3MOP

the ternary death domain complex of myd88, irak4, and irak2

• Total interactions analyzed: 91
• Total true interactions: 40
• Strongest Interaction:
  • Chains: B-C
  • Int. Res.: 37
  • Norm. En. per Res.: -3.7752
• Hub Node: G(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-3.0827	-31.0666	-49.2225	-83.3718	35	8	3	2840	2	11	10
A-D	-5.1619	-55.5506	-143.857	-204.5695	59	13	2	5804	2	30	26
A-E	-2.2279	13.7753	-102.424	-90.8765	62	13	3	5032	0	15	14
B-C	-8.0474	-76.5765	-55.0583	-139.6823	37	4	3	3138	5	11	12
B-E	-6.984	-50.5625	-112.498	-170.0445	60	25	2	5692	6	27	25
B-F	-13.972	13.5999	-97.6635	-98.0356	62	8	3	4713	0	15	12
C-D	0.0	0.0	-48.7363	-48.7363	39	2	1	2687	2	10	11
C-F	-40.0889	-37.6049	-111.341	-189.0348	51	17	3	4687	1	29	25
C-G	-22.4317	-24.0795	-112.649	-159.1602	54	20	1	5342	0	13	13
D-E	0.0	0.0	-43.9477	-43.9477	33	4	1	2447	0	10	10
D-G	-5.8018	-1.3741	-81.2354	-88.4113	45	3	4	3503	2	15	6
D-H	-28.067	-23.5441	-113.801	-165.4121	55	18	1	5586	0	13	13
E-F	-7.3955	0.0	-37.9237	-45.3192	32	3	1	2181	0	10	9
E-H	-26.0063	-2.7295	-78.2173	-106.953	46	6	4	3768	3	15	6
E-I	-27.8314	-29.9842	-130.7	-188.5157	53	14	1	5385	1	13	13
F-G	0.0	4.1141	-61.0255	-56.9114	41	7	2	2728	1	11	12
F-I	-20.507	-2.8084	-69.6417	-92.9571	48	11	3	3752	2	13	6
F-J	-9.6248	-22.3669	-131.255	-163.2467	54	15	1	5646	0	13	13
G-H	-14.9559	-35.6106	-54.588	-105.1545	42	5	1	2577	3	9	11
G-I	0.0	0.0	-0.6047	-0.6047	4	0	0	62	0	0	0
G-J	0.0	-10.643	-99.6158	-110.2588	56	15	2	5118	0	15	16
G-K	-9.3288	-24.5872	-132.552	-166.468	52	22	1	5751	0	5	9
H-I	-14.4104	-26.9056	-48.7508	-90.0668	41	2	0	2291	2	8	11
H-J	0.0	0.0	-0.7874	-0.7874	3	0	0	101	0	0	0
H-K	-10.0958	24.1001	-102.726	-88.7216	52	12	0	4500	3	15	17
H-L	-18.4965	-23.0751	-140.571	-182.1426	54	12	1	5841	0	6	9
I-J	0.0	-21.115	-31.7878	-52.9027	38	4	0	2188	1	8	11
I-K	0.0	0.0	-10.5598	-10.5598	11	0	0	387	0	0	0
I-L	-11.5992	23.1777	-110.863	-99.2844	50	13	0	4679	1	15	17
I-M	-15.3146	-29.7921	-132.054	-177.1607	59	6	1	5447	0	7	9
J-K	0.0	7.8521	-25.0542	-17.2021	26	2	0	1341	0	8	7
J-L	0.0	0.0	-13.2132	-13.2132	11	0	0	410	0	0	0
J-M	-16.1253	4.107	-123.467	-135.4853	60	16	0	5264	3	15	18
J-N	-9.4058	-32.496	-111.298	-153.1998	52	5	1	4856	0	7	9
K-L	0.0	2.144	-44.5918	-42.4478	34	1	0	2484	0	14	9
K-M	0.0	0.0	-7.8585	-7.8585	9	0	0	353	0	0	0
