HIS301M, HIS301W, HIS328M, HIS328W, LYS123M, LYS123W
• M-X: ASP200M, ASP200X, GLU165M, GLU165X, GLU192M, GLU192X, GLU195M, GLU195X, LYS157M, LYS157X, LYS164M, LYS164X
• N-Q: GLU185N, GLU185Q, GLU192N, GLU195N, GLU195Q, LYS184N, LYS184Q, SER150N, SER150Q, THR148N, THR148Q
• N-R: ASP200N, ASP200R, GLU154R, GLU192N, GLU192R, GLU195N, GLU195R, LYS157N, LYS157R, LYS164N, LYS164R
• N-V: ALA80N, ALA80V, ARG264N, ARG264V, ARG294N, ARG294V, ARG79N, ARG79V, ASP297N, ASP297V, ASP74N, ASP74V, GLU300N, GLU300V, GLU77N, GLU77V, GLY126N, GLY126V, HIS301N, HIS301V, HIS328N, HIS328V, LYS123N, LYS123V
• O-P: ALA217O, ALA248P, ALA249P, ALA250O, ALA250P, ALA304P, ARG194P, ARG218O, ARG222O, ARG254P, ASN252P, ASN303P, ASP183O, ASP202P, ASP213O, ASP226P, ASP228P, ASP239O, ASP240O, CYS299P, GLN215O, GLN223O, GLN237O, GLN245O, GLN305P, GLU225P, GLU269O, GLU272P, GLU300P, GLU331P, GLY243O, GLY275P, HIS244O, HIS301P, HIS302P, HIS328P, ILE232P, ILE242O, ILE251P, ILE276P, ILE298P, ILE329P, LEU229P, LEU236O, LEU241O, LEU247O, LEU255P, LEU271P, LYS184O, LYS216O, LYS246O, LYS273O, MET307P, PHE231P, SER277P, SER330P, THR212O, THR220O, THR253P, THR274P, TRP199P, TRP211O, TRP214O, TRP219O, TYR230P, TYR332P, VAL278P
• O-Q: ALA113O, ALA113Q, ALA121O, ALA121Q, ALA128O, ALA128Q, ALA5O, ALA5Q, ALA80O, ALA80Q, ARG264O, ARG264Q, ARG294O, ARG294Q, ARG73O, ARG73Q, ARG79O, ARG79Q, ARG84O, ARG84Q, ASN6O, ASN6Q, ASN81O, ASN81Q, ASN83O, ASN83Q, ASP297O, ASP297Q, ASP365Q, ASP74O, ASP74Q, ASP87O, ASP87Q, CYS327O, CYS327Q, GLN116O, GLN116Q, GLN129O, GLN129Q, GLN268O, GLN268Q, GLU269O, GLU269Q, GLU272O, GLU272Q, GLU300O, GLU300Q, GLU77O, GLU77Q, GLY114O, GLY114Q, GLY118O, GLY118Q, GLY126O, GLY126Q, GLY127O, GLY127Q, HIS301O, HIS301Q, HIS302O, HIS302Q, HIS328O, HIS328Q, ILE295O, ILE295Q, ILE298O, ILE298Q, ILE325O, ILE325Q, ILE329O, ILE329Q, LEU117O, LEU117Q, LEU124O, LEU124Q, LEU292O, LEU292Q, LEU293O, LEU293Q, LEU76O, LEU76Q, LYS123O, LYS123Q, LYS130O, LYS130Q, LYS90O, MET125O, MET125Q, MET296O, MET296Q, MET85O, PHE265O, PHE265Q, PHE323Q, PHE78O, PHE78Q, PRO120O, PRO120Q, PRO75O, PRO75Q, THR290O, THR290Q, TYR110Q, TYR122O, TYR122Q, TYR82O, TYR82Q, TYR86O, VAL119O, VAL119Q, VAL326O, VAL326Q
• O-S: ARG264O, ARG264S, ARG95O, ARG95S, ASP239O, ASP239S, GLU24O, GLU24S, GLU266O, GLU266S, GLU269O, GLU269S, GLU48O, GLU48S, GLU57O, GLU57S, GLU59O, GLU59S, HIS238O, HIS238S, LYS273O, LYS273S, LYS90O, LYS90S
