3MQ7

crystal structure of ectodomain mutant of bst-2/tetherin/cd317

• Total interactions analyzed: 66
• Total true interactions: 33
• Strongest Interaction:
  • Chains: A-J
  • Int. Res.: 8
  • Norm. En. per Res.: -4.1466
• Hub Node: E(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	0.0	-22.506	-298.215	-320.721	158	10	35	16207	2	47	56
A-C	-46.0825	-17.2523	-175.016	-238.3508	72	21	16	8534	0	12	13
A-D	0.0	84.8107	-121.297	-36.4863	72	5	18	7053	0	26	22
A-J	-4.8905	-23.4339	-4.8488	-33.1732	8	1	0	211	1	9	9
B-C	0.0	78.7775	-125.365	-46.5875	71	5	19	7108	0	26	22
B-D	-10.4119	-15.8965	-184.566	-210.8744	72	16	16	8254	0	12	11
B-I	0.0	0.0	-0.1145	-0.1145	4	0	0	45	0	7	9
B-J	0.0	-29.0798	-29.6981	-58.7779	27	1	0	1134	3	4	3
B-L	-40.4355	-5.6462	-36.6249	-82.7066	47	6	1	2566	3	16	17
C-D	0.0	-21.9964	-324.975	-346.9714	158	13	39	16670	2	47	56
D-J	-5.7705	10.5235	-22.9987	-18.2457	34	3	0	1334	1	13	9
D-L	0.0	0.0	-0.0024	-0.0024	2	0	0	2	0	2	1
E-F	0.0	-26.0484	-343.343	-369.3914	159	11	35	16948	1	47	56
E-G	-26.0814	-15.6733	-196.811	-238.5657	73	20	16	8559	0	12	11
E-H	0.0	48.604	-162.535	-113.931	72	9	20	7799	0	27	22
E-I	-35.4899	-7.9782	-134.535	-178.0031	103	15	4	6779	0	39	34
E-J	0.0	0.0	-0.0226	-0.0226	3	0	0	19	0	4	2
E-K	-29.8573	-48.3846	-100.289	-178.5309	54	5	0	4148	4	20	12
F-G	0.0	44.0512	-135.45	-91.3988	70	4	18	6857	0	26	22
F-H	-45.5172	-10.6185	-156.967	-213.1027	73	24	15	8821	0	11	12
F-I	0.0	0.0	-0.0089	-0.0089	3	0	0	7	0	2	2
G-H	0.0	-29.7325	-343.05	-372.7825	162	22	44	18105	4	46	53
G-I	0.0	34.3747	-16.3875	17.9872	19	4	0	574	0	5	9
G-K	-16.9364	-23.2925	-64.2399	-104.4688	65	6	1	2994	1	15	9
G-L	0.0	0.0	-5.6177	-5.6177	25	0	0	567	0	10	10
H-K	-2.9218	-11.5227	-3.9041	-18.3486	17	0	0	263	1	11	7
H-L	-17.6819	7.0781	-80.5732	-91.177	40	20	1	3861	0	14	14
I-J	-2.5527	-31.3885	-370.421	-404.3622	158	17	35	17114	2	47	56
I-K	-14.3768	-17.1026	-210.254	-241.7335	73	11	16	8541	0	10	11
I-L	0.0	47.3753	-149.395	-102.0197	71	4	19	7372	0	27	22
J-K	0.0	48.6204	-146.305	-97.6846	70	1	19	7290	0	26	22
J-L	-41.5998	-18.4364	-194.344	-254.3802	71	15	15	8425	0	12	12
K-L	0.0	-13.931	-345.449	-359.38	157	14	36	17112	3	47	57

Interface residues

• A-B: ALA100A, ALA100B, ALA104A, ALA104B, ALA107A, ALA107B, ALA130A, ALA130B, ALA132A, ALA132B, ALA149A, ALA149B, ALA59A, ALA59B, ALA63A, ALA63B, ALA77A, ALA77B, ALA88A, ALA88B, ALA91A, ALA91B, ALA97A, ALA97B, ARG136A, ARG136B, ARG138A, ARG138B, ARG139A, ARG139B, ARG147A, ARG147B, ASN124A, ASN124B, ASN141A, ASN141B, ASN92A, ASN92B, ASP103A, ASP103B, ASP129A, ASP129B, ASP83A, ASP83B, GLN108A, GLN108B, GLN110A, GLN110B, GLN128A, GLN128B, GLN142A, GLN142B, GLN71A, GLN71B, GLN78A, GLN78B, GLN82