K-N	-5.1119	3.4322	-108.234	-109.9137	56	9	3	5028	1	12	14
L-M	0.0	5.1136	-24.2831	-19.1695	32	0	0	1700	0	14	8
L-N	0.0	0.0	-3.8513	-3.8513	6	0	0	242	0	0	0
M-N	0.0	1.3981	-24.7773	-23.3792	35	1	0	1594	0	14	8

Interface residues

• A-B: ALA68A, ALA77B, ARG31A, ARG32A, ARG40A, ARG62B, ARG81B, ARG98A, ASN38A, ASP100A, ASP69A, GLN42A, GLN63B, GLN67A, GLN67B, GLU104A, GLU57B, GLU60B, GLU65B, ILE61B, LEU35A, LEU37A, LEU59B, LEU64B, PHE36A, PHE56B, PRO70A, SER34A, THR41A, THR66A, THR66B, THR71A, TYR58B, VAL101A, VAL39A
• A-D: ALA119D, ALA120D, ALA23D, ALA24D, ALA44A, ALA45A, ALA49A, ALA51A, ALA68D, ALA77D, ARG28D, ARG30D, ARG31D, ARG32D, ARG40A, ARG62A, ARG73D, ASN26D, ASN38D, ASP112D, ASP46A, ASP55A, ASP69D, ASP76D, GLN42A, GLN63A, GLN67D, GLN79D, GLU52A, GLU53A, GLU57A, GLU60A, GLU65A, GLY72D, ILE61A, LEU22D, LEU25D, LEU35D, LEU50A, LEU59A, LEU64A, LEU75D, LEU96A, LYS115D, LYS95A, MET27D, PHE56A, PRO21D, PRO70D, SER108D, SER34D, THR41A, THR48A, THR71D, TRP47A, TYR116D, TYR58A, VAL29D, VAL43A
• A-E: ALA120E, ALA23E, ALA24E, ALA44A, ALA45A, ALA51E, ALA77E, ALA84E, ARG28A, ARG30E, ARG32A, ARG40A, ARG62E, ARG73E, ARG81E, ARG98A, ASP100A, ASP46A, ASP76E, ASP99A, GLN42A, GLN63E, GLN67E, GLN79E, GLU104A, GLU122E, GLU57E, GLU60E, GLU65E, GLY80E, GLY83E, GLY97A, HIS123E, ILE117E, ILE61E, LEU102A, LEU103A, LEU121E, LEU20E, LEU22E, LEU35A, LEU37A, LEU59E, LEU64E, LEU74E, LEU75E, LEU96A, LYS115A, MET19E, PHE36A, PHE56E, PRO21E, PRO82E, SER108A, SER85E, THR41A, THR66E, TRP78E, TYR116E, VAL101A, VAL39A, VAL43A
• B-C: ALA68B, ALA77C, ARG28B, ARG31B, ARG32B, ARG40B, ARG62C, ARG81C, ARG98B, ASN38B, ASP100B, ASP69B, GLN42B, GLN63C, GLN67B, GLN67C, GLU104B, GLU57C, GLU60C, GLU65C, ILE61C, LEU33B, LEU35B, LEU37B, LEU59C, LEU64C, PHE36B, PHE56C, PRO70B, SER34B, THR41B, THR66C, THR71B, TRP47B, TYR58C, VAL101B, VAL39B
• B-E: ALA119E, ALA120E, ALA23E, ALA24E, ALA44B, ALA45B, ALA49B, ALA51B, ALA68E, ALA77E, ARG28E, ARG30E, ARG31E, ARG32E, ARG40B, ARG62B, ARG73E, ASN26E, ASN38E, ASP112E, ASP46B, ASP55B, ASP69E, ASP76E, GLN42B, GLN67E, GLN79E, GLU111E, GLU52B, GLU53B, GLU57B, GLU60B, GLU65B, GLY72E, ILE61B, LEU22E, LEU25E, LEU33E, LEU35E, LEU50B, LEU59B, LEU75E, LEU96B, LYS115E, LYS95B, MET27E, MET54B, PHE56B, PRO21E, PRO70E, SER34E, THR41B, THR48B, THR71E, TRP47B, TYR116E, TYR58B, VAL29E, VAL39B, VAL43B