• O-U: ARG218U, ARG222U, ARG254O, ASP213U, ASP239U, ASP240U, GLU225O, GLU300O, GLU331O, HIS301O, HIS302O, LYS216U, LYS246U
• P-S: ALA80P, ALA80S, ARG264P, ARG264S, ARG294P, ARG294S, ARG79P, ARG79S, ASP297P, ASP297S, ASP74P, ASP74S, ASP87S, GLU300P, GLU300S, GLU77P, GLU77S, GLY126P, GLY126S, HIS301P, HIS301S, HIS328P, HIS328S, LYS123P, LYS123S
• P-T: ARG218P, ARG222P, ARG254T, ASN252T, ASP213P, ASP239P, ASP240P, GLU300T, GLU331T, HIS301T, HIS302T, LYS216P, LYS246P
• P-X: ARG264P, ARG264X, ARG95P, ARG95X, ASP239P, ASP239X, GLU24P, GLU266P, GLU266X, GLU269P, GLU269X, GLU48P, GLU48X, GLU55P, GLU57X, GLU59X, HIS238P, HIS238X, LYS273P, LYS273X, LYS90P, LYS90X
• Q-R: ARG218Q, ARG222Q, ARG254R, ASN252R, ASP213Q, ASP239Q, ASP240Q, GLU225R, GLU300R, GLU331R, HIS301R, HIS302R, LYS216Q, LYS246Q
• Q-S: ARG218S, ARG222S, ARG254Q, ASP213S, ASP239S, ASP240S, GLU225Q, GLU300Q, GLU331Q, HIS301Q, HIS302Q, LYS216S, LYS246S
• Q-U: ARG264Q, ARG264U, ARG95Q, ARG95U, ASP239Q, ASP239U, GLU24U, GLU266Q, GLU266U, GLU269Q, GLU269U, GLU48Q, GLU48U, GLU55Q, GLU55U, GLU57U, GLU59Q, HIS238Q, HIS238U, LYS273Q, LYS273U, LYS90Q, LYS90U, TYR86U
• R-T: ARG264R, ARG264T, ARG95R, ARG95T, ASN25R, ASP239R, ASP239T, GLU24R, GLU24T, GLU266R, GLU266T, GLU269R, GLU269T, GLU48R, GLU57T, GLU59R, GLU59T, HIS238R, HIS238T, LYS273R, LYS273T, LYS90R, LYS90T, TYR86T
• R-U: ALA80R, ALA80U, ARG264R, ARG264U, ARG294R, ARG294U, ARG79R, ARG79U, ASP297R, ASP297U, ASP74R, ASP74U, ASP87U, GLU300R, GLU300U, GLU77R, GLU77U, GLY126R, GLY126U, HIS301R, HIS301U, HIS328R, HIS328U, LYS123R, LYS123U
• R-X: ARG218R, ARG222R, ARG254X, ASN252X, ASP213R, ASP239R, ASP240R, GLU225X, GLU300X, GLU331X, HIS301X, HIS302X, LYS216R, LYS246R
• S-X: ARG218X, ARG222X, ARG254S, ASP213X, ASP239X, ASP240X, GLU225S, GLU300S, GLU331S, HIS301S, HIS302S, LYS216X, LYS246X
• T-U: ARG218T, ARG222T, ARG254U, ASN252U, ASP213T, ASP239T, ASP240T, GLU225U, GLU300U, GLU331U, HIS301U, HIS302U, LYS216T, LYS246T
• T-X: ALA128X, ALA80T, ALA80X, ARG264T, ARG264X, ARG294T, ARG294X, ARG79T, ARG79X, ASN83T, ASP297T, ASP297X, ASP74T, ASP74X, ASP87T, ASP87X, GLN129X, GLU300T, GLU300X, GLU77T, GLU77X, GLY126T, GLY126X, HIS301T, HIS301X, HIS328T, HIS328X, LYS123T, LYS123X
• V-W: ARG218V, ARG254W, ASP213V, ASP239V, ASP240V, GLN215V, GLU300W, GLU331W, HIS301W, HIS302W, LYS216V, LYS246V, SER277W