A, GLN82B, GLN87A, GLN87B, GLU105A, GLU105B, GLU114A, GLU114B, GLU115A, GLU115B, GLU117A, GLU117B, GLU119A, GLU119B, GLU133A, GLU133B, GLU135A, GLU135B, GLU140A, GLU140B, GLU73A, GLU73B, GLU76A, GLU76B, GLU85A, GLU85B, GLY109A, GLY109B, GLY118A, GLY118B, GLY56A, GLY56B, GLY80A, GLY80B, HIS125A, HIS125B, HIS93A, HIS93B, ILE120A, ILE120B, ILE148A, ILE148B, LEU102A, LEU102B, LEU116A, LEU116B, LEU123A, LEU123B, LEU127A, LEU127B, LEU137A, LEU137B, LEU144A, LEU144B, LEU70A, LEU70B, LEU74A, LEU74B, LEU98A, LEU98B, LYS106A, LYS106B, LYS112A, LYS112B, LYS126A, LYS126B, LYS79A, LYS79B, PHE81A, PHE81B, SER101A, SER101B, SER131A, SER131B, SER145A, SER145B, THR121A, THR121B, THR122A, THR122B, THR67A, THR67B, THR90A, THR90B, THR94A, THR94B, VAL113A, VAL113B, VAL134A, VAL134B, VAL143A, VAL143B, VAL146A, VAL146B, VAL60A, VAL60B, VAL66A, VAL66B, VAL84A, VAL84B, VAL95A, VAL95B
• A-C: ALA52A, ALA52C, ALA53A, ALA53C, ALA59A, ALA59C, ALA63A, ALA63C, ALA77A, ALA77C, ALA86A, ALA86C, ALA88A, ALA88C, ARG54A, ARG54C, ARG58A, ARG58C, ARG64A, ARG64C, ASN65A, ASN65C, ASP55A, ASP55C, ASP83A, ASP83C, GLN71A, GLN71C, GLN72A, GLN72C, GLN78A, GLN78C, GLN82A, GLN82C, GLU51A, GLU51C, GLU62A, GLU62C, GLU73A, GLU73C, GLU76A, GLU76C, GLU85A, GLU85C, GLY56A, GLY56C, GLY80A, GLY80C, HIS68A, HIS68C, LEU57A, LEU57C, LEU69A, LEU69C, LEU70A, LEU70C, LEU74A, LEU74C, LYS79A, LYS79C, PHE81A, PHE81C, THR67A, THR67C, THR75A, THR75C, VAL60A, VAL60C, VAL66A, VAL66C, VAL84A, VAL84C
• A-D: ALA52A, ALA52D, ALA53A, ALA53D, ALA59A, ALA59D, ALA63A, ALA63D, ALA77A, ALA77D, ARG54A, ARG54D, ARG58A, ARG58D, ARG64A, ARG64D, ASN65A, ASN65D, ASP55A, ASP55D, ASP83A, ASP83D, CB8.6218214.68331, GLN71A, GLN71D, GLN72A, GLN72D, GLN78A, GLN78D, GLN82A, GLN82D, GLN87A, GLN87D, GLU51A, GLU51A5, GLU51D, GLU62A, GLU62D, GLU73A, GLU73D, GLU76A, GLU76D, GLU85A, GLU85D, GLY56A, GLY56D, GLY80A, GLY80D, HIS68A, HIS68D, LEU57A, LEU57D, LEU69A, LEU69D, LEU70A, LEU70D, LEU74A, LEU74D, LYS79A, LYS79D, PHE81A, PHE81D, THR67A, THR67D, THR75A, THR75D, VAL60A, VAL60D, VAL66A, VAL66D, VAL84A, VAL84D
• A-J: ALA59A, ALA63A, ARG58A, ASP55A, GLU115J, GLU62A, LYS111J, VAL66A
• B-C: ALA52B, ALA52C, ALA53B, ALA53C, ALA59B, ALA59C, ALA63B, ALA63C, ALA77B, ALA77C, ALA86C, ARG54B, ARG54C, ARG58B, ARG58C, ARG64B, ARG64C, ASN65B, ASN65C, ASP55B, ASP55C, ASP83B, ASP83C, GLN71B, GLN71C, GLN72B, GLN72C, GLN78B, GLN78C, GLN82B, GLN82C, GLN87B, GLN87C, GLU51B, GLU51C, GLU62B, GLU62C, GLU73B, GLU73C, GLU76B, GLU76C, GLU85B, GLU85C, GLY56B, GLY56C, GLY80B, GLY80C, HIS68B, HIS68C, LEU57B, LEU57C, LEU69B, LEU69C, LEU70B, LEU70C, LEU74B, LEU74C, LYS79B, LYS79C, PHE81B, PHE81C, THR67B, THR67C, THR75B, THR75C, VAL60B, VAL60C, VAL66B, VAL66C, VAL84B, VAL84C