• B-F: ALA119F, ALA120F, ALA23F, ALA24F, ALA44B, ALA45B, ALA51F, ALA77F, ALA84F, ARG28B, ARG30F, ARG32B, ARG40B, ARG73F, ARG81F, ARG98B, ASP100B, ASP46B, ASP76F, ASP99B, GLN42B, GLN63F, GLN67F, GLN79F, GLU104B, GLU111B, GLU122F, GLU57F, GLU60F, GLU65F, GLY80F, GLY83F, GLY97B, HIS123F, ILE61F, LEU102B, LEU103B, LEU105B, LEU121F, LEU20F, LEU22F, LEU35B, LEU37B, LEU59F, LEU64F, LEU74F, LEU75F, LEU96B, MET19F, PHE36B, PHE56F, PRO21F, PRO82F, SER108B, SER85F, THR41B, THR66F, TRP78F, TYR116F, VAL101B, VAL39B, VAL43B
• C-D: ALA68C, ALA77D, ARG31C, ARG32C, ARG40C, ARG62D, ARG73D, ARG81D, ARG98C, ASN38C, ASP100C, ASP69C, GLN42C, GLN63D, GLN67C, GLN67D, GLU104C, GLU57D, GLU60D, GLU65D, ILE61D, LEU105C, LEU33C, LEU35C, LEU37C, LEU59D, LEU64D, PHE36C, PHE56D, PRO70C, SER34C, THR41C, THR66C, THR66D, THR71C, TRP47C, TYR58D, VAL101C, VAL39C
• C-F: ALA119F, ALA120F, ALA23F, ALA24F, ALA44C, ALA49C, ALA51C, ALA68F, ALA77F, ARG28F, ARG30F, ARG31F, ARG40C, ARG62C, ARG73F, ASN26F, ASN38F, ASP112F, ASP46C, ASP55C, ASP69F, ASP76F, GLN42C, GLN67F, GLN79F, GLU52C, GLU53C, GLU57C, GLU60C, GLU65C, GLY72F, ILE61C, LEU22F, LEU25F, LEU35F, LEU50C, LEU59C, LEU75F, LYS115F, LYS95C, MET27F, MET54C, PHE56C, PRO21F, THR41C, THR48C, TRP47C, TYR116F, TYR58C, VAL29F, VAL43C
• C-G: ALA44C, ALA45C, ALA58G, ARG12G, ARG32C, ARG40C, ARG47G, ARG54G, ARG55G, ARG98C, ASN38C, ASN49G, ASN78G, ASP100C, ASP46C, ASP73G, ASP99C, CYS13G, CYS79G, GLN42C, GLU104C, GLU57G, GLU69G, GLY75G, GLY97C, HIS52G, ILE39G, ILE53G, LEU102C, LEU103C, LEU105C, LEU35C, LEU37C, LEU59G, LEU70G, LEU96C, LYS41G, LYS64G, MET2G, PHE36C, PHE51G, PHE56G, PHE72G, PRO66G, THR41C, THR62G, THR76G, THR77G, TRP74G, TYR10G, TYR48G, VAL101C, VAL39C, VAL43C
• D-E: ALA68D, ARG31D, ARG32D, ARG40D, ARG62E, ARG98D, ASN38D, ASP100D, ASP69D, GLN42D, GLN63E, GLN67E, GLU104D, GLU57E, GLU60E, GLU65E, GLY72D, ILE61E, LEU33D, LEU35D, LEU37D, LEU59E, LEU64E, PHE36D, PRO70D, SER34D, THR41D, THR66E, THR71D, TRP47D, TYR58E, VAL101D, VAL39D
• D-G: ALA44D, ALA45D, ALA49D, ALA51D, ARG12G, ARG20G, ARG40D, ARG62D, ASN15G, ASP24G, ASP46D, ASP55D, ASP73G, CYS13G, GLN42D, GLU52D, GLU53D, GLU57D, GLU60D, GLU65D, GLU69G, GLY17G, GLY63G, GLY75G, ILE19G, ILE61D, LEU14G, LEU18G, LEU59D, LEU70G, LEU71G, LYS64G, MET2G, PHE56D, PHE72G, SER65G, SER68G, THR41D, THR48D, THR76G, TRP47D, TYR58D, VAL11G, VAL16G, VAL43D