• B-D: ALA52B, ALA52D, ALA53B, ALA53D, ALA59B, ALA59D, ALA63B, ALA63D, ALA77B, ALA77D, ALA86B, ALA86D, ALA88B, ALA88D, ARG54B, ARG54D, ARG58B, ARG58D, ARG64B, ARG64D, ASN65B, ASN65D, ASP55B, ASP55D, ASP83B, ASP83D, GLN71B, GLN71D, GLN72B, GLN72D, GLN78B, GLN78D, GLN82B, GLN82D, GLU51B, GLU51D, GLU62B, GLU62D, GLU73B, GLU73D, GLU76B, GLU76D, GLU85B, GLU85D, GLY56B, GLY56D, GLY80B, GLY80D, HIS68B, HIS68D, LEU57B, LEU57D, LEU69B, LEU69D, LEU70B, LEU70D, LEU74B, LEU74D, LYS79B, LYS79D, PHE81B, PHE81D, THR67B, THR67D, THR75B, THR75D, VAL60B, VAL60D, VAL66B, VAL66D, VAL84B, VAL84D
• B-I: ALA59I, GLU62I, LYS111B, VAL66I
• B-J: ALA100B, ALA86B, ALA86J, ALA88B, ALA88J, ALA89B, ALA89J, ALA97B, ALA97J, ASN92B, ASN92J, ASP83B, ASP83J, GLN78B, GLN78J, GLN82B, GLN82J, GLU85B, GLU85J, HIS93B, HIS93J, PHE81B, PHE81J, THR90B, THR90J, THR94J, VAL84J
• B-L: ALA100B, ALA104B, ALA107B, ALA53L, ALA63L, ALA77L, ALA88B, ALA89B, ALA91B, ALA97B, ARG54L, ARG58L, ARG64L, ASN65L, ASN92B, ASP103B, GLN108B, GLN110B, GLN71L, GLN72L, GLU105B, GLU114B, GLU115B, GLU119B, GLU51L, GLU62L, GLU73L, GLU76L, GLY109B, HIS68L, HIS93B, LEU102B, LEU57L, LEU69L, LEU70L, LEU74L, LEU98B, LYS106B, LYS111B, LYS112B, LYS79L, SER101B, THR75L, THR94B, VAL60L, VAL66L, VAL95B
• C-D: ALA100C, ALA100D, ALA104C, ALA104D, ALA107C, ALA107D, ALA130C, ALA130D, ALA132C, ALA132D, ALA149C, ALA149D, ALA59C, ALA59D, ALA63C, ALA63D, ALA77C, ALA77D, ALA88C, ALA88D, ALA91C, ALA91D, ALA97C, ALA97D, ARG136C, ARG136D, ARG138C, ARG138D, ARG139C, ARG139D, ARG147C, ARG147D, ASN124C, ASN124D, ASN141C, ASN141D, ASN92C, ASN92D, ASP103C, ASP103D, ASP129C, ASP129D, ASP83C, ASP83D, GLN108C, GLN108D, GLN110C, GLN110D, GLN128C, GLN128D, GLN142C, GLN142D, GLN71C, GLN71D, GLN78C, GLN78D, GLN82C, GLN82D, GLN87C, GLN87D, GLU105C, GLU105D, GLU114C, GLU114D, GLU115C, GLU115D, GLU117C, GLU117D, GLU119C, GLU119D, GLU133C, GLU133D, GLU135C, GLU135D, GLU140C, GLU140D, GLU73C, GLU73D, GLU76C, GLU76D, GLU85C, GLU85D, GLY109C, GLY109D, GLY118C, GLY118D, GLY56C, GLY56D, GLY80C, GLY80D, HIS125C, HIS125D, HIS93C, HIS93D, ILE120C, ILE120D, ILE148C, ILE148D, LEU102C, LEU102D, LEU116C, LEU116D, LEU123C, LEU123D, LEU127C, LEU127D, LEU137C, LEU137D, LEU144C, LEU144D, LEU70C, LEU70D, LEU74C, LEU74D, LEU98C, LEU98D, LYS106C, LYS106D, LYS112C, LYS112D, LYS126C, LYS126D, LYS79C, LYS79D, PHE81C, PHE81D, SER101C, SER101D, SER131C, SER131D, SER145C, SER145D, THR121C, THR121D, THR122C, THR122D, THR67C, THR67D, THR90C, THR90D, THR94C, THR94D, VAL113C, VAL113D, VAL134C, VAL134D, VAL143C, VAL143D, VAL146C, VAL146D, VAL60C, VAL60D, VAL66C, VAL66D, VAL84C, VAL84D, VAL95C, VAL95D
• D-J: ALA100J, ALA104J, ALA107J, ALA53D, ALA63D, ALA88J, ALA89J, ALA97J, ARG54D, ARG58D, ARG64D, ASN65D, ASN92J, ASP103J, GLN108J, GLN72D, GLU105J, GLU115J, GLU62D, GLU73D, GLU76D, HIS68D, HIS93J, LEU102J, LEU57D, LEU69D, LEU98J, LYS111J, LYS112J, SER101J, THR90J, THR94J, VAL66D, VAL95J
• D-L: ARG54D, GLU51L
• E-F: ALA100E, ALA100F, ALA104E, ALA104F, ALA107E, ALA107F, ALA130E, ALA130F, ALA132E, ALA132F, ALA149E, ALA149F, ALA59E, ALA59F, ALA63E, ALA63F, ALA77E, ALA77F, ALA88E, ALA88F, ALA91E, ALA91F, ALA97E, ALA97F, ARG136E, ARG136F, ARG138E, ARG138F, ARG139E, ARG139F, ARG147E, ARG147F, ASN124E, ASN124F, ASN141E, ASN141F, ASN92E, ASN92F, ASP103E, ASP103F, ASP129E, ASP129F, ASP83E, ASP83F, GLN108E, GLN108F, GLN110E, GLN110F, GLN128E, GLN128F, GLN142E, GLN142F, GLN71E, GLN71F, GLN78E, GLN78F, GLN82E, GLN82F, GLN87E, GLN87F, GLU105E, GLU105F, GLU114E, GLU114F, GLU115E, GLU115F, GLU117E, GLU117F, GLU119E, GLU119F, GLU133E, GLU133F, GLU135E, GLU135F, GLU140E, GLU140F, GLU73E, GLU73F, GLU76E, GLU76F, GLU85E, GLU85F, GLY109E, GLY109F, GLY118E, GLY118F, GLY56E, GLY56F, GLY80E, GLY80F, HIS125E, HIS125F, HIS93E, HIS93F, ILE120E, ILE120F, ILE148E, ILE148F, LEU102E, LEU102F, LEU116E, LEU116F, LEU123E, LEU123F, LEU127E, LEU127F, LEU137E, LEU137F, LEU144E, LEU144F, LEU57E, LEU70E, LEU70F, LEU74E, LEU74F, LEU98E, LEU98F, LYS106E, LYS106F, LYS112E, LYS112F, LYS126E, LYS126F, LYS79E, LYS79F, PHE81E, PHE81F, SER101E, SER101F, SER131E, SER131F, SER145E, SER145F, THR121E, THR121F, THR122E, THR122F, THR67E, THR67F, THR90E, THR90F, THR94E, THR94F, VAL113E, VAL113F, VAL134E, VAL134F, VAL143E, VAL143F, VAL146E, VAL146F, VAL60E, VAL60F, VAL66E, VAL66F, VAL84E, VAL84F, VAL95E, VAL95F
• E-G: ALA52E, ALA52G, ALA53E, ALA53G, ALA59E, ALA59G, ALA63E, ALA63G, ALA77E, ALA77G, ALA86E, ALA86G, ALA88E, ALA88G, ALA89G, ARG54E, ARG54G, ARG58E, ARG58G, ARG64E, ARG64G, ASN65E, ASN65G, ASN92G, ASP55E, ASP55G, ASP83E, ASP83G, GLN71E, GLN71G, GLN72E, GLN72G, GLN78E, GLN78G, GLN82E, GLN82G, GLU51E, GLU51G, GLU62E, GLU62G, GLU73E, GLU73G, GLU76E, GLU76G, GLU85E, GLU85G, GLY56E, GLY56G, GLY80E, GLY80G, HIS68E, HIS68G, LEU57E, LEU57G, LEU69G, LEU70E, LEU70G, LEU74E, LEU74G, LYS79E, LYS79G, PHE81E, PHE81G, THR67E, THR67G, THR75E, THR75G, VAL60E, VAL60G, VAL66E, VAL66G, VAL84E, VAL84G
• E-H: ALA52E, ALA52H, ALA53E, ALA53H, ALA59E, ALA59H, ALA63E, ALA63H, ALA77E, ALA77H, ALA86H, ALA88H, ARG54E, ARG54H, ARG58E, ARG58H, ARG64E, ARG64H, ASN65E, ASN65H, ASP55E, ASP55H, ASP83E, ASP83H, GLN71E, GLN71H, GLN72E, GLN72H, GLN78E, GLN78H, GLN82E, GLN82H, GLN87E, GLN87H, GLU51E, GLU51H, GLU62E, GLU62H, GLU73E, GLU73H, GLU76E, GLU76H, GLU85E, GLU85H, GLY56E, GLY56H, GLY80E, GLY80H, HIS68E, HIS68H, LEU57E, LEU57H, LEU69E, LEU69H, LEU70E, LEU70H, LEU74E, LEU74H, LYS79E, LYS79H, PHE81E, PHE81H, THR67E, THR67H, THR75E, THR75H, VAL60E, VAL60H, VAL66E, VAL66H, VAL84E, VAL84H