• D-H: ALA36H, ALA44D, ALA45D, ALA58H, ARG12H, ARG32D, ARG40D, ARG47H, ARG55H, ARG98D, ASN38D, ASN49H, ASN78H, ASP100D, ASP46D, ASP73H, ASP99D, CYS13H, CYS79H, GLN42D, GLU104D, GLU57H, GLU69H, GLY75H, GLY97D, HIS52H, ILE39H, ILE53H, LEU102D, LEU103D, LEU105D, LEU35D, LEU37D, LEU59H, LEU70H, LEU71H, LEU96D, LYS41H, LYS64H, PHE36D, PHE51H, PHE56H, PHE72H, PRO66H, SER68H, THR41D, THR62H, THR76H, THR77H, TRP74H, TYR10H, TYR48H, VAL101D, VAL39D, VAL43D
• E-F: ALA68E, ARG31E, ARG32E, ARG40E, ARG62F, ARG98E, ASN38E, ASP100E, ASP69E, GLN42E, GLN63F, GLN67F, GLU104E, GLU57F, GLU60F, GLU65F, GLY72E, ILE61F, LEU33E, LEU35E, LEU37E, LEU59F, LEU64F, PHE36E, PRO70E, SER34E, THR41E, THR66F, THR71E, TYR58F, VAL101E, VAL39E
• E-H: ALA44E, ALA45E, ALA49E, ALA51E, ARG12H, ARG20H, ARG40E, ARG62E, ASN15H, ASP24H, ASP46E, ASP73H, CYS13H, GLN42E, GLU52E, GLU53E, GLU57E, GLU60E, GLU65E, GLU69H, GLY17H, GLY63H, GLY75H, ILE19H, ILE61E, LEU14H, LEU18H, LEU50E, LEU59E, LEU70H, LEU71H, LYS64H, PHE56E, PHE72H, SER65H, SER68H, THR41E, THR48E, THR67H, THR76H, TRP47E, TYR10H, TYR58E, VAL11H, VAL16H, VAL43E
• E-I: ALA44E, ALA45E, ALA58I, ARG12I, ARG32E, ARG40E, ARG47I, ARG54I, ARG55I, ARG98E, ASN38E, ASN49I, ASN78I, ASP100E, ASP46E, ASP73I, ASP99E, CYS13I, CYS79I, GLN42E, GLU104E, GLU57I, GLU69I, GLY75I, GLY97E, HIS52I, ILE39I, ILE53I, LEU102E, LEU103E, LEU105E, LEU35E, LEU37E, LEU59I, LEU70I, LEU96E, LYS64I, PHE36E, PHE51I, PHE56I, PHE72I, PRO66I, THR41E, THR62I, THR76I, THR77I, TRP74I, TYR10I, TYR48I, VAL101E, VAL11I, VAL39E, VAL43E
• F-G: ALA58G, ALA68F, ARG30F, ARG31F, ARG32F, ARG40F, ARG54G, ARG55G, ARG98F, ASN38F, ASN49G, ASP100F, ASP69F, ASP73G, GLN50G, GLN61G, GLN67F, GLU104F, GLU57G, GLU65F, GLY72F, HIS52G, ILE53G, LEU105F, LEU33F, LEU35F, LEU37F, LEU59G, LYS64G, PHE36F, PHE51G, PHE56G, PRO70F, SER34F, THR41F, THR62G, THR66F, THR71F, VAL101F, VAL29F, VAL39F
• F-I: ALA44F, ALA45F, ALA49F, ALA51F, ARG12I, ARG20I, ARG40F, ARG62F, ASN15I, ASP46F, ASP55F, ASP73I, CYS13I, GLN42F, GLU52F, GLU53F, GLU57F, GLU60F, GLU65F, GLU69I, GLY17I, GLY63I, GLY75I, ILE19I, ILE61F, LEU14I, LEU18I, LEU50F, LEU59F, LEU70I, LEU71I, LYS64I, MET2I, PHE56F, PHE72I, SER65I, SER68I, THR41F, THR48F, THR62I, THR67I, THR76I, TRP47F, TYR58F, VAL11I, VAL16I, VAL39F, VAL43F