• E-I: ALA100E, ALA100I, ALA104E, ALA104I, ALA107E, ALA107I, ALA86E, ALA86I, ALA88E, ALA88I, ALA89E, ALA89I, ALA91E, ALA97E, ALA97I, ARG136E, ARG64I, ASN124E, ASN65I, ASN92E, ASN92I, ASP103E, ASP103I, ASP129E, ASP83E, ASP83I, GLN108E, GLN108I, GLN110E, GLN110I, GLN128I, GLN71E, GLN71I, GLN72E, GLN72I, GLN78E, GLN78I, GLN82E, GLN82I, GLN87E, GLN87I, GLU105E, GLU105I, GLU114E, GLU114I, GLU115E, GLU115I, GLU117E, GLU117I, GLU119E, GLU133E, GLU76E, GLU85E, GLU85I, GLY109E, GLY109I, GLY118E, GLY118I, HIS125E, HIS125I, HIS68E, HIS68I, HIS93E, HIS93I, ILE120E, LEU102E, LEU102I, LEU116E, LEU123E, LEU127E, LEU57I, LEU69I, LEU70I, LEU74E, LEU74I, LEU98E, LEU98I, LYS106I, LYS111E, LYS111I, LYS112E, LYS112I, LYS126E, LYS79E, LYS79I, PHE81E, PHE81I, SER101E, SER101I, THR121E, THR121I, THR122E, THR67I, THR75E, THR75I, THR90E, THR90I, THR94E, THR94I, VAL113E, VAL113I, VAL84I, VAL95I
• E-J: LEU102J, LYS106J, LYS111E
• E-K: ALA86E, ALA86K, ALA89E, ALA89K, ARG64E, ARG64K, ASN65E, ASN65K, ASP83E, ASP83K, GLN71E, GLN71K, GLN72E, GLN72K, GLN78E, GLN78K, GLN82E, GLN82K, GLN87E, GLN87K, GLU73E, GLU73K, GLU76E, GLU76K, GLU85E, GLU85K, GLY80E, GLY80K, HIS68E, HIS68K, HIS93E, HIS93K, LEU57E, LEU57K, LEU69E, LEU69K, LEU70E, LEU70K, LEU74E, LEU74K, LYS79E, LYS79K, PHE81E, PHE81K, THR67E, THR67K, THR75E, THR75K, THR90E, THR90K, VAL60E, VAL60K, VAL84E, VAL84K
• F-G: ALA52F, ALA52G, ALA53F, ALA53G, ALA59F, ALA59G, ALA63F, ALA63G, ALA77F, ALA77G, ARG54F, ARG54G, ARG58F, ARG58G, ARG64F, ARG64G, ASN65F, ASN65G, ASP55F, ASP55G, ASP83F, ASP83G, GLN71F, GLN71G, GLN72F, GLN72G, GLN78F, GLN78G, GLN82F, GLN82G, GLN87F, GLN87G, GLU51F, GLU51G, GLU62F, GLU62G, GLU73F, GLU73G, GLU76F, GLU76G, GLU85F, GLU85G, GLY56F, GLY56G, GLY80F, GLY80G, HIS68F, HIS68G, LEU57F, LEU57G, LEU69F, LEU69G, LEU70F, LEU70G, LEU74F, LEU74G, LYS79F, LYS79G, PHE81F, PHE81G, THR67F, THR67G, THR75F, THR75G, VAL60F, VAL60G, VAL66F, VAL66G, VAL84F, VAL84G
• F-H: ALA52F, ALA52H, ALA53F, ALA53H, ALA59F, ALA59H, ALA63F, ALA63H, ALA77F, ALA77H, ALA86F, ALA86H, ALA88F, ALA88H, ARG54F, ARG54H, ARG58F, ARG58H, ARG64F, ARG64H, ASN65F, ASN65H, ASN92F, ASP55F, ASP55H, ASP83F, ASP83H, GLN71F, GLN71H, GLN72F, GLN72H, GLN78F, GLN78H, GLN82F, GLN82H, GLU51F, GLU51H, GLU62F, GLU62H, GLU73F, GLU73H, GLU76F, GLU76H, GLU85F, GLU85H, GLY56F, GLY56H, GLY80F, GLY80H, HIS68F, HIS68H, LEU57F, LEU57H, LEU69F, LEU69H, LEU70F, LEU70H, LEU74F, LEU74H, LYS79F, LYS79H, PHE81F, PHE81H, THR67F, THR67H, THR75F, THR75H, VAL60F, VAL60H, VAL66F, VAL66H, VAL84F, VAL84H
• F-I: HIS93I, LEU102F, LYS106F
• G-H: ALA100G, ALA100H, ALA104G, ALA104H, ALA107G, ALA107H, ALA130G, ALA130H, ALA132G, ALA132H, ALA149G, ALA149H, ALA59G, ALA59H, ALA63G, ALA63H, ALA77G, ALA77H, ALA86G, ALA86H, ALA88G, ALA88H, ALA89G, ALA89H, ALA91G, ALA91H, ALA97G, ALA97H, ARG136G, ARG136H, ARG138G, ARG138H, ARG139G, ARG139H, ARG147G, ARG147H, ASN124G, ASN124H, ASN141G, ASN141H, ASN92G, ASN92H, ASP103G, ASP103H, ASP129G, ASP129H, ASP83G, ASP83H, GLN108G, GLN108H, GLN110G, GLN110H, GLN128G, GLN128H, GLN142G, GLN142H, GLN71G, GLN71H, GLN78G, GLN78H, GLN82G, GLN82H, GLN87G, GLN87H, GLU105G, GLU105H, GLU114G, GLU114H, GLU115G, GLU115H, GLU117G, GLU117H, GLU119G, GLU119H, GLU133G, GLU133H, GLU135G, GLU135H, GLU140G, GLU140H, GLU73G, GLU73H, GLU76G, GLU76H, GLU85G, GLU85H, GLY109G, GLY109H, GLY118G, GLY118H, GLY56G, GLY56H, GLY80G, GLY80H, HIS125G, HIS125H, HIS93G, HIS93H, ILE120G, ILE120H, ILE148G, ILE148H, LEU102G, LEU102H, LEU116G, LEU116H, LEU123G, LEU123H, LEU127G, LEU127H, LEU137G, LEU137H, LEU144G, LEU144H, LEU70G, LEU70H, LEU74G, LEU74H, LEU98G, LEU98H, LYS106G, LYS106H, LYS112G, LYS112H, LYS126G, LYS126H, LYS79G, LYS79H, PHE81G, PHE81H, SER101G, SER101H, SER131G, SER131H, SER145G, SER145H, THR121G, THR121H, THR122G, THR122H, THR67G, THR67H, THR90G, THR90H, THR94G, THR94H, VAL113G, VAL113H, VAL134G, VAL134H, VAL143G, VAL143H, VAL146G, VAL146H, VAL60G, VAL60H, VAL66G, VAL66H, VAL84G, VAL84H, VAL95G, VAL95H
• G-I: ARG54G, ARG54I, ARG58G, ARG58I, ARG64G, ARG64I, ASN65G, ASN65I, GLN71G, GLN71I, GLN72G, GLN72I, HIS68G, HIS68I, LEU57G, LEU57I, THR67G, THR67I, THR75G
• G-K: ALA100K, ALA104G, ALA104K, ALA86G, ALA86K, ALA88K, ALA89G, ALA89K, ALA91K, ALA97G, ALA97K, ARG64G, ASN65G, ASN92K, ASP83G, ASP83K, GLN108G, GLN108K, GLN71G, GLN71K, GLN72G, GLN72K, GLN78G, GLN78K, GLN82G, GLN82K, GLN87G, GLN87K, GLU105G, GLU105K, GLU115K, GLU119K, GLU73G, GLU76G, GLU85G, GLU85K, GLY80G, HIS68G, HIS93G, HIS93K, LEU116K, LEU123K, LEU57G, LEU69G, LEU70G, LEU74G, LEU74K, LEU98G, LEU98K, LYS112G, LYS112K, LYS126K, LYS79G, LYS79K, PHE81G, SER101G, SER101K, THR67G, THR75G, THR75K, THR90G, THR90K, THR94G, THR94K, VAL84G
• G-L: ALA104G, ALA130G, ALA132L, ARG139L, ASN124L, ASP129G, GLN108G, GLN128L, GLU115G, GLU117L, GLU119G, GLU135L, HIS125L, HIS93G, ILE120L, LEU102L, LEU123G, LEU127G, LEU127L, LYS106L, LYS111G, LYS112G, LYS126G, SER131L, THR121L
• H-K: ALA52H, ARG136K, ASP103H, GLN128H, GLU114H, GLU115K, GLU117H, GLU133K, HIS68K, LEU102H, LEU123K, LEU137K, LYS106H, LYS111K, LYS112K, LYS126K, VAL113H