• F-J: ALA36J, ALA44F, ALA45F, ALA58J, ARG12J, ARG40F, ARG47J, ARG54J, ARG55J, ARG98F, ASN38F, ASN49J, ASN78J, ASP100F, ASP46F, ASP73J, ASP99F, CYS13J, CYS79J, GLN42F, GLU104F, GLU57J, GLU69J, GLY75J, GLY97F, HIS52J, ILE39J, ILE53J, LEU102F, LEU103F, LEU105F, LEU35F, LEU37F, LEU59J, LEU70J, LEU71J, LEU96F, LYS41J, LYS64J, PHE36F, PHE51J, PHE56J, PHE72J, PRO66J, SER68J, THR41F, THR76J, THR77J, TRP74J, TYR10J, TYR48J, VAL101F, VAL39F, VAL43F
• G-H: ALA58G, ALA58H, ALA95G, ARG20G, ARG54H, ARG55H, ASN49H, ASP24G, ASP27G, ASP73H, GLN29G, GLN50H, GLN61G, GLN61H, GLU30G, GLU57G, GLU57H, GLY17G, GLY63G, GLY63H, HIS52H, ILE19G, ILE26G, LEU18G, LEU22G, LEU59G, LEU59H, LEU60G, LEU60H, LEU99G, LYS21G, LYS64G, LYS64H, PHE25G, PHE51H, PRO28G, PRO66G, PRO96G, SER23G, SER65G, THR62G, THR62H
• G-I: GLN61G, GLY63I, LYS64I, THR62I
• G-J: ALA36G, ALA38G, ARG12J, ARG20J, ARG54G, ARG55G, ASN15J, ASN49G, ASP45G, ASP46G, ASP73J, CYS13J, GLN29G, GLN50G, GLN61G, GLU30G, GLU57G, GLU69J, GLY17J, GLY31G, GLY3J, GLY44G, GLY63J, GLY75J, HIS52G, ILE19J, ILE53G, LEU14J, LEU18J, LEU22J, LEU35G, LEU70J, LEU71J, LYS33G, LYS34G, LYS40G, LYS64J, MET2J, PHE51G, PHE56G, PHE72J, PHE93G, PRO28G, PRO4J, SER43G, SER65J, SER68J, THR67J, THR76J, TRP32G, TRP74J, TYR10J, TYR48G, VAL11J, VAL16J, VAL37G
• G-K: ALA69K, ALA95G, ALA97G, ARG58K, ARG67K, ASN91G, ASP24G, ASP27G, GLN29G, GLN41K, GLN68K, GLN73K, GLN7K, GLU108G, GLU30G, GLU59K, GLU92G, GLY31G, GLY65K, ILE26G, ILE36K, ILE45K, ILE5K, LEU107G, LEU22G, LEU60K, LEU61K, LEU88G, LEU99G, LYS34G, LYS44K, MET48K, MET66K, PHE25G, PHE93G, PHE94G, PRO102G, PRO106G, PRO28G, PRO96G, SER23G, SER98G, THR37K, THR70K, TRP32G, TRP62K, TRP63K, TRP64K, TYR4K, TYR6K, VAL105G, VAL35K
• H-I: ALA58H, ALA58I, ALA95H, ARG20H, ARG54I, ARG55I, ASN49I, ASP24H, ASP27H, ASP73I, GLN29H, GLN50I, GLN61H, GLN61I, GLU30H, GLU57H, GLU57I, GLY17H, GLY63H, GLY63I, HIS52I, ILE19H, ILE26H, LEU22H, LEU59H, LEU59I, LEU60H, LEU99H, LYS21H, LYS64H, LYS64I, PHE25H, PHE51I, PRO28H, PRO66H, PRO96H, SER23H, SER65H, THR62H, THR62I, TRP32H
• H-J: GLN61H, LYS64J, THR62J
• H-K: ALA36H, ALA38H, ARG18K, ARG47H, ARG54H, ARG55H, ARG58K, ASN49H, ASP14K, ASP15K, ASP45H, ASP46H, CYS17K, GLN29H, GLN50H, GLN52K, GLN7K, GLU30H, GLU57H, GLU59K, GLY44H, GLY53K, GLY65K, HIS52H, ILE53H, ILE5K, LEU13K, LEU16K, LEU60H, LEU60K, LEU61K, LEU8K, LYS33H, LYS34H, LYS40H, MET66K, PHE51H, PRO9K, SER10K, SER55K, THR57K, TRP11K, TRP32H, TRP62K, TRP63K, TRP93K, TYR48H, TYR4K, TYR6K, VAL12K, VAL37H, VAL54K
• H-L: ALA69L, ALA95H, ALA97H, ARG58L, ARG67L, ASN91H, ASP24H, ASP27H, CYS3L, GLN29H, GLN41L, GLN68L, GLN73L, GLN7L, GLU108H, GLU30H, GLU59L, GLU92H, GLY31H, GLY65L, ILE26H, ILE36L, ILE45L, ILE56L, ILE5L, LEU107H, LEU60L, LEU61L, LEU88H, LEU99H, LYS33H, LYS34H, LYS44L, MET48L, MET66L, PHE25H, PHE93H, PHE94H, PRO106H, PRO28H, PRO96H, SER23H, SER55L, SER98H, THR37L, THR70L, TRP32H, TRP62L, TRP63L, TRP64L, TYR4L, TYR6L, VAL105H, VAL35L
• I-J: ALA58J, ALA95I, ARG20I, ARG54J, ARG55J, ASP24I, ASP27I, ASP73J, GLN29I, GLN50J, GLN61I, GLN61J, GLU30I, GLU57I, GLU57J, GLY17I, GLY63I, GLY63J, HIS52J, ILE19I, LEU18I, LEU22I, LEU59I, LEU59J, LEU60I, LEU99I, LYS21I, LYS64I, LYS64J, PHE25I, PHE51J, PRO28I, PRO66I, PRO96I, SER23I, THR62I, THR62J, TRP32I
• I-K: ALA58I, GLN52K, GLN61I, GLU57I, GLY53K, GLY63I, LEU59I, LEU60I, THR62I, VAL51K, VAL54K
• I-L: ALA36I, ALA38I, ARG18L, ARG47I, ARG54I, ARG58L, ASN49I, ASP14L, ASP15L, ASP45I, ASP46I, CYS17L, GLN29I, GLN50I, GLN52L, GLN7L, GLU30I, GLU57I, GLU59L, GLY44I, GLY53L, GLY65L, HIS52I, ILE45L, ILE53I, ILE5L, LEU13L, LEU60I, LEU60L, LEU61L, LEU8L, LYS33I, LYS34I, LYS40I, MET66L, PHE51I, PRO9L, SER10L, SER55L, THR57L, TRP11L, TRP62L, TRP63L, TRP93L, TYR48I, TYR4L, TYR6L, VAL12L, VAL37I, VAL54L
• I-M: ALA104I, ALA69M, ALA95I, ALA97I, ARG58M, ARG67M, ASN91I, ASP24I, ASP27I, ASP38M, GLN29I, GLN41M, GLN68M, GLN73M, GLN7M, GLU108I, GLU30I, GLU59M, GLU92I, GLY31I, GLY65M, ILE26I, ILE36M, ILE45M, ILE56M, ILE5M, ILE89I, LEU107I, LEU22I, LEU60M, LEU61M, LEU88I, LEU99I, LYS33I, LYS34I, LYS44M, MET48M, MET66M, PHE25I, PHE93I, PHE94I, PRO102I, PRO106I, PRO28I, PRO96I, SER23I, SER55M, SER98I, THR37M, THR57M, THR70M, TRP32I, TRP62M, TRP63M, TRP64M, TYR4M, TYR6M, VAL105I, VAL35M
• J-K: ALA58J, ARG20J, ARG43K, ASP24J, ASP27J, GLN29J, GLN41K, GLN52K, GLN61J, GLY63J, LEU39K, LEU59J, LEU60J, LYS21J, LYS44K, LYS64J, MET48K, PHE25J, PRO28J, SER47K, THR40K, THR62J, TRP50K, TRP63K, VAL51K, VAL54K
• J-L: ALA58J, GLN52L, GLN61J, GLU57J, GLY53L, GLY63J, LEU59J, LEU60J, THR62J, VAL51L, VAL54L