• H-L: ALA130H, ALA132H, ALA132L, ALA149L, ARG136H, ARG136L, ARG138H, ARG138L, ARG139H, ARG139L, ARG147L, ASN124H, ASN141L, ASP129H, GLN128H, GLN142L, GLU117H, GLU133H, GLU135H, GLU135L, GLU140H, GLU140L, HIS125H, ILE120H, ILE148L, LEU123H, LEU127H, LEU127L, LEU137H, LEU137L, LEU144L, LYS126H, SER131H, SER131L, SER145L, THR121H, VAL134H, VAL134L, VAL143L, VAL146L
• I-J: ALA100I, ALA100J, ALA104I, ALA104J, ALA107I, ALA107J, ALA130I, ALA130J, ALA132I, ALA132J, ALA149I, ALA149J, ALA59I, ALA59J, ALA63I, ALA63J, ALA77I, ALA77J, ALA88I, ALA88J, ALA91I, ALA91J, ALA97I, ALA97J, ARG136I, ARG136J, ARG138I, ARG138J, ARG139I, ARG139J, ARG147I, ARG147J, ASN124I, ASN124J, ASN141I, ASN141J, ASN92I, ASN92J, ASP103I, ASP103J, ASP129I, ASP129J, ASP83I, ASP83J, GLN108I, GLN108J, GLN110I, GLN110J, GLN128I, GLN128J, GLN142I, GLN142J, GLN71I, GLN71J, GLN78I, GLN78J, GLN82I, GLN82J, GLN87I, GLN87J, GLU105I, GLU105J, GLU114I, GLU114J, GLU115I, GLU115J, GLU117I, GLU117J, GLU119I, GLU119J, GLU133I, GLU133J, GLU135I, GLU135J, GLU140I, GLU140J, GLU73I, GLU73J, GLU76I, GLU76J, GLU85I, GLU85J, GLY109I, GLY109J, GLY118I, GLY118J, GLY56I, GLY56J, GLY80I, GLY80J, HIS125I, HIS125J, HIS93I, HIS93J, ILE120I, ILE120J, ILE148I, ILE148J, LEU102I, LEU102J, LEU116I, LEU116J, LEU123I, LEU123J, LEU127I, LEU127J, LEU137I, LEU137J, LEU144I, LEU144J, LEU70I, LEU70J, LEU74I, LEU74J, LEU98I, LEU98J, LYS106I, LYS106J, LYS112I, LYS112J, LYS126I, LYS126J, LYS79I, LYS79J, PHE81I, PHE81J, SER101I, SER101J, SER131I, SER131J, SER145I, SER145J, THR121I, THR121J, THR122I, THR122J, THR67I, THR67J, THR90I, THR90J, THR94I, THR94J, VAL113I, VAL113J, VAL134I, VAL134J, VAL143I, VAL143J, VAL146I, VAL146J, VAL60I, VAL60J, VAL66I, VAL66J, VAL84I, VAL84J, VAL95I, VAL95J
• I-K: ALA52I, ALA52K, ALA53I, ALA53K, ALA59I, ALA59K, ALA63I, ALA63K, ALA77I, ALA77K, ALA86I, ALA86K, ALA88I, ALA88K, ARG54I, ARG54K, ARG58I, ARG58K, ARG64I, ARG64K, ASN65I, ASN65K, ASN92K, ASP55I, ASP55K, ASP83I, ASP83K, GLN71I, GLN71K, GLN72I, GLN72K, GLN78I, GLN78K, GLN82I, GLN82K, GLU51I, GLU51K, GLU62I, GLU62K, GLU73I, GLU73K, GLU76I, GLU76K, GLU85I, GLU85K, GLY56I, GLY56K, GLY80I, GLY80K, HIS68I, HIS68K, LEU57I, LEU57K, LEU69I, LEU69K, LEU70I, LEU70K, LEU74I, LEU74K, LYS79I, LYS79K, PHE81I, PHE81K, THR67I, THR67K, THR75I, THR75K, VAL60I, VAL60K, VAL66I, VAL66K, VAL84I, VAL84K
• I-L: ALA52I, ALA52L, ALA53I, ALA53L, ALA59I, ALA59L, ALA63I, ALA63L, ALA77I, ALA77L, ALA86I, ARG54I, ARG54L, ARG58I, ARG58L, ARG64I, ARG64L, ASN65I, ASN65L, ASP55I, ASP55L, ASP83I, ASP83L, GLN71I, GLN71L, GLN72I, GLN72L, GLN78I, GLN78L, GLN82I, GLN82L, GLN87I, GLN87L, GLU51I, GLU51L, GLU62I, GLU62L, GLU73I, GLU73L, GLU76I, GLU76L, GLU85I, GLU85L, GLY56I, GLY56L, GLY80I, GLY80L, HIS68I, HIS68L, LEU57I, LEU57L, LEU69I, LEU69L, LEU70I, LEU70L, LEU74I, LEU74L, LYS79I, LYS79L, PHE81I, PHE81L, THR67I, THR67L, THR75I, THR75L, VAL60I, VAL60L, VAL66I, VAL66L, VAL84I, VAL84L