• J-M: ALA36J, ALA38J, ARG18M, ARG47J, ARG54J, ARG55J, ARG58M, ASN49J, ASN91J, ASP14M, ASP15M, ASP45J, ASP46J, CYS17M, GLN29J, GLN50J, GLN52M, GLN7M, GLU30J, GLU57J, GLU59M, GLY44J, GLY53M, GLY65M, HIS52J, ILE39J, ILE53J, ILE5M, LEU13M, LEU16M, LEU35J, LEU60J, LEU60M, LEU61M, LEU8M, LYS33J, LYS34J, LYS40J, MET48M, MET66M, PHE51J, PHE56J, PRO28J, PRO9M, SER10M, SER55M, THR57M, TRP11M, TRP32J, TRP62M, TRP63M, TRP64M, TRP93M, TYR48J, TYR4M, TYR6M, VAL12M, VAL37J, VAL51M, VAL54M
• J-N: ALA104J, ALA69N, ALA95J, ALA97J, ARG58N, ARG67N, ASN91J, ASP24J, ASP27J, GLN29J, GLN41N, GLN68N, GLN73N, GLN7N, GLU108J, GLU30J, GLU59N, GLU92J, GLY31J, GLY65N, ILE26J, ILE36N, ILE45N, ILE89J, LEU107J, LEU22J, LEU60N, LEU88J, LEU99J, LYS33J, LYS34J, LYS44N, MET48N, MET66N, PHE25J, PHE93J, PHE94J, PRO102J, PRO106J, PRO28J, PRO96J, SER23J, SER98J, THR37N, THR70N, TRP62N, TRP63N, TRP64N, TYR4N, TYR6N, VAL105J, VAL35N
• K-L: ALA22K, ARG18K, ARG43L, ARG85K, ASN19K, ASP14K, ASP15K, ASP21K, ASP27K, ASP38L, CYS17K, GLN41L, GLN52K, GLN52L, GLU49K, GLU49L, GLY53K, ILE45L, LEU23K, LEU39L, LEU42L, LYS44L, LYS46L, MET48L, SER24K, SER47L, SER55K, THR40L, TRP50K, TRP50L, VAL51K, VAL51L, VAL54K, VAL54L
• K-M: ARG43K, GLN52M, GLU25K, GLU49K, LYS46K, SER47K, TRP50K, TRP50M, VAL51M
• K-N: ALA22K, ALA22N, ALA32K, ARG18N, ARG43K, ARG58N, ASP14N, ASP15N, ASP21K, ASP21N, ASP27K, ASP38K, CYS17N, GLN41K, GLN52N, GLN7N, GLU25K, GLU30K, GLU49K, GLU49N, GLU59N, GLY53N, GLY65N, ILE36K, ILE56N, ILE5N, LEU13N, LEU23K, LEU39K, LEU42K, LEU61N, LEU81K, LEU8N, LYS46K, MET29K, PHE31K, PRO9N, SER10N, SER24K, SER33K, SER55N, THR37K, THR40K, TRP11N, TRP26K, TRP28K, TRP50K, TRP50N, TRP62N, TYR34K, TYR4N, TYR6N, VAL12N, VAL35K, VAL51N, VAL54N
• L-M: ALA22L, ARG18L, ARG43M, ARG85L, ASN19L, ASP14L, ASP21L, ASP27L, CYS17L, GLN41M, GLN52L, GLN52M, GLU25L, GLU49L, GLU49M, GLY53L, ILE45M, LEU23L, LEU39M, LEU42M, LYS44M, LYS46M, MET48M, SER24L, SER47M, THR40M, TRP50L, TRP50M, VAL51L, VAL51M, VAL54L, VAL54M
• L-N: GLN52N, GLU49L, LYS46L, SER47L, TRP50L, VAL51N
• M-N: ALA22M, ARG18M, ARG43N, ARG85M, ASN19M, ASP14M, ASP15M, ASP21M, ASP27M, GLN41N, GLN52M, GLN52N, GLU25M, GLU49M, GLU59N, GLY53M, ILE45N, LEU23M, LEU39N, LEU42N, LYS44N, LYS46N, MET20M, MET48M, MET48N, SER24M, SER47N, SER55M, THR40N, TRP50M, TRP50N, VAL51M, VAL51N, VAL54M, VAL54N