• J-K: ALA52J, ALA52K, ALA53J, ALA53K, ALA59J, ALA59K, ALA63J, ALA63K, ALA77J, ALA77K, ARG54J, ARG54K, ARG58J, ARG58K, ARG64J, ARG64K, ASN65J, ASN65K, ASP55J, ASP55K, ASP83J, ASP83K, GLN71J, GLN71K, GLN72J, GLN72K, GLN78J, GLN78K, GLN82J, GLN82K, GLN87J, GLN87K, GLU51J, GLU51K, GLU62J, GLU62K, GLU73J, GLU73K, GLU76J, GLU76K, GLU85J, GLU85K, GLY56J, GLY56K, GLY80J, GLY80K, HIS68J, HIS68K, LEU57J, LEU57K, LEU69J, LEU69K, LEU70J, LEU70K, LEU74J, LEU74K, LYS79J, LYS79K, PHE81J, PHE81K, THR67J, THR67K, THR75J, THR75K, VAL60J, VAL60K, VAL66J, VAL66K, VAL84J, VAL84K
• J-L: ALA52J, ALA52L, ALA53J, ALA53L, ALA59J, ALA59L, ALA63J, ALA63L, ALA77J, ALA77L, ALA86J, ALA86L, ALA88J, ALA88L, ARG54J, ARG54L, ARG58J, ARG58L, ARG64J, ARG64L, ASN65J, ASN65L, ASP55J, ASP55L, ASP83J, ASP83L, GLN71J, GLN71L, GLN72J, GLN72L, GLN78J, GLN78L, GLN82J, GLN82L, GLU51J, GLU51L, GLU62J, GLU62L, GLU73J, GLU73L, GLU76J, GLU76L, GLU85J, GLU85L, GLY56J, GLY56L, GLY80J, GLY80L, HIS68J, HIS68L, LEU57J, LEU57L, LEU69J, LEU70J, LEU70L, LEU74J, LEU74L, LYS79J, LYS79L, PHE81J, PHE81L, THR67J, THR67L, THR75J, THR75L, VAL60J, VAL60L, VAL66J, VAL66L, VAL84J, VAL84L
• K-L: ALA100K, ALA100L, ALA104K, ALA104L, ALA107K, ALA107L, ALA130K, ALA130L, ALA132K, ALA132L, ALA149K, ALA149L, ALA59K, ALA63K, ALA63L, ALA77K, ALA77L, ALA88K, ALA88L, ALA91K, ALA91L, ALA97K, ALA97L, ARG136K, ARG136L, ARG138K, ARG138L, ARG139K, ARG139L, ARG147K, ARG147L, ASN124K, ASN124L, ASN141K, ASN141L, ASN92K, ASN92L, ASP103K, ASP103L, ASP129K, ASP129L, ASP83K, ASP83L, GLN108K, GLN108L, GLN110K, GLN110L, GLN128K, GLN128L, GLN142K, GLN142L, GLN71K, GLN71L, GLN78K, GLN78L, GLN82K, GLN82L, GLN87K, GLN87L, GLU105K, GLU105L, GLU114K, GLU114L, GLU115K, GLU115L, GLU117K, GLU117L, GLU119K, GLU119L, GLU133K, GLU133L, GLU135K, GLU135L, GLU140K, GLU140L, GLU73K, GLU73L, GLU76K, GLU76L, GLU85K, GLU85L, GLY109K, GLY109L, GLY118K, GLY118L, GLY56K, GLY56L, GLY80K, GLY80L, HIS125K, HIS125L, HIS93K, HIS93L, ILE120K, ILE120L, ILE148K, ILE148L, LEU102K, LEU102L, LEU116K, LEU116L, LEU123K, LEU123L, LEU127K, LEU127L, LEU137K, LEU137L, LEU144K, LEU144L, LEU70K, LEU70L, LEU74K, LEU74L, LEU98K, LEU98L, LYS106K, LYS106L, LYS112K, LYS112L, LYS126K, LYS126L, LYS79K, LYS79L, PHE81K, PHE81L, SER101K, SER101L, SER131K, SER131L, SER145K, SER145L, THR121K, THR121L, THR122K, THR122L, THR67K, THR67L, THR90K, THR90L, THR94K, THR94L, VAL113K, VAL113L, VAL134K, VAL134L, VAL143K, VAL143L, VAL146K, VAL146L, VAL60K, VAL60L, VAL66K, VAL66L, VAL84K, VAL84L, VAL95K, VAL95L